Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 5.9925404
2A:A:H41 5.4945106
3A:A:N50 6.8954129
4A:A:S51 2.85409
5A:A:L63 3.0225409
6A:A:F219 5.443336108
7A:A:F222 10.4725417
8A:A:Q227 6.7425419
9A:A:R232 6.04418
10A:A:K233 4.62333619
11A:A:W234 6.60667619
12A:A:F238 5.74125819
13A:A:V247 3.735407
14A:A:Y253 4.924508
15A:A:D272 5.0854118
16A:A:F273 5.44286749
17A:A:I276 2.94118
18A:A:W277 7.36667646
19A:A:W281 10.715615
20A:A:I288 3.6409
21A:A:L289 6.145449
22A:A:F290 5.3056139
23A:A:L291 3.9525448
24A:A:N292 3.204509
25A:A:Q294 4.5425446
26A:A:L297 3.604548
27A:A:F312 4.6975408
28A:A:F315 9.20754146
29A:A:T320 3.915441
30A:A:D323 5.4125444
31A:A:D331 9.215154
32A:A:V334 3.46754154
33A:A:Y339 5.90667643
34A:A:F340 6.4165147
35A:A:I341 3.1225408
36A:A:R342 6.9175444
37A:A:F345 7.28167648
38A:A:S349 4.3975447
39A:A:H357 6.65407
40A:A:Y358 3.20833684
41A:A:C359 4.0775445
42A:A:Y360 5.09688
43A:A:F363 9.36545
44A:A:N371 5.02754138
45A:A:F376 6.7175408
46A:A:D381 10.8425487
47A:A:K385 7.0175485
48A:A:L388 3.62408
49B:B:L7 6.624178
50B:B:R8 2.8375403
51B:B:L14 3.71408
52B:B:D27 6.7975408
53B:B:V40 3.7975403
54B:B:I43 3.0225403
55B:B:M45 3.818564
56B:B:R48 4.918537
57B:B:L51 6.9975439
58B:B:H54 9.934539
59B:B:K57 9.686519
60B:B:Y59 7.375618
61B:B:W63 7.03507
62B:B:L69 3.394535
63B:B:S72 5.73439
64B:B:K78 6.6325408
65B:B:L79 3.646537
66B:B:I80 6.222538
67B:B:I81 3.7125437
68B:B:W82 7.35625839
69B:B:D83 7.962538
70B:B:Y85 8.3825434
71B:B:N88 11.3175437
72B:B:K89 4.995639
73B:B:L95 4.7625438
74B:B:W99 8.05619
75B:B:M101 4.348519
76B:B:Y105 3.69736
77B:B:N110 9.3275454
78B:B:Y111 5.914554
79B:B:V112 3.64438
80B:B:L117 4.03143719
81B:B:I123 3.6325456
82B:B:Y124 6.174506
83B:B:L139 6.605459
84B:B:H142 6.38286759
85B:B:Y145 5.40857718
86B:B:R150 6.9675476
87B:B:F151 4.69667659
88B:B:L152 3.5175403
89B:B:D154 5.28456
90B:B:I157 4.07333657
91B:B:T159 4.942559
92B:B:D163 7.424559
93B:B:W169 8.39758
94B:B:F180 6.92667677
95B:B:H183 7.115679
96B:B:D186 5.476519
97B:B:V187 4.148579
98B:B:L190 3.06333675
99B:B:L192 3.8575475
100B:B:A193 3.4525414
101B:B:F199 5.925679
102B:B:V200 6.87416
103B:B:S201 4.6075479
104B:B:C204 5.6517
105B:B:D205 6.404579
106B:B:K209 7.91333676
107B:B:L210 4.382515
108B:B:W211 8.00571778
109B:B:Q220 5.768517
110B:B:F222 5.83518
111B:B:H225 7.25714719
112B:B:D228 7.652519
113B:B:I232 5.09418
114B:B:F234 5.6415
115B:B:F235 4.98286716
116B:B:P236 6.3775417
117B:B:F241 6.41143716
118B:B:T243 4.874518
119B:B:D246 4.1775419
120B:B:D247 8.82519
121B:B:T249 5.31416
122B:B:R251 5.64667618
123B:B:F253 6.97516
124B:B:D254 5.805409
125B:B:L255 5.26416
126B:B:R256 7.2425409
127B:B:Y264 5.95833615
128B:B:C271 4.61415
