psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F9	R:R:N8	7.25	Yes	No	0	7	5
2	R:R:F9	R:R:I160	6.28	Yes	No	0	7	3
3	R:R:F9	R:R:L161	6.09	Yes	No	0	7	4
4	R:R:L84	R:R:S10	7.51	No	No	0	5	8
5	R:R:C11	R:R:C166	7.28	No	No	0	5	3
6	R:R:E14	R:R:Y12	11.22	No	No	0	6	8
7	R:R:H13	R:R:S15	6.97	No	No	0	6	8
8	R:R:E14	R:R:L17	5.3	No	No	0	6	4
9	R:R:V16	R:R:V350	4.81	Yes	No	0	6	3
10	R:R:M353	R:R:V16	4.56	No	Yes	0	5	6
11	R:R:V22	R:R:Y19	5.05	No	Yes	0	5	5
12	R:R:M353	R:R:Y19	8.38	No	Yes	0	5	5
13	R:R:L354	R:R:Y19	8.21	No	Yes	0	4	5
14	R:R:N357	R:R:Y19	6.98	Yes	Yes	0	8	5
15	R:R:A23	R:R:Y81	4	No	Yes	0	7	5
16	R:R:L82	R:R:V24	7.45	No	No	0	5	6
17	R:R:V29	R:R:W26	3.68	No	Yes	0	4	5
18	R:R:V30	R:R:W26	9.81	No	Yes	2	6	5
19	R:R:N357	R:R:W26	5.65	Yes	Yes	2	8	5
20	R:R:W26	R:R:W360	5.62	Yes	Yes	2	5	8
21	R:R:L361	R:R:W26	3.42	No	Yes	0	5	5
22	R:R:C364	R:R:W26	3.92	No	Yes	2	6	5
23	R:R:G27	R:R:W360	4.22	No	Yes	0	5	8
24	R:R:C364	R:R:V30	3.42	No	No	2	6	6
25	R:R:C364	R:R:T33	5.07	No	No	0	6	4
26	R:R:G37	R:R:V36	3.68	No	No	0	9	5
27	R:R:G37	R:R:P367	4.06	No	No	0	9	9
28	R:R:N38	R:R:T63	7.31	No	No	0	9	9
29	R:R:D66	R:R:N38	13.46	No	No	0	9	9
30	R:R:L67	R:R:N38	5.49	No	No	0	7	9
31	R:R:L40	R:R:Y381	3.52	No	No	0	8	8
32	R:R:T41	R:R:T63	9.42	Yes	No	0	9	9
33	R:R:A371	R:R:T41	5.03	No	Yes	4	8	9
34	R:R:F377	R:R:T41	3.89	Yes	Yes	4	9	9
35	R:R:L42	R:R:T63	5.9	No	No	0	7	9
36	R:R:L42	R:R:L64	6.92	No	No	0	7	6
37	R:R:L45	R:R:R52	3.64	No	No	0	8	7
38	R:R:A380	R:R:Q48	6.06	No	Yes	0	8	7
39	R:R:F377	R:R:L51	7.31	Yes	No	0	9	9
40	R:R:N56	R:R:T53	4.39	No	No	0	9	7
41	R:R:F55	R:R:I59	3.77	Yes	No	0	8	8
42	R:R:F55	R:R:R118	4.28	Yes	Yes	1	8	9
43	R:R:F128	R:R:F55	4.29	Yes	Yes	1	8	8
44	R:R:F377	R:R:N56	6.04	Yes	No	0	9	9
45	R:R:I137	R:R:L57	7.14	No	No	0	7	5
46	R:R:L113	R:R:L58	4.15	No	Yes	0	7	8
47	R:R:I114	R:R:L58	4.28	No	Yes	0	9	8
48	R:R:F132	R:R:L58	6.09	No	Yes	0	7	8
49	R:R:N61	R:R:T110	10.24	No	No	0	9	8
50	R:R:L141	R:R:N61	12.36	No	No	0	8	9
51	R:R:N61	R:R:W145	5.65	No	No	0	9	9
52	R:R:L62	R:R:S107	4.5	Yes	No	0	9	9
53	R:R:L62	R:R:T110	7.37	Yes	No	0	9	8
54	R:R:L111	R:R:L62	5.54	No	Yes	1	8	9
55	R:R:L62	R:R:N366	6.87	Yes	No	0	9	9
56	R:R:L62	R:R:Y370	3.52	Yes	Yes	1	9	9
57	R:R:A65	R:R:V106	3.39	No	No	0	8	8
58	R:R:C70	R:R:D66	4.67	No	No	0	7	9
59	R:R:D66	R:R:G363	5.03	No	No	0	9	9
60	R:R:L67	R:R:T71	4.42	No	No	0	7	5
61	R:R:Q74	R:R:Y69	12.4	Yes	No	2	8	8
62	R:R:S103	R:R:Y69	3.82	No	No	0	6	8
