psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W97	3.08	Yes	Yes	0	0	7
2	L:L:?1	R:R:F105	5.49	Yes	No	0	0	4
3	L:L:?1	R:R:L118	6.24	Yes	No	0	0	5
4	L:L:?1	R:R:L193	9.98	Yes	Yes	1	0	5
5	L:L:?1	R:R:R194	6.57	Yes	No	0	0	4
6	L:L:?1	R:R:Y204	8.45	Yes	Yes	1	0	5
7	L:L:?1	R:R:Q205	13.19	Yes	Yes	1	0	5
8	L:L:?1	R:R:R208	13.13	Yes	Yes	1	0	5
9	L:L:?1	R:R:F291	5.49	Yes	No	1	0	4
10	L:L:?1	R:R:T295	7.97	Yes	No	0	0	6
11	L:L:?1	R:R:H299	3.48	Yes	No	0	0	7
12	R:R:L36	R:R:R39	6.07	No	No	0	3	4
13	R:R:D104	R:R:R39	19.06	No	No	0	4	4
14	R:R:V42	R:R:Y46	7.57	No	Yes	0	5	8
15	R:R:S101	R:R:V42	6.46	No	No	0	4	5
16	R:R:P292	R:R:V42	3.53	No	No	0	4	5
17	R:R:L94	R:R:Y46	5.86	Yes	Yes	0	8	8
18	R:R:A98	R:R:Y46	4	No	Yes	0	6	8
19	R:R:T295	R:R:Y46	6.24	No	Yes	0	6	8
20	R:R:C296	R:R:Y46	4.03	No	Yes	0	4	8
21	R:R:L48	R:R:V49	4.47	No	No	0	5	7
22	R:R:L94	R:R:V49	2.98	Yes	No	0	8	7
23	R:R:G50	R:R:L94	5.13	No	Yes	0	6	8
24	R:R:G56	R:R:L55	3.42	No	No	0	8	4
25	R:R:D87	R:R:N57	16.16	No	Yes	6	9	9
26	R:R:L88	R:R:N57	6.87	No	Yes	0	7	9
27	R:R:N57	R:R:P306	6.52	Yes	No	6	9	9
28	R:R:A59	R:R:L320	4.73	No	No	0	6	7
29	R:R:A84	R:R:V60	3.39	No	No	0	8	9
30	R:R:C310	R:R:V60	8.54	No	No	0	7	9
31	R:R:F81	R:R:L61	4.87	No	No	0	6	6
32	R:R:L64	R:R:V63	2.98	No	Yes	0	7	7
33	R:R:P316	R:R:V63	7.07	Yes	Yes	0	7	7
34	R:R:A319	R:R:V63	3.39	No	Yes	0	5	7
35	R:R:D77	R:R:L64	4.07	No	No	0	7	7
36	R:R:G73	R:R:P74	4.06	No	No	0	6	7
37	R:R:D77	R:R:P74	9.66	No	No	0	7	7
38	R:R:D77	R:R:V80	4.38	No	No	0	7	8
39	R:R:A158	R:R:T78	5.03	No	No	0	8	6
40	R:R:R159	R:R:T78	11.64	No	No	0	4	6
41	R:R:A134	R:R:F79	4.16	No	Yes	0	7	7
42	R:R:F81	R:R:N82	6.04	No	No	0	6	9
43	R:R:N82	R:R:T162	11.7	No	No	0	9	6
44	R:R:L131	R:R:L83	5.54	No	No	0	8	9
45	R:R:D87	R:R:S302	5.89	No	No	0	9	8
46	R:R:D87	R:R:P306	6.44	No	No	6	9	9
47	R:R:G89	R:R:N124	5.09	No	No	0	7	8
48	R:R:L90	R:R:T93	4.42	Yes	No	7	7	6
49	R:R:L90	R:R:T121	4.42	Yes	No	7	7	6
50	R:R:L90	R:R:N124	6.87	Yes	No	0	7	8
51	R:R:L90	R:R:V125	2.98	Yes	No	0	7	7
52	R:R:H299	R:R:L90	7.71	No	Yes	0	7	7
53	R:R:T121	R:R:T93	6.28	No	No	7	6	6
54	R:R:H299	R:R:L94	7.71	No	Yes	0	7	8
55	R:R:F96	R:R:V117	7.87	No	No	0	6	5
56	R:R:E100	R:R:W97	5.45	No	Yes	0	5	7
57	R:R:V117	R:R:W97	4.9	No	Yes	0	5	7
58	R:R:T121	R:R:W97	7.28	No	Yes	0	6	7
59	R:R:E100	R:R:F105	9.33	No	No	0	5	4
60	R:R:E100	R:R:W107	6.54	No	Yes	0	5	9
61	R:R:H106	R:R:V188	11.07	No	No	0	4	3
62	R:R:F109	R:R:W107	14.03	No	Yes	0	7	9
63	R:R:C114	R:R:W107	9.14	No	Yes	5	9	9
64	R:R:V117	R:R:W107	7.36	No	Yes	0	5	9
65	R:R:E182	R:R:W107	7.63	Yes	Yes	5	4	9
66	R:R:C191	R:R:W107	15.67	No	Yes	5	9	9
67	R:R:F109	R:R:P108	5.78	No	No	0	7	3
68	R:R:E182	R:R:G111	3.27	Yes	No	0	4	3
69	R:R:C114	R:R:E182	6.08	No	Yes	5	9	4
70	R:R:C114	R:R:C191	7.28	No	No	5	9	9
71	R:R:K115	R:R:V178	3.04	No	No	0	7	4
72	R:R:L118	R:R:V122	2.98	No	No	0	5	4
73	R:R:A177	R:R:T119	5.03	No	No	0	4	6
74	R:R:T173	R:R:V122	4.76	Yes	No	0	7	4
75	R:R:T176	R:R:V122	9.52	No	No	0	4	4
76	R:R:L123	R:R:W166	6.83	No	Yes	0	5	9
77	R:R:L123	R:R:T173	8.84	No	Yes	0	5	7
78	R:R:V125	R:R:W259	3.68	No	Yes	0	7	9
79	R:R:F130	R:R:Y126	7.22	No	Yes	3	6	7
80	R:R:V172	R:R:Y126	6.31	No	Yes	3	4	7
81	R:R:T173	R:R:Y126	4.99	Yes	Yes	0	7	7
82	R:R:Q207	R:R:Y126	4.51	No	Yes	3	2	7
83	R:R:L211	R:R:Y126	4.69	Yes	Yes	3	4	7
84	R:R:A127	R:R:W166	7.78	No	Yes	0	7	9
85	R:R:I129	R:R:P216	3.39	No	No	0	8	9
