psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L54	R:R:R57	6.07	No	Yes	0	5	5
2	R:R:R57	R:R:Y61	4.12	Yes	Yes	3	5	7
3	R:R:L116	R:R:R57	3.64	No	Yes	0	5	5
4	R:R:R57	R:R:S373	11.86	Yes	No	3	5	5
5	R:R:F374	R:R:R57	7.48	No	Yes	0	5	5
6	R:R:I58	R:R:L116	4.28	No	No	0	6	5
7	R:R:L377	R:R:L60	5.54	No	No	0	7	6
8	R:R:L112	R:R:Y61	11.72	No	Yes	0	6	7
9	R:R:S373	R:R:Y61	7.63	No	Yes	3	5	7
10	R:R:L377	R:R:Y61	11.72	No	Yes	0	7	7
11	R:R:I64	R:R:M108	5.83	No	No	0	7	7
12	R:R:I64	R:R:L377	4.28	No	No	0	7	7
13	R:R:F65	R:R:M108	3.73	No	No	0	7	7
14	R:R:L66	R:R:M67	4.24	No	No	0	5	4
15	R:R:N72	R:R:S68	4.47	Yes	No	0	9	8
16	R:R:D100	R:R:N72	13.46	No	Yes	0	9	9
17	R:R:L101	R:R:N72	6.87	No	Yes	0	8	9
18	R:R:F392	R:R:L74	6.09	Yes	No	0	6	7
19	R:R:C391	R:R:I75	8.18	No	Yes	0	7	9
20	R:R:F392	R:R:I75	10.05	Yes	Yes	0	6	9
21	R:R:I76	R:R:V98	4.61	No	No	0	8	7
22	R:R:L79	R:R:N90	5.49	No	No	0	8	9
23	R:R:R84	R:R:S82	5.27	No	No	2	5	6
24	R:R:L85	R:R:S82	9.01	Yes	No	2	8	6
25	R:R:Q399	R:R:S82	8.66	Yes	No	2	6	6
26	R:R:R83	R:R:R86	4.26	No	No	0	7	8
27	R:R:L85	R:R:R84	4.86	Yes	No	2	8	5
28	R:R:Q399	R:R:R84	7.01	Yes	No	2	6	5
29	R:R:L85	R:R:N90	5.49	Yes	No	0	8	9
30	R:R:L85	R:R:Q399	6.65	Yes	Yes	2	8	6
31	R:R:R168	R:R:R86	7.46	No	No	0	4	8
32	R:R:T87	R:R:T89	4.71	No	No	0	7	8
33	R:R:N90	R:R:T87	10.24	No	No	0	9	7
34	R:R:A147	R:R:F92	4.16	No	Yes	0	7	8
35	R:R:F92	R:R:I148	3.77	Yes	No	0	8	9
36	R:R:E151	R:R:F92	8.16	No	Yes	0	9	8
37	R:R:A171	R:R:F92	4.16	No	Yes	0	7	8
38	R:R:F92	R:R:V174	5.24	Yes	No	0	8	6
39	R:R:F92	R:R:I175	3.77	Yes	No	0	8	7
40	R:R:L93	R:R:Y390	4.69	No	Yes	0	8	9
41	R:R:C391	R:R:L93	4.76	No	No	0	7	8
42	R:R:I175	R:R:S95	6.19	No	No	0	7	9
43	R:R:S95	R:R:W179	6.18	No	No	0	9	9
44	R:R:L96	R:R:N386	6.87	No	No	0	9	9
45	R:R:S99	R:R:V140	4.85	No	No	5	9	8
46	R:R:S99	R:R:W179	3.71	No	No	5	9	9
47	R:R:D100	R:R:L103	4.07	No	No	0	9	7
48	R:R:A383	R:R:D100	4.63	No	No	0	9	9
49	R:R:L102	R:R:L133	5.54	No	No	0	7	5
50	R:R:L103	R:R:S137	7.51	No	No	0	7	7
51	R:R:A106	R:R:L133	4.73	No	No	0	5	5
52	R:R:C107	R:R:M134	6.48	No	No	0	7	8
53	R:R:C107	R:R:Y380	8.06	No	Yes	0	7	7
54	R:R:M108	R:R:Y380	3.59	No	Yes	0	7	7
55	R:R:F110	R:R:P109	7.22	No	No	0	6	8
56	R:R:F110	R:R:F122	10.72	No	Yes	0	6	6
57	R:R:F110	R:R:V130	13.11	No	No	0	6	6
58	R:R:T111	R:R:Y380	3.75	No	Yes	0	7	7
59	R:R:L112	R:R:L116	5.54	No	No	0	6	5
60	R:R:F120	R:R:P114	8.67	Yes	No	0	8	5
61	L:L:?2	R:R:P114	4.71	Yes	No	0	0	5
62	R:R:F120	R:R:F122	11.79	Yes	Yes	0	8	6
63	R:R:C127	R:R:F120	8.38	No	Yes	6	9	8
64	R:R:C205	R:R:F120	8.38	No	Yes	6	9	8
65	R:R:F122	R:R:I126	6.28	Yes	No	0	6	5
