psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N8	R:R:S10	5.96	No	No	0	5	8
2	R:R:A90	R:R:F9	4.16	No	No	0	4	7
3	R:R:F9	R:R:L161	4.87	No	No	0	7	4
4	R:R:C11	R:R:L84	4.76	No	No	0	5	5
5	R:R:C11	R:R:C166	7.28	No	No	0	5	3
6	R:R:L17	R:R:Y12	5.86	No	No	0	4	8
7	R:R:E14	R:R:H13	7.39	No	No	0	6	6
8	R:R:H13	R:R:S15	4.18	No	No	0	6	8
9	R:R:H13	R:R:R349	4.51	No	No	0	6	1
10	R:R:M353	R:R:V16	6.09	No	No	0	5	6
11	R:R:V22	R:R:Y19	8.83	No	Yes	0	5	5
12	R:R:V350	R:R:Y19	5.05	No	Yes	0	3	5
13	R:R:M353	R:R:Y19	7.18	No	Yes	0	5	5
14	R:R:L354	R:R:Y19	4.69	No	Yes	0	4	5
15	R:R:R20	R:R:Y21	11.32	No	No	0	7	4
16	R:R:L84	R:R:R20	4.86	No	No	0	5	7
17	R:R:A23	R:R:Y81	6.67	No	Yes	0	7	5
18	R:R:L82	R:R:V24	5.96	No	No	0	5	6
19	R:R:V29	R:R:W26	6.13	No	No	0	4	5
20	R:R:V30	R:R:W26	6.13	Yes	No	0	6	5
21	R:R:W26	R:R:W360	8.43	No	Yes	0	5	8
22	R:R:Q74	R:R:V30	7.16	No	Yes	0	8	6
23	R:R:C364	R:R:V30	5.12	No	Yes	0	6	6
24	R:R:C364	R:R:T33	5.07	No	No	0	6	4
25	R:R:T35	R:R:T71	6.28	No	No	0	7	5
26	R:R:G37	R:R:P367	4.06	No	No	0	9	9
27	R:R:N38	R:R:T63	7.31	Yes	No	0	9	9
28	R:R:D66	R:R:N38	13.46	No	Yes	0	9	9
29	R:R:L67	R:R:N38	4.12	No	Yes	0	7	9
30	R:R:N38	R:R:P367	11.4	Yes	No	0	9	9
31	R:R:T41	R:R:T63	10.99	No	No	0	9	9
32	R:R:A371	R:R:T41	5.03	No	No	0	8	9
33	R:R:L42	R:R:L64	5.54	No	No	0	7	6
34	R:R:F377	R:R:L45	7.31	Yes	No	0	9	8
35	R:R:I384	R:R:I47	5.89	No	No	0	7	5
36	R:R:K50	R:R:Q48	14.92	No	Yes	0	6	7
37	R:R:L51	R:R:Q48	5.32	Yes	Yes	0	9	7
38	R:R:Q48	R:R:S383	7.22	Yes	No	0	7	6
39	R:R:P49	R:R:R52	7.21	No	No	0	6	7
40	R:R:L51	R:R:N56	4.12	Yes	Yes	2	9	9
41	R:R:F377	R:R:L51	7.31	Yes	Yes	2	9	9
42	R:R:A380	R:R:L51	4.73	No	Yes	0	8	9
43	R:R:F55	R:R:N56	4.83	Yes	Yes	0	8	9
44	R:R:F55	R:R:R118	7.48	Yes	Yes	0	8	9
45	R:R:F377	R:R:N56	9.67	Yes	Yes	2	9	9
46	R:R:I137	R:R:L57	4.28	Yes	No	0	7	5
47	R:R:F132	R:R:L58	7.31	No	No	0	7	8
48	R:R:N61	R:R:V106	4.43	Yes	No	4	9	8
49	R:R:N61	R:R:T110	10.24	Yes	No	0	9	8
50	R:R:L141	R:R:N61	8.24	No	Yes	0	8	9
51	R:R:N61	R:R:T144	7.31	Yes	No	0	9	7
52	R:R:N61	R:R:W145	6.78	Yes	No	4	9	9
53	R:R:L62	R:R:T110	7.37	No	No	0	9	8
54	R:R:L111	R:R:L62	4.15	No	No	0	8	9
55	R:R:L62	R:R:N366	6.87	No	Yes	0	9	9
56	R:R:D66	R:R:G363	5.03	No	No	0	9	9
57	R:R:D66	R:R:N366	4.04	No	Yes	0	9	9
58	R:R:L67	R:R:T71	4.42	No	No	0	7	5
59	R:R:L68	R:R:S103	7.51	No	No	0	7	6
60	R:R:L100	R:R:Y69	8.21	No	Yes	1	8	8
