Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L38 5.0075458
2A:A:M53 5.796558
3A:A:I184 9.32419
4A:A:F191 6.5455
5A:A:F196 5.744557
6A:A:M198 3.80167657
7A:A:F199 15.782515
8A:A:D200 4.475459
9A:A:V201 4.574519
10A:A:K210 7.23579
11A:A:H213 6.045418
12A:A:F215 8.682519
13A:A:I221 5.14418
14A:A:D229 3.55754168
15A:A:Y230 5.61254128
16A:A:F250 2.9725409
17A:A:F259 7.302519
18A:A:F267 5.1054179
19A:A:N269 4.8409
20A:A:L273 2.805406
21A:A:F274 3.5625129
22A:A:I278 6.054126
23A:A:C286 4.9445126
24A:A:Y287 3.756676127
25A:A:Y290 10.2125407
26A:A:Y296 6.6875404
27A:A:F307 3.61408
28A:A:R313 7.174514
29A:A:Y320 4.455407
30A:A:N331 6.144178
31A:A:L353 4.192507
32B:B:L30 4.37405
33B:B:V40 3.0675403
34B:B:M45 3.77514
35B:B:R48 8.185417
36B:B:L51 5.29469
37B:B:H54 8.31333669
38B:B:Y59 11.275418
39B:B:W63 6.826507
40B:B:V71 4.4275418
41B:B:S74 7.245469
42B:B:Q75 6.648519
43B:B:D76 5.904569
44B:B:L79 3.315417
45B:B:I81 3.054517
46B:B:W82 8.91667669
47B:B:D83 7.34418
48B:B:N88 5.0425417
49B:B:K89 5.214569
50B:B:I93 3.62407
51B:B:L95 3.788518
52B:B:W99 7.7671019
53B:B:V100 3.895419
54B:B:Y105 4.54375816
55B:B:N110 5.155494
56B:B:Y111 6.568594
57B:B:C114 3.2518
58B:B:L117 4.3925419
59B:B:I123 3.024596
60B:B:Y124 4.504516
61B:B:L126 3.7875415
62B:B:T128 2.945403
63B:B:H142 6.881437109
64B:B:Y145 6.63571778
65B:B:F151 4.005699
66B:B:L152 3.442523
67B:B:Q156 3.72167625
68B:B:D163 8.6865109
69B:B:W169 10.0525108
70B:B:D170 8.156529
71B:B:T177 4.79424
72B:B:F180 6.242527
73B:B:H183 7.832529
74B:B:V187 4.3429
75B:B:L190 5.6175425
76B:B:F199 6.94529
77B:B:V200 4.245436
78B:B:C204 5.954577
79B:B:D205 6.008529
80B:B:K209 7.11526
81B:B:L210 3.772535
82B:B:W211 7.632528
83B:B:D212 7.3275439
84B:B:R219 4.8475435
85B:B:Q220 7.054537
86B:B:H225 7.8639
87B:B:D228 7.468579
88B:B:I232 5.09438
89B:B:F234 4.06167635
90B:B:F235 5.2256206
91B:B:F241 5.31667636
92B:B:T243 5.126538
93B:B:D247 5.01409
94B:B:T249 5.1175436
95B:B:R251 11.74438
96B:B:R256 7.748509
97B:B:A257 3.6525407
98B:B:D258 8.078537
99B:B:Y264 4.538505
100B:B:H266 5.305484
101B:B:F278 5.225207
102B:B:L284 3.225405
103B:B:Y289 9.51333687
104B:B:D290 7.1025406
105B:B:W297 7.13488
106B:B:L300 3.8775406
107B:B:K301 5.716505
108B:B:L308 5.385417
109B:B:H311 11.1625419
110B:B:N313 3.7725417
111B:B:L318 3.9854216
112B:B:T321 5.9425417
113B:B:D323 7.4475417
114B:B:M325 5.18415
115B:B:T329 4.705408
116B:B:W332 9.35167619
117B:B:D333 8.446519
118B:B:L336 4.5775467
119B:B:K337 7.044516
120B:B:W339 6.95667619
121G:G:V16 4.05754197
122G:G:K29 5.0225404
123G:G:D48 6.694519
124G:G:P49 3.458517
125G:G:L50 3.5825419
126G:G:N59 5.785419
127G:G:P60 7.1725419
128G:G:F61 5.18875818
129R:R:F38 6.214222
130R:R:Y49 4.0575408
131R:R:N60 6.42254119
132R:R:T63 3.09754248
