psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L100	8.66	Yes	No	2	0	8
2	L:L:?1	R:R:F101	9.53	Yes	Yes	2	0	7
3	L:L:?1	R:R:N104	15.04	Yes	No	0	0	7
4	L:L:?1	R:R:I108	4.47	Yes	No	2	0	8
5	L:L:?1	R:R:F152	6.67	Yes	Yes	2	0	8
6	L:L:?1	R:R:Y186	10.09	Yes	Yes	2	0	8
7	L:L:?1	R:R:F335	20.01	Yes	Yes	2	0	8
8	L:L:?1	R:R:L336	5.42	Yes	No	0	0	7
9	L:L:?1	R:R:T359	11.53	Yes	No	2	0	8
10	R:R:A90	R:R:F9	4.16	No	Yes	0	4	7
11	R:R:H85	R:R:S10	6.97	No	No	0	4	8
12	R:R:C11	R:R:L84	4.76	No	No	0	5	5
13	R:R:C11	R:R:C166	7.28	No	No	0	5	3
14	R:R:E14	R:R:R349	12.79	No	Yes	0	6	1
15	R:R:L17	R:R:V350	5.96	No	No	0	4	3
16	R:R:G18	R:R:Y21	5.79	No	No	0	1	4
17	R:R:V22	R:R:Y19	7.57	No	Yes	0	5	5
18	R:R:V350	R:R:Y19	6.31	No	Yes	0	3	5
19	R:R:N357	R:R:Y19	10.47	No	Yes	0	8	5
20	R:R:R20	R:R:Y21	22.64	No	No	0	7	4
21	R:R:L84	R:R:R20	9.72	No	No	0	5	7
22	R:R:S25	R:R:V22	4.85	No	No	0	4	5
23	R:R:A23	R:R:Y81	8.01	No	No	0	7	5
24	R:R:A23	R:R:N357	4.69	No	No	0	7	8
25	R:R:G27	R:R:W360	4.22	No	Yes	0	5	8
26	R:R:C364	R:R:T33	5.07	No	Yes	0	6	4
27	R:R:T35	R:R:T71	4.71	No	No	0	7	5
28	R:R:G37	R:R:V36	5.52	No	No	0	9	5
29	R:R:L40	R:R:V36	4.47	No	No	0	8	5
30	R:R:G37	R:R:P367	4.06	No	No	0	9	9
31	R:R:N38	R:R:T63	7.31	Yes	No	0	9	9
32	R:R:D66	R:R:N38	6.73	Yes	Yes	0	9	9
33	R:R:L67	R:R:N38	5.49	No	Yes	0	7	9
34	R:R:N38	R:R:P367	6.52	Yes	No	0	9	9
35	R:R:L40	R:R:Y381	10.55	No	Yes	0	8	8
36	R:R:T41	R:R:T63	9.42	No	No	0	9	9
37	R:R:A371	R:R:T41	5.03	No	No	0	8	9
38	R:R:L42	R:R:L64	4.15	No	No	0	7	6
39	R:R:A44	R:R:Y381	5.34	No	Yes	0	8	8
40	R:R:L45	R:R:R52	6.07	No	No	0	8	7
41	R:R:A60	R:R:L45	4.73	No	No	0	6	8
42	R:R:K50	R:R:Q48	4.07	No	Yes	0	6	7
43	R:R:A380	R:R:Q48	6.06	No	Yes	0	8	7
44	R:R:P49	R:R:R52	4.32	No	No	0	6	7
45	R:R:L51	R:R:N56	4.12	No	No	4	9	9
46	R:R:F377	R:R:L51	8.53	Yes	No	4	9	9
47	R:R:N56	R:R:T53	10.24	No	No	0	9	7
48	R:R:F55	R:R:I59	5.02	Yes	No	0	8	8
49	R:R:F55	R:R:R118	4.28	Yes	Yes	1	8	9
50	R:R:F128	R:R:F55	5.36	Yes	Yes	1	8	8
51	R:R:F377	R:R:N56	9.67	Yes	No	4	9	9
52	R:R:I137	R:R:L57	7.14	Yes	No	0	7	5
53	R:R:L113	R:R:L58	4.15	No	Yes	0	7	8
54	R:R:I114	R:R:L58	4.28	No	Yes	0	9	8
55	R:R:F132	R:R:L58	6.09	Yes	Yes	0	7	8
56	R:R:F377	R:R:I59	5.02	Yes	No	0	9	8
57	R:R:N61	R:R:V106	4.43	Yes	No	5	9	8
58	R:R:N61	R:R:T110	4.39	Yes	No	0	9	8
59	R:R:L141	R:R:N61	5.49	No	Yes	0	8	9
60	R:R:N61	R:R:T144	7.31	Yes	No	0	9	7
61	R:R:N61	R:R:W145	9.04	Yes	No	5	9	9
62	R:R:D66	R:R:L62	9.5	Yes	No	1	9	9
63	R:R:L62	R:R:T110	11.79	No	No	0	9	8
64	R:R:L62	R:R:N366	8.24	No	Yes	1	9	9
