psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:G2	7.32	No	No	3	0	0
2	L:L:?1	L:L:P3	3.51	No	No	3	0	0
3	L:L:G2	L:L:P3	4.06	No	No	3	0	0
4	L:L:W4	R:R:N115	5.65	No	No	0	0	5
5	L:L:W4	R:R:Q204	8.76	No	No	0	0	4
6	L:L:L5	L:L:Y12	3.52	No	Yes	0	0	0
7	L:L:E8	L:L:E9	8.88	No	No	0	0	0
8	L:L:E10	L:L:Y12	12.35	No	Yes	0	0	0
9	L:L:A11	R:R:P361	3.74	No	No	0	0	1
10	L:L:A11	R:R:H364	5.85	No	Yes	0	0	1
11	L:L:Y12	R:R:V198	3.79	Yes	No	4	0	1
12	L:L:Y12	R:R:Q204	10.15	Yes	No	4	0	4
13	L:L:G13	R:R:R356	3	No	Yes	1	0	4
14	L:L:G13	R:R:H364	3.18	No	Yes	1	0	1
15	L:L:W14	R:R:R356	9	No	Yes	0	0	4
16	L:L:W14	R:R:I372	22.31	No	No	0	0	4
17	L:L:W14	R:R:H376	5.29	No	No	0	0	5
18	L:L:M15	R:R:F120	3.73	No	No	0	0	8
19	L:L:M15	R:R:H207	7.88	No	Yes	0	0	5
20	L:L:?17	L:L:D16	7.7	Yes	Yes	1	0	0
21	L:L:D16	R:R:Y189	6.9	Yes	Yes	1	0	7
22	L:L:D16	R:R:N353	13.46	Yes	No	1	0	7
23	L:L:D16	R:R:R356	9.53	Yes	Yes	1	0	4
24	L:L:?17	R:R:T111	3.58	Yes	No	1	0	7
25	L:L:?17	R:R:M134	8.02	Yes	Yes	0	0	8
26	L:L:?17	R:R:V138	19.31	Yes	No	0	0	7
27	L:L:?17	R:R:Y380	3.8	Yes	Yes	1	0	7
28	R:R:F374	R:R:I56	3.77	No	No	0	5	4
29	R:R:N115	R:R:R57	3.62	No	Yes	0	5	5
30	R:R:A370	R:R:R57	5.53	No	Yes	0	3	5
31	R:R:R57	R:R:S373	10.54	Yes	No	0	5	5
32	R:R:F374	R:R:R57	3.21	No	Yes	0	5	5
33	R:R:L377	R:R:L60	4.15	No	No	0	7	6
34	R:R:L112	R:R:Y61	15.24	No	Yes	0	6	7
35	R:R:S373	R:R:Y61	5.09	No	Yes	0	5	7
36	R:R:L377	R:R:Y61	15.24	No	Yes	0	7	7
37	R:R:Y380	R:R:Y61	5.96	Yes	Yes	0	7	7
38	R:R:C384	R:R:I64	6.55	No	No	0	5	7
39	R:R:F65	R:R:M108	8.71	No	No	0	7	7
40	R:R:L66	R:R:M67	4.24	No	No	0	5	4
41	R:R:C384	R:R:S68	3.44	No	No	0	5	8
42	R:R:F392	R:R:G71	3.01	No	No	0	6	8
43	R:R:I76	R:R:N72	4.25	No	No	5	8	9
44	R:R:A97	R:R:N72	4.69	No	No	5	9	9
45	R:R:L101	R:R:N72	15.1	No	No	0	8	9
46	R:R:M73	R:R:V77	3.04	No	No	0	4	4
47	R:R:A97	R:R:I75	3.25	No	Yes	0	9	9
48	R:R:I75	R:R:P387	3.39	Yes	No	0	9	9
49	R:R:C391	R:R:I75	4.91	No	Yes	0	7	9
50	R:R:F392	R:R:I75	7.54	No	Yes	0	6	9
51	R:R:A97	R:R:I76	3.25	No	No	5	9	8
52	R:R:T404	R:R:V78	6.35	No	No	0	7	8
53	R:R:L79	R:R:L94	4.15	No	No	0	8	7
54	R:R:R86	R:R:S82	15.81	No	No	0	8	6
55	R:R:L85	R:R:N90	4.12	No	No	0	8	9
56	R:R:R168	R:R:R86	9.6	No	No	0	4	8
57	R:R:T87	R:R:T89	4.71	No	No	0	7	8
58	R:R:N90	R:R:T87	7.31	No	No	0	9	7
59	R:R:E151	R:R:V88	4.28	Yes	No	0	9	6
60	R:R:A171	R:R:V88	3.39	No	No	0	7	6
61	R:R:L93	R:R:T89	2.95	No	No	0	8	8
62	R:R:A91	R:R:R168	4.15	No	No	0	6	4
63	R:R:A147	R:R:F92	4.16	No	Yes	0	7	8
64	R:R:F92	R:R:I148	3.77	Yes	Yes	0	8	9
65	R:R:E151	R:R:F92	5.83	Yes	Yes	0	9	8
66	R:R:F92	R:R:V174	5.24	Yes	No	0	8	6
67	R:R:F92	R:R:I175	15.07	Yes	No	0	8	7
68	R:R:L93	R:R:Y390	4.69	No	Yes	0	8	9
69	R:R:C391	R:R:L93	6.35	No	No	0	7	8
70	R:R:I175	R:R:S95	9.29	No	No	0	7	9
71	R:R:D100	R:R:L96	8.14	No	No	0	9	9
