psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D2	L:L:L3	5.43	No	No	0	0	0
2	L:L:D2	L:L:Q4	3.92	No	No	0	0	0
3	L:L:Q4	M:M:Y11	9.02	No	No	0	0	0
4	L:L:C12	L:L:C7	7.28	No	No	0	0	0
5	L:L:C8	M:M:C7	7.28	No	No	0	0	0
6	L:L:D10	L:L:T9	7.23	No	No	0	0	0
7	L:L:D10	M:M:R5	3.57	No	No	0	0	0
8	L:L:G11	M:M:R5	6	No	No	0	0	0
9	L:L:C12	L:L:L17	3.17	No	Yes	0	0	0
10	L:L:D16	L:L:S13	8.83	No	No	0	0	0
11	L:L:M14	L:L:T15	3.01	No	No	0	0	0
12	L:L:L17	L:L:L20	4.15	Yes	No	0	0	0
13	L:L:S18	R:R:V277	3.23	No	No	0	0	1
14	L:L:C21	M:M:I18	9.82	No	No	0	0	0
15	L:L:C21	M:M:C19	5.46	No	No	0	0	0
16	M:M:C7	M:M:E10	4.56	No	No	0	0	0
17	M:M:V15	M:M:Y11	8.83	No	No	0	0	0
18	M:M:Y11	R:R:C186	4.03	No	No	0	0	2
19	M:M:I12	M:M:R13	2.51	No	Yes	0	0	0
20	M:M:I16	M:M:R13	2.51	No	Yes	4	0	0
21	M:M:R13	M:M:Y17	15.43	Yes	No	4	0	0
22	M:M:R13	R:R:D104	7.15	Yes	No	4	0	4
23	M:M:R13	R:R:F105	5.34	Yes	Yes	4	0	4
24	M:M:I16	M:M:V15	3.07	No	No	0	0	0
25	M:M:I16	R:R:F105	5.02	No	Yes	4	0	4
26	M:M:Y17	R:R:F105	9.28	No	Yes	4	0	4
27	M:M:Y17	R:R:T288	4.99	No	No	0	0	4
28	M:M:S21	R:R:Q287	4.33	No	No	0	0	3
29	M:M:S21	R:R:F291	6.61	No	Yes	0	0	4
30	M:M:R23	R:R:W97	10	No	Yes	0	0	7
31	M:M:R23	R:R:E100	9.3	No	Yes	0	0	5
32	M:M:W24	R:R:T121	12.13	Yes	No	0	0	6
33	M:M:W24	R:R:V122	2.45	Yes	Yes	1	0	4
34	M:M:W24	R:R:V125	3.68	Yes	No	0	0	7
35	M:M:W24	R:R:R208	22.99	Yes	No	0	0	5
36	M:M:W24	R:R:F291	3.01	Yes	Yes	1	0	4
37	M:M:W24	R:R:T295	2.43	Yes	No	1	0	6
38	M:M:W24	R:R:H299	7.41	Yes	No	0	0	7
39	R:R:F35	R:R:L36	13.4	No	No	0	3	3
40	R:R:L38	R:R:M41	4.24	No	No	0	4	4
41	R:R:L38	R:R:Y289	14.07	No	No	0	4	1
42	R:R:L40	R:R:R39	3.64	No	No	0	4	4
43	R:R:D104	R:R:R39	3.57	No	No	0	4	4
44	R:R:V42	R:R:Y46	5.05	Yes	Yes	1	5	8
45	R:R:V293	R:R:V42	3.21	No	Yes	0	5	5
46	R:R:C296	R:R:V42	3.42	No	Yes	1	4	5
47	R:R:A43	R:R:S101	3.42	No	No	0	6	4
48	R:R:A45	R:R:C296	3.61	No	No	0	4	4
49	R:R:L94	R:R:Y46	8.21	No	Yes	0	8	8
50	R:R:A98	R:R:Y46	4	No	Yes	0	6	8
51	R:R:T295	R:R:Y46	7.49	No	Yes	1	6	8
52	R:R:C296	R:R:Y46	8.06	No	Yes	1	4	8
53	R:R:C303	R:R:I52	6.55	No	No	0	6	5
54	R:R:G56	R:R:L55	5.13	No	No	0	8	4
55	R:R:D87	R:R:N57	16.16	Yes	No	6	9	9
56	R:R:L88	R:R:N57	10.98	No	No	0	7	9
57	R:R:N57	R:R:P306	6.52	No	No	6	9	9
58	R:R:L58	R:R:L88	4.15	No	No	0	2	7
59	R:R:L64	R:R:V60	2.98	Yes	Yes	0	7	9
60	R:R:A84	R:R:V60	3.39	No	Yes	0	8	9
61	R:R:F81	R:R:L61	3.65	No	No	0	6	6
62	R:R:T323	R:R:W62	8.49	No	No	8	4	3
63	R:R:F324	R:R:W62	7.02	Yes	No	8	6	3
64	R:R:A319	R:R:V63	3.39	No	No	0	5	7
65	R:R:D77	R:R:L64	5.43	No	Yes	7	7	7
66	R:R:L64	R:R:V80	2.98	Yes	No	7	7	8
67	R:R:G73	R:R:P74	4.06	No	No	0	6	7
68	R:R:D77	R:R:P74	9.66	No	No	0	7	7
69	R:R:D77	R:R:V80	2.92	No	No	7	7	8
70	R:R:F79	R:R:T78	2.59	Yes	Yes	2	7	6
71	R:R:R159	R:R:T78	11.64	No	Yes	2	4	6
72	R:R:T162	R:R:T78	7.85	Yes	Yes	2	6	6
73	R:R:A134	R:R:F79	2.77	No	Yes	0	7	7