66	R:R:K128	R:R:T124	4.5	No	No	0	7	4
67	R:R:T124	R:R:V195	6.35	No	No	0	4	4
68	R:R:C127	R:R:C205	7.28	No	No	6	9	9
69	R:R:M134	R:R:V130	4.56	No	No	0	8	6
70	R:R:S131	R:R:Y189	3.82	No	Yes	0	5	7
71	R:R:P190	R:R:S131	3.56	No	No	0	6	5
72	R:R:S131	R:R:T193	6.4	No	No	0	5	6
73	R:R:V136	R:R:Y132	8.83	No	No	0	6	6
74	R:R:P190	R:R:Y132	9.74	No	No	0	6	6
75	L:L:?9	R:R:M134	14	No	No	0	0	8
76	R:R:G135	R:R:M186	6.99	No	No	0	6	8
77	R:R:S182	R:R:V136	4.85	No	No	0	8	6
78	R:R:V138	R:R:W346	6.13	No	Yes	0	7	8
79	L:L:F8	R:R:V138	6.55	Yes	No	0	0	7
80	R:R:S139	R:R:S182	6.52	No	No	0	8	8
81	R:R:V140	R:R:W179	14.71	No	No	5	8	9
82	R:R:S182	R:R:V140	4.85	No	No	0	8	8
83	R:R:P230	R:R:T142	3.5	No	No	0	9	8
84	R:R:F342	R:R:T142	3.89	No	No	0	9	8
85	R:R:L143	R:R:T178	4.42	No	No	0	6	7
86	R:R:L145	R:R:N386	4.12	No	No	0	9	9
87	R:R:L145	R:R:Y390	4.69	No	Yes	0	9	9
88	R:R:P230	R:R:V146	3.53	No	No	0	9	8
89	R:R:I148	R:R:R152	5.01	No	No	4	9	9
90	R:R:I148	R:R:Y390	3.63	No	Yes	4	9	9
91	R:R:A149	R:R:Y238	5.34	No	Yes	0	9	9
92	R:R:L150	R:R:V233	4.47	No	No	0	6	6
93	R:R:E151	R:R:Q166	5.1	No	Yes	0	9	7
94	R:R:E151	R:R:H170	8.62	No	No	0	9	7
95	R:R:R152	R:R:Y238	6.17	No	Yes	0	9	9
96	R:R:R152	R:R:Y390	7.2	No	Yes	4	9	9
97	R:R:C157	R:R:Y153	8.06	No	Yes	0	7	8
98	R:R:L240	R:R:Y153	5.86	No	Yes	0	6	8
99	R:R:S154	R:R:W165	4.94	No	Yes	0	5	5
100	R:R:A155	R:R:Q166	4.55	No	Yes	0	8	7
101	R:R:C157	R:R:E244	9.12	No	No	0	7	6
102	R:R:Q161	R:R:R158	7.01	No	No	0	5	6
103	R:R:A162	R:R:Q166	6.06	No	Yes	0	7	7
104	R:R:V164	R:R:W165	3.68	No	Yes	0	4	5
105	R:R:Q166	R:R:W165	8.76	Yes	Yes	0	7	5
106	R:R:H170	R:R:W165	8.46	No	Yes	0	7	5
107	R:R:H170	R:R:V174	5.54	No	No	0	7	6
108	R:R:R173	R:R:V176	3.92	No	No	0	4	4
109	R:R:L185	R:R:M186	4.24	No	No	0	6	8
110	R:R:L222	R:R:M186	4.24	No	No	0	7	8
111	R:R:P188	R:R:V187	5.3	No	No	0	9	4
112	R:R:P188	R:R:W218	6.76	No	Yes	0	9	7
113	R:R:H207	R:R:Y189	6.53	Yes	Yes	1	5	7
114	R:R:W209	R:R:Y189	3.86	Yes	Yes	1	6	7
115	R:R:W218	R:R:Y189	7.72	Yes	Yes	1	7	7
116	L:L:D7	R:R:Y189	12.64	No	Yes	1	0	7
117	L:L:F8	R:R:Y189	4.13	Yes	Yes	0	0	7
118	R:R:V191	R:R:Y192	7.57	No	No	0	4	4
119	R:R:W209	R:R:Y192	10.61	Yes	No	1	6	4
120	R:R:P210	R:R:Y192	18.08	No	No	1	4	4
121	R:R:H207	R:R:T193	5.48	Yes	No	0	5	6
122	R:R:R208	R:R:V194	11.77	No	No	0	2	4
123	R:R:C205	R:R:V195	6.83	No	No	0	9	4
124	R:R:Q196	R:R:V206	4.3	No	No	0	3	4
125	R:R:Q196	R:R:R208	4.67	No	No	0	3	2
126	R:R:L203	R:R:P197	4.93	No	No	0	3	1
127	R:R:Q204	R:R:V198	4.3	No	No	0	4	1
128	R:R:G199	R:R:P200	4.06	No	No	0	1	3
129	R:R:P200	R:R:R201	4.32	No	No	0	3	1
130	L:L:?2	R:R:Q204	7.64	Yes	No	0	0	4
