psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L54	R:R:R57	6.07	No	Yes	0	5	5
2	R:R:R57	R:R:Y61	4.12	Yes	Yes	3	5	7
3	R:R:L116	R:R:R57	3.64	No	Yes	0	5	5
4	R:R:R57	R:R:S373	11.86	Yes	No	3	5	5
5	R:R:F374	R:R:R57	7.48	No	Yes	0	5	5
6	R:R:I58	R:R:L116	4.28	No	No	0	6	5
7	R:R:L377	R:R:L60	5.54	No	No	0	7	6
8	R:R:L112	R:R:Y61	11.72	No	Yes	0	6	7
9	R:R:S373	R:R:Y61	7.63	No	Yes	3	5	7
10	R:R:L377	R:R:Y61	11.72	No	Yes	0	7	7
11	R:R:I64	R:R:M108	5.83	No	No	0	7	7
12	R:R:I64	R:R:L377	4.28	No	No	0	7	7
13	R:R:F65	R:R:M108	3.73	No	No	0	7	7
14	R:R:L66	R:R:M67	4.24	No	No	0	5	4
15	R:R:N72	R:R:S68	4.47	Yes	No	0	9	8
16	R:R:D100	R:R:N72	13.46	No	Yes	0	9	9
17	R:R:L101	R:R:N72	6.87	No	Yes	0	8	9
18	R:R:F392	R:R:L74	6.09	Yes	No	0	6	7
19	R:R:C391	R:R:I75	8.18	No	Yes	0	7	9
20	R:R:F392	R:R:I75	10.05	Yes	Yes	0	6	9
21	R:R:I76	R:R:V98	4.61	No	No	0	8	7
22	R:R:L79	R:R:N90	5.49	No	No	0	8	9
23	R:R:R84	R:R:S82	5.27	No	No	2	5	6
24	R:R:L85	R:R:S82	9.01	Yes	No	2	8	6
25	R:R:Q399	R:R:S82	8.66	Yes	No	2	6	6
26	R:R:R83	R:R:R86	4.26	No	No	0	7	8
27	R:R:L85	R:R:R84	4.86	Yes	No	2	8	5
28	R:R:Q399	R:R:R84	7.01	Yes	No	2	6	5
29	R:R:L85	R:R:N90	5.49	Yes	No	0	8	9
30	R:R:L85	R:R:Q399	6.65	Yes	Yes	2	8	6
31	R:R:R168	R:R:R86	7.46	No	No	0	4	8
32	R:R:T87	R:R:T89	4.71	No	No	0	7	8
33	R:R:N90	R:R:T87	10.24	No	No	0	9	7
34	R:R:A147	R:R:F92	4.16	No	Yes	0	7	8
35	R:R:F92	R:R:I148	3.77	Yes	No	0	8	9
36	R:R:E151	R:R:F92	8.16	No	Yes	0	9	8
37	R:R:A171	R:R:F92	4.16	No	Yes	0	7	8
38	R:R:F92	R:R:V174	5.24	Yes	No	0	8	6
39	R:R:F92	R:R:I175	3.77	Yes	No	0	8	7
40	R:R:L93	R:R:Y390	4.69	No	Yes	0	8	9
41	R:R:C391	R:R:L93	4.76	No	No	0	7	8
42	R:R:I175	R:R:S95	6.19	No	No	0	7	9
43	R:R:S95	R:R:W179	6.18	No	No	0	9	9
44	R:R:L96	R:R:N386	6.87	No	No	0	9	9
45	R:R:S99	R:R:V140	4.85	No	No	5	9	8
46	R:R:S99	R:R:W179	3.71	No	No	5	9	9
47	R:R:D100	R:R:L103	4.07	No	No	0	9	7
48	R:R:A383	R:R:D100	4.63	No	No	0	9	9
49	R:R:L102	R:R:L133	5.54	No	No	0	7	5
50	R:R:L103	R:R:S137	7.51	No	No	0	7	7
51	R:R:A106	R:R:L133	4.73	No	No	0	5	5
52	R:R:C107	R:R:M134	6.48	No	No	0	7	8
53	R:R:C107	R:R:Y380	8.06	No	Yes	0	7	7
54	R:R:M108	R:R:Y380	3.59	No	Yes	0	7	7
55	R:R:F110	R:R:P109	7.22	No	No	0	6	8
56	R:R:F110	R:R:F122	10.72	No	Yes	0	6	6
57	R:R:F110	R:R:V130	13.11	No	No	0	6	6
58	R:R:T111	R:R:Y380	3.75	No	Yes	0	7	7
59	R:R:L112	R:R:L116	5.54	No	No	0	6	5
60	R:R:F120	R:R:P114	8.67	Yes	No	0	8	5
61	L:L:?2	R:R:P114	4.71	Yes	No	0	0	5
62	R:R:F120	R:R:F122	11.79	Yes	Yes	0	8	6
63	R:R:C127	R:R:F120	8.38	No	Yes	6	9	8
64	R:R:C205	R:R:F120	8.38	No	Yes	6	9	8
65	R:R:F122	R:R:I126	6.28	Yes	No	0	6	5
66	R:R:K128	R:R:T124	4.5	No	No	0	7	4
67	R:R:T124	R:R:V195	6.35	No	No	0	4	4
68	R:R:C127	R:R:C205	7.28	No	No	6	9	9
69	R:R:M134	R:R:V130	4.56	No	No	0	8	6
70	R:R:S131	R:R:Y189	3.82	No	Yes	0	5	7
71	R:R:P190	R:R:S131	3.56	No	No	0	6	5
72	R:R:S131	R:R:T193	6.4	No	No	0	5	6
73	R:R:V136	R:R:Y132	8.83	No	No	0	6	6
74	R:R:P190	R:R:Y132	9.74	No	No	0	6	6
75	L:L:?9	R:R:M134	14	No	No	0	0	8
76	R:R:G135	R:R:M186	6.99	No	No	0	6	8
77	R:R:S182	R:R:V136	4.85	No	No	0	8	6