61	R:R:S103	R:R:Y69	6.36	No	Yes	0	6	8
62	R:R:N104	R:R:Y69	10.47	No	Yes	1	7	8
63	R:R:W360	R:R:Y69	6.75	Yes	Yes	1	8	8
64	L:L:?1	R:R:Y69	5.24	Yes	Yes	1	0	8
65	R:R:F96	R:R:L73	6.09	Yes	No	0	6	8
66	R:R:L73	R:R:L99	6.92	No	No	0	8	5
67	R:R:Q74	R:R:W360	18.62	No	Yes	0	8	8
68	R:R:F76	R:R:F92	9.65	No	No	0	6	4
69	R:R:S77	R:R:T167	4.8	No	Yes	0	7	4
70	R:R:D79	R:R:T80	4.34	No	No	0	6	6
71	R:R:T80	R:R:W86	8.49	No	Yes	0	6	8
72	R:R:C166	R:R:Y81	5.38	No	Yes	0	3	5
73	R:R:M353	R:R:Y81	8.38	No	Yes	0	5	5
74	R:R:N357	R:R:Y81	4.65	No	Yes	0	8	5
75	R:R:H83	R:R:R87	5.64	No	No	0	5	4
76	R:R:T88	R:R:W86	10.92	No	Yes	0	6	8
77	R:R:F96	R:R:W86	12.03	Yes	Yes	1	6	8
78	R:R:L161	R:R:W86	6.83	No	Yes	0	4	8
79	R:R:C168	R:R:W86	14.37	No	Yes	1	9	8
80	R:R:F92	R:R:T88	10.38	No	No	0	4	6
81	R:R:C168	R:R:C93	7.28	No	No	0	9	9
82	R:R:R94	R:R:W156	12	No	Yes	0	6	6
83	R:R:V95	R:R:W156	4.9	No	Yes	0	5	6
84	R:R:F96	R:R:L100	6.09	Yes	No	1	6	8
85	R:R:C168	R:R:F96	5.59	No	Yes	1	9	6
86	R:R:G97	R:R:Y159	10.14	No	No	0	6	5
87	R:R:L98	R:R:W156	4.56	No	Yes	0	7	6
88	R:R:L98	R:R:Y159	4.69	No	No	0	7	5
89	L:L:?1	R:R:L100	14.45	Yes	No	1	0	8
90	R:R:F101	R:R:F152	16.08	Yes	No	0	7	8
91	R:R:F101	R:R:S169	5.28	Yes	Yes	1	7	4
92	R:R:F101	R:R:F170	5.36	Yes	Yes	0	7	6
93	L:L:?1	R:R:F101	10.9	Yes	Yes	1	0	7
94	R:R:N104	R:R:Y332	8.14	No	Yes	0	7	8
95	L:L:?1	R:R:N104	15.35	Yes	No	1	0	7
96	R:R:S105	R:R:Y186	8.9	No	Yes	0	7	8
97	R:R:V106	R:R:W145	17.16	No	No	4	8	9
98	R:R:N362	R:R:S107	5.96	No	No	0	9	9
99	R:R:I108	R:R:Y186	4.84	No	Yes	0	8	8
100	R:R:I108	R:R:Y332	16.92	No	Yes	0	8	8
101	R:R:L109	R:R:Y186	4.69	No	Yes	0	6	8
102	R:R:C112	R:R:S193	6.89	No	No	0	6	7
103	R:R:I114	R:R:R118	5.01	No	Yes	3	9	9
104	R:R:I114	R:R:Y370	7.25	No	Yes	3	9	9
105	R:R:A115	R:R:F197	4.16	No	Yes	0	8	7
106	R:R:L116	R:R:L120	5.54	No	No	0	6	5
107	R:R:F197	R:R:L116	8.53	Yes	No	0	7	6
108	R:R:R118	R:R:Y198	10.29	Yes	Yes	0	9	9
109	R:R:R118	R:R:Y370	8.23	Yes	Yes	3	9	9
110	R:R:A123	R:R:Y119	5.34	No	Yes	5	7	9
111	R:R:H124	R:R:Y119	7.62	Yes	Yes	5	5	9
112	R:R:F197	R:R:Y119	6.19	Yes	Yes	0	7	9
113	R:R:L200	R:R:Y119	8.21	No	Yes	0	6	9
114	R:R:L120	R:R:V131	4.47	No	No	0	5	5
115	R:R:A123	R:R:H124	4.39	No	Yes	5	7	5
116	R:R:H124	R:R:L127	6.43	Yes	No	0	5	5
117	R:R:L127	R:R:Q130	6.65	No	No	0	5	5
118	R:R:F128	R:R:P129	4.33	Yes	No	0	8	6
119	R:R:F128	R:R:F132	6.43	Yes	No	0	8	7