131	R:R:H207	R:R:W209	4.23	Yes	Yes	1	5	6
132	L:L:M6	R:R:H207	6.57	No	Yes	0	0	5
133	L:L:D7	R:R:H207	7.56	No	Yes	1	0	5
134	R:R:P210	R:R:W209	4.05	No	Yes	1	4	6
135	R:R:R215	R:R:W209	7	No	Yes	0	5	6
136	R:R:W209	R:R:W218	7.5	Yes	Yes	1	6	7
137	R:R:P210	R:R:V214	5.3	No	No	0	4	4
138	R:R:Q216	R:R:R213	5.84	No	No	0	4	5
139	R:R:F358	R:R:Q216	5.86	No	No	0	5	4
140	R:R:L222	R:R:W218	14.81	No	Yes	0	7	7
141	R:R:L221	R:R:L225	4.15	No	No	0	4	5
142	R:R:F227	R:R:L223	3.65	Yes	No	0	8	7
143	R:R:L223	R:R:Y350	3.52	No	No	0	7	7
144	R:R:F228	R:R:L224	3.65	No	No	0	5	4
145	R:R:L226	R:R:Y350	5.86	No	No	0	8	7
146	R:R:F227	R:R:F343	6.43	Yes	No	0	8	6
147	R:R:F227	R:R:L347	6.09	Yes	No	0	8	7
148	R:R:F342	R:R:M234	3.73	No	No	0	9	8
149	R:R:L335	R:R:Y238	8.21	No	Yes	0	8	9
150	R:R:V339	R:R:Y238	5.05	No	Yes	0	8	9
151	R:R:S242	R:R:V332	8.08	No	No	0	6	7
152	R:R:K329	R:R:L325	4.23	No	No	0	6	4
153	R:R:H394	R:R:M334	6.57	No	No	0	8	8
154	R:R:I338	R:R:V389	4.61	No	Yes	0	8	8
155	R:R:L341	R:R:V385	4.47	No	No	0	6	7
156	R:R:F342	R:R:W346	7.02	No	Yes	0	9	8
157	R:R:C345	R:R:W346	3.92	No	Yes	0	8	8
158	R:R:W346	R:R:Y350	5.79	Yes	No	0	8	7
159	R:R:S379	R:R:W346	6.18	No	Yes	0	7	8
160	R:R:S382	R:R:W346	8.65	No	Yes	0	9	8
161	R:R:L347	R:R:P348	4.93	No	No	0	7	9
162	L:L:F8	R:R:V349	3.93	Yes	No	0	0	7
163	L:L:W5	R:R:A352	3.89	Yes	No	0	0	5
164	L:L:W5	R:R:N353	5.65	Yes	No	0	0	7
165	L:L:D7	R:R:N353	5.39	No	No	0	0	7
166	R:R:F358	R:R:T354	3.89	No	No	0	5	6
167	R:R:A363	R:R:W355	9.08	No	No	0	3	5
168	R:R:A366	R:R:W355	3.89	No	No	0	4	5
169	R:R:H364	R:R:R356	10.16	No	No	0	1	4
170	L:L:W5	R:R:R356	11	Yes	No	0	0	4
171	R:R:G360	R:R:P361	4.06	No	No	0	1	1
172	L:L:M3	R:R:H364	9.19	No	No	0	0	1
173	R:R:L367	R:R:P371	8.21	No	No	0	4	5
174	R:R:I372	R:R:L367	4.28	Yes	No	0	4	4
175	R:R:A370	R:R:P371	3.74	No	No	0	3	5
176	R:R:I372	R:R:I375	5.89	Yes	No	0	4	6
177	R:R:H376	R:R:I372	5.3	No	Yes	0	5	4
178	L:L:W5	R:R:I372	11.74	Yes	Yes	0	0	4
179	R:R:H376	R:R:Y380	6.53	No	Yes	0	5	7
180	R:R:S379	R:R:Y380	3.82	No	Yes	0	7	7
181	R:R:V389	R:R:Y390	3.79	Yes	Yes	0	8	9
182	R:R:C391	R:R:R396	5.57	No	No	0	7	7
183	R:R:F392	R:R:R396	4.28	Yes	No	0	6	7
184	R:R:H394	R:R:M393	9.19	No	No	0	8	7
185	R:R:E403	R:R:Q399	6.37	No	Yes	0	5	6
186	L:L:?2	L:L:M3	5.07	Yes	No	0	0	0
187	L:L:?2	L:L:G4	13.49	Yes	No	0	0	0
188	L:L:?9	L:L:F8	9.04	No	Yes	0	0	0
189	R:R:G70	R:R:M73	3.49	No	No	0	4	4
190	R:R:A104	R:R:S68	3.42	No	No	0	7	8
191	R:R:A357	R:R:S219	3.42	No	No	0	6	6
192	R:R:I75	R:R:P387	3.39	Yes	No	0	9	9
193	R:R:I229	R:R:P230	3.39	No	No	0	6	9
194	R:R:D359	R:R:G362	3.35	No	No	0	4	4