74	R:R:F79	R:R:L135	3.65	Yes	Yes	2	7	8
75	R:R:A138	R:R:F79	4.16	No	Yes	0	8	7
76	R:R:F79	R:R:T162	7.78	Yes	Yes	2	7	6
77	R:R:F81	R:R:N82	3.62	No	Yes	0	6	9
78	R:R:L131	R:R:N82	2.75	No	Yes	0	8	9
79	R:R:N82	R:R:T162	5.85	Yes	Yes	0	9	6
80	R:R:N82	R:R:W166	4.52	Yes	Yes	0	9	9
81	R:R:D87	R:R:L83	2.71	Yes	No	0	9	9
82	R:R:L131	R:R:L83	4.15	No	No	0	8	9
83	R:R:L83	R:R:N305	13.73	No	No	0	9	9
84	R:R:A86	R:R:W166	2.59	No	Yes	0	8	9
85	R:R:D87	R:R:S302	2.94	Yes	No	0	9	8
86	R:R:D87	R:R:P306	3.22	Yes	No	6	9	9
87	R:R:G89	R:R:L92	3.42	No	No	0	7	5
88	R:R:G89	R:R:N124	5.09	No	No	0	7	8
89	R:R:L90	R:R:N124	8.24	No	No	0	7	8
90	R:R:H299	R:R:L90	9	No	No	0	7	7
91	R:R:L90	R:R:S302	7.51	No	No	0	7	8
92	R:R:L92	R:R:T93	2.95	No	No	0	5	6
93	R:R:A120	R:R:T93	5.03	No	No	0	4	6
94	R:R:L94	R:R:P95	3.28	No	No	0	8	9
95	R:R:F96	R:R:W107	3.01	No	Yes	3	6	9
96	R:R:F96	R:R:L113	6.09	No	No	0	6	6
97	R:R:F96	R:R:V117	5.24	No	No	3	6	5
98	R:R:W107	R:R:W97	4.69	Yes	Yes	3	9	7
99	R:R:V117	R:R:W97	4.9	No	Yes	3	5	7
100	R:R:L118	R:R:W97	6.83	No	Yes	0	5	7
101	R:R:T121	R:R:W97	4.85	No	Yes	0	6	7
102	R:R:E100	R:R:L103	2.65	Yes	No	0	5	4
103	R:R:E100	R:R:F105	2.33	Yes	Yes	0	5	4
104	R:R:E100	R:R:W107	17.45	Yes	Yes	0	5	9
105	R:R:D104	R:R:F105	4.78	No	Yes	4	4	4
106	R:R:F105	R:R:L190	7.31	Yes	Yes	0	4	3
107	R:R:H106	R:R:V188	11.07	No	No	0	4	3
108	R:R:F109	R:R:W107	9.02	No	Yes	0	7	9
109	R:R:C114	R:R:W107	13.06	No	Yes	3	9	9
110	R:R:V117	R:R:W107	4.9	No	Yes	3	5	9
111	R:R:R189	R:R:W107	5	Yes	Yes	3	4	9
112	R:R:C191	R:R:W107	13.06	No	Yes	3	9	9
113	R:R:F109	R:R:P108	5.78	No	No	0	7	3
114	R:R:F109	R:R:L113	6.09	No	No	0	7	6
115	R:R:G110	R:R:R189	4.5	No	Yes	0	8	4
116	R:R:G111	R:R:R189	3	No	Yes	0	3	4
117	R:R:C114	R:R:R189	6.96	No	Yes	3	9	4
118	R:R:C114	R:R:C191	7.28	No	No	3	9	9
119	R:R:G180	R:R:K115	5.23	No	No	0	5	7
120	R:R:K115	R:R:V181	4.55	No	No	0	7	4
121	R:R:A177	R:R:T119	5.03	No	No	0	4	6
122	R:R:V122	R:R:Y126	2.52	Yes	Yes	1	4	7
123	R:R:T173	R:R:V122	3.17	Yes	Yes	1	7	4
124	R:R:T176	R:R:V122	9.52	No	Yes	1	4	4
125	R:R:V122	R:R:Y204	3.79	Yes	Yes	1	4	5
126	R:R:L123	R:R:W166	3.42	No	Yes	0	5	9
127	R:R:L123	R:R:T173	8.84	No	Yes	0	5	7
128	R:R:V125	R:R:W259	3.68	No	Yes	0	7	9
129	R:R:F130	R:R:Y126	6.19	No	Yes	1	6	7
130	R:R:V172	R:R:Y126	6.31	No	Yes	1	4	7
131	R:R:T173	R:R:Y126	3.75	Yes	Yes	1	7	7
132	R:R:R208	R:R:Y126	3.09	No	Yes	0	5	7
133	R:R:L211	R:R:Y126	4.69	No	Yes	1	4	7
134	R:R:A127	R:R:W166	7.78	No	Yes	0	7	9
135	R:R:I129	R:R:P216	3.39	No	No	0	8	9
136	R:R:I129	R:R:W259	8.22	No	Yes	0	8	9
137	R:R:A169	R:R:F130	2.77	No	No	0	8	6
138	R:R:F130	R:R:L211	7.31	No	No	1	6	4
139	R:R:L131	R:R:V165	2.98	No	No	0	8	7
140	R:R:I132	R:R:I220	4.42	Yes	Yes	0	8	8
141	R:R:F255	R:R:I132	2.51	No	Yes	0	9	8
142	R:R:I132	R:R:N305	4.25	Yes	No	0	8	9
143	R:R:T133	R:R:V219	6.35	No	No	0	7	6