65	R:R:D66	R:R:S107	5.89	Yes	No	1	9	9
66	R:R:D66	R:R:N362	6.73	Yes	Yes	1	9	9
67	R:R:D66	R:R:G363	5.03	Yes	No	1	9	9
68	R:R:D66	R:R:N366	6.73	Yes	Yes	1	9	9
69	R:R:L67	R:R:T71	5.9	No	No	0	7	5
70	R:R:L73	R:R:Y69	4.69	No	Yes	0	8	8
71	R:R:Q74	R:R:Y69	5.64	Yes	Yes	3	8	8
72	R:R:S103	R:R:Y69	5.09	No	Yes	0	6	8
73	R:R:W360	R:R:Y69	8.68	Yes	Yes	3	8	8
74	R:R:L72	R:R:T71	7.37	No	No	0	5	5
75	R:R:F96	R:R:L73	12.18	Yes	No	0	6	8
76	R:R:L73	R:R:L99	4.15	No	No	0	8	5
77	R:R:Q74	R:R:V78	5.73	Yes	No	0	8	7
78	R:R:Q74	R:R:W360	8.76	Yes	Yes	3	8	8
79	R:R:F76	R:R:F92	10.72	No	No	0	6	4
80	R:R:F76	R:R:F96	7.5	No	Yes	0	6	6
81	R:R:S77	R:R:T167	6.4	No	No	0	7	4
82	R:R:D79	R:R:T80	4.34	No	No	0	6	6
83	R:R:D79	R:R:H83	11.35	No	No	7	6	5
84	R:R:D79	R:R:R87	4.76	No	No	7	6	4
85	R:R:T80	R:R:W86	7.28	No	Yes	0	6	8
86	R:R:C166	R:R:Y81	10.75	No	No	0	3	5
87	R:R:M353	R:R:Y81	4.79	No	No	0	5	5
88	R:R:H83	R:R:L82	7.71	No	No	0	5	5
89	R:R:H83	R:R:R87	5.64	No	No	7	5	4
90	R:R:T88	R:R:W86	12.13	No	Yes	0	6	8
91	R:R:F96	R:R:W86	7.02	Yes	Yes	6	6	8
92	R:R:L161	R:R:W86	5.69	No	Yes	0	4	8
93	R:R:C168	R:R:W86	14.37	No	Yes	6	9	8
94	R:R:F92	R:R:T88	7.78	No	No	0	4	6
95	R:R:F92	R:R:V95	5.24	No	No	0	4	5
96	R:R:C168	R:R:C93	7.28	No	No	0	9	9
97	R:R:R94	R:R:W156	15.99	No	No	0	6	6
98	R:R:C168	R:R:F96	4.19	No	Yes	6	9	6
99	R:R:G97	R:R:Y159	4.35	No	No	0	6	5
100	R:R:L98	R:R:W156	4.56	No	No	0	7	6
101	R:R:L98	R:R:Y159	5.86	No	No	0	7	5
102	R:R:F101	R:R:L100	6.09	Yes	No	2	7	8
103	R:R:F101	R:R:F152	13.93	Yes	Yes	2	7	8
104	R:R:F101	R:R:F170	7.5	Yes	No	0	7	6
105	R:R:N104	R:R:S103	4.47	No	No	0	7	6
106	R:R:N104	R:R:Y332	8.14	No	Yes	0	7	8
107	R:R:F152	R:R:S105	5.28	Yes	Yes	0	8	7
108	R:R:S105	R:R:Y186	6.36	Yes	Yes	0	7	8
109	R:R:V106	R:R:W145	14.71	No	No	5	8	9
110	R:R:N362	R:R:S107	7.45	Yes	No	1	9	9
111	R:R:I108	R:R:Y186	6.04	No	Yes	2	8	8
112	R:R:I108	R:R:Y332	15.71	No	Yes	0	8	8
113	R:R:L109	R:R:Y186	10.55	No	Yes	0	6	8
114	R:R:L111	R:R:N366	5.49	No	Yes	1	8	9
115	R:R:L111	R:R:Y370	5.86	No	Yes	1	8	9
116	R:R:C112	R:R:S193	6.89	No	No	0	6	7
117	R:R:I114	R:R:R118	5.01	No	Yes	1	9	9
118	R:R:I114	R:R:Y370	6.04	No	Yes	1	9	9
119	R:R:A115	R:R:F197	4.16	No	Yes	0	8	7
120	R:R:A115	R:R:Y198	5.34	No	Yes	0	8	9
121	R:R:L116	R:R:L120	6.92	No	No	0	6	5
122	R:R:F197	R:R:L116	9.74	Yes	No	0	7	6
123	R:R:R118	R:R:Y198	10.29	Yes	Yes	1	9	9
124	R:R:R118	R:R:Y370	8.23	Yes	Yes	1	9	9
125	R:R:A123	R:R:Y119	8.01	No	Yes	8	7	9
126	R:R:H124	R:R:Y119	8.71	Yes	Yes	8	5	9
127	R:R:F197	R:R:Y119	9.28	Yes	Yes	0	7	9
128	R:R:L200	R:R:Y119	8.21	No	Yes	0	6	9