195	R:R:C384	R:R:I64	3.27	No	No	0	5	7
196	R:R:N72	R:R:P387	3.26	Yes	No	0	9	9
197	R:R:A97	R:R:I75	3.25	No	Yes	0	9	9
198	R:R:A155	R:R:I156	3.25	No	No	0	8	8
199	R:R:C384	R:R:M67	3.24	No	No	0	5	4
200	L:L:M3	R:R:S368	3.07	No	No	0	0	5
201	R:R:F392	R:R:G71	3.01	Yes	No	0	6	8
202	R:R:F343	R:R:G231	3.01	No	No	0	6	6
203	R:R:L96	R:R:S141	3	No	No	0	9	9
204	R:R:L102	R:R:S137	3	No	No	0	7	7
205	R:R:L74	R:R:V78	2.98	No	Yes	0	7	8
206	R:R:L81	R:R:V77	2.98	No	No	0	5	4
207	R:R:L79	R:R:V78	2.98	No	Yes	0	8	8
208	R:R:L150	R:R:V146	2.98	No	No	0	6	8
209	R:R:L240	R:R:V236	2.98	No	No	0	6	5
210	R:R:L335	R:R:V331	2.98	No	No	0	8	8
211	R:R:L341	R:R:V337	2.98	No	No	0	6	7
212	R:R:L203	R:R:T119	2.95	No	No	0	3	4
213	L:L:?2	L:L:D1	2.92	Yes	No	0	0	0
214	R:R:G183	R:R:Y132	2.9	No	No	0	5	6
215	R:R:Q204	R:R:V206	2.87	No	No	0	4	4
216	R:R:K328	R:R:K329	2.87	No	No	0	8	6
217	R:R:I76	R:R:L101	2.85	No	No	0	8	8
218	R:R:I241	R:R:L245	2.85	No	No	0	9	8
219	R:R:K324	R:R:L326	2.82	No	No	0	5	5
220	R:R:L79	R:R:L94	2.77	No	No	0	8	7
221	R:R:A91	R:R:R168	2.77	No	No	0	6	4
222	R:R:A363	R:R:R356	2.77	No	No	0	3	4
223	R:R:F358	R:R:V220	2.62	No	No	0	5	5
224	R:R:F122	R:R:I121	2.51	Yes	No	0	6	4
225	R:R:L240	R:R:R243	2.43	No	No	0	6	5
226	R:R:I241	R:R:Y153	2.42	No	Yes	0	9	8
227	R:R:K329	R:R:Y246	2.39	No	No	0	6	6
228	R:R:L221	R:R:W218	2.28	No	Yes	0	4	7
229	R:R:D359	R:R:W355	2.23	No	No	0	4	5
230	R:R:F227	R:R:F228	2.14	Yes	No	0	8	5
231	R:R:G70	R:R:G71	2.11	No	No	0	4	8
232	R:R:G239	R:R:S242	1.86	No	No	0	4	6
233	R:R:G369	R:R:S368	1.86	No	No	0	3	5
234	R:R:G70	R:R:V69	1.84	No	No	0	4	6
235	R:R:A381	R:R:C345	1.81	No	No	0	5	8
236	R:R:A171	R:R:A91	1.79	No	No	0	7	6
237	R:R:P348	R:R:S351	1.78	No	No	0	9	6
238	R:R:G80	R:R:L94	1.71	No	No	0	3	7
239	R:R:G248	R:R:L247	1.71	No	No	0	6	5
240	R:R:A400	R:R:V78	1.7	No	Yes	0	8	8
241	R:R:A171	R:R:V88	1.7	No	No	0	7	6
242	R:R:G369	R:R:N115	1.7	No	No	0	3	5
243	R:R:A235	R:R:V339	1.7	No	No	0	5	8
244	R:R:D359	R:R:G360	1.68	No	No	0	4	1
245	R:R:L113	R:R:P109	1.64	No	No	0	5	8
246	R:R:L113	R:R:P114	1.64	No	No	0	5	5
247	R:R:L378	R:R:P348	1.64	No	No	0	7	9
248	R:R:S144	R:R:S95	1.63	No	No	0	8	9
249	R:R:S211	R:R:V214	1.62	No	No	0	5	4
250	R:R:V77	R:R:V78	1.6	No	Yes	0	4	8
251	R:R:S144	R:R:T178	1.6	No	No	0	8	7
252	R:R:V232	R:R:V236	1.6	No	No	0	4	5
253	R:R:V385	R:R:V389	1.6	No	Yes	0	7	8
254	R:R:P197	R:R:Q196	1.58	No	No	0	1	3
255	R:R:M67	R:R:V63	1.52	No	No	0	4	5
256	R:R:M334	R:R:V389	1.52	No	Yes	0	8	8
257	R:R:L101	R:R:V105	1.49	No	No	0	8	5
258	R:R:N353	R:R:S219	1.49	No	No	0	7	6
259	R:R:L224	R:R:V220	1.49	No	No	0	4	5
