psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P6	R:R:T3	3.5	No	No	0	3	5
2	R:R:L5	R:R:W164	3.42	No	Yes	2	4	2
3	R:R:K165	R:R:L5	12.69	Yes	No	2	4	4
4	R:R:F9	R:R:K165	6.2	Yes	Yes	2	3	4
5	R:R:F9	R:R:L168	4.87	Yes	No	0	3	3
6	R:R:F9	R:R:R169	12.83	Yes	Yes	2	3	4
7	R:R:F9	R:R:M172	8.71	Yes	No	0	3	3
8	R:R:S10	R:R:W66	3.71	No	Yes	0	5	4
9	R:R:I13	R:R:W66	10.57	No	Yes	0	4	4
10	R:R:F269	R:R:I13	7.54	No	No	0	4	4
11	R:R:V14	R:R:W66	3.68	No	Yes	0	5	4
12	R:R:S273	R:R:T16	3.2	No	No	0	8	7
13	R:R:F17	R:R:N21	3.62	Yes	No	5	5	5
14	R:R:F17	R:R:W60	6.01	Yes	No	5	5	1
15	R:R:F17	R:R:V63	6.55	Yes	No	0	5	4
16	R:R:F277	R:R:I19	5.02	No	No	0	5	5
17	R:R:N21	R:R:W60	6.78	No	No	5	5	1
18	R:R:A23	R:R:P276	3.74	No	No	0	7	9
19	R:R:A23	R:R:F277	4.16	No	No	0	7	5
20	R:R:N24	R:R:R55	6.03	No	Yes	0	9	9
21	R:R:N24	R:R:P276	11.4	No	No	0	9	9
22	R:R:F26	R:R:T289	3.89	No	No	0	8	6
23	R:R:F26	R:R:F290	4.29	No	No	0	8	5
24	R:R:F26	R:R:V293	3.93	No	No	0	8	6
25	R:R:I27	R:R:N31	4.25	No	Yes	0	9	8
26	R:R:A52	R:R:I27	3.25	No	No	0	8	9
27	R:R:I27	R:R:I280	5.89	No	No	0	9	9
28	R:R:N31	R:R:V30	4.43	Yes	No	0	8	8
29	R:R:T289	R:R:V30	6.35	No	No	0	6	8
30	R:R:D45	R:R:N31	4.04	Yes	Yes	0	8	8
31	R:R:N31	R:R:T49	4.39	Yes	No	0	8	6
32	R:R:L286	R:R:N31	4.12	No	Yes	0	9	8
33	R:R:E34	R:R:R38	12.79	No	No	0	6	5
34	R:R:D45	R:R:E34	6.5	Yes	No	0	8	6
35	R:R:E34	R:R:K285	10.8	No	No	0	6	8
36	R:R:I41	R:R:W35	9.4	No	No	0	6	5
37	R:R:D45	R:R:I41	5.6	Yes	No	0	8	6
38	R:R:I41	R:R:Q46	4.12	No	No	0	6	6
39	R:R:D45	R:R:S42	5.89	Yes	No	0	8	8
40	R:R:F43	R:R:Q46	3.51	Yes	No	0	6	6
41	R:R:F43	R:R:I47	7.54	Yes	No	6	6	9
42	R:R:F105	R:R:F43	12.86	Yes	Yes	6	8	6
43	R:R:F43	R:R:K126	22.33	Yes	No	0	6	7
44	R:R:F43	R:R:V129	3.93	Yes	No	0	6	7
45	R:R:I47	R:R:L102	7.14	No	No	0	9	9
46	R:R:F105	R:R:I47	3.77	Yes	No	6	8	9
47	R:R:L279	R:R:L48	5.54	No	No	0	9	8
48	R:R:A50	R:R:L98	4.73	No	No	0	6	7
49	R:R:L51	R:R:R55	15.79	No	Yes	0	9	9
50	R:R:A99	R:R:L51	3.15	No	No	0	8	9
51	R:R:S54	R:R:S95	6.52	No	No	0	8	8
52	R:R:R55	R:R:S95	7.91	Yes	No	0	9	8
53	R:R:R55	R:R:Y271	15.43	Yes	Yes	3	9	6
54	R:R:P272	R:R:R55	4.32	No	Yes	3	8	9
55	R:R:H275	R:R:R55	11.28	Yes	Yes	3	9	9
56	R:R:V56	R:R:W60	8.58	No	No	0	6	1
57	R:R:L58	R:R:L62	5.54	No	No	0	4	4
58	R:R:L58	R:R:P272	3.28	No	No	0	4	8
59	R:R:V61	R:R:V87	3.21	No	No	0	4	3
60	R:R:L62	R:R:W88	4.56	No	No	0	4	4
61	R:R:F269	R:R:L62	4.87	No	No	0	4	4
62	R:R:A84	R:R:N65	4.69	No	No	0	3	4
63	R:R:E70	R:R:W66	7.63	No	Yes	0	4	4
64	R:R:L71	R:R:W66	6.83	No	Yes	0	4	4
65	R:R:L71	R:R:Y67	8.21	No	No	0	4	4
66	R:R:N72	R:R:Y67	18.61	No	No	0	3	4