144	R:R:I220	R:R:T133	6.08	Yes	No	0	8	7
145	R:R:L135	R:R:R139	8.5	Yes	No	2	8	9
146	R:R:L135	R:R:Y309	8.21	Yes	Yes	2	8	9
147	R:R:I220	R:R:S136	7.74	Yes	No	2	8	9
148	R:R:S136	R:R:Y224	10.17	No	Yes	2	9	9
149	R:R:R139	R:R:Y224	5.14	No	Yes	2	9	9
150	R:R:R139	R:R:Y309	8.23	No	Yes	2	9	9
151	R:R:A144	R:R:Y140	9.34	No	No	0	7	7
152	R:R:L226	R:R:Y140	9.38	No	No	0	4	7
153	R:R:M145	R:R:W141	11.63	No	No	0	5	5
154	R:R:L153	R:R:W141	3.42	No	No	0	7	5
155	R:R:H152	R:R:V142	6.92	No	No	0	3	8
156	R:R:L153	R:R:V142	2.98	No	No	0	7	8
157	R:R:L227	R:R:V143	4.47	No	No	0	8	8
158	R:R:F230	R:R:V143	2.62	Yes	No	0	5	8
159	R:R:A144	R:R:F230	2.77	No	Yes	0	7	5
160	R:R:A146	R:R:H152	5.85	No	No	0	8	3
161	R:R:G148	R:R:P149	4.06	No	No	0	5	5
162	R:R:G148	R:R:H152	4.77	No	No	0	5	3
163	R:R:A158	R:R:L153	3.15	No	No	0	8	7
164	R:R:S154	R:R:W157	3.71	No	No	0	5	3
165	R:R:F156	R:R:W157	6.01	No	No	0	4	3
166	R:R:F156	R:R:I160	7.54	No	No	0	4	3
167	R:R:R159	R:R:T162	2.59	No	Yes	2	4	6
168	R:R:L211	R:R:V172	4.47	No	No	1	4	4
169	R:R:P175	R:R:V174	5.3	No	No	0	9	4
170	R:R:P175	R:R:Y204	6.95	No	Yes	0	9	5
171	R:R:T176	R:R:Y204	8.74	No	Yes	1	4	5
172	R:R:F179	R:R:V178	5.24	No	No	0	4	4
173	R:R:F179	R:R:F195	17.15	No	No	0	4	4
174	R:R:F179	R:R:W200	14.03	No	No	0	4	2
175	R:R:F195	R:R:V181	6.55	No	No	0	4	4
176	R:R:E182	R:R:R189	6.98	No	Yes	0	4	4
177	R:R:E184	R:R:G187	4.91	No	No	0	2	5
178	R:R:C191	R:R:R189	8.36	No	Yes	3	9	4
179	R:R:L193	R:R:L201	2.77	No	No	0	5	4
180	R:R:F195	R:R:P196	4.33	No	No	0	4	5
181	R:R:P196	R:R:Y199	6.95	No	No	11	5	1
182	R:R:P196	R:R:W200	5.4	No	No	11	5	2
183	R:R:R198	R:R:S197	2.64	No	No	0	2	2
184	R:R:K273	R:R:S197	3.06	No	No	0	3	2
185	R:R:W200	R:R:Y199	2.89	No	No	11	2	1
186	R:R:K273	R:R:L201	2.82	No	No	0	3	4
187	R:R:Q205	R:R:Y204	4.51	No	Yes	0	5	5
188	R:R:Q207	R:R:Y204	7.89	No	Yes	0	2	5
189	R:R:Q205	R:R:T266	7.09	No	No	0	5	5
190	R:R:Q205	R:R:V270	4.3	No	Yes	0	5	6
191	R:R:L206	R:R:V270	4.47	No	Yes	0	4	6
192	R:R:H263	R:R:V209	5.54	Yes	No	0	8	5
193	R:R:M214	R:R:V210	3.04	No	No	0	4	5
194	R:R:A212	R:R:H263	2.93	No	Yes	0	6	8
195	R:R:F213	R:R:M214	4.98	No	No	0	9	4
196	R:R:F213	R:R:F260	7.5	No	Yes	0	9	6
197	R:R:F213	R:R:H263	18.1	No	Yes	0	9	8
198	R:R:P216	R:R:V215	3.53	No	No	0	9	5
199	R:R:F255	R:R:L217	7.31	No	No	0	9	5
200	R:R:I220	R:R:Y224	2.42	Yes	Yes	2	8	9
201	R:R:L225	R:R:T221	2.95	No	No	0	3	4
202	R:R:L226	R:R:T222	2.95	No	No	0	4	4
203	R:R:V248	R:R:Y224	15.14	No	Yes	0	7	9
204	R:R:L251	R:R:Y224	4.69	No	Yes	0	8	9
205	R:R:L227	R:R:L231	2.77	No	Yes	0	8	8
206	R:R:A245	R:R:L228	3.15	No	No	0	5	4
207	R:R:L228	R:R:V248	4.47	No	No	0	4	7
208	R:R:F230	R:R:L231	2.44	Yes	Yes	0	5	8
209	R:R:F230	R:R:R234	9.62	Yes	No	10	5	5
210	R:R:L231	R:R:S241	4.5	Yes	No	0	8	7
211	R:R:L231	R:R:V244	4.47	Yes	No	0	8	7
212	R:R:Q232	R:R:R238	3.5	No	No	0	4	3
