psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N115	R:R:R57	3.62	No	Yes	0	5	5
2	R:R:L116	R:R:R57	8.5	No	Yes	0	5	5
3	R:R:R57	R:R:S373	15.81	Yes	No	0	5	5
4	R:R:F374	R:R:R57	8.55	No	Yes	0	5	5
5	R:R:I58	R:R:L112	5.71	No	No	0	6	6
6	R:R:L377	R:R:L60	5.54	No	No	0	7	6
7	R:R:L112	R:R:Y61	17.58	No	No	0	6	7
8	R:R:S373	R:R:Y61	7.63	No	No	0	5	7
9	R:R:L377	R:R:Y61	3.52	No	No	0	7	7
10	R:R:I64	R:R:M108	5.83	No	No	0	7	7
11	R:R:I64	R:R:L377	4.28	No	No	0	7	7
12	R:R:C384	R:R:I64	3.27	No	No	0	5	7
13	R:R:F65	R:R:V105	3.93	Yes	No	0	7	5
14	R:R:F65	R:R:M108	9.95	Yes	No	0	7	7
15	R:R:C384	R:R:M67	4.86	No	No	0	5	4
16	R:R:N72	R:R:S68	4.47	Yes	No	0	9	8
17	R:R:A104	R:R:S68	3.42	No	No	0	7	8
18	R:R:A383	R:R:S68	3.42	No	No	0	9	8
19	R:R:D100	R:R:N72	12.12	No	Yes	0	9	9
20	R:R:L101	R:R:N72	5.49	No	Yes	0	8	9
21	R:R:N72	R:R:P387	6.52	Yes	No	0	9	9
22	R:R:L101	R:R:M73	4.24	No	No	0	8	4
23	R:R:F392	R:R:L74	6.09	No	No	0	6	7
24	R:R:A97	R:R:I75	3.25	No	Yes	0	9	9
25	R:R:C391	R:R:I75	4.91	No	Yes	0	7	9
26	R:R:F392	R:R:I75	8.79	No	Yes	0	6	9
27	R:R:R396	R:R:V78	3.92	No	No	0	7	8
28	R:R:L79	R:R:N90	8.24	No	No	0	8	9
29	R:R:L81	R:R:R83	4.86	No	No	0	5	7
30	R:R:L85	R:R:S82	7.51	No	No	0	8	6
31	R:R:R83	R:R:R86	4.26	No	No	0	7	8
32	R:R:L85	R:R:R84	7.29	No	No	0	8	5
33	R:R:Q399	R:R:R84	4.67	No	No	0	6	5
34	R:R:R168	R:R:R86	7.46	No	No	0	4	8
35	R:R:N90	R:R:T87	8.77	No	No	0	9	7
36	R:R:A91	R:R:R168	4.15	No	No	0	6	4
37	R:R:F92	R:R:I148	3.77	Yes	No	0	8	9
38	R:R:E151	R:R:F92	8.16	No	Yes	0	9	8
39	R:R:A171	R:R:F92	4.16	No	Yes	0	7	8
40	R:R:F92	R:R:V174	5.24	Yes	No	0	8	6
41	R:R:F92	R:R:I175	3.77	Yes	No	0	8	7
42	R:R:L93	R:R:Y390	5.86	No	Yes	0	8	9
43	R:R:C391	R:R:L93	4.76	No	No	0	7	8
44	R:R:I175	R:R:S95	7.74	No	No	0	7	9
45	R:R:S95	R:R:W179	6.18	No	No	0	9	9
46	R:R:L96	R:R:N386	9.61	No	Yes	0	9	9
47	R:R:S99	R:R:V140	4.85	No	No	0	9	8
48	R:R:A383	R:R:D100	4.63	No	No	0	9	9
49	R:R:D100	R:R:N386	4.04	No	Yes	0	9	9
50	R:R:L102	R:R:L133	5.54	No	No	0	7	5
51	R:R:L102	R:R:S137	6.01	No	No	0	7	7
52	R:R:L103	R:R:S137	7.51	No	No	0	7	7
53	R:R:L103	R:R:Y380	3.52	No	Yes	0	7	7
54	R:R:C107	R:R:M134	8.1	No	No	0	7	8
55	R:R:C107	R:R:Y380	5.38	No	Yes	0	7	7
56	R:R:M108	R:R:Y380	5.99	No	Yes	0	7	7
57	R:R:F110	R:R:F122	5.36	No	Yes	1	6	6
58	R:R:F110	R:R:I126	3.77	No	No	1	6	5
59	R:R:F110	R:R:V130	10.49	No	No	0	6	6
60	R:R:H376	R:R:T111	4.11	No	No	3	5	7