63	R:R:W360	R:R:Y69	10.61	Yes	No	2	8	8
64	R:R:F96	R:R:L73	10.96	Yes	No	0	6	8
65	R:R:L73	R:R:L99	4.15	No	No	0	8	5
66	R:R:Q74	R:R:W360	21.9	Yes	Yes	2	8	8
67	R:R:F76	R:R:T88	3.89	No	No	3	6	6
68	R:R:F76	R:R:F92	5.36	No	No	3	6	4
69	R:R:F76	R:R:F96	7.5	No	Yes	0	6	6
70	R:R:S77	R:R:T167	6.4	No	No	0	7	4
71	R:R:S77	R:R:W360	3.71	No	Yes	0	7	8
72	R:R:T80	R:R:W86	9.7	No	Yes	0	6	8
73	R:R:C166	R:R:Y81	5.38	No	Yes	0	3	5
74	R:R:M353	R:R:Y81	9.58	No	Yes	0	5	5
75	R:R:N357	R:R:Y81	3.49	Yes	Yes	0	8	5
76	R:R:H85	R:R:R87	5.64	No	No	0	4	4
77	R:R:T88	R:R:W86	13.34	No	Yes	3	6	8
78	R:R:C93	R:R:W86	5.22	No	Yes	3	9	8
79	R:R:C168	R:R:W86	5.22	No	Yes	3	9	8
80	R:R:F92	R:R:T88	10.38	No	No	3	4	6
81	R:R:C168	R:R:C93	7.28	No	No	3	9	9
82	R:R:R94	R:R:W156	14.99	No	Yes	5	6	6
83	R:R:P157	R:R:R94	4.32	No	No	5	5	6
84	R:R:V95	R:R:W156	3.68	No	Yes	0	5	6
85	R:R:F96	R:R:G97	4.52	Yes	No	0	6	6
86	R:R:F96	R:R:T167	3.89	Yes	No	0	6	4
87	R:R:G97	R:R:Y159	5.79	No	No	0	6	5
88	R:R:L98	R:R:W156	17.08	No	Yes	0	7	6
89	R:R:L98	R:R:Y159	19.93	No	No	0	7	5
90	R:R:F101	R:R:L100	3.65	Yes	No	0	7	8
91	R:R:F101	R:R:F152	15	Yes	Yes	0	7	8
92	R:R:F101	R:R:F170	8.57	Yes	No	0	7	6
93	R:R:N104	R:R:Y332	6.98	No	Yes	0	7	8
94	R:R:F152	R:R:S105	7.93	Yes	No	0	8	7
95	R:R:S105	R:R:Y186	13.99	No	No	0	7	8
96	R:R:V106	R:R:W145	13.48	No	No	0	8	9
97	R:R:N362	R:R:S107	5.96	Yes	No	0	9	9
98	R:R:I108	R:R:Y332	13.3	No	Yes	0	8	8
99	R:R:L109	R:R:Y186	4.69	No	No	0	6	8
100	R:R:L111	R:R:Y370	3.52	No	Yes	1	8	9
101	R:R:C112	R:R:S193	6.89	No	No	0	6	7
102	R:R:I114	R:R:R118	6.26	No	Yes	1	9	9
103	R:R:I114	R:R:Y370	4.84	No	Yes	1	9	9
104	R:R:A115	R:R:F197	4.16	No	Yes	0	8	7
105	R:R:L116	R:R:L120	4.15	No	No	0	6	5
106	R:R:F197	R:R:L116	9.74	Yes	No	0	7	6
107	R:R:R118	R:R:Y198	8.23	Yes	Yes	0	9	9
108	R:R:R118	R:R:Y370	6.17	Yes	Yes	1	9	9
109	R:R:A123	R:R:Y119	5.34	No	Yes	7	7	9
110	R:R:H124	R:R:Y119	8.71	Yes	Yes	7	5	9
111	R:R:F197	R:R:Y119	8.25	Yes	Yes	0	7	9
112	R:R:L200	R:R:Y119	10.55	No	Yes	0	6	9
113	R:R:I201	R:R:Y119	3.63	No	Yes	0	9	9
114	R:R:L120	R:R:L127	5.54	No	No	0	5	5
115	R:R:L120	R:R:V131	4.47	No	No	0	5	5
116	R:R:F128	R:R:L121	12.18	Yes	No	0	8	8
117	R:R:I122	R:R:I201	8.83	No	No	0	8	9
118	R:R:A123	R:R:H124	5.85	No	Yes	7	7	5
119	R:R:A123	R:R:Q204	4.55	No	No	0	7	6
120	R:R:H124	R:R:L127	5.14	Yes	No	0	5	5
121	R:R:F128	R:R:P129	4.33	Yes	No	0	8	6
122	R:R:F128	R:R:F132	12.86	Yes	No	0	8	7