133R:R:Q70 7.98254144
134R:R:V71 3.14405
135R:R:N75 2.7554147
136R:R:Y80 5.4407
137R:R:L82 3.29405
138R:R:E88 6.0985119
139R:R:P96 4.0525409
140R:R:W98 5.41167606
141R:R:W108 6.935139
142R:R:L112 4.9385133
143R:R:Y120 6.65254255
144R:R:F123 5.0625405
145R:R:I130 4.615447
146R:R:F132 4.148336157
147R:R:R154 7.6407
148R:R:I162 2.6825404
149R:R:H174 9.33754256
150R:R:T185 5.9545133
151R:R:C186 6.114139
152R:R:F187 5.725134
153R:R:Y200 6.4475445
154R:R:Y201 4.934544
155R:R:F204 6.168545
156R:R:F208 5.09857748
157R:R:I215 4.64448
158R:R:N219 4.42449
159R:R:Q236 9.385405
160R:R:F251 4.49549
161R:R:Y258 5.47447
162R:R:L262 7.84446
163R:R:K265 4.442545
164R:R:F269 4.066504
165R:R:Y287 4.906504
166R:R:F293 4.6275407
167R:R:N300 74119
168R:R:V302 2.684117
169R:R:E318 8.375144
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q75 B:B:V100 20.1914.3YesYes199
2B:B:Q75 B:B:W99 59.54835.48YesYes199
3A:A:F215 B:B:W99 70.268610.02YesYes199
4A:A:F215 A:A:L37 1007.31YesNo199
5A:A:I221 A:A:L37 99.374.28YesNo189
6A:A:I221 A:A:I264 97.61515.89YesNo086
7A:A:F250 A:A:I264 96.24022.51YesNo096
8A:A:F250 A:A:F307 93.82883.22YesYes098
9A:A:F307 A:A:M243 89.05152.49YesNo088
10A:A:C286 A:A:M243 88.90783.24YesNo068
11A:A:C286 A:A:Y230 88.38345.38YesYes1268
12A:A:F274 A:A:Y230 87.21166.19YesYes1298
13A:A:F274 A:A:L227 83.45052.44YesNo097
14A:A:L227 A:A:L268 83.295811.07NoNo078
15A:A:L268 A:A:T324 82.98592.95NoNo089
16A:A:F267 A:A:T324 81.830211.67YesNo1799
17A:A:F267 A:A:I265 81.58052.51YesNo098
18A:A:I265 A:A:Y320 81.42323.63NoYes087
19A:A:S263 A:A:Y320 10.98152.54NoYes077
20A:A:A220 A:A:S263 10.27961.71NoNo087
21A:A:A220 A:A:L36 10.04683.15NoNo087
22A:A:F215 A:A:V201 15.81392.62YesYes199
23B:B:L117 B:B:W99 18.28156.83YesYes199
24A:A:Q204 A:A:V201 15.58952.87NoYes199
25A:A:Q204 A:A:S206 15.44467.22NoNo098
26B:B:L117 B:B:M101 33.25834.24YesNo099
27B:B:M101 B:B:Y145 33.08765.99NoYes098
28A:A:S206 B:B:Y145 15.30785.09NoYes088
29A:A:K210 B:B:Y145 24.98757.17YesYes798
30A:A:K210 B:B:D228 24.29858.3YesYes799
31B:B:Q75 B:B:Y59 23.843314.65YesYes198
32A:A:E318 A:A:Y320 71.96328.98NoYes047
33A:A:E318 A:A:K345 71.79528.1NoNo045
34A:A:K345 R:R:L232 71.62737.05NoNo052
35R:R:T63 R:R:V309 10.15793.17YesNo2486
36R:R:P305 R:R:T63 11.32355.25NoYes098
37R:R:N60 R:R:P305 11.55414.89YesNo099
38R:R:E88 R:R:N60 13.132210.52YesYes1199
39R:R:E88 R:R:N125 18.79212.63YesNo1199
40R:R:I126 R:R:N125 24.47832.83NoNo079
41R:R:F208 R:R:I126 24.52382.51YesNo087
42R:R:F208 R:R:I130 60.7483.77YesYes487
43R:R:F251 R:R:I130 61.62112.51YesYes497
44R:R:F251 R:R:I215 63.01083.77YesYes498
45R:R:I215 R:R:N219 63.92257.08YesYes489
46R:R:A244 R:R:N219 64.88774.69NoYes069
47R:R:A244 R:R:S243 67.93571.71NoNo067
48A:A:L353 R:R:S243 68.10523YesNo077