61	R:R:T111	R:R:Y380	8.74	No	Yes	3	7	7
62	R:R:L112	R:R:L116	4.15	No	No	0	6	5
63	R:R:F120	R:R:P114	5.78	Yes	No	1	8	5
64	L:L:?12	R:R:P114	5.89	Yes	No	1	0	5
65	R:R:I372	R:R:N115	4.25	Yes	No	0	4	5
66	R:R:I121	R:R:M117	4.37	No	No	0	4	5
67	L:L:?12	R:R:G118	4.91	Yes	No	0	0	4
68	R:R:F120	R:R:F122	9.65	Yes	Yes	1	8	6
69	R:R:C127	R:R:F120	5.59	No	Yes	1	9	8
70	R:R:C205	R:R:F120	11.17	Yes	Yes	1	9	8
71	L:L:?12	R:R:F120	6.99	Yes	Yes	1	0	8
72	R:R:F122	R:R:I126	6.28	Yes	No	1	6	5
73	R:R:K128	R:R:T124	4.5	No	No	0	7	4
74	R:R:C127	R:R:V195	3.42	No	No	1	9	4
75	R:R:C127	R:R:C205	7.28	No	Yes	1	9	9
76	R:R:K128	R:R:V194	4.55	No	No	0	7	4
77	R:R:M134	R:R:V130	4.56	No	No	0	8	6
78	R:R:S131	R:R:T193	9.59	No	No	0	5	6
79	R:R:V136	R:R:Y132	8.83	No	No	0	6	6
80	R:R:P190	R:R:Y132	9.74	No	No	0	6	6
81	R:R:G135	R:R:M186	6.99	No	No	0	6	8
82	R:R:S182	R:R:V136	3.23	No	No	0	8	6
83	R:R:V138	R:R:W346	8.58	No	Yes	0	7	8
84	L:L:F17	R:R:V138	3.93	No	No	0	0	7
85	R:R:S139	R:R:S182	6.52	No	No	0	8	8
86	R:R:L226	R:R:S139	4.5	No	No	0	8	8
87	R:R:V140	R:R:W179	22.07	No	No	0	8	9
88	R:R:S182	R:R:V140	4.85	No	No	0	8	8
89	R:R:P230	R:R:T142	3.5	No	No	0	9	8
90	R:R:F342	R:R:T142	5.19	No	No	0	9	8
91	R:R:L143	R:R:T178	4.42	No	No	0	6	7
92	R:R:L145	R:R:N386	6.87	No	Yes	0	9	9
93	R:R:L145	R:R:Y390	3.52	No	Yes	0	9	9
94	R:R:P230	R:R:V146	3.53	No	No	0	9	8
95	R:R:I148	R:R:R152	6.26	No	No	2	9	9
96	R:R:I148	R:R:Y390	3.63	No	Yes	2	9	9
97	R:R:A149	R:R:Y238	5.34	No	Yes	0	9	9
98	R:R:E151	R:R:Q166	7.65	No	Yes	0	9	7
99	R:R:E151	R:R:H170	4.92	No	Yes	0	9	7
100	R:R:R152	R:R:Y238	6.17	No	Yes	0	9	9
101	R:R:R152	R:R:Y390	6.17	No	Yes	2	9	9
102	R:R:C157	R:R:Y153	6.72	No	No	0	7	8
103	R:R:R158	R:R:Y153	4.12	Yes	No	0	6	8
104	R:R:L240	R:R:Y153	5.86	No	No	0	6	8
105	R:R:S154	R:R:W165	4.94	No	Yes	0	5	5
106	R:R:A155	R:R:Q166	4.55	No	Yes	0	8	7
107	R:R:C157	R:R:E244	7.6	No	No	0	7	6
108	R:R:A162	R:R:Q166	4.55	No	Yes	0	7	7
109	R:R:Q166	R:R:W165	12.05	Yes	Yes	0	7	5
110	R:R:H170	R:R:W165	8.46	Yes	Yes	0	7	5
111	R:R:S169	R:R:T167	4.8	No	No	0	6	8
112	R:R:H170	R:R:V174	6.92	Yes	No	0	7	6
113	R:R:L185	R:R:W218	3.42	No	Yes	0	6	7
114	R:R:M186	R:R:Y189	3.59	No	Yes	1	8	7
115	R:R:M186	R:R:W218	3.49	No	Yes	1	8	7
116	R:R:P188	R:R:V187	3.53	No	No	0	9	4
117	R:R:P188	R:R:W218	5.4	No	Yes	0	9	7
118	R:R:P190	R:R:Y189	4.17	No	Yes	0	6	7
119	R:R:H207	R:R:Y189	9.8	Yes	Yes	1	5	7
