psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N115	R:R:R57	3.62	No	Yes	0	5	5
2	R:R:L116	R:R:R57	8.5	No	Yes	0	5	5
3	R:R:R57	R:R:S373	15.81	Yes	No	0	5	5
4	R:R:F374	R:R:R57	8.55	No	Yes	0	5	5
5	R:R:I58	R:R:L112	5.71	No	No	0	6	6
6	R:R:L377	R:R:L60	5.54	No	No	0	7	6
7	R:R:L112	R:R:Y61	17.58	No	No	0	6	7
8	R:R:S373	R:R:Y61	7.63	No	No	0	5	7
9	R:R:L377	R:R:Y61	3.52	No	No	0	7	7
10	R:R:I64	R:R:M108	5.83	No	No	0	7	7
11	R:R:I64	R:R:L377	4.28	No	No	0	7	7
12	R:R:C384	R:R:I64	3.27	No	No	0	5	7
13	R:R:F65	R:R:V105	3.93	Yes	No	0	7	5
14	R:R:F65	R:R:M108	9.95	Yes	No	0	7	7
15	R:R:C384	R:R:M67	4.86	No	No	0	5	4
16	R:R:N72	R:R:S68	4.47	Yes	No	0	9	8
17	R:R:A104	R:R:S68	3.42	No	No	0	7	8
18	R:R:A383	R:R:S68	3.42	No	No	0	9	8
19	R:R:D100	R:R:N72	12.12	No	Yes	0	9	9
20	R:R:L101	R:R:N72	5.49	No	Yes	0	8	9
21	R:R:N72	R:R:P387	6.52	Yes	No	0	9	9
22	R:R:L101	R:R:M73	4.24	No	No	0	8	4
23	R:R:F392	R:R:L74	6.09	No	No	0	6	7
24	R:R:A97	R:R:I75	3.25	No	Yes	0	9	9
25	R:R:C391	R:R:I75	4.91	No	Yes	0	7	9
26	R:R:F392	R:R:I75	8.79	No	Yes	0	6	9
27	R:R:R396	R:R:V78	3.92	No	No	0	7	8
28	R:R:L79	R:R:N90	8.24	No	No	0	8	9
29	R:R:L81	R:R:R83	4.86	No	No	0	5	7
30	R:R:L85	R:R:S82	7.51	No	No	0	8	6
31	R:R:R83	R:R:R86	4.26	No	No	0	7	8
32	R:R:L85	R:R:R84	7.29	No	No	0	8	5
33	R:R:Q399	R:R:R84	4.67	No	No	0	6	5
34	R:R:R168	R:R:R86	7.46	No	No	0	4	8
35	R:R:N90	R:R:T87	8.77	No	No	0	9	7
36	R:R:A91	R:R:R168	4.15	No	No	0	6	4
37	R:R:F92	R:R:I148	3.77	Yes	No	0	8	9
38	R:R:E151	R:R:F92	8.16	No	Yes	0	9	8
39	R:R:A171	R:R:F92	4.16	No	Yes	0	7	8
40	R:R:F92	R:R:V174	5.24	Yes	No	0	8	6
41	R:R:F92	R:R:I175	3.77	Yes	No	0	8	7
42	R:R:L93	R:R:Y390	5.86	No	Yes	0	8	9
43	R:R:C391	R:R:L93	4.76	No	No	0	7	8
44	R:R:I175	R:R:S95	7.74	No	No	0	7	9
45	R:R:S95	R:R:W179	6.18	No	No	0	9	9
46	R:R:L96	R:R:N386	9.61	No	Yes	0	9	9
47	R:R:S99	R:R:V140	4.85	No	No	0	9	8
48	R:R:A383	R:R:D100	4.63	No	No	0	9	9
49	R:R:D100	R:R:N386	4.04	No	Yes	0	9	9
50	R:R:L102	R:R:L133	5.54	No	No	0	7	5
51	R:R:L102	R:R:S137	6.01	No	No	0	7	7
52	R:R:L103	R:R:S137	7.51	No	No	0	7	7
53	R:R:L103	R:R:Y380	3.52	No	Yes	0	7	7
54	R:R:C107	R:R:M134	8.1	No	No	0	7	8
55	R:R:C107	R:R:Y380	5.38	No	Yes	0	7	7
56	R:R:M108	R:R:Y380	5.99	No	Yes	0	7	7
57	R:R:F110	R:R:F122	5.36	No	Yes	1	6	6
58	R:R:F110	R:R:I126	3.77	No	No	1	6	5
59	R:R:F110	R:R:V130	10.49	No	No	0	6	6
60	R:R:H376	R:R:T111	4.11	No	No	3	5	7
61	R:R:T111	R:R:Y380	8.74	No	Yes	3	7	7
62	R:R:L112	R:R:L116	4.15	No	No	0	6	5
63	R:R:F120	R:R:P114	5.78	Yes	No	1	8	5
64	L:L:?12	R:R:P114	5.89	Yes	No	1	0	5
65	R:R:I372	R:R:N115	4.25	Yes	No	0	4	5
66	R:R:I121	R:R:M117	4.37	No	No	0	4	5
67	L:L:?12	R:R:G118	4.91	Yes	No	0	0	4
