Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1B:B:L30 4.37405
2B:B:V40 3.0675403
3B:B:M45 3.77514
4B:B:R48 8.185417
5B:B:L51 5.29419
6B:B:H54 8.31333619
7B:B:Y59 11.275418
8B:B:W63 6.85167617
9B:B:V71 4.4275418
10B:B:S74 7.245419
11B:B:Q75 6.648519
12B:B:D76 5.904519
13B:B:L79 3.315417
14B:B:I81 3.054517
15B:B:W82 8.91667619
16B:B:D83 7.34418
17B:B:N88 5.0425417
18B:B:K89 5.214519
19B:B:I93 3.62407
20B:B:L95 3.788518
21B:B:W99 6.2641019
22B:B:V100 3.895419
23B:B:Y105 4.54375816
24B:B:N110 5.155484
25B:B:Y111 6.568584
26B:B:C114 3.2518
27B:B:I123 3.024586
28B:B:Y124 4.504516
29B:B:L126 3.7875415
30B:B:T128 2.945403
31B:B:H142 6.88143799
32B:B:Y145 6.63571768
33B:B:F151 4.005689
34B:B:L152 3.442523
35B:B:Q156 3.72167625
36B:B:D163 8.686599
37B:B:W169 10.052598
38B:B:D170 8.156529
39B:B:T177 4.79424
40B:B:F180 6.242527
41B:B:H183 7.832529
42B:B:V187 4.3429
43B:B:L190 5.6175425
44B:B:F199 6.94529
45B:B:V200 4.245436
46B:B:C204 5.954567
47B:B:D205 6.008529
48B:B:K209 7.11526
49B:B:L210 3.772535
50B:B:W211 7.632528
51B:B:D212 7.3275439
52B:B:R219 4.8475435
53B:B:Q220 7.054537
54B:B:H225 7.8639
55B:B:D228 7.468569
56B:B:I232 5.09438
57B:B:F234 4.06167635
58B:B:F235 5.2256166
59B:B:F241 5.31667636
60B:B:T243 5.126538
61B:B:D247 5.01409
62B:B:T249 5.1175436
63B:B:R251 11.74438
64B:B:R256 7.748509
65B:B:A257 3.6525407
66B:B:D258 8.078537
67B:B:Y264 4.538505
68B:B:H266 5.305474
69B:B:F278 5.225167
70B:B:L284 3.225405
71B:B:Y289 9.51333677
72B:B:D290 7.1025406
73B:B:W297 7.13478
74B:B:L300 3.8775406
75B:B:K301 5.716505
76B:B:L308 5.385417
77B:B:H311 11.1625419
78B:B:N313 3.7725417
79B:B:L318 3.9854176
80B:B:T321 5.9425417
81B:B:D323 7.4475417
82B:B:M325 5.18415
83B:B:T329 4.705408
84B:B:W332 9.35167619
85B:B:D333 8.446519
86B:B:L336 4.5775417
87B:B:K337 7.044516
88B:B:W339 6.95667619
89G:G:V16 3.8425157
90G:G:K29 5.0225404
91G:G:D48 6.694519
92G:G:P49 3.458517
93G:G:L50 3.5825419
94G:G:N59 5.785419
95G:G:P60 7.1725419
96G:G:F61 5.18875818
97R:R:F38 6.214182
98R:R:Y49 4.0575408
99R:R:N60 6.42254109
100R:R:T63 3.09754208
101R:R:Q70 7.98254134
102R:R:V71 3.14405
103R:R:N75 2.7554137
104R:R:Y80 5.4407
105R:R:L82 3.29405
106R:R:E88 6.0985109
107R:R:P96 4.0525409
108R:R:W98 5.41167606
109R:R:W108 6.935119
110R:R:L112 4.9385113
111R:R:Y120 6.65254215
112R:R:F123 5.0625405
113R:R:I130 4.615447
114R:R:F132 4.148336147
115R:R:R154 7.6407
116R:R:I162 2.6825404
117R:R:H174 9.33754216
118R:R:T185 5.9545113
119R:R:C186 6.114119
120R:R:F187 5.725114
121R:R:Y200 6.4475445
122R:R:Y201 4.934544
123R:R:F204 6.168545
124R:R:F208 5.09857748
125R:R:I215 4.64448
126R:R:N219 4.42449
127R:R:Q236 9.385405
128R:R:F251 4.49549
129R:R:Y258 5.47447
130R:R:L262 7.84446
131R:R:K265 4.442545
132R:R:F269 4.066504
133R:R:Y287 4.906504
134R:R:F293 4.6275407
135R:R:N300 74109
136R:R:V302 2.684107
137R:R:E318 8.375134
138A:A:L37 6.635419
139A:A:L38 5.0075458
140A:A:M53 5.796558
141A:A:F191 6.5455
142A:A:F196 5.744557
143A:A:M198 3.80167657
144A:A:F199 11.932515
145A:A:D200 4.475459
146A:A:V201 3.524519
147A:A:K210 7.23569
148A:A:H213 6.045418
149A:A:F215 11.682519
150A:A:I221 5.14418
151A:A:D229 3.94754228
152A:A:Y230 5.61254128
153A:A:F250 5.105409
154A:A:I253 2.9725418
155A:A:F259 6.99419
156A:A:F267 5.1054249
157A:A:L268 5.14408
158A:A:N269 4.8409
159A:A:L273 2.805406
160A:A:F274 3.5625129