213	R:R:Q232	R:R:S241	4.33	No	No	0	4	7
214	R:R:R234	R:R:R237	5.33	No	No	0	5	3
215	R:R:D240	R:R:R237	8.34	No	No	0	5	3
216	R:R:I250	R:R:L308	2.85	No	Yes	0	5	8
217	R:R:L251	R:R:L308	4.15	No	Yes	0	8	8
218	R:R:L251	R:R:Y309	9.38	No	Yes	0	8	9
219	R:R:L304	R:R:S254	3	No	No	12	6	6
220	R:R:L308	R:R:S254	3	Yes	No	12	8	6
221	R:R:F255	R:R:W259	6.01	No	Yes	0	9	9
222	R:R:F256	R:R:F260	16.08	No	Yes	0	5	6
223	R:R:C258	R:R:W259	5.22	No	Yes	9	7	9
224	R:R:C258	R:R:N301	9.45	No	No	9	7	9
225	R:R:H263	R:R:W259	8.46	Yes	Yes	0	8	9
226	R:R:A298	R:R:W259	2.59	No	Yes	0	8	9
227	R:R:N301	R:R:W259	6.78	No	Yes	9	9	9
228	R:R:F260	R:R:P261	7.22	Yes	No	0	6	9
229	R:R:F260	R:R:V264	6.55	Yes	No	0	6	5
230	R:R:P261	R:R:T294	3.5	No	No	5	9	7
231	R:R:L297	R:R:P261	3.28	No	No	5	7	9
232	R:R:N262	R:R:T294	10.24	No	No	5	7	7
233	R:R:L297	R:R:N262	4.12	No	No	5	7	7
234	R:R:A298	R:R:N262	6.25	No	No	0	8	7
235	R:R:F291	R:R:V265	2.62	Yes	No	0	4	4
236	R:R:L271	R:R:W268	9.11	No	Yes	0	4	4
237	R:R:V272	R:R:W268	3.68	No	Yes	0	3	4
238	R:R:F283	R:R:W268	12.03	Yes	Yes	0	1	4
239	R:R:K273	R:R:V270	6.07	No	Yes	0	3	6
240	R:R:F274	R:R:V270	3.93	No	Yes	0	3	6
241	R:R:D275	R:R:L271	10.86	No	No	0	1	4
242	R:R:V272	R:R:W279	7.36	No	Yes	0	3	1
243	R:R:D275	R:R:L276	5.43	No	No	0	1	1
244	R:R:L276	R:R:P278	4.93	No	No	0	1	3
245	R:R:V277	R:R:W279	11.03	No	Yes	0	1	1
246	R:R:W279	R:R:Y284	9.65	Yes	No	0	1	3
247	R:R:F283	R:R:T282	7.78	Yes	No	0	1	3
248	R:R:F283	R:R:I286	2.51	Yes	No	0	1	2
249	R:R:F283	R:R:Q287	5.86	Yes	No	0	1	3
250	R:R:I286	R:R:V290	9.22	No	No	0	2	5
251	R:R:T288	R:R:Y289	11.24	No	No	0	4	1
252	R:R:F291	R:R:P292	5.78	Yes	No	0	4	4
253	R:R:F291	R:R:T295	7.78	Yes	No	1	4	6
254	R:R:L297	R:R:T294	8.84	No	No	5	7	7
255	R:R:L304	R:R:L308	4.15	No	Yes	12	6	8
256	R:R:N305	R:R:Y309	6.98	No	Yes	0	9	9
257	R:R:L311	R:R:V307	8.94	No	No	0	6	6
258	R:R:C310	R:R:P316	3.77	No	No	0	7	7
259	R:R:P316	R:R:R313	17.29	No	No	0	7	8
260	R:R:R314	R:R:R317	10.66	No	No	0	5	9
261	R:R:Q318	R:R:R314	14.02	No	No	0	4	5
262	R:R:E315	R:R:P316	4.72	No	No	0	6	7
263	R:R:F324	R:R:L320	8.53	Yes	No	0	6	7
264	R:R:F324	R:R:T323	5.19	Yes	No	8	6	4
265	L:L:L17	R:R:W279	2.28	Yes	Yes	0	0	1
266	R:R:L85	R:R:W166	2.28	No	Yes	0	5	9
267	L:L:C12	L:L:G11	1.96	No	No	0	0	0
268	M:M:C7	M:M:G8	1.96	No	No	0	0	0
269	R:R:C303	R:R:G53	1.96	No	No	0	6	9
270	R:R:C186	R:R:G187	1.96	No	No	0	2	5
271	R:R:A91	R:R:G53	1.95	No	No	0	6	9
272	R:R:A59	R:R:G56	1.95	No	No	0	6	8
273	R:R:P74	R:R:P75	1.95	No	No	0	7	7
274	R:R:W141	R:R:W157	1.87	No	No	0	5	3
275	R:R:G50	R:R:V49	1.84	No	No	0	6	7
276	R:R:G202	R:R:V270	1.84	No	Yes	0	3	6
277	R:R:G218	R:R:T221	1.82	No	No	0	2	4
278	R:R:P306	R:R:V60	1.77	No	Yes	0	9	9
279	R:R:P75	R:R:T151	1.75	No	No	0	7	5
280	R:R:C303	R:R:V49	1.71	No	No	0	6	7
281	R:R:G50	R:R:L94	1.71	No	No	0	6	8
