psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:L3	R:R:V185	4.47	No	No	0	0	2
2	L:L:L3	R:R:R194	6.07	No	Yes	0	0	4
3	L:L:G5	L:L:S8	3.71	No	No	0	0	0
4	L:L:E19	L:L:L6	6.63	Yes	No	0	0	0
5	L:L:L6	L:L:S22	12.01	No	No	0	0	0
6	L:L:E19	L:L:S7	4.31	Yes	No	2	0	0
7	L:L:S7	N:N:F14	5.28	No	Yes	2	0	0
8	L:L:S7	R:R:C186	5.16	No	No	0	0	2
9	L:L:C10	L:L:C15	7.28	No	No	2	0	0
10	L:L:C10	L:L:E19	12.15	No	Yes	2	0	0
11	L:L:C11	N:N:L9	7.94	No	No	0	0	0
12	L:L:C11	N:N:C10	7.28	No	No	0	0	0
13	L:L:C15	L:L:E19	4.56	No	Yes	2	0	0
14	L:L:S16	L:L:S18	4.89	No	No	0	0	0
15	L:L:E19	N:N:F14	26.82	Yes	Yes	2	0	0
16	L:L:I20	L:L:L23	9.99	Yes	No	2	0	0
17	L:L:I20	N:N:F14	7.54	Yes	Yes	2	0	0
18	L:L:I20	N:N:T21	4.56	Yes	No	0	0	0
19	L:L:L23	N:N:F14	8.53	No	Yes	2	0	0
20	L:L:L23	N:N:V18	17.88	No	No	2	0	0
21	L:L:C24	N:N:C22	7.28	No	No	0	0	0
22	L:L:C24	R:R:R194	8.36	No	Yes	0	0	4
23	L:L:C24	R:R:S197	3.44	No	No	0	0	2
24	N:N:L9	R:R:C186	6.35	No	No	0	0	2
25	N:N:I15	N:N:R12	12.53	No	No	0	0	0
26	N:N:R12	R:R:D104	9.53	No	Yes	0	0	4
27	N:N:F14	N:N:V18	7.87	Yes	No	2	0	0
28	N:N:I15	R:R:V188	7.68	No	No	0	0	3
29	N:N:F20	N:N:R16	6.41	Yes	Yes	1	0	0
30	N:N:R16	R:R:R39	14.93	Yes	Yes	1	0	4
31	N:N:R16	R:R:D104	5.96	Yes	Yes	1	0	4
32	N:N:R16	R:R:F105	4.28	Yes	Yes	1	0	4
33	N:N:F20	N:N:I19	3.77	Yes	No	0	0	0
34	N:N:I19	R:R:L190	7.14	No	No	0	0	3
35	N:N:F20	N:N:S25	7.93	Yes	No	1	0	0
36	N:N:F20	R:R:Q287	15.23	Yes	Yes	1	0	3
37	N:N:C22	R:R:L192	6.35	No	No	0	0	3
38	N:N:S25	R:R:Q287	10.11	No	Yes	1	0	3
39	N:N:S25	R:R:F291	5.28	No	Yes	1	0	4
40	N:N:R26	N:N:W27	8	No	Yes	1	0	0
41	N:N:R26	R:R:W97	20.99	No	Yes	1	0	7
42	N:N:R26	R:R:E100	5.82	No	Yes	1	0	5
43	N:N:W27	R:R:T121	8.49	Yes	No	0	0	6
44	N:N:W27	R:R:V122	4.9	Yes	No	0	0	4
45	N:N:W27	R:R:V125	8.58	Yes	No	0	0	7
46	N:N:W27	R:R:Q205	4.38	Yes	Yes	1	0	5
47	N:N:W27	R:R:R208	7	Yes	Yes	1	0	5
48	N:N:W27	R:R:H299	5.29	Yes	No	0	0	7
49	R:R:F35	R:R:L36	3.65	No	No	0	3	3
50	R:R:D104	R:R:F35	9.55	Yes	No	0	4	3
51	R:R:L38	R:R:R39	3.64	No	Yes	0	4	4
52	R:R:D104	R:R:R39	10.72	Yes	Yes	1	4	4
53	R:R:F105	R:R:R39	9.62	Yes	Yes	1	4	4
54	R:R:P292	R:R:V42	3.53	No	No	0	4	5
55	R:R:T295	R:R:Y46	7.49	No	Yes	0	6	8
56	R:R:C296	R:R:Y46	5.38	No	Yes	0	4	8
57	R:R:C303	R:R:I52	6.55	No	No	0	6	5
58	R:R:C303	R:R:G53	3.92	No	No	0	6	9
59	R:R:L54	R:R:L88	4.15	No	No	0	6	7
60	R:R:G56	R:R:P306	4.06	No	No	0	8	9
61	R:R:D87	R:R:N57	6.73	Yes	No	0	9	9
62	R:R:L88	R:R:N57	5.49	No	No	0	7	9
63	R:R:N57	R:R:P306	6.52	No	No	0	9	9
64	R:R:C310	R:R:V60	10.25	No	No	0	7	9
65	R:R:F81	R:R:L61	3.65	Yes	No	0	6	6
66	R:R:V63	R:R:W62	12.26	No	Yes	0	7	3
67	R:R:L320	R:R:W62	4.56	No	Yes	4	7	3
68	R:R:T323	R:R:W62	10.92	No	Yes	0	4	3
69	R:R:F324	R:R:W62	11.02	No	Yes	4	6	3
70	R:R:C310	R:R:L64	4.76	No	No	0	7	7
71	R:R:G73	R:R:P74	4.06	No	No	0	6	7
72	R:R:D77	R:R:P74	17.71	No	No	0	7	7
73	R:R:F79	R:R:S76	3.96	Yes	No	0	7	8
74	R:R:R159	R:R:T78	10.35	No	No	0	4	6
75	R:R:F79	R:R:L135	6.09	Yes	No	0	7	8
76	R:R:F79	R:R:T162	3.89	Yes	Yes	0	7	6
77	R:R:F81	R:R:L85	7.31	Yes	No	0	6	5
78	R:R:L131	R:R:N82	5.49	No	Yes	0	8	9
79	R:R:N82	R:R:T162	14.62	Yes	Yes	0	9	6
80	R:R:N82	R:R:W166	4.52	Yes	Yes	0	9	9
81	R:R:D87	R:R:L83	5.43	Yes	Yes	3	9	9
82	R:R:L83	R:R:S128	4.5	Yes	No	3	9	9