68	R:R:F120	R:R:F122	9.65	Yes	Yes	1	8	6
69	R:R:C127	R:R:F120	5.59	No	Yes	1	9	8
70	R:R:C205	R:R:F120	11.17	Yes	Yes	1	9	8
71	L:L:?12	R:R:F120	6.99	Yes	Yes	1	0	8
72	R:R:F122	R:R:I126	6.28	Yes	No	1	6	5
73	R:R:K128	R:R:T124	4.5	No	No	0	7	4
74	R:R:C127	R:R:V195	3.42	No	No	1	9	4
75	R:R:C127	R:R:C205	7.28	No	Yes	1	9	9
76	R:R:K128	R:R:V194	4.55	No	No	0	7	4
77	R:R:M134	R:R:V130	4.56	No	No	0	8	6
78	R:R:S131	R:R:T193	9.59	No	No	0	5	6
79	R:R:V136	R:R:Y132	8.83	No	No	0	6	6
80	R:R:P190	R:R:Y132	9.74	No	No	0	6	6
81	R:R:G135	R:R:M186	6.99	No	No	0	6	8
82	R:R:S182	R:R:V136	3.23	No	No	0	8	6
83	R:R:V138	R:R:W346	8.58	No	Yes	0	7	8
84	L:L:F17	R:R:V138	3.93	No	No	0	0	7
85	R:R:S139	R:R:S182	6.52	No	No	0	8	8
86	R:R:L226	R:R:S139	4.5	No	No	0	8	8
87	R:R:V140	R:R:W179	22.07	No	No	0	8	9
88	R:R:S182	R:R:V140	4.85	No	No	0	8	8
89	R:R:P230	R:R:T142	3.5	No	No	0	9	8
90	R:R:F342	R:R:T142	5.19	No	No	0	9	8
91	R:R:L143	R:R:T178	4.42	No	No	0	6	7
92	R:R:L145	R:R:N386	6.87	No	Yes	0	9	9
93	R:R:L145	R:R:Y390	3.52	No	Yes	0	9	9
94	R:R:P230	R:R:V146	3.53	No	No	0	9	8
95	R:R:I148	R:R:R152	6.26	No	No	2	9	9
96	R:R:I148	R:R:Y390	3.63	No	Yes	2	9	9
97	R:R:A149	R:R:Y238	5.34	No	Yes	0	9	9
98	R:R:E151	R:R:Q166	7.65	No	Yes	0	9	7
99	R:R:E151	R:R:H170	4.92	No	Yes	0	9	7
100	R:R:R152	R:R:Y238	6.17	No	Yes	0	9	9
101	R:R:R152	R:R:Y390	6.17	No	Yes	2	9	9
102	R:R:C157	R:R:Y153	6.72	No	No	0	7	8
103	R:R:R158	R:R:Y153	4.12	Yes	No	0	6	8
104	R:R:L240	R:R:Y153	5.86	No	No	0	6	8
105	R:R:S154	R:R:W165	4.94	No	Yes	0	5	5
106	R:R:A155	R:R:Q166	4.55	No	Yes	0	8	7
107	R:R:C157	R:R:E244	7.6	No	No	0	7	6
108	R:R:A162	R:R:Q166	4.55	No	Yes	0	7	7
109	R:R:Q166	R:R:W165	12.05	Yes	Yes	0	7	5
110	R:R:H170	R:R:W165	8.46	Yes	Yes	0	7	5
111	R:R:S169	R:R:T167	4.8	No	No	0	6	8
112	R:R:H170	R:R:V174	6.92	Yes	No	0	7	6
113	R:R:L185	R:R:W218	3.42	No	Yes	0	6	7
114	R:R:M186	R:R:Y189	3.59	No	Yes	1	8	7
115	R:R:M186	R:R:W218	3.49	No	Yes	1	8	7
116	R:R:P188	R:R:V187	3.53	No	No	0	9	4
117	R:R:P188	R:R:W218	5.4	No	Yes	0	9	7
118	R:R:P190	R:R:Y189	4.17	No	Yes	0	6	7
119	R:R:H207	R:R:Y189	9.8	Yes	Yes	1	5	7
120	R:R:W218	R:R:Y189	10.61	Yes	Yes	1	7	7
121	L:L:D16	R:R:Y189	8.05	Yes	Yes	1	0	7
122	L:L:F17	R:R:Y189	7.22	No	Yes	0	0	7
123	R:R:V191	R:R:Y192	6.31	No	No	0	4	4
124	R:R:P210	R:R:Y192	12.52	No	No	0	4	4
125	R:R:H207	R:R:T193	6.85	Yes	No	0	5	6
126	R:R:Q196	R:R:V194	4.3	No	No	0	3	4
127	R:R:C205	R:R:V195	5.12	Yes	No	1	9	4
128	R:R:Q196	R:R:R208	10.51	No	No	0	3	2
129	R:R:L203	R:R:P197	3.28	No	No	0	3	1
130	R:R:V198	R:R:V202	4.81	No	No	1	1	1
131	R:R:Q204	R:R:V198	5.73	No	No	1	4	1
132	R:R:G199	R:R:P200	4.06	No	No	0	1	3
133	R:R:Q204	R:R:V202	7.16	No	No	1	4	1