67	R:R:F75	R:R:N72	6.04	No	No	0	2	3
68	R:R:S77	R:R:V80	6.46	No	No	0	2	2
69	R:R:I78	R:R:Y158	10.88	No	No	0	4	1
70	R:R:E79	R:R:T83	4.23	No	No	0	1	3
71	R:R:R81	R:R:Y85	9.26	No	No	0	3	2
72	R:R:E157	R:R:R81	10.47	No	No	0	1	3
73	R:R:R81	R:R:Y158	10.29	No	No	0	3	1
74	R:R:I82	R:R:Q151	8.23	No	No	0	2	3
75	R:R:N176	R:R:Y85	8.14	Yes	No	0	3	2
76	R:R:V179	R:R:Y85	3.79	No	No	0	4	2
77	R:R:L144	R:R:N86	5.49	No	No	0	5	3
78	R:R:N92	R:R:W88	9.04	No	No	1	8	4
79	R:R:W88	R:R:Y173	7.72	No	No	1	4	2
80	R:R:A89	R:R:L144	3.15	No	No	0	5	5
81	R:R:N92	R:R:N96	6.81	No	No	0	8	6
82	R:R:N92	R:R:Y173	8.14	No	No	1	8	2
83	R:R:H93	R:R:W97	14.81	Yes	Yes	0	5	7
84	R:R:H93	R:R:L137	6.43	Yes	No	0	5	4
85	R:R:H93	R:R:L140	16.71	Yes	No	0	5	5
86	R:R:H93	R:R:L182	5.14	Yes	No	0	5	4
87	R:R:F94	R:R:L98	8.53	No	No	0	5	7
88	R:R:F94	R:R:L137	4.87	No	No	0	5	4
89	R:R:N184	R:R:N96	4.09	Yes	No	0	5	6
90	R:R:N96	R:R:P187	3.26	No	Yes	0	6	8
91	R:R:T100	R:R:W97	4.85	Yes	Yes	4	8	7
92	R:R:I132	R:R:W97	3.52	No	Yes	0	6	7
93	R:R:P136	R:R:W97	16.21	No	Yes	0	8	7
94	R:R:V186	R:R:W97	3.68	No	Yes	4	6	7
95	R:R:P187	R:R:W97	12.16	Yes	Yes	4	8	7
96	R:R:L133	R:R:L98	6.92	No	No	0	8	7
97	R:R:P187	R:R:T100	5.25	Yes	Yes	4	8	8
98	R:R:T100	R:R:T191	4.71	Yes	No	0	8	8
99	R:R:S101	R:R:V129	3.23	No	No	0	5	7
100	R:R:L133	R:R:S101	9.01	No	No	0	8	5
101	R:R:L102	R:R:Y106	8.21	No	No	0	9	9
102	R:R:S103	R:R:T191	6.4	No	No	0	8	8
103	R:R:S103	R:R:S194	6.52	No	No	0	8	8
104	R:R:F195	R:R:S103	11.89	Yes	No	0	7	8
105	R:R:F105	R:R:K109	7.44	Yes	No	0	8	9
106	R:R:L107	R:R:L108	4.15	No	No	0	8	7
107	R:R:L107	R:R:S194	7.51	No	No	0	8	8
108	R:R:I110	R:R:L198	4.28	No	No	0	9	9
109	R:R:A111	R:R:S201	3.42	No	No	0	8	9
110	R:R:F113	R:R:F118	16.08	No	No	0	8	9
111	R:R:I117	R:R:N115	12.74	No	No	0	5	8
112	R:R:H120	R:R:R124	11.28	No	No	0	5	7
113	R:R:G135	R:R:P136	4.06	No	No	0	5	8
114	R:R:L140	R:R:L144	4.15	No	No	0	5	5
115	R:R:H143	R:R:V146	5.54	No	No	0	6	3
116	R:R:H143	R:R:T178	6.85	No	No	0	6	3
117	R:R:N148	R:R:Q151	3.96	No	No	0	3	3
118	R:R:E157	R:R:Q151	8.92	No	No	0	1	3
119	R:R:K156	R:R:W154	5.8	No	No	0	2	4
120	R:R:E157	R:R:N176	7.89	No	Yes	0	1	3
121	R:R:G160	R:R:N161	3.39	No	No	0	4	9
122	R:R:L168	R:R:M162	4.24	No	No	0	3	4
123	R:R:K167	R:R:T163	6.01	No	No	0	4	8
124	R:R:K165	R:R:W164	3.48	Yes	Yes	2	4	2
125	R:R:I166	R:R:W164	5.87	No	Yes	0	3	2
126	R:R:K258	R:R:W164	8.12	No	Yes	0	5	2
127	R:R:K165	R:R:R169	3.71	Yes	Yes	2	4	4
128	R:R:K165	R:R:M262	4.32	Yes	No	0	4	4
129	R:R:F261	R:R:I166	5.02	Yes	No	0	1	3
130	R:R:E265	R:R:R169	12.79	No	Yes	0	3	4
131	R:R:F269	R:R:R169	16.03	No	Yes	0	4	4