260	R:R:L245	R:R:V331	1.49	No	No	0	8	8
261	R:R:I121	R:R:M117	1.46	No	No	0	4	5
262	R:R:P159	R:R:R158	1.44	No	No	0	9	6
263	R:R:I56	R:R:L60	1.43	No	No	0	4	6
264	R:R:K328	R:R:L245	1.41	No	No	0	8	8
265	R:R:A400	R:R:F397	1.39	No	No	0	8	8
266	R:R:L344	R:R:L378	1.38	No	No	0	5	7
267	R:R:A237	R:R:Y153	1.33	No	Yes	0	6	8
268	R:R:E244	R:R:L247	1.33	No	No	0	6	5
269	R:R:L402	R:R:Q399	1.33	No	Yes	0	4	6
270	R:R:R158	R:R:S154	1.32	No	No	0	6	5
271	R:R:F397	R:R:R398	1.07	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R57	6.634	5	3	5
2	R:R:Y61	8.7975	4	3	7
3	R:R:N72	7.015	4	0	9
4	R:R:I75	6.2175	4	0	9
5	R:R:V78	2.315	4	0	8
6	R:R:L85	6.5025	4	2	8
7	R:R:F92	4.87667	6	0	8
8	R:R:F120	9.305	4	6	8
9	R:R:F122	7.825	4	0	6
10	R:R:Y153	4.4175	4	0	8
11	R:R:W165	6.46	4	0	5
12	R:R:Q166	6.1175	4	0	7
13	R:R:Y189	6.45	6	1	7
14	R:R:H207	6.074	5	1	5
15	R:R:W209	6.20833	6	1	6
16	R:R:W218	7.814	5	1	7
17	R:R:F227	4.5775	4	0	8
18	R:R:Y238	6.1925	4	0	9
19	R:R:W346	6.28167	6	0	8
20	R:R:I372	6.8025	4	0	4
21	R:R:Y380	5.15	5	0	7
22	R:R:V389	2.88	4	0	8
23	R:R:Y390	4.8	5	4	9
24	R:R:F392	5.8575	4	0	6
25	R:R:Q399	6.004	5	2	6
26	L:L:?2	6.766	5	0	0
27	L:L:W5	8.07	4	0	0
28	L:L:F8	5.9125	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L377	R:R:Y61	18.8915	11.72	No	Yes	0	7	7
2	R:R:I64	R:R:L377	24.4673	4.28	No	No	0	7	7
3	R:R:I64	R:R:M108	33.5929	5.83	No	No	0	7	7
4	R:R:M108	R:R:Y380	37.1845	3.59	No	Yes	0	7	7
5	R:R:C107	R:R:Y380	20.6497	8.06	No	Yes	0	7	7
6	R:R:C107	R:R:M134	21.2483	6.48	No	No	0	7	8
7	L:L:?9	R:R:M134	32.4166	14	No	No	0	0	8
8	L:L:?9	L:L:F8	33.0403	9.04	No	Yes	0	0	0
9	L:L:F8	R:R:Y189	71.6773	4.13	Yes	Yes	0	0	7
10	R:R:S131	R:R:Y189	98.6102	3.82	No	Yes	0	5	7
11	R:R:P190	R:R:S131	100	3.56	No	No	0	6	5
12	R:R:P190	R:R:Y132	99.9749	9.74	No	No	0	6	6
13	R:R:V136	R:R:Y132	99.8995	8.83	No	No	0	6	6
14	R:R:S182	R:R:V136	99.8493	4.85	No	No	0	8	6
15	R:R:S182	R:R:V140	99.7237	4.85	No	No	0	8	8
16	R:R:V140	R:R:W179	98.9577	14.71	No	No	5	8	9
17	R:R:S95	R:R:W179	99.4726	6.18	No	No	0	9	9
18	R:R:I175	R:R:S95	99.0205	6.19	No	No	0	7	9
19	R:R:F92	R:R:I175	98.8865	3.77	Yes	No	0	8	7
20	R:R:F92	R:R:I148	89.3089	3.77	Yes	No	0	8	9
21	R:R:I148	R:R:Y390	69.4922	3.63	No	Yes	4	9	9
22	R:R:L93	R:R:Y390	68.6132	4.69	No	Yes	0	8	9
23	R:R:C391	R:R:L93	67.8932	4.76	No	No	0	7	8
24	R:R:C391	R:R:I75	41.831	8.18	No	Yes	0	7	9
25	R:R:I75	R:R:P387	17.1376	3.39	Yes	No	0	9	9
26	R:R:N72	R:R:P387	16.0534	3.26	Yes	No	0	9	9
27	R:R:S379	R:R:Y380	25.6729	3.82	No	Yes	0	7	7
28	R:R:S379	R:R:W346	26.2296	6.18	No	Yes	0	7	8