86	R:R:I129	R:R:W259	8.22	No	Yes	0	8	9
87	R:R:F130	R:R:L211	3.65	No	Yes	3	6	4
88	R:R:L131	R:R:V165	7.45	No	No	0	8	7
89	R:R:I132	R:R:N305	4.25	No	No	0	8	9
90	R:R:I132	R:R:Y309	8.46	No	Yes	0	8	9
91	R:R:P216	R:R:T133	3.5	No	No	0	9	7
92	R:R:T133	R:R:V219	4.76	No	No	0	7	6
93	R:R:I220	R:R:T133	3.04	Yes	No	0	8	7
94	R:R:L135	R:R:R139	8.5	No	No	2	8	9
95	R:R:L135	R:R:Y309	5.86	No	Yes	2	8	9
96	R:R:I220	R:R:S136	4.64	Yes	Yes	0	8	9
97	R:R:S136	R:R:S223	6.52	Yes	No	0	9	7
98	R:R:S136	R:R:Y224	5.09	Yes	Yes	0	9	9
99	R:R:R139	R:R:Y224	8.23	No	Yes	0	9	9
100	R:R:R139	R:R:Y309	4.12	No	Yes	2	9	9
101	R:R:A144	R:R:Y140	4	No	Yes	0	7	7
102	R:R:M145	R:R:Y140	3.59	No	Yes	0	5	7
103	R:R:S223	R:R:Y140	3.82	No	Yes	0	7	7
104	R:R:L226	R:R:Y140	8.21	No	Yes	0	4	7
105	R:R:M145	R:R:W141	5.82	No	No	0	5	5
106	R:R:L153	R:R:W141	3.42	No	No	0	7	5
107	R:R:L227	R:R:V143	5.96	No	No	0	8	8
108	R:R:A144	R:R:F230	9.71	No	No	0	7	5
109	R:R:A146	R:R:H152	8.78	No	No	0	8	3
110	R:R:G148	R:R:P149	4.06	No	No	0	5	5
111	R:R:S154	R:R:W157	7.41	No	No	0	5	3
112	R:R:F156	R:R:I160	12.56	No	No	0	4	3
113	R:R:I160	R:R:W157	9.4	No	No	0	3	3
114	R:R:T162	R:R:V165	3.17	No	No	0	6	7
115	R:R:Q207	R:R:V172	4.3	No	No	3	2	4
116	R:R:L211	R:R:V172	2.98	Yes	No	3	4	4
117	R:R:P175	R:R:V174	3.53	No	No	0	9	4
118	R:R:T176	R:R:Y204	11.24	No	Yes	0	4	5
119	R:R:F179	R:R:V178	5.24	Yes	No	0	4	4
120	R:R:F179	R:R:F195	6.43	Yes	No	0	4	4
121	R:R:F179	R:R:W200	3.01	Yes	No	0	4	2
122	R:R:F195	R:R:V181	11.8	No	No	0	4	4
123	R:R:E182	R:R:R189	4.65	Yes	No	0	4	4
124	R:R:E184	R:R:G183	3.27	No	No	0	2	1
125	R:R:G183	R:R:L192	5.13	No	Yes	0	1	3
126	R:R:E184	R:R:G187	3.27	No	No	0	2	5
127	R:R:C186	R:R:V185	3.42	No	No	0	2	2
128	R:R:L192	R:R:V185	2.98	Yes	No	0	3	2
129	R:R:L190	R:R:L192	4.15	No	Yes	0	3	3
130	R:R:L192	R:R:R194	8.5	Yes	No	0	3	4
131	R:R:L193	R:R:Y204	4.69	Yes	Yes	1	5	5
132	R:R:S197	R:R:W200	23.47	No	No	0	2	2
133	R:R:R198	R:R:Y199	10.29	No	No	0	2	1
134	R:R:F274	R:R:G202	3.01	No	No	0	3	3
135	R:R:Q205	R:R:Y204	6.76	Yes	Yes	1	5	5
136	R:R:Q205	R:R:R208	3.5	Yes	Yes	1	5	5
137	R:R:Q205	R:R:T266	7.09	Yes	No	1	5	5
138	R:R:Q205	R:R:V270	7.16	Yes	No	0	5	6
139	R:R:L211	R:R:Q207	6.65	Yes	No	3	4	2
140	R:R:N262	R:R:R208	6.03	No	Yes	0	7	5
141	R:R:H263	R:R:R208	4.51	Yes	Yes	0	8	5
142	R:R:R208	R:R:T266	3.88	Yes	No	1	5	5
143	R:R:H263	R:R:V209	4.15	Yes	No	0	8	5
144	R:R:M214	R:R:V210	3.04	No	No	0	4	5
145	R:R:F213	R:R:F256	5.36	No	No	9	9	5
146	R:R:F213	R:R:F260	9.65	No	Yes	9	9	6
147	R:R:F213	R:R:H263	3.39	No	Yes	0	9	8
148	R:R:P216	R:R:V215	3.53	No	No	0	9	5
149	R:R:F255	R:R:L217	3.65	No	No	0	9	5
150	R:R:F256	R:R:L217	4.87	No	No	0	5	5
151	R:R:F255	R:R:I220	5.02	No	Yes	0	9	8
152	R:R:T221	R:R:V252	3.17	No	No	0	4	8
153	R:R:V248	R:R:Y224	11.36	No	Yes	0	7	9
154	R:R:L251	R:R:Y224	3.52	Yes	Yes	0	8	9
155	R:R:L228	R:R:V244	4.47	Yes	No	0	4	7
156	R:R:A245	R:R:L228	3.15	No	Yes	0	5	4
157	R:R:L228	R:R:V248	2.98	Yes	No	0	4	7
158	R:R:F230	R:R:R234	7.48	No	No	0	5	5
159	R:R:L231	R:R:V244	4.47	No	No	0	8	7
160	R:R:R234	R:R:R237	3.2	No	No	0	5	3
161	R:R:Q235	R:R:R236	4.67	No	No	0	4	3
162	R:R:D240	R:R:R237	11.91	No	No	0	5	3
163	R:R:R246	R:R:R249	5.33	No	No	0	6	4
164	R:R:R249	R:R:V252	3.92	No	No	0	4	8
165	R:R:A253	R:R:R249	4.15	No	No	0	4	4
166	R:R:L251	R:R:L308	6.92	Yes	No	2	8	8
167	R:R:L251	R:R:Y309	8.21	Yes	Yes	2	8	9