132	R:R:L174	R:R:Y173	9.38	No	No	1	1	2
133	R:R:L174	R:R:T180	11.79	No	No	1	1	2
134	R:R:L174	R:R:N184	5.49	No	Yes	1	1	5
135	R:R:N184	R:R:T180	5.85	Yes	No	1	5	2
136	R:R:I181	R:R:L185	5.71	No	No	0	5	3
137	R:R:I245	R:R:N184	5.66	No	Yes	0	4	5
138	R:R:P187	R:R:V186	3.53	Yes	No	4	8	6
139	R:R:F188	R:R:F242	4.29	No	No	0	7	6
140	R:R:F188	R:R:Y271	12.38	No	Yes	0	7	6
141	R:R:C238	R:R:T191	5.07	No	No	0	7	8
142	R:R:L192	R:R:L235	4.15	No	No	0	7	7
143	R:R:F195	R:R:V231	3.93	Yes	No	0	7	7
144	R:R:F195	R:R:F234	5.36	Yes	Yes	0	7	9
145	R:R:L196	R:R:L235	4.15	No	No	0	5	7
146	R:R:L198	R:R:V231	4.47	No	No	0	9	7
147	R:R:I199	R:R:V231	6.14	No	No	0	7	7
148	R:R:I199	R:R:T232	4.56	No	No	0	7	6
149	R:R:H224	R:R:L202	9	No	No	0	9	9
150	R:R:C203	R:R:L228	3.17	No	No	0	4	7
151	R:R:H205	R:R:H224	9.55	No	No	0	9	9
152	R:R:H224	R:R:L206	7.71	No	No	0	9	6
153	R:R:G215	R:R:Q217	4.93	No	No	0	5	6
154	R:R:D218	R:R:M221	5.54	No	No	0	8	6
155	R:R:I225	R:R:Q229	4.12	No	No	0	6	7
156	R:R:S233	R:R:T230	3.2	No	No	7	8	8
157	R:R:F234	R:R:T230	3.89	Yes	No	7	9	8
158	R:R:F234	R:R:S233	3.96	Yes	No	7	9	8
159	R:R:S233	R:R:W281	6.18	No	No	0	8	5
160	R:R:F234	R:R:I278	10.05	Yes	No	0	9	8
161	R:R:L237	R:R:Y241	10.55	No	Yes	0	7	7
162	R:R:I278	R:R:L237	8.56	No	No	0	8	7
163	R:R:Y241	R:R:Y271	19.86	Yes	Yes	0	7	6
164	R:R:T274	R:R:Y241	7.49	No	Yes	0	5	7
165	R:R:I267	R:R:S244	6.19	No	No	0	5	5
166	R:R:A268	R:R:S244	3.42	No	No	0	5	5
167	R:R:C264	R:R:M247	8.1	No	No	0	3	5
168	R:R:E265	R:R:S248	8.62	No	No	0	3	5
169	R:R:E253	R:R:W250	10.9	No	No	0	2	4
170	R:R:F261	R:R:S251	14.53	Yes	No	0	1	5
171	R:R:E256	R:R:S254	8.62	No	No	0	1	1
172	R:R:F261	R:R:L255	4.87	Yes	No	0	1	3
173	R:R:N257	R:R:V260	5.91	No	No	0	3	3
174	R:R:E265	R:R:F261	11.66	No	Yes	0	3	1
175	R:R:S270	R:R:S273	3.26	No	No	0	5	8
176	R:R:S270	R:R:T274	3.2	No	No	0	5	5
177	R:R:P272	R:R:Y271	5.56	No	Yes	3	8	6
178	R:R:H275	R:R:Y271	5.44	Yes	Yes	3	9	6
179	R:R:H275	R:R:I278	3.98	Yes	No	0	9	8
180	R:R:H275	R:R:L279	11.57	Yes	No	0	9	9
181	R:R:K287	R:R:W281	5.8	No	No	0	7	5
182	R:R:L286	R:R:N283	13.73	No	No	0	9	9
183	R:R:K285	R:R:T289	4.5	No	No	0	8	6
184	R:R:L291	R:R:W295	7.97	No	No	0	5	3
185	R:R:H296	R:R:S292	4.18	No	No	0	3	5
186	R:R:I104	R:R:S194	3.1	No	No	0	6	8
187	R:R:K126	R:R:V125	3.04	No	No	0	7	7
188	R:R:I181	R:R:T180	3.04	No	No	0	5	2
189	R:R:F234	R:R:G282	3.01	Yes	No	0	9	8
190	R:R:N112	R:R:S201	2.98	No	No	0	8	9
191	R:R:L140	R:R:V179	2.98	No	No	0	5	4
192	R:R:N150	R:R:V146	2.96	No	No	0	1	3
193	R:R:L12	R:R:T16	2.95	No	No	0	6	7
194	R:R:L190	R:R:T100	2.95	No	Yes	0	5	8
