Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.925409
2A:A:V34 4.775435
3A:A:L36 4.44437
4A:A:L37 6.62419
5A:A:L38 7.31438
6A:A:L39 4.6325419
7A:A:S44 1.75409
8A:A:K46 4.14539
9A:A:I49 4.1375437
10A:A:M53 5.765438
11A:A:I184 5.0225419
12A:A:F189 7.772539
13A:A:F191 8.3825435
14A:A:F196 6.40833637
15A:A:M198 6.4825437
16A:A:F199 7.28515
17A:A:Q204 4.56833619
18A:A:S206 3.7075418
19A:A:K210 5.41719
20A:A:W211 5.55167619
21A:A:H213 7.1475418
22A:A:C214 3.662517
23A:A:F215 4.96375819
24A:A:I221 4.155618
25A:A:I222 3.575637
26A:A:C224 3.1625407
27A:A:L227 5.53417
28A:A:S228 4.02754109
29A:A:Y230 4.7125418
30A:A:R242 5.145409
31A:A:M243 3.856518
32A:A:F250 6.84571719
33A:A:I253 3.375418
34A:A:C254 4.35515
35A:A:W258 6.76167615
36A:A:F259 5.71333619
37A:A:I265 3.3025408
38A:A:L266 4.806519
39A:A:F267 3.4875839
40A:A:L268 5.416518
41A:A:L273 3.9465106
42A:A:F274 5.152509
43A:A:I278 4.506516
44A:A:L283 3.45417
45A:A:C286 6.655416
46A:A:Y287 6.17571717
47A:A:Y296 5.81404
48A:A:E298 3.0125404
49A:A:I303 3.62407
50A:A:F307 4.16833618
51A:A:N311 4.6925418
52A:A:I319 4.0275415
53A:A:Y320 6.05737
54A:A:T321 6.815415
55A:A:F323 5.118514
56A:A:T324 6.0925439
57A:A:N331 3.44667638
58A:A:Q333 6.706535
59A:A:F334 7.03433
60A:A:F336 5.572538
61A:A:V339 5.0825438
62A:A:D341 10.1438
63A:A:L348 6.7375429
64A:A:L353 4.658527
65B:B:D27 5.4375408
66B:B:V40 3.47513
67B:B:M45 4.4375414
68B:B:L51 6.866519
69B:B:H54 7.73667619
70B:B:Y59 9.035418
71B:B:M61 5.1425416
72B:B:W63 6.67167617
73B:B:L69 4.245405
74B:B:L70 6.048515
75B:B:V71 4.6075458
76B:B:D76 5.534519
77B:B:K78 5.136518
78B:B:L79 4.43457
79B:B:I80 6.695618
80B:B:I81 4.13833657
81B:B:W82 9.59286719
82B:B:S84 4.105415
83B:B:K89 7.24167619
84B:B:I93 4.032557
85B:B:L95 4.81558
86B:B:W99 6.575819
87B:B:Y105 4.82143756
88B:B:N110 7.23754114
89B:B:Y111 7.27754114
90B:B:C114 4.228558
91B:B:L117 3.12667619
92B:B:N119 3.38409
93B:B:C121 3.34468
94B:B:I123 3.804506
95B:B:Y124 4.26286756
96B:B:L126 4.185455
97B:B:E130 3.78754133
98B:B:V133 5.3575454
99B:B:E138 3.3275456
100B:B:L139 4.825609
101B:B:H142 6.15429769
102B:B:Y145 5.80125818
103B:B:L146 4.73467
104B:B:R150 6.6225446
105B:B:F151 5.35667609
106B:B:L152 4.59403
107B:B:D154 6.52254116
108B:B:I157 5.1975407
109B:B:T159 4.256569
110B:B:D163 7.858569
111B:B:L168 4.3075446
112B:B:W169 9.97568
113B:B:D170 6.8475449
114B:B:F180 7.42333647
115B:B:H183 6.66571749
116B:B:D186 4.57667619
117B:B:L190 4.674545
118B:B:F199 6.99333649
119B:B:V200 5.826516
120B:B:C204 5.026517
121B:B:D205 5.98549
122B:B:K209 7.676546
123B:B:L210 4.755415
124B:B:W211 10.5683648
125B:B:Q220 6.558517
126B:B:F222 5.89333618
127B:B:H225 8.8525819