168	R:R:L304	R:R:S254	3	No	No	0	6	6
169	R:R:L308	R:R:S254	3	No	No	0	8	6
170	R:R:F255	R:R:W259	5.01	No	Yes	0	9	9
171	R:R:F256	R:R:F260	11.79	No	Yes	9	5	6
172	R:R:C258	R:R:N301	3.15	No	Yes	0	7	9
173	R:R:H263	R:R:W259	3.17	Yes	Yes	0	8	9
174	R:R:A298	R:R:W259	3.89	No	Yes	0	8	9
175	R:R:N301	R:R:W259	5.65	Yes	Yes	0	9	9
176	R:R:L297	R:R:P261	3.28	No	No	0	7	9
177	R:R:N262	R:R:T294	5.85	No	Yes	0	7	7
178	R:R:A298	R:R:N262	3.13	No	No	0	8	7
179	R:R:I286	R:R:V265	4.61	Yes	No	0	2	4
180	R:R:F291	R:R:V265	6.55	No	No	1	4	4
181	R:R:T294	R:R:V265	4.76	Yes	No	1	7	4
182	R:R:F283	R:R:W268	5.01	Yes	No	0	1	4
183	R:R:I286	R:R:W268	3.52	Yes	No	0	2	4
184	R:R:G269	R:R:V272	3.68	No	No	0	4	3
185	R:R:L271	R:R:L276	4.15	No	No	0	4	1
186	R:R:L276	R:R:V272	2.98	No	No	4	1	3
187	R:R:F283	R:R:V272	13.11	Yes	No	4	1	3
188	R:R:F283	R:R:L276	6.09	Yes	No	4	1	1
189	R:R:P278	R:R:V277	3.53	No	No	0	3	1
190	R:R:T282	R:R:V277	3.17	No	No	4	3	1
191	R:R:F283	R:R:V277	3.93	Yes	No	4	1	1
192	R:R:N280	R:R:P278	6.52	No	No	0	4	3
193	R:R:F283	R:R:W279	7.02	Yes	No	0	1	1
194	R:R:W279	R:R:Y284	8.68	No	No	0	1	3
195	R:R:S281	R:R:T285	3.2	No	No	0	7	3
196	R:R:F283	R:R:T282	6.49	Yes	No	4	1	3
197	R:R:F283	R:R:Q287	4.68	Yes	No	0	1	3
198	R:R:I286	R:R:Q287	6.86	Yes	No	0	2	3
199	R:R:I286	R:R:V290	4.61	Yes	No	0	2	5
200	R:R:T288	R:R:Y289	4.99	No	No	0	4	1
201	R:R:V290	R:R:V293	3.21	No	No	0	5	5
202	R:R:T294	R:R:V290	3.17	Yes	No	0	7	5
203	R:R:F291	R:R:T294	5.19	No	Yes	1	4	7
204	R:R:C303	R:R:S300	3.44	No	No	0	6	5
205	R:R:L304	R:R:S300	3	No	No	0	6	5
206	R:R:N301	R:R:N305	14.98	Yes	No	8	9	9
207	R:R:L311	R:R:V307	8.94	No	No	0	6	6
208	R:R:C310	R:R:P316	3.77	No	Yes	0	7	7
209	R:R:P316	R:R:R313	10.09	Yes	No	0	7	8
210	R:R:Q318	R:R:R314	4.67	No	No	0	4	5
211	R:R:E315	R:R:P316	9.43	No	Yes	0	6	7
212	R:R:L225	R:R:T221	2.95	No	No	0	3	4
213	R:R:L226	R:R:T222	2.95	No	No	0	4	4
214	R:R:A212	R:R:H263	2.93	No	Yes	0	6	8
215	R:R:F260	R:R:P261	2.89	Yes	No	0	6	9
216	R:R:I132	R:R:L83	2.85	No	No	0	8	9
217	R:R:A161	R:R:F79	2.77	No	Yes	0	5	7
218	R:R:F260	R:R:V264	2.62	Yes	No	0	6	5
219	R:R:F79	R:R:T78	2.59	Yes	No	0	7	6
220	R:R:A86	R:R:W166	2.59	No	Yes	0	8	9
221	R:R:D104	R:R:H106	2.52	No	No	0	4	4
222	R:R:F79	R:R:L131	2.44	Yes	No	0	7	8
223	R:R:F79	R:R:L135	2.44	Yes	No	0	7	8
224	R:R:F109	R:R:L113	2.44	No	No	0	7	6
225	R:R:F179	R:R:L193	2.44	Yes	Yes	0	4	5
226	R:R:L155	R:R:R159	2.43	No	No	0	3	4
227	R:R:F230	R:R:R233	2.14	No	No	0	5	5
228	R:R:G110	R:R:G111	2.11	No	No	0	8	3
229	R:R:G150	R:R:P149	2.03	No	No	0	5	5
230	R:R:C303	R:R:G53	1.96	No	Yes	0	6	9
231	R:R:A91	R:R:G53	1.95	No	Yes	0	6	9
232	R:R:A59	R:R:G56	1.95	No	No	0	6	8
233	R:R:P74	R:R:P75	1.95	No	No	0	7	7
234	R:R:A321	R:R:G322	1.95	No	No	0	3	4
235	R:R:G180	R:R:V181	1.84	No	No	0	5	4
236	R:R:G202	R:R:V270	1.84	No	No	0	3	6
237	R:R:G218	R:R:T222	1.82	No	No	0	2	4
238	R:R:A45	R:R:C296	1.81	No	No	0	4	4
239	R:R:A102	R:R:A43	1.79	No	No	0	3	6
240	R:R:A127	R:R:A169	1.79	No	No	0	7	8
241	R:R:P306	R:R:V60	1.77	No	No	0	9	9
242	R:R:G53	R:R:I52	1.76	Yes	No	0	9	5
243	R:R:P75	R:R:T151	1.75	No	No	0	7	5
244	R:R:G89	R:R:L92	1.71	No	No	0	7	5
245	R:R:G53	R:R:N57	1.7	Yes	Yes	0	9	9
246	R:R:A144	R:R:V143	1.7	No	No	0	7	8
247	R:R:A120	R:R:T93	1.68	No	No	0	4	6
248	R:R:A170	R:R:T173	1.68	No	Yes	0	3	7
249	R:R:L94	R:R:P95	1.64	Yes	No	0	8	9
250	R:R:S136	R:R:V137	1.62	Yes	No	0	9	6
