Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 6.3954126
2A:A:N50 5.928599
3A:A:K53 5.5075499
4A:A:M60 4.854129
5A:A:H64 8.31408
6A:A:F212 9.12754129
7A:A:F219 6.925128
8A:A:H220 6.15507
9A:A:M221 4.7725128
10A:A:F222 6.8375417
11A:A:V224 6.8375419
12A:A:Q227 4.92519
13A:A:K233 6.7475419
14A:A:W234 7.732519
15A:A:F238 6.75286719
16A:A:I244 3.665408
17A:A:I245 4407
18A:A:V248 4.4925407
19A:A:D249 11.595498
20A:A:S251 3.375499
21A:A:Y253 6.2125408
22A:A:F273 6.158569
23A:A:W277 7.73833666
24A:A:W281 8.442545
25A:A:L289 4.875469
26A:A:L291 4.39408
27A:A:L297 3.5275408
28A:A:F312 4.6475408
29A:A:F315 9.20254176
30A:A:Y318 5.7475406
31A:A:E330 10.4325463
32A:A:K338 5.386565
33A:A:F340 7.7745177
34A:A:R342 7.8464
35A:A:F345 8.3625468
36A:A:S349 4.045467
37A:A:Y358 4.2725454
38A:A:Y360 6.364508
39A:A:F363 6.1225465
40A:A:F376 5.8275408
41A:A:D377 9.1225455
42A:A:D381 7.966557
43A:A:K385 6.995455
44B:B:I18 3.74407
45B:B:D27 5.395408
46B:B:R49 4.584137
47B:B:H54 9.298579
48B:B:K57 11449
49B:B:M61 3.912576
50B:B:W63 8.156577
51B:B:L70 5.4425475
52B:B:V71 4.1645108
53B:B:Q75 6.7409
54B:B:L79 4.81254107
55B:B:W82 9.14779
56B:B:T86 5.40754146
57B:B:K89 7.298579
58B:B:I93 5.5675407
59B:B:L95 3.985108
60B:B:W99 9.2875419
61B:B:Y105 4.157147106
62B:B:Y111 4.955414
63B:B:L117 4.1425419
64B:B:I120 3.5175406
65B:B:I123 3.198516
66B:B:Y124 6.4525406
67B:B:L139 7.2425419
68B:B:H142 8.084519
69B:B:Y145 7.73518
70B:B:C149 3.0625418
71B:B:F151 3.77167609
72B:B:L152 3.85403
73B:B:I157 3.5675417
74B:B:T159 4.49667619
75B:B:S160 5.1725436
76B:B:D163 8.332519
77B:B:W169 9.278518
78B:B:I171 3.48416
79B:B:F180 7.625437
80B:B:H183 7.535639
81B:B:D186 6.445419
82B:B:V187 4.702539
83B:B:L190 4.6325435
84B:B:F199 5.865639
85B:B:S201 4.6075439
86B:B:D205 6.7775439
87B:B:K209 9.2775436
88B:B:W211 6.93429738
89B:B:F222 7.49518
90B:B:H225 7.59719
91B:B:D228 8.508519
92B:B:I232 5.09418
93B:B:F234 5.065405
94B:B:F235 7.067147116
95B:B:F241 7.165616
96B:B:T243 7.0575418
97B:B:D247 9.08519
98B:B:L252 4.2725407
99B:B:F253 6.236516
100B:B:D254 5.12409
101B:B:D258 8.874517
102B:B:Q259 5.1025406
103B:B:Y264 6.08505
104B:B:Y289 6.06667647
105B:B:D290 6.774546
106B:B:N295 5.4125446
107B:B:W297 5.73548
108B:B:L300 3.5075406
109B:B:K301 6.4725405
110B:B:H311 8.56589
111B:B:R314 12.098548
112B:B:V327 3.464586
113B:B:W332 11.0733649
114B:B:D333 9.0775489
115B:B:F335 5.3025404
116B:B:K337 6.95486
117B:B:W339 6.75833689
118G:G:R27 3.82408
119G:G:Y40 7.45754116
120G:G:D48 8.7375409
121G:G:L51 4.088506
122G:G:P60 5.15754139
123G:G:F61 5.856676138
124R:R:F17 7.15254155
125R:R:I19 2.6965195
126R:R:E34 7.864216
127R:R:I41 7.77254216
128R:R:F43 8.24406
129R:R:D45 6.90254218
130R:R:R55 7.54429729