129	R:R:L120	R:R:V131	4.47	No	No	0	5	5
130	R:R:F128	R:R:L121	17.05	Yes	No	0	8	8
131	R:R:I122	R:R:I201	7.36	No	No	0	8	9
132	R:R:A123	R:R:H124	4.39	No	Yes	8	7	5
133	R:R:H124	R:R:L127	7.71	Yes	No	0	5	5
134	R:R:F128	R:R:P129	4.33	Yes	No	0	8	6
135	R:R:F128	R:R:F132	12.86	Yes	Yes	1	8	7
136	R:R:Q130	R:R:V131	4.3	No	No	0	5	5
137	R:R:F132	R:R:V131	5.24	Yes	No	0	7	5
138	R:R:K135	R:R:L139	7.05	No	No	0	5	4
139	R:R:L182	R:R:S151	9.01	No	No	0	8	7
140	R:R:F152	R:R:L182	4.87	Yes	No	0	8	8
141	R:R:P154	R:R:Y178	5.56	No	No	0	7	8
142	R:R:L155	R:R:Y159	8.21	No	No	0	8	5
143	R:R:L155	R:R:Y178	4.69	No	No	0	8	8
144	R:R:P157	R:R:W156	4.05	No	No	0	5	6
145	R:R:I158	R:R:P157	5.08	No	No	0	5	5
146	R:R:I158	R:R:R174	6.26	No	No	0	5	5
147	R:R:D171	R:R:I160	8.4	No	No	0	7	3
148	R:R:S169	R:R:V162	6.46	No	No	0	4	3
149	R:R:H352	R:R:V164	5.54	No	No	0	4	2
150	R:R:F170	R:R:R172	16.03	No	Yes	0	6	5
151	R:R:F170	R:R:T179	15.56	No	No	0	6	6
152	R:R:D171	R:R:I173	8.4	No	No	0	7	4
153	R:R:D171	R:R:R174	7.15	No	No	0	7	5
154	R:R:N339	R:R:R172	4.82	No	Yes	0	7	5
155	R:R:I173	R:R:R344	6.26	No	No	0	4	3
156	R:R:P177	R:R:R176	10.09	No	No	0	3	4
157	R:R:A343	R:R:R176	4.15	No	No	0	5	4
158	R:R:L182	R:R:Y178	10.55	No	No	0	8	8
159	R:R:M183	R:R:N339	7.01	No	No	0	8	7
160	R:R:I340	R:R:M183	7.29	Yes	No	0	6	8
161	R:R:F187	R:R:L191	6.09	Yes	No	0	8	6
162	R:R:F187	R:R:I333	5.02	Yes	No	0	8	7
163	R:R:F187	R:R:L337	7.31	Yes	No	0	8	6
164	R:R:F328	R:R:G190	4.52	No	No	0	9	8
165	R:R:F197	R:R:S193	5.28	Yes	No	0	7	7
166	R:R:C321	R:R:Y198	5.38	No	Yes	0	8	9
167	R:R:V324	R:R:Y198	10.09	No	Yes	1	8	9
168	R:R:Y198	R:R:Y370	4.96	Yes	Yes	1	9	9
169	R:R:H202	R:R:T318	9.58	No	No	0	6	7
170	R:R:K206	R:R:R203	11.14	No	No	9	6	5
171	R:R:R203	R:R:R207	9.6	No	No	0	5	5
172	R:R:Q210	R:R:R203	4.67	No	No	9	6	5
173	R:R:Q204	R:R:R207	5.84	No	No	0	6	5
174	R:R:K206	R:R:Q210	12.2	No	No	9	6	6
175	R:R:Q214	R:R:Y215	14.65	No	No	0	3	6
176	R:R:K316	R:R:R319	13.61	No	No	0	8	6
177	R:R:M320	R:R:M373	5.78	No	No	0	8	7
178	R:R:V324	R:R:Y370	6.31	No	Yes	1	8	9
179	R:R:T359	R:R:Y332	4.99	No	Yes	0	8	8
180	R:R:N362	R:R:Y332	9.3	Yes	Yes	0	9	8
181	R:R:F335	R:R:N339	16.92	Yes	No	0	8	7
182	R:R:F335	R:R:T359	5.19	Yes	No	2	8	8
183	R:R:H352	R:R:L338	12.86	No	No	0	4	5
184	R:R:D342	R:R:H352	7.56	No	No	0	4	4
185	R:R:M353	R:R:R349	7.44	No	Yes	0	5	1
186	R:R:N357	R:R:W360	14.69	No	Yes	0	8	8
187	R:R:I365	R:R:L361	5.71	No	No	0	7	5
188	R:R:G363	R:R:N362	5.09	No	Yes	1	9	9
189	R:R:N362	R:R:N366	13.62	Yes	Yes	1	9	9
