Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F9 7.124523
2R:R:F17 4.74105
3R:R:N31 3.97667698
4R:R:E34 8.18496
5R:R:F43 10.0345116
6R:R:D45 5.5075498
7R:R:I47 5.38754119
8R:R:L51 6.235429
9R:R:R55 10.1267629
10R:R:L58 3.34524
11R:R:L62 4.3275424
12R:R:W66 5.905624
13R:R:W88 4.745624
14R:R:N92 5.892528
15R:R:H93 7.93333625
16R:R:S95 5.1025428
17R:R:N96 4.285426
18R:R:W97 9.205627
19R:R:L98 5.795407
20R:R:T100 4.44428
21R:R:F105 5.8925118
22R:R:K109 4.81409
23R:R:L140 6.6525425
24R:R:L144 3.885405
25R:R:W164 5.2225422
26R:R:K165 6.08524
27R:R:R169 9.568524
28R:R:Y173 6.134522
29R:R:L174 7.235421
30R:R:N176 4.735403
31R:R:N184 4.762525
32R:R:P187 6.05428
33R:R:F188 5.5875427
34R:R:T191 4.6925408
35R:R:F195 5.282507
36R:R:H205 5.826589
37R:R:S233 4.11428
38R:R:F234 5.254529
39R:R:Y241 7.59833627
40R:R:F261 7.7445121
41R:R:F269 6.794524
42R:R:Y271 11.734526
43R:R:S273 2.855408
44R:R:H275 6.89529
45R:R:I278 6.4225428
46A:A:Y37 5.9925404
47A:A:H41 5.4945146
48A:A:N50 6.8954169
49A:A:S51 2.85409
50A:A:L63 3.0225409
51A:A:F219 5.443336148
52A:A:F222 10.4725417
53A:A:Q227 6.7425419
54A:A:R232 6.04418
55A:A:K233 4.62333619
56A:A:W234 6.60667619
57A:A:F238 5.74125819
58A:A:V247 3.735407
59A:A:Y253 4.924508
60A:A:D272 5.0854158
61A:A:F273 5.44286749
62A:A:I276 2.94158
63A:A:W277 7.36667646
64A:A:W281 10.715615
65A:A:I288 3.6409
66A:A:L289 6.145449
67A:A:F290 5.3056179
68A:A:L291 3.9525448
69A:A:N292 3.204509
70A:A:Q294 4.5425446
71A:A:L297 3.604548
72A:A:F312 4.6975408
73A:A:F315 9.20754186
74A:A:T320 3.915441
75A:A:D323 5.4125444
76A:A:D331 9.215194
77A:A:V334 3.46754194
78A:A:Y339 5.90667643
79A:A:F340 6.4165187
80A:A:I341 3.1225408
81A:A:R342 6.9175444
82A:A:F345 7.28167648
83A:A:S349 4.3975447
84A:A:H357 6.65407
85A:A:Y358 3.20833684
86A:A:C359 4.0775445
87A:A:Y360 5.09688
88A:A:F363 9.36545
89A:A:N371 5.02754178
90A:A:F376 6.7175408
91A:A:D381 10.8425487
92A:A:K385 7.0175485
93A:A:L388 3.62408
94B:B:L7 6.624208
95B:B:R8 2.8375403
96B:B:L14 3.71408
97B:B:D27 6.7975408
98B:B:V40 3.7975403
99B:B:I43 3.0225403
100B:B:M45 3.818564
101B:B:R48 4.918537
102B:B:L51 6.9975439
103B:B:H54 9.934539
104B:B:K57 9.686519
105B:B:Y59 7.375618
106B:B:W63 7.03507
107B:B:L69 3.394535
108B:B:S72 5.73439
109B:B:K78 6.6325408
110B:B:L79 3.646537
111B:B:I80 6.222538
112B:B:I81 3.7125437
113B:B:W82 7.35625839
114B:B:D83 7.962538
115B:B:Y85 8.3825434
116B:B:N88 11.3175437
117B:B:K89 4.995639
118B:B:L95 4.7625438
119B:B:W99 8.05619
120B:B:M101 4.348519
121B:B:Y105 3.69736
122B:B:N110 9.3275454
123B:B:Y111 5.914554
124B:B:V112 3.64438
125B:B:L117 4.03143719
126B:B:I123 3.6325456
127B:B:Y124 6.174506
128B:B:L139 6.605459
129B:B:H142 6.38286759
130B:B:Y145 5.40857718
131B:B:R150 6.9675476
132B:B:F151 4.69667659
133B:B:L152 3.5175403
134B:B:D154 5.28456
135B:B:I157 4.07333657
136B:B:T159 4.942559
137B:B:D163 7.424559
138B:B:W169 8.39758
139B:B:F180 6.92667677
140B:B:H183 7.115679