131R:R:W66 3.5654184
132R:R:R81 11.15754233
133R:R:H93 7.63667625
134R:R:N96 5.368526
135R:R:W97 10.794527
136R:R:L98 45227
137R:R:F105 8.8975408
138R:R:L108 4.1525407
139R:R:I110 5.56409
140R:R:F118 8.54409
141R:R:L133 4.0854228
142R:R:I147 5.165404
143R:R:N148 5.1854243
144R:R:K156 9.094232
145R:R:E159 6.915405
146R:R:L168 8.48403
147R:R:N176 7.5765253
148R:R:L185 5.195423
149R:R:P187 6.3875428
150R:R:F188 6.2475427
151R:R:S194 3.334268
152R:R:F195 5.1525267
153R:R:H205 8.10667659
154R:R:M209 6.324559
155R:R:H212 6.13456
156R:R:K214 9.27455
157R:R:S220 4.9325458
158R:R:M221 4.885456
159R:R:F234 4.855409
160R:R:Y241 9.146527
161R:R:F242 4.872526
162R:R:N257 3.37754283
163R:R:Y271 8.225626
164R:R:H275 7.022529
165R:R:I278 5.88408
166R:R:K285 5.25408
167R:R:L286 6.3475409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D83 B:B:T86 25.1495.78NoYes1486
2B:B:N88 B:B:T86 20.19848.77NoYes1476
3A:A:N23 B:B:N88 38.95699.54NoNo077
4A:A:N23 B:B:K89 37.55186.99NoYes079
5A:A:I26 B:B:K89 11.74885.82NoYes099
6B:B:K89 B:B:W82 13.895713.92YesYes799
7B:B:D83 B:B:R68 46.736216.68NoNo085
8B:B:L69 B:B:R68 64.20243.64NoNo055
9B:B:L69 B:B:Y105 65.56953.52NoYes056
10B:B:G109 B:B:Y105 84.90475.79NoYes056
11B:B:G109 B:B:S108 85.58831.86NoNo056
12B:B:N110 B:B:S108 43.14238.94NoNo146
13B:B:N110 B:B:Y111 43.49533.49NoYes144
14B:B:I123 B:B:Y111 88.43643.63YesYes164
15B:B:I123 B:B:L139 53.21662.85YesYes169
16B:B:C121 B:B:L139 17.89474.76NoYes189
17B:B:C121 B:B:T159 17.81543.38NoYes189
18B:B:H142 B:B:T159 71.9865.48YesYes199
19B:B:H142 B:B:S161 89.126516.74YesNo199
20B:B:G162 B:B:S161 89.611.86NoNo199
21B:B:G162 B:B:Y145 87.81638.69NoYes198
22A:A:Q227 B:B:Y145 88.296810.15YesYes198
23B:B:D154 B:B:S108 43.14238.83NoNo166
24B:B:D154 B:B:Y111 43.49538.05NoYes164
25B:B:L139 B:B:W169 35.566817.08YesYes198
26B:B:T159 B:B:W169 17.92137.28YesYes198
27B:B:F151 B:B:I123 18.13675.02YesYes096
28B:B:F151 B:B:I157 18.48355.02YesYes097
29B:B:I157 B:B:T159 36.21073.04YesYes179
30B:B:I123 B:B:I171 17.89312.94YesYes166
31B:B:I157 B:B:I171 17.99212.94YesYes176
32B:B:A167 B:B:W169 17.87333.89NoYes148
33B:B:A167 B:B:H142 18.13352.93NoYes149
34A:A:Q227 A:A:W234 78.48273.29YesYes199
35A:A:F238 A:A:W234 30.72294.01YesYes199
36A:A:C237 A:A:F238 18.61464.19NoYes089
37A:A:C237 B:B:Q75 16.42234.58NoYes089
38B:B:K57 B:B:Q75 32.597612.2YesYes099
39B:B:R68 B:B:Y85 17.239616.46NoNo054
40B:B:Y85 G:G:P60 11.167411.13NoYes1349
41B:B:R283 G:G:L51 16.14183.64NoYes096
42B:B:L300 B:B:R283 16.81534.86YesNo069
43B:B:A299 B:B:L300 19.82011.58NoYes056
44B:B:A299 B:B:L252 20.04881.58NoYes057
45B:B:L252 B:B:Y264 21.82128.21YesYes075
46B:B:W297 B:B:Y264 25.75368.68YesYes085
47B:B:W297 B:B:Y289 26.25223.86YesYes487