195	R:R:W295	R:R:Y299	2.89	No	No	0	3	3
196	R:R:E79	R:R:S77	2.87	No	No	0	1	2
197	R:R:I33	R:R:L29	2.85	No	No	0	5	6
198	R:R:I91	R:R:L58	2.85	No	No	0	5	4
199	R:R:I246	R:R:L185	2.85	No	No	0	5	3
200	R:R:I193	R:R:L197	2.85	No	No	0	4	7
201	R:R:I199	R:R:L228	2.85	No	No	0	7	7
202	R:R:I225	R:R:L206	2.85	No	No	0	6	6
203	R:R:M149	R:R:N150	2.8	No	No	0	3	1
204	R:R:A44	R:R:F105	2.77	No	Yes	0	6	8
205	R:R:L107	R:R:L197	2.77	No	No	0	8	7
206	R:R:L198	R:R:L202	2.77	No	No	0	9	9
207	R:R:L202	R:R:L228	2.77	No	No	0	9	7
208	R:R:M221	R:R:Q210	2.72	No	No	0	6	6
209	R:R:E159	R:R:K156	2.7	No	No	0	5	2
210	R:R:F113	R:R:S201	2.64	No	No	0	8	9
211	R:R:F261	R:R:S170	2.64	Yes	No	0	1	4
212	R:R:H205	R:R:M209	2.63	No	No	0	9	9
213	R:R:F17	R:R:V18	2.62	Yes	No	0	5	5
214	R:R:F145	R:R:V141	2.62	No	No	0	3	3
215	R:R:F242	R:R:T189	2.59	No	No	0	6	4
216	R:R:F36	R:R:K37	2.48	No	No	0	5	7
217	R:R:F118	R:R:K122	2.48	No	No	0	9	9
218	R:R:F252	R:R:K167	2.48	No	No	0	2	4
219	R:R:V301	R:R:W300	2.45	No	No	0	4	3
220	R:R:F118	R:R:L108	2.44	No	No	0	9	7
221	R:R:F195	R:R:L235	2.44	Yes	No	0	7	7
222	R:R:I267	R:R:Y241	2.42	No	Yes	0	5	7
223	R:R:N76	R:R:Y158	2.33	No	No	0	3	1
224	R:R:N150	R:R:W154	2.26	No	No	0	1	4
225	R:R:Q288	R:R:W295	2.19	No	No	0	6	3
226	R:R:R123	R:R:R124	2.13	No	No	0	4	7
227	R:R:A28	R:R:G25	1.95	No	No	0	7	7
228	R:R:G20	R:R:S273	1.86	No	No	0	9	8
229	R:R:G57	R:R:V56	1.84	No	No	0	1	6
230	R:R:A28	R:R:A52	1.79	No	No	0	7	8
231	R:R:C264	R:R:S244	1.72	No	No	0	3	5
232	R:R:G20	R:R:L59	1.71	No	No	0	9	7
233	R:R:A171	R:R:S175	1.71	No	No	0	4	4
234	R:R:C264	R:R:V260	1.71	No	No	0	3	3
235	R:R:A28	R:R:V53	1.7	No	No	0	7	5
236	R:R:K258	R:R:P259	1.67	No	No	0	5	1
237	R:R:L5	R:R:P6	1.64	No	No	0	4	3
238	R:R:E159	R:R:G160	1.64	No	No	0	5	4
239	R:R:N72	R:R:P73	1.63	No	No	0	3	4
240	R:R:N76	R:R:P73	1.63	No	No	0	3	4
241	R:R:S127	R:R:V131	1.62	No	No	0	5	4
242	R:R:D218	R:R:P219	1.61	No	No	0	8	6
243	R:R:V14	R:R:V15	1.6	No	No	0	5	5
244	R:R:V293	R:R:V297	1.6	No	No	0	6	6
245	R:R:V297	R:R:V301	1.6	No	No	0	6	4
246	R:R:G213	R:R:H212	1.59	No	No	0	6	6
247	R:R:A266	R:R:L12	1.58	No	No	0	4	6
248	R:R:A239	R:R:L192	1.58	No	No	0	6	7
249	R:R:T177	R:R:T178	1.57	No	No	0	3	3
250	R:R:I7	R:R:S10	1.55	No	No	0	5	5
251	R:R:I11	R:R:S10	1.55	No	No	0	6	5
252	R:R:I91	R:R:V87	1.54	No	No	0	5	3
253	R:R:I104	R:R:V128	1.54	No	No	0	6	6
254	R:R:M209	R:R:S220	1.53	No	No	0	9	8
255	R:R:M221	R:R:S220	1.53	No	No	0	6	8
256	R:R:I78	R:R:T155	1.52	No	No	0	4	2
257	R:R:I181	R:R:T177	1.52	No	No	0	5	3
258	R:R:L121	R:R:V128	1.49	No	No	0	8	6
259	R:R:N176	R:R:S175	1.49	Yes	No	0	3	4