134	L:L:?12	R:R:Q204	14.32	Yes	No	1	0	4
135	L:L:?12	R:R:C205	3.41	Yes	Yes	1	0	9
136	L:L:M15	R:R:C205	4.86	No	Yes	1	0	9
137	L:L:M15	R:R:H207	3.94	No	Yes	1	0	5
138	L:L:D16	R:R:H207	8.82	Yes	Yes	1	0	5
139	R:R:P210	R:R:W209	8.11	No	Yes	1	4	6
140	R:R:V214	R:R:W209	7.36	No	Yes	1	4	6
141	R:R:R215	R:R:W209	7	No	Yes	0	5	6
142	R:R:W209	R:R:W218	5.62	Yes	Yes	1	6	7
143	R:R:P210	R:R:V214	8.84	No	No	1	4	4
144	R:R:Q216	R:R:R213	8.18	No	No	0	4	5
145	R:R:F358	R:R:Q216	17.57	No	No	0	5	4
146	R:R:L222	R:R:W218	13.67	No	Yes	0	7	7
147	R:R:S219	R:R:T354	6.4	No	No	0	6	6
148	R:R:A357	R:R:S219	3.42	No	No	0	6	6
149	R:R:F227	R:R:L223	4.87	Yes	No	0	8	7
150	R:R:F227	R:R:F228	4.29	Yes	No	0	8	5
151	R:R:F227	R:R:F343	4.29	Yes	No	0	8	6
152	R:R:F227	R:R:L347	7.31	Yes	No	0	8	7
153	R:R:I229	R:R:P230	3.39	No	No	0	6	9
154	R:R:F342	R:R:M234	7.46	No	No	0	9	8
155	R:R:L335	R:R:Y238	9.38	No	Yes	0	8	9
156	R:R:V339	R:R:Y238	5.05	No	Yes	0	8	9
157	R:R:G239	R:R:S242	3.71	No	No	0	4	6
158	R:R:S242	R:R:V332	3.23	No	No	0	6	7
159	R:R:E244	R:R:R243	6.98	No	No	0	6	5
160	R:R:R330	R:R:R333	11.73	No	No	0	8	6
161	R:R:H394	R:R:M334	5.25	No	No	0	8	8
162	R:R:I338	R:R:V389	4.61	No	No	2	8	8
163	R:R:I338	R:R:Y390	7.25	No	Yes	2	8	9
164	R:R:F342	R:R:W346	6.01	No	Yes	0	9	8
165	R:R:C345	R:R:W346	3.92	No	Yes	4	8	8
166	R:R:C345	R:R:S382	6.89	No	No	4	8	9
167	R:R:W346	R:R:Y350	5.79	Yes	No	0	8	7
168	R:R:S379	R:R:W346	7.41	No	Yes	0	7	8
169	R:R:S382	R:R:W346	8.65	No	Yes	4	9	8
170	R:R:L347	R:R:P348	4.93	No	Yes	0	7	9
171	R:R:I375	R:R:P348	3.39	No	Yes	0	6	9
172	R:R:S379	R:R:V349	6.46	No	No	0	7	7
173	L:L:D16	R:R:N353	12.12	Yes	No	0	0	7
174	R:R:D359	R:R:W355	3.35	No	Yes	0	4	5
175	R:R:A363	R:R:W355	3.89	No	Yes	0	3	5
176	R:R:A366	R:R:W355	3.89	No	Yes	0	4	5
177	R:R:L367	R:R:W355	3.42	No	Yes	0	4	5
178	R:R:H364	R:R:R356	4.51	No	No	1	1	4
179	L:L:W14	R:R:R356	12	Yes	No	1	0	4
180	L:L:D16	R:R:R356	4.76	Yes	No	1	0	4
181	R:R:D359	R:R:G362	3.35	No	No	0	4	4
182	R:R:G360	R:R:P361	4.06	No	No	0	1	1
183	R:R:G362	R:R:R365	4.5	No	No	0	4	3
184	L:L:W14	R:R:A363	3.89	Yes	No	0	0	3
185	L:L:W14	R:R:H364	11.64	Yes	No	1	0	1
186	R:R:L367	R:R:P371	3.28	No	No	0	4	5
187	R:R:G369	R:R:S368	3.71	No	No	0	3	5
188	L:L:A11	R:R:S368	3.42	No	No	0	0	5
189	R:R:A370	R:R:P371	3.74	No	No	0	3	5
190	R:R:I372	R:R:I375	4.42	Yes	No	0	4	6
191	R:R:H376	R:R:I372	5.3	No	Yes	0	5	4
192	L:L:W14	R:R:I372	19.97	Yes	Yes	0	0	4
193	R:R:H376	R:R:Y380	11.98	No	Yes	3	5	7
194	R:R:S379	R:R:Y380	3.82	No	Yes	0	7	7
195	R:R:N386	R:R:P387	3.26	Yes	No	0	9	9
196	R:R:V389	R:R:Y390	3.79	No	Yes	2	8	9
197	R:R:C391	R:R:R396	4.18	No	No	0	7	7
