Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I19 3.925409
2A:A:V34 4.775445
3A:A:L36 4.44447
4A:A:L37 6.62419
5A:A:L38 7.31448
6A:A:L39 4.6325419
7A:A:S44 1.75409
8A:A:K46 4.14549
9A:A:I49 4.1375447
10A:A:M53 5.765448
11A:A:I184 5.0225419
12A:A:F189 7.772549
13A:A:F191 8.3825445
14A:A:F196 6.40833647
15A:A:M198 6.4825447
16A:A:F199 7.28515
17A:A:Q204 4.56833619
18A:A:K210 5.41719
19A:A:W211 6.168519
20A:A:H213 7.1475418
21A:A:C214 3.662517
22A:A:F215 5.32429719
23A:A:I221 4.155618
24A:A:I222 3.575647
25A:A:C224 3.1625407
26A:A:S228 4.02754119
27A:A:Y230 4.7125418
28A:A:R242 5.145409
29A:A:M243 3.856518
30A:A:F250 6.84571719
31A:A:I253 3.375418
32A:A:C254 4.35515
33A:A:W258 6.76167615
34A:A:F259 5.71333619
35A:A:I265 3.3025408
36A:A:L266 4.806519
37A:A:F267 3.84333649
38A:A:L268 5.416518
39A:A:L273 3.9465116
40A:A:F274 5.152509
41A:A:I278 4.506516
42A:A:P282 4.9725415
43A:A:L283 3.698517
44A:A:C286 6.655416
45A:A:Y287 6.17571717
46A:A:Y290 6.584517
47A:A:N294 7.6525413
48A:A:Y296 5.81404
49A:A:E298 3.0125404
50A:A:I303 3.62407
51A:A:F307 4.16833618
52A:A:N311 4.6925418
53A:A:I319 4.0275415
54A:A:Y320 6.05747
55A:A:T321 6.815415
56A:A:F323 5.7875404
57A:A:T324 6.0925449
58A:A:N331 3.652548
59A:A:Q333 6.706545
60A:A:F334 7.03443
61A:A:F336 5.572548
62A:A:V339 5.0825448
63A:A:D341 10.1448
64A:A:L348 6.7375429
65A:A:L353 4.658527
66B:B:D27 5.4375408
67B:B:V40 3.47513
68B:B:M45 4.4375434
69B:B:L51 6.866539
70B:B:H54 7.73667639
71B:B:Y59 9.035418
72B:B:M61 5.1425436
73B:B:W63 6.67167637
74B:B:L69 4.245405
75B:B:L70 6.048535
76B:B:V71 4.6075468
77B:B:D76 5.534539
78B:B:K78 5.136538
79B:B:L79 4.43467
80B:B:I80 6.695638
81B:B:I81 4.13833667
82B:B:W82 9.59286739
83B:B:S84 4.105435
84B:B:K89 7.24167639
85B:B:I93 4.032567
86B:B:L95 4.81568
87B:B:W99 6.575819
88B:B:Y105 4.82143766
89B:B:N110 7.23754124
90B:B:Y111 7.27754124
91B:B:C114 4.228568
92B:B:L117 3.264519
93B:B:N119 3.38409
94B:B:C121 3.34478
95B:B:I123 3.804506
96B:B:Y124 4.26286766
97B:B:L126 4.185465
98B:B:E130 3.78754143
99B:B:V133 5.3575464
100B:B:E138 3.3275466
101B:B:L139 4.825609
102B:B:H142 6.15429779
103B:B:Y145 5.80125818
104B:B:L146 4.73477
105B:B:F151 5.35667609
106B:B:L152 4.59403
107B:B:D154 6.52254126
108B:B:I157 5.1975407
109B:B:T159 4.256579
110B:B:D163 7.858579
111B:B:W169 9.97578
112B:B:D170 6.8475459
113B:B:F180 8.42557
114B:B:H183 6.66571759
115B:B:D186 4.57667619
116B:B:L190 5.235455
117B:B:F199 6.99333659
118B:B:V200 5.826516
119B:B:C204 5.026517
120B:B:D205 5.98559
121B:B:K209 7.676556
122B:B:L210 4.755415
123B:B:W211 10.5683658
124B:B:Q220 6.558517
125B:B:F222 6.584518
126B:B:H225 8.8525819
127B:B:D228 7.245419
128B:B:I229 5.5175417
129B:B:I232 4.06286718
130B:B:F234 5.75515
131B:B:F235 5.73714716
132B:B:P236 6.725417
133B:B:F241 6.91616
134B:B:T243 5.238518
135B:B:D246 6.145419
136B:B:D247 7.21667619
137B:B:T249 6.488516
138B:B:R251 10.6333618
139B:B:F253 6.625616
140B:B:D258 9.25417
141B:B:M262 4.8375414
142B:B:Y264 4.48167615
143B:B:I269 3.672514
144B:B:S277 3.695435
145B:B:F278 5.535417
146B:B:R283 7.454519
147B:B:L284 3.2725405
148B:B:L285 3.464516
149B:B:Y289 7.61571717
150B:B:D290 8.4275416
151B:B:D291 6.77418
152B:B:N293 7.0375415
153B:B:N295 6.79833616
154B:B:W297 5.096518
155B:B:L300 3.98667616
156B:B:K301 5.758505
157B:B:G306 1.7825404
158B:B:V307 4.68413
159B:B:H311 7.834539
160B:B:R314 11.065418