83	R:R:L131	R:R:L83	4.15	No	Yes	0	8	9
84	R:R:I132	R:R:L83	4.28	No	Yes	3	8	9
85	R:R:L83	R:R:N305	6.87	Yes	Yes	3	9	9
86	R:R:D87	R:R:S128	8.83	Yes	No	3	9	9
87	R:R:D87	R:R:S302	8.83	Yes	No	0	9	8
88	R:R:D87	R:R:N305	6.73	Yes	Yes	3	9	9
89	R:R:L90	R:R:N124	6.87	Yes	No	0	7	8
90	R:R:L90	R:R:V125	4.47	Yes	No	0	7	7
91	R:R:H299	R:R:L90	7.71	No	Yes	0	7	7
92	R:R:L90	R:R:S302	4.5	Yes	No	0	7	8
93	R:R:H299	R:R:L94	16.71	No	Yes	0	7	8
94	R:R:F96	R:R:V117	9.18	No	No	0	6	5
95	R:R:E100	R:R:W97	5.45	Yes	Yes	1	5	7
96	R:R:V117	R:R:W97	3.68	No	Yes	0	5	7
97	R:R:L118	R:R:W97	5.69	No	Yes	0	5	7
98	R:R:T121	R:R:W97	4.85	No	Yes	0	6	7
99	R:R:E100	R:R:S101	4.31	Yes	No	1	5	4
100	R:R:E100	R:R:F105	9.33	Yes	Yes	1	5	4
101	R:R:E100	R:R:W107	4.36	Yes	Yes	1	5	9
102	R:R:F105	R:R:S101	7.93	Yes	No	1	4	4
103	R:R:L103	R:R:P108	6.57	No	No	0	4	3
104	R:R:H106	R:R:V188	17.99	No	No	0	4	3
105	R:R:F109	R:R:W107	17.04	No	Yes	0	7	9
106	R:R:C114	R:R:W107	3.92	No	Yes	1	9	9
107	R:R:C191	R:R:W107	7.84	No	Yes	1	9	9
108	R:R:F109	R:R:L113	8.53	No	No	0	7	6
109	R:R:C114	R:R:E182	4.56	No	Yes	0	9	4
110	R:R:C114	R:R:C191	7.28	No	No	1	9	9
111	R:R:G180	R:R:K115	5.23	No	No	0	5	7
112	R:R:K115	R:R:V181	4.55	No	No	0	7	4
113	R:R:C191	R:R:L118	4.76	No	No	0	9	5
114	R:R:L118	R:R:L193	4.15	No	No	0	5	5
115	R:R:T119	R:R:T176	6.28	No	No	0	6	4
116	R:R:T173	R:R:V122	4.76	Yes	No	0	7	4
117	R:R:T176	R:R:V122	4.76	No	No	0	4	4
118	R:R:L123	R:R:W166	6.83	No	Yes	0	5	9
119	R:R:L123	R:R:T173	4.42	No	Yes	0	5	7
120	R:R:V125	R:R:W259	4.9	No	Yes	0	7	9
121	R:R:V172	R:R:Y126	7.57	No	Yes	1	4	7
122	R:R:T173	R:R:Y126	3.75	Yes	Yes	0	7	7
123	R:R:Q207	R:R:Y126	4.51	No	Yes	1	2	7
124	R:R:R208	R:R:Y126	7.2	Yes	Yes	1	5	7
125	R:R:A127	R:R:W166	7.78	No	Yes	0	7	9
126	R:R:F255	R:R:I129	5.02	No	No	1	9	8
127	R:R:I129	R:R:W259	8.22	No	Yes	1	8	9
128	R:R:F130	R:R:L211	3.65	No	No	0	6	4
129	R:R:I132	R:R:N305	5.66	No	Yes	3	8	9
130	R:R:I132	R:R:Y309	10.88	No	Yes	3	8	9
131	R:R:P216	R:R:T133	3.5	No	No	0	9	7
132	R:R:I220	R:R:T133	6.08	No	No	0	8	7
133	R:R:L135	R:R:Y309	3.52	No	Yes	0	8	9
134	R:R:I220	R:R:S136	6.19	No	No	0	8	9
135	R:R:S136	R:R:S223	4.89	No	No	0	9	7
136	R:R:S136	R:R:Y224	5.09	No	Yes	0	9	9
137	R:R:R139	R:R:Y224	10.29	No	Yes	0	9	9
138	R:R:R139	R:R:Y309	4.12	No	Yes	0	9	9
139	R:R:A144	R:R:Y140	8.01	No	Yes	0	7	7
140	R:R:L226	R:R:Y140	14.07	No	Yes	0	4	7
141	R:R:L227	R:R:Y140	4.69	No	Yes	0	8	7
142	R:R:M145	R:R:W141	8.14	No	No	0	5	5
143	R:R:L153	R:R:W141	4.56	No	No	0	7	5
144	R:R:H152	R:R:V142	4.15	No	No	0	3	8
145	R:R:A144	R:R:F230	9.71	No	No	0	7	5
146	R:R:A146	R:R:H152	8.78	No	No	0	8	3
147	R:R:G148	R:R:P149	4.06	No	No	0	5	5
148	R:R:S154	R:R:W157	8.65	No	Yes	0	5	3
149	R:R:L155	R:R:R159	3.64	No	No	0	3	4
150	R:R:F156	R:R:W157	4.01	No	Yes	6	4	3
151	R:R:F156	R:R:I160	7.54	No	No	6	4	3
152	R:R:I160	R:R:W157	3.52	No	Yes	6	3	3
153	R:R:Q207	R:R:V172	7.16	No	No	1	2	4
154	R:R:L211	R:R:V172	4.47	No	No	1	4	4
155	R:R:P175	R:R:V174	5.3	No	No	0	9	4
156	R:R:P175	R:R:W200	4.05	No	Yes	0	9	2
157	R:R:P175	R:R:Y204	12.52	No	No	0	9	5
158	R:R:T176	R:R:Y204	8.74	No	No	0	4	5
159	R:R:F179	R:R:V178	6.55	No	No	0	4	4
160	R:R:F179	R:R:F195	21.43	No	No	7	4	4