251	R:R:V243	R:R:V244	1.6	No	No	0	7	7
252	R:R:G148	R:R:H152	1.59	No	No	0	5	3
253	R:R:A138	R:R:L153	1.58	No	No	0	8	7
254	R:R:I220	R:R:V252	1.54	Yes	No	0	8	8
255	R:R:L228	R:R:S241	1.5	Yes	No	0	4	7
256	R:R:L251	R:R:S247	1.5	Yes	No	0	8	7
257	R:R:L320	R:R:V63	1.49	No	Yes	0	7	7
258	R:R:N301	R:R:S128	1.49	Yes	No	8	9	9
259	R:R:N305	R:R:S128	1.49	No	No	8	9	9
260	R:R:L153	R:R:V142	1.49	No	No	0	7	8
261	R:R:L190	R:R:V188	1.49	No	No	0	3	3
262	R:R:L206	R:R:V209	1.49	No	No	0	4	5
263	R:R:L211	R:R:V210	1.49	Yes	No	0	4	5
264	R:R:L267	R:R:V270	1.49	No	No	0	5	6
265	R:R:L304	R:R:V307	1.49	No	No	0	6	6
266	R:R:L312	R:R:V307	1.49	No	No	0	6	6
267	R:R:L163	R:R:T162	1.47	No	No	0	3	6
268	R:R:G47	R:R:Y46	1.45	No	Yes	0	5	8
269	R:R:F195	R:R:P196	1.44	No	No	0	4	5
270	R:R:I250	R:R:L251	1.43	No	Yes	2	5	8
271	R:R:I250	R:R:L308	1.43	No	No	2	5	8
272	R:R:L38	R:R:M41	1.41	No	No	0	4	4
273	R:R:K273	R:R:L201	1.41	No	No	0	3	4
274	R:R:H152	R:R:V142	1.38	No	No	0	3	8
275	R:R:L193	R:R:L201	1.38	Yes	No	0	5	4
276	R:R:A229	R:R:R233	1.38	No	No	0	3	5
277	R:R:A321	R:R:R317	1.38	No	No	0	3	9
278	R:R:F79	R:R:S76	1.32	Yes	No	0	7	8
279	R:R:A203	R:R:W200	1.3	No	No	0	4	2
280	R:R:H106	R:R:L103	1.29	No	No	0	4	4
281	R:R:T288	R:R:Y284	1.25	No	No	0	4	3
282	R:R:T285	R:R:Y289	1.25	No	No	0	3	1
283	R:R:L85	R:R:W166	1.14	No	Yes	0	5	9
284	R:R:F274	R:R:Y199	1.03	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.55182	11	1	0
2	R:R:Y46	4.85833	6	0	8
3	R:R:G53	1.8425	4	0	9
4	R:R:N57	7.8125	4	6	9
5	R:R:V63	3.7325	4	0	7
6	R:R:F79	2.62	6	0	7
7	R:R:L90	5.28	5	7	7
8	R:R:L94	4.664	5	0	8
9	R:R:W97	5.1775	4	0	7
10	R:R:W107	10.0617	6	5	9
11	R:R:Y126	5.544	5	3	7
12	R:R:S136	4.4675	4	0	9
13	R:R:Y140	4.905	4	0	7
14	R:R:W166	4.585	4	0	9
15	R:R:T173	5.0675	4	0	7
16	R:R:F179	4.28	4	0	4
17	R:R:E182	5.4075	4	5	4
18	R:R:L192	5.19	4	0	3
19	R:R:L193	4.6225	4	1	5
20	R:R:Y204	7.785	4	1	5
21	R:R:Q205	7.54	5	1	5
22	R:R:R208	6.21	5	1	5
23	R:R:L211	3.892	5	3	4
24	R:R:I220	3.56	4	0	8
25	R:R:Y224	7.05	4	0	9
26	R:R:L228	3.025	4	0	4
27	R:R:L251	4.316	5	2	8
28	R:R:W259	4.93667	6	0	9
29	R:R:F260	6.7375	4	9	6
30	R:R:H263	3.63	5	0	8
31	R:R:F283	6.61857	7	4	1
32	R:R:I286	4.9	4	0	2
33	R:R:T294	4.7425	4	1	7
34	R:R:N301	6.3175	4	8	9
35	R:R:Y309	6.6625	4	2	9
36	R:R:P316	7.59	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R194	22.3556	6.57	Yes	No	0	0	4
2	R:R:L192	R:R:R194	20.9862	8.5	Yes	No	0	3	4
3	R:R:L190	R:R:L192	11.5125	4.15	No	Yes	0	3	3
4	L:L:?1	R:R:T295	13.8068	7.97	Yes	No	0	0	6
5	R:R:T295	R:R:Y46	12.3659	6.24	No	Yes	0	6	8
6	R:R:H299	R:R:L94	14.9004	7.71	No	Yes	0	7	8
7	L:L:?1	R:R:R208	84.8493	13.13	Yes	Yes	1	0	5
8	R:R:H263	R:R:R208	95.7179	4.51	Yes	Yes	0	8	5
9	R:R:H263	R:R:W259	89.4992	3.17	Yes	Yes	0	8	9
10	R:R:F255	R:R:W259	98.9116	5.01	No	Yes	0	9	9
11	R:R:F255	R:R:I220	100	5.02	No	Yes	0	9	8
12	R:R:I220	R:R:S136	94.3587	4.64	Yes	Yes	0	8	9
13	R:R:S136	R:R:Y224	70.2555	5.09	Yes	Yes	0	9	9
14	R:R:L251	R:R:Y224	55.8559	3.52	Yes	Yes	0	8	9
15	R:R:L251	R:R:L308	97.5677	6.92	Yes	No	2	8	8
16	R:R:L308	R:R:S254	95.2632	3	No	No	0	8	6
17	R:R:L304	R:R:S254	92.6316	3	No	No	0	6	6
18	R:R:L304	R:R:S300	81.9622	3	No	No	0	6	5
19	R:R:C303	R:R:S300	79.2693	3.44	No	No	0	6	5
20	R:R:C303	R:R:G53	76.5662	1.96	No	Yes	0	6	9
21	R:R:G53	R:R:N57	68.3955	1.7	Yes	Yes	0	9	9
22	R:R:N57	R:R:P306	57.1538	6.52	Yes	No	6	9	9