123	R:R:F132	R:R:V131	7.87	No	No	0	7	5
124	R:R:F152	R:R:S151	7.93	Yes	No	0	8	7
125	R:R:S151	R:R:Y186	7.63	No	No	0	7	8
126	R:R:F152	R:R:Y159	4.13	Yes	No	0	8	5
127	R:R:I158	R:R:L155	5.71	No	No	0	5	8
128	R:R:L155	R:R:T179	7.37	No	No	0	8	6
129	R:R:P157	R:R:W156	4.05	No	Yes	5	5	6
130	R:R:D171	R:R:I160	5.6	No	No	0	7	3
131	R:R:C168	R:R:L161	6.35	No	No	0	9	4
132	R:R:P163	R:R:V162	3.53	No	No	0	3	3
133	R:R:R172	R:R:V162	5.23	Yes	No	0	5	3
134	R:R:R172	R:R:V165	3.92	Yes	No	0	5	4
135	R:R:F170	R:R:R172	19.24	No	Yes	0	6	5
136	R:R:F170	R:R:T179	9.08	No	No	0	6	6
137	R:R:D171	R:R:I173	7	No	No	0	7	4
138	R:R:D171	R:R:R174	13.1	No	No	0	7	5
139	R:R:F335	R:R:R172	4.28	Yes	Yes	8	8	5
140	R:R:N339	R:R:R172	10.85	Yes	Yes	8	7	5
141	R:R:I173	R:R:R176	3.76	No	Yes	0	4	4
142	R:R:R176	R:R:R344	21.32	Yes	No	9	4	3
143	R:R:P177	R:R:Y178	9.74	No	No	0	3	8
144	R:R:I340	R:R:T180	4.56	No	No	0	6	6
145	R:R:M183	R:R:N339	4.21	No	Yes	0	8	7
146	R:R:G184	R:R:I340	3.53	No	No	0	5	6
147	R:R:F187	R:R:V188	3.93	Yes	No	0	8	6
148	R:R:F187	R:R:I333	5.02	Yes	Yes	0	8	7
149	R:R:F187	R:R:L336	4.87	Yes	No	0	8	7
150	R:R:F328	R:R:G190	4.52	No	No	0	9	8
151	R:R:F197	R:R:S193	6.61	Yes	No	0	7	7
152	R:R:C321	R:R:Y198	9.41	No	Yes	0	8	9
153	R:R:V324	R:R:Y198	15.14	No	Yes	0	8	9
154	R:R:C199	R:R:R203	6.96	No	No	0	2	5
155	R:R:L200	R:R:R203	6.07	No	No	0	6	5
156	R:R:H202	R:R:T318	13.69	No	No	0	6	7
157	R:R:Q214	R:R:Y215	13.53	No	No	0	3	6
158	R:R:M320	R:R:M373	5.78	No	No	0	8	7
159	R:R:V324	R:R:Y370	6.31	No	Yes	0	8	9
160	R:R:C327	R:R:I365	6.55	No	No	0	6	7
161	R:R:C327	R:R:L369	4.76	No	Yes	0	6	9
162	R:R:S331	R:R:Y332	6.36	No	Yes	6	8	8
163	R:R:N362	R:R:S331	4.47	Yes	No	6	9	8
164	R:R:T359	R:R:Y332	3.75	No	Yes	0	8	8
165	R:R:N362	R:R:Y332	13.96	Yes	Yes	6	9	8
166	R:R:I333	R:R:P334	3.39	Yes	No	0	7	9
167	R:R:F335	R:R:N339	13.29	Yes	Yes	8	8	7
168	R:R:F335	R:R:T359	3.89	Yes	No	0	8	8
169	R:R:H352	R:R:L338	15.43	Yes	No	0	4	5
170	R:R:H352	R:R:N339	7.65	Yes	Yes	0	4	7
171	R:R:D342	R:R:H352	5.04	No	Yes	0	4	4
172	R:R:A347	R:R:H352	5.85	No	Yes	0	5	4
173	R:R:P348	R:R:R349	8.65	No	No	0	6	1
174	R:R:N357	R:R:W360	15.82	Yes	Yes	2	8	8
175	R:R:I365	R:R:L361	8.56	No	No	0	7	5
176	R:R:G363	R:R:N362	3.39	No	Yes	0	9	9
177	R:R:N362	R:R:N366	13.62	Yes	No	0	9	9
178	R:R:A372	R:R:V368	3.39	No	No	0	5	6
179	R:R:L369	R:R:Y370	3.52	Yes	Yes	0	9	9
180	R:R:A371	R:R:F377	4.16	No	Yes	4	8	9