120	R:R:I137	R:R:L141	5.71	Yes	No	0	7	8
121	R:R:L182	R:R:S151	6.01	No	No	0	8	7
122	R:R:F152	R:R:L182	4.87	No	No	0	8	8
123	R:R:I158	R:R:L155	5.71	No	No	0	5	8
124	R:R:L155	R:R:T179	7.37	No	No	0	8	6
125	R:R:P157	R:R:W156	5.4	No	Yes	0	5	6
126	R:R:D171	R:R:I158	7	No	No	6	7	5
127	R:R:I158	R:R:R174	8.77	No	No	6	5	5
128	R:R:D171	R:R:I160	9.8	No	No	0	7	3
129	R:R:V164	R:R:V345	4.81	No	No	0	2	4
130	R:R:R349	R:R:V164	9.15	No	No	0	1	2
131	R:R:H352	R:R:V164	8.3	Yes	No	0	4	2
132	R:R:T167	R:R:V165	6.35	Yes	No	1	4	4
133	R:R:R172	R:R:V165	6.54	Yes	No	0	5	4
134	L:L:?1	R:R:V165	6.66	Yes	No	1	0	4
135	R:R:S169	R:R:T167	4.8	Yes	Yes	1	4	4
136	L:L:?1	R:R:T167	10.99	Yes	Yes	1	0	4
137	R:R:R172	R:R:S169	5.27	Yes	Yes	0	5	4
138	L:L:?1	R:R:S169	6.72	Yes	Yes	1	0	4
139	R:R:F170	R:R:R172	17.1	Yes	Yes	0	6	5
140	R:R:F170	R:R:T179	12.97	Yes	No	0	6	6
141	R:R:D171	R:R:R174	17.87	No	No	6	7	5
142	R:R:N339	R:R:R172	9.64	No	Yes	0	7	5
143	R:R:R176	R:R:T180	6.47	No	No	0	4	6
144	R:R:P177	R:R:Y178	4.17	No	No	0	3	8
145	R:R:I340	R:R:M183	4.37	No	No	0	6	8
146	L:L:?1	R:R:Y186	6.99	Yes	Yes	0	0	8
147	R:R:F187	R:R:I333	7.54	No	Yes	0	8	7
148	R:R:F187	R:R:L336	7.31	No	No	0	8	7
149	R:R:I333	R:R:L191	7.14	Yes	No	0	7	6
150	R:R:V324	R:R:Y198	12.62	No	Yes	0	8	9
151	R:R:H202	R:R:T318	12.32	No	No	0	6	7
152	R:R:Q204	R:R:R207	10.51	No	No	0	6	5
153	R:R:V205	R:R:V317	6.41	No	No	0	8	8
154	R:R:K206	R:R:Q210	10.85	No	No	0	6	6
155	R:R:Q214	R:R:Y215	19.16	No	No	0	3	6
156	R:R:M320	R:R:M373	4.33	No	No	0	8	7
157	R:R:L369	R:R:V324	7.45	No	No	0	9	8
158	R:R:C327	R:R:I365	8.18	No	Yes	0	6	7
159	R:R:F328	R:R:Y332	7.22	No	Yes	0	9	8
160	R:R:L330	R:R:L361	4.15	No	No	0	5	5
161	R:R:L361	R:R:S331	4.5	No	No	0	5	8
162	R:R:N362	R:R:Y332	15.12	No	Yes	0	9	8
163	R:R:F335	R:R:N339	10.87	No	No	0	8	7
164	L:L:?1	R:R:F335	12.71	Yes	No	0	0	8
165	L:L:?1	R:R:L336	4.13	Yes	No	0	0	7
166	R:R:H352	R:R:L338	14.14	Yes	No	0	4	5
167	R:R:H352	R:R:N339	6.38	Yes	No	0	4	7
168	R:R:D342	R:R:Q346	7.83	No	No	0	4	2
169	R:R:A347	R:R:D342	4.63	No	No	0	5	4
170	R:R:D342	R:R:H352	5.04	No	Yes	0	4	4
171	R:R:Q346	R:R:R344	4.67	No	No	0	2	3
172	R:R:P348	R:R:V351	5.3	No	No	0	6	5
173	R:R:N357	R:R:W360	13.56	No	Yes	0	8	8
174	L:L:?1	R:R:T359	10.99	Yes	No	0	0	8
175	L:L:?1	R:R:W360	5.94	Yes	Yes	1	0	8
176	R:R:I365	R:R:L361	4.28	Yes	No	0	7	5