128B:B:D228 7.245419
129B:B:I229 5.5175417
130B:B:I232 4.06286718
131B:B:F234 5.19833615
132B:B:F235 5.3225816
133B:B:P236 6.725417
134B:B:F241 6.27143716
135B:B:T243 5.238518
136B:B:D246 6.145419
137B:B:D247 7.21667619
138B:B:T249 6.488516
139B:B:R251 10.6333618
140B:B:F253 6.625616
141B:B:L255 3.56416
142B:B:D258 9.25417
143B:B:M262 4.8375414
144B:B:Y264 4.48167615
145B:B:I269 3.672514
146B:B:S277 3.695415
147B:B:F278 4.916517
148B:B:R283 6.61667619
149B:B:L284 3.2725405
150B:B:L285 3.464516
151B:B:Y289 7.61571717
152B:B:D290 8.4275416
153B:B:D291 6.77418
154B:B:N293 7.0375415
155B:B:N295 6.79833616
156B:B:W297 5.096518
157B:B:L300 3.98667616
158B:B:K301 5.758505
159B:B:G306 1.7825404
160B:B:V307 4.68413
161B:B:H311 7.834519
162B:B:R314 11.065418
163B:B:L318 3.4675416
164B:B:M325 6.02415
165B:B:W332 10.6486719
166B:B:D333 6.92519
167B:B:L336 4.75333617
168B:B:K337 6.4675416
169B:B:W339 7.86619
170G:G:Y40 7.7675416
171G:G:D48 6.076519
172G:G:L50 3.6075419
173G:G:L51 3.878516
174G:G:N59 5.0175409
175G:G:P60 7.1125419
176G:G:F61 4.66818
177R:R:F9 5.2525407
178R:R:V16 3.69406
179R:R:Y19 6.258505
180R:R:W26 5.35675
181R:R:V30 4.6375476
182R:R:T41 5.02254149
183R:R:Q48 2.60833607
184R:R:L51 3.51409
185R:R:F55 3.28857728
186R:R:L58 3.962528
187R:R:N61 6.826529
188R:R:L62 5.10833629
189R:R:Q74 7.52333678
190R:R:Y81 4.99505
191R:R:W86 7.142588
192R:R:F96 5.04571786
193R:R:F101 7.465407
194R:R:I114 4.035629
195R:R:R118 6.06833629
196R:R:Y119 7.296529
197R:R:L120 3.808525
198R:R:F128 6.51833628
199R:R:F132 5.70167627
200R:R:T144 2.8125427
201R:R:W145 6.0375429
202R:R:F152 7.6165128
203R:R:W156 9.954156
204R:R:Y159 8.235405
205R:R:V162 3.795423
206R:R:T167 3.9825404
207R:R:C168 5.41489
208R:R:R172 7.69625
209R:R:R176 7.335494
210R:R:Y186 7.354128
211R:R:F187 3.7545168
212R:R:F197 7.19407
213R:R:Y198 6.825629
214R:R:Y332 6.99286728
215R:R:I333 3.1465167
216R:R:F335 5.334528
217R:R:L338 5.3025425
218R:R:N339 9427
219R:R:H352 7.348524
220R:R:N357 7.985478
221R:R:W360 9.19778
222R:R:N362 8.28529
223R:R:C364 3.92476
224R:R:L369 3.134529
225R:R:Y370 4.16829
226R:R:F377 5.646149
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D333 B:B:N313 12.3984.04YesNo097
2B:B:N313 B:B:W332 13.00435.65NoYes079
3A:A:F259 A:A:W258 26.75373.01YesYes195
4A:A:F259 A:A:I221 13.09568.79YesYes198
5A:A:I221 A:A:L39 11.95462.85YesYes189
6A:A:G40 A:A:L39 98.31881.71NoYes099
7A:A:G40 A:A:S44 98.23351.86NoYes099
8A:A:C224 A:A:S44 1001.72YesYes079
9A:A:C224 A:A:F267 97.76822.79YesYes079
10A:A:F267 A:A:F334 93.32594.29YesYes393
11A:A:F334 A:A:Y320 93.72093.09YesYes337
12A:A:V342 A:A:Y320 93.49385.05NoYes377