190	R:R:N366	R:R:Y370	4.65	Yes	Yes	1	9	9
191	R:R:F377	R:R:N374	6.04	Yes	No	0	9	9
192	R:R:L385	R:R:Y381	5.86	No	Yes	0	7	8
193	R:R:I384	R:R:S391	6.19	No	No	0	7	7
194	R:R:G388	R:R:P389	4.06	No	No	10	4	3
195	R:R:G388	R:R:R390	7.51	No	Yes	10	4	5
196	R:R:P389	R:R:R390	8.65	No	Yes	10	3	5
197	R:R:H393	R:R:R390	6.77	No	Yes	0	5	5
198	R:R:R390	R:R:R394	4.26	Yes	No	0	5	8
199	R:R:L395	R:R:R394	7.29	No	No	0	6	8
200	R:R:F9	R:R:W86	4.01	Yes	Yes	0	7	8
201	R:R:F96	R:R:S77	3.96	Yes	No	0	6	7
202	R:R:N374	R:R:Q376	3.96	No	No	0	9	7
203	R:R:R172	R:R:S169	3.95	Yes	No	0	5	4
204	R:R:C70	R:R:G34	3.92	No	No	0	7	8
205	R:R:R349	R:R:V164	3.92	Yes	No	0	1	2
206	R:R:R172	R:R:V165	3.92	Yes	No	0	5	4
207	R:R:V16	R:R:Y12	3.79	No	No	0	6	8
208	R:R:V194	R:R:Y198	3.79	No	Yes	0	8	9
209	R:R:I137	R:R:R54	3.76	Yes	No	0	7	7
210	R:R:G148	R:R:S105	3.71	No	Yes	0	8	7
211	L:L:?1	R:R:A356	3.7	Yes	No	0	0	6
212	R:R:V30	R:R:W360	3.68	No	Yes	0	6	8
213	R:R:F377	R:R:L45	3.65	Yes	No	0	9	8
214	R:R:F325	R:R:L191	3.65	No	No	0	8	6
215	R:R:F328	R:R:L191	3.65	No	No	0	9	6
216	R:R:G34	R:R:T33	3.64	No	Yes	0	8	4
217	R:R:G89	R:R:T88	3.64	No	No	0	7	6
218	R:R:I201	R:R:Y119	3.63	No	Yes	0	9	9
219	R:R:I384	R:R:Y381	3.63	No	Yes	0	7	8
220	R:R:Q379	R:R:R378	3.5	No	No	0	5	9
221	R:R:C364	R:R:V30	3.42	No	No	0	6	6
222	R:R:G190	R:R:L189	3.42	No	No	0	8	5
223	R:R:A65	R:R:V106	3.39	No	No	0	8	8
224	R:R:I333	R:R:P334	3.39	No	No	0	7	9
225	R:R:L358	R:R:P334	3.28	No	No	0	9	9
226	R:R:V28	R:R:V78	3.21	No	No	0	4	7
227	R:R:V164	R:R:V345	3.21	No	No	0	2	4
228	R:R:T33	R:R:V29	3.17	Yes	No	0	4	4
229	R:R:C112	R:R:L189	3.17	No	No	0	6	5
230	R:R:C327	R:R:L369	3.17	No	Yes	0	6	9
231	R:R:P75	R:R:Q74	3.16	No	Yes	0	9	8
232	R:R:A140	R:R:L113	3.15	No	No	0	7	7
233	R:R:A347	R:R:D342	3.09	No	No	0	5	4
234	R:R:I340	R:R:T180	3.04	Yes	No	0	6	6
235	R:R:F55	R:R:G117	3.01	Yes	No	1	8	9
236	R:R:F128	R:R:G117	3.01	Yes	No	1	8	9
237	R:R:F132	R:R:G117	3.01	Yes	No	1	7	9
238	R:R:F325	R:R:G195	3.01	No	No	0	8	5
239	R:R:L68	R:R:S103	3	No	No	0	7	6
240	R:R:L361	R:R:S331	3	No	No	0	5	8
241	R:R:L109	R:R:V147	2.98	No	No	0	6	4
242	R:R:N362	R:R:S331	2.98	Yes	No	0	9	8
243	R:R:L338	R:R:V351	2.98	No	No	0	5	5
244	R:R:L42	R:R:T63	2.95	No	No	0	7	9
245	R:R:I384	R:R:I47	2.94	No	No	0	7	5
246	R:R:Q48	R:R:S383	2.89	Yes	No	0	7	6
247	R:R:P163	R:R:R349	2.88	No	Yes	0	3	1
248	R:R:I47	R:R:L395	2.85	No	No	0	5	6
249	R:R:I137	R:R:L58	2.85	Yes	Yes	0	7	8
250	R:R:I137	R:R:L141	2.85	Yes	No	0	7	8
251	R:R:I196	R:R:L200	2.85	No	No	0	5	6
