psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D2	L:L:L3	5.43	No	No	0	0	0
2	L:L:D2	L:L:Q4	3.92	No	No	0	0	0
3	L:L:Q4	N:N:Y11	9.02	No	No	0	0	0
4	L:L:C12	L:L:C7	7.28	No	No	0	0	0
5	L:L:C8	N:N:C7	7.28	No	No	0	0	0
6	L:L:D10	L:L:T9	7.23	No	No	0	0	0
7	L:L:D10	N:N:R5	3.57	No	No	0	0	0
8	L:L:G11	N:N:R5	6	No	No	0	0	0
9	L:L:C12	L:L:L17	3.17	No	Yes	0	0	0
10	L:L:D16	L:L:S13	8.83	No	No	0	0	0
11	L:L:M14	L:L:T15	3.01	No	No	0	0	0
12	L:L:L17	L:L:L20	4.15	Yes	No	0	0	0
13	L:L:S18	R:R:V277	3.23	No	No	0	0	1
14	L:L:C21	N:N:I18	9.82	No	No	0	0	0
15	L:L:C21	N:N:C19	5.46	No	No	0	0	0
16	N:N:C7	N:N:E10	4.56	No	No	0	0	0
17	N:N:V15	N:N:Y11	8.83	No	No	0	0	0
18	N:N:Y11	R:R:C186	4.03	No	No	0	0	2
19	N:N:I12	N:N:R13	2.51	No	Yes	0	0	0
20	N:N:I16	N:N:R13	2.51	No	Yes	4	0	0
21	N:N:R13	N:N:Y17	15.43	Yes	No	4	0	0
22	N:N:R13	R:R:D104	7.15	Yes	No	4	0	4
23	N:N:R13	R:R:F105	5.34	Yes	Yes	4	0	4
24	N:N:I16	N:N:V15	3.07	No	No	0	0	0
25	N:N:I16	R:R:F105	5.02	No	Yes	4	0	4
26	N:N:Y17	R:R:F105	9.28	No	Yes	4	0	4
27	N:N:Y17	R:R:T288	4.99	No	No	0	0	4
28	N:N:S21	R:R:Q287	4.33	No	No	0	0	3
29	N:N:S21	R:R:F291	6.61	No	Yes	0	0	4
30	N:N:R23	R:R:W97	10	No	Yes	0	0	7
31	N:N:R23	R:R:E100	9.3	No	Yes	0	0	5
32	N:N:W24	R:R:T121	12.13	Yes	No	0	0	6
33	N:N:W24	R:R:V122	2.45	Yes	Yes	1	0	4
34	N:N:W24	R:R:V125	3.68	Yes	No	0	0	7
35	N:N:W24	R:R:R208	22.99	Yes	No	0	0	5
36	N:N:W24	R:R:F291	3.01	Yes	Yes	1	0	4
37	N:N:W24	R:R:T295	2.43	Yes	No	1	0	6
38	N:N:W24	R:R:H299	7.41	Yes	No	0	0	7
39	R:R:F35	R:R:L36	13.4	No	No	0	3	3
40	R:R:L38	R:R:M41	4.24	No	No	0	4	4
41	R:R:L38	R:R:Y289	14.07	No	No	0	4	1
42	R:R:L40	R:R:R39	3.64	No	No	0	4	4
43	R:R:D104	R:R:R39	3.57	No	No	0	4	4
44	R:R:V42	R:R:Y46	5.05	Yes	Yes	1	5	8
45	R:R:V293	R:R:V42	3.21	No	Yes	0	5	5
46	R:R:C296	R:R:V42	3.42	No	Yes	1	4	5
47	R:R:A43	R:R:S101	3.42	No	No	0	6	4
48	R:R:A45	R:R:C296	3.61	No	No	0	4	4
49	R:R:L94	R:R:Y46	8.21	No	Yes	0	8	8
50	R:R:A98	R:R:Y46	4	No	Yes	0	6	8
51	R:R:T295	R:R:Y46	7.49	No	Yes	1	6	8
52	R:R:C296	R:R:Y46	8.06	No	Yes	1	4	8
53	R:R:C303	R:R:I52	6.55	No	No	0	6	5
54	R:R:G56	R:R:L55	5.13	No	No	0	8	4
55	R:R:D87	R:R:N57	16.16	Yes	No	6	9	9
56	R:R:L88	R:R:N57	10.98	No	No	0	7	9
57	R:R:N57	R:R:P306	6.52	No	No	6	9	9
58	R:R:L58	R:R:L88	4.15	No	No	0	2	7
59	R:R:L64	R:R:V60	2.98	Yes	Yes	0	7	9
60	R:R:A84	R:R:V60	3.39	No	Yes	0	8	9
61	R:R:F81	R:R:L61	3.65	No	No	0	6	6
62	R:R:T323	R:R:W62	8.49	No	No	8	4	3
63	R:R:F324	R:R:W62	7.02	Yes	No	8	6	3
64	R:R:A319	R:R:V63	3.39	No	No	0	5	7
65	R:R:D77	R:R:L64	5.43	No	Yes	7	7	7
66	R:R:L64	R:R:V80	2.98	Yes	No	7	7	8
67	R:R:G73	R:R:P74	4.06	No	No	0	6	7
68	R:R:D77	R:R:P74	9.66	No	No	0	7	7
69	R:R:D77	R:R:V80	2.92	No	No	7	7	8
70	R:R:F79	R:R:T78	2.59	Yes	Yes	2	7	6
71	R:R:R159	R:R:T78	11.64	No	Yes	2	4	6
72	R:R:T162	R:R:T78	7.85	Yes	Yes	2	6	6
73	R:R:A134	R:R:F79	2.77	No	Yes	0	7	7
74	R:R:F79	R:R:L135	3.65	Yes	Yes	2	7	8
75	R:R:A138	R:R:F79	4.16	No	Yes	0	8	7