260	R:R:L185	R:R:V249	1.49	No	No	0	3	3
261	R:R:N24	R:R:V56	1.48	No	No	0	9	6
262	R:R:N65	R:R:V61	1.48	No	No	0	4	4
263	R:R:N86	R:R:V90	1.48	No	No	0	3	6
264	R:R:I240	R:R:I267	1.47	No	No	0	6	5
265	R:R:A183	R:R:H93	1.46	No	Yes	0	4	5
266	R:R:N161	R:R:T163	1.46	No	No	0	9	8
267	R:R:F263	R:R:P259	1.44	No	No	0	5	1
268	R:R:I117	R:R:L121	1.43	No	No	0	5	8
269	R:R:I147	R:R:N148	1.42	No	No	0	4	3
270	R:R:I147	R:R:N176	1.42	No	Yes	0	4	3
271	R:R:E70	R:R:T69	1.41	No	No	0	4	4
272	R:R:K287	R:R:L291	1.41	No	No	0	7	5
273	R:R:A68	R:R:F75	1.39	No	No	0	3	2
274	R:R:L116	R:R:L119	1.38	No	No	0	4	7
275	R:R:L134	R:R:L137	1.38	No	No	0	6	4
276	R:R:L116	R:R:N115	1.37	No	No	0	4	8
277	R:R:R124	R:R:S127	1.32	No	No	0	7	5
278	R:R:D218	R:R:Q217	1.31	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F9	8.1525	4	2	3
2	R:R:F17	4.7	4	5	5
3	R:R:N31	4.246	5	0	8
4	R:R:F43	10.034	5	6	6
5	R:R:D45	5.5075	4	0	8
6	R:R:R55	10.1267	6	3	9
7	R:R:W66	6.484	5	0	4
8	R:R:H93	8.91	5	0	5
9	R:R:W97	9.205	6	4	7
10	R:R:T100	4.44	4	4	8
11	R:R:F105	6.71	4	6	8
12	R:R:W164	5.2225	4	2	2
13	R:R:K165	6.08	5	2	4
14	R:R:R169	11.34	4	2	4
15	R:R:N176	4.735	4	0	3
16	R:R:N184	5.2725	4	1	5
17	R:R:P187	6.05	4	4	8
18	R:R:F195	5.905	4	0	7
19	R:R:F234	5.254	5	7	9
20	R:R:Y241	10.08	4	0	7
21	R:R:F261	7.744	5	0	1
22	R:R:Y271	11.734	5	3	6
23	R:R:H275	8.0675	4	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K165	R:R:R169	19.9734	3.71	Yes	Yes	2	4	4
2	R:R:F269	R:R:R169	43.2279	16.03	No	Yes	0	4	4
3	R:R:F269	R:R:I13	29.7957	7.54	No	No	0	4	4
4	R:R:I13	R:R:W66	28.1657	10.57	No	Yes	0	4	4
5	R:R:F269	R:R:L62	64.1738	4.87	No	No	0	4	4
6	R:R:L58	R:R:L62	62.6697	5.54	No	No	0	4	4
7	R:R:L58	R:R:P272	62.6277	3.28	No	No	0	4	8
8	R:R:P272	R:R:Y271	29.0541	5.56	No	Yes	3	8	6
9	R:R:Y241	R:R:Y271	13.0334	19.86	Yes	Yes	0	7	6
10	R:R:T274	R:R:Y241	14.1528	7.49	No	Yes	0	5	7
11	R:R:S270	R:R:T274	12.4318	3.2	No	No	0	5	5
12	R:R:S270	R:R:S273	10.6968	3.26	No	No	0	5	8
13	R:R:V56	R:R:W60	11.6762	8.58	No	No	0	6	1
14	R:R:N24	R:R:V56	16.2516	1.48	No	No	0	9	6
15	R:R:N24	R:R:R55	27.4451	6.03	No	Yes	0	9	9
16	R:R:P272	R:R:R55	33.5665	4.32	No	Yes	3	8	9
17	R:R:F26	R:R:T289	21.3236	3.89	No	No	0	8	6
18	R:R:T289	R:R:V30	12.5997	6.35	No	No	0	6	8
19	R:R:N31	R:R:V30	14.3767	4.43	Yes	No	0	8	8
20	R:R:D45	R:R:N31	31.4468	4.04	Yes	Yes	0	8	8
21	R:R:D45	R:R:I41	51.5391	5.6	Yes	No	0	8	6
22	R:R:I41	R:R:Q46	54.5614	4.12	No	No	0	6	6
23	R:R:F43	R:R:Q46	56.0515	3.51	Yes	No	0	6	6
24	R:R:F43	R:R:V129	68.7561	3.93	Yes	No	0	6	7
25	R:R:S101	R:R:V129	70.1483	3.23	No	No	0	5	7