252	R:R:I340	R:R:L341	2.85	Yes	No	0	6	5
253	R:R:H13	R:R:V16	2.77	No	No	0	6	6
254	R:R:A134	R:R:R54	2.77	No	No	0	3	7
255	R:R:L330	R:R:L358	2.77	No	No	0	5	9
256	R:R:L330	R:R:L361	2.77	No	No	0	5	5
257	R:R:A355	R:R:F335	2.77	No	Yes	0	6	8
258	R:R:I47	R:R:Q48	2.74	No	Yes	0	5	7
259	R:R:I122	R:R:Q204	2.74	No	No	0	8	6
260	R:R:F187	R:R:V188	2.62	Yes	No	0	8	6
261	R:R:H202	R:R:K206	2.62	No	No	0	6	6
262	R:R:R176	R:R:T180	2.59	No	No	0	4	6
263	R:R:F322	R:R:T318	2.59	No	No	0	6	7
264	R:R:H13	R:R:L17	2.57	No	No	0	6	4
265	R:R:V30	R:R:W26	2.45	No	No	0	6	5
266	R:R:F9	R:R:N8	2.42	Yes	No	0	7	5
267	R:R:L354	R:R:Y19	2.34	No	Yes	0	4	5
268	R:R:L43	R:R:Y381	2.34	No	Yes	0	5	8
269	R:R:L369	R:R:Y370	2.34	Yes	Yes	0	9	9
270	R:R:F9	R:R:H85	2.26	Yes	No	0	7	4
271	R:R:R375	R:R:R378	2.13	No	No	0	5	9
272	R:R:G175	R:R:P177	2.03	No	No	0	7	3
273	R:R:A153	R:R:P154	1.87	No	No	0	5	7
274	R:R:A347	R:R:P348	1.87	No	No	0	5	6
275	R:R:G136	R:R:S133	1.86	No	No	0	7	7
276	R:R:G184	R:R:I340	1.76	No	Yes	0	5	6
277	R:R:G136	R:R:K135	1.74	No	No	0	7	5
278	R:R:G382	R:R:K386	1.74	No	No	0	5	4
279	R:R:A102	R:R:S105	1.71	No	Yes	0	6	7
280	R:R:A140	R:R:S143	1.71	No	No	0	7	3
281	R:R:C321	R:R:V317	1.71	No	No	0	8	8
282	R:R:A153	R:R:V149	1.7	No	No	0	5	5
283	R:R:A372	R:R:V368	1.7	No	No	0	5	6
284	R:R:A329	R:R:I333	1.62	No	No	0	6	7
285	R:R:V24	R:R:V28	1.6	No	No	0	6	4
286	R:R:V138	R:R:V142	1.6	No	No	0	3	5
287	R:R:V205	R:R:V317	1.6	No	No	0	8	8
288	R:R:T33	R:R:V32	1.59	Yes	No	0	4	5
289	R:R:A323	R:R:L369	1.58	No	Yes	0	7	9
290	R:R:I196	R:R:S192	1.55	No	No	0	5	4
291	R:R:I365	R:R:V368	1.54	No	No	0	7	6
292	R:R:H124	R:R:P125	1.53	Yes	No	0	5	8
293	R:R:A31	R:R:Q74	1.52	No	Yes	0	6	8
294	R:R:L40	R:R:V39	1.49	No	No	0	8	5
295	R:R:L139	R:R:V138	1.49	No	No	0	4	3
296	R:R:I181	R:R:I185	1.47	No	No	0	5	6
297	R:R:F392	R:R:P389	1.44	No	No	0	8	3
298	R:R:K126	R:R:L127	1.41	No	No	0	6	5
299	R:R:L369	R:R:M320	1.41	Yes	No	0	9	8
300	R:R:K386	R:R:L385	1.41	No	No	0	4	7
301	R:R:D213	R:R:K216	1.38	No	No	0	3	5
302	R:R:D213	R:R:L212	1.36	No	No	0	3	4
303	R:R:D342	R:R:Q346	1.31	No	No	0	4	2
304	R:R:Q376	R:R:R375	1.17	No	No	0	7	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.512	10	2	0
2	R:R:F9	3.2125	4	0	7
3	R:R:Y19	6.6725	4	0	5
4	R:R:T33	3.3675	4	0	4
5	R:R:N38	6.5125	4	0	9
6	R:R:Q48	3.94	4	0	7
7	R:R:F55	4.4175	4	1	8
8	R:R:L58	4.3425	4	0	8
9	R:R:N61	6.132	5	5	9
10	R:R:D66	6.76833	6	1	9
11	R:R:Y69	6.025	4	3	8
12	R:R:Q74	4.962	5	3	8
13	R:R:W86	8.41667	6	6	8
14	R:R:F96	6.97	5	6	6
15	R:R:F101	9.2625	4	2	7
16	R:R:S105	4.265	4	0	7