198	R:R:H394	R:R:M393	7.88	No	No	0	8	7
199	R:R:F397	R:R:R395	9.62	No	No	0	8	5
200	R:R:R395	R:R:R398	12.79	No	No	0	5	9
201	R:R:L402	R:R:Q399	5.32	No	No	0	4	6
202	L:L:?12	L:L:G13	6.13	Yes	No	0	0	0
203	L:L:?12	L:L:M15	8.11	Yes	No	1	0	0
204	R:R:V105	R:R:V69	3.21	No	No	0	5	6
205	R:R:V146	R:R:V233	3.21	No	No	0	8	6
206	R:R:A106	R:R:L133	3.15	No	No	0	5	5
207	R:R:I76	R:R:V98	3.07	No	No	0	8	7
208	R:R:F392	R:R:G71	3.01	No	No	0	6	8
209	R:R:F343	R:R:G231	3.01	No	No	0	6	6
210	R:R:L96	R:R:S141	3	No	No	0	9	9
211	R:R:L143	R:R:S139	3	No	No	0	6	8
212	R:R:G360	R:R:R215	3	No	No	0	1	5
213	R:R:L150	R:R:V233	2.98	No	No	0	6	6
214	R:R:L240	R:R:V236	2.98	No	No	0	6	5
215	R:R:L245	R:R:V331	2.98	No	No	0	8	8
216	R:R:L341	R:R:V337	2.98	No	No	0	6	7
217	R:R:L341	R:R:V385	2.98	No	No	0	6	7
218	R:R:L203	R:R:T119	2.95	No	No	0	3	4
219	R:R:L223	R:R:T354	2.95	No	No	0	7	6
220	R:R:I338	R:R:M334	2.92	No	No	0	8	8
221	R:R:G183	R:R:Y132	2.9	No	No	0	5	6
222	R:R:F65	R:R:P109	2.89	Yes	No	0	7	8
223	R:R:I75	R:R:L79	2.85	Yes	No	0	9	8
224	R:R:I76	R:R:L101	2.85	No	No	0	8	8
225	R:R:I241	R:R:L335	2.85	No	No	0	9	8
226	R:R:K324	R:R:L326	2.82	No	No	0	5	5
227	R:R:K328	R:R:L325	2.82	No	No	0	8	4
228	R:R:L79	R:R:L85	2.77	No	No	0	8	8
229	R:R:A147	R:R:F92	2.77	No	Yes	0	7	8
230	R:R:L223	R:R:L224	2.77	No	No	0	7	4
231	R:R:R158	R:R:S154	2.64	Yes	No	0	6	5
232	R:R:F358	R:R:V220	2.62	No	No	0	5	5
233	R:R:F358	R:R:T354	2.59	No	No	0	5	6
234	R:R:F122	R:R:I121	2.51	Yes	No	0	6	4
235	R:R:V164	R:R:W165	2.45	No	Yes	0	4	5
236	R:R:Q161	R:R:R158	2.34	No	Yes	0	5	6
237	L:L:E10	R:R:R365	2.33	No	No	0	0	3
238	R:R:L221	R:R:W218	2.28	No	Yes	0	4	7
239	L:L:?12	L:L:A11	2.26	Yes	No	0	0	0
240	R:R:G70	R:R:G71	2.11	No	No	0	4	8
241	R:R:G118	R:R:T119	1.82	No	No	0	4	4
242	R:R:A171	R:R:A91	1.79	No	No	0	7	6
243	R:R:A149	R:R:A237	1.79	No	No	0	9	6
244	R:R:P348	R:R:S351	1.78	Yes	No	0	9	6
245	R:R:G80	R:R:L94	1.71	No	No	0	3	7
246	R:R:A212	R:R:S211	1.71	No	No	0	3	5
247	R:R:G248	R:R:L247	1.71	No	No	0	6	5
248	R:R:A352	R:R:S351	1.71	No	No	0	5	6
249	R:R:A400	R:R:V78	1.7	No	No	0	8	8
250	R:R:A171	R:R:V88	1.7	No	No	0	7	6
251	R:R:A235	R:R:V339	1.7	No	No	0	5	8
252	R:R:L113	R:R:P109	1.64	No	No	0	5	8
253	R:R:L113	R:R:P114	1.64	No	No	0	5	5
254	R:R:L378	R:R:P348	1.64	No	Yes	0	7	9
255	R:R:S144	R:R:S95	1.63	No	No	0	8	9
256	R:R:A327	R:R:K324	1.61	No	No	0	7	5
257	R:R:V232	R:R:V236	1.6	No	No	0	4	5
258	R:R:V385	R:R:V389	1.6	No	No	0	7	8
259	R:R:T124	R:R:V195	1.59	No	No	0	4	4
260	R:R:T87	R:R:T89	1.57	No	No	0	7	8
261	R:R:K329	R:R:V332	1.52	No	No	0	6	7
262	R:R:L74	R:R:V77	1.49	No	No	0	7	4
263	R:R:L94	R:R:V98	1.49	No	No	0	7	7
264	R:R:P159	R:R:R158	1.44	No	Yes	0	9	6