120	R:R:W218	R:R:Y189	10.61	Yes	Yes	1	7	7
121	L:L:D16	R:R:Y189	8.05	Yes	Yes	1	0	7
122	L:L:F17	R:R:Y189	7.22	No	Yes	0	0	7
123	R:R:V191	R:R:Y192	6.31	No	No	0	4	4
124	R:R:P210	R:R:Y192	12.52	No	No	0	4	4
125	R:R:H207	R:R:T193	6.85	Yes	No	0	5	6
126	R:R:Q196	R:R:V194	4.3	No	No	0	3	4
127	R:R:C205	R:R:V195	5.12	Yes	No	1	9	4
128	R:R:Q196	R:R:R208	10.51	No	No	0	3	2
129	R:R:L203	R:R:P197	3.28	No	No	0	3	1
130	R:R:V198	R:R:V202	4.81	No	No	1	1	1
131	R:R:Q204	R:R:V198	5.73	No	No	1	4	1
132	R:R:G199	R:R:P200	4.06	No	No	0	1	3
133	R:R:Q204	R:R:V202	7.16	No	No	1	4	1
134	L:L:?12	R:R:Q204	14.32	Yes	No	1	0	4
135	L:L:?12	R:R:C205	3.41	Yes	Yes	1	0	9
136	L:L:M15	R:R:C205	4.86	No	Yes	1	0	9
137	L:L:M15	R:R:H207	3.94	No	Yes	1	0	5
138	L:L:D16	R:R:H207	8.82	Yes	Yes	1	0	5
139	R:R:P210	R:R:W209	8.11	No	Yes	1	4	6
140	R:R:V214	R:R:W209	7.36	No	Yes	1	4	6
141	R:R:R215	R:R:W209	7	No	Yes	0	5	6
142	R:R:W209	R:R:W218	5.62	Yes	Yes	1	6	7
143	R:R:P210	R:R:V214	8.84	No	No	1	4	4
144	R:R:Q216	R:R:R213	8.18	No	No	0	4	5
145	R:R:F358	R:R:Q216	17.57	No	No	0	5	4
146	R:R:L222	R:R:W218	13.67	No	Yes	0	7	7
147	R:R:S219	R:R:T354	6.4	No	No	0	6	6
148	R:R:A357	R:R:S219	3.42	No	No	0	6	6
149	R:R:F227	R:R:L223	4.87	Yes	No	0	8	7
150	R:R:F227	R:R:F228	4.29	Yes	No	0	8	5
151	R:R:F227	R:R:F343	4.29	Yes	No	0	8	6
152	R:R:F227	R:R:L347	7.31	Yes	No	0	8	7
153	R:R:I229	R:R:P230	3.39	No	No	0	6	9
154	R:R:F342	R:R:M234	7.46	No	No	0	9	8
155	R:R:L335	R:R:Y238	9.38	No	Yes	0	8	9
156	R:R:V339	R:R:Y238	5.05	No	Yes	0	8	9
157	R:R:G239	R:R:S242	3.71	No	No	0	4	6
158	R:R:S242	R:R:V332	3.23	No	No	0	6	7
159	R:R:E244	R:R:R243	6.98	No	No	0	6	5
160	R:R:R330	R:R:R333	11.73	No	No	0	8	6
161	R:R:H394	R:R:M334	5.25	No	No	0	8	8
162	R:R:I338	R:R:V389	4.61	No	No	2	8	8
163	R:R:I338	R:R:Y390	7.25	No	Yes	2	8	9
164	R:R:F342	R:R:W346	6.01	No	Yes	0	9	8
165	R:R:C345	R:R:W346	3.92	No	Yes	4	8	8
166	R:R:C345	R:R:S382	6.89	No	No	4	8	9
167	R:R:W346	R:R:Y350	5.79	Yes	No	0	8	7
168	R:R:S379	R:R:W346	7.41	No	Yes	0	7	8
169	R:R:S382	R:R:W346	8.65	No	Yes	4	9	8
170	R:R:L347	R:R:P348	4.93	No	Yes	0	7	9
171	R:R:I375	R:R:P348	3.39	No	Yes	0	6	9
172	R:R:S379	R:R:V349	6.46	No	No	0	7	7
173	L:L:D16	R:R:N353	12.12	Yes	No	0	0	7
174	R:R:D359	R:R:W355	3.35	No	Yes	0	4	5
175	R:R:A363	R:R:W355	3.89	No	Yes	0	3	5
176	R:R:A366	R:R:W355	3.89	No	Yes	0	4	5
177	R:R:L367	R:R:W355	3.42	No	Yes	0	4	5