23	R:R:P306	R:R:V60	54.5733	1.77	No	No	0	9	9
24	R:R:C310	R:R:V60	48.9729	8.54	No	No	0	7	9
25	R:R:C310	R:R:P316	46.1574	3.77	No	Yes	0	7	7
26	R:R:P316	R:R:V63	37.6495	7.07	Yes	Yes	0	7	7
27	R:R:L320	R:R:V63	11.8498	1.49	No	Yes	0	7	7
28	R:R:N301	R:R:W259	83.7864	5.65	Yes	Yes	0	9	9
29	R:R:N301	R:R:N305	80.3066	14.98	Yes	No	8	9	9
30	R:R:I132	R:R:N305	79.9847	4.25	No	No	0	8	9
31	R:R:I132	R:R:Y309	61.6096	8.46	No	Yes	0	8	9
32	R:R:L251	R:R:Y309	51.211	8.21	Yes	Yes	2	8	9
33	R:R:I132	R:R:L83	21.8804	2.85	No	No	0	8	9
34	R:R:L131	R:R:L83	20.0051	5.54	No	No	0	8	9
35	R:R:L131	R:R:V165	11.5841	7.45	No	No	0	8	7
36	R:R:L64	R:R:V63	20.3577	2.98	No	Yes	0	7	7
37	R:R:D77	R:R:L64	17.44	4.07	No	No	0	7	7
38	R:R:D77	R:R:P74	11.5738	9.66	No	No	0	7	7
39	R:R:L135	R:R:Y309	14.1594	5.86	No	Yes	2	8	9
40	R:R:F79	R:R:L135	16.5764	2.44	Yes	No	0	7	8
41	R:R:F79	R:R:T78	11.9111	2.59	Yes	No	0	7	6
42	R:R:F79	R:R:L131	13.1017	2.44	Yes	No	0	7	8
43	R:R:H299	R:R:L90	15.5135	7.71	No	Yes	0	7	7
44	L:L:?1	R:R:W97	35.7077	3.08	Yes	Yes	0	0	7
45	R:R:T121	R:R:W97	21.9162	7.28	No	Yes	0	6	7
46	R:R:L90	R:R:V125	37.7874	2.98	Yes	No	0	7	7
47	R:R:V117	R:R:W97	27.2713	4.9	No	Yes	0	5	7
48	R:R:E100	R:R:W97	25.442	5.45	No	Yes	0	5	7
49	L:L:?1	R:R:F105	17.4144	5.49	Yes	No	0	0	4
50	R:R:E100	R:R:F105	15.999	9.33	No	No	0	5	4
51	R:R:E100	R:R:W107	37.675	6.54	No	Yes	0	5	9
52	R:R:F109	R:R:W107	18.3597	14.03	No	Yes	0	7	9
53	R:R:V117	R:R:W107	22.9739	7.36	No	Yes	0	5	9
54	R:R:E182	R:R:W107	24.4405	7.63	Yes	Yes	5	4	9
55	R:R:E182	R:R:G111	12.2586	3.27	Yes	No	0	4	3
56	L:L:?1	R:R:L193	20.2146	9.98	Yes	Yes	1	0	5
57	R:R:F179	R:R:L193	17.3531	2.44	Yes	Yes	0	4	5
58	L:L:?1	R:R:L118	26.5713	6.24	Yes	No	0	0	5
59	R:R:L118	R:R:V122	25.2274	2.98	No	No	0	5	4
60	R:R:T173	R:R:V122	25.5749	4.76	Yes	No	0	7	4
61	R:R:L123	R:R:T173	10.5416	8.84	No	Yes	0	5	7
62	R:R:T173	R:R:Y126	12.1666	4.99	Yes	Yes	0	7	7
63	R:R:S136	R:R:S223	39.816	6.52	Yes	No	0	9	7
64	R:R:S223	R:R:Y140	38.2626	3.82	No	Yes	0	7	7
65	R:R:A144	R:R:Y140	15.5953	4	No	Yes	0	7	7
66	R:R:M145	R:R:Y140	17.256	3.59	No	Yes	0	5	7
67	R:R:M145	R:R:W141	15.5595	5.82	No	No	0	5	5
68	R:R:L153	R:R:W141	13.8426	3.42	No	No	0	7	5
69	R:R:L153	R:R:V142	10.5621	1.49	No	No	0	7	8
70	R:R:Q205	R:R:V270	10.7052	7.16	Yes	No	0	5	6
71	R:R:I220	R:R:V252	10.5723	1.54	Yes	No	0	8	8
72	R:R:V248	R:R:Y224	12.1155	11.36	No	Yes	0	7	9
73	R:R:L228	R:R:V248	10.511	2.98	Yes	No	0	4	7
74	R:R:A144	R:R:F230	10.4394	9.71	No	No	0	7	5
75	R:R:A298	R:R:N262	59.8109	3.13	No	No	0	8	7
76	L:L:?1	R:R:F291	24.8799	5.49	Yes	No	1	0	4
77	R:R:F291	R:R:V265	21.9877	6.55	No	No	1	4	4
78	R:R:I286	R:R:V265	51.0935	4.61	Yes	No	0	2	4
79	R:R:I286	R:R:W268	39.581	3.52	Yes	No	0	2	4
80	R:R:F283	R:R:W268	37.2305	5.01	Yes	No	0	1	4
81	R:R:I286	R:R:Q287	39.1926	6.86	Yes	No	0	2	3
82	R:R:F283	R:R:Q287	36.7757	4.68	Yes	No	0	1	3
83	R:R:F283	R:R:V277	15.0639	3.93	Yes	No	4	1	1
84	R:R:P278	R:R:V277	10.0613	3.53	No	No	0	3	1
85	R:R:F283	R:R:W279	30.0715	7.02	Yes	No	0	1	1
86	R:R:W279	R:R:Y284	25.0843	8.68	No	No	0	1	3
87	R:R:T288	R:R:Y284	20.0869	1.25	No	No	0	4	3
88	R:R:T288	R:R:Y289	15.0792	4.99	No	No	0	4	1
89	R:R:T285	R:R:Y289	10.0613	1.25	No	No	0	3	1
90	R:R:T294	R:R:V290	32.5447	3.17	Yes	No	0	7	5
91	R:R:V125	R:R:W259	38.3802	3.68	No	Yes	0	7	9
92	R:R:L90	R:R:T121	21.022	4.42	Yes	No	7	7	6