177	R:R:N362	R:R:N366	10.9	No	Yes	0	9	9
178	R:R:I365	R:R:N366	4.25	Yes	Yes	0	7	9
179	R:R:I365	R:R:L369	4.28	Yes	No	0	7	9
180	R:R:N366	R:R:Y370	5.81	Yes	Yes	0	9	9
181	R:R:L369	R:R:Y370	4.69	No	Yes	0	9	9
182	R:R:N374	R:R:Q376	5.28	No	No	0	9	7
183	R:R:F377	R:R:N374	9.67	Yes	No	0	9	9
184	R:R:A44	R:R:Y381	4	No	No	0	8	8
185	R:R:A115	R:R:Y198	4	No	Yes	0	8	9
186	R:R:F132	R:R:V131	3.93	No	No	0	7	5
187	R:R:F328	R:R:V194	3.93	No	No	0	9	8
188	R:R:C70	R:R:G34	3.92	No	No	0	7	8
189	R:R:R172	R:R:V162	3.92	Yes	No	0	5	3
190	R:R:C11	R:R:P163	3.77	No	No	0	5	3
191	R:R:F55	R:R:I59	3.77	Yes	No	0	8	8
192	R:R:F377	R:R:I59	3.77	Yes	No	0	9	8
193	R:R:F170	R:R:M183	3.73	Yes	No	0	6	8
194	R:R:G148	R:R:S105	3.71	No	No	0	8	7
195	R:R:G136	R:R:S133	3.71	No	No	0	7	7
196	R:R:F55	R:R:L121	3.65	Yes	No	0	8	8
197	R:R:F128	R:R:L121	3.65	Yes	No	0	8	8
198	R:R:G89	R:R:T88	3.64	No	No	0	7	6
199	R:R:G175	R:R:T179	3.64	No	No	0	7	6
200	R:R:L200	R:R:R203	3.64	No	No	0	6	5
201	R:R:L84	R:R:Y12	3.52	No	No	0	5	8
202	R:R:L155	R:R:Y159	3.52	No	No	0	8	5
203	L:L:?1	R:R:A356	3.52	Yes	No	0	0	6
204	R:R:C70	R:R:V30	3.42	No	Yes	0	7	6
205	R:R:A65	R:R:V106	3.39	No	No	0	8	8
206	R:R:I333	R:R:P334	3.39	Yes	No	0	7	9
207	R:R:L358	R:R:P334	3.28	No	No	0	9	9
208	R:R:V24	R:R:V78	3.21	No	No	0	6	7
209	R:R:C199	R:R:L200	3.17	No	No	0	2	6
210	R:R:C327	R:R:L326	3.17	No	No	0	6	6
211	R:R:P49	R:R:Q48	3.16	No	Yes	0	6	7
212	R:R:A60	R:R:L45	3.15	No	No	0	6	8
213	R:R:A355	R:R:L338	3.15	No	No	0	6	5
214	R:R:I365	R:R:V368	3.07	Yes	No	0	7	6
215	R:R:M320	R:R:V324	3.04	No	No	0	8	8
216	R:R:F55	R:R:G117	3.01	Yes	No	0	8	9
217	R:R:F128	R:R:G117	3.01	Yes	No	0	8	9
218	R:R:F325	R:R:G195	3.01	No	No	0	8	5
219	R:R:L42	R:R:T63	2.95	No	No	0	7	9
220	R:R:I122	R:R:I201	2.94	No	No	0	8	9
221	R:R:I47	R:R:L43	2.85	No	No	0	5	5
222	R:R:I340	R:R:L341	2.85	No	No	0	6	5
223	R:R:G27	R:R:W360	2.81	No	Yes	0	5	8
224	R:R:A134	R:R:R54	2.77	No	No	0	3	7
225	R:R:L113	R:R:L58	2.77	No	No	0	7	8
226	R:R:L72	R:R:L73	2.77	No	No	0	5	8
227	R:R:A343	R:R:R176	2.77	No	No	0	5	4
228	R:R:C321	R:R:Y198	2.69	No	Yes	0	8	9
229	R:R:F197	R:R:S193	2.64	Yes	No	0	7	7
230	R:R:F325	R:R:V194	2.62	No	No	0	8	8
231	R:R:D213	R:R:Q210	2.61	No	No	0	3	6
232	R:R:F314	R:R:T318	2.59	No	No	0	8	7
233	R:R:F322	R:R:T318	2.59	No	No	0	6	7
234	R:R:H83	R:R:L82	2.57	No	No	0	5	5
235	R:R:I137	R:R:R54	2.51	Yes	No	0	7	7