181	R:R:N374	R:R:Q376	5.28	No	No	0	9	7
182	R:R:F377	R:R:N374	9.67	Yes	No	0	9	9
183	R:R:L385	R:R:Y381	7.03	No	No	0	7	8
184	R:R:G382	R:R:L385	3.42	No	No	0	5	7
185	R:R:R387	R:R:R390	5.33	No	No	0	7	5
186	R:R:G388	R:R:P389	4.06	No	No	0	4	3
187	R:R:F392	R:R:G388	6.02	No	No	0	8	4
188	R:R:C70	R:R:T35	3.38	No	No	0	7	7
189	R:R:L358	R:R:P334	3.28	No	No	0	9	9
190	R:R:V28	R:R:V78	3.21	No	No	0	4	7
191	R:R:V162	R:R:V164	3.21	No	No	0	3	2
192	R:R:V164	R:R:V165	3.21	No	No	0	2	4
193	R:R:P75	R:R:Q74	3.16	No	Yes	0	9	8
194	R:R:P129	R:R:Q130	3.16	No	No	0	6	5
195	R:R:A140	R:R:L113	3.15	No	No	0	7	7
196	R:R:I196	R:R:S192	3.1	No	No	0	5	4
197	R:R:F55	R:R:G117	3.01	Yes	No	1	8	9
198	R:R:F128	R:R:G117	3.01	Yes	No	1	8	9
199	R:R:F325	R:R:G195	3.01	No	No	0	8	5
200	R:R:L68	R:R:S103	3	No	No	0	7	6
201	R:R:L182	R:R:S151	3	No	No	0	8	7
202	R:R:L40	R:R:V36	2.98	No	No	0	8	5
203	R:R:L67	R:R:V39	2.98	No	No	0	7	5
204	R:R:L109	R:R:V147	2.98	No	No	0	6	4
205	R:R:L72	R:R:T71	2.95	No	No	0	5	5
206	R:R:L109	R:R:T144	2.95	No	No	0	6	7
207	R:R:L113	R:R:T144	2.95	No	No	0	7	7
208	R:R:P177	R:R:R176	2.88	No	Yes	0	3	4
209	R:R:I137	R:R:L58	2.85	No	Yes	0	7	8
210	R:R:I185	R:R:L189	2.85	No	No	0	6	5
211	R:R:I333	R:R:L191	2.85	Yes	No	0	7	6
212	R:R:I196	R:R:L200	2.85	No	No	0	5	6
213	R:R:I333	R:R:L337	2.85	Yes	No	0	7	6
214	R:R:L336	R:R:M183	2.83	No	No	0	7	8
215	R:R:L369	R:R:M373	2.83	Yes	No	0	9	7
216	R:R:H13	R:R:V16	2.77	No	Yes	0	6	6
217	R:R:A44	R:R:F377	2.77	No	Yes	0	8	9
218	R:R:A356	R:R:F335	2.77	No	Yes	0	6	8
219	R:R:L337	R:R:L341	2.77	No	No	0	6	5
220	R:R:I47	R:R:Q48	2.74	No	Yes	0	5	7
221	R:R:L51	R:R:Q48	2.66	No	Yes	0	9	7
222	R:R:F101	R:R:S169	2.64	Yes	No	0	7	4
223	R:R:R20	R:R:V16	2.62	No	Yes	0	7	6
224	R:R:R172	R:R:V345	2.62	Yes	No	0	5	4
225	R:R:V194	R:R:Y198	2.52	No	Yes	0	8	9
226	R:R:F187	R:R:I340	2.51	Yes	No	0	8	6
227	R:R:K316	R:R:R319	2.48	No	No	0	8	6
228	R:R:D79	R:R:W86	2.23	No	Yes	0	6	8
229	R:R:F328	R:R:Y332	2.06	No	Yes	0	9	8
230	R:R:G175	R:R:P177	2.03	No	No	0	7	3
231	R:R:C70	R:R:G34	1.96	No	No	0	7	8
232	R:R:A153	R:R:P154	1.87	No	No	0	5	7
233	R:R:A347	R:R:P348	1.87	No	No	0	5	6
234	R:R:G148	R:R:S105	1.86	No	No	0	8	7
235	R:R:G388	R:R:S391	1.86	No	No	0	4	7
236	R:R:G27	R:R:V78	1.84	No	No	0	5	7
237	R:R:P367	R:R:T41	1.75	No	Yes	0	9	9
238	R:R:G136	R:R:K135	1.74	No	No	0	7	5
239	R:R:G382	R:R:K386	1.74	No	No	0	5	4
240	R:R:G18	R:R:L17	1.71	No	No	0	1	4