76	R:R:F79	R:R:T162	7.78	Yes	Yes	2	7	6
77	R:R:F81	R:R:N82	3.62	No	Yes	0	6	9
78	R:R:L131	R:R:N82	2.75	No	Yes	0	8	9
79	R:R:N82	R:R:T162	5.85	Yes	Yes	0	9	6
80	R:R:N82	R:R:W166	4.52	Yes	Yes	0	9	9
81	R:R:D87	R:R:L83	2.71	Yes	No	0	9	9
82	R:R:L131	R:R:L83	4.15	No	No	0	8	9
83	R:R:L83	R:R:N305	13.73	No	No	0	9	9
84	R:R:A86	R:R:W166	2.59	No	Yes	0	8	9
85	R:R:D87	R:R:S302	2.94	Yes	No	0	9	8
86	R:R:D87	R:R:P306	3.22	Yes	No	6	9	9
87	R:R:G89	R:R:L92	3.42	No	No	0	7	5
88	R:R:G89	R:R:N124	5.09	No	No	0	7	8
89	R:R:L90	R:R:N124	8.24	No	No	0	7	8
90	R:R:H299	R:R:L90	9	No	No	0	7	7
91	R:R:L90	R:R:S302	7.51	No	No	0	7	8
92	R:R:L92	R:R:T93	2.95	No	No	0	5	6
93	R:R:A120	R:R:T93	5.03	No	No	0	4	6
94	R:R:L94	R:R:P95	3.28	No	No	0	8	9
95	R:R:F96	R:R:W107	3.01	No	Yes	3	6	9
96	R:R:F96	R:R:L113	6.09	No	No	0	6	6
97	R:R:F96	R:R:V117	5.24	No	No	3	6	5
98	R:R:W107	R:R:W97	4.69	Yes	Yes	3	9	7
99	R:R:V117	R:R:W97	4.9	No	Yes	3	5	7
100	R:R:L118	R:R:W97	6.83	No	Yes	0	5	7
101	R:R:T121	R:R:W97	4.85	No	Yes	0	6	7
102	R:R:E100	R:R:L103	2.65	Yes	No	0	5	4
103	R:R:E100	R:R:F105	2.33	Yes	Yes	0	5	4
104	R:R:E100	R:R:W107	17.45	Yes	Yes	0	5	9
105	R:R:D104	R:R:F105	4.78	No	Yes	4	4	4
106	R:R:F105	R:R:L190	7.31	Yes	Yes	0	4	3
107	R:R:H106	R:R:V188	11.07	No	No	0	4	3
108	R:R:F109	R:R:W107	9.02	No	Yes	0	7	9
109	R:R:C114	R:R:W107	13.06	No	Yes	3	9	9
110	R:R:V117	R:R:W107	4.9	No	Yes	3	5	9
111	R:R:R189	R:R:W107	5	Yes	Yes	3	4	9
112	R:R:C191	R:R:W107	13.06	No	Yes	3	9	9
113	R:R:F109	R:R:P108	5.78	No	No	0	7	3
114	R:R:F109	R:R:L113	6.09	No	No	0	7	6
115	R:R:G110	R:R:R189	4.5	No	Yes	0	8	4
116	R:R:G111	R:R:R189	3	No	Yes	0	3	4
117	R:R:C114	R:R:R189	6.96	No	Yes	3	9	4
118	R:R:C114	R:R:C191	7.28	No	No	3	9	9
119	R:R:G180	R:R:K115	5.23	No	No	0	5	7
120	R:R:K115	R:R:V181	4.55	No	No	0	7	4
121	R:R:A177	R:R:T119	5.03	No	No	0	4	6
122	R:R:V122	R:R:Y126	2.52	Yes	Yes	1	4	7
123	R:R:T173	R:R:V122	3.17	Yes	Yes	1	7	4
124	R:R:T176	R:R:V122	9.52	No	Yes	1	4	4
125	R:R:V122	R:R:Y204	3.79	Yes	Yes	1	4	5
126	R:R:L123	R:R:W166	3.42	No	Yes	0	5	9
127	R:R:L123	R:R:T173	8.84	No	Yes	0	5	7
128	R:R:V125	R:R:W259	3.68	No	Yes	0	7	9
129	R:R:F130	R:R:Y126	6.19	No	Yes	1	6	7
130	R:R:V172	R:R:Y126	6.31	No	Yes	1	4	7
131	R:R:T173	R:R:Y126	3.75	Yes	Yes	1	7	7
132	R:R:R208	R:R:Y126	3.09	No	Yes	0	5	7
133	R:R:L211	R:R:Y126	4.69	No	Yes	1	4	7
134	R:R:A127	R:R:W166	7.78	No	Yes	0	7	9
135	R:R:I129	R:R:P216	3.39	No	No	0	8	9
136	R:R:I129	R:R:W259	8.22	No	Yes	0	8	9
137	R:R:A169	R:R:F130	2.77	No	No	0	8	6
138	R:R:F130	R:R:L211	7.31	No	No	1	6	4
139	R:R:L131	R:R:V165	2.98	No	No	0	8	7
140	R:R:I132	R:R:I220	4.42	Yes	Yes	0	8	8
141	R:R:F255	R:R:I132	2.51	No	Yes	0	9	8
142	R:R:I132	R:R:N305	4.25	Yes	No	0	8	9
143	R:R:T133	R:R:V219	6.35	No	No	0	7	6
144	R:R:I220	R:R:T133	6.08	Yes	No	0	8	7
145	R:R:L135	R:R:R139	8.5	Yes	No	2	8	9
146	R:R:L135	R:R:Y309	8.21	Yes	Yes	2	8	9
147	R:R:I220	R:R:S136	7.74	Yes	No	2	8	9