72	R:R:L96	R:R:S144	10.51	No	No	0	9	8
73	R:R:S99	R:R:V140	6.46	No	Yes	0	9	8
74	R:R:S141	R:R:S99	4.89	No	No	0	9	9
75	R:R:D100	R:R:S141	4.42	No	No	0	9	9
76	R:R:C107	R:R:L103	3.17	No	No	0	7	7
77	R:R:L103	R:R:S137	6.01	No	No	0	7	7
78	R:R:A106	R:R:L133	4.73	No	No	0	5	5
79	R:R:C107	R:R:M134	6.48	No	Yes	0	7	8
80	R:R:C107	R:R:Y380	4.03	No	Yes	0	7	7
81	R:R:M108	R:R:Y380	5.99	No	Yes	0	7	7
82	R:R:F110	R:R:P109	5.78	No	No	0	6	8
83	R:R:F110	R:R:V130	6.55	No	No	0	6	6
84	R:R:T111	R:R:Y380	3.75	No	Yes	1	7	7
85	R:R:L113	R:R:M117	7.07	No	No	0	5	5
86	R:R:F120	R:R:P114	8.67	No	No	0	8	5
87	R:R:F120	R:R:L203	4.87	No	No	0	8	3
88	R:R:F122	R:R:I126	5.02	No	No	0	6	5
89	R:R:T124	R:R:V195	4.76	No	Yes	0	4	4
90	R:R:C127	R:R:C205	7.28	No	No	0	9	9
91	R:R:K128	R:R:T193	4.5	No	No	0	7	6
92	R:R:M134	R:R:V130	3.04	Yes	No	0	8	6
93	R:R:S131	R:R:Y189	6.36	No	Yes	1	5	7
94	R:R:S131	R:R:T193	9.59	No	No	1	5	6
95	R:R:H207	R:R:S131	8.37	Yes	No	1	5	5
96	R:R:P190	R:R:Y132	12.52	No	No	0	6	6
97	R:R:S182	R:R:V136	3.23	Yes	No	0	8	6
98	R:R:V138	R:R:W346	6.13	No	Yes	0	7	8
99	R:R:S139	R:R:S182	3.26	No	Yes	0	8	8
100	R:R:L226	R:R:S139	3	Yes	No	0	8	8
101	R:R:V140	R:R:W179	15.94	Yes	No	0	8	9
102	R:R:S182	R:R:V140	3.23	Yes	Yes	0	8	8
103	R:R:L226	R:R:T142	2.95	Yes	No	0	8	8
104	R:R:L143	R:R:T178	2.95	No	No	0	6	7
105	R:R:I148	R:R:S144	3.1	Yes	No	0	9	8
106	R:R:L145	R:R:M234	7.07	No	No	0	9	8
107	R:R:L145	R:R:N386	6.87	No	No	0	9	9
108	R:R:L145	R:R:Y390	4.69	No	Yes	0	9	9
109	R:R:L150	R:R:V146	2.98	No	No	7	6	8
110	R:R:P230	R:R:V146	3.53	No	No	0	9	8
111	R:R:V146	R:R:V233	3.21	No	No	7	8	6
112	R:R:I148	R:R:R152	3.76	Yes	No	2	9	9
113	R:R:I148	R:R:Y390	3.63	Yes	Yes	2	9	9
114	R:R:A149	R:R:Y238	4	No	Yes	0	9	9
115	R:R:L150	R:R:V233	2.98	No	No	7	6	6
116	R:R:E151	R:R:Q166	12.74	Yes	Yes	0	9	7
117	R:R:E151	R:R:H170	4.92	Yes	Yes	0	9	7
118	R:R:R152	R:R:Y238	8.23	No	Yes	2	9	9
119	R:R:R152	R:R:Y390	8.23	No	Yes	2	9	9
120	R:R:C157	R:R:Y153	5.38	No	No	8	7	8
121	R:R:L240	R:R:Y153	8.21	No	No	8	6	8
122	R:R:I156	R:R:I241	5.89	No	No	0	8	9
123	R:R:C157	R:R:L240	3.17	No	No	8	7	6
124	R:R:C157	R:R:E244	4.56	No	No	0	7	6
125	R:R:Q161	R:R:R158	4.67	No	No	0	5	6
126	R:R:Q161	R:R:W165	7.67	No	Yes	0	5	5
127	R:R:A162	R:R:Q166	4.55	No	Yes	0	7	7
128	R:R:Q166	R:R:W165	5.48	Yes	Yes	0	7	5
129	R:R:H170	R:R:W165	15.87	Yes	Yes	0	7	5
130	R:R:S169	R:R:T167	3.2	No	No	0	6	8
131	R:R:H170	R:R:V174	6.92	Yes	No	0	7	6
132	R:R:L180	R:R:V176	4.47	No	No	0	4	4
133	R:R:M186	R:R:Y189	4.79	No	Yes	0	8	7
134	R:R:P188	R:R:V187	3.53	No	No	0	9	4
135	R:R:H207	R:R:Y189	9.8	Yes	Yes	1	5	7
136	R:R:W209	R:R:Y189	3.86	Yes	Yes	1	6	7
137	R:R:W218	R:R:Y189	4.82	No	Yes	1	7	7
138	R:R:H207	R:R:T193	8.21	Yes	No	1	5	6
139	R:R:Q196	R:R:V194	4.3	No	No	0	3	4
140	R:R:P197	R:R:V195	3.53	No	Yes	0	1	4