241	R:R:A134	R:R:S133	1.71	No	No	0	3	7
242	R:R:G136	R:R:L139	1.71	No	No	0	7	4
243	R:R:A140	R:R:S143	1.71	No	No	0	7	3
244	R:R:G190	R:R:L189	1.71	No	No	0	8	5
245	R:R:C321	R:R:V317	1.71	No	No	0	8	8
246	R:R:A329	R:R:I333	1.62	No	Yes	0	6	7
247	R:R:V24	R:R:V78	1.6	No	No	0	6	7
248	R:R:V28	R:R:V32	1.6	No	No	0	4	5
249	R:R:V205	R:R:V317	1.6	No	No	0	8	8
250	R:R:C327	R:R:L326	1.59	No	No	0	6	6
251	R:R:A60	R:R:L45	1.58	No	No	0	6	8
252	R:R:P49	R:R:Q48	1.58	No	Yes	0	6	7
253	R:R:A323	R:R:L369	1.58	No	Yes	0	7	9
254	R:R:A355	R:R:L338	1.58	No	No	0	6	5
255	R:R:P348	R:R:Q346	1.58	No	No	0	6	2
256	R:R:H124	R:R:P125	1.53	Yes	No	0	5	8
257	R:R:A31	R:R:Q74	1.52	No	Yes	0	6	8
258	R:R:I181	R:R:T180	1.52	No	No	0	5	6
259	R:R:M373	R:R:V368	1.52	No	No	0	7	6
260	R:R:L139	R:R:V138	1.49	No	No	0	4	3
261	R:R:L338	R:R:V351	1.49	No	No	0	5	5
262	R:R:I384	R:R:I47	1.47	No	No	0	7	5
263	R:R:Q48	R:R:S383	1.44	Yes	No	0	7	6
264	R:R:I47	R:R:L43	1.43	No	No	0	5	5
265	R:R:K50	R:R:L51	1.41	No	No	0	6	9
266	R:R:A90	R:R:F9	1.39	No	Yes	0	4	7
267	R:R:A329	R:R:F325	1.39	No	No	0	6	8
268	R:R:A343	R:R:R176	1.38	No	Yes	9	5	4
269	R:R:L330	R:R:L358	1.38	No	No	0	5	9
270	R:R:L330	R:R:L361	1.38	No	No	0	5	5
271	R:R:A343	R:R:R344	1.38	No	No	9	5	3
272	R:R:K206	R:R:Q210	1.36	No	No	0	6	6
273	R:R:D213	R:R:L212	1.36	No	No	0	3	4
274	R:R:R387	R:R:S383	1.32	No	No	0	7	6
275	R:R:R387	R:R:S391	1.32	No	No	0	7	7
276	R:R:E14	R:R:H13	1.23	No	No	0	6	6
277	R:R:F322	R:R:L326	1.22	No	No	0	6	6
278	R:R:Q48	R:R:R394	1.17	Yes	No	0	7	8
279	R:R:F392	R:R:H393	1.13	No	No	0	8	5
280	R:R:R20	R:R:Y21	1.03	No	No	0	7	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F9	5.2525	4	0	7
2	R:R:V16	3.69	4	0	6
3	R:R:Y19	7.155	4	0	5
4	R:R:W26	5.35	6	2	5
5	R:R:T41	5.0225	4	4	9
6	R:R:Q48	2.60833	6	0	7
7	R:R:F55	3.8375	4	1	8
8	R:R:L58	4.3425	4	0	8
9	R:R:L62	5.56	5	1	9
10	R:R:Q74	9.745	4	2	8
11	R:R:Y81	5.6125	4	0	5
12	R:R:W86	7.142	5	3	8
13	R:R:F96	6.7175	4	0	6
14	R:R:F101	7.465	4	0	7
15	R:R:R118	6.235	4	1	9
16	R:R:Y119	7.296	5	7	9
17	R:R:H124	5.3075	4	7	5
18	R:R:F128	7.334	5	1	8
19	R:R:F152	8.7475	4	0	8
20	R:R:W156	9.95	4	5	6
21	R:R:R172	7.69	6	8	5
22	R:R:R176	7.335	4	9	4
23	R:R:F187	4.0825	4	0	8
24	R:R:F197	7.19	4	0	7
25	R:R:Y198	8.825	4	0	9
26	R:R:Y332	7.735	6	6	8
27	R:R:I333	3.146	5	0	7
28	R:R:F335	6.0575	4	8	8
29	R:R:N339	9	4	8	7
30	R:R:H352	8.4925	4	0	4
31	R:R:N357	7.985	4	2	8
32	R:R:W360	10.3133	6	2	8