161	R:R:F179	R:R:W200	20.04	No	Yes	7	4	2
162	R:R:R194	R:R:V181	3.92	Yes	No	0	4	4
163	R:R:E182	R:R:G183	6.55	Yes	No	0	4	1
164	R:R:E182	R:R:E184	3.81	Yes	No	0	4	2
165	R:R:E182	R:R:R189	3.49	Yes	No	0	4	4
166	R:R:G183	R:R:R194	4.5	No	Yes	0	1	4
167	R:R:L192	R:R:R194	3.64	No	Yes	0	3	4
168	R:R:L193	R:R:W200	6.83	No	Yes	0	5	2
169	R:R:F195	R:R:P196	17.34	No	No	0	4	5
170	R:R:F195	R:R:W200	16.04	No	Yes	7	4	2
171	R:R:R198	R:R:Y199	15.43	No	No	0	2	1
172	R:R:L201	R:R:W200	5.69	No	Yes	0	4	2
173	R:R:K273	R:R:L201	9.87	Yes	No	0	3	4
174	R:R:G202	R:R:K273	5.23	No	Yes	0	3	3
175	R:R:F274	R:R:G202	4.52	No	No	0	3	3
176	R:R:Q205	R:R:Y204	4.51	Yes	No	0	5	5
177	R:R:Q205	R:R:R208	4.67	Yes	Yes	1	5	5
178	R:R:K273	R:R:Q205	4.07	Yes	Yes	0	3	5
179	R:R:L211	R:R:Q207	6.65	No	No	1	4	2
180	R:R:N262	R:R:R208	4.82	Yes	Yes	1	7	5
181	R:R:H263	R:R:R208	5.64	Yes	Yes	0	8	5
182	R:R:R208	R:R:T266	3.88	Yes	No	1	5	5
183	R:R:H263	R:R:V209	6.92	Yes	No	0	8	5
184	R:R:L267	R:R:V209	5.96	No	No	0	5	5
185	R:R:F213	R:R:M214	4.98	Yes	No	0	9	4
186	R:R:F213	R:R:F256	5.36	Yes	No	8	9	5
187	R:R:F213	R:R:F260	9.65	Yes	No	8	9	6
188	R:R:F213	R:R:H263	14.71	Yes	Yes	0	9	8
189	R:R:P216	R:R:V215	3.53	No	No	0	9	5
190	R:R:F255	R:R:L217	3.65	No	Yes	0	9	5
191	R:R:F256	R:R:L217	3.65	No	Yes	0	5	5
192	R:R:V248	R:R:Y224	12.62	No	Yes	0	7	9
193	R:R:L251	R:R:Y224	4.69	No	Yes	0	8	9
194	R:R:L228	R:R:V244	4.47	No	No	0	4	7
195	R:R:F230	R:R:R234	11.76	No	No	5	5	5
196	R:R:L231	R:R:R237	12.15	Yes	No	9	8	3
197	R:R:L231	R:R:S241	6.01	Yes	No	9	8	7
198	R:R:L231	R:R:V244	4.47	Yes	No	0	8	7
199	R:R:Q232	R:R:R238	3.5	No	No	0	4	3
200	R:R:Q235	R:R:R236	4.67	No	No	0	4	3
201	R:R:D240	R:R:R237	8.34	No	No	0	5	3
202	R:R:R237	R:R:S241	6.59	No	No	9	3	7
203	R:R:Q239	R:R:R242	4.67	No	No	0	3	4
204	R:R:R246	R:R:R249	6.4	No	No	0	6	4
205	R:R:I250	R:R:L308	4.28	No	No	0	5	8
206	R:R:L251	R:R:L308	5.54	No	No	0	8	8
207	R:R:L251	R:R:Y309	10.55	No	Yes	0	8	9
208	R:R:L304	R:R:S254	6.01	No	No	0	6	6
209	R:R:F255	R:R:W259	4.01	No	Yes	1	9	9
210	R:R:F256	R:R:F260	20.36	No	No	8	5	6
211	R:R:C258	R:R:S300	3.44	No	No	0	7	5
212	R:R:C258	R:R:N301	6.3	No	No	0	7	9
213	R:R:N262	R:R:W259	5.65	Yes	Yes	1	7	9
214	R:R:H263	R:R:W259	8.46	Yes	Yes	0	8	9
215	R:R:A298	R:R:W259	6.48	No	Yes	0	8	9
216	R:R:N301	R:R:W259	9.04	No	Yes	0	9	9
217	R:R:F260	R:R:V264	7.87	No	No	0	6	5
218	R:R:P261	R:R:T294	3.5	No	Yes	0	9	7
219	R:R:L297	R:R:P261	6.57	No	No	0	7	9
220	R:R:N262	R:R:T266	4.39	Yes	No	1	7	5
221	R:R:N262	R:R:T294	4.39	Yes	Yes	0	7	7
222	R:R:L267	R:R:V270	4.47	No	No	0	5	6
223	R:R:T282	R:R:W268	12.13	No	No	0	3	4
224	R:R:I286	R:R:W268	8.22	No	No	0	2	4
225	R:R:F283	R:R:G269	4.52	Yes	No	0	1	4
226	R:R:K273	R:R:V270	4.55	Yes	No	0	3	6
227	R:R:D275	R:R:L271	5.43	No	No	10	1	4
228	R:R:L271	R:R:L276	4.15	No	No	10	4	1
229	R:R:V272	R:R:V277	4.81	Yes	No	1	3	1
230	R:R:V272	R:R:W279	8.58	Yes	Yes	1	3	1
231	R:R:F283	R:R:V272	3.93	Yes	Yes	1	1	3
232	R:R:D275	R:R:L276	5.43	No	No	10	1	1
233	R:R:V277	R:R:W279	6.13	No	Yes	1	1	1
234	R:R:N280	R:R:P278	6.52	No	No	0	4	3
235	R:R:T282	R:R:W279	3.64	No	Yes	1	3	1
236	R:R:F283	R:R:W279	4.01	Yes	Yes	1	1	1
237	R:R:S281	R:R:T285	6.4	No	No	0	7	3
238	R:R:F283	R:R:T282	3.89	Yes	No	1	1	3