78	R:R:V138	R:R:W346	6.13	No	Yes	0	7	8
79	L:L:F8	R:R:V138	6.55	Yes	No	0	0	7
80	R:R:S139	R:R:S182	6.52	No	No	0	8	8
81	R:R:V140	R:R:W179	14.71	No	No	5	8	9
82	R:R:S182	R:R:V140	4.85	No	No	0	8	8
83	R:R:P230	R:R:T142	3.5	No	No	0	9	8
84	R:R:F342	R:R:T142	3.89	No	No	0	9	8
85	R:R:L143	R:R:T178	4.42	No	No	0	6	7
86	R:R:L145	R:R:N386	4.12	No	No	0	9	9
87	R:R:L145	R:R:Y390	4.69	No	Yes	0	9	9
88	R:R:P230	R:R:V146	3.53	No	No	0	9	8
89	R:R:I148	R:R:R152	5.01	No	No	4	9	9
90	R:R:I148	R:R:Y390	3.63	No	Yes	4	9	9
91	R:R:A149	R:R:Y238	5.34	No	Yes	0	9	9
92	R:R:L150	R:R:V233	4.47	No	No	0	6	6
93	R:R:E151	R:R:Q166	5.1	No	Yes	0	9	7
94	R:R:E151	R:R:H170	8.62	No	No	0	9	7
95	R:R:R152	R:R:Y238	6.17	No	Yes	0	9	9
96	R:R:R152	R:R:Y390	7.2	No	Yes	4	9	9
97	R:R:C157	R:R:Y153	8.06	No	Yes	0	7	8
98	R:R:L240	R:R:Y153	5.86	No	Yes	0	6	8
99	R:R:S154	R:R:W165	4.94	No	Yes	0	5	5
100	R:R:A155	R:R:Q166	4.55	No	Yes	0	8	7
101	R:R:C157	R:R:E244	9.12	No	No	0	7	6
102	R:R:Q161	R:R:R158	7.01	No	No	0	5	6
103	R:R:A162	R:R:Q166	6.06	No	Yes	0	7	7
104	R:R:V164	R:R:W165	3.68	No	Yes	0	4	5
105	R:R:Q166	R:R:W165	8.76	Yes	Yes	0	7	5
106	R:R:H170	R:R:W165	8.46	No	Yes	0	7	5
107	R:R:H170	R:R:V174	5.54	No	No	0	7	6
108	R:R:R173	R:R:V176	3.92	No	No	0	4	4
109	R:R:L185	R:R:M186	4.24	No	No	0	6	8
110	R:R:L222	R:R:M186	4.24	No	No	0	7	8
111	R:R:P188	R:R:V187	5.3	No	No	0	9	4
112	R:R:P188	R:R:W218	6.76	No	Yes	0	9	7
113	R:R:H207	R:R:Y189	6.53	Yes	Yes	1	5	7
114	R:R:W209	R:R:Y189	3.86	Yes	Yes	1	6	7
115	R:R:W218	R:R:Y189	7.72	Yes	Yes	1	7	7
116	L:L:D7	R:R:Y189	12.64	No	Yes	1	0	7
117	L:L:F8	R:R:Y189	4.13	Yes	Yes	0	0	7
118	R:R:V191	R:R:Y192	7.57	No	No	0	4	4
119	R:R:W209	R:R:Y192	10.61	Yes	No	1	6	4
120	R:R:P210	R:R:Y192	18.08	No	No	1	4	4
121	R:R:H207	R:R:T193	5.48	Yes	No	0	5	6
122	R:R:R208	R:R:V194	11.77	No	No	0	2	4
123	R:R:C205	R:R:V195	6.83	No	No	0	9	4
124	R:R:Q196	R:R:V206	4.3	No	No	0	3	4
125	R:R:Q196	R:R:R208	4.67	No	No	0	3	2
126	R:R:L203	R:R:P197	4.93	No	No	0	3	1
127	R:R:Q204	R:R:V198	4.3	No	No	0	4	1
128	R:R:G199	R:R:P200	4.06	No	No	0	1	3
129	R:R:P200	R:R:R201	4.32	No	No	0	3	1
130	L:L:?2	R:R:Q204	7.64	Yes	No	0	0	4
131	R:R:H207	R:R:W209	4.23	Yes	Yes	1	5	6
132	L:L:M6	R:R:H207	6.57	No	Yes	0	0	5
133	L:L:D7	R:R:H207	7.56	No	Yes	1	0	5
134	R:R:P210	R:R:W209	4.05	No	Yes	1	4	6
135	R:R:R215	R:R:W209	7	No	Yes	0	5	6
136	R:R:W209	R:R:W218	7.5	Yes	Yes	1	6	7
137	R:R:P210	R:R:V214	5.3	No	No	0	4	4
138	R:R:Q216	R:R:R213	5.84	No	No	0	4	5
139	R:R:F358	R:R:Q216	5.86	No	No	0	5	4
140	R:R:L222	R:R:W218	14.81	No	Yes	0	7	7
141	R:R:L221	R:R:L225	4.15	No	No	0	4	5
142	R:R:F227	R:R:L223	3.65	Yes	No	0	8	7
143	R:R:L223	R:R:Y350	3.52	No	No	0	7	7
144	R:R:F228	R:R:L224	3.65	No	No	0	5	4
145	R:R:L226	R:R:Y350	5.86	No	No	0	8	7
146	R:R:F227	R:R:F343	6.43	Yes	No	0	8	6
147	R:R:F227	R:R:L347	6.09	Yes	No	0	8	7
148	R:R:F342	R:R:M234	3.73	No	No	0	9	8
149	R:R:L335	R:R:Y238	8.21	No	Yes	0	8	9
150	R:R:V339	R:R:Y238	5.05	No	Yes	0	8	9
151	R:R:S242	R:R:V332	8.08	No	No	0	6	7
152	R:R:K329	R:R:L325	4.23	No	No	0	6	4
153	R:R:H394	R:R:M334	6.57	No	No	0	8	8