141	R:R:L203	R:R:V195	7.45	No	Yes	0	3	4
142	R:R:C205	R:R:V195	3.42	No	Yes	0	9	4
143	R:R:Q196	R:R:R208	8.18	No	No	0	3	2
144	R:R:V198	R:R:V202	3.21	No	No	0	1	1
145	R:R:Q204	R:R:V198	10.03	No	No	4	4	1
146	R:R:G199	R:R:P200	4.06	No	No	0	1	3
147	R:R:H207	R:R:W209	4.23	Yes	Yes	1	5	6
148	R:R:R215	R:R:W209	9	No	Yes	0	5	6
149	R:R:W209	R:R:W218	6.56	Yes	No	1	6	7
150	R:R:S211	R:R:V214	6.46	No	No	0	5	4
151	R:R:Q216	R:R:R213	3.5	No	No	0	4	5
152	R:R:F358	R:R:Q216	4.68	No	No	0	5	4
153	R:R:L222	R:R:W218	12.53	No	No	0	7	7
154	R:R:A357	R:R:S219	3.42	No	No	0	6	6
155	R:R:L222	R:R:L226	4.15	No	Yes	0	7	8
156	R:R:L223	R:R:T354	4.42	No	No	0	7	6
157	R:R:F228	R:R:L224	3.65	No	No	0	5	4
158	R:R:L226	R:R:Y350	8.21	Yes	Yes	0	8	7
159	R:R:F227	R:R:F343	5.36	No	No	0	8	6
160	R:R:F227	R:R:L347	3.65	No	No	0	8	7
161	R:R:F227	R:R:Y350	12.38	No	Yes	0	8	7
162	R:R:I229	R:R:P230	3.39	No	No	0	6	9
163	R:R:F342	R:R:G231	3.01	No	No	0	9	6
164	R:R:F343	R:R:G231	4.52	No	No	0	6	6
165	R:R:M234	R:R:Y238	3.59	No	Yes	0	8	9
166	R:R:L335	R:R:Y238	15.24	No	Yes	0	8	9
167	R:R:V339	R:R:Y238	5.05	No	Yes	0	8	9
168	R:R:Y238	R:R:Y390	4.96	Yes	Yes	2	9	9
169	R:R:L240	R:R:R243	4.86	No	No	0	6	5
170	R:R:S242	R:R:V332	6.46	No	No	0	6	7
171	R:R:K328	R:R:L245	9.87	Yes	No	0	8	8
172	R:R:L245	R:R:V331	4.47	No	No	0	8	8
173	R:R:K328	R:R:Y246	7.17	Yes	No	0	8	6
174	R:R:V332	R:R:Y246	7.57	No	No	0	7	6
175	R:R:K328	R:R:L249	11.28	Yes	No	0	8	5
176	R:R:K328	R:R:L326	4.23	Yes	No	0	8	5
177	R:R:A327	R:R:R330	4.15	No	No	0	7	8
178	R:R:M334	R:R:V389	3.04	Yes	No	0	8	8
179	R:R:M334	R:R:M393	5.78	Yes	No	0	8	7
180	R:R:H394	R:R:M334	6.57	No	Yes	0	8	8
181	R:R:I338	R:R:V389	6.14	No	No	0	8	8
182	R:R:I338	R:R:Y390	8.46	No	Yes	0	8	9
183	R:R:C345	R:R:L341	3.17	No	No	0	8	6
184	R:R:L341	R:R:V385	2.98	No	No	0	6	7
185	R:R:F342	R:R:W346	7.02	No	Yes	0	9	8
186	R:R:C345	R:R:S382	5.16	No	Yes	0	8	9
187	R:R:W346	R:R:Y350	6.75	Yes	Yes	0	8	7
188	R:R:S379	R:R:W346	11.12	No	Yes	6	7	8
189	R:R:S382	R:R:W346	8.65	Yes	Yes	6	9	8
190	R:R:L347	R:R:P348	3.28	No	No	0	7	9
191	R:R:I375	R:R:P348	6.77	No	No	0	6	9
192	R:R:I375	R:R:V349	3.07	No	No	0	6	7
193	R:R:S379	R:R:V349	3.23	No	No	0	7	7
194	R:R:N353	R:R:R356	6.03	No	Yes	1	7	4
195	R:R:D359	R:R:W355	16.75	No	No	0	4	5
196	R:R:A363	R:R:W355	5.19	No	No	0	3	5
197	R:R:L367	R:R:W355	3.42	No	No	0	4	5
198	R:R:H364	R:R:R356	4.51	Yes	Yes	1	1	4
199	R:R:G360	R:R:P361	4.06	No	No	0	1	1
200	R:R:G360	R:R:H364	3.18	No	Yes	0	1	1
201	R:R:G362	R:R:R365	6	No	No	0	4	3
202	R:R:H376	R:R:Y380	4.36	No	Yes	0	5	7
203	R:R:S379	R:R:S382	3.26	No	Yes	6	7	9
204	R:R:C391	R:R:F397	8.38	No	No	0	7	8
205	R:R:C401	R:R:T404	3.38	No	No	0	7	7
206	R:R:I121	R:R:M117	2.92	No	No	0	4	5
207	R:R:G135	R:R:Y189	2.9	No	Yes	0	6	7
208	R:R:Q166	R:R:S154	2.89	Yes	No	0	7	5