93	R:R:N262	R:R:T294	63.1579	5.85	No	Yes	0	7	7
94	R:R:T294	R:R:V265	30.3986	4.76	Yes	No	1	7	4
95	R:R:I286	R:R:V290	29.8365	4.61	Yes	No	0	2	5
96	R:R:A298	R:R:W259	59.8314	3.89	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W97	3.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F105	5.49	1	Yes	No	0	4	0	1
L:L:?1	R:R:L118	6.24	1	Yes	No	0	5	0	1
L:L:?1	R:R:L193	9.98	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R194	6.57	1	Yes	No	0	4	0	1
L:L:?1	R:R:Y204	8.45	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Q205	13.19	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R208	13.13	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:F291	5.49	1	Yes	No	0	4	0	1
L:L:?1	R:R:T295	7.97	1	Yes	No	0	6	0	1
L:L:?1	R:R:H299	3.48	1	Yes	No	0	7	0	1
R:R:L94	R:R:Y46	5.86	0	Yes	Yes	8	8	2	2
R:R:T295	R:R:Y46	6.24	0	No	Yes	6	8	1	2
R:R:L90	R:R:T121	4.42	7	Yes	No	7	6	2	2
R:R:H299	R:R:L90	7.71	0	No	Yes	7	7	1	2
R:R:H299	R:R:L94	7.71	0	No	Yes	7	8	1	2
R:R:E100	R:R:W97	5.45	0	No	Yes	5	7	2	1
R:R:V117	R:R:W97	4.9	0	No	Yes	5	7	2	1
R:R:T121	R:R:W97	7.28	7	No	Yes	6	7	2	1
R:R:E100	R:R:F105	9.33	0	No	No	5	4	2	1
R:R:L118	R:R:V122	2.98	0	No	No	5	4	1	2
R:R:T176	R:R:V122	9.52	0	No	No	4	4	2	2
R:R:T176	R:R:Y204	11.24	0	No	Yes	4	5	2	1
R:R:L192	R:R:R194	8.5	0	Yes	No	3	4	2	1
R:R:L193	R:R:Y204	4.69	1	Yes	Yes	5	5	1	1
R:R:Q205	R:R:Y204	6.76	1	Yes	Yes	5	5	1	1
R:R:Q205	R:R:R208	3.5	1	Yes	Yes	5	5	1	1
R:R:Q205	R:R:T266	7.09	1	Yes	No	5	5	1	2
R:R:Q205	R:R:V270	7.16	1	Yes	No	5	6	1	2
R:R:N262	R:R:R208	6.03	0	No	Yes	7	5	2	1
R:R:H263	R:R:R208	4.51	0	Yes	Yes	8	5	2	1
R:R:R208	R:R:T266	3.88	1	Yes	No	5	5	1	2
R:R:N262	R:R:T294	5.85	0	No	Yes	7	7	2	2
R:R:F291	R:R:V265	6.55	1	No	No	4	4	1	2
R:R:T294	R:R:V265	4.76	1	Yes	No	7	4	2	2
R:R:F291	R:R:T294	5.19	1	No	Yes	4	7	1	2
R:R:F179	R:R:L193	2.44	0	Yes	Yes	4	5	2	1
R:R:L193	R:R:L201	1.38	1	Yes	No	5	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7YK7_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	259
Number of Links	284
Number of Hubs	36
Number of Links mediated by Hubs	148
Number of Communities	9
Number of Nodes involved in Communities	41
Number of Links involved in Communities	51

Path Summary
Number Of Nodes in MetaPath	97
Number Of Links MetaPath	96
Number of Shortest Paths	57737
Length Of Smallest Path	3
Average Path Length	15.0034
Length of Longest Path	36
Minimum Path Strength	1.435
Average Path Strength	5.37216
Maximum Path Strength	14.85
Minimum Path Correlation	0.7
Average Path Correlation	0.924571
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.22581
Average % Of Corr. Nodes	43.9024
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.597
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • positive regulation of feeding behavior • multicellular organismal process • positive regulation of biological process • feeding behavior • regulation of behavior • behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of feeding behavior • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cell population proliferation • positive regulation of cell population proliferation • positive regulation of neural precursor cell proliferation • regulation of cell population proliferation • neural precursor cell proliferation • positive regulation of cellular process • regulation of neural precursor