148	R:R:S136	R:R:Y224	10.17	No	Yes	2	9	9
149	R:R:R139	R:R:Y224	5.14	No	Yes	2	9	9
150	R:R:R139	R:R:Y309	8.23	No	Yes	2	9	9
151	R:R:A144	R:R:Y140	9.34	No	No	0	7	7
152	R:R:L226	R:R:Y140	9.38	No	No	0	4	7
153	R:R:M145	R:R:W141	11.63	No	No	0	5	5
154	R:R:L153	R:R:W141	3.42	No	No	0	7	5
155	R:R:H152	R:R:V142	6.92	No	No	0	3	8
156	R:R:L153	R:R:V142	2.98	No	No	0	7	8
157	R:R:L227	R:R:V143	4.47	No	No	0	8	8
158	R:R:F230	R:R:V143	2.62	Yes	No	0	5	8
159	R:R:A144	R:R:F230	2.77	No	Yes	0	7	5
160	R:R:A146	R:R:H152	5.85	No	No	0	8	3
161	R:R:G148	R:R:P149	4.06	No	No	0	5	5
162	R:R:G148	R:R:H152	4.77	No	No	0	5	3
163	R:R:A158	R:R:L153	3.15	No	No	0	8	7
164	R:R:S154	R:R:W157	3.71	No	No	0	5	3
165	R:R:F156	R:R:W157	6.01	No	No	0	4	3
166	R:R:F156	R:R:I160	7.54	No	No	0	4	3
167	R:R:R159	R:R:T162	2.59	No	Yes	2	4	6
168	R:R:L211	R:R:V172	4.47	No	No	1	4	4
169	R:R:P175	R:R:V174	5.3	No	No	0	9	4
170	R:R:P175	R:R:Y204	6.95	No	Yes	0	9	5
171	R:R:T176	R:R:Y204	8.74	No	Yes	1	4	5
172	R:R:F179	R:R:V178	5.24	No	No	0	4	4
173	R:R:F179	R:R:F195	17.15	No	No	0	4	4
174	R:R:F179	R:R:W200	14.03	No	No	0	4	2
175	R:R:F195	R:R:V181	6.55	No	No	0	4	4
176	R:R:E182	R:R:R189	6.98	No	Yes	0	4	4
177	R:R:E184	R:R:G187	4.91	No	No	0	2	5
178	R:R:C191	R:R:R189	8.36	No	Yes	3	9	4
179	R:R:L193	R:R:L201	2.77	No	No	0	5	4
180	R:R:F195	R:R:P196	4.33	No	No	0	4	5
181	R:R:P196	R:R:Y199	6.95	No	No	11	5	1
182	R:R:P196	R:R:W200	5.4	No	No	11	5	2
183	R:R:R198	R:R:S197	2.64	No	No	0	2	2
184	R:R:K273	R:R:S197	3.06	No	No	0	3	2
185	R:R:W200	R:R:Y199	2.89	No	No	11	2	1
186	R:R:K273	R:R:L201	2.82	No	No	0	3	4
187	R:R:Q205	R:R:Y204	4.51	No	Yes	0	5	5
188	R:R:Q207	R:R:Y204	7.89	No	Yes	0	2	5
189	R:R:Q205	R:R:T266	7.09	No	No	0	5	5
190	R:R:Q205	R:R:V270	4.3	No	Yes	0	5	6
191	R:R:L206	R:R:V270	4.47	No	Yes	0	4	6
192	R:R:H263	R:R:V209	5.54	Yes	No	0	8	5
193	R:R:M214	R:R:V210	3.04	No	No	0	4	5
194	R:R:A212	R:R:H263	2.93	No	Yes	0	6	8
195	R:R:F213	R:R:M214	4.98	No	No	0	9	4
196	R:R:F213	R:R:F260	7.5	No	Yes	0	9	6
197	R:R:F213	R:R:H263	18.1	No	Yes	0	9	8
198	R:R:P216	R:R:V215	3.53	No	No	0	9	5
199	R:R:F255	R:R:L217	7.31	No	No	0	9	5
200	R:R:I220	R:R:Y224	2.42	Yes	Yes	2	8	9
201	R:R:L225	R:R:T221	2.95	No	No	0	3	4
202	R:R:L226	R:R:T222	2.95	No	No	0	4	4
203	R:R:V248	R:R:Y224	15.14	No	Yes	0	7	9
204	R:R:L251	R:R:Y224	4.69	No	Yes	0	8	9
205	R:R:L227	R:R:L231	2.77	No	Yes	0	8	8
206	R:R:A245	R:R:L228	3.15	No	No	0	5	4
207	R:R:L228	R:R:V248	4.47	No	No	0	4	7
208	R:R:F230	R:R:L231	2.44	Yes	Yes	0	5	8
209	R:R:F230	R:R:R234	9.62	Yes	No	10	5	5
210	R:R:L231	R:R:S241	4.5	Yes	No	0	8	7
211	R:R:L231	R:R:V244	4.47	Yes	No	0	8	7
212	R:R:Q232	R:R:R238	3.5	No	No	0	4	3
213	R:R:Q232	R:R:S241	4.33	No	No	0	4	7
214	R:R:R234	R:R:R237	5.33	No	No	0	5	3
215	R:R:D240	R:R:R237	8.34	No	No	0	5	3
216	R:R:I250	R:R:L308	2.85	No	Yes	0	5	8
217	R:R:L251	R:R:L308	4.15	No	Yes	0	8	8