236	R:R:I201	R:R:Y119	2.42	No	Yes	0	9	9
237	R:R:I201	R:R:Y198	2.42	No	Yes	0	9	9
238	R:R:H83	R:R:H85	2.39	No	No	0	5	4
239	R:R:D79	R:R:R87	2.38	No	No	0	6	4
240	R:R:L40	R:R:Y381	2.34	No	No	0	8	8
241	R:R:C112	R:R:G190	1.96	No	No	0	6	8
242	R:R:A31	R:R:P75	1.87	No	No	0	6	9
243	R:R:A153	R:R:P154	1.87	No	No	0	5	7
244	R:R:A347	R:R:P348	1.87	No	No	0	5	6
245	R:R:G37	R:R:V36	1.84	No	No	0	9	5
246	R:R:A380	R:R:A44	1.79	No	No	0	8	8
247	R:R:G184	R:R:I340	1.76	No	No	0	5	6
248	R:R:G136	R:R:L139	1.71	No	No	0	7	4
249	R:R:C321	R:R:V317	1.71	No	No	0	8	8
250	R:R:A102	R:R:V149	1.7	No	No	0	6	5
251	R:R:S25	R:R:V24	1.62	No	No	0	4	6
252	R:R:A329	R:R:I333	1.62	No	Yes	0	6	7
253	R:R:A323	R:R:M320	1.61	No	No	0	7	8
254	R:R:V28	R:R:V78	1.6	No	No	0	4	7
255	R:R:V138	R:R:V142	1.6	No	No	0	3	5
256	R:R:T33	R:R:V32	1.59	No	No	0	4	5
257	R:R:C112	R:R:L189	1.59	No	No	0	6	5
258	R:R:P75	R:R:Q74	1.58	No	No	0	9	8
259	R:R:A140	R:R:L113	1.58	No	No	0	7	7
260	R:R:I196	R:R:S192	1.55	No	No	0	5	4
261	R:R:I137	R:R:V138	1.54	Yes	No	0	7	3
262	R:R:I173	R:R:V345	1.54	No	No	0	4	4
263	R:R:I185	R:R:V188	1.54	No	No	0	6	6
264	R:R:H124	R:R:P125	1.53	Yes	No	0	5	8
265	R:R:A123	R:R:Q204	1.52	No	No	0	7	6
266	R:R:I181	R:R:T180	1.52	No	No	0	5	6
267	R:R:L67	R:R:V39	1.49	No	No	0	7	5
268	R:R:L109	R:R:V147	1.49	No	No	0	6	4
269	R:R:N56	R:R:T53	1.46	Yes	No	0	9	7
270	R:R:G382	R:R:Y381	1.45	No	No	0	5	8
271	R:R:P177	R:R:R176	1.44	No	No	0	3	4
272	R:R:I185	R:R:L189	1.43	No	No	0	6	5
273	R:R:H85	R:R:S10	1.39	No	No	0	4	8
274	R:R:D213	R:R:K216	1.38	No	No	0	3	5
275	R:R:F314	R:R:V205	1.31	No	No	0	8	8
276	R:R:I47	R:R:R387	1.25	No	No	0	5	7
277	R:R:F187	R:R:L337	1.22	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y19	6.4375	4	0	5
2	R:R:V30	5.4575	4	0	6
3	R:R:N38	9.0725	4	0	9
4	R:R:Q48	7.655	4	0	7
5	R:R:L51	5.37	4	2	9
6	R:R:F55	4.548	5	0	8
7	R:R:N56	5.02	4	2	9
8	R:R:N61	7.4	5	4	9
9	R:R:Y69	7.406	5	1	8
10	R:R:Y81	6.27	4	0	5
11	R:R:W86	10.528	5	1	8
12	R:R:F96	7.45	4	1	6
13	R:R:F101	9.405	4	1	7
14	R:R:R118	7.7525	4	3	9
15	R:R:Y119	5.956	5	5	9
16	R:R:H124	4.9925	4	5	5
17	R:R:F128	4.355	4	0	8
18	R:R:I137	3.51	4	0	7
19	R:R:W156	6.715	4	0	6
20	R:R:T167	6.735	4	1	4
21	R:R:S169	5.5175	4	1	4
22	R:R:F170	9.79	4	0	6
23	R:R:R172	8.494	5	0	5
24	R:R:Y186	6.355	4	0	8
25	R:R:F197	5.38	4	0	7
26	R:R:Y198	6.404	5	0	9