265	R:R:K328	R:R:K329	1.44	No	No	0	8	6
266	R:R:I58	R:R:L54	1.43	No	No	0	6	5
267	R:R:I156	R:R:L245	1.43	No	No	0	8	8
268	R:R:I241	R:R:L245	1.43	No	No	0	9	8
269	R:R:L185	R:R:L225	1.38	No	No	0	6	5
270	R:R:L221	R:R:L225	1.38	No	No	0	4	5
271	R:R:H170	R:R:T167	1.37	Yes	No	0	7	8
272	R:R:E244	R:R:L247	1.33	No	No	0	6	5
273	R:R:R213	R:R:T217	1.29	No	No	0	5	5
274	R:R:F374	R:R:I56	1.26	No	No	0	5	4
275	R:R:F65	R:R:L66	1.22	Yes	No	0	7	5
276	R:R:K329	R:R:Y246	1.19	No	No	0	6	6
277	R:R:Q399	R:R:R398	1.17	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R57	9.12	4	0	5
2	R:R:F65	4.4975	4	0	7
3	R:R:N72	7.15	4	0	9
4	R:R:I75	4.95	4	0	9
5	R:R:F92	4.645	6	0	8
6	R:R:F120	7.836	5	1	8
7	R:R:F122	5.95	4	1	6
8	R:R:R158	2.635	4	0	6
9	R:R:W165	6.975	4	0	5
10	R:R:Q166	7.2	4	0	7
11	R:R:H170	5.4175	4	0	7
12	R:R:Y189	7.24	6	1	7
13	R:R:C205	6.368	5	1	9
14	R:R:H207	7.3525	4	1	5
15	R:R:W209	7.0225	4	1	6
16	R:R:W218	6.35571	7	1	7
17	R:R:F227	5.19	4	0	8
18	R:R:Y238	6.485	4	0	9
19	R:R:W346	6.72667	6	4	8
20	R:R:P348	2.935	4	0	9
21	R:R:W355	3.6375	4	0	5
22	R:R:I372	8.485	4	0	4
23	R:R:Y380	6.57167	6	3	7
24	R:R:N386	5.945	4	0	9
25	R:R:Y390	5.03667	6	2	9
26	L:L:?12	6.5025	8	1	0
27	L:L:W14	11.875	4	1	0
28	L:L:D16	8.4375	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N115	R:R:R57	10.3378	3.62	No	Yes	0	5	5
2	R:R:M108	R:R:Y380	13.8473	5.99	No	Yes	0	7	7
3	R:R:I372	R:R:N115	11.5198	4.25	Yes	No	0	4	5
4	L:L:W14	R:R:I372	33.6955	19.97	Yes	Yes	0	0	4
5	L:L:W14	R:R:R356	40.2919	12	Yes	No	1	0	4
6	L:L:D16	R:R:R356	41.9057	4.76	Yes	No	1	0	4
7	L:L:D16	R:R:Y189	36.9914	8.05	Yes	Yes	1	0	7
8	R:R:P190	R:R:Y189	99.9727	4.17	No	Yes	0	6	7
9	R:R:P190	R:R:Y132	99.9909	9.74	No	No	0	6	6
10	R:R:V136	R:R:Y132	100	8.83	No	No	0	6	6
11	R:R:S182	R:R:V136	99.9909	3.23	No	No	0	8	6
12	R:R:S182	R:R:V140	99.8091	4.85	No	No	0	8	8
13	R:R:V140	R:R:W179	99.6727	22.07	No	No	0	8	9
14	R:R:S95	R:R:W179	99.5909	6.18	No	No	0	9	9
15	R:R:I175	R:R:S95	99.3999	7.74	No	No	0	7	9
16	R:R:F92	R:R:I175	99.2908	3.77	Yes	No	0	8	7
17	R:R:F92	R:R:I148	72.9781	3.77	Yes	No	0	8	9
18	R:R:I148	R:R:Y390	61.3856	3.63	No	Yes	2	9	9
19	R:R:L145	R:R:Y390	33.3318	3.52	No	Yes	0	9	9
20	R:R:L145	R:R:N386	32.2635	6.87	No	Yes	0	9	9
21	R:R:D100	R:R:N386	16.3159	4.04	No	Yes	0	9	9
22	R:R:D100	R:R:N72	11.3697	12.12	No	Yes	0	9	9
23	R:R:N386	R:R:P387	12.5517	3.26	Yes	No	0	9	9
24	R:R:N72	R:R:P387	11.3425	6.52	Yes	No	0	9	9
25	R:R:L101	R:R:N72	15.243	5.49	No	Yes	0	8	9
26	R:R:C391	R:R:I75	23.8123	4.91	No	Yes	0	7	9
27	R:R:C391	R:R:L93	28.3357	4.76	No	No	0	7	8
28	R:R:L93	R:R:Y390	29.4631	5.86	No	Yes	0	8	9
29	R:R:I75	R:R:L79	15.4521	2.85	Yes	No	0	9	8