218	R:R:L251	R:R:Y309	9.38	No	Yes	0	8	9
219	R:R:L304	R:R:S254	3	No	No	12	6	6
220	R:R:L308	R:R:S254	3	Yes	No	12	8	6
221	R:R:F255	R:R:W259	6.01	No	Yes	0	9	9
222	R:R:F256	R:R:F260	16.08	No	Yes	0	5	6
223	R:R:C258	R:R:W259	5.22	No	Yes	9	7	9
224	R:R:C258	R:R:N301	9.45	No	No	9	7	9
225	R:R:H263	R:R:W259	8.46	Yes	Yes	0	8	9
226	R:R:A298	R:R:W259	2.59	No	Yes	0	8	9
227	R:R:N301	R:R:W259	6.78	No	Yes	9	9	9
228	R:R:F260	R:R:P261	7.22	Yes	No	0	6	9
229	R:R:F260	R:R:V264	6.55	Yes	No	0	6	5
230	R:R:P261	R:R:T294	3.5	No	No	5	9	7
231	R:R:L297	R:R:P261	3.28	No	No	5	7	9
232	R:R:N262	R:R:T294	10.24	No	No	5	7	7
233	R:R:L297	R:R:N262	4.12	No	No	5	7	7
234	R:R:A298	R:R:N262	6.25	No	No	0	8	7
235	R:R:F291	R:R:V265	2.62	Yes	No	0	4	4
236	R:R:L271	R:R:W268	9.11	No	Yes	0	4	4
237	R:R:V272	R:R:W268	3.68	No	Yes	0	3	4
238	R:R:F283	R:R:W268	12.03	Yes	Yes	0	1	4
239	R:R:K273	R:R:V270	6.07	No	Yes	0	3	6
240	R:R:F274	R:R:V270	3.93	No	Yes	0	3	6
241	R:R:D275	R:R:L271	10.86	No	No	0	1	4
242	R:R:V272	R:R:W279	7.36	No	Yes	0	3	1
243	R:R:D275	R:R:L276	5.43	No	No	0	1	1
244	R:R:L276	R:R:P278	4.93	No	No	0	1	3
245	R:R:V277	R:R:W279	11.03	No	Yes	0	1	1
246	R:R:W279	R:R:Y284	9.65	Yes	No	0	1	3
247	R:R:F283	R:R:T282	7.78	Yes	No	0	1	3
248	R:R:F283	R:R:I286	2.51	Yes	No	0	1	2
249	R:R:F283	R:R:Q287	5.86	Yes	No	0	1	3
250	R:R:I286	R:R:V290	9.22	No	No	0	2	5
251	R:R:T288	R:R:Y289	11.24	No	No	0	4	1
252	R:R:F291	R:R:P292	5.78	Yes	No	0	4	4
253	R:R:F291	R:R:T295	7.78	Yes	No	1	4	6
254	R:R:L297	R:R:T294	8.84	No	No	5	7	7
255	R:R:L304	R:R:L308	4.15	No	Yes	12	6	8
256	R:R:N305	R:R:Y309	6.98	No	Yes	0	9	9
257	R:R:L311	R:R:V307	8.94	No	No	0	6	6
258	R:R:C310	R:R:P316	3.77	No	No	0	7	7
259	R:R:P316	R:R:R313	17.29	No	No	0	7	8
260	R:R:R314	R:R:R317	10.66	No	No	0	5	9
261	R:R:Q318	R:R:R314	14.02	No	No	0	4	5
262	R:R:E315	R:R:P316	4.72	No	No	0	6	7
263	R:R:F324	R:R:L320	8.53	Yes	No	0	6	7
264	R:R:F324	R:R:T323	5.19	Yes	No	8	6	4
265	L:L:L17	R:R:W279	2.28	Yes	Yes	0	0	1
266	R:R:L85	R:R:W166	2.28	No	Yes	0	5	9
267	L:L:C12	L:L:G11	1.96	No	No	0	0	0
268	N:N:C7	N:N:G8	1.96	No	No	0	0	0
269	R:R:C303	R:R:G53	1.96	No	No	0	6	9
270	R:R:C186	R:R:G187	1.96	No	No	0	2	5
271	R:R:A91	R:R:G53	1.95	No	No	0	6	9
272	R:R:A59	R:R:G56	1.95	No	No	0	6	8
273	R:R:P74	R:R:P75	1.95	No	No	0	7	7
274	R:R:W141	R:R:W157	1.87	No	No	0	5	3
275	R:R:G50	R:R:V49	1.84	No	No	0	6	7
276	R:R:G202	R:R:V270	1.84	No	Yes	0	3	6
277	R:R:G218	R:R:T221	1.82	No	No	0	2	4
278	R:R:P306	R:R:V60	1.77	No	Yes	0	9	9
279	R:R:P75	R:R:T151	1.75	No	No	0	7	5
280	R:R:C303	R:R:V49	1.71	No	No	0	6	7
281	R:R:G50	R:R:L94	1.71	No	No	0	6	8
282	R:R:C310	R:R:V63	1.71	No	No	0	7	7
283	R:R:G180	R:R:L193	1.71	No	No	0	5	5
284	R:R:G218	R:R:L217	1.71	No	No	0	2	5
285	R:R:A158	R:R:T78	1.68	No	Yes	0	8	6
286	R:R:A170	R:R:T173	1.68	No	Yes	0	3	7
287	R:R:E182	R:R:G183	1.64	No	No	0	4	1
288	R:R:N280	R:R:P278	1.63	No	No	0	4	3
289	R:R:S101	R:R:V42	1.62	No	Yes	0	4	5