33	R:R:N362	8.28	5	6	9
34	R:R:L369	3.1725	4	0	9
35	R:R:Y370	4.64667	6	1	9
36	R:R:F377	5.64	6	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N357	R:R:Y81	24.7867	3.49	Yes	Yes	0	8	5
2	R:R:N357	R:R:W360	12.2354	15.82	Yes	Yes	2	8	8
3	R:R:S77	R:R:W360	27.5019	3.71	No	Yes	0	7	8
4	R:R:S77	R:R:T167	26.6707	6.4	No	No	0	7	4
5	R:R:F96	R:R:T167	26.4158	3.89	Yes	No	0	6	4
6	R:R:F76	R:R:F96	36.6896	7.5	No	Yes	0	6	6
7	R:R:F76	R:R:T88	33.4645	3.89	No	No	3	6	6
8	R:R:T88	R:R:W86	32.0016	13.34	No	Yes	3	6	8
9	R:R:C168	R:R:W86	25.5126	5.22	No	Yes	3	9	8
10	R:R:C168	R:R:L161	23.9665	6.35	No	No	0	9	4
11	R:R:F9	R:R:L161	22.3263	6.09	Yes	No	0	7	4
12	R:R:E14	R:R:H13	13.6041	1.23	No	No	0	6	6
13	R:R:H13	R:R:V16	20.3425	2.77	No	Yes	0	6	6
14	R:R:M353	R:R:V16	33.6861	4.56	No	Yes	0	5	6
15	R:R:M353	R:R:Y19	18.5304	8.38	No	Yes	0	5	5
16	R:R:N357	R:R:Y19	23.3016	6.98	Yes	Yes	0	8	5
17	R:R:M353	R:R:Y81	18.475	9.58	No	Yes	0	5	5
18	R:R:G27	R:R:W360	11.0994	4.22	No	Yes	0	5	8
19	R:R:W26	R:R:W360	28.1835	5.62	Yes	Yes	2	5	8
20	R:R:L361	R:R:W26	68.9405	3.42	No	Yes	0	5	5
21	R:R:F96	R:R:G97	38.9172	4.52	Yes	No	0	6	6
22	R:R:G97	R:R:Y159	39.7373	5.79	No	No	0	6	5
23	R:R:F152	R:R:Y159	45.384	4.13	Yes	No	0	8	5
24	R:R:F101	R:R:F152	35.6533	15	Yes	Yes	0	7	8
25	R:R:F101	R:R:F170	34.1738	8.57	Yes	No	0	7	6
26	R:R:F170	R:R:R172	33.8468	19.24	No	Yes	0	6	5
27	R:R:F335	R:R:R172	26.8813	4.28	Yes	Yes	8	8	5
28	R:R:F335	R:R:T359	46.0933	3.89	Yes	No	0	8	8
29	R:R:T359	R:R:Y332	47.2071	3.75	No	Yes	0	8	8
30	R:R:N362	R:R:Y332	55.1202	13.96	Yes	Yes	6	9	8
31	R:R:G363	R:R:N362	90.2084	3.39	No	Yes	0	9	9
32	R:R:D66	R:R:G363	88.485	5.03	No	No	0	9	9
33	R:R:D66	R:R:N38	81.4807	13.46	No	No	0	9	9
34	R:R:N38	R:R:T63	72.4759	7.31	No	No	0	9	9
35	R:R:T41	R:R:T63	66.94	9.42	Yes	No	0	9	9
36	R:R:P367	R:R:T41	17.3113	1.75	No	Yes	0	9	9
37	R:R:G37	R:R:P367	15.1668	4.06	No	No	0	9	9
38	R:R:G37	R:R:V36	13.0112	3.68	No	No	0	9	5
39	R:R:L40	R:R:V36	10.8445	2.98	No	No	0	8	5
40	R:R:F377	R:R:T41	47.7557	3.89	Yes	Yes	4	9	9
41	R:R:L51	R:R:Q48	31.7466	2.66	No	Yes	0	9	7
42	R:R:F377	R:R:L51	35.8473	7.31	Yes	No	0	9	9
43	R:R:F55	R:R:R118	11.6203	4.28	Yes	Yes	1	8	9
44	R:R:R118	R:R:Y370	18.9183	6.17	Yes	Yes	1	9	9
45	R:R:L369	R:R:Y370	74.5872	3.52	Yes	Yes	0	9	9
46	R:R:C327	R:R:L369	69.4891	4.76	No	Yes	0	6	9
47	R:R:C327	R:R:I365	67.062	6.55	No	No	0	6	7
48	R:R:I365	R:R:L361	66.5798	8.56	No	No	0	7	5