239	R:R:F283	R:R:Q287	15.23	Yes	Yes	1	1	3
240	R:R:I286	R:R:T285	4.56	No	No	0	2	3
241	R:R:I286	R:R:V290	7.68	No	No	0	2	5
242	R:R:F291	R:R:Q287	10.54	Yes	Yes	1	4	3
243	R:R:F291	R:R:T294	5.19	Yes	Yes	0	4	7
244	R:R:F291	R:R:T295	7.78	Yes	No	0	4	6
245	R:R:N301	R:R:N305	5.45	No	Yes	0	9	9
246	R:R:N305	R:R:Y309	6.98	Yes	Yes	3	9	9
247	R:R:L312	R:R:R313	12.15	No	No	0	6	8
248	R:R:P316	R:R:R313	5.76	No	No	0	7	8
249	R:R:R314	R:R:R317	17.06	No	No	0	5	9
250	R:R:Q318	R:R:R314	15.19	No	No	0	4	5
251	R:R:E315	R:R:P316	6.29	No	No	0	6	7
252	R:R:F324	R:R:L320	6.09	No	No	4	6	7
253	N:N:G23	R:R:L201	3.42	No	No	0	0	4
254	R:R:G50	R:R:L94	3.42	No	Yes	0	6	8
255	R:R:G89	R:R:L92	3.42	No	No	0	7	5
256	R:R:A84	R:R:V60	3.39	No	No	0	8	9
257	R:R:G89	R:R:N124	3.39	No	No	0	7	8
258	N:N:C22	N:N:T21	3.38	No	No	0	0	0
259	R:R:A158	R:R:T78	3.36	No	No	0	8	6
260	L:L:S22	L:L:V2	3.23	No	No	0	0	0
261	R:R:C310	R:R:L311	3.17	No	No	0	7	6
262	R:R:A245	R:R:L228	3.15	No	No	0	5	4
263	L:L:K12	L:L:S8	3.06	No	No	0	0	0
264	L:L:K17	L:L:S21	3.06	No	No	0	0	0
265	R:R:L308	R:R:S254	3	No	No	0	8	6
266	R:R:L94	R:R:V49	2.98	Yes	No	0	8	7
267	R:R:L64	R:R:V80	2.98	No	No	0	7	8
268	R:R:L135	R:R:V80	2.98	No	No	0	8	8
269	R:R:L131	R:R:V165	2.98	No	No	0	8	7
270	R:R:L227	R:R:V143	2.98	No	No	0	8	8
271	R:R:L228	R:R:V248	2.98	No	No	0	4	7
272	R:R:L92	R:R:T93	2.95	No	No	0	5	6
273	R:R:L217	R:R:T221	2.95	Yes	No	0	5	4
274	R:R:L225	R:R:T221	2.95	No	No	0	3	4
275	R:R:F109	R:R:P108	2.89	No	No	0	7	3
276	R:R:G110	R:R:W107	2.81	No	Yes	0	8	9
277	R:R:A134	R:R:F79	2.77	No	Yes	0	7	7
278	R:R:A161	R:R:F79	2.77	No	Yes	0	5	7
279	R:R:A168	R:R:F130	2.77	No	No	0	4	6
280	R:R:L227	R:R:L231	2.77	No	Yes	0	8	8
281	R:R:A229	R:R:R233	2.77	No	No	0	3	5
282	R:R:A321	R:R:R325	2.77	No	No	0	3	6
283	R:R:A98	R:R:Y46	2.67	No	Yes	0	6	8
284	R:R:A212	R:R:Y126	2.67	No	Yes	0	6	7
285	R:R:F291	R:R:V265	2.62	Yes	No	0	4	4
286	N:N:F20	R:R:T288	2.59	Yes	No	0	0	4
287	R:R:A59	R:R:W62	2.59	No	Yes	0	6	3
288	R:R:F79	R:R:T78	2.59	Yes	No	0	7	6
289	R:R:A86	R:R:W166	2.59	No	Yes	0	8	9
290	R:R:A146	R:R:W141	2.59	No	No	0	8	5
291	R:R:R159	R:R:T162	2.59	No	Yes	0	4	6
292	R:R:V42	R:R:Y46	2.52	No	Yes	0	5	8
293	R:R:M145	R:R:Y140	2.39	No	Yes	0	5	7
294	R:R:D275	R:R:F274	2.39	No	No	0	1	3
295	L:L:K12	L:L:W13	2.32	No	No	0	0	0
296	N:N:G23	N:N:G24	2.11	No	No	0	0	0
297	R:R:G110	R:R:G111	2.11	No	No	0	8	3
298	L:L:A4	L:L:G5	1.95	No	No	0	0	0
299	R:R:A91	R:R:G53	1.95	No	No	0	6	9
300	R:R:A59	R:R:G56	1.95	No	No	0	6	8
301	R:R:P74	R:R:P75	1.95	No	No	0	7	7
302	R:R:A147	R:R:G148	1.95	No	No	0	5	5
303	R:R:A321	R:R:G322	1.95	No	No	0	3	4
304	R:R:G187	R:R:V188	1.84	No	No	0	5	3
305	L:L:A4	R:R:C186	1.81	No	No	0	0	2
306	R:R:A45	R:R:C296	1.81	No	No	0	4	4
307	R:R:A43	R:R:A98	1.79	No	No	0	6	6
308	R:R:A102	R:R:A43	1.79	No	No	0	3	6
309	R:R:A127	R:R:A169	1.79	No	No	0	7	8
310	R:R:P278	R:R:V272	1.77	No	Yes	0	3	3
311	R:R:P75	R:R:T151	1.75	No	No	0	7	5
312	R:R:C303	R:R:V49	1.71	No	No	0	6	7
313	R:R:G56	R:R:L55	1.71	No	No	0	8	4
314	R:R:A138	R:R:S76	1.71	No	No	0	8	8
315	R:R:A91	R:R:S302	1.71	No	No	0	6	8
316	R:R:G218	R:R:L217	1.71	No	Yes	0	2	5
317	R:R:A177	R:R:T119	1.68	No	No	0	4	6
318	R:R:A170	R:R:T173	1.68	No	Yes	0	3	7