161B:B:L318 3.4675436
162B:B:M325 6.02435
163B:B:W332 10.6486719
164B:B:D333 6.92539
165B:B:L336 4.75333637
166B:B:K337 6.4675436
167B:B:W339 7.86639
168G:G:Y40 7.7675416
169G:G:D48 6.076539
170G:G:L50 3.6075439
171G:G:L51 4.24406
172G:G:N59 5.0175409
173G:G:P60 7.1125439
174G:G:F61 4.98738
175R:R:F9 5.2525407
176R:R:V16 3.69406
177R:R:Y19 6.258505
178R:R:W26 5.35685
179R:R:T41 5.02254159
180R:R:Q48 2.60833607
181R:R:L51 3.51409
182R:R:F55 3.628528
183R:R:L58 4.3425428
184R:R:N61 6.826529
185R:R:L62 5.10833629
186R:R:Q74 7.52333688
187R:R:Y81 4.99505
188R:R:W86 7.142598
189R:R:F96 5.48696
190R:R:F101 7.465407
191R:R:I114 4.035629
192R:R:R118 6.06833629
193R:R:Y119 7.296529
194R:R:F128 7.334528
195R:R:F132 7.3325427
196R:R:F152 7.6165138
197R:R:W156 9.954166
198R:R:Y159 8.235405
199R:R:V162 3.795423
200R:R:T167 3.9825404
201R:R:C168 5.41499
202R:R:R172 7.69625
203R:R:R176 7.3354104
204R:R:Y186 7.354138
205R:R:F187 4.0825408
206R:R:F197 7.19407
207R:R:Y198 6.825629
208R:R:Y332 6.99286728
209R:R:I333 3.146507
210R:R:F335 6.0575428
211R:R:L338 5.3025425
212R:R:N339 9427
213R:R:H352 7.348524
214R:R:N357 7.985488
215R:R:W360 10.3133688
216R:R:N362 8.28529
217R:R:C364 3.92486
218R:R:L369 3.134529
219R:R:Y370 4.40857729
220R:R:F377 5.646159
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:G330 B:B:S331 13.17633.71NoNo359
2B:B:D333 B:B:S331 12.763210.31YesNo399
3B:B:D333 B:B:N313 26.27854.04YesNo097
4B:B:N313 B:B:W332 27.13045.65NoYes079
5A:A:W258 B:B:W332 17.67733.75YesYes159
6A:A:F259 A:A:W258 60.2713.01YesYes195
7A:A:F259 A:A:I221 29.61088.79YesYes198
8A:A:I221 A:A:L39 27.11552.85YesYes189
9A:A:G40 A:A:L39 94.97571.71NoYes099
10A:A:G40 A:A:S44 94.93991.86NoYes099
11A:A:C224 A:A:S44 1001.72YesYes079
12A:A:C224 A:A:F267 98.07862.79YesYes079
13A:A:F267 A:A:F334 95.8874.29YesYes493
14A:A:F334 A:A:Y320 97.67143.09YesYes437
15A:A:V342 A:A:Y320 98.82945.05NoYes477
16A:A:N346 A:A:V342 98.83312.96NoNo047
17A:A:K349 A:A:N346 98.70482.8NoNo054
18A:A:F354 A:A:K349 98.50878.69NoNo255
19A:A:F354 A:A:L348 98.5119.74NoYes259
20A:A:L348 A:A:L353 95.86985.54YesYes297
21A:A:F259 A:A:I253 29.4182.51YesYes198
22A:A:I253 A:A:L39 26.4364.28YesYes189
23A:A:L353 R:R:R118 92.5067.29YesYes279
24A:A:C214 A:A:H213 14.17332.95YesYes178
25B:B:W332 B:B:Y59 14.21419.65YesYes198
26A:A:C214 B:B:W99 14.08432.61YesYes179
27A:A:F215 A:A:L37 47.561110.96YesYes199
28A:A:I221 A:A:I264 10.88832.94YesNo186
29B:B:L190 B:B:S160 10.92084.5YesNo056
30B:B:S147 B:B:S160 13.51344.89NoNo096
31B:B:S147 B:B:Y145 13.82182.54NoYes098
32A:A:Q204 B:B:Y145 52.73267.89YesYes198
33A:A:Q204 B:B:N119 14.91065.28YesYes099
34B:B:D163 B:B:H142 12.78073.78YesYes799
35B:B:D163 B:B:G144 13.77425.03YesNo098
36B:B:G144 B:B:N119 14.03753.39NoYes089
37B:B:L117 B:B:W99 19.45024.56YesYes199
38A:A:Q204 B:B:L117 11.68282.66YesYes199
39A:A:F215 A:A:W211 54.0126.01YesYes199
40A:A:Q204 A:A:W211 55.57364.38YesYes199
41A:A:K210 B:B:Y145 45.45333.58YesYes198
42A:A:K210 B:B:D228 22.10519.68YesYes199
43A:A:K210 B:B:D246 22.10955.53YesYes199
44B:B:L318 B:B:S275 15.0013YesNo068
45B:B:S275 B:B:T274 15.48644.8NoNo088
46B:B:R314 B:B:T274 15.31272.59YesNo188
47B:B:R314 B:B:W332 12.715920.99YesYes189
48R:R:I114 R:R:R118 33.51926.26YesYes299
49R:R:I114 R:R:L62 22.47372.85YesYes299
50R:R:L62 R:R:S107 31.81284.5YesNo299
51R:R:N362 R:R:S107 12.93745.96YesNo299
52R:R:G363 R:R:N362 31.18413.39NoYes099