49	R:R:F132	R:R:L58	60.6284	6.09	No	Yes	0	7	8
50	R:R:L113	R:R:L58	32.5668	4.15	No	Yes	0	7	8
51	R:R:L113	R:R:T144	30.8656	2.95	No	No	0	7	7
52	R:R:L109	R:R:T144	30.5774	2.95	No	No	0	6	7
53	R:R:L109	R:R:Y186	31.4419	4.69	No	No	0	6	8
54	R:R:S105	R:R:Y186	16.2972	13.99	No	No	0	7	8
55	R:R:F152	R:R:S105	17.4997	7.93	Yes	No	0	8	7
56	R:R:S151	R:R:Y186	16.2585	7.63	No	No	0	7	8
57	R:R:F152	R:R:S151	17.4997	7.93	Yes	No	0	8	7
58	R:R:I114	R:R:L58	54.9762	4.28	No	Yes	0	9	8
59	R:R:I114	R:R:Y370	53.2971	4.84	No	Yes	1	9	9
60	R:R:L62	R:R:Y370	100	3.52	Yes	Yes	1	9	9
61	R:R:L62	R:R:T110	12.5291	7.37	Yes	No	0	9	8
62	R:R:N61	R:R:T110	10.4677	10.24	No	No	0	9	8
63	R:R:N362	R:R:S107	50.7647	5.96	Yes	No	0	9	9
64	R:R:L62	R:R:S107	50.9143	4.5	Yes	No	0	9	9
65	R:R:N362	R:R:N366	50.7647	13.62	Yes	No	0	9	9
66	R:R:L62	R:R:N366	50.9143	6.87	Yes	No	0	9	9
67	R:R:F197	R:R:L116	25.1081	9.74	Yes	No	0	7	6
68	R:R:L116	R:R:L120	27.1196	4.15	No	No	0	6	5
69	R:R:L120	R:R:V131	55.9404	4.47	No	No	0	5	5
70	R:R:F132	R:R:V131	57.8632	7.87	No	No	0	7	5
71	R:R:R118	R:R:Y198	10.3513	8.23	Yes	Yes	0	9	9
72	R:R:H124	R:R:L127	24.9363	5.14	Yes	No	0	5	5
73	R:R:L120	R:R:L127	26.9589	5.54	No	No	0	5	5
74	R:R:F197	R:R:Y119	17.0176	8.25	Yes	Yes	0	7	9
75	R:R:H124	R:R:Y119	16.8735	8.71	Yes	Yes	7	5	9
76	R:R:L200	R:R:Y119	21.1903	10.55	No	Yes	0	6	9
77	R:R:D171	R:R:I160	15.6544	5.6	No	No	0	7	3
78	R:R:F9	R:R:I160	17.339	6.28	Yes	No	0	7	3
79	R:R:D171	R:R:I173	12.252	7	No	No	0	7	4
80	R:R:I173	R:R:R176	10.5342	3.76	No	Yes	0	4	4
81	R:R:M183	R:R:N339	16.397	4.21	No	Yes	0	8	7
82	R:R:L336	R:R:M183	15.2887	2.83	No	No	0	7	8
83	R:R:F187	R:R:L336	14.2802	4.87	Yes	No	0	8	7
84	R:R:L330	R:R:L361	18.7077	1.38	No	No	0	5	5
85	R:R:L330	R:R:L358	17.3834	1.38	No	No	0	5	9
86	R:R:L358	R:R:P334	16.2252	3.28	No	No	0	9	9
87	R:R:I333	R:R:P334	15.9481	3.39	Yes	No	0	7	9
88	R:R:F187	R:R:I333	14.2802	5.02	Yes	Yes	0	8	7
89	R:R:C321	R:R:Y198	10.6506	9.41	No	Yes	0	8	9
90	R:R:H352	R:R:N339	17.4	7.65	Yes	Yes	0	4	7
91	R:R:Q48	R:R:S383	17.3113	1.44	Yes	No	0	7	6
92	R:R:R387	R:R:S383	15.3164	1.32	No	No	0	7	6
93	R:R:R387	R:R:S391	10.9941	1.32	No	No	0	7	7
94	R:R:N357	R:R:W26	37.2326	5.65	Yes	Yes	2	8	5
95	R:R:F335	R:R:N339	18.813	13.29	Yes	Yes	8	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8J1A_nogp

PDB Summary
PDB	8J1A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	268
Number of Links	280