282	R:R:C310	R:R:V63	1.71	No	No	0	7	7
283	R:R:G180	R:R:L193	1.71	No	No	0	5	5
284	R:R:G218	R:R:L217	1.71	No	No	0	2	5
285	R:R:A158	R:R:T78	1.68	No	Yes	0	8	6
286	R:R:A170	R:R:T173	1.68	No	Yes	0	3	7
287	R:R:E182	R:R:G183	1.64	No	No	0	4	1
288	R:R:N280	R:R:P278	1.63	No	No	0	4	3
289	R:R:S101	R:R:V42	1.62	No	Yes	0	4	5
290	R:R:S300	R:R:V49	1.62	No	No	0	5	7
291	R:R:A51	R:R:I52	1.62	No	No	0	5	5
292	R:R:S223	R:R:V137	1.62	No	No	0	7	6
293	R:R:S223	R:R:V219	1.62	No	No	0	7	6
294	R:R:S247	R:R:V243	1.62	No	No	0	7	7
295	L:L:S13	L:L:T15	1.6	No	No	0	0	0
296	R:R:V243	R:R:V244	1.6	No	No	0	7	7
297	R:R:V244	R:R:V248	1.6	No	No	0	7	7
298	M:M:T14	M:M:V15	1.59	No	No	0	0	0
299	R:R:C310	R:R:L64	1.59	No	Yes	0	7	7
300	R:R:T221	R:R:V252	1.59	No	No	0	4	8
301	M:M:A20	R:R:L190	1.58	No	Yes	0	0	3
302	R:R:A102	R:R:L40	1.58	No	No	0	3	4
303	R:R:A45	R:R:L44	1.58	No	No	0	4	5
304	R:R:A91	R:R:L54	1.58	No	No	0	6	6
305	R:R:A59	R:R:L320	1.58	No	No	0	6	7
306	R:R:A99	R:R:L103	1.58	No	No	0	4	4
307	R:R:A158	R:R:L155	1.58	No	No	0	8	3
308	R:R:T119	R:R:T176	1.57	No	No	0	6	4
309	R:R:I132	R:R:S128	1.55	Yes	No	0	8	9
310	L:L:C7	M:M:E10	1.52	No	No	0	0	0
311	L:L:M14	R:R:V277	1.52	No	No	0	0	1
312	R:R:I286	R:R:T285	1.52	No	No	0	2	3
313	R:R:L135	R:R:S76	1.5	Yes	No	0	8	8
314	R:R:L311	R:R:V60	1.49	No	Yes	0	6	9
315	R:R:L320	R:R:V63	1.49	No	No	0	7	7
316	R:R:L190	R:R:V188	1.49	Yes	No	0	3	3
317	R:R:L267	R:R:V209	1.49	No	No	0	5	5
318	R:R:L308	R:R:V307	1.49	Yes	No	0	8	6
319	R:R:L163	R:R:T162	1.47	No	Yes	0	3	6
320	R:R:G47	R:R:Y46	1.45	No	Yes	0	5	8
321	L:L:L17	M:M:I18	1.43	Yes	No	0	0	0
322	M:M:I12	M:M:L9	1.43	No	No	0	0	0
323	R:R:L113	R:R:M116	1.41	No	No	0	6	4
324	R:R:G269	R:R:W268	1.41	No	Yes	0	4	4
325	R:R:A161	R:R:F79	1.39	No	Yes	0	5	7
326	R:R:L44	R:R:L48	1.38	No	No	0	5	5
327	R:R:L190	R:R:L192	1.38	Yes	No	0	3	3
328	R:R:A245	R:R:R242	1.38	No	No	0	5	4
329	R:R:R194	R:R:V181	1.31	No	No	0	4	4
330	R:R:S281	R:R:Y284	1.27	No	No	0	7	3
331	R:R:I250	R:R:R246	1.25	No	No	0	5	6
332	R:R:Q239	R:R:R236	1.17	No	No	0	3	3
333	R:R:Q239	R:R:R238	1.17	No	No	0	3	3
334	R:R:F230	R:R:R233	1.07	Yes	No	10	5	5
335	R:R:R233	R:R:R234	1.07	No	No	10	5	5
336	R:R:F324	R:R:R325	1.07	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:L17	2.7575	4	0	0
2	M:M:R13	6.588	5	4	0
3	M:M:W24	7.72857	7	1	0
4	R:R:V42	3.325	4	1	5
5	R:R:Y46	5.71	6	1	8
6	R:R:V60	2.4075	4	0	9
7	R:R:L64	3.245	4	7	7
8	R:R:T78	5.94	4	2	6
9	R:R:F79	3.72333	6	2	7
10	R:R:N82	4.185	4	0	9
11	R:R:D87	6.2575	4	6	9
12	R:R:W97	6.254	5	3	7
13	R:R:E100	7.9325	4	0	5
14	R:R:F105	5.67667	6	4	4
15	R:R:W107	8.77375	8	3	9
16	R:R:V122	4.29	5	1	4
17	R:R:Y126	4.425	6	1	7
18	R:R:I132	3.1825	4	0	8
19	R:R:L135	5.465	4	2	8
20	R:R:T162	5.108	5	2	6
21	R:R:W166	4.118	5	0	9
22	R:R:T173	4.36	4	1	7
23	R:R:R189	5.8	6	3	4
24	R:R:L190	2.94	4	0	3