154	R:R:I338	R:R:V389	4.61	No	Yes	0	8	8
155	R:R:L341	R:R:V385	4.47	No	No	0	6	7
156	R:R:F342	R:R:W346	7.02	No	Yes	0	9	8
157	R:R:C345	R:R:W346	3.92	No	Yes	0	8	8
158	R:R:W346	R:R:Y350	5.79	Yes	No	0	8	7
159	R:R:S379	R:R:W346	6.18	No	Yes	0	7	8
160	R:R:S382	R:R:W346	8.65	No	Yes	0	9	8
161	R:R:L347	R:R:P348	4.93	No	No	0	7	9
162	L:L:F8	R:R:V349	3.93	Yes	No	0	0	7
163	L:L:W5	R:R:A352	3.89	Yes	No	0	0	5
164	L:L:W5	R:R:N353	5.65	Yes	No	0	0	7
165	L:L:D7	R:R:N353	5.39	No	No	0	0	7
166	R:R:F358	R:R:T354	3.89	No	No	0	5	6
167	R:R:A363	R:R:W355	9.08	No	No	0	3	5
168	R:R:A366	R:R:W355	3.89	No	No	0	4	5
169	R:R:H364	R:R:R356	10.16	No	No	0	1	4
170	L:L:W5	R:R:R356	11	Yes	No	0	0	4
171	R:R:G360	R:R:P361	4.06	No	No	0	1	1
172	L:L:M3	R:R:H364	9.19	No	No	0	0	1
173	R:R:L367	R:R:P371	8.21	No	No	0	4	5
174	R:R:I372	R:R:L367	4.28	Yes	No	0	4	4
175	R:R:A370	R:R:P371	3.74	No	No	0	3	5
176	R:R:I372	R:R:I375	5.89	Yes	No	0	4	6
177	R:R:H376	R:R:I372	5.3	No	Yes	0	5	4
178	L:L:W5	R:R:I372	11.74	Yes	Yes	0	0	4
179	R:R:H376	R:R:Y380	6.53	No	Yes	0	5	7
180	R:R:S379	R:R:Y380	3.82	No	Yes	0	7	7
181	R:R:V389	R:R:Y390	3.79	Yes	Yes	0	8	9
182	R:R:C391	R:R:R396	5.57	No	No	0	7	7
183	R:R:F392	R:R:R396	4.28	Yes	No	0	6	7
184	R:R:H394	R:R:M393	9.19	No	No	0	8	7
185	R:R:E403	R:R:Q399	6.37	No	Yes	0	5	6
186	L:L:?2	L:L:M3	5.07	Yes	No	0	0	0
187	L:L:?2	L:L:G4	13.49	Yes	No	0	0	0
188	L:L:?9	L:L:F8	9.04	No	Yes	0	0	0
189	R:R:G70	R:R:M73	3.49	No	No	0	4	4
190	R:R:A104	R:R:S68	3.42	No	No	0	7	8
191	R:R:A357	R:R:S219	3.42	No	No	0	6	6
192	R:R:I75	R:R:P387	3.39	Yes	No	0	9	9
193	R:R:I229	R:R:P230	3.39	No	No	0	6	9
194	R:R:D359	R:R:G362	3.35	No	No	0	4	4
195	R:R:C384	R:R:I64	3.27	No	No	0	5	7
196	R:R:N72	R:R:P387	3.26	Yes	No	0	9	9
197	R:R:A97	R:R:I75	3.25	No	Yes	0	9	9
198	R:R:A155	R:R:I156	3.25	No	No	0	8	8
199	R:R:C384	R:R:M67	3.24	No	No	0	5	4
200	L:L:M3	R:R:S368	3.07	No	No	0	0	5
201	R:R:F392	R:R:G71	3.01	Yes	No	0	6	8
202	R:R:F343	R:R:G231	3.01	No	No	0	6	6
203	R:R:L96	R:R:S141	3	No	No	0	9	9
204	R:R:L102	R:R:S137	3	No	No	0	7	7
205	R:R:L74	R:R:V78	2.98	No	Yes	0	7	8
206	R:R:L81	R:R:V77	2.98	No	No	0	5	4
207	R:R:L79	R:R:V78	2.98	No	Yes	0	8	8
208	R:R:L150	R:R:V146	2.98	No	No	0	6	8
209	R:R:L240	R:R:V236	2.98	No	No	0	6	5
210	R:R:L335	R:R:V331	2.98	No	No	0	8	8
211	R:R:L341	R:R:V337	2.98	No	No	0	6	7
212	R:R:L203	R:R:T119	2.95	No	No	0	3	4
213	L:L:?2	L:L:D1	2.92	Yes	No	0	0	0
214	R:R:G183	R:R:Y132	2.9	No	No	0	5	6
215	R:R:Q204	R:R:V206	2.87	No	No	0	4	4
216	R:R:K328	R:R:K329	2.87	No	No	0	8	6
217	R:R:I76	R:R:L101	2.85	No	No	0	8	8
218	R:R:I241	R:R:L245	2.85	No	No	0	9	8
219	R:R:K324	R:R:L326	2.82	No	No	0	5	5
220	R:R:L79	R:R:L94	2.77	No	No	0	8	7
221	R:R:A91	R:R:R168	2.77	No	No	0	6	4
222	R:R:A363	R:R:R356	2.77	No	No	0	3	4
223	R:R:F358	R:R:V220	2.62	No	No	0	5	5
224	R:R:F122	R:R:I121	2.51	Yes	No	0	6	4
225	R:R:L240	R:R:R243	2.43	No	No	0	6	5
226	R:R:I241	R:R:Y153	2.42	No	Yes	0	9	8
227	R:R:K329	R:R:Y246	2.39	No	No	0	6	6
228	R:R:L221	R:R:W218	2.28	No	Yes	0	4	7
229	R:R:D359	R:R:W355	2.23	No	No	0	4	5
230	R:R:F227	R:R:F228	2.14	Yes	No	0	8	5