cell proliferation • reactive oxygen species metabolic process • regulation of superoxide metabolic process • positive regulation of reactive oxygen species metabolic process • superoxide metabolic process • positive regulation of metabolic process • superoxide anion generation • metabolic process • positive regulation of superoxide anion generation • regulation of superoxide anion generation • regulation of metabolic process • regulation of reactive oxygen species metabolic process • regulation of calcium ion transport • regulation of localization • transport • regulation of transport • regulation of monoatomic ion transport • establishment of localization • metal ion transport • calcium ion transport • localization • monoatomic ion transport • regulation of metal ion transport • monoatomic cation transport • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • negative regulation of signaling • negative regulation of biological process • negative regulation of G protein-coupled receptor signaling pathway • negative regulation of cell communication • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • negative regulation of cellular process • regulation of G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • negative regulation of response to stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • negative regulation of signal transduction • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell division • regulation of body fluid levels • renal system process • system process • positive regulation of urine volume • regulation of urine volume • regulation of biological quality • regulation of vascular associated smooth muscle cell proliferation • positive regulation of vascular associated smooth muscle cell proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • positive regulation of smooth muscle cell proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cell-cell signaling • gamma-aminobutyric acid signaling pathway • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic receptor signaling pathway • G protein-coupled adenosine receptor signaling pathway • regulation of molecular function • regulation of adenylate cyclase activity • regulation of catalytic activity • negative regulation of molecular function • negative regulation of catalytic activity • negative regulation of adenylate cyclase activity • regulated exocytosis • regulation of calcium ion-dependent exocytosis • negative regulation of transport • negative regulation of regulated secretory pathway • vesicle-mediated transport • regulation of regulated secretory pathway • secretion by cell • regulation of secretion by cell • negative regulation of secretion • negative regulation of exocytosis • negative regulation of secretion by cell • calcium-ion regulated exocytosis • secretion • negative regulation of calcium ion-dependent exocytosis • export from cell • regulation of vesicle-mediated transport • regulation of secretion • exocytosis • regulation of exocytosis • regulation of programmed cell death • negative regulation of apoptotic signaling pathway • negative regulation of programmed cell death • regulation of apoptotic process • cell death • apoptotic signaling pathway • negative regulation of apoptotic