48B:B:C271 B:B:Y289 28.2964.03NoYes457
49B:B:C271 B:B:D290 29.51473.11NoYes456
50A:A:W281 B:B:D290 15.01814.47YesYes456
51A:A:W281 B:B:W332 15.91184.69YesYes459
52B:B:K57 B:B:W332 31.895615.08YesYes499
53B:B:D290 B:B:R314 14.888815.48YesYes468
54B:B:R314 B:B:W332 15.456321.99YesYes489
55A:A:R231 A:A:W234 10012NoYes099
56A:A:D272 A:A:R231 99.85161.19NoNo089
57A:A:D272 A:A:F246 99.70471.19NoNo089
58A:A:F246 A:A:V248 99.55782.62NoYes097
59A:A:L291 A:A:V248 95.77994.47YesYes087
60A:A:I341 A:A:L291 92.94242.85NoYes088
61A:A:I341 A:A:S250 91.99373.1NoNo086
62A:A:L297 A:A:S250 92.7336.01YesNo086
63A:A:L297 A:A:S251 91.71483YesYes089
64A:A:D249 A:A:S251 91.01982.94YesYes989
65A:A:D249 A:A:N50 90.691110.77YesYes989
66A:A:N50 A:A:S51 90.07062.98YesNo999
67A:A:S51 A:A:V247 89.08796.46NoNo997
68A:A:N292 A:A:V247 89.07565.91NoNo097
69A:A:I56 A:A:N292 88.74252.83NoNo079
70A:A:I56 A:A:M60 83.9282.92NoYes079
71A:A:F212 A:A:M60 74.7476.22YesYes1299
72A:A:F212 A:A:F219 74.288510.72YesYes1298
73A:A:F238 A:A:L44 13.80516.09YesNo199
74A:A:L44 A:A:L46 15.051111.07NoNo098
75A:A:I244 A:A:L46 13.98262.85YesNo088
76A:A:F238 B:B:W99 17.265220.04YesYes199
77B:B:Q75 B:B:W99 16.90384.38YesYes099
78A:A:F219 A:A:F376 73.52593.22YesYes088
79A:A:K233 B:B:Y145 11.51463.58YesYes198
80A:A:K233 B:B:D228 11.01448.3YesYes199
81A:A:I244 A:A:V287 10.23863.07YesNo086
82A:A:F376 A:A:T380 73.19556.49YesNo086
83A:A:T380 R:R:H205 16.4514.11NoYes069
84A:A:T380 R:R:N112 56.87662.92NoNo068
85R:R:H205 R:R:H224 15.03110.75YesNo099
86R:R:H224 R:R:L202 14.11446.43NoNo099
87R:R:L202 R:R:L228 13.9334.15NoNo097
88R:R:I199 R:R:L228 13.57064.28NoNo077
89R:R:I199 R:R:V231 13.02736.14NoNo077
90R:R:F105 R:R:V125 14.88935.24YesNo087
91R:R:L108 R:R:V125 15.10685.96YesNo077
92R:R:F118 R:R:L108 15.91233.65YesYes097
93R:R:F113 R:R:F118 56.058918.22NoYes089
94R:R:F113 R:R:S201 56.23015.28NoNo2789
95R:R:N112 R:R:S201 56.64762.98NoNo089
96B:B:L284 G:G:L51 11.01412.77NoYes056
97B:B:I43 B:B:L284 10.75544.28NoNo035
98B:B:I43 B:B:M45 10.23742.92NoNo034
99B:B:V71 B:B:Y105 14.7665.05YesYes1086
100B:B:L79 B:B:V71 11.82274.47YesYes1078
101B:B:D247 B:B:H225 10.29013.78YesYes199
102B:B:D247 B:B:S227 10.84315.89YesNo196
103R:R:F118 R:R:L107 39.786.09YesNo098
104R:R:L107 R:R:S194 39.36283NoYes088
105R:R:S103 R:R:S194 30.23173.26NoYes2688
106R:R:S103 R:R:T191 31.00486.4NoNo088
107R:R:T100 R:R:T191 23.68794.71NoNo088
108R:R:P187 R:R:T100 23.2955.25YesNo088
109R:R:N96 R:R:P187 12.72083.26YesYes268
110R:R:N92 R:R:N96 12.93438.17NoYes286
111R:R:N92 R:R:W88 12.70527.91NoNo084
112R:R:M172 R:R:W88 12.468124.43NoNo034
113R:R:P187 R:R:W97 12.071313.51YesYes287
114R:R:H93 R:R:W97 11.122515.87YesYes257
115R:R:F195 R:R:F234 17.45327.5YesYes079