129B:B:F278 4.58667617
130B:B:R283 6.44571769
131B:B:L284 3.04565
132B:B:L285 3.942516
133B:B:L286 4.3375467
134B:B:Y289 5.39429717
135B:B:D290 6.955416
136B:B:C294 4.2425405
137B:B:N295 4.82516
138B:B:W297 5.5525418
139B:B:D298 9.35469
140B:B:L300 5.9466
141B:B:K301 4.864565
142B:B:H311 7.75569
143B:B:R314 10.5217618
144B:B:L318 3.544566
145B:B:V327 3.825466
146B:B:W332 11.5129719
147B:B:D333 9.11469
148B:B:F335 5.805404
149B:B:L336 4.0875437
150B:B:K337 5.7525466
151B:B:W339 6.92333669
152G:G:Y40 9.655416
153G:G:H44 5.4875406
154G:G:D48 6.48167609
155G:G:L51 5.078566
156G:G:N59 4.946539
157G:G:P60 5.7075439
158G:G:F61 4.47875838
159R:R:F9 7.124523
160R:R:F17 4.74195
161R:R:N31 3.97667698
162R:R:E34 8.18496
163R:R:F43 10.0345206
164R:R:D45 5.5075498
165R:R:I47 5.38754209
166R:R:L51 6.235429
167R:R:R55 10.1267629
168R:R:L58 3.34524
169R:R:L62 4.3275424
170R:R:W66 5.905624
171R:R:W88 4.745624
172R:R:N92 5.892528
173R:R:H93 7.93333625
174R:R:S95 5.1025428
175R:R:N96 4.285426
176R:R:W97 9.205627
177R:R:L98 5.795407
178R:R:T100 4.44428
179R:R:F105 5.8925208
180R:R:K109 4.81409
181R:R:L140 6.6525425
182R:R:L144 3.885405
183R:R:W164 5.2225422
184R:R:K165 6.08524
185R:R:R169 9.568524
186R:R:Y173 6.134522
187R:R:L174 7.235421
188R:R:N176 4.735403
189R:R:N184 4.762525
190R:R:P187 6.05428
191R:R:F188 5.5875427
192R:R:T191 4.6925408
193R:R:F195 5.282507
194R:R:H205 5.826589
195R:R:S233 4.11428
196R:R:F234 5.254529
197R:R:Y241 7.59833627
198R:R:F261 7.7445211
199R:R:F269 6.794524
200R:R:Y271 11.734526
201R:R:S273 2.855408
202R:R:H275 6.89529
203R:R:I278 6.4225428
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:F219 A:A:H41 22.13735.66YesYes1086
2A:A:F219 A:A:L43 22.58353.65YesNo087
3A:A:I245 A:A:L43 22.72434.28NoNo077
4A:A:F290 A:A:I245 23.08615.02YesNo097
5A:A:F290 A:A:V247 66.86112.62YesYes097
6A:A:S51 A:A:V247 33.49054.85YesYes097
7A:A:N50 A:A:S51 33.50722.98YesYes099
8A:A:D252 A:A:N50 33.48134.04NoYes1289
9A:A:D252 A:A:N264 33.52265.39NoNo089
10A:A:N264 A:A:Y311 33.52810.47NoNo096
11A:A:Y253 A:A:Y311 33.53882.98YesNo086
12A:A:L297 A:A:Y253 1003.52YesYes088
13A:A:I341 A:A:L297 98.9142.85YesYes088
14A:A:F345 A:A:I341 98.72452.51YesYes088
15A:A:F273 A:A:F345 98.75769.65YesYes498
16A:A:F246 A:A:F273 98.88952.14NoYes099
17A:A:F246 A:A:L46 43.44512.44NoNo098
18A:A:L44 A:A:L46 35.77484.15NoNo098
19A:A:F238 A:A:L44 35.745715.83YesNo099
20A:A:N292 A:A:V247 33.51384.43YesYes097
21A:A:K293 A:A:N292 67.23252.8NoYes099
22A:A:K293 A:A:L296 67.19417.05NoNo096
23A:A:E299 A:A:L296 67.19863.98NoNo066
24A:A:E299 A:A:K300 67.19186.75NoNo069
25A:A:K300 A:A:Y253 67.1855.97NoYes098
26A:A:F290 A:A:T364 33.417612.97YesNo1399
27A:A:N292 A:A:T364 33.76544.39YesNo099