319	N:N:E13	N:N:G11	1.64	No	No	0	0	0
320	R:R:L153	R:R:P75	1.64	No	No	0	7	7
321	R:R:L94	R:R:P95	1.64	Yes	No	0	8	9
322	L:L:I20	N:N:A17	1.62	Yes	No	0	0	0
323	R:R:S223	R:R:V137	1.62	No	No	0	7	6
324	R:R:S223	R:R:V219	1.62	No	No	0	7	6
325	R:R:S247	R:R:V243	1.62	No	No	0	7	7
326	R:R:T221	R:R:V252	1.59	No	No	0	4	8
327	R:R:T294	R:R:V293	1.59	Yes	No	0	7	5
328	L:L:L6	L:L:S18	1.5	No	No	0	0	0
329	R:R:L206	R:R:V210	1.49	No	No	0	4	5
330	R:R:L304	R:R:V307	1.49	No	No	0	6	6
331	R:R:L163	R:R:T162	1.47	No	Yes	0	3	6
332	L:L:D1	L:L:V2	1.46	No	No	0	0	0
333	R:R:G47	R:R:Y46	1.45	No	Yes	0	5	8
334	L:L:G14	L:L:W13	1.41	No	No	0	0	0
335	R:R:P196	R:R:Y199	1.39	No	No	0	5	1
336	R:R:L36	R:R:L40	1.38	No	No	0	3	4
337	R:R:L58	R:R:L61	1.38	No	No	0	2	6
338	R:R:L206	R:R:L267	1.38	No	No	0	4	5
339	R:R:F81	R:R:S65	1.32	Yes	No	0	6	4
340	R:R:R249	R:R:V248	1.31	No	No	0	4	7
341	R:R:A319	R:R:W62	1.3	No	Yes	0	5	3
342	R:R:V290	R:R:Y289	1.26	No	No	0	5	1
343	R:R:F81	R:R:N82	1.21	Yes	Yes	0	6	9
344	R:R:Q239	R:R:R238	1.17	No	No	0	3	3
345	R:R:L153	R:R:W157	1.14	No	Yes	0	7	3
346	R:R:F230	R:R:R233	1.07	No	No	5	5	5
347	R:R:R233	R:R:R234	1.07	No	No	5	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:E19	10.894	5	2	0
2	L:L:I20	5.9275	4	2	0
3	N:N:F14	11.208	5	2	0
4	N:N:R16	7.895	4	1	0
5	N:N:F20	7.186	5	1	0
6	N:N:W27	6.66286	7	1	0
7	R:R:R39	9.7275	4	1	4
8	R:R:Y46	3.902	5	0	8
9	R:R:W62	7.10833	6	4	3
10	R:R:F79	3.67833	6	0	7
11	R:R:F81	3.3725	4	0	6
12	R:R:N82	6.46	4	0	9
13	R:R:L83	5.046	5	3	9
14	R:R:D87	7.31	5	3	9
15	R:R:L90	5.8875	4	0	7
16	R:R:L94	6.1875	4	0	8
17	R:R:W97	8.132	5	1	7
18	R:R:E100	5.854	5	1	5
19	R:R:D104	8.94	4	1	4
20	R:R:F105	7.79	4	1	4
21	R:R:W107	7.194	5	1	9
22	R:R:Y126	5.14	5	1	7
23	R:R:Y140	7.29	4	0	7
24	R:R:W157	4.33	4	6	3
25	R:R:T162	5.6425	4	0	6
26	R:R:W166	5.43	4	0	9
27	R:R:T173	3.6525	4	0	7
28	R:R:E182	4.6025	4	0	4
29	R:R:R194	5.298	5	0	4
30	R:R:W200	10.53	5	7	2
31	R:R:Q205	4.4075	4	1	5
32	R:R:R208	5.535	6	1	5
33	R:R:F213	8.675	4	8	9
34	R:R:L217	2.99	4	0	5
35	R:R:Y224	8.1725	4	0	9
36	R:R:L231	6.35	4	9	8
37	R:R:W259	6.68	7	1	9
38	R:R:N262	4.8125	4	1	7
39	R:R:H263	8.9325	4	0	8
40	R:R:V272	4.7725	4	1	3
41	R:R:K273	5.93	4	0	3
42	R:R:W279	5.59	4	1	1
43	R:R:F283	6.316	5	1	1
44	R:R:Q287	12.7775	4	1	3
45	R:R:F291	6.282	5	1	4
46	R:R:T294	3.6675	4	0	7
47	R:R:N305	6.338	5	3	9
48	R:R:Y309	7.21	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:A4	L:L:G5	10.0535	1.95	No	No	0	0	0
2	L:L:A4	R:R:C186	12.0494	1.81	No	No	0	0	2
3	L:L:S7	R:R:C186	19.9816	5.16	No	No	0	0	2
4	L:L:S7	N:N:F14	21.6981	5.28	No	Yes	2	0	0
5	L:L:I20	N:N:F14	43.2016	7.54	Yes	Yes	2	0	0
6	L:L:I20	N:N:T21	50.7597	4.56	Yes	No	0	0	0
7	N:N:C22	N:N:T21	52.6581	3.38	No	No	0	0	0
8	L:L:C24	N:N:C22	27.3065	7.28	No	No	0	0	0
9	L:L:C24	R:R:R194	29.1102	8.36	No	Yes	0	0	4
10	N:N:C22	R:R:L192	27.245	6.35	No	No	0	0	3
11	R:R:L192	R:R:R194	28.1469	3.64	No	Yes	0	3	4
12	L:L:E19	N:N:F14	17.7526	26.82	Yes	Yes	2	0	0
13	L:L:E19	L:L:L6	12.0494	6.63	Yes	No	0	0	0
14	R:R:G183	R:R:R194	62.0225	4.5	No	Yes	0	1	4
15	R:R:E182	R:R:G183	62.8244	6.55	Yes	No	0	4	1
16	R:R:C114	R:R:E182	65.161	4.56	No	Yes	0	9	4
17	R:R:C114	R:R:W107	60.5493	3.92	No	Yes	1	9	9