process • apoptotic process • programmed cell death • regulation of apoptotic signaling pathway • positive regulation of locomotion • regulation of cell motility • positive regulation of cell migration • regulation of locomotion • positive regulation of cell motility • regulation of cell migration • cell migration • cell motility • locomotion • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to nitrogen compound • cellular response to acetylcholine • response to oxygen-containing compound • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to chemical • response to acetylcholine • response to nutrient levels • response to nutrient • midbody • dense core granule • intracellular vesicle • endomembrane system • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • centrosome • microtubule organizing center • cytoskeleton • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • somatodendritic compartment • dendrite • dendritic tree • nucleus • membrane-enclosed lumen • intracellular organelle lumen • nucleoplasm • organelle lumen • nuclear lumen • neuron to neuron synapse • hippocampal mossy fiber to CA3 synapse • cell body • ciliary basal body • G-protein beta-subunit binding • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	IYM
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	IYM
Name	[(1S)-7-ethoxy-6-methoxy-1-[2-(5-methoxy-1H-indol-3-yl)ethyl]-3,4-dihydro-1H-isoquinolin-2-yl]-morpholin-4-yl-methanone
Synonyms
Identifier
Formula	C28 H35 N3 O5
Molecular Weight	493.595
SMILES
PubChem	166625060
Formal Charge	0
Total Atoms	71
Total Chiral Atoms	1
Total Bonds	75
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU9
Sequence	>7YK7_nogp_Chain_R F L A L R L M V A L A Y G L V G A I G L L G N L A V L W V L S G P P S D T F V F N L A L A D L G L A L T L P F W A A E S A L D F H W P F G G A L C K M V L T A T V L N V Y A S I F L I T A L S V A R Y W V V A M A A G P G T H L S L F W A R I A T L A V W A A A A L V T V P T A V F G V E G E V C G V R L C L L R F P S R Y W L G A Y Q L Q R V V L A F M V P L G V I T T S Y L L L L A F L Q R R Q R R R Q D S R V V A R S V R I L V A S F F L C W F P N H V V T L W G V L V K F D L V P W N S T F Y T I Q T Y V F P V T T C L A H S N S C L N P V L Y C L L R R E P R Q A L A G T F R D Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7YJ4	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-	Gi2/β1/γ2	3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YJ4 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	INSL5	-		3.19	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-	Gi2/β1/γ2	3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK6 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	PubChem 138319674	-		3.03	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-	Gi2/β1/γ2	2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	7YK7 (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	DC591053	-		2.75	2023-03-01	doi.org/10.1038/s41467-023-36182-z
	9KFK	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-	Gi2/β1/γ2	2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7
	9KFK (No Gprot)	A	Peptide	Relaxin	RXFP4	Homo sapiens	Relaxin-3	-		2.95	2025-08-13	doi.org/10.1038/s42003-025-08220-7

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