49A:A:L353 R:R:V240 69.68555.96YesNo077
50R:R:I226 R:R:V240 69.85213.07NoNo087
51R:R:I226 R:R:L232 70.01964.28NoNo082
52B:B:C218 G:G:Q18 11.5127.63NoNo059
53G:G:L19 G:G:Q18 10.5962.66NoNo099
54B:B:L14 G:G:L19 10.13778.3NoNo089
55B:B:F241 B:B:T243 14.51532.59YesYes368
56B:B:I43 B:B:M45 14.12862.92NoYes034
57B:B:I43 B:B:V40 13.54063.07NoYes033
58B:B:D298 B:B:V40 11.27294.38NoYes093
59B:B:M45 B:B:W339 21.12074.65YesYes149
60B:B:K337 B:B:W339 12.43248.12YesYes169
61B:B:N313 B:B:W332 30.78195.65YesYes179
62B:B:D333 B:B:N313 15.63154.04YesYes197
63B:B:K57 B:B:Q75 23.39572.71NoYes199
64B:B:S147 B:B:Y145 27.8932.54NoYes098
65B:B:L190 B:B:S160 16.61759.01YesNo056
66B:B:S160 B:B:V187 12.3064.85NoYes069
67B:B:D228 B:B:S227 23.70215.89YesNo796
68B:B:D247 B:B:S227 23.53497.36YesNo096
69B:B:D247 B:B:S245 10.97425.89YesNo099
70B:B:H225 B:B:S245 10.79879.76YesNo099
71B:B:D247 B:B:T249 12.17572.89YesYes096
72B:B:H225 B:B:T249 10.82642.74YesYes396
73B:B:H225 B:B:T243 19.814410.95YesYes398
74B:B:T329 B:B:W339 12.46238.49YesYes089
75B:B:H311 B:B:T329 15.13532.74YesYes098
76B:B:H311 B:B:K337 13.680613.1YesYes196
77B:B:N313 B:B:S331 14.77362.98YesNo179
78R:R:K265 R:R:L262 14.46922.82YesYes456
79R:R:K265 R:R:L190 14.47274.23YesNo054
80R:R:D188 R:R:L190 11.82012.71NoNo054
81R:R:D188 R:R:F187 11.144410.75NoYes054
82R:R:F208 R:R:Y258 15.09046.19YesYes487
83R:R:F208 R:R:Y127 13.30475.16YesNo088
84B:B:S147 B:B:S160 27.68854.89NoNo096
85B:B:K57 B:B:W332 23.326712.76NoYes199
86B:B:W332 B:B:Y59 23.326114.47YesYes198
87B:B:D333 B:B:H311 14.643817.65YesYes199
88B:B:H311 B:B:S331 14.576811.16YesNo199
89A:A:F199 A:A:F215 15.212818.22YesYes159
90A:A:F199 B:B:L117 15.12923.65YesYes159
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HQE
Class A
SubFamily Orphan
Type Orphan
SubType GPR132
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.97
Date 2023-10-11
D.O.I. 0.1038/s42255-023-00899-4
Net Summary
Imin 2.46
Number of Linked Nodes 848
Number of Links 1030
Number of Hubs 169
Number of Links mediated by Hubs 633
Number of Communities 25
Number of Nodes involved in Communities 247
Number of Links involved in Communities 352
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 1299886
Length Of Smallest Path 3
Average Path Length 33.9629
Length of Longest Path 73
Minimum Path Strength 1.175
Average Path Strength 5.66924
Maximum Path Strength 28.285
Minimum Path Correlation 0.7
Average Path Correlation 0.987167
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 44.622
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 52.9161