26	R:R:L133	R:R:S101	71.4845	9.01	No	No	0	8	5
27	R:R:L133	R:R:L98	72.8068	6.92	No	No	0	8	7
28	R:R:F94	R:R:L98	75.4093	8.53	No	No	0	5	7
29	R:R:F94	R:R:L137	76.6895	4.87	No	No	0	5	4
30	R:R:H93	R:R:L137	79.2081	6.43	Yes	No	0	5	4
31	R:R:H93	R:R:W97	100	14.81	Yes	Yes	0	5	7
32	R:R:P187	R:R:W97	45.5856	12.16	Yes	Yes	4	8	7
33	R:R:N96	R:R:P187	62.9075	3.26	No	Yes	0	6	8
34	R:R:N92	R:R:N96	42.3324	6.81	No	No	0	8	6
35	R:R:N92	R:R:W88	40.9962	9.04	No	No	1	8	4
36	R:R:L62	R:R:W88	55.9396	4.56	No	No	0	4	4
37	R:R:K285	R:R:T289	12.3269	4.5	No	No	0	8	6
38	R:R:E34	R:R:K285	13.9079	10.8	No	No	0	6	8
39	R:R:D45	R:R:E34	17.4549	6.5	Yes	No	0	8	6
40	R:R:F26	R:R:V293	14.1878	3.93	No	No	0	8	6
41	R:R:I27	R:R:N31	11.1585	4.25	No	Yes	0	9	8
42	R:R:H275	R:R:R55	31.1879	11.28	Yes	Yes	3	9	9
43	R:R:H275	R:R:Y271	18.7841	5.44	Yes	Yes	3	9	6
44	R:R:I91	R:R:L58	10.9347	2.85	No	No	0	5	4
45	R:R:L71	R:R:W66	14.9573	6.83	No	Yes	0	4	4
46	R:R:L71	R:R:Y67	13.6491	8.21	No	No	0	4	4
47	R:R:N72	R:R:Y67	12.7256	18.61	No	No	0	3	4
48	R:R:N76	R:R:Y158	12.047	2.33	No	No	0	3	1
49	R:R:N76	R:R:P73	11.5643	1.63	No	No	0	3	4
50	R:R:N72	R:R:P73	11.5293	1.63	No	No	0	3	4
51	R:R:R81	R:R:Y158	13.6631	10.29	No	No	0	3	1
52	R:R:R81	R:R:Y85	16.3705	9.26	No	No	0	3	2
53	R:R:H93	R:R:L140	38.3378	16.71	Yes	No	0	5	5
54	R:R:L140	R:R:V179	30.7821	2.98	No	No	0	5	4
55	R:R:V179	R:R:Y85	29.278	3.79	No	No	0	4	2
56	R:R:N176	R:R:Y85	14.0618	8.14	Yes	No	0	3	2
57	R:R:W88	R:R:Y173	15.2022	7.72	No	No	1	4	2
58	R:R:N184	R:R:N96	23.2405	4.09	Yes	No	0	5	6
59	R:R:L174	R:R:Y173	14.7055	9.38	No	No	1	1	2
60	R:R:P187	R:R:T100	17.5318	5.25	Yes	Yes	4	8	8
61	R:R:T100	R:R:T191	74.2899	4.71	Yes	No	0	8	8
62	R:R:S103	R:R:T191	73.5064	6.4	No	No	0	8	8
63	R:R:S103	R:R:S194	30.4463	6.52	No	No	0	8	8
64	R:R:F195	R:R:F234	67.308	5.36	Yes	Yes	0	7	9
65	R:R:F234	R:R:I278	66.1886	10.05	Yes	No	0	9	8
66	R:R:H275	R:R:I278	48.9086	3.98	Yes	No	0	9	8
67	R:R:L107	R:R:S194	17.4759	7.51	No	No	0	8	8
68	R:R:L107	R:R:L108	12.2919	4.15	No	No	0	8	7
69	R:R:L198	R:R:V231	31.4887	4.47	No	No	0	9	7
70	R:R:F195	R:R:V231	41.2831	3.93	Yes	No	0	7	7
71	R:R:F118	R:R:L108	10.5289	2.44	No	No	0	9	7
72	R:R:I104	R:R:V128	10.5359	1.54	No	No	0	6	6
73	R:R:I104	R:R:S194	12.2989	3.1	No	No	0	6	8
74	R:R:H143	R:R:T178	20.8619	6.85	No	No	0	6	3
75	R:R:T177	R:R:T178	22.5199	1.57	No	No	0	3	3
76	R:R:I181	R:R:T177	24.164	1.52	No	No	0	5	3
77	R:R:I181	R:R:T180	30.6003	3.04	No	No	0	5	2
78	R:R:L174	R:R:T180	12.8725	11.79	No	No	1	1	2
79	R:R:H143	R:R:V146	19.1899	5.54	No	No	0	6	3