209	R:R:I64	R:R:L377	2.85	No	No	0	7	7
210	R:R:I75	R:R:L79	2.85	Yes	No	0	9	8
211	R:R:I241	R:R:L335	2.85	No	No	0	9	8
212	R:R:L116	R:R:M117	2.83	No	No	0	5	5
213	R:R:P188	R:R:Y192	2.78	No	No	0	9	4
214	R:R:P210	R:R:Y192	2.78	No	No	0	4	4
215	R:R:L221	R:R:L225	2.77	No	No	0	4	5
216	R:R:A237	R:R:Y153	2.67	No	No	0	6	8
217	R:R:R173	R:R:S169	2.64	No	No	0	4	6
218	R:R:F65	R:R:V69	2.62	No	No	0	7	6
219	R:R:F397	R:R:V78	2.62	No	No	0	8	8
220	L:L:?1	R:R:R57	2.6	No	Yes	0	0	5
221	L:L:E7	L:L:E8	2.54	No	No	0	0	0
222	R:R:V191	R:R:Y192	2.52	No	No	0	4	4
223	R:R:V164	R:R:W165	2.45	No	Yes	0	4	5
224	R:R:F392	R:R:L74	2.44	No	No	0	6	7
225	L:L:L5	R:R:R365	2.43	No	No	0	0	3
226	R:R:K329	R:R:Y246	2.39	No	No	0	6	6
227	R:R:L223	R:R:Y350	2.34	No	Yes	0	7	7
228	R:R:F110	R:R:F122	2.14	No	No	0	6	6
229	R:R:G70	R:R:G71	2.11	No	No	0	4	8
230	R:R:G231	R:R:P230	2.03	No	No	0	6	9
231	R:R:A370	R:R:P371	1.87	No	No	0	3	5
232	R:R:G183	R:R:S182	1.86	No	Yes	0	5	8
233	R:R:G369	R:R:S368	1.86	No	No	0	3	5
234	L:L:G13	R:R:V206	1.84	No	No	0	0	4
235	R:R:G118	R:R:T119	1.82	No	No	0	4	4
236	R:R:C401	R:R:C405	1.82	No	No	0	7	6
237	R:R:A171	R:R:A91	1.79	No	No	0	7	6
238	R:R:A149	R:R:A237	1.79	No	No	0	9	6
239	R:R:G70	R:R:M73	1.75	No	No	0	4	4
240	R:R:A104	R:R:S68	1.71	No	No	0	7	8
241	R:R:A383	R:R:S382	1.71	No	Yes	0	9	9
242	R:R:G369	R:R:N115	1.7	No	No	0	3	5
243	R:R:A235	R:R:V339	1.7	No	No	0	5	8
244	R:R:D359	R:R:G360	1.68	No	No	0	4	1
245	R:R:L113	R:R:P114	1.64	No	No	0	5	5
246	R:R:L378	R:R:P348	1.64	No	No	0	7	9
247	R:R:A381	R:R:I64	1.62	No	No	0	5	7
248	R:R:A155	R:R:I156	1.62	No	No	0	8	8
249	R:R:A352	R:R:I375	1.62	No	No	0	5	6
250	R:R:A106	R:R:M134	1.61	No	Yes	0	5	8
251	R:R:S351	R:R:T354	1.6	No	No	0	6	6
252	R:R:T124	R:R:V125	1.59	No	No	0	4	3
253	R:R:T178	R:R:V140	1.59	No	Yes	0	7	8
254	R:R:T178	R:R:V174	1.59	No	No	0	7	6
255	R:R:P197	R:R:Q196	1.58	No	No	0	1	3
256	L:L:E6	L:L:P3	1.57	No	No	0	0	0
257	R:R:I76	R:R:V98	1.54	No	No	0	8	7
258	R:R:I56	R:R:T59	1.52	No	No	0	4	3
259	R:R:I58	R:R:T59	1.52	No	No	0	6	3
260	R:R:M67	R:R:V63	1.52	No	No	0	4	5
261	R:R:K128	R:R:V191	1.52	No	No	0	7	4
262	R:R:M334	R:R:V337	1.52	Yes	No	0	8	7
263	R:R:F122	R:R:G123	1.51	No	No	0	6	7
264	R:R:A400	R:R:E403	1.51	No	No	0	8	5
265	R:R:L102	R:R:S137	1.5	No	No	0	7	7
266	R:R:L335	R:R:S242	1.5	No	No	0	8	6
267	R:R:L102	R:R:V105	1.49	No	No	0	7	5
268	R:R:L223	R:R:V220	1.49	No	No	0	7	5
269	R:R:L203	R:R:T119	1.47	No	No	0	3	4
270	R:R:G183	R:R:Y132	1.45	No	No	0	5	6
271	R:R:P159	R:R:R158	1.44	No	No	0	9	6
272	R:R:I229	R:R:L224	1.43	No	No	0	6	4
273	R:R:I229	R:R:L225	1.43	No	No	0	6	5
274	R:R:Q216	R:R:T217	1.42	No	No	0	4	5
275	R:R:L388	R:R:M393	1.41	No	No	0	7	7
276	R:R:A357	R:R:F358	1.39	No	No	0	6	5
277	R:R:L181	R:R:L185	1.38	No	No	0	5	6
278	R:R:L184	R:R:L185	1.38	No	No	0	4	6