18	R:R:E100	R:R:W107	66.0526	4.36	Yes	Yes	1	5	9
19	R:R:E100	R:R:F105	30.7166	9.33	Yes	Yes	1	5	4
20	N:N:R16	R:R:F105	20.1609	4.28	Yes	Yes	1	0	4
21	N:N:R16	R:R:D104	15.2853	5.96	Yes	Yes	1	0	4
22	N:N:R12	R:R:D104	13.105	9.53	No	Yes	0	0	4
23	N:N:I15	N:N:R12	10.5634	12.53	No	No	0	0	0
24	R:R:F105	R:R:R39	10.0074	9.62	Yes	Yes	1	4	4
25	N:N:F20	N:N:R16	19.0925	6.41	Yes	Yes	1	0	0
26	N:N:F20	R:R:Q287	13.4099	15.23	Yes	Yes	1	0	3
27	R:R:F291	R:R:Q287	20.2147	10.54	Yes	Yes	1	4	3
28	N:N:R26	R:R:E100	68.0024	5.82	No	Yes	1	0	5
29	N:N:R26	N:N:W27	72.322	8	No	Yes	1	0	0
30	N:N:W27	R:R:V122	14.1298	4.9	Yes	No	0	0	4
31	N:N:W27	R:R:Q205	17.2094	4.38	Yes	Yes	1	0	5
32	N:N:W27	R:R:R208	11.0963	7	Yes	Yes	1	0	5
33	N:N:W27	R:R:H299	15.3545	5.29	Yes	No	0	0	7
34	R:R:F291	R:R:T295	12.8334	7.78	Yes	No	0	4	6
35	R:R:T295	R:R:Y46	11.5729	7.49	No	Yes	0	6	8
36	N:N:W27	R:R:V125	58.638	8.58	Yes	No	0	0	7
37	R:R:L90	R:R:V125	12.3312	4.47	Yes	No	0	7	7
38	R:R:L90	R:R:S302	21.2037	4.5	Yes	No	0	7	8
39	R:R:H299	R:R:L90	12.7642	7.71	No	Yes	0	7	7
40	R:R:D87	R:R:S302	20.2224	8.83	Yes	No	0	9	8
41	R:R:D87	R:R:N57	18.452	6.73	Yes	No	0	9	9
42	R:R:N57	R:R:P306	14.2015	6.52	No	No	0	9	9
43	R:R:G56	R:R:P306	12.7745	4.06	No	No	0	8	9
44	R:R:V125	R:R:W259	49.6144	4.9	No	Yes	0	7	9
45	R:R:N301	R:R:W259	97.5353	9.04	No	Yes	0	9	9
46	R:R:N301	R:R:N305	96.1671	5.45	No	Yes	0	9	9
47	R:R:N305	R:R:Y309	100	6.98	Yes	Yes	3	9	9
48	R:R:L135	R:R:Y309	20.0994	3.52	No	Yes	0	8	9
49	R:R:T173	R:R:V122	11.9085	4.76	Yes	No	0	7	4
50	R:R:L123	R:R:T173	15.954	4.42	No	Yes	0	5	7
51	R:R:L123	R:R:W166	16.077	6.83	No	Yes	0	5	9
52	R:R:N82	R:R:W166	16.8456	4.52	Yes	Yes	0	9	9
53	R:R:R139	R:R:Y309	47.0165	4.12	No	Yes	0	9	9
54	R:R:R139	R:R:Y224	46.1018	10.29	No	Yes	0	9	9
55	R:R:V248	R:R:Y224	74.0898	12.62	No	Yes	0	7	9
56	R:R:L228	R:R:V248	67.7564	2.98	No	No	0	4	7
57	R:R:L228	R:R:V244	63.5111	4.47	No	No	0	4	7
58	R:R:L231	R:R:V244	61.4998	4.47	Yes	No	0	8	7
59	R:R:L227	R:R:L231	52.9348	2.77	No	Yes	0	8	8
60	R:R:L227	R:R:Y140	48.6869	4.69	No	Yes	0	8	7
61	R:R:M145	R:R:Y140	33.4196	2.39	No	Yes	0	5	7
62	R:R:M145	R:R:W141	31.2188	8.14	No	No	0	5	5
63	R:R:L153	R:R:W141	22.3643	4.56	No	No	0	7	5
64	R:R:L153	R:R:P75	11.309	1.64	No	No	0	7	7
65	R:R:L251	R:R:Y309	52.3328	10.55	No	Yes	0	8	9
66	R:R:L251	R:R:Y224	46.5989	4.69	No	Yes	0	8	9
67	R:R:N82	R:R:T162	11.3013	14.62	Yes	Yes	0	9	6
68	R:R:F79	R:R:L135	12.9717	6.09	Yes	No	0	7	8
69	R:R:L131	R:R:N82	10.5224	5.49	No	Yes	0	8	9
70	R:R:L131	R:R:L83	13.2484	4.15	No	Yes	0	8	9
71	R:R:R208	R:R:Y126	18.0216	7.2	Yes	Yes	1	5	7
72	R:R:S136	R:R:Y224	18.0344	5.09	No	Yes	0	9	9
73	R:R:A144	R:R:Y140	11.3038	8.01	No	Yes	0	7	7
74	R:R:Q205	R:R:Y204	13.0127	4.51	Yes	No	0	5	5
75	R:R:P175	R:R:Y204	12.116	12.52	No	No	0	9	5
76	R:R:F195	R:R:W200	11.3525	16.04	No	Yes	7	4	2
77	R:R:L201	R:R:W200	11.4857	5.69	No	Yes	0	4	2
78	R:R:K273	R:R:Q205	25.0544	4.07	Yes	Yes	0	3	5
79	R:R:K273	R:R:L201	15.1828	9.87	Yes	No	0	3	4
80	R:R:N262	R:R:R208	22.5001	4.82	Yes	Yes	1	7	5
81	R:R:H263	R:R:R208	18.7697	5.64	Yes	Yes	0	8	5
82	R:R:N262	R:R:T294	34.5213	4.39	Yes	Yes	0	7	7
83	R:R:F283	R:R:Q287	14.9855	15.23	Yes	Yes	1	1	3