178	R:R:H364	R:R:R356	4.51	No	No	1	1	4
179	L:L:W14	R:R:R356	12	Yes	No	1	0	4
180	L:L:D16	R:R:R356	4.76	Yes	No	1	0	4
181	R:R:D359	R:R:G362	3.35	No	No	0	4	4
182	R:R:G360	R:R:P361	4.06	No	No	0	1	1
183	R:R:G362	R:R:R365	4.5	No	No	0	4	3
184	L:L:W14	R:R:A363	3.89	Yes	No	0	0	3
185	L:L:W14	R:R:H364	11.64	Yes	No	1	0	1
186	R:R:L367	R:R:P371	3.28	No	No	0	4	5
187	R:R:G369	R:R:S368	3.71	No	No	0	3	5
188	L:L:A11	R:R:S368	3.42	No	No	0	0	5
189	R:R:A370	R:R:P371	3.74	No	No	0	3	5
190	R:R:I372	R:R:I375	4.42	Yes	No	0	4	6
191	R:R:H376	R:R:I372	5.3	No	Yes	0	5	4
192	L:L:W14	R:R:I372	19.97	Yes	Yes	0	0	4
193	R:R:H376	R:R:Y380	11.98	No	Yes	3	5	7
194	R:R:S379	R:R:Y380	3.82	No	Yes	0	7	7
195	R:R:N386	R:R:P387	3.26	Yes	No	0	9	9
196	R:R:V389	R:R:Y390	3.79	No	Yes	2	8	9
197	R:R:C391	R:R:R396	4.18	No	No	0	7	7
198	R:R:H394	R:R:M393	7.88	No	No	0	8	7
199	R:R:F397	R:R:R395	9.62	No	No	0	8	5
200	R:R:R395	R:R:R398	12.79	No	No	0	5	9
201	R:R:L402	R:R:Q399	5.32	No	No	0	4	6
202	L:L:?12	L:L:G13	6.13	Yes	No	0	0	0
203	L:L:?12	L:L:M15	8.11	Yes	No	1	0	0
204	R:R:V105	R:R:V69	3.21	No	No	0	5	6
205	R:R:V146	R:R:V233	3.21	No	No	0	8	6
206	R:R:A106	R:R:L133	3.15	No	No	0	5	5
207	R:R:I76	R:R:V98	3.07	No	No	0	8	7
208	R:R:F392	R:R:G71	3.01	No	No	0	6	8
209	R:R:F343	R:R:G231	3.01	No	No	0	6	6
210	R:R:L96	R:R:S141	3	No	No	0	9	9
211	R:R:L143	R:R:S139	3	No	No	0	6	8
212	R:R:G360	R:R:R215	3	No	No	0	1	5
213	R:R:L150	R:R:V233	2.98	No	No	0	6	6
214	R:R:L240	R:R:V236	2.98	No	No	0	6	5
215	R:R:L245	R:R:V331	2.98	No	No	0	8	8
216	R:R:L341	R:R:V337	2.98	No	No	0	6	7
217	R:R:L341	R:R:V385	2.98	No	No	0	6	7
218	R:R:L203	R:R:T119	2.95	No	No	0	3	4
219	R:R:L223	R:R:T354	2.95	No	No	0	7	6
220	R:R:I338	R:R:M334	2.92	No	No	0	8	8
221	R:R:G183	R:R:Y132	2.9	No	No	0	5	6
222	R:R:F65	R:R:P109	2.89	Yes	No	0	7	8
223	R:R:I75	R:R:L79	2.85	Yes	No	0	9	8
224	R:R:I76	R:R:L101	2.85	No	No	0	8	8
225	R:R:I241	R:R:L335	2.85	No	No	0	9	8
226	R:R:K324	R:R:L326	2.82	No	No	0	5	5
227	R:R:K328	R:R:L325	2.82	No	No	0	8	4
228	R:R:L79	R:R:L85	2.77	No	No	0	8	8
229	R:R:A147	R:R:F92	2.77	No	Yes	0	7	8
230	R:R:L223	R:R:L224	2.77	No	No	0	7	4
231	R:R:R158	R:R:S154	2.64	Yes	No	0	6	5
232	R:R:F358	R:R:V220	2.62	No	No	0	5	5
233	R:R:F358	R:R:T354	2.59	No	No	0	5	6
234	R:R:F122	R:R:I121	2.51	Yes	No	0	6	4
235	R:R:V164	R:R:W165	2.45	No	Yes	0	4	5
236	R:R:Q161	R:R:R158	2.34	No	Yes	0	5	6
237	L:L:E10	R:R:R365	2.33	No	No	0	0	3