28A:A:C237 A:A:F238 10.36282.79NoYes189
29A:A:C237 B:B:Y59 10.21445.38NoYes188
30B:B:S316 B:B:Y59 10.54472.54NoYes198
31B:B:C317 B:B:S316 10.5943.44NoNo079
32B:B:C317 B:B:M61 10.51644.86NoNo076
33B:B:M61 B:B:W63 10.44144.65NoYes067
34A:A:H41 A:A:I383 21.98866.63YesNo068
35A:A:I276 A:A:L282 15.29852.85YesNo089
36A:A:L282 A:A:N279 14.9816.87NoNo098
37A:A:N279 A:A:W281 14.91355.65NoYes085
38A:A:W234 B:B:L117 22.54493.42YesYes199
39A:A:Q227 B:B:Y145 22.95334.51YesYes198
40A:A:K233 B:B:Y145 67.27783.58YesYes198
41A:A:R231 A:A:W234 47.72195NoYes099
42A:A:D272 A:A:R231 47.74684.76YesNo089
43A:A:K233 B:B:D228 33.3528.3YesYes199
44A:A:K233 B:B:D246 33.46992.77YesYes199
45A:A:F290 A:A:I288 77.13393.77YesYes099
46A:A:W281 B:B:D290 14.659610.05YesYes156
47A:A:A378 A:A:I288 76.78374.87NoYes079
48A:A:A378 A:A:Y360 76.74014NoYes078
49A:A:D381 A:A:Y360 37.952613.79YesYes878
50A:A:Y360 R:R:M209 37.89852.39YesNo889
51A:A:D381 R:R:H205 37.93118.82YesYes879
52R:R:H205 R:R:M209 37.84972.63YesNo899
53A:A:I383 A:A:N387 21.93714.25NoNo087
54A:A:I384 R:R:H205 15.12032.65NoYes069
55A:A:I384 A:A:L388 15.01422.85NoYes068
56A:A:N387 R:R:K109 21.8862.8NoYes079
57A:A:L388 A:A:L393 14.6752.77YesNo087
58A:A:L393 R:R:Y106 14.56798.21NoNo079
59B:B:K209 B:B:T221 12.099.01YesNo067
60B:B:T221 G:G:E22 12.99755.64NoNo079
61G:G:E22 G:G:L19 24.83311.33NoNo099
62G:G:L15 G:G:L19 17.47612.77NoNo029
63B:B:R8 G:G:L15 16.55642.43YesNo032
64B:B:I18 G:G:E22 38.49778.2NoNo079
65B:B:I18 B:B:R22 39.40976.26NoNo076
66B:B:D258 B:B:R22 42.150110.72NoNo076
67B:B:D258 B:B:F222 43.02864.78NoYes178
68B:B:F222 B:B:F241 12.38348.57YesYes186
69B:B:F222 B:B:F253 37.12287.5YesYes186
70B:B:D228 B:B:S227 33.26392.94YesNo196
71B:B:D247 B:B:S227 66.27175.89YesNo196
72B:B:D247 B:B:H225 51.55883.78YesYes199
73B:B:D246 B:B:S227 33.24055.89YesNo196
74B:B:H225 B:B:T243 37.32256.85YesYes198
75B:B:F241 B:B:T243 20.05052.59YesYes168
76B:B:F253 B:B:T243 12.84327.78YesYes168
77B:B:D247 B:B:T249 14.01187.23YesYes196
78B:B:H225 B:B:R251 13.546411.28YesYes198
79B:B:R251 B:B:T249 13.54496.47YesYes186
80B:B:F253 B:B:R251 25.68614.28YesYes168
81B:B:C271 B:B:D290 15.03184.67YesYes156
82B:B:C271 B:B:Y289 14.59134.03YesYes157
83B:B:W297 B:B:Y289 13.53914.82YesYes187
84R:R:L102 R:R:Y106 21.6868.21NoNo099
85R:R:L102 R:R:L48 28.71862.77NoNo098
86R:R:L279 R:R:L48 28.50355.54NoNo098
87R:R:H275 R:R:L279 28.288611.57YesNo099
88R:R:H275 R:R:R55 19.911411.28YesYes299
89R:R:P272 R:R:R55 15.99374.32NoYes289
90R:R:L58 R:R:P272 41.77253.28YesNo248
91R:R:L58 R:R:L62 34.80395.54YesYes244
92R:R:F269 R:R:L62 33.93934.87YesYes244
93R:R:F269 R:R:R169 25.146416.03YesYes244
94R:R:K165 R:R:R169 11.43033.71YesYes244