17	R:R:R118	6.9525	4	1	9
18	R:R:Y119	7.568	5	8	9
19	R:R:H124	5.585	4	8	5
20	R:R:F128	8.522	5	1	8
21	R:R:F132	6.8	4	1	7
22	R:R:I137	4.15	4	0	7
23	R:R:F152	7.6875	4	2	8
24	R:R:R172	7.18	4	0	5
25	R:R:Y186	8.26	4	2	8
26	R:R:F187	5.26	4	0	8
27	R:R:F197	7.115	4	0	7
28	R:R:Y198	6.64167	6	1	9
29	R:R:Y332	9.535	4	0	8
30	R:R:F335	11.2225	4	2	8
31	R:R:I340	3.735	4	0	6
32	R:R:R349	6.7575	4	0	1
33	R:R:W360	8.006	5	3	8
34	R:R:N362	7.52833	6	1	9
35	R:R:N366	7.746	5	1	9
36	R:R:L369	2.125	4	0	9
37	R:R:Y370	5.48429	7	1	9
38	R:R:F377	6.582	5	4	9
39	R:R:Y381	5.544	5	0	8
40	R:R:R390	6.7975	4	10	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N104	31.509	15.04	Yes	No	0	0	7
2	R:R:N104	R:R:S103	58.5119	4.47	No	No	0	7	6
3	R:R:S103	R:R:Y69	57.4767	5.09	No	Yes	0	6	8
4	R:R:L73	R:R:Y69	23.5623	4.69	No	Yes	0	8	8
5	R:R:F96	R:R:L73	21.7659	12.18	Yes	No	0	6	8
6	R:R:F96	R:R:W86	14.0552	7.02	Yes	Yes	6	6	8
7	R:R:W360	R:R:Y69	36.6013	8.68	Yes	Yes	3	8	8
8	R:R:N357	R:R:W360	29.5414	14.69	No	Yes	0	8	8
9	R:R:A23	R:R:N357	20.8563	4.69	No	No	0	7	8
10	R:R:A23	R:R:Y81	19.9391	8.01	No	No	0	7	5
11	R:R:M353	R:R:Y81	13.3054	4.79	No	No	0	5	5
12	R:R:M353	R:R:R349	12.3273	7.44	No	Yes	0	5	1
13	R:R:N104	R:R:Y332	57.4653	8.14	No	Yes	0	7	8
14	R:R:N362	R:R:Y332	100	9.3	Yes	Yes	0	9	8
15	R:R:D66	R:R:N362	33.0695	6.73	Yes	Yes	1	9	9
16	R:R:D66	R:R:N38	38.1732	6.73	Yes	Yes	0	9	9
17	L:L:?1	R:R:I108	15.4405	4.47	Yes	No	2	0	8
18	R:R:I108	R:R:Y332	19.1437	15.71	No	Yes	0	8	8
19	L:L:?1	R:R:T359	15.3873	11.53	Yes	No	2	0	8
20	R:R:T359	R:R:Y332	24.6622	4.99	No	Yes	0	8	8
21	R:R:N38	R:R:P367	28.1256	6.52	Yes	No	0	9	9
22	R:R:G37	R:R:P367	27.079	4.06	No	No	0	9	9
23	R:R:G37	R:R:V36	26.0247	5.52	No	No	0	9	5
24	R:R:L40	R:R:V36	24.9629	4.47	No	No	0	8	5
25	R:R:L40	R:R:Y381	22.8011	10.55	No	Yes	0	8	8
26	R:R:N362	R:R:N366	60.3768	13.62	Yes	Yes	1	9	9
27	R:R:N366	R:R:Y370	65.0733	4.65	Yes	Yes	1	9	9
28	R:R:R118	R:R:Y370	18.9458	8.23	Yes	Yes	1	9	9
29	R:R:F55	R:R:R118	21.9486	4.28	Yes	Yes	1	8	9
30	R:R:F55	R:R:I59	18.5766	5.02	Yes	No	0	8	8
31	R:R:F377	R:R:I59	17.2978	5.02	Yes	No	0	9	8
32	R:R:I384	R:R:Y381	16.255	3.63	No	Yes	0	7	8
33	R:R:I384	R:R:I47	14.059	2.94	No	No	0	7	5
34	R:R:I114	R:R:Y370	13.2788	6.04	No	Yes	1	9	9
35	R:R:I114	R:R:L58	14.3787	4.28	No	Yes	0	9	8
36	R:R:L62	R:R:T110	13.412	11.79	No	No	0	9	8
37	R:R:N61	R:R:T110	11.6042	4.39	Yes	No	0	9	8
38	L:L:?1	R:R:F152	41.7659	6.67	Yes	Yes	2	0	8
39	R:R:F152	R:R:L182	39.9125	4.87	Yes	No	0	8	8