231	R:R:G70	R:R:G71	2.11	No	No	0	4	8
232	R:R:G239	R:R:S242	1.86	No	No	0	4	6
233	R:R:G369	R:R:S368	1.86	No	No	0	3	5
234	R:R:G70	R:R:V69	1.84	No	No	0	4	6
235	R:R:A381	R:R:C345	1.81	No	No	0	5	8
236	R:R:A171	R:R:A91	1.79	No	No	0	7	6
237	R:R:P348	R:R:S351	1.78	No	No	0	9	6
238	R:R:G80	R:R:L94	1.71	No	No	0	3	7
239	R:R:G248	R:R:L247	1.71	No	No	0	6	5
240	R:R:A400	R:R:V78	1.7	No	Yes	0	8	8
241	R:R:A171	R:R:V88	1.7	No	No	0	7	6
242	R:R:G369	R:R:N115	1.7	No	No	0	3	5
243	R:R:A235	R:R:V339	1.7	No	No	0	5	8
244	R:R:D359	R:R:G360	1.68	No	No	0	4	1
245	R:R:L113	R:R:P109	1.64	No	No	0	5	8
246	R:R:L113	R:R:P114	1.64	No	No	0	5	5
247	R:R:L378	R:R:P348	1.64	No	No	0	7	9
248	R:R:S144	R:R:S95	1.63	No	No	0	8	9
249	R:R:S211	R:R:V214	1.62	No	No	0	5	4
250	R:R:V77	R:R:V78	1.6	No	Yes	0	4	8
251	R:R:S144	R:R:T178	1.6	No	No	0	8	7
252	R:R:V232	R:R:V236	1.6	No	No	0	4	5
253	R:R:V385	R:R:V389	1.6	No	Yes	0	7	8
254	R:R:P197	R:R:Q196	1.58	No	No	0	1	3
255	R:R:M67	R:R:V63	1.52	No	No	0	4	5
256	R:R:M334	R:R:V389	1.52	No	Yes	0	8	8
257	R:R:L101	R:R:V105	1.49	No	No	0	8	5
258	R:R:N353	R:R:S219	1.49	No	No	0	7	6
259	R:R:L224	R:R:V220	1.49	No	No	0	4	5
260	R:R:L245	R:R:V331	1.49	No	No	0	8	8
261	R:R:I121	R:R:M117	1.46	No	No	0	4	5
262	R:R:P159	R:R:R158	1.44	No	No	0	9	6
263	R:R:I56	R:R:L60	1.43	No	No	0	4	6
264	R:R:K328	R:R:L245	1.41	No	No	0	8	8
265	R:R:A400	R:R:F397	1.39	No	No	0	8	8
266	R:R:L344	R:R:L378	1.38	No	No	0	5	7
267	R:R:A237	R:R:Y153	1.33	No	Yes	0	6	8
268	R:R:E244	R:R:L247	1.33	No	No	0	6	5
269	R:R:L402	R:R:Q399	1.33	No	Yes	0	4	6
270	R:R:R158	R:R:S154	1.32	No	No	0	6	5
271	R:R:F397	R:R:R398	1.07	No	No	0	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:R57	6.634	5	3	5
2	R:R:Y61	8.7975	4	3	7
3	R:R:N72	7.015	4	0	9
4	R:R:I75	6.2175	4	0	9
5	R:R:V78	2.315	4	0	8
6	R:R:L85	6.5025	4	2	8
7	R:R:F92	4.87667	6	0	8
8	R:R:F120	9.305	4	6	8
9	R:R:F122	7.825	4	0	6
10	R:R:Y153	4.4175	4	0	8
11	R:R:W165	6.46	4	0	5
12	R:R:Q166	6.1175	4	0	7
13	R:R:Y189	6.45	6	1	7
14	R:R:H207	6.074	5	1	5
15	R:R:W209	6.20833	6	1	6
16	R:R:W218	7.814	5	1	7
17	R:R:F227	4.5775	4	0	8
18	R:R:Y238	6.1925	4	0	9
19	R:R:W346	6.28167	6	0	8
20	R:R:I372	6.8025	4	0	4
21	R:R:Y380	5.15	5	0	7
22	R:R:V389	2.88	4	0	8
23	R:R:Y390	4.8	5	4	9
24	R:R:F392	5.8575	4	0	6
25	R:R:Q399	6.004	5	2	6
26	L:L:?2	6.766	5	0	0
27	L:L:W5	8.07	4	0	0
28	L:L:F8	5.9125	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L377	R:R:Y61	18.8915	11.72	No	Yes	0	7	7
2	R:R:I64	R:R:L377	24.4673	4.28	No	No	0	7	7
3	R:R:I64	R:R:M108	33.5929	5.83	No	No	0	7	7
4	R:R:M108	R:R:Y380	37.1845	3.59	No	Yes	0	7	7
5	R:R:C107	R:R:Y380	20.6497	8.06	No	Yes	0	7	7
6	R:R:C107	R:R:M134	21.2483	6.48	No	No	0	7	8
7	L:L:?9	R:R:M134	32.4166	14	No	No	0	0	8
8	L:L:?9	L:L:F8	33.0403	9.04	No	Yes	0	0	0
9	L:L:F8	R:R:Y189	71.6773	4.13	Yes	Yes	0	0	7
10	R:R:S131	R:R:Y189	98.6102	3.82	No	Yes	0	5	7
11	R:R:P190	R:R:S131	100	3.56	No	No	0	6	5
12	R:R:P190	R:R:Y132	99.9749	9.74	No	No	0	6	6
13	R:R:V136	R:R:Y132	99.8995	8.83	No	No	0	6	6
14	R:R:S182	R:R:V136	99.8493	4.85	No	No	0	8	6