13A:A:N346 A:A:V342 93.42382.96NoNo047
14A:A:K349 A:A:N346 93.22662.8NoNo054
15A:A:F354 A:A:K349 93.00098.69NoNo255
16A:A:F354 A:A:L348 92.93039.74NoYes259
17A:A:L348 A:A:L353 90.49765.54YesYes297
18A:A:F259 A:A:I253 13.08932.51YesYes198
19A:A:I253 A:A:L39 11.86734.28YesYes189
20A:A:L353 R:R:R118 83.89857.29YesYes279
21A:A:F215 A:A:L37 85.829410.96YesYes199
22A:A:I221 A:A:L37 10.70242.85YesYes189
23A:A:I221 A:A:I264 12.61912.94YesNo186
24A:A:F250 A:A:I264 11.01276.28YesNo196
25B:B:L190 B:B:S160 14.93174.5YesNo056
26B:B:S147 B:B:S160 15.55544.89NoNo096
27B:B:S147 B:B:Y145 15.86372.54NoYes098
28A:A:Q204 B:B:Y145 42.1717.89YesYes198
29A:A:Q204 B:B:L117 26.03352.66YesYes199
30B:B:M101 B:B:Y145 21.38657.18NoYes098
31B:B:L117 B:B:M101 21.55032.83YesNo099
32A:A:Q204 A:A:W211 23.39964.38YesYes199
33A:A:S206 B:B:Y145 19.54915.09YesYes188
34A:A:S206 A:A:W211 29.87852.47YesYes189
35A:A:K210 B:B:Y145 71.93483.58YesYes198
36A:A:K210 B:B:D228 35.50069.68YesYes199
37A:A:K210 B:B:D246 35.50255.53YesYes199
38R:R:I114 R:R:R118 30.59686.26YesYes299
39R:R:I114 R:R:L62 24.83032.85YesYes299
40R:R:L62 R:R:S107 37.82054.5YesNo299
41R:R:N362 R:R:S107 11.43545.96YesNo299
42R:R:G363 R:R:N362 27.40523.39NoYes099
43R:R:D66 R:R:G363 26.75045.03NoNo099
44R:R:D66 R:R:N38 24.143413.46NoNo099
45R:R:N38 R:R:T63 21.67237.31NoNo099
46R:R:T41 R:R:T63 19.70569.42YesNo099
47R:R:F377 R:R:T41 13.1443.89YesYes1499
48R:R:R118 R:R:Y370 48.066.17YesYes299
49R:R:L62 R:R:Y370 24.91113.52YesYes299
50R:R:L62 R:R:N366 11.69646.87YesNo299
51R:R:N362 R:R:N366 17.160313.62YesNo299
52B:B:I18 B:B:R22 12.49437.52NoNo076
53B:B:D228 B:B:S227 43.58534.42YesNo196
54B:B:D247 B:B:S227 78.28512.94YesNo196
55B:B:D247 B:B:H225 49.67417.56YesYes199
56B:B:F253 B:B:H225 24.54463.39YesYes169
57B:B:F222 B:B:F253 32.53596.43YesYes186
58B:B:D258 B:B:F222 17.91345.97YesYes178
59B:B:D258 B:B:R22 15.010613.1YesNo076
60B:B:D246 B:B:S227 35.24892.94YesNo196
61B:B:D247 B:B:R251 25.8294.76YesYes198
62B:B:F253 B:B:R251 24.5313.21YesYes168
63B:B:H225 B:B:T243 15.858.21YesYes198
64B:B:F241 B:B:V200 10.628610.49YesYes166
65B:B:F241 B:B:F253 15.71658.57YesYes166
66B:B:F234 B:B:V200 13.71587.87YesYes156
67B:B:F241 B:B:L255 10.56232.44YesYes166
68B:B:F234 B:B:L255 13.78352.44YesYes156
69B:B:A193 B:B:F234 18.84496.93NoYes045
70B:B:A193 B:B:D195 14.13383.09NoNo045
71B:B:C271 B:B:D290 18.65729.34NoYes156
72B:B:C271 B:B:Y289 15.36892.69NoYes157
73R:R:S107 R:R:Y332 26.13262.54NoYes298
74R:R:N104 R:R:Y332 11.70736.98NoYes278
75R:R:L100 R:R:N104 11.51092.75NoNo087
76R:R:L369 R:R:Y370 17.56843.52YesYes299
77R:R:C327 R:R:L369 16.84434.76NoYes069
78R:R:C327 R:R:I365 16.46476.55NoNo067