290	R:R:S300	R:R:V49	1.62	No	No	0	5	7
291	R:R:A51	R:R:I52	1.62	No	No	0	5	5
292	R:R:S223	R:R:V137	1.62	No	No	0	7	6
293	R:R:S223	R:R:V219	1.62	No	No	0	7	6
294	R:R:S247	R:R:V243	1.62	No	No	0	7	7
295	L:L:S13	L:L:T15	1.6	No	No	0	0	0
296	R:R:V243	R:R:V244	1.6	No	No	0	7	7
297	R:R:V244	R:R:V248	1.6	No	No	0	7	7
298	N:N:T14	N:N:V15	1.59	No	No	0	0	0
299	R:R:C310	R:R:L64	1.59	No	Yes	0	7	7
300	R:R:T221	R:R:V252	1.59	No	No	0	4	8
301	N:N:A20	R:R:L190	1.58	No	Yes	0	0	3
302	R:R:A102	R:R:L40	1.58	No	No	0	3	4
303	R:R:A45	R:R:L44	1.58	No	No	0	4	5
304	R:R:A91	R:R:L54	1.58	No	No	0	6	6
305	R:R:A59	R:R:L320	1.58	No	No	0	6	7
306	R:R:A99	R:R:L103	1.58	No	No	0	4	4
307	R:R:A158	R:R:L155	1.58	No	No	0	8	3
308	R:R:T119	R:R:T176	1.57	No	No	0	6	4
309	R:R:I132	R:R:S128	1.55	Yes	No	0	8	9
310	L:L:C7	N:N:E10	1.52	No	No	0	0	0
311	L:L:M14	R:R:V277	1.52	No	No	0	0	1
312	R:R:I286	R:R:T285	1.52	No	No	0	2	3
313	R:R:L135	R:R:S76	1.5	Yes	No	0	8	8
314	R:R:L311	R:R:V60	1.49	No	Yes	0	6	9
315	R:R:L320	R:R:V63	1.49	No	No	0	7	7
316	R:R:L190	R:R:V188	1.49	Yes	No	0	3	3
317	R:R:L267	R:R:V209	1.49	No	No	0	5	5
318	R:R:L308	R:R:V307	1.49	Yes	No	0	8	6
319	R:R:L163	R:R:T162	1.47	No	Yes	0	3	6
320	R:R:G47	R:R:Y46	1.45	No	Yes	0	5	8
321	L:L:L17	N:N:I18	1.43	Yes	No	0	0	0
322	N:N:I12	N:N:L9	1.43	No	No	0	0	0
323	R:R:L113	R:R:M116	1.41	No	No	0	6	4
324	R:R:G269	R:R:W268	1.41	No	Yes	0	4	4
325	R:R:A161	R:R:F79	1.39	No	Yes	0	5	7
326	R:R:L44	R:R:L48	1.38	No	No	0	5	5
327	R:R:L190	R:R:L192	1.38	Yes	No	0	3	3
328	R:R:A245	R:R:R242	1.38	No	No	0	5	4
329	R:R:R194	R:R:V181	1.31	No	No	0	4	4
330	R:R:S281	R:R:Y284	1.27	No	No	0	7	3
331	R:R:I250	R:R:R246	1.25	No	No	0	5	6
332	R:R:Q239	R:R:R236	1.17	No	No	0	3	3
333	R:R:Q239	R:R:R238	1.17	No	No	0	3	3
334	R:R:F230	R:R:R233	1.07	Yes	No	10	5	5
335	R:R:R233	R:R:R234	1.07	No	No	10	5	5
336	R:R:F324	R:R:R325	1.07	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L17	2.7575	4	0	0
2	N:N:R13	6.588	5	4	0
3	N:N:W24	7.72857	7	1	0
4	R:R:V42	3.325	4	1	5
5	R:R:Y46	5.71	6	1	8
6	R:R:V60	2.4075	4	0	9
7	R:R:L64	3.245	4	7	7
8	R:R:T78	5.94	4	2	6
9	R:R:F79	3.72333	6	2	7
10	R:R:N82	4.185	4	0	9
11	R:R:D87	6.2575	4	6	9
12	R:R:W97	6.254	5	3	7
13	R:R:E100	7.9325	4	0	5
14	R:R:F105	5.67667	6	4	4
15	R:R:W107	8.77375	8	3	9
16	R:R:V122	4.29	5	1	4
17	R:R:Y126	4.425	6	1	7
18	R:R:I132	3.1825	4	0	8
19	R:R:L135	5.465	4	2	8
20	R:R:T162	5.108	5	2	6
21	R:R:W166	4.118	5	0	9
22	R:R:T173	4.36	4	1	7
23	R:R:R189	5.8	6	3	4
24	R:R:L190	2.94	4	0	3
25	R:R:Y204	6.376	5	1	5
26	R:R:I220	5.165	4	2	8
27	R:R:Y224	7.512	5	2	9
28	R:R:F230	3.704	5	10	5
29	R:R:L231	3.545	4	0	8
30	R:R:W259	5.85143	7	9	9
31	R:R:F260	9.3375	4	0	6
32	R:R:H263	8.7575	4	0	8
33	R:R:W268	6.5575	4	0	4
34	R:R:V270	4.122	5	0	6
35	R:R:W279	7.58	4	0	1
36	R:R:F283	7.045	4	0	1
37	R:R:F291	5.16	5	1	4
38	R:R:L308	3.128	5	12	8
39	R:R:Y309	8.2	4	2	9