238	R:R:L221	R:R:W218	2.28	No	Yes	0	4	7
239	L:L:?12	L:L:A11	2.26	Yes	No	0	0	0
240	R:R:G70	R:R:G71	2.11	No	No	0	4	8
241	R:R:G118	R:R:T119	1.82	No	No	0	4	4
242	R:R:A171	R:R:A91	1.79	No	No	0	7	6
243	R:R:A149	R:R:A237	1.79	No	No	0	9	6
244	R:R:P348	R:R:S351	1.78	Yes	No	0	9	6
245	R:R:G80	R:R:L94	1.71	No	No	0	3	7
246	R:R:A212	R:R:S211	1.71	No	No	0	3	5
247	R:R:G248	R:R:L247	1.71	No	No	0	6	5
248	R:R:A352	R:R:S351	1.71	No	No	0	5	6
249	R:R:A400	R:R:V78	1.7	No	No	0	8	8
250	R:R:A171	R:R:V88	1.7	No	No	0	7	6
251	R:R:A235	R:R:V339	1.7	No	No	0	5	8
252	R:R:L113	R:R:P109	1.64	No	No	0	5	8
253	R:R:L113	R:R:P114	1.64	No	No	0	5	5
254	R:R:L378	R:R:P348	1.64	No	Yes	0	7	9
255	R:R:S144	R:R:S95	1.63	No	No	0	8	9
256	R:R:A327	R:R:K324	1.61	No	No	0	7	5
257	R:R:V232	R:R:V236	1.6	No	No	0	4	5
258	R:R:V385	R:R:V389	1.6	No	No	0	7	8
259	R:R:T124	R:R:V195	1.59	No	No	0	4	4
260	R:R:T87	R:R:T89	1.57	No	No	0	7	8
261	R:R:K329	R:R:V332	1.52	No	No	0	6	7
262	R:R:L74	R:R:V77	1.49	No	No	0	7	4
263	R:R:L94	R:R:V98	1.49	No	No	0	7	7
264	R:R:P159	R:R:R158	1.44	No	Yes	0	9	6
265	R:R:K328	R:R:K329	1.44	No	No	0	8	6
266	R:R:I58	R:R:L54	1.43	No	No	0	6	5
267	R:R:I156	R:R:L245	1.43	No	No	0	8	8
268	R:R:I241	R:R:L245	1.43	No	No	0	9	8
269	R:R:L185	R:R:L225	1.38	No	No	0	6	5
270	R:R:L221	R:R:L225	1.38	No	No	0	4	5
271	R:R:H170	R:R:T167	1.37	Yes	No	0	7	8
272	R:R:E244	R:R:L247	1.33	No	No	0	6	5
273	R:R:R213	R:R:T217	1.29	No	No	0	5	5
274	R:R:F374	R:R:I56	1.26	No	No	0	5	4
275	R:R:F65	R:R:L66	1.22	Yes	No	0	7	5
276	R:R:K329	R:R:Y246	1.19	No	No	0	6	6
277	R:R:Q399	R:R:R398	1.17	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R57	9.12	4	0	5
2	R:R:F65	4.4975	4	0	7
3	R:R:N72	7.15	4	0	9
4	R:R:I75	4.95	4	0	9
5	R:R:F92	4.645	6	0	8
6	R:R:F120	7.836	5	1	8
7	R:R:F122	5.95	4	1	6
8	R:R:R158	2.635	4	0	6
9	R:R:W165	6.975	4	0	5
10	R:R:Q166	7.2	4	0	7
11	R:R:H170	5.4175	4	0	7
12	R:R:Y189	7.24	6	1	7
13	R:R:C205	6.368	5	1	9
14	R:R:H207	7.3525	4	1	5
15	R:R:W209	7.0225	4	1	6
16	R:R:W218	6.35571	7	1	7
17	R:R:F227	5.19	4	0	8
18	R:R:Y238	6.485	4	0	9
19	R:R:W346	6.72667	6	4	8
20	R:R:P348	2.935	4	0	9
21	R:R:W355	3.6375	4	0	5
22	R:R:I372	8.485	4	0	4
23	R:R:Y380	6.57167	6	3	7
24	R:R:N386	5.945	4	0	9
25	R:R:Y390	5.03667	6	2	9
26	L:L:?12	6.5025	8	1	0
27	L:L:W14	11.875	4	1	0
28	L:L:D16	8.4375	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N115	R:R:R57	10.3378	3.62	No	Yes	0	5	5