84	R:R:F291	R:R:T294	31.539	5.19	Yes	Yes	0	4	7
85	R:R:N262	R:R:W259	38.3336	5.65	Yes	Yes	1	7	9
86	R:R:Q205	R:R:R208	22.1362	4.67	Yes	Yes	1	5	5
87	R:R:D87	R:R:N305	12.0878	6.73	Yes	Yes	3	9	9
88	R:R:H263	R:R:W259	18.2829	8.46	Yes	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:L3	R:R:V185	4.47	0	No	No	0	2	0	1
L:L:L3	R:R:R194	6.07	0	No	Yes	0	4	0	1
L:L:S7	R:R:C186	5.16	2	No	No	0	2	0	1
L:L:C24	R:R:R194	8.36	0	No	Yes	0	4	0	1
L:L:C24	R:R:S197	3.44	0	No	No	0	2	0	1
N:N:L9	R:R:C186	6.35	0	No	No	0	2	0	1
N:N:R12	R:R:D104	9.53	0	No	Yes	0	4	0	1
N:N:I15	R:R:V188	7.68	0	No	No	0	3	0	1
N:N:R16	R:R:R39	14.93	1	Yes	Yes	0	4	0	1
N:N:R16	R:R:D104	5.96	1	Yes	Yes	0	4	0	1
N:N:R16	R:R:F105	4.28	1	Yes	Yes	0	4	0	1
N:N:I19	R:R:L190	7.14	0	No	No	0	3	0	1
N:N:F20	R:R:Q287	15.23	1	Yes	Yes	0	3	0	1
N:N:C22	R:R:L192	6.35	0	No	No	0	3	0	1
N:N:S25	R:R:Q287	10.11	1	No	Yes	0	3	0	1
N:N:S25	R:R:F291	5.28	1	No	Yes	0	4	0	1
N:N:R26	R:R:W97	20.99	1	No	Yes	0	7	0	1
N:N:R26	R:R:E100	5.82	1	No	Yes	0	5	0	1
N:N:W27	R:R:T121	8.49	1	Yes	No	0	6	0	1
N:N:W27	R:R:V122	4.9	1	Yes	No	0	4	0	1
N:N:W27	R:R:V125	8.58	1	Yes	No	0	7	0	1
N:N:W27	R:R:Q205	4.38	1	Yes	Yes	0	5	0	1
N:N:W27	R:R:R208	7	1	Yes	Yes	0	5	0	1
N:N:W27	R:R:H299	5.29	1	Yes	No	0	7	0	1
R:R:D104	R:R:F35	9.55	1	Yes	No	4	3	1	2
R:R:L38	R:R:R39	3.64	0	No	Yes	4	4	2	1
R:R:D104	R:R:R39	10.72	1	Yes	Yes	4	4	1	1
R:R:F105	R:R:R39	9.62	1	Yes	Yes	4	4	1	1
R:R:L90	R:R:V125	4.47	0	Yes	No	7	7	2	1
R:R:H299	R:R:L90	7.71	0	No	Yes	7	7	1	2
R:R:H299	R:R:L94	16.71	0	No	Yes	7	8	1	2
R:R:E100	R:R:W97	5.45	1	Yes	Yes	5	7	1	1
R:R:V117	R:R:W97	3.68	0	No	Yes	5	7	2	1
R:R:L118	R:R:W97	5.69	0	No	Yes	5	7	2	1
R:R:T121	R:R:W97	4.85	0	No	Yes	6	7	1	1
R:R:E100	R:R:S101	4.31	1	Yes	No	5	4	1	2
R:R:E100	R:R:F105	9.33	1	Yes	Yes	5	4	1	1
R:R:E100	R:R:W107	4.36	1	Yes	Yes	5	9	1	2
R:R:F105	R:R:S101	7.93	1	Yes	No	4	4	1	2
R:R:H106	R:R:V188	17.99	0	No	No	4	3	2	1
R:R:T173	R:R:V122	4.76	0	Yes	No	7	4	2	1
R:R:T176	R:R:V122	4.76	0	No	No	4	4	2	1
R:R:V125	R:R:W259	4.9	0	No	Yes	7	9	1	2
R:R:T173	R:R:Y126	3.75	0	Yes	Yes	7	7	2	2
R:R:R208	R:R:Y126	7.2	1	Yes	Yes	5	7	1	2
R:R:T176	R:R:Y204	8.74	0	No	No	4	5	2	2
R:R:R194	R:R:V181	3.92	0	Yes	No	4	4	1	2
R:R:G183	R:R:R194	4.5	0	No	Yes	1	4	2	1
R:R:L192	R:R:R194	3.64	0	No	Yes	3	4	1	1
R:R:L201	R:R:W200	5.69	0	No	Yes	4	2	1	2
R:R:K273	R:R:L201	9.87	0	Yes	No	3	4	2	1
R:R:Q205	R:R:Y204	4.51	1	Yes	No	5	5	1	2
R:R:Q205	R:R:R208	4.67	1	Yes	Yes	5	5	1	1
R:R:K273	R:R:Q205	4.07	0	Yes	Yes	3	5	2	1
R:R:N262	R:R:R208	4.82	1	Yes	Yes	7	5	2	1
R:R:H263	R:R:R208	5.64	0	Yes	Yes	8	5	2	1
R:R:R208	R:R:T266	3.88	1	Yes	No	5	5	1	2
R:R:N262	R:R:W259	5.65	1	Yes	Yes	7	9	2	2
R:R:H263	R:R:W259	8.46	0	Yes	Yes	8	9	2	2
R:R:N262	R:R:T266	4.39	1	Yes	No	7	5	2	2
R:R:N262	R:R:T294	4.39	1	Yes	Yes	7	7	2	2
R:R:F283	R:R:Q287	15.23	1	Yes	Yes	1	3	2	1
R:R:F291	R:R:Q287	10.54	1	Yes	Yes	4	3	1	1
R:R:F291	R:R:T294	5.19	1	Yes	Yes	4	7	1	2
R:R:F291	R:R:T295	7.78	1	Yes	No	4	6	1	2
N:N:G23	R:R:L201	3.42	0	No	No	0	4	0	1
R:R:F291	R:R:V265	2.62	1	Yes	No	4	4	1	2
N:N:F20	R:R:T288	2.59	1	Yes	No	0	4	0	1
R:R:G187	R:R:V188	1.84	0	No	No	5	3	2	1
L:L:A4	R:R:C186	1.81	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9KFK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.44