25	R:R:Y204	6.376	5	1	5
26	R:R:I220	5.165	4	2	8
27	R:R:Y224	7.512	5	2	9
28	R:R:F230	3.704	5	10	5
29	R:R:L231	3.545	4	0	8
30	R:R:W259	5.85143	7	9	9
31	R:R:F260	9.3375	4	0	6
32	R:R:H263	8.7575	4	0	8
33	R:R:W268	6.5575	4	0	4
34	R:R:V270	4.122	5	0	6
35	R:R:W279	7.58	4	0	1
36	R:R:F283	7.045	4	0	1
37	R:R:F291	5.16	5	1	4
38	R:R:L308	3.128	5	12	8
39	R:R:Y309	8.2	4	2	9
40	R:R:F324	5.4525	4	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:C12	L:L:L17	15.0772	3.17	No	Yes	0	0	0
2	L:L:L17	R:R:W279	22.2466	2.28	Yes	Yes	0	0	1
3	R:R:V272	R:R:W279	34.7416	7.36	No	Yes	0	3	1
4	R:R:V272	R:R:W268	36.0841	3.68	No	Yes	0	3	4
5	R:R:F283	R:R:W268	45.2316	12.03	Yes	Yes	0	1	4
6	R:R:F283	R:R:Q287	51.497	5.86	Yes	No	0	1	3
7	M:M:S21	R:R:Q287	52.7232	4.33	No	No	0	0	3
8	M:M:S21	R:R:F291	53.9405	6.61	No	Yes	0	0	4
9	M:M:W24	R:R:F291	53.2155	3.01	Yes	Yes	1	0	4
10	M:M:W24	R:R:T121	100	12.13	Yes	No	0	0	6
11	R:R:T121	R:R:W97	99.1945	4.85	No	Yes	0	6	7
12	M:M:R23	R:R:W97	38.1293	10	No	Yes	0	0	7
13	M:M:R23	R:R:E100	37.0374	9.3	No	Yes	0	0	5
14	R:R:E100	R:R:F105	69.0356	2.33	Yes	Yes	0	5	4
15	M:M:I16	R:R:F105	25.3077	5.02	No	Yes	4	0	4
16	M:M:I16	M:M:V15	23.4146	3.07	No	No	0	0	0
17	M:M:V15	M:M:Y11	18.2591	8.83	No	No	0	0	0
18	R:R:W107	R:R:W97	54.7818	4.69	Yes	Yes	3	9	7
19	R:R:E100	R:R:W107	39.1452	17.45	Yes	Yes	0	5	9
20	M:M:Y17	R:R:F105	12.7232	9.28	No	Yes	4	0	4
21	R:R:D104	R:R:F105	10.2887	4.78	No	Yes	4	4	4
22	M:M:Y17	R:R:T288	10.593	4.99	No	No	0	0	4
23	M:M:W24	R:R:V122	67.053	2.45	Yes	Yes	1	0	4
24	M:M:W24	R:R:V125	72.2354	3.68	Yes	No	0	0	7
25	M:M:W24	R:R:T295	29.228	2.43	Yes	No	1	0	6
26	M:M:W24	R:R:H299	36.7151	7.41	Yes	No	0	0	7
27	R:R:T295	R:R:Y46	32.1906	7.49	No	Yes	1	6	8
28	R:R:L94	R:R:Y46	16.6346	8.21	No	Yes	0	8	8
29	R:R:G50	R:R:L94	13.6899	1.71	No	No	0	6	8
30	R:R:G50	R:R:V49	12.2041	1.84	No	No	0	6	7
31	R:R:H299	R:R:L90	35.8067	9	No	No	0	7	7
32	R:R:L90	R:R:S302	34.1687	7.51	No	No	0	7	8
33	R:R:D87	R:R:S302	33.9405	2.94	Yes	No	0	9	8
34	R:R:D87	R:R:P306	33.1036	3.22	Yes	No	6	9	9
35	R:R:P306	R:R:V60	32.1325	1.77	No	Yes	0	9	9
36	R:R:L64	R:R:V60	31.7521	2.98	Yes	Yes	0	7	9
37	R:R:C310	R:R:L64	21.6603	1.59	No	Yes	0	7	7
38	R:R:C310	R:R:V63	15.6545	1.71	No	No	0	7	7
39	R:R:L320	R:R:V63	12.5979	1.49	No	No	0	7	7
40	R:R:T173	R:R:V122	29.7964	3.17	Yes	Yes	1	7	4
41	R:R:L123	R:R:T173	29.5323	8.84	No	Yes	0	5	7
42	R:R:L123	R:R:W166	29.0445	3.42	No	Yes	0	5	9
43	R:R:N82	R:R:W166	27.3439	4.52	Yes	Yes	0	9	9
44	R:R:N82	R:R:T162	26.0774	5.85	Yes	Yes	0	9	6
45	R:R:T162	R:R:T78	16.026	7.85	Yes	Yes	2	6	6
46	R:R:V125	R:R:W259	71.5641	3.68	No	Yes	0	7	9
47	R:R:F255	R:R:W259	62.8149	6.01	No	Yes	0	9	9
48	R:R:F255	R:R:I132	60.0224	2.51	No	Yes	0	9	8
49	R:R:I132	R:R:N305	22.6673	4.25	Yes	No	0	8	9
50	R:R:N305	R:R:Y309	19.2168	6.98	No	Yes	0	9	9