2	R:R:M108	R:R:Y380	13.8473	5.99	No	Yes	0	7	7
3	R:R:I372	R:R:N115	11.5198	4.25	Yes	No	0	4	5
4	L:L:W14	R:R:I372	33.6955	19.97	Yes	Yes	0	0	4
5	L:L:W14	R:R:R356	40.2919	12	Yes	No	1	0	4
6	L:L:D16	R:R:R356	41.9057	4.76	Yes	No	1	0	4
7	L:L:D16	R:R:Y189	36.9914	8.05	Yes	Yes	1	0	7
8	R:R:P190	R:R:Y189	99.9727	4.17	No	Yes	0	6	7
9	R:R:P190	R:R:Y132	99.9909	9.74	No	No	0	6	6
10	R:R:V136	R:R:Y132	100	8.83	No	No	0	6	6
11	R:R:S182	R:R:V136	99.9909	3.23	No	No	0	8	6
12	R:R:S182	R:R:V140	99.8091	4.85	No	No	0	8	8
13	R:R:V140	R:R:W179	99.6727	22.07	No	No	0	8	9
14	R:R:S95	R:R:W179	99.5909	6.18	No	No	0	9	9
15	R:R:I175	R:R:S95	99.3999	7.74	No	No	0	7	9
16	R:R:F92	R:R:I175	99.2908	3.77	Yes	No	0	8	7
17	R:R:F92	R:R:I148	72.9781	3.77	Yes	No	0	8	9
18	R:R:I148	R:R:Y390	61.3856	3.63	No	Yes	2	9	9
19	R:R:L145	R:R:Y390	33.3318	3.52	No	Yes	0	9	9
20	R:R:L145	R:R:N386	32.2635	6.87	No	Yes	0	9	9
21	R:R:D100	R:R:N386	16.3159	4.04	No	Yes	0	9	9
22	R:R:D100	R:R:N72	11.3697	12.12	No	Yes	0	9	9
23	R:R:N386	R:R:P387	12.5517	3.26	Yes	No	0	9	9
24	R:R:N72	R:R:P387	11.3425	6.52	Yes	No	0	9	9
25	R:R:L101	R:R:N72	15.243	5.49	No	Yes	0	8	9
26	R:R:C391	R:R:I75	23.8123	4.91	No	Yes	0	7	9
27	R:R:C391	R:R:L93	28.3357	4.76	No	No	0	7	8
28	R:R:L93	R:R:Y390	29.4631	5.86	No	Yes	0	8	9
29	R:R:I75	R:R:L79	15.4521	2.85	Yes	No	0	9	8
30	R:R:L79	R:R:L85	10.3923	2.77	No	No	0	8	8
31	R:R:E151	R:R:F92	40.0327	8.16	No	Yes	0	9	8
32	R:R:F92	R:R:V174	20.4255	5.24	Yes	No	0	8	6
33	L:L:M15	R:R:C205	14.5247	4.86	No	Yes	1	0	9
34	L:L:M15	R:R:H207	39.8873	3.94	No	Yes	1	0	5
35	L:L:?12	L:L:M15	24.5943	8.11	Yes	No	1	0	0
36	R:R:S379	R:R:Y380	20.0027	3.82	No	Yes	0	7	7
37	R:R:S379	R:R:W346	21.1029	7.41	No	Yes	0	7	8
38	R:R:V138	R:R:W346	28.1311	8.58	No	Yes	0	7	8
39	L:L:F17	R:R:Y189	29.7495	7.22	No	Yes	0	0	7
40	R:R:F342	R:R:W346	10.2059	6.01	No	Yes	0	9	8
41	R:R:I148	R:R:R152	10.9379	6.26	No	No	2	9	9
42	R:R:R152	R:R:Y238	12.6472	6.17	No	Yes	0	9	9
43	R:R:E151	R:R:Q166	19.6572	7.65	No	Yes	0	9	7
44	R:R:E151	R:R:H170	19.6027	4.92	No	Yes	0	9	7
45	R:R:H170	R:R:V174	19.4799	6.92	Yes	No	0	7	6
46	R:R:C157	R:R:Y153	16.625	6.72	No	No	0	7	8
47	R:R:R158	R:R:Y153	29.7131	4.12	Yes	No	0	6	8
48	R:R:R158	R:R:S154	39.6963	2.64	Yes	No	0	6	5
49	R:R:S154	R:R:W165	42.8513	4.94	No	Yes	0	5	5
50	R:R:Q166	R:R:W165	16.6523	12.05	Yes	Yes	0	7	5
