Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.5491010
2R:R:Y46 4.546508
3R:R:N57 7.095429
4R:R:V60 5.43429
5R:R:P74 4.0025407
6R:R:N82 6.5125409
7R:R:L83 4.605459
8R:R:L94 3.682508
9R:R:W97 7.21617
10R:R:E100 6.8525415
11R:R:W107 10.0233619
12R:R:F109 7.676517
13R:R:L113 3.46416
14R:R:Y126 7.1125407
15R:R:L153 3.1975407
16R:R:T162 4.2225406
17R:R:E182 5.338514
18R:R:C191 6.855419
19R:R:R198 11.3525432
20R:R:L201 5.64434
21R:R:Y204 4.40833605
22R:R:Y224 8.5125409
23R:R:L251 6.2488
24R:R:F256 7.7575475
25R:R:W259 5.385669
26R:R:F260 7.305476
27R:R:H263 5.93508
28R:R:V272 4.17333643
29R:R:F283 10.396541
30R:R:T294 4.8325407
31R:R:L308 3.1925488
32R:R:L311 5.235426
33R:R:F324 7.14406
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:H299 48.90386YesNo007
2L:L:?1 R:R:R208 81.65784.26YesNo005
3R:R:H263 R:R:R208 89.56244.51YesNo085
4R:R:H263 R:R:W259 1004.23YesYes089
5R:R:N301 R:R:W259 97.52826.78NoYes099
6R:R:N301 R:R:N305 95.746413.62NoNo099
7R:R:I132 R:R:N305 70.52148.5NoNo589
8R:R:I132 R:R:Y309 82.094513.3NoNo089
9R:R:L251 R:R:Y309 78.452310.55YesNo089
10R:R:L251 R:R:L308 19.92315.54YesYes888
11R:R:L308 R:R:S254 11.32853YesNo086
12R:R:H299 R:R:L90 43.65457.71NoNo077
13R:R:L90 R:R:N124 40.82456.87NoNo078
14R:R:G89 R:R:N124 39.40965.09NoNo078
15R:R:G89 R:R:L92 38.09073.42NoNo075
16R:R:L88 R:R:L92 36.86784.15NoNo075
17R:R:L88 R:R:N57 35.67125.49NoYes079
18R:R:N57 R:R:P306 31.66226.52YesNo299
19R:R:P306 R:R:V60 31.02455.3NoYes299
20R:R:L311 R:R:V60 23.49554.47YesYes269
21R:R:L311 R:R:L320 24.98032.77YesNo067
22R:R:F324 R:R:L320 24.220512.18YesNo067
23R:R:F324 R:R:V63 23.32956.55YesNo067
24R:R:L64 R:R:V63 22.14175.96NoNo077
25R:R:D77 R:R:L64 21.643812.21NoNo077
26R:R:D77 R:R:P74 22.35136.44NoYes077
27R:R:L251 R:R:Y224 69.91885.86YesYes089
28R:R:V248 R:R:Y224 62.983712.62NoYes079
29R:R:L228 R:R:V248 61.96172.98NoNo047
30R:R:L228 R:R:V244 60.08382.98NoNo047
31R:R:L231 R:R:V244 24.08074.47NoNo087
32R:R:L231 R:R:V143 21.39051.49NoNo088
33R:R:V142 R:R:V143 41.98621.6NoNo088
34R:R:L153 R:R:V142 38.92921.49YesNo078
35R:R:L153 R:R:P75 30.3526.57YesNo077
36R:R:L227 R:R:V244 35.53151.49NoNo087
37R:R:L227 R:R:V143 23.55664.47NoNo088
38R:R:P74 R:R:P75 25.75771.95YesNo077
39R:R:L83 R:R:N305 24.67465.49YesNo599
40R:R:L131 R:R:L83 33.25184.15NoYes089
41R:R:L131 R:R:N82 31.3044.12NoYes089
42R:R:N82 R:R:T162 17.180510.24YesYes096
43L:L:?1 R:R:E100 26.901910.83YesYes105
44R:R:E100 R:R:W107 27.20763.27YesYes159
45L:L:?1 R:R:W97 14.50787.98YesYes107
46L:L:?1 R:R:F105 16.735115.64YesNo104
47R:R:F105 R:R:L190 16.831213.4NoNo043
48R:R:L190 R:R:V188 14.78732.98NoNo033
49R:R:E182 R:R:W107 10.42895.45YesYes149
50L:L:?1 R:R:V122 19.15453.48YesNo004
51R:R:T176 R:R:V122 17.748312.69NoNo044
52R:R:T176 R:R:Y204 16.21988.74NoYes045
53R:R:R208 R:R:Y126 21.87965.14NoYes057
54R:R:F130 R:R:Y126 10.498.25NoYes067
55R:R:S136 R:R:Y224 17.949211.45NoYes099
56R:R:I220 R:R:S136 11.3464.64NoNo089
57R:R:L227 R:R:Y140 15.99272.34NoNo087
58R:R:A144 R:R:Y140 12.09719.34NoNo077
59R:R:A144 R:R:F230 10.12324.16NoNo075
60R:R:L201 R:R:Y204 16.08873.52YesYes045
61R:R:F213 R:R:H263 60.607912.44NoYes098
62R:R:F213 R:R:F260 54.39787.5NoYes796
63R:R:F260 R:R:P261 52.93044.33YesNo069
64R:R:P261 R:R:T294 49.55893.5NoYes097
65R:R:T294 R:R:V290 42.60633.17YesNo075
66R:R:I286 R:R:V290 40.82454.61NoNo025
67R:R:I286 R:R:Q287 39.02525.49NoNo023
68R:R:F283 R:R:Q287 35.34813.51YesNo013