141B:B:D186 5.476519
142B:B:V187 4.148579
143B:B:L190 3.06333675
144B:B:L192 3.8575475
145B:B:A193 3.4525414
146B:B:F199 5.925679
147B:B:V200 6.87416
148B:B:S201 4.6075479
149B:B:C204 5.6517
150B:B:D205 6.404579
151B:B:K209 7.91333676
152B:B:L210 4.382515
153B:B:W211 8.00571778
154B:B:Q220 5.768517
155B:B:F222 5.83518
156B:B:H225 7.25714719
157B:B:D228 7.652519
158B:B:I232 5.09418
159B:B:F234 5.6415
160B:B:F235 4.98286716
161B:B:P236 6.3775417
162B:B:F241 6.41143716
163B:B:T243 4.874518
164B:B:D246 4.1775419
165B:B:D247 8.82519
166B:B:T249 5.31416
167B:B:R251 5.64667618
168B:B:F253 6.97516
169B:B:D254 5.805409
170B:B:L255 5.26416
171B:B:R256 7.2425409
172B:B:Y264 5.95833615
173B:B:C271 4.61415
174B:B:F278 4.58667617
175B:B:R283 6.44571769
176B:B:L284 3.04565
177B:B:L285 3.942516
178B:B:L286 4.3375467
179B:B:Y289 5.39429717
180B:B:D290 6.955416
181B:B:C294 4.2425405
182B:B:N295 4.82516
183B:B:W297 5.5525418
184B:B:D298 9.35469
185B:B:L300 5.9466
186B:B:K301 4.864565
187B:B:H311 7.75569
188B:B:R314 10.5217618
189B:B:L318 3.544566
190B:B:V327 3.825466
191B:B:W332 11.5129719
192B:B:D333 9.11469
193B:B:F335 5.805404
194B:B:L336 4.0875437
195B:B:K337 5.7525466
196B:B:W339 6.92333669
197G:G:Y40 9.655416
198G:G:H44 5.4875406
199G:G:D48 6.48167609
200G:G:L51 5.078566
201G:G:N59 4.946539
202G:G:P60 5.7075439
203G:G:F61 4.47875838
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:K165 R:R:R169 17.59913.71YesYes244
2R:R:F269 R:R:R169 37.267916.03YesYes244
3R:R:I13 R:R:W66 15.528410.57NoYes044
4R:R:F269 R:R:I13 16.56367.54YesNo044
5R:R:P272 R:R:R55 19.21264.32NoYes289
6R:R:L58 R:R:P272 50.4393.28YesNo248
7R:R:L58 R:R:L62 44.12865.54YesYes244
8R:R:F269 R:R:L62 43.34974.87YesYes244
9R:R:N92 R:R:N96 14.5586.81YesYes286
10R:R:N92 R:R:Y173 13.81798.14YesYes282
11R:R:F269 R:R:Y173 13.58593.09YesYes242
12R:R:L102 R:R:L48 32.31122.77NoNo098
13R:R:L279 R:R:L48 32.11645.54NoNo098
14R:R:H275 R:R:L279 31.921811.57YesNo099
15R:R:H275 R:R:R55 22.759311.28YesYes299
16R:R:H275 R:R:Y271 19.50625.44YesYes296
17R:R:P272 R:R:Y271 32.01395.56NoYes286
18B:B:W297 B:B:Y264 13.880512.54YesYes185
19B:B:W297 B:B:Y289 13.95614.82YesYes187
20B:B:C271 B:B:Y289 15.02794.03YesYes157
21B:B:C271 B:B:D290 15.47644.67YesYes156
22A:A:W281 B:B:D290 15.149210.05YesYes156
23A:A:N279 A:A:W281 15.46835.65NoYes085
24A:A:L282 A:A:N279 15.53936.87NoNo098
25A:A:I276 A:A:L282 15.86652.85YesNo089
26A:A:F246 A:A:L46 45.07812.44NoNo098
27A:A:F246 A:A:F273 1002.14NoYes099
28A:A:F273 A:A:F345 1009.65YesYes498
29A:A:F345 A:A:I341 1002.51YesYes088
30A:A:I341 A:A:L297 1002.85YesYes088
31A:A:L297 A:A:Y253 1003.52YesYes088
32A:A:K300 A:A:Y253 69.8335.97NoYes098
33A:A:E299 A:A:K300 69.84256.75NoNo069
34A:A:E299 A:A:L296 69.8523.98NoNo066
35A:A:K293 A:A:L296 69.85457.05NoNo096
36A:A:K293 A:A:N292 69.89912.8NoYes099
37A:A:N292 A:A:V247 34.86844.43YesYes097
38A:A:F290 A:A:V247 69.59262.62YesYes097
39A:A:F290 A:A:I245 24.48225.02YesNo097