30	R:R:L79	R:R:L85	10.3923	2.77	No	No	0	8	8
31	R:R:E151	R:R:F92	40.0327	8.16	No	Yes	0	9	8
32	R:R:F92	R:R:V174	20.4255	5.24	Yes	No	0	8	6
33	L:L:M15	R:R:C205	14.5247	4.86	No	Yes	1	0	9
34	L:L:M15	R:R:H207	39.8873	3.94	No	Yes	1	0	5
35	L:L:?12	L:L:M15	24.5943	8.11	Yes	No	1	0	0
36	R:R:S379	R:R:Y380	20.0027	3.82	No	Yes	0	7	7
37	R:R:S379	R:R:W346	21.1029	7.41	No	Yes	0	7	8
38	R:R:V138	R:R:W346	28.1311	8.58	No	Yes	0	7	8
39	L:L:F17	R:R:Y189	29.7495	7.22	No	Yes	0	0	7
40	R:R:F342	R:R:W346	10.2059	6.01	No	Yes	0	9	8
41	R:R:I148	R:R:R152	10.9379	6.26	No	No	2	9	9
42	R:R:R152	R:R:Y238	12.6472	6.17	No	Yes	0	9	9
43	R:R:E151	R:R:Q166	19.6572	7.65	No	Yes	0	9	7
44	R:R:E151	R:R:H170	19.6027	4.92	No	Yes	0	9	7
45	R:R:H170	R:R:V174	19.4799	6.92	Yes	No	0	7	6
46	R:R:C157	R:R:Y153	16.625	6.72	No	No	0	7	8
47	R:R:R158	R:R:Y153	29.7131	4.12	Yes	No	0	6	8
48	R:R:R158	R:R:S154	39.6963	2.64	Yes	No	0	6	5
49	R:R:S154	R:R:W165	42.8513	4.94	No	Yes	0	5	5
50	R:R:Q166	R:R:W165	16.6523	12.05	Yes	Yes	0	7	5
51	R:R:H170	R:R:W165	32.6408	8.46	Yes	Yes	0	7	5
52	R:R:C157	R:R:E244	13.2427	7.6	No	No	0	7	6
53	R:R:W218	R:R:Y189	20.0164	10.61	Yes	Yes	1	7	7
54	R:R:W209	R:R:W218	10.556	5.62	Yes	Yes	1	6	7
55	R:R:I372	R:R:I375	24.6352	4.42	Yes	No	0	4	6
56	R:R:I375	R:R:P348	23.4896	3.39	No	Yes	0	6	9
57	R:R:L347	R:R:P348	18.8162	4.93	No	Yes	0	7	9
58	R:R:F227	R:R:L347	17.6251	7.31	Yes	No	0	8	7
59	R:R:F227	R:R:L223	12.7699	4.87	Yes	No	0	8	7
60	R:R:L223	R:R:T354	10.2878	2.95	No	No	0	7	6
61	R:R:A363	R:R:W355	11.738	3.89	No	Yes	0	3	5
62	L:L:W14	R:R:A363	12.9654	3.89	Yes	No	0	0	3
63	R:R:I76	R:R:L101	10.1968	2.85	No	No	0	8	8
64	R:R:F120	R:R:F122	11.8016	9.65	Yes	Yes	1	8	6
65	L:L:F17	R:R:V138	28.8221	3.93	No	No	0	0	7
66	R:R:H207	R:R:Y189	36.505	9.8	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F120	R:R:P114	5.78	1	Yes	No	8	5	1	1
L:L:?12	R:R:P114	5.89	1	Yes	No	0	5	0	1
R:R:I372	R:R:N115	4.25	0	Yes	No	4	5	1	2
L:L:?12	R:R:G118	4.91	1	Yes	No	0	4	0	1
R:R:F120	R:R:F122	9.65	1	Yes	Yes	8	6	1	2
R:R:C127	R:R:F120	5.59	1	No	Yes	9	8	2	1
R:R:C205	R:R:F120	11.17	1	Yes	Yes	9	8	1	1
L:L:?12	R:R:F120	6.99	1	Yes	Yes	0	8	0	1
R:R:C127	R:R:V195	3.42	1	No	No	9	4	2	2
R:R:C127	R:R:C205	7.28	1	No	Yes	9	9	2	1
R:R:V138	R:R:W346	8.58	0	No	Yes	7	8	1	2
L:L:F17	R:R:V138	3.93	0	No	No	0	7	0	1
R:R:M186	R:R:Y189	3.59	1	No	Yes	8	7	2	1
R:R:M186	R:R:W218	3.49	1	No	Yes	8	7	2	2
R:R:P190	R:R:Y189	4.17	0	No	Yes	6	7	2	1
R:R:H207	R:R:Y189	9.8	1	Yes	Yes	5	7	1	1
R:R:W218	R:R:Y189	10.61	1	Yes	Yes	7	7	2	1
L:L:D16	R:R:Y189	8.05	1	Yes	Yes	0	7	0	1
L:L:F17	R:R:Y189	7.22	0	No	Yes	0	7	0	1
R:R:H207	R:R:T193	6.85	1	Yes	No	5	6	1	2