69R:R:F283 R:R:V272 18.080211.8YesYes413
70R:R:Q205 R:R:Y204 19.7315.64NoYes055
71R:R:H263 R:R:V209 25.7145.54YesNo085
72R:R:T266 R:R:V209 22.20283.17NoNo055
73R:R:F283 R:R:T282 10.55992.59YesNo013
74R:R:Q205 R:R:T266 20.46478.5NoNo055
75R:R:I132 R:R:L83 12.41164.28NoYes589
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:W97 7.98 1 Yes Yes 0 7 0 1
L:L:?1 R:R:E100 10.83 1 Yes Yes 0 5 0 1
L:L:?1 R:R:F105 15.64 1 Yes No 0 4 0 1
L:L:?1 R:R:L118 4.85 1 Yes No 0 5 0 1
L:L:?1 R:R:V122 3.48 1 Yes No 0 4 0 1
L:L:?1 R:R:L192 11.31 1 Yes No 0 3 0 1
L:L:?1 R:R:R194 4.26 1 Yes No 0 4 0 1
L:L:?1 R:R:R208 4.26 1 Yes No 0 5 0 1
L:L:?1 R:R:T295 6.88 1 Yes No 0 6 0 1
L:L:?1 R:R:H299 6 1 Yes No 0 7 0 1
R:R:L94 R:R:Y46 5.86 0 Yes Yes 8 8 2 2
R:R:T295 R:R:Y46 4.99 0 No Yes 6 8 1 2
R:R:H299 R:R:L90 7.71 0 No No 7 7 1 2
R:R:H299 R:R:L94 7.71 0 No Yes 7 8 1 2
R:R:E100 R:R:W97 9.81 1 Yes Yes 5 7 1 1
R:R:V117 R:R:W97 7.36 0 No Yes 5 7 2 1
R:R:L118 R:R:W97 6.83 1 No Yes 5 7 1 1
R:R:T121 R:R:W97 6.06 0 No Yes 6 7 2 1
R:R:C191 R:R:W97 5.22 1 Yes Yes 9 7 2 1
R:R:E100 R:R:F105 3.5 1 Yes No 5 4 1 1
R:R:E100 R:R:W107 3.27 1 Yes Yes 5 9 1 2
R:R:F105 R:R:L190 13.4 1 No No 4 3 1 2
R:R:C191 R:R:W107 11.75 1 Yes Yes 9 9 2 2
R:R:C191 R:R:L118 3.17 1 Yes No 9 5 2 1
R:R:T173 R:R:V122 3.17 0 No No 7 4 2 1
R:R:T176 R:R:V122 12.69 0 No No 4 4 2 1
R:R:T173 R:R:Y126 7.49 0 No Yes 7 7 2 2
R:R:R208 R:R:Y126 5.14 0 No Yes 5 7 1 2
R:R:G183 R:R:L192 3.42 0 No No 1 3 2 1
R:R:L192 R:R:R194 10.93 1 No No 3 4 1 1
R:R:P196 R:R:R194 17.29 0 No No 5 4 2 1
R:R:H263 R:R:R208 4.51 0 Yes No 8 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7YK6_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.17
Number of Linked Nodes 258
Number of Links 274
Number of Hubs 33
Number of Links mediated by Hubs 134
Number of Communities 8
Number of Nodes involved in Communities 43
Number of Links involved in Communities 55
Path Summary
Number Of Nodes in MetaPath 76
Number Of Links MetaPath 75
Number of Shortest Paths 29339
Length Of Smallest Path 3
Average Path Length 13.6595
Length of Longest Path 30
Minimum Path Strength 1.225
Average Path Strength 6.15924
Maximum Path Strength 17.555
Minimum Path Correlation 0.7
Average Path Correlation 0.929405
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 49.4408
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 35.409
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • cell communication   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • neuropeptide signaling pathway   • positive regulation of feeding behavior   • multicellular organismal process   • positive regulation of biological process   • feeding behavior   • regulation of behavior   • behavior   • positive regulation of behavior   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of feeding behavior   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cell population proliferation   • positive regulation of cell population proliferation   • positive regulation of neural precursor cell proliferation   • regulation of cell population proliferation   • neural precursor cell proliferation   • positive regulation of cellular process   • regulation of neural precursor cell proliferation   • reactive oxygen species metabolic process   • regulation of superoxide metabolic process   • positive regulation of reactive oxygen species metabolic process   • superoxide metabolic process   • positive regulation of