53R:R:D66 R:R:G363 30.48515.03NoNo099
54R:R:D66 R:R:N38 27.739913.46NoNo099
55R:R:N38 R:R:T63 23.20777.31NoNo099
56R:R:T41 R:R:T63 21.1069.42YesNo099
57R:R:F377 R:R:T41 14.08683.89YesYes1599
58R:R:R118 R:R:Y370 57.14116.17YesYes299
59R:R:L62 R:R:Y370 22.78863.52YesYes299
60R:R:L62 R:R:N366 13.21996.87YesNo299
61R:R:N362 R:R:N366 19.429713.62YesNo299
62B:B:D228 B:B:S227 22.37594.42YesNo196
63B:B:D247 B:B:S227 43.7722.94YesNo196
64B:B:D247 B:B:H225 28.65097.56YesYes199
65B:B:F253 B:B:H225 12.12893.39YesYes169
66B:B:F222 B:B:F253 16.8916.43YesYes186
67B:B:D258 B:B:F222 11.62935.97YesYes178
68B:B:D258 B:B:R22 10.150413.1YesNo076
69B:B:D246 B:B:S227 21.83582.94YesNo196
70B:B:D247 B:B:R251 13.01324.76YesYes198
71B:B:F253 B:B:R251 12.09653.21YesYes168
72B:B:C271 B:B:D290 43.1979.34NoYes156
73B:B:C271 B:B:Y289 36.1082.69NoYes157
74B:B:W297 B:B:Y289 17.21448.68YesYes187
75B:B:W297 B:B:Y264 16.93584.82YesYes185
76B:B:F234 B:B:V200 10.49257.87YesYes156
77B:B:A287 B:B:Y289 11.38064NoYes167
78B:B:A287 B:B:V276 11.04843.39NoNo066
79R:R:L369 R:R:Y370 29.1653.52YesYes299
80R:R:C327 R:R:L369 28.66714.76NoYes069
81R:R:C327 R:R:I365 28.26416.55NoNo067
82R:R:I365 R:R:L361 14.19688.56NoNo075
83R:R:L361 R:R:W26 11.97573.42NoYes055
84R:R:N357 R:R:W26 14.43375.65YesYes885
85R:R:C364 R:R:I365 13.94813.27YesNo067
86R:R:C364 R:R:W26 11.80683.92YesYes865
87R:R:S107 R:R:Y332 18.60432.54NoYes298
88R:R:T359 R:R:Y332 11.95853.75NoYes288
89R:R:F335 R:R:T359 11.68553.89YesNo288
90B:B:L285 B:B:V276 10.4212.98YesNo066
91B:B:L285 B:B:Y264 10.78283.52YesYes165
92B:B:D290 B:B:R314 43.261316.68YesYes168
93A:A:L37 A:A:L39 41.76619.69YesYes199
94A:A:W258 B:B:R314 46.35354YesYes158
95B:B:D333 B:B:H311 11.05156.3YesYes399
96B:B:F278 B:B:L285 14.33026.09YesYes176
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8J1A
Class A
SubFamily Orphan
Type Orphan
SubType GPR84
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 3.24
Date 2023-06-21
D.O.I. 10.1038/s41467-023-38985-6
Net Summary
Imin 2.48
Number of Linked Nodes 849
Number of Links 1137
Number of Hubs 220
Number of Links mediated by Hubs 801
Number of Communities 16
Number of Nodes involved in Communities 326
Number of Links involved in Communities 529
Path Summary
Number Of Nodes in MetaPath 97
Number Of Links MetaPath 96
Number of Shortest Paths 2061021
Length Of Smallest Path 3
Average Path Length 26.4391
Length of Longest Path 52
Minimum Path Strength 1.185
Average Path Strength 5.36498
Maximum Path Strength 22.1
Minimum Path Correlation 0.7
Average Path Correlation 0.985161
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.0303
Average % Of Corr. Nodes 43.7588
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 63.4052
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• D2 dopamine receptor binding   • protein binding   • binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • magnesium ion binding   • metal ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • cell communication   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • response to hormone   • response to chemical   • response to endogenous stimulus   • response to peptide hormone   • response to oxygen-containing compound   • response to nitrogen compound   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • response to prostaglandin E   • cellular response to forskolin   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to alcohol   • response to forskolin   • cellular response to lipid   • cellular response to ketone   • midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle
Gene OntologyCellular Component• midbody   • cellular anatomical structure   • membrane-bounded organelle   • intracellular anatomical structure   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • intracellular membrane-bounded organelle   • nucleolus   • intracellular organelle lumen   • intracellular organelle   • organelle lumen   • organelle   • membraneless organelle   • nuclear lumen   • cell periphery   • cell cortex   • cytoplasm   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • cytosol   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • organelle membrane   • lysosome   • Golgi apparatus   • endomembrane system   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • urotensin II receptor activity   • peptide receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • G protein-coupled peptide receptor activity   • signaling receptor activity   • transmembrane signaling receptor activity   • neuropeptide signaling pathway   • receptor complex   • tertiary granule membrane   • intracellular vesicle   • tertiary granule   • cytoplasmic vesicle membrane   • vesicle membrane   • cytoplasmic vesicle   • secretory granule   • secretory vesicle   • secretory granule membrane   • specific granule membrane   • specific granule
SCOP2Domain Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Ras-like P-loop GTPases   • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8J1A_Chain_A
TLSAEDKAA VERSKMIDR NLREDGEKA AREVKLLLL GAGESGKNT 
IVKQMKITG IVETHFTFK DLHFKMFDV GAQRSERKK WIHCFEGVT 
AIIFCVALS DYDLVLNRM HASMKLFDS ICNNKWFTD TSIILFLNK 
KDLFEEKIK KSPLTICYP EYAGSNTYE EAAAYIQCQ FEDLNKRKD 
TKEIYTHFT CSTDTKNVQ FVFDAVTDV IIKNNLKDC GLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8J1A_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8J1A_Chain_G
ASIAQARKL VEQLKMEAN IDRIKVSKA AADLMAYCE AHAKEDPLL 
TPVPASENP FREK


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9NQS5
Sequence
>8J1A_Chain_R
NFSCYHESV LGYRYVAVS WGVVVAVTG TVGNVLTLL ALAIQPKLR 
TRFNLLIAN LTLADLLYC TLLQPFSVD TYLHLHWRT GATFCRVFG 
LLLFASNSV SILTLCLIA LGRYLLIAH PKLFPQVFS AKGIVLALV 
STWVVGVAS FAPLWPIYI LVPVVCTCS FDRIRGRPY TTILMGIYF 
VLGLSSVGI FYCLIHRQV KRAAQALDQ YKLGKVTRM CFAVFLCFA 
LSYIPFLLL NILDARVQA PRVVHMLAA NLTWLNGCI NPVLYAAMN 
RQFRQAYGS ILKRGPRSF HRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8G05AOrphanOrphanGPR84Homo sapiens6-OAU-Gi1/β1/γ232023-11-0110.1038/s41467-023-41201-0
8G05 (No Gprot) AOrphanOrphanGPR84Homo sapiens6-OAU-32023-11-0110.1038/s41467-023-41201-0
8J1AAOrphanOrphanGPR84Homo sapiens--Gi1/β1/γ23.242023-06-2110.1038/s41467-023-38985-6
8J1A (No Gprot) AOrphanOrphanGPR84Homo sapiens--3.242023-06-2110.1038/s41467-023-38985-6
8J19AOrphanOrphanGPR84Homo sapiensLY237-Gi1/β1/γ23.232023-06-2110.1038/s41467-023-38985-6
8J19 (No Gprot) AOrphanOrphanGPR84Homo sapiensLY237-3.232023-06-2110.1038/s41467-023-38985-6
8J18AOrphanOrphanGPR84Homo sapiens(3R)-3-Hydroxydodecanoic acid-Gi1/β1/γ22.892023-06-2110.1038/s41467-023-38985-6
8J18 (No Gprot) AOrphanOrphanGPR84Homo sapiens(3R)-3-Hydroxydodecanoic acid-2.892023-06-2110.1038/s41467-023-38985-6




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