29	R:R:V138	R:R:W346	41.9859	6.13	No	Yes	0	7	8
30	L:L:F8	R:R:V138	42.7854	6.55	Yes	No	0	0	7
31	R:R:F392	R:R:I75	26.2213	10.05	Yes	Yes	0	6	9
32	R:R:F392	R:R:R396	24.5259	4.28	Yes	No	0	6	7
33	R:R:C391	R:R:R396	25.451	5.57	No	No	0	7	7
34	R:R:F392	R:R:L74	40.4831	6.09	Yes	No	0	6	7
35	R:R:L74	R:R:V78	38.5533	2.98	No	Yes	0	7	8
36	R:R:L79	R:R:V78	25.945	2.98	No	Yes	0	8	8
37	R:R:L79	R:R:N90	19.5404	5.49	No	No	0	8	9
38	R:R:L85	R:R:N90	13.0688	5.49	Yes	No	0	8	9
39	R:R:E151	R:R:F92	21.1059	8.16	No	Yes	0	9	8
40	R:R:F110	R:R:V130	17.732	13.11	No	No	0	6	6
41	R:R:M134	R:R:V130	18.7157	4.56	No	No	0	8	6
42	R:R:F110	R:R:F122	13.0144	10.72	No	Yes	0	6	6
43	L:L:?2	L:L:M3	15.3083	5.07	Yes	No	0	0	0
44	L:L:M3	R:R:H364	19.1092	9.19	No	No	0	0	1
45	R:R:H364	R:R:R356	20.0594	10.16	No	No	0	1	4
46	L:L:W5	R:R:R356	27.4268	11	Yes	No	0	0	4
47	L:L:W5	R:R:I372	12.0474	11.74	Yes	Yes	0	0	4
48	L:L:W5	R:R:N353	27.272	5.65	Yes	No	0	0	7
49	L:L:D7	R:R:N353	29.1096	5.39	No	No	0	0	7
50	R:R:W218	R:R:Y189	10.9339	7.72	Yes	Yes	1	7	7
51	R:R:I148	R:R:R152	19.4064	5.01	No	No	4	9	9
52	R:R:R152	R:R:Y238	25.9576	6.17	No	Yes	0	9	9
53	R:R:E151	R:R:Q166	11.8799	5.1	No	Yes	0	9	7
54	R:R:I241	R:R:Y153	12.5958	2.42	No	Yes	0	9	8
55	R:R:I241	R:R:L245	13.8097	2.85	No	No	0	9	8
56	R:R:L245	R:R:V331	19.6115	1.49	No	No	0	8	8
57	R:R:L335	R:R:V331	20.6455	2.98	No	No	0	8	8
58	R:R:L335	R:R:Y238	21.6669	8.21	No	Yes	0	8	9
59	R:R:S154	R:R:W165	14.3288	4.94	No	Yes	0	5	5
60	R:R:H170	R:R:W165	14.019	8.46	No	Yes	0	7	5
61	R:R:R158	R:R:S154	10.8711	1.32	No	No	0	6	5
62	L:L:?2	R:R:Q204	11.072	7.64	Yes	No	0	0	4
63	R:R:W346	R:R:Y350	21.5455	5.79	Yes	No	0	8	7
64	R:R:L223	R:R:Y350	19.285	3.52	No	No	0	7	7
65	R:R:F227	R:R:L223	18.1422	3.65	Yes	No	0	8	7
66	L:L:D7	R:R:Y189	27.8999	12.64	No	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C107	R:R:M134	6.48	0	No	No	7	8	2	1
R:R:F120	R:R:P114	8.67	6	Yes	No	8	5	2	1
L:L:?2	R:R:P114	4.71	0	Yes	No	0	5	0	1
R:R:M134	R:R:V130	4.56	0	No	No	8	6	1	2
R:R:S131	R:R:Y189	3.82	0	No	Yes	5	7	2	1
R:R:S131	R:R:T193	6.4	0	No	No	5	6	2	2
L:L:?9	R:R:M134	14	0	No	No	0	8	0	1
R:R:V138	R:R:W346	6.13	0	No	Yes	7	8	1	2
L:L:F8	R:R:V138	6.55	0	Yes	No	0	7	0	1
R:R:H207	R:R:Y189	6.53	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y189	3.86	1	Yes	Yes	6	7	2	1
R:R:W218	R:R:Y189	7.72	1	Yes	Yes	7	7	2	1
L:L:D7	R:R:Y189	12.64	1	No	Yes	0	7	0	1
L:L:F8	R:R:Y189	4.13	0	Yes	Yes	0	7	0	1
R:R:H207	R:R:T193	5.48	1	Yes	No	5	6	1	2
R:R:Q204	R:R:V198	4.3	0	No	No	4	1	1	2
L:L:?2	R:R:Q204	7.64	0	Yes	No	0	4	0	1
R:R:H207	R:R:W209	4.23	1	Yes	Yes	5	6	1	2