51	R:R:D87	R:R:L83	18.6529	2.71	Yes	No	0	9	9
52	R:R:L131	R:R:L83	10.0738	4.15	No	No	0	8	9
53	R:R:F105	R:R:L190	12.9067	7.31	Yes	Yes	0	4	3
54	R:R:V122	R:R:Y204	36.7644	3.79	Yes	Yes	1	4	5
55	R:R:Q205	R:R:Y204	31.7968	4.51	No	Yes	0	5	5
56	R:R:Q205	R:R:V270	29.0848	4.3	No	Yes	0	5	6
57	R:R:K273	R:R:V270	23.5534	6.07	No	Yes	0	3	6
58	R:R:K273	R:R:L201	19.3108	2.82	No	No	0	3	4
59	R:R:L193	R:R:L201	17.8787	2.77	No	No	0	5	4
60	R:R:G180	R:R:L193	16.4377	1.71	No	No	0	5	5
61	R:R:G180	R:R:K115	14.9877	5.23	No	No	0	5	7
62	R:R:K115	R:R:V181	13.5288	4.55	No	No	0	7	4
63	R:R:I132	R:R:I220	42.5599	4.42	Yes	Yes	0	8	8
64	R:R:I220	R:R:Y224	37.1851	2.42	Yes	Yes	2	8	9
65	R:R:V248	R:R:Y224	39.1273	15.14	No	Yes	0	7	9
66	R:R:V244	R:R:V248	33.1842	1.6	No	No	0	7	7
67	R:R:L231	R:R:V244	28.7268	4.47	Yes	No	0	8	7
68	R:R:F230	R:R:L231	16.2452	2.44	Yes	Yes	0	5	8
69	R:R:A158	R:R:T78	20.1253	1.68	No	Yes	0	8	6
70	R:R:A158	R:R:L153	17.3417	3.15	No	No	0	8	7
71	R:R:F195	R:R:V181	10.584	6.55	No	No	0	4	4
72	R:R:H263	R:R:W259	16.6972	8.46	Yes	Yes	0	8	9
73	R:R:F213	R:R:H263	10.7541	18.1	No	Yes	0	9	8
74	R:R:L251	R:R:Y224	12.8709	4.69	No	Yes	0	8	9
75	R:R:L251	R:R:Y309	11.3045	9.38	No	Yes	0	8	9
76	R:R:L251	R:R:L308	17.8877	4.15	No	Yes	0	8	8
77	R:R:F79	R:R:L135	11.2732	3.65	Yes	Yes	2	7	8
78	R:R:L83	R:R:N305	14.3701	13.73	No	No	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:S18	R:R:V277	3.23	0	No	No	0	1	0	1
M:M:Y11	R:R:C186	4.03	0	No	No	0	2	0	1
M:M:R13	R:R:D104	7.15	4	Yes	No	0	4	0	1
M:M:R13	R:R:F105	5.34	4	Yes	Yes	0	4	0	1
M:M:I16	R:R:F105	5.02	4	No	Yes	0	4	0	1
M:M:Y17	R:R:F105	9.28	4	No	Yes	0	4	0	1
M:M:Y17	R:R:T288	4.99	4	No	No	0	4	0	1
M:M:S21	R:R:Q287	4.33	0	No	No	0	3	0	1
M:M:S21	R:R:F291	6.61	0	No	Yes	0	4	0	1
M:M:R23	R:R:W97	10	0	No	Yes	0	7	0	1
M:M:R23	R:R:E100	9.3	0	No	Yes	0	5	0	1
M:M:W24	R:R:T121	12.13	1	Yes	No	0	6	0	1
M:M:W24	R:R:V122	2.45	1	Yes	Yes	0	4	0	1
M:M:W24	R:R:V125	3.68	1	Yes	No	0	7	0	1
M:M:W24	R:R:R208	22.99	1	Yes	No	0	5	0	1
M:M:W24	R:R:F291	3.01	1	Yes	Yes	0	4	0	1
M:M:W24	R:R:T295	2.43	1	Yes	No	0	6	0	1
M:M:W24	R:R:H299	7.41	1	Yes	No	0	7	0	1
R:R:D104	R:R:R39	3.57	4	No	No	4	4	1	2
R:R:T295	R:R:Y46	7.49	1	No	Yes	6	8	1	2
R:R:H299	R:R:L90	9	0	No	No	7	7	1	2
R:R:W107	R:R:W97	4.69	3	Yes	Yes	9	7	2	1
R:R:V117	R:R:W97	4.9	3	No	Yes	5	7	2	1
R:R:L118	R:R:W97	6.83	0	No	Yes	5	7	2	1
R:R:T121	R:R:W97	4.85	0	No	Yes	6	7	1	1
R:R:E100	R:R:L103	2.65	0	Yes	No	5	4	1	2
R:R:E100	R:R:F105	2.33	0	Yes	Yes	5	4	1	1
R:R:E100	R:R:W107	17.45	0	Yes	Yes	5	9	1	2
R:R:D104	R:R:F105	4.78	4	No	Yes	4	4	1	1
R:R:F105	R:R:L190	7.31	4	Yes	Yes	4	3	1	1
R:R:V117	R:R:W107	4.9	3	No	Yes	5	9	2	2
R:R:V122	R:R:Y126	2.52	1	Yes	Yes	4	7	1	2
R:R:T173	R:R:V122	3.17	1	Yes	Yes	7	4	2	1
R:R:T176	R:R:V122	9.52	1	No	Yes	4	4	2	1
R:R:V122	R:R:Y204	3.79	1	Yes	Yes	4	5	1	2