40	R:R:F324	5.4525	4	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C12	L:L:L17	15.0772	3.17	No	Yes	0	0	0
2	L:L:L17	R:R:W279	22.2466	2.28	Yes	Yes	0	0	1
3	R:R:V272	R:R:W279	34.7416	7.36	No	Yes	0	3	1
4	R:R:V272	R:R:W268	36.0841	3.68	No	Yes	0	3	4
5	R:R:F283	R:R:W268	45.2316	12.03	Yes	Yes	0	1	4
6	R:R:F283	R:R:Q287	51.497	5.86	Yes	No	0	1	3
7	N:N:S21	R:R:Q287	52.7232	4.33	No	No	0	0	3
8	N:N:S21	R:R:F291	53.9405	6.61	No	Yes	0	0	4
9	N:N:W24	R:R:F291	53.2155	3.01	Yes	Yes	1	0	4
10	N:N:W24	R:R:T121	100	12.13	Yes	No	0	0	6
11	R:R:T121	R:R:W97	99.1945	4.85	No	Yes	0	6	7
12	N:N:R23	R:R:W97	38.1293	10	No	Yes	0	0	7
13	N:N:R23	R:R:E100	37.0374	9.3	No	Yes	0	0	5
14	R:R:E100	R:R:F105	69.0356	2.33	Yes	Yes	0	5	4
15	N:N:I16	R:R:F105	25.3077	5.02	No	Yes	4	0	4
16	N:N:I16	N:N:V15	23.4146	3.07	No	No	0	0	0
17	N:N:V15	N:N:Y11	18.2591	8.83	No	No	0	0	0
18	R:R:W107	R:R:W97	54.7818	4.69	Yes	Yes	3	9	7
19	R:R:E100	R:R:W107	39.1452	17.45	Yes	Yes	0	5	9
20	N:N:Y17	R:R:F105	12.7232	9.28	No	Yes	4	0	4
21	R:R:D104	R:R:F105	10.2887	4.78	No	Yes	4	4	4
22	N:N:Y17	R:R:T288	10.593	4.99	No	No	0	0	4
23	N:N:W24	R:R:V122	67.053	2.45	Yes	Yes	1	0	4
24	N:N:W24	R:R:V125	72.2354	3.68	Yes	No	0	0	7
25	N:N:W24	R:R:T295	29.228	2.43	Yes	No	1	0	6
26	N:N:W24	R:R:H299	36.7151	7.41	Yes	No	0	0	7
27	R:R:T295	R:R:Y46	32.1906	7.49	No	Yes	1	6	8
28	R:R:L94	R:R:Y46	16.6346	8.21	No	Yes	0	8	8
29	R:R:G50	R:R:L94	13.6899	1.71	No	No	0	6	8
30	R:R:G50	R:R:V49	12.2041	1.84	No	No	0	6	7
31	R:R:H299	R:R:L90	35.8067	9	No	No	0	7	7
32	R:R:L90	R:R:S302	34.1687	7.51	No	No	0	7	8
33	R:R:D87	R:R:S302	33.9405	2.94	Yes	No	0	9	8
34	R:R:D87	R:R:P306	33.1036	3.22	Yes	No	6	9	9
35	R:R:P306	R:R:V60	32.1325	1.77	No	Yes	0	9	9
36	R:R:L64	R:R:V60	31.7521	2.98	Yes	Yes	0	7	9
37	R:R:C310	R:R:L64	21.6603	1.59	No	Yes	0	7	7
38	R:R:C310	R:R:V63	15.6545	1.71	No	No	0	7	7
39	R:R:L320	R:R:V63	12.5979	1.49	No	No	0	7	7
40	R:R:T173	R:R:V122	29.7964	3.17	Yes	Yes	1	7	4
41	R:R:L123	R:R:T173	29.5323	8.84	No	Yes	0	5	7
42	R:R:L123	R:R:W166	29.0445	3.42	No	Yes	0	5	9
43	R:R:N82	R:R:W166	27.3439	4.52	Yes	Yes	0	9	9
44	R:R:N82	R:R:T162	26.0774	5.85	Yes	Yes	0	9	6
45	R:R:T162	R:R:T78	16.026	7.85	Yes	Yes	2	6	6
46	R:R:V125	R:R:W259	71.5641	3.68	No	Yes	0	7	9
47	R:R:F255	R:R:W259	62.8149	6.01	No	Yes	0	9	9
48	R:R:F255	R:R:I132	60.0224	2.51	No	Yes	0	9	8
49	R:R:I132	R:R:N305	22.6673	4.25	Yes	No	0	8	9
50	R:R:N305	R:R:Y309	19.2168	6.98	No	Yes	0	9	9
51	R:R:D87	R:R:L83	18.6529	2.71	Yes	No	0	9	9
52	R:R:L131	R:R:L83	10.0738	4.15	No	No	0	8	9
53	R:R:F105	R:R:L190	12.9067	7.31	Yes	Yes	0	4	3
54	R:R:V122	R:R:Y204	36.7644	3.79	Yes	Yes	1	4	5
55	R:R:Q205	R:R:Y204	31.7968	4.51	No	Yes	0	5	5
56	R:R:Q205	R:R:V270	29.0848	4.3	No	Yes	0	5	6
57	R:R:K273	R:R:V270	23.5534	6.07	No	Yes	0	3	6
58	R:R:K273	R:R:L201	19.3108	2.82	No	No	0	3	4
59	R:R:L193	R:R:L201	17.8787	2.77	No	No	0	5	4
60	R:R:G180	R:R:L193	16.4377	1.71	No	No	0	5	5