L:L:M6	R:R:H207	6.57	0	No	Yes	0	5	0	1
L:L:D7	R:R:H207	7.56	1	No	Yes	0	5	0	1
R:R:W209	R:R:W218	7.5	1	Yes	Yes	6	7	2	2
L:L:F8	R:R:V349	3.93	0	Yes	No	0	7	0	1
L:L:W5	R:R:A352	3.89	0	Yes	No	0	5	0	1
L:L:W5	R:R:N353	5.65	0	Yes	No	0	7	0	1
L:L:D7	R:R:N353	5.39	1	No	No	0	7	0	1
R:R:H364	R:R:R356	10.16	0	No	No	1	4	1	1
L:L:W5	R:R:R356	11	0	Yes	No	0	4	0	1
L:L:M3	R:R:H364	9.19	0	No	No	0	1	0	1
R:R:I372	R:R:L367	4.28	0	Yes	No	4	4	1	2
R:R:I372	R:R:I375	5.89	0	Yes	No	4	6	1	2
R:R:H376	R:R:I372	5.3	0	No	Yes	5	4	2	1
L:L:W5	R:R:I372	11.74	0	Yes	Yes	0	4	0	1
L:L:M3	R:R:S368	3.07	0	No	No	0	5	0	1
R:R:Q204	R:R:V206	2.87	0	No	No	4	4	1	2
R:R:A363	R:R:R356	2.77	0	No	No	3	4	2	1
R:R:G369	R:R:S368	1.86	0	No	No	3	5	2	1
R:R:L113	R:R:P114	1.64	0	No	No	5	5	2	1
R:R:N353	R:R:S219	1.49	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IA7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	256
Number of Links	271
Number of Hubs	28
Number of Links mediated by Hubs	114
Number of Communities	6
Number of Nodes involved in Communities	23
Number of Links involved in Communities	28

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	43817
Length Of Smallest Path	3
Average Path Length	18.1761
Length of Longest Path	37
Minimum Path Strength	1.23
Average Path Strength	5.9104
Maximum Path Strength	12.825
Minimum Path Correlation	0.7
Average Path Correlation	0.919502
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	37.5402
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	27.9079
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • cholecystokinin signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • developmental process • multicellular organismal process • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • multicellular organism development • cell differentiation • anatomical structure development • cell migration • cell motility • system development • behavior • eating behavior • feeding behavior • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • digestion • cellular anatomical structure • extracellular region • axon • cell projection • neuron projection • plasma membrane bounded cell projection • extracellular space • GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • neuropeptide signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • system process • sensory perception • nervous system process • sensory perception of itch • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • cellular response to ketone • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • photoreceptor