metabolic process   • superoxide anion generation   • metabolic process   • positive regulation of superoxide anion generation   • regulation of superoxide anion generation   • regulation of metabolic process   • regulation of reactive oxygen species metabolic process   • regulation of calcium ion transport   • regulation of localization   • transport   • regulation of transport   • regulation of monoatomic ion transport   • establishment of localization   • metal ion transport   • calcium ion transport   • localization   • monoatomic ion transport   • regulation of metal ion transport   • monoatomic cation transport   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • negative regulation of signaling   • negative regulation of biological process   • negative regulation of G protein-coupled receptor signaling pathway   • negative regulation of cell communication   • negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • negative regulation of cellular process   • regulation of G protein-coupled receptor signaling pathway   • adenylate cyclase-activating adrenergic receptor signaling pathway   • negative regulation of response to stimulus   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • negative regulation of signal transduction   • negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell division   • regulation of body fluid levels   • renal system process   • system process   • positive regulation of urine volume   • regulation of urine volume   • regulation of biological quality   • regulation of vascular associated smooth muscle cell proliferation   • positive regulation of vascular associated smooth muscle cell proliferation   • regulation of smooth muscle cell proliferation   • smooth muscle cell proliferation   • positive regulation of smooth muscle cell proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • cell-cell signaling   • gamma-aminobutyric acid signaling pathway   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic receptor signaling pathway   • G protein-coupled adenosine receptor signaling pathway   • regulation of molecular function   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • negative regulation of molecular function   • negative regulation of catalytic activity   • negative regulation of adenylate cyclase activity   • regulated exocytosis   • regulation of calcium ion-dependent exocytosis   • negative regulation of transport   • negative regulation of regulated secretory pathway   • vesicle-mediated transport   • regulation of regulated secretory pathway   • secretion by cell   • regulation of secretion by cell   • negative regulation of secretion   • negative regulation of exocytosis   • negative regulation of secretion by cell   • calcium-ion regulated exocytosis   • secretion   • negative regulation of calcium ion-dependent exocytosis   • export from cell   • regulation of vesicle-mediated transport   • regulation of secretion   • exocytosis   • regulation of exocytosis   • regulation of programmed cell death   • negative regulation of apoptotic signaling pathway   • negative regulation of programmed cell death   • regulation of apoptotic process   • cell death   • apoptotic signaling pathway   • negative regulation of apoptotic process   • apoptotic process   • programmed cell death   • regulation of apoptotic signaling pathway   • positive regulation of locomotion   • regulation