40	R:R:L182	R:R:Y178	35.8402	10.55	No	No	0	8	8
41	R:R:L155	R:R:Y178	27.6042	4.69	No	No	0	8	8
42	R:R:L155	R:R:Y159	25.5262	8.21	No	No	0	8	5
43	R:R:L98	R:R:Y159	21.3473	5.86	No	No	0	7	5
44	R:R:L98	R:R:W156	19.2464	4.56	No	No	0	7	6
45	R:R:Y198	R:R:Y370	31.1475	4.96	Yes	Yes	1	9	9
46	R:R:A115	R:R:Y198	30.7897	5.34	No	Yes	0	8	9
47	R:R:A115	R:R:F197	29.8116	4.16	No	Yes	0	8	7
48	R:R:F197	R:R:Y119	23.4253	9.28	Yes	Yes	0	7	9
49	R:R:I201	R:R:Y119	12.6698	3.63	No	Yes	0	9	9
50	R:R:I122	R:R:I201	11.4329	7.36	No	No	0	8	9
51	R:R:P157	R:R:W156	15.0219	4.05	No	No	0	5	6
52	R:R:I158	R:R:P157	12.8982	5.08	No	No	0	5	5
53	R:R:I158	R:R:R174	10.7669	6.26	No	No	0	5	5
54	R:R:F335	R:R:N339	13.3245	16.92	Yes	No	0	8	7
55	R:R:N362	R:R:S331	18.0856	2.98	Yes	No	0	9	8
56	R:R:L361	R:R:S331	16.9743	3	No	No	0	5	8
57	R:R:L330	R:R:L361	12.4833	2.77	No	No	0	5	5
58	R:R:L330	R:R:L358	11.3492	2.77	No	No	0	5	9
59	R:R:L358	R:R:P334	10.215	3.28	No	No	0	9	9
60	R:R:I122	R:R:Q204	10.1922	2.74	No	No	0	8	6
61	R:R:D66	R:R:N366	10.7288	6.73	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L100	8.66	2	Yes	No	0	8	0	1
L:L:?1	R:R:F101	9.53	2	Yes	Yes	0	7	0	1
L:L:?1	R:R:N104	15.04	2	Yes	No	0	7	0	1
L:L:?1	R:R:I108	4.47	2	Yes	No	0	8	0	1
L:L:?1	R:R:F152	6.67	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y186	10.09	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:F335	20.01	2	Yes	Yes	0	8	0	1
L:L:?1	R:R:L336	5.42	2	Yes	No	0	7	0	1
L:L:?1	R:R:T359	11.53	2	Yes	No	0	8	0	1
R:R:F101	R:R:L100	6.09	2	Yes	No	7	8	1	1
R:R:F101	R:R:F152	13.93	2	Yes	Yes	7	8	1	1
R:R:F101	R:R:F170	7.5	2	Yes	No	7	6	1	2
R:R:N104	R:R:S103	4.47	0	No	No	7	6	1	2
R:R:N104	R:R:Y332	8.14	0	No	Yes	7	8	1	2
R:R:F152	R:R:S105	5.28	2	Yes	Yes	8	7	1	2
R:R:S105	R:R:Y186	6.36	0	Yes	Yes	7	8	2	1
R:R:I108	R:R:Y186	6.04	2	No	Yes	8	8	1	1
R:R:I108	R:R:Y332	15.71	2	No	Yes	8	8	1	2
R:R:L109	R:R:Y186	10.55	0	No	Yes	6	8	2	1
R:R:F152	R:R:L182	4.87	2	Yes	No	8	8	1	2
R:R:T359	R:R:Y332	4.99	2	No	Yes	8	8	1	2
R:R:F335	R:R:N339	16.92	2	Yes	No	8	7	1	2
R:R:F335	R:R:T359	5.19	2	Yes	No	8	8	1	1
L:L:?1	R:R:A356	3.7	2	Yes	No	0	6	0	1
R:R:A355	R:R:F335	2.77	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8J18_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.04
Number of Linked Nodes	279
Number of Links	304
Number of Hubs	40
Number of Links mediated by Hubs	157
Number of Communities	10
Number of Nodes involved in Communities	48
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	62
Number Of Links MetaPath	61
Number of Shortest Paths	46133