79R:R:T359 R:R:Y332 12.77443.75NoYes288
80R:R:F335 R:R:T359 12.57273.89YesNo288
81A:A:F215 A:A:W211 52.13866.01YesYes199
82A:A:F215 B:B:L117 42.11122.44YesYes199
83A:A:S206 B:B:D186 10.31492.94YesYes189
84B:B:D290 B:B:R314 18.813316.68YesYes168
85A:A:L37 A:A:L39 75.11619.69YesYes199
86A:A:W258 B:B:R314 20.8284YesYes158
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J1A
Class A
SubFamily Orphan
Type A orphans
SubType GPR84
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.24
Date 2023-06-21
D.O.I. 10.1038/s41467-023-38985-6
Net Summary
Imin 2.41
Number of Linked Nodes 849
Number of Links 1160
Number of Hubs 226
Number of Links mediated by Hubs 830
Number of Communities 16
Number of Nodes involved in Communities 339
Number of Links involved in Communities 562
Path Summary
Number Of Nodes in MetaPath 87
Number Of Links MetaPath 86
Number of Shortest Paths 3941042
Length Of Smallest Path 3
Average Path Length 28.9187
Length of Longest Path 52
Minimum Path Strength 1.185
Average Path Strength 5.21514
Maximum Path Strength 22.1
Minimum Path Correlation 0.7
Average Path Correlation 0.988601
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.125
Average % Of Corr. Nodes 37.2654
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 65.769
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8J1A_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLNRM HASMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CSTDTKNVQ FVFDAVTDV IIKNNLKDC GLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J1A_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J1A_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FREK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9NQS5
Sequence
>8J1A_Chain_R
NFSCYHESV LGYRYVAVS WGVVVAVTG TVGNVLTLL ALAIQPKLR 
TRFNLLIAN LTLADLLYC TLLQPFSVD TYLHLHWRT GATFCRVFG 
LLLFASNSV SILTLCLIA LGRYLLIAH PKLFPQVFS AKGIVLALV 
STWVVGVAS FAPLWPIYI LVPVVCTCS FDRIRGRPY TTILMGIYF 
VLGLSSVGI FYCLIHRQV KRAAQALDQ YKLGKVTRM CFAVFLCFA 
LSYIPFLLL NILDARVQA PRVVHMLAA NLTWLNGCI NPVLYAAMN 
RQFRQAYGS ILKRGPRSF HRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G05AOrphanA orphansGPR84Homo sapiens6-OAU-Gi1/&β;1/&γ;232023-11-0110.1038/s41467-023-41201-0
8J18AOrphanA orphansGPR84Homo sapiens(3R)-3-hydroxydodecanoic acid-Gi1/&β;1/&γ;22.892023-06-2110.1038/s41467-023-38985-6
8J19AOrphanA orphansGPR84Homo sapiensPubChem 127045422-Gi1/&β;1/&γ;23.232023-06-2110.1038/s41467-023-38985-6
8J1AAOrphanA orphansGPR84Homo sapiens--Gi1/&β;1/&γ;23.242023-06-2110.1038/s41467-023-38985-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8J1A.zip



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