116R:R:F234 R:R:I278 16.21375.02YesYes098
117R:R:H275 R:R:I278 12.93045.3YesYes098
118R:R:F195 R:R:V231 10.65233.93YesNo077
119R:R:F105 R:R:F43 13.695313.93YesYes086
120R:R:F43 R:R:I47 13.13186.28YesNo069
121R:R:I47 R:R:L102 12.68075.71NoNo099
122R:R:L102 R:R:L48 13.11862.77NoNo098
123A:A:Q19 B:B:N88 20.176711.88NoNo1447
124A:A:Q19 B:B:D83 20.88397.83NoNo1448
125B:B:D228 B:B:S227 10.8365.89YesNo196
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7XP4
Class T
SubFamily Sensory
Type Taste2
SubType T2R46
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGt3)/Beta1/Gamma2
PDB Resolution 3.01
Date 2022-10-12
D.O.I. 10.1126/science.abo1633
Net Summary
Imin 2.83
Number of Linked Nodes 857
Number of Links 1019
Number of Hubs 167
Number of Links mediated by Hubs 601
Number of Communities 28
Number of Nodes involved in Communities 234
Number of Links involved in Communities 324
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 1780635
Length Of Smallest Path 3
Average Path Length 38.1387
Length of Longest Path 79
Minimum Path Strength 1.19
Average Path Strength 6.11093
Maximum Path Strength 20.365
Minimum Path Correlation 0.7
Average Path Correlation 0.987679
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.75439
Average % Of Corr. Nodes 41.7794
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 49.8312
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7XP4_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHSGIFETK FQVDKVNFH MFDVGGQRD ERRKWIQCF 
NDVTAIIFV VDSSDYNRL QEALNDFKS IWNNRWLRT ISVILFLNK 
QDLLAEKVL AGKSKIEDY FPEFARYTT PEDATPEPG EDPRVTRAK 
YFIRDEFLR ISTASGDGR HYCYPHFTC AVDTQNVKF VFDAVTDII 
IKENLKDCG LF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XP4_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XP4_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP59540
Sequence
>7XP4_Chain_R
TFLPIIFSI LIVVTFVIG NFANGFIAL VNSIEWFKR QKISFADQI 
LTALAVSRV GLLWVLVLN WYATELNPA FNSIEVRIT AYNVWAVIN 
HFSNWLATS LSIFYLLKI ANFSNLIFL HLKRRVKSV VLVILLGPL 
LFLVCHLFV INMNQIIWT KEYEGNMTW KIKLRSAMY LSNTTVTIL 
ANLVPFTLT LISFLLLIC SLCKHLKKM QLHGKGSQD PSMKVHIKA 
LQTVTSFLL LCAIYFLSI IMSVWSFES LENKPVFMF CEAIAFSYP 
STHPFILIW GNKKLKQTF LSVLWHVRY WV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XP4TSensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/&β;1/&γ;23.012022-10-1210.1126/science.abo1633
7XP5TSensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/&β;1/&γ;23.082022-10-1210.1126/science.abo1633
7XP6TSensoryTaste2T2R46Homo sapiensStrychnine-chim(Gs-CtGt3)/&β;1/&γ;23.012022-10-1210.1126/science.abo1633




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XP4.zip



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