40A:A:I245 A:A:L43 24.15624.28NoNo077
41A:A:F219 A:A:L43 24.03063.65YesNo087
42A:A:F219 A:A:H41 23.6345.66YesYes1486
43A:A:H41 A:A:I383 23.5016.63YesNo068
44A:A:I383 A:A:N387 23.45484.25NoNo087
45A:A:N387 R:R:K109 23.40892.8NoYes079
46R:R:F105 R:R:K109 15.12547.44YesYes089
47R:R:F105 R:R:I47 13.03983.77YesYes1189
48B:B:S84 B:B:W63 10.24247.41NoYes057
49B:B:M61 B:B:W63 10.74924.65NoYes067
50B:B:C317 B:B:M61 10.82714.86NoNo076
51B:B:C317 B:B:S316 10.90733.44NoNo079
52B:B:S316 B:B:Y59 10.86762.54NoYes198
53A:A:C237 B:B:Y59 10.58835.38NoYes188
54A:A:C237 A:A:F238 10.74252.79NoYes189
55A:A:F238 A:A:L44 37.084615.83YesNo099
56A:A:L44 A:A:L46 37.11594.15NoNo098
57A:A:D272 A:A:F246 57.50748.36YesNo089
58A:A:Y253 A:A:Y311 34.8682.98YesNo086
59A:A:N254 A:A:Y311 34.861410.47NoNo096
60A:A:D252 A:A:N254 34.85825.39NoNo089
61A:A:D252 A:A:N50 34.82254.04NoYes1689
62A:A:N50 A:A:S51 34.85412.98YesYes099
63A:A:S51 A:A:V247 34.8444.85YesYes097
64A:A:N292 A:A:T364 35.09624.39YesNo099
65A:A:F290 A:A:T364 34.782812.97YesNo1799
66A:A:F290 A:A:I288 79.84493.77YesYes099
67A:A:A378 A:A:I288 79.53874.87NoYes079
68A:A:A378 A:A:Y360 79.50044NoYes078
69A:A:Y360 R:R:M209 39.3312.39YesNo889
70R:R:H205 R:R:M209 39.28742.63YesNo899
71R:R:H205 R:R:H224 61.75969.55YesNo099
72R:R:H224 R:R:L202 61.38169NoNo099
73R:R:L198 R:R:L202 60.89362.77NoNo099
74R:R:L198 R:R:V231 60.81524.47NoNo097
75R:R:F195 R:R:V231 60.73443.93YesNo077
76R:R:F195 R:R:S103 21.279711.89YesNo078
77R:R:S103 R:R:T191 19.42426.4NoYes088
78R:R:T100 R:R:T191 19.12324.71YesYes088
79R:R:P187 R:R:T100 13.00315.25YesYes288
80R:R:N96 R:R:P187 12.61543.26YesYes268
81A:A:D381 A:A:Y360 39.380113.79YesYes878
82A:A:D381 R:R:H205 39.37038.82YesYes879
83R:R:C238 R:R:F195 19.49512.79NoYes077
84R:R:C238 R:R:T191 19.39745.07NoYes078
85R:R:L102 R:R:Y106 24.36068.21NoNo099
86A:A:I384 R:R:H205 16.83992.65NoYes069
87A:A:I384 A:A:L388 16.74392.85NoYes068
88A:A:L388 A:A:L393 16.43722.77YesNo087
89A:A:L393 R:R:Y106 16.34028.21NoNo079
90R:R:F195 R:R:F234 19.50025.36YesYes079
91R:R:F234 R:R:I278 17.919610.05YesYes298
92R:R:H275 R:R:I278 15.96753.98YesYes298
93R:R:F188 R:R:T191 19.51212.59YesYes078
94R:R:F188 R:R:Y271 13.007912.38YesYes276
95R:R:K167 R:R:T163 10.35346.01NoNo048
96R:R:I166 R:R:K167 14.49471.45NoNo034
97R:R:E265 R:R:R169 14.49412.79NoYes034
98A:A:R231 A:A:W234 49.50635NoYes099
99A:A:D272 A:A:R231 49.53384.76YesNo089
100A:A:W234 B:B:L117 23.38543.42YesYes199
101A:A:F238 B:B:L117 23.51052.44YesYes199
102A:A:Q227 A:A:W234 26.01576.57YesYes199
103A:A:Q227 B:B:Y145 23.73054.51YesYes198
104B:B:L117 B:B:Y145 46.60972.34YesYes198
105A:A:K233 B:B:Y145 69.62493.58YesYes198
106A:A:K233 B:B:D228 34.51558.3YesYes199
107A:A:K233 B:B:D246 34.63712.77YesYes199
108B:B:R8 G:G:L15 17.13462.43YesNo032
109G:G:L15 G:G:L19 18.08642.77NoNo029
110G:G:E22 G:G:L19 25.70041.33NoNo099
111B:B:I18 G:G:E22 39.85948.2NoNo079
112B:B:I18 B:B:R22 40.80436.26NoNo076