279	R:R:H170	R:R:T167	1.37	Yes	No	0	7	8
280	R:R:E244	R:R:L247	1.33	No	No	0	6	5
281	R:R:R213	R:R:S211	1.32	No	No	0	5	5
282	L:L:E10	L:L:E7	1.27	No	No	0	0	0
283	R:R:V214	R:R:W209	1.23	No	Yes	0	4	6
284	R:R:L85	R:R:R83	1.21	No	No	0	8	7
285	R:R:L336	R:R:R333	1.21	No	No	0	6	6
286	R:R:L180	R:R:W179	1.14	No	No	0	4	9
287	R:R:R395	R:R:R398	1.07	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y12	7.4525	4	4	0
2	L:L:D16	9.3975	4	1	0
3	L:L:?17	8.482	5	1	0
4	R:R:R57	5.1	5	0	5
5	R:R:Y61	10.3825	4	0	7
6	R:R:I75	4.388	5	0	9
7	R:R:F92	6.814	5	0	8
8	R:R:M134	4.7875	4	0	8
9	R:R:V140	6.805	4	0	8
10	R:R:I148	3.565	4	2	9
11	R:R:E151	6.9425	4	0	9
12	R:R:W165	7.8675	4	0	5
13	R:R:Q166	6.415	4	0	7
14	R:R:H170	7.27	4	0	7
15	R:R:S182	2.895	4	0	8
16	R:R:Y189	5.63286	7	1	7
17	R:R:V195	4.79	4	0	4
18	R:R:H207	7.698	5	1	5
19	R:R:W209	4.976	5	1	6
20	R:R:L226	4.5775	4	0	8
21	R:R:Y238	6.845	6	2	9
22	R:R:K328	8.1375	4	0	8
23	R:R:M334	4.2275	4	0	8
24	R:R:W346	7.934	5	6	8
25	R:R:Y350	7.42	4	0	7
26	R:R:R356	6.414	5	1	4
27	R:R:H364	4.18	4	1	1
28	R:R:Y380	4.64833	6	1	7
29	R:R:S382	4.695	4	6	9
30	R:R:Y390	5.77667	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N115	R:R:R57	15.984	3.62	No	Yes	0	5	5
2	L:L:W4	R:R:N115	13.0076	5.65	No	No	0	0	5
3	L:L:W4	R:R:Q204	11.9715	8.76	No	No	0	0	4
4	R:R:R57	R:R:S373	26.7942	10.54	Yes	No	0	5	5
5	R:R:S373	R:R:Y61	27.6182	5.09	No	Yes	0	5	7
6	R:R:Y380	R:R:Y61	35.7267	5.96	Yes	Yes	0	7	7
7	L:L:?17	R:R:Y380	40.5459	3.8	Yes	Yes	1	0	7
8	L:L:?17	L:L:D16	19.1516	7.7	Yes	Yes	1	0	0
9	L:L:D16	R:R:R356	13.4214	9.53	Yes	Yes	1	0	4
10	R:R:H364	R:R:R356	10.6085	4.51	Yes	Yes	1	1	4
11	L:L:D16	R:R:Y189	24.7601	6.9	Yes	Yes	1	0	7
12	R:R:H207	R:R:Y189	24.388	9.8	Yes	Yes	1	5	7
13	L:L:M15	R:R:H207	28.717	7.88	No	Yes	0	0	5
14	L:L:M15	R:R:F120	27.4478	3.73	No	No	0	0	8
15	L:L:?17	R:R:M134	13.3171	8.02	Yes	Yes	0	0	8
16	L:L:?17	R:R:V138	44.5897	19.31	Yes	No	0	0	7
17	R:R:V138	R:R:W346	44.774	6.13	No	Yes	0	7	8
18	R:R:W346	R:R:Y350	46.6412	6.75	Yes	Yes	0	8	7
19	R:R:L226	R:R:Y350	57.7677	8.21	Yes	Yes	0	8	7
20	R:R:L226	R:R:S139	100	3	Yes	No	0	8	8
21	R:R:S139	R:R:S182	99.8018	3.26	No	Yes	0	8	8
22	R:R:S182	R:R:V140	98.7065	3.23	Yes	Yes	0	8	8
23	R:R:T178	R:R:V140	94.6697	1.59	No	Yes	0	7	8
24	R:R:T178	R:R:V174	94.0716	1.59	No	No	0	7	6
25	R:R:F92	R:R:V174	80.3338	5.24	Yes	No	0	8	6
26	R:R:F92	R:R:I148	78.8769	3.77	Yes	Yes	0	8	9
27	R:R:I148	R:R:Y390	55.6919	3.63	Yes	Yes	2	9	9
28	R:R:L93	R:R:Y390	27.2497	4.69	No	Yes	0	8	9
29	R:R:C391	R:R:L93	21.6377	6.35	No	No	0	7	8
30	R:R:C391	R:R:I75	15.8727	4.91	No	Yes	0	7	9
31	R:R:E151	R:R:F92	15.4485	5.83	Yes	Yes	0	9	8
32	R:R:E151	R:R:V88	11.356	4.28	Yes	No	0	9	6
33	R:R:H170	R:R:V174	19.3255	6.92	Yes	No	0	7	6