61	R:R:G180	R:R:K115	14.9877	5.23	No	No	0	5	7
62	R:R:K115	R:R:V181	13.5288	4.55	No	No	0	7	4
63	R:R:I132	R:R:I220	42.5599	4.42	Yes	Yes	0	8	8
64	R:R:I220	R:R:Y224	37.1851	2.42	Yes	Yes	2	8	9
65	R:R:V248	R:R:Y224	39.1273	15.14	No	Yes	0	7	9
66	R:R:V244	R:R:V248	33.1842	1.6	No	No	0	7	7
67	R:R:L231	R:R:V244	28.7268	4.47	Yes	No	0	8	7
68	R:R:F230	R:R:L231	16.2452	2.44	Yes	Yes	0	5	8
69	R:R:A158	R:R:T78	20.1253	1.68	No	Yes	0	8	6
70	R:R:A158	R:R:L153	17.3417	3.15	No	No	0	8	7
71	R:R:F195	R:R:V181	10.584	6.55	No	No	0	4	4
72	R:R:H263	R:R:W259	16.6972	8.46	Yes	Yes	0	8	9
73	R:R:F213	R:R:H263	10.7541	18.1	No	Yes	0	9	8
74	R:R:L251	R:R:Y224	12.8709	4.69	No	Yes	0	8	9
75	R:R:L251	R:R:Y309	11.3045	9.38	No	Yes	0	8	9
76	R:R:L251	R:R:L308	17.8877	4.15	No	Yes	0	8	8
77	R:R:F79	R:R:L135	11.2732	3.65	Yes	Yes	2	7	8
78	R:R:L83	R:R:N305	14.3701	13.73	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S18	R:R:V277	3.23	0	No	No	0	1	0	1
N:N:Y11	R:R:C186	4.03	0	No	No	0	2	0	1
N:N:R13	R:R:D104	7.15	4	Yes	No	0	4	0	1
N:N:R13	R:R:F105	5.34	4	Yes	Yes	0	4	0	1
N:N:I16	R:R:F105	5.02	4	No	Yes	0	4	0	1
N:N:Y17	R:R:F105	9.28	4	No	Yes	0	4	0	1
N:N:Y17	R:R:T288	4.99	4	No	No	0	4	0	1
N:N:S21	R:R:Q287	4.33	0	No	No	0	3	0	1
N:N:S21	R:R:F291	6.61	0	No	Yes	0	4	0	1
N:N:R23	R:R:W97	10	0	No	Yes	0	7	0	1
N:N:R23	R:R:E100	9.3	0	No	Yes	0	5	0	1
N:N:W24	R:R:T121	12.13	1	Yes	No	0	6	0	1
N:N:W24	R:R:V122	2.45	1	Yes	Yes	0	4	0	1
N:N:W24	R:R:V125	3.68	1	Yes	No	0	7	0	1
N:N:W24	R:R:R208	22.99	1	Yes	No	0	5	0	1
N:N:W24	R:R:F291	3.01	1	Yes	Yes	0	4	0	1
N:N:W24	R:R:T295	2.43	1	Yes	No	0	6	0	1
N:N:W24	R:R:H299	7.41	1	Yes	No	0	7	0	1
R:R:D104	R:R:R39	3.57	4	No	No	4	4	1	2
R:R:T295	R:R:Y46	7.49	1	No	Yes	6	8	1	2
R:R:H299	R:R:L90	9	0	No	No	7	7	1	2
R:R:W107	R:R:W97	4.69	3	Yes	Yes	9	7	2	1
R:R:V117	R:R:W97	4.9	3	No	Yes	5	7	2	1
R:R:L118	R:R:W97	6.83	0	No	Yes	5	7	2	1
R:R:T121	R:R:W97	4.85	0	No	Yes	6	7	1	1
R:R:E100	R:R:L103	2.65	0	Yes	No	5	4	1	2
R:R:E100	R:R:F105	2.33	0	Yes	Yes	5	4	1	1
R:R:E100	R:R:W107	17.45	0	Yes	Yes	5	9	1	2
R:R:D104	R:R:F105	4.78	4	No	Yes	4	4	1	1
R:R:F105	R:R:L190	7.31	4	Yes	Yes	4	3	1	1
R:R:V117	R:R:W107	4.9	3	No	Yes	5	9	2	2
R:R:V122	R:R:Y126	2.52	1	Yes	Yes	4	7	1	2
R:R:T173	R:R:V122	3.17	1	Yes	Yes	7	4	2	1
R:R:T176	R:R:V122	9.52	1	No	Yes	4	4	2	1
R:R:V122	R:R:Y204	3.79	1	Yes	Yes	4	5	1	2
R:R:V125	R:R:W259	3.68	0	No	Yes	7	9	1	2
R:R:T173	R:R:Y126	3.75	1	Yes	Yes	7	7	2	2
R:R:R208	R:R:Y126	3.09	0	No	Yes	5	7	1	2
R:R:T176	R:R:Y204	8.74	1	No	Yes	4	5	2	2
R:R:F291	R:R:V265	2.62	1	Yes	No	4	4	1	2
R:R:V272	R:R:W279	7.36	0	No	Yes	3	1	2	1
R:R:V277	R:R:W279	11.03	0	No	Yes	1	1	1	1
R:R:W279	R:R:Y284	9.65	0	Yes	No	1	3	1	2
R:R:F283	R:R:Q287	5.86	0	Yes	No	1	3	2	1
R:R:T288	R:R:Y289	11.24	0	No	No	4	1	1	2
R:R:F291	R:R:P292	5.78	1	Yes	No	4	4	1	2
R:R:F291	R:R:T295	7.78	1	Yes	No	4	6	1	1
L:L:L17	R:R:W279	2.28	0	Yes	Yes	0	1	0	1