Number of Linked Nodes	308
Number of Links	347
Number of Hubs	48
Number of Links mediated by Hubs	182
Number of Communities	10
Number of Nodes involved in Communities	67
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	89
Number Of Links MetaPath	88
Number of Shortest Paths	92733
Length Of Smallest Path	3
Average Path Length	15.5082
Length of Longest Path	40
Minimum Path Strength	1.265
Average Path Strength	6.25378
Maximum Path Strength	19.485
Minimum Path Correlation	0.7
Average Path Correlation	0.937914
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	49.8024
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.0131
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • regulation of biological process • cell population proliferation • regulation of cellular process • positive regulation of cell population proliferation • biological regulation • positive regulation of biological process • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • cellular process • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • cellular response to stimulus • positive regulation of cell communication • positive regulation of signal transduction • response to stimulus • signaling • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • multicellular organismal process • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • synapse • cell junction • hippocampal mossy fiber to CA3 synapse • cell body • cilium • ciliary basal body • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide signaling pathway • positive regulation of feeding behavior • feeding behavior • regulation of behavior • behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of feeding behavior • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU9
Sequence	>9KFK_nogp_Chain_R F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D F H W P F G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M A A G P G T H L S L F W A R I A T L A V W A A A A L V T V P T A V F G V E G E V C G V R L C L L R F P S R Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R Q R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L V P W N S T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E P R Q A L A G T F R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YJ4	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-	Gi2/β1/γ2	3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YJ4 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-		3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-	Gi2/β1/γ2	3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-		3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-	Gi2/β1/γ2	2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-		2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	9KFK	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-	Gi2/β1/γ2	2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFK (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-		2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7

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