disc membrane • 1-phosphatidylinositol-3-kinase regulator activity • kinase regulator activity • type B gastrin/cholecystokinin receptor binding • cholecystokinin receptor binding • neuropeptide receptor binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • gastrin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • cholecystokinin receptor activity • digestive system process • acid secretion • gastric acid secretion • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • positive regulation of cytosolic calcium ion concentration • gland development • digestive system development • tube development • digestive tract development • chemical homeostasis • homeostatic process • regulation of pH • monoatomic ion homeostasis • monoatomic cation homeostasis • pH reduction
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32239
Sequence	>8IA7_nogp_Chain_R E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S R R L R T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G T F I F G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R P L Q A R V W Q T R S H A A R V I V A T W L L S G L L M V P Y P V Y T V V Q P V G P R V L Q C V H R W P S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G P G A H R A L S G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R F R Q A C L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Cholecystokinin-8
UniProt	P06307
Sequence	>8IA7_nogp_Chain_L D ?M G W M D F ? Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F8V	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	Gi2/β1/γ2	3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8V (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.3	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	chim(NtGsL-Gq)/β1/γ2	3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7F8W (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.1	2021-10-13	doi.org/10.1038/s41589-021-00866-8
	7XOW	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Sulfated Gastrin-(10-17)	-	chim(NtGi1-Gq)/β1/γ2	3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	7XOW (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Sulfated Gastrin-(10-17)	-		3.1	2022-07-20	doi.org/10.1038/s41421-022-00420-3
	8IA7	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gq)/β1/γ2	3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3
	8IA7 (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-		3.1	2023-12-06	doi.org/10.1038/s41421-022-00420-3

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.