R:R:C205	R:R:V195	5.12	1	Yes	No	9	4	1	2
R:R:V198	R:R:V202	4.81	1	No	No	1	1	2	2
R:R:Q204	R:R:V198	5.73	1	No	No	4	1	1	2
R:R:Q204	R:R:V202	7.16	1	No	No	4	1	1	2
L:L:?12	R:R:Q204	14.32	1	Yes	No	0	4	0	1
L:L:?12	R:R:C205	3.41	1	Yes	Yes	0	9	0	1
L:L:M15	R:R:C205	4.86	1	No	Yes	0	9	0	1
L:L:M15	R:R:H207	3.94	1	No	Yes	0	5	0	1
L:L:D16	R:R:H207	8.82	1	Yes	Yes	0	5	0	1
L:L:D16	R:R:N353	12.12	1	Yes	No	0	7	0	1
R:R:A363	R:R:W355	3.89	0	No	Yes	3	5	1	2
R:R:H364	R:R:R356	4.51	1	No	No	1	4	1	1
L:L:W14	R:R:R356	12	1	Yes	No	0	4	0	1
L:L:D16	R:R:R356	4.76	1	Yes	No	0	4	0	1
R:R:G362	R:R:R365	4.5	0	No	No	4	3	2	1
L:L:W14	R:R:A363	3.89	1	Yes	No	0	3	0	1
L:L:W14	R:R:H364	11.64	1	Yes	No	0	1	0	1
R:R:G369	R:R:S368	3.71	0	No	No	3	5	2	1
L:L:A11	R:R:S368	3.42	0	No	No	0	5	0	1
R:R:I372	R:R:I375	4.42	0	Yes	No	4	6	1	2
R:R:H376	R:R:I372	5.3	3	No	Yes	5	4	2	1
L:L:W14	R:R:I372	19.97	1	Yes	Yes	0	4	0	1
L:L:E10	R:R:R365	2.33	0	No	No	0	3	0	1
R:R:G118	R:R:T119	1.82	0	No	No	4	4	1	2
R:R:L113	R:R:P114	1.64	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XOW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	258
Number of Links	277
Number of Hubs	28
Number of Links mediated by Hubs	119
Number of Communities	4
Number of Nodes involved in Communities	35
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	41718
Length Of Smallest Path	3
Average Path Length	16.082
Length of Longest Path	36
Minimum Path Strength	1.315
Average Path Strength	6.34448
Maximum Path Strength	15.805
Minimum Path Correlation	0.7
Average Path Correlation	0.918092
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	38.3656
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.5378
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • molecular function regulator activity • 1-phosphatidylinositol-3-kinase regulator activity • kinase regulator activity • protein binding • binding • signaling receptor binding • type B gastrin/cholecystokinin receptor binding • G protein-coupled receptor binding • cholecystokinin receptor binding • neuropeptide receptor binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • gastrin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • cholecystokinin receptor activity • localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus
Gene Ontology	Biological Process	• localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cholecystokinin signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • developmental process • gland development • animal organ development • anatomical structure development • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organism development • digestive system development • tube development • digestive tract development • system development • chemical homeostasis • homeostatic process • regulation of pH • monoatomic ion homeostasis • monoatomic cation homeostasis • pH reduction • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • response to nutrient levels • response to food • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • nucleoside-triphosphatase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • regulation of signaling • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • hormone-mediated signaling pathway • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • sensory perception of itch • establishment of organelle localization • regulated exocytosis • cellular localization • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • cell activation • vacuolar localization • export from cell • mast cell degranulation • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • postsynapse • postsynaptic cytosol • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • ciliary basal body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32239
Sequence	>7XOW_nogp_Chain_R E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S R R L R T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G T F I F G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R P L Q A R V W Q T R S H A A R V I V A T W L L S G L L M V P Y P V Y T V V Q P V G P R V L Q C V H R W P S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G P G A H R A L S G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R F R Q A C L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Sulfated Gastrin-(10-17)
UniProt	P01350
Sequence	>7XOW_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F8V	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	Gi2/β1/γ2	3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8V (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	chim(NtGsL-Gq)/β1/γ2	3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7XOW	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Sulfated Gastrin-(10-17)	-	chim(NtGi1-Gq)/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOW (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Sulfated Gastrin-(10-17)	-		3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	8IA7	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gq)/β1/γ2	3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	8IA7 (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-		3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.