of cell motility   • positive regulation of cell migration   • regulation of locomotion   • positive regulation of cell motility   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • trans-synaptic signaling   • modulation of chemical synaptic transmission   • negative regulation of synaptic transmission   • chemical synaptic transmission   • synaptic signaling   • regulation of trans-synaptic signaling   • anterograde trans-synaptic signaling   • cellular response to nitrogen compound   • cellular response to acetylcholine   • response to oxygen-containing compound   • response to nitrogen compound   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • G protein-coupled acetylcholine receptor signaling pathway   • response to chemical   • response to acetylcholine   • response to nutrient levels   • response to nutrient   • midbody   • dense core granule   • intracellular vesicle   • endomembrane system   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • neuronal dense core vesicle   • centrosome   • microtubule organizing center   • cytoskeleton   • membraneless organelle   • intracellular membraneless organelle   • microtubule cytoskeleton   • somatodendritic compartment   • dendrite   • dendritic tree   • nucleus   • membrane-enclosed lumen   • intracellular organelle lumen   • nucleoplasm   • organelle lumen   • nuclear lumen   • neuron to neuron synapse   • hippocampal mossy fiber to CA3 synapse   • cell body   • ciliary basal body   • G-protein beta-subunit binding   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeIYF
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeIYF
Name1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1H-indol-3-yl)methylideneamino]guanidine
Synonyms
Identifier
FormulaC20 H22 Cl N5 O
Molecular Weight383.875
SMILES
PubChem138319674
Formal Charge0
Total Atoms49
Total Chiral Atoms0
Total Bonds51
Total Aromatic Bonds16

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDU9
Sequence
>7YK6_nogp_Chain_R
FLALRLMVA LAYGLVGAI GLLGNLAVL WVLSGPPSD TFVFNLALA 
DLGLALTLP FWAAESALD FHWPFGGAL CKMVLTATV LNVYASIFL 
ITALSVARY WVVAMAAGP GTHLSLFWA RIATLAVWA AAALVTVPT 
AVFGVEGEV CGVRLCLLR FPSRYWLGA YQLQRVVLA FMVPLGVIT 
TSYLLLLAF LQRRQRRRQ DSRVVARSV RILVASFFL CWFPNHVVT 
LWGVLVKFD LVPWNSTFY TIQTYVFPV TTCLAHSNS CLNPVLYCL 
LRREPRQAL AGTFR


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ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YJ4APeptideRelaxinRXFP4Homo sapiensINSL5-Gi2/β1/γ23.192023-03-01doi.org/10.1038/s41467-023-36182-z
7YJ4 (No Gprot) APeptideRelaxinRXFP4Homo sapiensINSL5-3.192023-03-01doi.org/10.1038/s41467-023-36182-z
7YK6APeptideRelaxinRXFP4Homo sapiensPubChem 138319674-Gi2/β1/γ23.032023-03-01doi.org/10.1038/s41467-023-36182-z
7YK6 (No Gprot) APeptideRelaxinRXFP4Homo sapiensPubChem 138319674-3.032023-03-01doi.org/10.1038/s41467-023-36182-z
7YK7APeptideRelaxinRXFP4Homo sapiensDC591053-Gi2/β1/γ22.752023-03-01doi.org/10.1038/s41467-023-36182-z
7YK7 (No Gprot) APeptideRelaxinRXFP4Homo sapiensDC591053-2.752023-03-01doi.org/10.1038/s41467-023-36182-z
9KFKAPeptideRelaxinRXFP4Homo sapiensRelaxin-3-Gi2/β1/γ22.952025-08-13doi.org/10.1038/s42003-025-08220-7
9KFK (No Gprot) APeptideRelaxinRXFP4Homo sapiensRelaxin-3-2.952025-08-13doi.org/10.1038/s42003-025-08220-7




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Download 7YK6_nogp.zip



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