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • mitotic cell cycle process   • cell cycle phase transition   • cell cycle   • G1/S transition of mitotic cell cycle   • cell cycle G1/S phase transition   • mitotic cell cycle   • mitotic cell cycle phase transition   • cell cycle process   • regulation of cell cycle phase transition   • G2/M transition of mitotic cell cycle   • negative regulation of biological process   • negative regulation of cell cycle   • negative regulation of mitotic cell cycle   • regulation of mitotic cell cycle   • negative regulation of cellular process   • negative regulation of cell cycle phase transition   • regulation of cell cycle   • cell cycle G2/M phase transition   • negative regulation of mitotic cell cycle phase transition   • regulation of G2/M transition of mitotic cell cycle   • regulation of cell cycle process   • regulation of cell cycle G2/M phase transition   • negative regulation of cell cycle process   • regulation of mitotic cell cycle phase transition   • negative regulation of cell cycle G2/M phase transition   • negative regulation of G2/M transition of mitotic cell cycle   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • periplasmic space   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • cellular component organization   • cellular component organization or biogenesis   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HQE_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKILT ICYPEYAGS NTYEEAAAY IQCQFEDLN KRKDTKEIY 
THFTCSTDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HQE_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HQE_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9UNW8
Sequence
>8HQE_Chain_R
SFEESRIVL VVVYSAVCT LGVPANCLT AWLALLQVL QGNVLAVYL 
LCLALCELL YTGTLPLWV IYIRNQHRW TLGLLACKV TAYIFFCNI 
YVSILFLCC ISCDRFVAV VYALESRGR RRRRTAILI SACIFILVG 
IVHYPVFQT EDKETCFDM LQMDSRIAG YYYARFTVG FAIPLSIIA 
FTNHRIFRS IKQSMGLSA AQKAKVKHS AIAVVVIFL VCFAPYHLV 
LLVKAAAFS YYRGAMCGL EERLYTASV VFLCLSTVN GVADPIIYV 
LATDHSRQE VSRIHKGWK EWSMKTDVT RLTHSRDTE E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HVIAOrphanOrphanGPR132Homo sapiensNOX-6-7-Gi1/β1/γ23.042023-10-110.1038/s42255-023-00899-4
8HVI (No Gprot) AOrphanOrphanGPR132Homo sapiensNOX-6-7-3.042023-10-110.1038/s42255-023-00899-4
8HQNAOrphanOrphanGPR132Homo sapiens9-S-HODE-Gi1/β1/γ232023-10-110.1038/s42255-023-00899-4
8HQN (No Gprot) AOrphanOrphanGPR132Homo sapiens9-S-HODE-32023-10-110.1038/s42255-023-00899-4
8HQMAOrphanOrphanGPR132Homo sapiensNPGLY-Gi1/β1/γ22.952023-10-110.1038/s42255-023-00899-4
8HQM (No Gprot) AOrphanOrphanGPR132Homo sapiensNPGLY-2.952023-10-110.1038/s42255-023-00899-4
8HQEAOrphanOrphanGPR132Homo sapiens--Gi1/β1/γ22.972023-10-110.1038/s42255-023-00899-4
8HQE (No Gprot) AOrphanOrphanGPR132Homo sapiens--2.972023-10-110.1038/s42255-023-00899-4




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