Number of Hubs	36
Number of Links mediated by Hubs	142
Number of Communities	9
Number of Nodes involved in Communities	39
Number of Links involved in Communities	44

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	47789
Length Of Smallest Path	3
Average Path Length	14.8344
Length of Longest Path	37
Minimum Path Strength	1.31
Average Path Strength	6.1725
Maximum Path Strength	18.86
Minimum Path Correlation	0.7
Average Path Correlation	0.941835
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	54.8039
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.6812
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • urotensin II receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide signaling pathway • receptor complex • tertiary granule membrane • intracellular vesicle • tertiary granule • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • secretory granule • secretory vesicle • secretory granule membrane • specific granule membrane • specific granule
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NQS5
Sequence	>8J1A_nogp_Chain_R N F S C Y H E S V L G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q P K L R T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H L H W R T G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H P K L F P Q V F S A K G I V L A L V S T W V V G V A S F A P L W P I Y I L V P V V C T C S F D R I R G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K L G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A R V Q A P R V V H M L A A N L T W L N G C I N P V L Y A A M N R Q F R Q A Y G S I L K R G P R S F H R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J18	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-	Gi1/β1/γ2	2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J18 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-		2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A	A	Orphan	Orphan	GPR84	Homo sapiens	-	-	Gi1/β1/γ2	3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	-	-		3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8G05	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-	Gi1/β1/γ2	3	2023-11-01	doi.org/10.1038/s41467-023-41201-0
	8G05 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-		3	2023-11-01	doi.org/10.1038/s41467-023-41201-0

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