27	R:R:Y332	11.85	4	0	8
28	R:R:I333	4.9225	4	0	7
29	R:R:H352	8.465	4	0	4
30	R:R:W360	9.35167	6	1	8
31	R:R:I365	4.812	5	0	7
32	R:R:N366	6.374	5	0	9
33	R:R:Y370	6.495	4	3	9
34	R:R:F377	7.546	5	2	9
35	L:L:?1	8.81461	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T80	R:R:W86	19.9713	8.49	No	Yes	0	6	8
2	R:R:D79	R:R:T80	18.3505	4.34	No	No	0	6	6
3	R:R:D79	R:R:R87	16.7218	2.38	No	No	0	6	4
4	R:R:H83	R:R:R87	15.085	5.64	No	No	0	5	4
5	R:R:C11	R:R:C166	11.5368	7.28	No	No	0	5	3
6	R:R:C166	R:R:Y81	13.1536	5.38	No	Yes	0	3	5
7	R:R:N357	R:R:Y81	25.7417	4.65	No	Yes	0	8	5
8	R:R:N357	R:R:W360	27.2908	13.56	No	Yes	0	8	8
9	R:R:W360	R:R:Y69	23.0696	6.75	Yes	Yes	1	8	8
10	R:R:L100	R:R:Y69	18.2669	8.21	No	Yes	1	8	8
11	R:R:F96	R:R:L100	41.7666	6.09	Yes	No	1	6	8
12	R:R:F96	R:R:W86	32.4917	12.03	Yes	Yes	1	6	8
13	L:L:?1	R:R:W360	32.0218	5.94	Yes	Yes	1	0	8
14	L:L:?1	R:R:L100	24.9652	14.45	Yes	No	1	0	8
15	R:R:H352	R:R:N339	16.3713	6.38	Yes	No	0	4	7
16	R:R:F335	R:R:N339	15.0412	10.87	No	No	0	8	7
17	L:L:?1	R:R:F335	15.8496	12.71	Yes	No	0	0	8
18	R:R:W26	R:R:W360	12.8908	8.43	No	Yes	0	5	8
19	R:R:Q74	R:R:W360	14.4518	18.62	No	Yes	0	8	8
20	R:R:N104	R:R:Y69	34.4311	10.47	No	Yes	1	7	8
21	R:R:N104	R:R:Y332	98.3274	8.14	No	Yes	0	7	8
22	R:R:N362	R:R:Y332	100	15.12	No	Yes	0	9	8
23	R:R:N362	R:R:N366	99.3788	10.9	No	Yes	0	9	9
24	R:R:D66	R:R:N366	18.5735	4.04	No	Yes	0	9	9
25	R:R:D66	R:R:N38	16.2001	13.46	No	Yes	0	9	9
26	L:L:?1	R:R:N104	64.1432	15.35	Yes	No	1	0	7
27	R:R:F55	R:R:N56	21.8589	4.83	Yes	Yes	0	8	9
28	R:R:F55	R:R:R118	45.6453	7.48	Yes	Yes	0	8	9
29	R:R:R118	R:R:Y370	70.7658	8.23	Yes	Yes	3	9	9
30	R:R:N366	R:R:Y370	75.7158	5.81	Yes	Yes	0	9	9
31	R:R:L51	R:R:N56	13.4443	4.12	Yes	Yes	2	9	9
32	R:R:N61	R:R:T110	14.9974	10.24	Yes	No	0	9	8
33	R:R:L62	R:R:T110	16.1961	7.37	No	No	0	9	8
34	R:R:L62	R:R:N366	18.5696	6.87	No	Yes	0	9	9
35	R:R:F128	R:R:F132	11.9231	6.43	Yes	No	0	8	7
36	L:L:?1	R:R:F101	20.1067	10.9	Yes	Yes	1	0	7
37	R:R:F101	R:R:F170	17.2076	5.36	Yes	Yes	0	7	6
38	R:R:F170	R:R:T179	14.2129	12.97	Yes	No	0	6	6
39	R:R:L155	R:R:T179	12.2775	7.37	No	No	0	8	6
40	R:R:A115	R:R:F197	10.2385	4.16	No	Yes	0	8	7
41	R:R:A115	R:R:Y198	11.2939	4	No	Yes	0	8	9
42	R:R:R118	R:R:Y198	33.79	10.29	Yes	Yes	0	9	9
43	R:R:I201	R:R:Y119	12.8111	2.42	No	Yes	0	9	9
44	R:R:I201	R:R:Y198	14.9775	2.42	No	Yes	0	9	9