113B:B:D258 B:B:R22 43.642810.72NoNo076
114B:B:D258 B:B:F222 44.55734.78NoYes178
115B:B:F222 B:B:F241 12.82038.57YesYes186
116B:B:F241 B:B:T243 20.74492.59YesYes168
117B:B:H225 B:B:T243 38.61676.85YesYes198
118B:B:D247 B:B:H225 53.35283.78YesYes199
119B:B:D247 B:B:S227 68.585.89YesNo196
120B:B:D228 B:B:S227 34.42092.94YesNo196
121B:B:F222 B:B:F253 38.43587.5YesYes186
122B:B:F253 B:B:T243 13.2967.78YesYes168
123B:B:F253 B:B:R251 26.59194.28YesYes168
124B:B:H225 B:B:R251 14.022111.28YesYes198
125B:B:R251 B:B:T249 14.02086.47YesYes186
126B:B:D247 B:B:T249 14.50317.23YesYes196
127B:B:D246 B:B:S227 34.39975.89YesNo196
128B:B:K209 B:B:T221 12.4959.01YesNo067
129B:B:T221 G:G:E22 13.43595.64NoNo079
130R:R:K165 R:R:W164 12.42443.48YesYes242
131R:R:E265 R:R:F261 12.423411.66NoYes031
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7XP5
Class T
SubFamily Sensory
Type Taste2
SubType T2R46
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(Gs-CtGt3)/Beta1/Gamma2
PDB Resolution 3.08
Date 2022-10-12
D.O.I. 10.1126/science.abo1633
Net Summary
Imin 2.14
Number of Linked Nodes 885
Number of Links 1139
Number of Hubs 203
Number of Links mediated by Hubs 734
Number of Communities 21
Number of Nodes involved in Communities 284
Number of Links involved in Communities 445
Path Summary
Number Of Nodes in MetaPath 132
Number Of Links MetaPath 131
Number of Shortest Paths 18548849
Length Of Smallest Path 3
Average Path Length 57.8185
Length of Longest Path 66
Minimum Path Strength 1.13
Average Path Strength 6.36863
Maximum Path Strength 22.21
Minimum Path Correlation 0.7
Average Path Correlation 1
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.88679
Average % Of Corr. Nodes 32.0318
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 64.7777
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP59540
Sequence
>7XP5_Chain_R
TFLPIIFSI LIVVTFVIG NFANGFIAL VNSIEWFKR QKISFADQI 
LTALAVSRV GLLWVLVLN WYATELNPA FNSIEVRIT AYNVWAVIN 
HFSNWLATS LSIFYLLKI ANFSNLIFL HLKRRVKSV VLVILLGPL 
LFLVCHLFV INMNQIIWT KEYEGNMTW KIKLRSAMY LSNTTVTIL 
ANLVPFTLT LISFLLLIC SLCKHLKKM QLHGKGSQD PSMKVHIKA 
LQTVTSFLL LCAIYFLSI IMSVWSFES LENKPVFMF CEAIAFSYP 
STHPFILIW GNKKLKQTF LSVLWHVRY WV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7XP5_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNDFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTQNVKFVF DAVTDIIIK 
ENLKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7XP5_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7XP5_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7XP4TSensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/&β;1/&γ;23.012022-10-1210.1126/science.abo1633
7XP5TSensoryTaste2T2R46Homo sapiens--chim(Gs-CtGt3)/&β;1/&γ;23.082022-10-1210.1126/science.abo1633
7XP6TSensoryTaste2T2R46Homo sapiensStrychnine-chim(Gs-CtGt3)/&β;1/&γ;23.012022-10-1210.1126/science.abo1633




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