Length Of Smallest Path	3
Average Path Length	13.5505
Length of Longest Path	32
Minimum Path Strength	1.37
Average Path Strength	6.73249
Maximum Path Strength	18.465
Minimum Path Correlation	0.71
Average Path Correlation	0.93505
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	56.007
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.7028
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	HXD
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	HXD
Name	(3R)-3-HYDROXYDODECANOIC ACID
Synonyms	3-OH-DODECANOATE
Identifier
Formula	C12 H24 O3
Molecular Weight	216.317
SMILES
PubChem	5312804
Formal Charge	0
Total Atoms	39
Total Chiral Atoms	1
Total Bonds	38
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9NQS5
Sequence	>8J18_nogp_Chain_R N F S C Y H E S V L G Y R Y V A V S W G V V V A V T G T V G N V L T L L A L A I Q P K L R T R F N L L I A N L T L A D L L Y C T L L Q P F S V D T Y L H L H W R T G A T F C R V F G L L L F A S N S V S I L T L C L I A L G R Y L L I A H P K L F P Q V F S A K G I V L A L V S T W V V G V A S F A P L W P I Y I L V P V V C T C S F D R I R G R P Y T T I L M G I Y F V L G L S S V G I F Y C L I H R Q V K R A A Q A L D Q Y K L G K V T R M C F A V F L C F A L S Y I P F L L L N I L D A R V Q A P R V V H M L A A N L T W L N G C I N P V L Y A A M N R Q F R Q A Y G S I L K R G P R S F H R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8J18	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-	Gi1/β1/γ2	2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J18 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	(3R)-3-Hydroxydodecanoic acid	-		2.89	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-	Gi1/β1/γ2	3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J19 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	LY237	-		3.23	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A	A	Orphan	Orphan	GPR84	Homo sapiens	-	-	Gi1/β1/γ2	3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8J1A (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	-	-		3.24	2023-06-21	doi.org/10.1038/s41467-023-38985-6
	8G05	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-	Gi1/β1/γ2	3	2023-11-01	doi.org/10.1038/s41467-023-41201-0
	8G05 (No Gprot)	A	Orphan	Orphan	GPR84	Homo sapiens	6-OAU	-		3	2023-11-01	doi.org/10.1038/s41467-023-41201-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J18_nogp.zip

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