45	R:R:I365	R:R:N366	12.4049	4.25	Yes	Yes	0	7	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:W26	R:R:W360	8.43	0	No	Yes	5	8	2	1
R:R:L100	R:R:Y69	8.21	1	No	Yes	8	8	1	1
R:R:S103	R:R:Y69	6.36	0	No	Yes	6	8	2	1
R:R:N104	R:R:Y69	10.47	1	No	Yes	7	8	1	1
R:R:W360	R:R:Y69	6.75	1	Yes	Yes	8	8	1	1
L:L:?1	R:R:Y69	5.24	1	Yes	Yes	0	8	0	1
R:R:Q74	R:R:W360	18.62	0	No	Yes	8	8	2	1
R:R:S77	R:R:T167	4.8	0	No	Yes	7	4	2	1
R:R:F96	R:R:L100	6.09	1	Yes	No	6	8	2	1
L:L:?1	R:R:L100	14.45	1	Yes	No	0	8	0	1
R:R:F101	R:R:F152	16.08	1	Yes	No	7	8	1	2
R:R:F101	R:R:S169	5.28	1	Yes	Yes	7	4	1	1
R:R:F101	R:R:F170	5.36	1	Yes	Yes	7	6	1	2
L:L:?1	R:R:F101	10.9	1	Yes	Yes	0	7	0	1
R:R:N104	R:R:Y332	8.14	1	No	Yes	7	8	1	2
L:L:?1	R:R:N104	15.35	1	Yes	No	0	7	0	1
R:R:S105	R:R:Y186	8.9	0	No	Yes	7	8	2	1
R:R:I108	R:R:Y186	4.84	0	No	Yes	8	8	2	1
R:R:I108	R:R:Y332	16.92	0	No	Yes	8	8	2	2
R:R:L109	R:R:Y186	4.69	0	No	Yes	6	8	2	1
R:R:T167	R:R:V165	6.35	1	Yes	No	4	4	1	1
R:R:R172	R:R:V165	6.54	0	Yes	No	5	4	2	1
L:L:?1	R:R:V165	6.66	1	Yes	No	0	4	0	1
R:R:S169	R:R:T167	4.8	1	Yes	Yes	4	4	1	1
L:L:?1	R:R:T167	10.99	1	Yes	Yes	0	4	0	1
R:R:R172	R:R:S169	5.27	0	Yes	Yes	5	4	2	1
L:L:?1	R:R:S169	6.72	1	Yes	Yes	0	4	0	1
R:R:F170	R:R:R172	17.1	0	Yes	Yes	6	5	2	2
R:R:N339	R:R:R172	9.64	0	No	Yes	7	5	2	2
L:L:?1	R:R:Y186	6.99	1	Yes	Yes	0	8	0	1
R:R:F187	R:R:L336	7.31	0	No	No	8	7	2	1
R:R:F335	R:R:N339	10.87	0	No	No	8	7	1	2
L:L:?1	R:R:F335	12.71	1	Yes	No	0	8	0	1
L:L:?1	R:R:L336	4.13	1	Yes	No	0	7	0	1
R:R:N357	R:R:W360	13.56	0	No	Yes	8	8	2	1
L:L:?1	R:R:T359	10.99	1	Yes	No	0	8	0	1
L:L:?1	R:R:W360	5.94	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:A356	3.52	1	Yes	No	0	6	0	1
R:R:G27	R:R:W360	2.81	0	No	Yes	5	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8G05_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.03
Number of Linked Nodes	263
Number of Links	277
Number of Hubs	35
Number of Links mediated by Hubs	136
Number of Communities	6
Number of Nodes involved in Communities	27
Number of Links involved in Communities	33

Path Summary
Number Of Nodes in MetaPath	46
Number Of Links MetaPath	45
Number of Shortest Paths	43164
Length Of Smallest Path	3
Average Path Length	12.2946
Length of Longest Path	26
Minimum Path Strength	1.485
Average Path Strength	7.73692
Maximum Path Strength	16.09