15	R:R:S182	R:R:V140	99.7237	4.85	No	No	0	8	8
16	R:R:V140	R:R:W179	98.9577	14.71	No	No	5	8	9
17	R:R:S95	R:R:W179	99.4726	6.18	No	No	0	9	9
18	R:R:I175	R:R:S95	99.0205	6.19	No	No	0	7	9
19	R:R:F92	R:R:I175	98.8865	3.77	Yes	No	0	8	7
20	R:R:F92	R:R:I148	89.3089	3.77	Yes	No	0	8	9
21	R:R:I148	R:R:Y390	69.4922	3.63	No	Yes	4	9	9
22	R:R:L93	R:R:Y390	68.6132	4.69	No	Yes	0	8	9
23	R:R:C391	R:R:L93	67.8932	4.76	No	No	0	7	8
24	R:R:C391	R:R:I75	41.831	8.18	No	Yes	0	7	9
25	R:R:I75	R:R:P387	17.1376	3.39	Yes	No	0	9	9
26	R:R:N72	R:R:P387	16.0534	3.26	Yes	No	0	9	9
27	R:R:S379	R:R:Y380	25.6729	3.82	No	Yes	0	7	7
28	R:R:S379	R:R:W346	26.2296	6.18	No	Yes	0	7	8
29	R:R:V138	R:R:W346	41.9859	6.13	No	Yes	0	7	8
30	L:L:F8	R:R:V138	42.7854	6.55	Yes	No	0	0	7
31	R:R:F392	R:R:I75	26.2213	10.05	Yes	Yes	0	6	9
32	R:R:F392	R:R:R396	24.5259	4.28	Yes	No	0	6	7
33	R:R:C391	R:R:R396	25.451	5.57	No	No	0	7	7
34	R:R:F392	R:R:L74	40.4831	6.09	Yes	No	0	6	7
35	R:R:L74	R:R:V78	38.5533	2.98	No	Yes	0	7	8
36	R:R:L79	R:R:V78	25.945	2.98	No	Yes	0	8	8
37	R:R:L79	R:R:N90	19.5404	5.49	No	No	0	8	9
38	R:R:L85	R:R:N90	13.0688	5.49	Yes	No	0	8	9
39	R:R:E151	R:R:F92	21.1059	8.16	No	Yes	0	9	8
40	R:R:F110	R:R:V130	17.732	13.11	No	No	0	6	6
41	R:R:M134	R:R:V130	18.7157	4.56	No	No	0	8	6
42	R:R:F110	R:R:F122	13.0144	10.72	No	Yes	0	6	6
43	L:L:?2	L:L:M3	15.3083	5.07	Yes	No	0	0	0
44	L:L:M3	R:R:H364	19.1092	9.19	No	No	0	0	1
45	R:R:H364	R:R:R356	20.0594	10.16	No	No	0	1	4
46	L:L:W5	R:R:R356	27.4268	11	Yes	No	0	0	4
47	L:L:W5	R:R:I372	12.0474	11.74	Yes	Yes	0	0	4
48	L:L:W5	R:R:N353	27.272	5.65	Yes	No	0	0	7
49	L:L:D7	R:R:N353	29.1096	5.39	No	No	0	0	7
50	R:R:W218	R:R:Y189	10.9339	7.72	Yes	Yes	1	7	7
51	R:R:I148	R:R:R152	19.4064	5.01	No	No	4	9	9
52	R:R:R152	R:R:Y238	25.9576	6.17	No	Yes	0	9	9
53	R:R:E151	R:R:Q166	11.8799	5.1	No	Yes	0	9	7
54	R:R:I241	R:R:Y153	12.5958	2.42	No	Yes	0	9	8
55	R:R:I241	R:R:L245	13.8097	2.85	No	No	0	9	8
56	R:R:L245	R:R:V331	19.6115	1.49	No	No	0	8	8
57	R:R:L335	R:R:V331	20.6455	2.98	No	No	0	8	8
58	R:R:L335	R:R:Y238	21.6669	8.21	No	Yes	0	8	9
59	R:R:S154	R:R:W165	14.3288	4.94	No	Yes	0	5	5
60	R:R:H170	R:R:W165	14.019	8.46	No	Yes	0	7	5
61	R:R:R158	R:R:S154	10.8711	1.32	No	No	0	6	5
62	L:L:?2	R:R:Q204	11.072	7.64	Yes	No	0	0	4
63	R:R:W346	R:R:Y350	21.5455	5.79	Yes	No	0	8	7
64	R:R:L223	R:R:Y350	19.285	3.52	No	No	0	7	7
65	R:R:F227	R:R:L223	18.1422	3.65	Yes	No	0	8	7
66	L:L:D7	R:R:Y189	27.8999	12.64	No	Yes	1	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C107	R:R:M134	6.48	0	No	No	7	8	2	1
R:R:F120	R:R:P114	8.67	6	Yes	No	8	5	2	1
L:L:?2	R:R:P114	4.71	0	Yes	No	0	5	0	1
R:R:M134	R:R:V130	4.56	0	No	No	8	6	1	2
R:R:S131	R:R:Y189	3.82	0	No	Yes	5	7	2	1
R:R:S131	R:R:T193	6.4	0	No	No	5	6	2	2
L:L:?9	R:R:M134	14	0	No	No	0	8	0	1
R:R:V138	R:R:W346	6.13	0	No	Yes	7	8	1	2
L:L:F8	R:R:V138	6.55	0	Yes	No	0	7	0	1
R:R:H207	R:R:Y189	6.53	1	Yes	Yes	5	7	1	1
R:R:W209	R:R:Y189	3.86	1	Yes	Yes	6	7	2	1
R:R:W218	R:R:Y189	7.72	1	Yes	Yes	7	7	2	1
L:L:D7	R:R:Y189	12.64	1	No	Yes	0	7	0	1
L:L:F8	R:R:Y189	4.13	0	Yes	Yes	0	7	0	1