95R:R:F105 R:R:K109 14.47637.44YesYes089
96R:R:F105 R:R:I47 12.17283.77YesYes2089
97R:R:H205 R:R:H224 60.59659.55YesNo099
98R:R:H224 R:R:L202 60.17739NoNo099
99R:R:L198 R:R:L202 59.63792.77NoNo099
100R:R:L198 R:R:V231 59.5514.47NoNo097
101R:R:F195 R:R:V231 59.45953.93YesNo077
102R:R:F195 R:R:F234 18.05485.36YesYes079
103R:R:F234 R:R:I278 16.308710.05YesYes298
104R:R:H275 R:R:I278 14.15243.98YesYes298
105R:R:H275 R:R:Y271 16.31955.44YesYes296
106R:R:P272 R:R:Y271 26.64835.56NoYes286
107R:R:F195 R:R:S103 21.433611.89YesNo078
108R:R:S103 R:R:T191 19.38246.4NoYes088
109R:R:F188 R:R:T191 19.37372.59YesYes078
110R:R:F188 R:R:Y271 10.883912.38YesYes276
111R:R:C238 R:R:F195 19.46312.79NoYes077
112R:R:C238 R:R:T191 19.35525.07NoYes078
113R:R:N92 R:R:N96 11.71546.81YesYes286
114R:R:N92 R:R:Y173 10.8988.14YesYes282
115R:R:F269 R:R:Y173 10.63763.09YesYes242
116R:R:T100 R:R:T191 19.15884.71YesYes088
117R:R:P187 R:R:T100 10.8785.25YesYes288
118R:R:N96 R:R:P187 10.44933.26YesYes268
119R:R:F269 R:R:I13 16.00177.54YesNo044
120R:R:I13 R:R:W66 14.858810.57NoYes044
121A:A:F238 B:B:L117 22.6832.44YesYes199
122A:A:Q227 A:A:W234 25.08286.57YesYes199
123B:B:W297 B:B:Y264 13.466612.54YesYes185
124B:B:L117 B:B:Y145 44.96672.34YesYes198
125A:A:D272 A:A:F246 55.42428.36YesNo089
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7XP5
Class T2
SubFamily Sensory
Type Taste2
SubType T2R46
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGt3)/Beta1/Gamma2
PDB Resolution 3.08
Date 2022-10-12
D.O.I. 10.1126/science.abo1633
Net Summary
Imin 2.14
Number of Linked Nodes 884
Number of Links 1140
Number of Hubs 203
Number of Links mediated by Hubs 734
Number of Communities 21
Number of Nodes involved in Communities 284
Number of Links involved in Communities 445
Path Summary
Number Of Nodes in MetaPath 126
Number Of Links MetaPath 125
Number of Shortest Paths 16260695
Length Of Smallest Path 3
Average Path Length 51.3743
Length of Longest Path 68
Minimum Path Strength 1.13
Average Path Strength 5.47255
Maximum Path Strength 22.21
Minimum Path Correlation 0.7
Average Path Correlation 0.997761
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 28.9934
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 60.9614
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • system process   • nervous system process   • response to stimulus   • detection of chemical stimulus involved in sensory perception of bitter taste   • detection of chemical stimulus involved in sensory perception of taste   • detection of stimulus   • sensory perception of chemical stimulus   • sensory perception   • sensory perception of taste   • response to chemical   • detection of chemical