51	R:R:H170	R:R:W165	32.6408	8.46	Yes	Yes	0	7	5
52	R:R:C157	R:R:E244	13.2427	7.6	No	No	0	7	6
53	R:R:W218	R:R:Y189	20.0164	10.61	Yes	Yes	1	7	7
54	R:R:W209	R:R:W218	10.556	5.62	Yes	Yes	1	6	7
55	R:R:I372	R:R:I375	24.6352	4.42	Yes	No	0	4	6
56	R:R:I375	R:R:P348	23.4896	3.39	No	Yes	0	6	9
57	R:R:L347	R:R:P348	18.8162	4.93	No	Yes	0	7	9
58	R:R:F227	R:R:L347	17.6251	7.31	Yes	No	0	8	7
59	R:R:F227	R:R:L223	12.7699	4.87	Yes	No	0	8	7
60	R:R:L223	R:R:T354	10.2878	2.95	No	No	0	7	6
61	R:R:A363	R:R:W355	11.738	3.89	No	Yes	0	3	5
62	L:L:W14	R:R:A363	12.9654	3.89	Yes	No	0	0	3
63	R:R:I76	R:R:L101	10.1968	2.85	No	No	0	8	8
64	R:R:F120	R:R:F122	11.8016	9.65	Yes	Yes	1	8	6
65	L:L:F17	R:R:V138	28.8221	3.93	No	No	0	0	7
66	R:R:H207	R:R:Y189	36.505	9.8	Yes	Yes	1	5	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F120	R:R:P114	5.78	1	Yes	No	8	5	1	1
L:L:?12	R:R:P114	5.89	1	Yes	No	0	5	0	1
R:R:I372	R:R:N115	4.25	0	Yes	No	4	5	1	2
L:L:?12	R:R:G118	4.91	1	Yes	No	0	4	0	1
R:R:F120	R:R:F122	9.65	1	Yes	Yes	8	6	1	2
R:R:C127	R:R:F120	5.59	1	No	Yes	9	8	2	1
R:R:C205	R:R:F120	11.17	1	Yes	Yes	9	8	1	1
L:L:?12	R:R:F120	6.99	1	Yes	Yes	0	8	0	1
R:R:C127	R:R:V195	3.42	1	No	No	9	4	2	2
R:R:C127	R:R:C205	7.28	1	No	Yes	9	9	2	1
R:R:V138	R:R:W346	8.58	0	No	Yes	7	8	1	2
L:L:F17	R:R:V138	3.93	0	No	No	0	7	0	1
R:R:M186	R:R:Y189	3.59	1	No	Yes	8	7	2	1
R:R:M186	R:R:W218	3.49	1	No	Yes	8	7	2	2
R:R:P190	R:R:Y189	4.17	0	No	Yes	6	7	2	1
R:R:H207	R:R:Y189	9.8	1	Yes	Yes	5	7	1	1
R:R:W218	R:R:Y189	10.61	1	Yes	Yes	7	7	2	1
L:L:D16	R:R:Y189	8.05	1	Yes	Yes	0	7	0	1
L:L:F17	R:R:Y189	7.22	0	No	Yes	0	7	0	1
R:R:H207	R:R:T193	6.85	1	Yes	No	5	6	1	2
R:R:C205	R:R:V195	5.12	1	Yes	No	9	4	1	2
R:R:V198	R:R:V202	4.81	1	No	No	1	1	2	2
R:R:Q204	R:R:V198	5.73	1	No	No	4	1	1	2
R:R:Q204	R:R:V202	7.16	1	No	No	4	1	1	2
L:L:?12	R:R:Q204	14.32	1	Yes	No	0	4	0	1
L:L:?12	R:R:C205	3.41	1	Yes	Yes	0	9	0	1
L:L:M15	R:R:C205	4.86	1	No	Yes	0	9	0	1
L:L:M15	R:R:H207	3.94	1	No	Yes	0	5	0	1
L:L:D16	R:R:H207	8.82	1	Yes	Yes	0	5	0	1
L:L:D16	R:R:N353	12.12	1	Yes	No	0	7	0	1
R:R:A363	R:R:W355	3.89	0	No	Yes	3	5	1	2
R:R:H364	R:R:R356	4.51	1	No	No	1	4	1	1
L:L:W14	R:R:R356	12	1	Yes	No	0	4	0	1
L:L:D16	R:R:R356	4.76	1	Yes	No	0	4	0	1
R:R:G362	R:R:R365	4.5	0	No	No	4	3	2	1
L:L:W14	R:R:A363	3.89	1	Yes	No	0	3	0	1
L:L:W14	R:R:H364	11.64	1	Yes	No	0	1	0	1
R:R:G369	R:R:S368	3.71	0	No	No	3	5	2	1