80	R:R:K156	R:R:W154	12.3618	5.8	No	No	0	2	4
81	R:R:N150	R:R:W154	14.0898	2.26	No	No	0	1	4
82	R:R:N150	R:R:V146	17.5038	2.96	No	No	0	1	3
83	R:R:E159	R:R:K156	10.6198	2.7	No	No	0	5	2
84	R:R:E265	R:R:R169	14.2018	12.79	No	Yes	0	3	4
85	R:R:H224	R:R:L202	26.1928	9	No	No	0	9	9
86	R:R:L198	R:R:L202	27.8089	2.77	No	No	0	9	9
87	R:R:H205	R:R:H224	18.6092	9.55	No	No	0	9	9
88	R:R:M221	R:R:S220	12.5367	1.53	No	No	0	6	8
89	R:R:M209	R:R:S220	14.5725	1.53	No	No	0	9	8
90	R:R:H205	R:R:M209	16.6084	2.63	No	No	0	9	9
91	R:R:F234	R:R:S233	14.5236	3.96	Yes	No	7	9	8
92	R:R:S233	R:R:W281	12.5157	6.18	No	No	0	8	5
93	R:R:L237	R:R:Y241	17.315	10.55	No	Yes	0	7	7
94	R:R:I267	R:R:Y241	14.1528	2.42	No	Yes	0	5	7
95	R:R:I267	R:R:S244	10.6968	6.19	No	No	0	5	5
96	R:R:K287	R:R:W281	10.5569	5.8	No	No	0	7	5
97	R:R:V293	R:R:V297	10.8647	1.6	No	No	0	6	6
98	R:R:K165	R:R:W164	10.2071	3.48	Yes	Yes	2	4	2
99	R:R:E265	R:R:F261	10.1861	11.66	No	Yes	0	3	1
100	R:R:T100	R:R:W97	57.5206	4.85	Yes	Yes	4	8	7
101	R:R:F195	R:R:S103	65.8528	11.89	Yes	No	0	7	8
102	R:R:I278	R:R:L237	17.6787	8.56	No	No	0	8	7
103	R:R:N184	R:R:T180	19.2948	5.85	Yes	No	1	5	2

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 7XP5_nogp

PDB Summary
PDB	7XP5_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.15
Number of Linked Nodes	268
Number of Links	278
Number of Hubs	23
Number of Links mediated by Hubs	89
Number of Communities	7
Number of Nodes involved in Communities	28
Number of Links involved in Communities	32

Path Summary
Number Of Nodes in MetaPath	104
Number Of Links MetaPath	103
Number of Shortest Paths	36457
Length Of Smallest Path	3
Average Path Length	15.2915
Length of Longest Path	38
Minimum Path Strength	1.375
Average Path Strength	6.38961
Maximum Path Strength	17.645
Minimum Path Correlation	0.7
Average Path Correlation	0.935688
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	50.0518
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	26.8539
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • system process • nervous system process • response to stimulus • detection of chemical stimulus involved in sensory perception of bitter taste • detection of chemical stimulus involved in sensory perception of taste • detection of stimulus • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • response to chemical • detection of chemical stimulus • sensory perception of bitter taste • detection of stimulus involved in sensory perception • detection of chemical stimulus involved in sensory perception • carbohydrate