R:R:C186	R:R:G187	1.96	0	No	No	2	5	1	2
N:N:A20	R:R:L190	1.58	0	No	Yes	0	3	0	1
L:L:M14	R:R:V277	1.52	0	No	No	0	1	0	1
R:R:L190	R:R:V188	1.49	0	Yes	No	3	3	1	2
R:R:L190	R:R:L192	1.38	0	Yes	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YJ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.33
Number of Linked Nodes	300
Number of Links	336
Number of Hubs	40
Number of Links mediated by Hubs	164
Number of Communities	12
Number of Nodes involved in Communities	61
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	58628
Length Of Smallest Path	3
Average Path Length	13.3416
Length of Longest Path	28
Minimum Path Strength	1.17
Average Path Strength	5.48724
Maximum Path Strength	17.56
Minimum Path Correlation	0.7
Average Path Correlation	0.941645
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	56.145
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1014
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • positive regulation of feeding behavior • multicellular organismal process • positive regulation of biological process • feeding behavior • regulation of behavior • behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of feeding behavior • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • neuronal dense core vesicle • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • G-protein beta-subunit binding • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity
SCOP2	Domain Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• WD40 repeat-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU9
Sequence	>7YJ4_nogp_Chain_R F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D F H W P F G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M A A G P G T H L S L F W A R I A T L A V W A A A A L V T V P T A V F G V E G E V C G V R L C L L R F P S R Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R Q R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L V P W N S T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E P R Q A L A G T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YJ4	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-	Gi2/β1/γ2	3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YJ4 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-		3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-	Gi2/β1/γ2	3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-		3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-	Gi2/β1/γ2	2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-		2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	9KFK	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-	Gi2/β1/γ2	2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFK (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-		2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7

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