L:L:A11	R:R:S368	3.42	0	No	No	0	5	0	1
R:R:I372	R:R:I375	4.42	0	Yes	No	4	6	1	2
R:R:H376	R:R:I372	5.3	3	No	Yes	5	4	2	1
L:L:W14	R:R:I372	19.97	1	Yes	Yes	0	4	0	1
L:L:E10	R:R:R365	2.33	0	No	No	0	3	0	1
R:R:G118	R:R:T119	1.82	0	No	No	4	4	1	2
R:R:L113	R:R:P114	1.64	0	No	No	5	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XOW_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	258
Number of Links	277
Number of Hubs	28
Number of Links mediated by Hubs	119
Number of Communities	4
Number of Nodes involved in Communities	35
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	41718
Length Of Smallest Path	3
Average Path Length	16.082
Length of Longest Path	36
Minimum Path Strength	1.315
Average Path Strength	6.34448
Maximum Path Strength	15.805
Minimum Path Correlation	0.7
Average Path Correlation	0.918092
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	38.3656
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.5378
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32239
Sequence	>7XOW_nogp_Chain_R E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S R R L R T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G T F I F G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R P L Q A R V W Q T R S H A A R V I V A T W L L S G L L M V P Y P V Y T V V Q P V G P R V L Q C V H R W P S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G P G A H R A L S G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R F R Q A C L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XOW	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-	chim(NtGi1-Gq)/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOW (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-		3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	8IA7	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gq)/β1/γ2	3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	8IA7 (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-		3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	7F8V	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	Gi2/β1/γ2	3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8V (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	chim(NtGsL-Gq)/β1/γ2	3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XOW_nogp.zip

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