metabolic process • catabolic process • glucan catabolic process • beta-glucan metabolic process • carbohydrate catabolic process • primary metabolic process • macromolecule catabolic process • polysaccharide metabolic process • glucan metabolic process • beta-glucan catabolic process • polysaccharide catabolic process • metabolic process • cellular process • cellulose catabolic process • macromolecule metabolic process • cellulose metabolic process • cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • cilium • ciliary membrane • plasma membrane bounded cell projection • cell projection • bounding membrane of organelle • organelle • plasma membrane region • organelle membrane • cell projection membrane
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • membrane-bounded organelle • cilium • ciliary membrane • plasma membrane bounded cell projection • cell projection • bounding membrane of organelle • organelle • plasma membrane region • organelle membrane • cell projection membrane • extracellular region • cell surface • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P59540
Sequence	>7XP5_nogp_Chain_R T F L P I I F S I L I V V T F V I G N F A N G F I A L V N S I E W F K R Q K I S F A D Q I L T A L A V S R V G L L W V L V L N W Y A T E L N P A F N S I E V R I T A Y N V W A V I N H F S N W L A T S L S I F Y L L K I A N F S N L I F L H L K R R V K S V V L V I L L G P L L F L V C H L F V I N M N Q I I W T K E Y E G N M T W K I K L R S A M Y L S N T T V T I L A N L V P F T L T L I S F L L L I C S L C K H L K K M Q L H G K G S Q D P S M K V H I K A L Q T V T S F L L L C A I Y F L S I I M S V W S F E S L E N K P V F M F C E A I A F S Y P S T H P F I L I W G N K K L K Q T F L S V L W H V R Y W V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XP6	T2	Sensory	Taste2	T2R46	Homo sapiens	Strychnine	-	chim(Gs-CtGt3)/β1/γ2	3.01	2022-10-12	10.1126/science.abo1633
	7XP6 (No Gprot)	T2	Sensory	Taste2	T2R46	Homo sapiens	Strychnine	-		3.01	2022-10-12	10.1126/science.abo1633
	7XP5	T2	Sensory	Taste2	T2R46	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3.08	2022-10-12	10.1126/science.abo1633
	7XP5 (No Gprot)	T2	Sensory	Taste2	T2R46	Homo sapiens	-	-		3.08	2022-10-12	10.1126/science.abo1633
	7XP4	T2	Sensory	Taste2	T2R46	Homo sapiens	-	-	chim(Gs-CtGt3)/β1/γ2	3.01	2022-10-12	10.1126/science.abo1633
	7XP4 (No Gprot)	T2	Sensory	Taste2	T2R46	Homo sapiens	-	-		3.01	2022-10-12	10.1126/science.abo1633

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