34	R:R:E151	R:R:H170	10.5563	4.92	Yes	Yes	0	9	7
35	R:R:F120	R:R:L203	18.6857	4.87	No	No	0	8	3
36	R:R:L203	R:R:V195	14.1064	7.45	No	Yes	0	3	4
37	R:R:K128	R:R:T193	14.854	4.5	No	No	0	7	6
38	R:R:H207	R:R:T193	10.9423	8.21	Yes	No	1	5	6
39	R:R:I148	R:R:R152	23.0042	3.76	Yes	No	2	9	9
40	R:R:R152	R:R:Y238	22.2601	8.23	No	Yes	2	9	9
41	R:R:Y238	R:R:Y390	25.2051	4.96	Yes	Yes	2	9	9
42	R:R:F342	R:R:W346	11.8324	7.02	No	Yes	0	9	8
43	R:R:F342	R:R:G231	10.8102	3.01	No	No	0	9	6
44	R:R:G231	R:R:P230	14.7949	2.03	No	No	0	6	9
45	R:R:A149	R:R:Y238	15.7545	4	No	Yes	0	9	9
46	R:R:A149	R:R:A237	13.7865	1.79	No	No	0	9	6
47	R:R:A237	R:R:Y153	11.8115	2.67	No	No	0	6	8
48	R:R:L335	R:R:Y238	25.5563	15.24	No	Yes	0	8	9
49	R:R:K128	R:R:V191	12.3783	1.52	No	No	0	7	4
50	R:R:W218	R:R:Y189	28.9499	4.82	No	Yes	1	7	7
51	R:R:L222	R:R:W218	50.5946	12.53	No	No	0	7	7
52	R:R:F227	R:R:Y350	12.3157	12.38	No	Yes	0	8	7
53	R:R:L335	R:R:S242	17.8894	1.5	No	No	0	8	6
54	R:R:S242	R:R:V332	15.9284	6.46	No	No	0	6	7
55	R:R:V332	R:R:Y246	13.9569	7.57	No	No	0	7	6
56	R:R:L222	R:R:L226	50.7197	4.15	No	Yes	0	7	8
57	R:R:H207	R:R:W209	15.751	4.23	Yes	Yes	1	5	6
58	R:R:W209	R:R:W218	21.4534	6.56	Yes	No	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:W4	R:R:N115	5.65	0	No	No	0	5	0	1
L:L:W4	R:R:Q204	8.76	0	No	No	0	4	0	1
L:L:A11	R:R:P361	3.74	0	No	No	0	1	0	1
L:L:A11	R:R:H364	5.85	0	No	Yes	0	1	0	1
L:L:Y12	R:R:V198	3.79	4	Yes	No	0	1	0	1
L:L:Y12	R:R:Q204	10.15	4	Yes	No	0	4	0	1
L:L:G13	R:R:R356	3	1	No	Yes	0	4	0	1
L:L:G13	R:R:H364	3.18	1	No	Yes	0	1	0	1
L:L:W14	R:R:R356	9	0	No	Yes	0	4	0	1
L:L:W14	R:R:I372	22.31	0	No	No	0	4	0	1
L:L:W14	R:R:H376	5.29	0	No	No	0	5	0	1
L:L:M15	R:R:F120	3.73	0	No	No	0	8	0	1
L:L:M15	R:R:H207	7.88	0	No	Yes	0	5	0	1
L:L:D16	R:R:Y189	6.9	1	Yes	Yes	0	7	0	1
L:L:D16	R:R:N353	13.46	1	Yes	No	0	7	0	1
L:L:D16	R:R:R356	9.53	1	Yes	Yes	0	4	0	1
L:L:?17	R:R:T111	3.58	1	Yes	No	0	7	0	1
L:L:?17	R:R:M134	8.02	1	Yes	Yes	0	8	0	1
L:L:?17	R:R:V138	19.31	1	Yes	No	0	7	0	1
L:L:?17	R:R:Y380	3.8	1	Yes	Yes	0	7	0	1
R:R:N115	R:R:R57	3.62	0	No	Yes	5	5	1	1
R:R:A370	R:R:R57	5.53	0	No	Yes	3	5	2	1
R:R:R57	R:R:S373	10.54	0	Yes	No	5	5	1	2
R:R:F374	R:R:R57	3.21	0	No	Yes	5	5	2	1
R:R:S373	R:R:Y61	5.09	0	No	Yes	5	7	2	2
R:R:Y380	R:R:Y61	5.96	1	Yes	Yes	7	7	1	2
R:R:C107	R:R:M134	6.48	0	No	Yes	7	8	2	1
R:R:C107	R:R:Y380	4.03	0	No	Yes	7	7	2	1
R:R:M108	R:R:Y380	5.99	0	No	Yes	7	7	2	1
R:R:T111	R:R:Y380	3.75	1	No	Yes	7	7	1	1
R:R:F120	R:R:P114	8.67	0	No	No	8	5	1	2
R:R:F120	R:R:L203	4.87	0	No	No	8	3	1	2
R:R:M134	R:R:V130	3.04	0	Yes	No	8	6	1	2
R:R:S131	R:R:Y189	6.36	1	No	Yes	5	7	2	1
R:R:S131	R:R:T193	9.59	1	No	No	5	6	2	2
R:R:H207	R:R:S131	8.37	1	Yes	No	5	5	1	2
R:R:V138	R:R:W346	6.13	0	No	Yes	7	8	1	2
R:R:M186	R:R:Y189	4.79	0	No	Yes	8	7	2	1