Minimum Path Correlation	0.7
Average Path Correlation	0.93832
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	6.66667
Average % Of Corr. Nodes	61.0572
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.4723
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • neuropeptide signaling pathway • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • urotensin II receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • receptor complex • tertiary granule membrane • intracellular vesicle • tertiary granule • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule membrane • specific granule
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	YI9
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	YI9
Name	6-(octylamino)pyrimidine-2,4(3H,5H)-dione
Synonyms
Identifier
Formula	C12 H21 N3 O2
Molecular Weight	239.314
SMILES
PubChem	125356668
Formal Charge	0
Total Atoms	38
Total Chiral Atoms	0
Total Bonds	38
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NQS5
Sequence	>8G05_nogp_Chain_R D A N F S C Y H E S V L G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q P K L R T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H L H W R T G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H P K L F P Q V F S A K G I V L A L V S T W V V G V A S F A P L W P I Y I L V P V V C T C S F D R I R G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K L F G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A R V Q A P R V V H M L A A N L T W L N G C I N P V L Y A A M N R Q F R Q A Y G S I L K R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J18	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-	Gi1/β1/γ2	2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J18 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-		2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A	A	Orphan	Orphan	GPR84	Homo sapiens	-	-	Gi1/β1/γ2	3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	-	-		3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8G05	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-	Gi1/β1/γ2	3	2023-11-01	doi.org/10.1038/s41467-023-41201-0
	8G05 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-		3	2023-11-01	doi.org/10.1038/s41467-023-41201-0

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.