R:R:H207	R:R:T193	5.48	1	Yes	No	5	6	1	2
R:R:Q204	R:R:V198	4.3	0	No	No	4	1	1	2
L:L:?2	R:R:Q204	7.64	0	Yes	No	0	4	0	1
R:R:H207	R:R:W209	4.23	1	Yes	Yes	5	6	1	2
L:L:M6	R:R:H207	6.57	0	No	Yes	0	5	0	1
L:L:D7	R:R:H207	7.56	1	No	Yes	0	5	0	1
R:R:W209	R:R:W218	7.5	1	Yes	Yes	6	7	2	2
L:L:F8	R:R:V349	3.93	0	Yes	No	0	7	0	1
L:L:W5	R:R:A352	3.89	0	Yes	No	0	5	0	1
L:L:W5	R:R:N353	5.65	0	Yes	No	0	7	0	1
L:L:D7	R:R:N353	5.39	1	No	No	0	7	0	1
R:R:H364	R:R:R356	10.16	0	No	No	1	4	1	1
L:L:W5	R:R:R356	11	0	Yes	No	0	4	0	1
L:L:M3	R:R:H364	9.19	0	No	No	0	1	0	1
R:R:I372	R:R:L367	4.28	0	Yes	No	4	4	1	2
R:R:I372	R:R:I375	5.89	0	Yes	No	4	6	1	2
R:R:H376	R:R:I372	5.3	0	No	Yes	5	4	2	1
L:L:W5	R:R:I372	11.74	0	Yes	Yes	0	4	0	1
L:L:M3	R:R:S368	3.07	0	No	No	0	5	0	1
R:R:Q204	R:R:V206	2.87	0	No	No	4	4	1	2
R:R:A363	R:R:R356	2.77	0	No	No	3	4	2	1
R:R:G369	R:R:S368	1.86	0	No	No	3	5	2	1
R:R:L113	R:R:P114	1.64	0	No	No	5	5	2	1
R:R:N353	R:R:S219	1.49	0	No	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IA7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.5
Number of Linked Nodes	256
Number of Links	271
Number of Hubs	28
Number of Links mediated by Hubs	114
Number of Communities	6
Number of Nodes involved in Communities	23
Number of Links involved in Communities	28

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	43817
Length Of Smallest Path	3
Average Path Length	18.1761
Length of Longest Path	37
Minimum Path Strength	1.23
Average Path Strength	5.9104
Maximum Path Strength	12.825
Minimum Path Correlation	0.7
Average Path Correlation	0.919501
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	37.5402
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	27.9079
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• enzyme regulator activity • phosphatidylinositol kinase activity • kinase activity • transferase activity • 1-phosphatidylinositol-3-kinase regulator activity • phosphotransferase activity, alcohol group as acceptor • transferase activity, transferring phosphorus-containing groups • lipid kinase activity • molecular function regulator activity • catalytic activity • kinase regulator activity • 1-phosphatidylinositol-3-kinase activity • protein binding • binding • signaling receptor binding • type B gastrin/cholecystokinin receptor binding • G protein-coupled receptor binding • cholecystokinin receptor binding • neuropeptide receptor binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • gastrin receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • cholecystokinin receptor activity • localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus
Gene Ontology	Biological Process	• localization • multicellular organismal process • system process • digestion • secretion • transport • digestive system process • acid secretion • gastric acid secretion • establishment of localization • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • cell population proliferation • positive regulation of cell population proliferation • regulation of cell population proliferation • positive regulation of biological process • positive regulation of cellular process • cholecystokinin signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • cell surface receptor signaling pathway • developmental process • gland development • animal organ development • anatomical structure development • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organism development • digestive system development • tube development • digestive tract development • system development • chemical homeostasis • homeostatic process • regulation of pH • monoatomic ion homeostasis • monoatomic cation homeostasis • pH reduction • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • enzyme regulator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • enzyme activator activity • GTPase activator activity • molecular function regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • G-protein beta/gamma-subunit complex binding • G protein activity • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • regulation of signaling • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • regulation of protein modification process • regulation of catalytic activity • regulation of protein phosphorylation • negative regulation of biological process • negative regulation of phosphate metabolic process • negative regulation of catalytic activity • regulation of transferase activity • regulation of primary metabolic process • negative regulation of kinase activity • negative regulation of transferase activity • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • negative regulation of protein modification process • negative regulation of cellular process • protein metabolic process • phosphorus metabolic process • protein modification process • negative regulation of protein metabolic process • negative regulation of macromolecule metabolic process • protein phosphorylation • phosphorylation • regulation of protein metabolic process • negative regulation of metabolic process • negative regulation of molecular function • primary metabolic process • negative regulation of protein kinase activity • regulation of protein kinase activity • regulation of macromolecule metabolic process • regulation of molecular function • regulation of kinase activity • negative regulation of protein phosphorylation • macromolecule modification • negative regulation of phosphorus metabolic process • regulation of phosphorylation • regulation of phosphorus metabolic process • metabolic process • macromolecule metabolic process • negative regulation of phosphorylation • regulation of metabolic process • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • nuclear membrane • nucleus • endomembrane system • organelle envelope • nuclear envelope • Golgi apparatus • cytosolic region • postsynapse • postsynaptic cytosol • molecular transducer activity • signaling receptor activity • signaling receptor activator activity • hormone activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide activity • neuropeptide hormone activity • peptide hormone receptor binding • hormone receptor binding • neuron migration • cellular developmental process • nervous system development • generation of neurons • neurogenesis • cell differentiation • cell migration • cell motility • behavior • eating behavior • feeding behavior • axonogenesis • cell projection organization • plasma membrane bounded cell projection morphogenesis • cell development • neuron projection development • cell morphogenesis • cellular component organization • cell projection morphogenesis • neuron differentiation • neuron projection morphogenesis • cellular component organization or biogenesis • plasma membrane bounded cell projection organization • axon development • cell morphogenesis involved in neuron differentiation • anatomical structure morphogenesis • neuron development • axon
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	TYS
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	TYS
Name	O-SULFO-L-TYROSINE
Synonyms
Identifier
Formula	C9 H11 N O6 S
Molecular Weight	261.252
SMILES
PubChem	514186
Formal Charge	0
Total Atoms	28
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	6


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P32239
Sequence	>8IA7_nogp_Chain_R E L A I R I T L Y A V I F L M S V G G N M L I I V V L G L S R R L R T V T N A F L L S L A V S D L L L A V A C M P F T L L P N L M G T F I F G T V I C K A V S Y L M G V S V S V S T L S L V A I A L E R Y S A I C R P L Q A R V W Q T R S H A A R V I V A T W L L S G L L M V P Y P V Y T V V Q P V G P R V L Q C V H R W P S A R V R Q T W S V L L L L L L F F I P G V V M A V A Y G L I S R E L Y L G K L L A K K R V V R M L L V I V V L F F L C W L P V Y S A N T W R A F D G P G A H R A L S G A P I S F I H L L S Y A S A C V N P L V Y C F M H R R F R Q A C L E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IA7	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-	chim(NtGi1L-Gq)/β1/γ2	3.1	2023-12-06	10.1038/s41421-022-00420-3
	8IA7 (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Cholecystokinin-8	-		3.1	2023-12-06	10.1038/s41421-022-00420-3
	7XOW	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-	chim(NtGi1-Gq)/β1/γ2	3.1	2022-07-20	10.1038/s41421-022-00420-3
	7XOW (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin	-		3.1	2022-07-20	10.1038/s41421-022-00420-3
	7F8W	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	chim(NtGsL-Gq)/β1/γ2	3.1	2021-10-13	10.1038/s41589-021-00866-8
	7F8W (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.1	2021-10-13	10.1038/s41589-021-00866-8
	7F8V	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-	Gi2/β1/γ2	3.3	2021-10-13	10.1038/s41589-021-00866-8
	7F8V (No Gprot)	A	Peptide	Cholecystokinin	CCK_B	Homo sapiens	Gastrin-17	-		3.3	2021-10-13	10.1038/s41589-021-00866-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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