R:R:H207	R:R:Y189	9.8	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y189	3.86	1	Yes	Yes	6	7	2	1
R:R:W218	R:R:Y189	4.82	1	No	Yes	7	7	2	1
R:R:H207	R:R:T193	8.21	1	Yes	No	5	6	1	2
R:R:V198	R:R:V202	3.21	4	No	No	1	1	1	2
R:R:Q204	R:R:V198	10.03	4	No	No	4	1	1	1
R:R:H207	R:R:W209	4.23	1	Yes	Yes	5	6	1	2
R:R:W209	R:R:W218	6.56	1	Yes	No	6	7	2	2
R:R:N353	R:R:R356	6.03	1	No	Yes	7	4	1	1
R:R:H364	R:R:R356	4.51	1	Yes	Yes	1	4	1	1
R:R:G360	R:R:P361	4.06	0	No	No	1	1	2	1
R:R:G360	R:R:H364	3.18	0	No	Yes	1	1	2	1
R:R:G362	R:R:R365	6	0	No	No	4	3	2	1
R:R:H376	R:R:Y380	4.36	0	No	Yes	5	7	1	1
R:R:G135	R:R:Y189	2.9	0	No	Yes	6	7	2	1
L:L:?1	R:R:R57	2.6	3	No	Yes	0	5	0	1
L:L:L5	R:R:R365	2.43	0	No	No	0	3	0	1
L:L:G13	R:R:V206	1.84	1	No	No	0	4	0	1
R:R:G369	R:R:N115	1.7	0	No	No	3	5	2	1
R:R:A106	R:R:M134	1.61	0	No	Yes	5	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F8W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	270
Number of Links	287
Number of Hubs	30
Number of Links mediated by Hubs	115
Number of Communities	8
Number of Nodes involved in Communities	36
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	59
Number Of Links MetaPath	58
Number of Shortest Paths	51072
Length Of Smallest Path	3
Average Path Length	15.0701
Length of Longest Path	33
Minimum Path Strength	1.38
Average Path Strength	5.47084
Maximum Path Strength	15.24
Minimum Path Correlation	0.7
Average Path Correlation	0.924176
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	43.7627
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.9053
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • molecular function regulator activity • 1-phosphatidylinositol-3-kinase regulator activity • kinase regulator activity • protein binding • binding • signaling receptor binding • type B gastrin/cholecystokinin receptor binding • G protein-coupled receptor binding • cholecystokinin receptor binding • neuropeptide receptor binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • gastrin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • cholecystokinin receptor activity • localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus
Gene Ontology	Biological Process	• localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cholecystokinin signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • developmental process • gland development • animal organ development • anatomical structure development • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organism development • digestive system development • tube development • digestive tract development • system development • chemical homeostasis • homeostatic process • regulation of pH • monoatomic ion homeostasis • monoatomic cation homeostasis • pH