stimulus   • sensory perception of bitter taste   • detection of stimulus involved in sensory perception   • detection of chemical stimulus involved in sensory perception   • carbohydrate metabolic process   • catabolic process   • glucan catabolic process   • beta-glucan metabolic process   • carbohydrate catabolic process   • primary metabolic process   • macromolecule catabolic process   • polysaccharide metabolic process   • glucan metabolic process   • beta-glucan catabolic process   • polysaccharide catabolic process   • metabolic process   • cellular process   • cellulose catabolic process   • macromolecule metabolic process   • cellulose metabolic process   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • membrane-bounded organelle   • cilium   • ciliary membrane   • plasma membrane bounded cell projection   • cell projection   • bounding membrane of organelle   • organelle   • plasma membrane region   • organelle membrane   • cell projection membrane
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • membrane-bounded organelle   • cilium   • ciliary membrane   • plasma membrane bounded cell projection   • cell projection   • bounding membrane of organelle   • organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • extracellular region   • cell surface   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7XP5_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTQNVKFVF DAVTDIIIK 
ENLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XP5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XP5_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP59540
Sequence
>7XP5_Chain_R
TFLPIIFSI LIVVTFVIG NFANGFIAL VNSIEWFKR QKISFADQI 
LTALAVSRV GLLWVLVLN WYATELNPA FNSIEVRIT AYNVWAVIN 
HFSNWLATS LSIFYLLKI ANFSNLIFL HLKRRVKSV VLVILLGPL 
LFLVCHLFV INMNQIIWT KEYEGNMTW KIKLRSAMY LSNTTVTIL 
ANLVPFTLT LISFLLLIC SLCKHLKKM QLHGKGSQD PSMKVHIKA 
LQTVTSFLL LCAIYFLSI IMSVWSFES LENKPVFMF CEAIAFSYP 
STHPFILIW GNKKLKQTF LSVLWHVRY WV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XP6T2SensoryTaste2T2R46Homo sapiensStrychnine-chim(Gs-CtGt3)/β1/γ23.012022-10-1210.1126/science.abo1633
7XP6 (No Gprot) T2SensoryTaste2T2R46Homo sapiensStrychnine-3.012022-10-1210.1126/science.abo1633
7XP5T2SensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/β1/γ23.082022-10-1210.1126/science.abo1633
7XP5 (No Gprot) T2SensoryTaste2T2R46Homo sapiens--3.082022-10-1210.1126/science.abo1633
7XP4T2SensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/β1/γ23.012022-10-1210.1126/science.abo1633
7XP4 (No Gprot) T2SensoryTaste2T2R46Homo sapiens--3.012022-10-1210.1126/science.abo1633




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