R:R:V125	R:R:W259	3.68	0	No	Yes	7	9	1	2
R:R:T173	R:R:Y126	3.75	1	Yes	Yes	7	7	2	2
R:R:R208	R:R:Y126	3.09	0	No	Yes	5	7	1	2
R:R:T176	R:R:Y204	8.74	1	No	Yes	4	5	2	2
R:R:F291	R:R:V265	2.62	1	Yes	No	4	4	1	2
R:R:V272	R:R:W279	7.36	0	No	Yes	3	1	2	1
R:R:V277	R:R:W279	11.03	0	No	Yes	1	1	1	1
R:R:W279	R:R:Y284	9.65	0	Yes	No	1	3	1	2
R:R:F283	R:R:Q287	5.86	0	Yes	No	1	3	2	1
R:R:T288	R:R:Y289	11.24	0	No	No	4	1	1	2
R:R:F291	R:R:P292	5.78	1	Yes	No	4	4	1	2
R:R:F291	R:R:T295	7.78	1	Yes	No	4	6	1	1
L:L:L17	R:R:W279	2.28	0	Yes	Yes	0	1	0	1
R:R:C186	R:R:G187	1.96	0	No	No	2	5	1	2
M:M:A20	R:R:L190	1.58	0	No	Yes	0	3	0	1
L:L:M14	R:R:V277	1.52	0	No	No	0	1	0	1
R:R:L190	R:R:V188	1.49	0	Yes	No	3	3	1	2
R:R:L190	R:R:L192	1.38	0	Yes	No	3	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YJ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.33
Number of Linked Nodes	300
Number of Links	336
Number of Hubs	40
Number of Links mediated by Hubs	164
Number of Communities	12
Number of Nodes involved in Communities	61
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	58628
Length Of Smallest Path	3
Average Path Length	13.3416
Length of Longest Path	28
Minimum Path Strength	1.17
Average Path Strength	5.48724
Maximum Path Strength	17.56
Minimum Path Correlation	0.7
Average Path Correlation	0.941644
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	56.1353
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.1014
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • WD40 repeat-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU9
Sequence	>7YJ4_nogp_Chain_R F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D F H W P F G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M A A G P G T H L S L F W A R I A T L A V W A A A A L V T V P T A V F G V E G E V C G V R L C L L R F P S R Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R Q R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L V P W N S T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E P R Q A L A G T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YK7	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-	Gi2/β1/γ2	2.75	2023-03-01	10.1038/s41467-023-36182-z
	7YK7 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-		2.75	2023-03-01	10.1038/s41467-023-36182-z
	7YK6	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-	Gi2/β1/γ2	3.03	2023-03-01	10.1038/s41467-023-36182-z
	7YK6 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-		3.03	2023-03-01	10.1038/s41467-023-36182-z
	7YJ4	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-	Gi2/β1/γ2	3.19	2023-03-01	10.1038/s41467-023-36182-z
	7YJ4 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-		3.19	2023-03-01	10.1038/s41467-023-36182-z

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