reduction • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • hormone activity • protein binding • binding • molecular function activator activity • signaling receptor binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • response to nutrient levels • response to food • response to chemical • extracellular region • extracellular space • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • nucleoside-triphosphatase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • G protein-coupled receptor binding • cation binding • metal ion binding • regulation of signaling • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • cytosolic region • postsynapse • postsynaptic cytosol
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	PCA
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	PCA
Name	Pidolic acid
Synonyms	L-pyroglutamic acid
Identifier
Formula	C5 H7 N O3
Molecular Weight	129.114
SMILES
PubChem	7405
Formal Charge	0
Total Atoms	16
Total Chiral Atoms	1
Total Bonds	16
Total Aromatic Bonds	0


Code	NFA
PDB Residues	L:L:?17
Environment Details	Open EMBL-EBI Page
Code	NFA
Name	Phenylalanylamide
Synonyms	Phenylalanine amide (S)-2-amino-3-phenylpropanamide Phenylalaninamide L-phenylalanine amide Phenylalanylamide
Identifier
Formula	C9 H12 N2 O
Molecular Weight	164.204
SMILES
PubChem	445694
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32239
Sequence	>7F8W_nogp_Chain_R A I R I T L Y A V I F L M S V G G N M L I I V V L G L S R R L R T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G T F I F G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R P L Q A R V W Q T R S H A A R V I V A T W L L S G L L M V P Y P V Y T V V Q P V G P R V L Q C V H R W P S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G P G A H R A L S G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R F R Q A C L E T C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XOW	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-	chim(NtGi1-Gq)/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOW (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-		3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	8IA7	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gq)/β1/γ2	3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	8IA7 (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-		3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	7F8V	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	Gi2/β1/γ2	3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8V (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	chim(NtGsL-Gq)/β1/γ2	3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7F8W_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.