161A:A:I278 6.054126
162A:A:C286 4.9445126
163A:A:Y287 3.756676127
164A:A:Y290 10.2125407
165A:A:Y296 10.93404
166A:A:F307 3.61408
167A:A:R313 4.0385234
168A:A:Y320 4.455407
169A:A:N331 6.144248
170A:A:L353 4.192507
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:W63 12.11936.98NoYes167
2B:B:C317 B:B:M61 12.76026.48NoNo076
3B:B:C317 B:B:S316 13.14023.44NoNo079
4B:B:S316 B:B:W332 13.34524.94NoYes099
5B:B:F241 B:B:T243 18.65922.59YesYes368
6B:B:F222 B:B:F241 12.14898.57NoYes386
7B:B:D258 B:B:F222 10.83773.58YesNo378
8B:B:D298 B:B:V40 10.61914.38NoYes093
9B:B:I43 B:B:V40 14.03633.07NoYes033
10B:B:I43 B:B:M45 14.67292.92NoYes034
11B:B:M45 B:B:W339 18.86364.65YesYes149
12B:B:N313 B:B:W332 28.92775.65YesYes179
13B:B:N313 B:B:S331 13.86962.98YesNo179
14B:B:H311 B:B:S331 13.68111.16YesNo199
15B:B:H311 B:B:T329 14.14672.74YesYes098
16B:B:T329 B:B:W339 11.59548.49YesYes089
17B:B:D333 B:B:N313 14.6624.04YesYes197
18B:B:D333 B:B:H311 13.719417.65YesYes199
19B:B:H311 B:B:K337 12.871413.1YesYes196
20B:B:K337 B:B:W339 11.57618.12YesYes169
21B:B:K57 B:B:W332 24.201812.76NoYes199
22B:B:K57 B:B:Q75 24.27652.71NoYes199
23B:B:Q75 B:B:V100 21.47064.3YesYes199
24B:B:L95 B:B:V100 10.03634.47YesYes189
25B:B:W332 B:B:Y59 24.201514.47YesYes198
26B:B:Q75 B:B:Y59 24.676214.65YesYes198
27B:B:H225 B:B:T243 22.085810.95YesYes398
28B:B:H225 B:B:S245 11.73589.76YesNo099
29B:B:D247 B:B:S245 11.87115.89YesNo099
30B:B:D247 B:B:S227 24.97957.36YesNo096
31B:B:D228 B:B:S227 25.10465.89YesNo696
32A:A:K210 B:B:D228 25.54568.3YesYes699
33A:A:K210 B:B:Y145 26.05397.17YesYes698
34B:B:S147 B:B:Y145 14.88672.54NoYes098
35B:B:S147 B:B:S160 14.71374.89NoNo096
36B:B:H225 B:B:T249 11.75592.74YesYes396
37B:B:D247 B:B:T249 12.79952.89YesYes096
38B:B:M101 B:B:Y145 20.08155.99NoYes098
39B:B:L117 B:B:M101 20.18284.24NoNo099
40B:B:L117 B:B:W99 20.2736.83NoYes199
41A:A:F199 B:B:W99 41.34369.02YesYes159
42A:A:Q204 A:A:V201 18.89722.87NoYes199
43A:A:Q204 A:A:S206 18.78387.22NoNo098
44A:A:S206 B:B:Y145 18.66455.09NoYes088
45A:A:F215 B:B:W99 41.343610.02YesYes199
46A:A:F199 A:A:L37 50.351112.18YesYes159
47A:A:I221 A:A:L37 1004.28YesYes189
48A:A:I221 A:A:I264 99.05825.89YesNo086
49A:A:F250 A:A:I264 97.4752.51YesNo096
50A:A:F250 A:A:F307 93.23683.22YesYes098
51A:A:F307 A:A:M243 88.44082.49YesNo088
52A:A:C286 A:A:M243 88.27723.24YesNo068
53A:A:C286 A:A:Y230 87.61145.38YesYes1268
54A:A:F274 A:A:Y230 86.36766.19YesYes1298
55A:A:F274 A:A:L227 82.46642.44YesNo097
56A:A:L227 A:A:L268 82.296811.07NoYes078
57A:A:L268 A:A:T324 81.78732.95YesNo089
58A:A:F267 A:A:T324 80.826711.67YesNo2499
59A:A:F267 A:A:I265 80.42282.51YesNo098
60A:A:I265 A:A:Y320 80.25173.63NoYes087
61A:A:E318 A:A:Y320 70.56058.98NoYes047
62A:A:E318 A:A:K345 70.38278.1NoNo045
63A:A:K345 R:R:L232 70.20497.05NoNo052
64R:R:I226 R:R:L232 68.62014.28NoNo082
65R:R:I226 R:R:V240 68.44273.07NoNo087
66A:A:L353 R:R:V240 68.26575.96YesNo077
67A:A:L353 R:R:S243 66.47493YesNo077
68R:R:A244 R:R:S243 66.29631.71NoNo067
69R:R:A244 R:R:N219 63.22984.69NoYes069
70R:R:I215 R:R:N219 62.26377.08YesYes489
71R:R:F251 R:R:I215 60.88493.77YesYes498
72R:R:F251 R:R:I130 59.50862.51YesYes497
73R:R:F208 R:R:I130 58.59913.77YesYes487
74R:R:K265 R:R:L262 13.81762.82YesYes456
75R:R:K265 R:R:L190 13.81974.23YesNo054
76R:R:D188 R:R:L190 11.2942.71NoNo054
77R:R:D188 R:R:F187 10.654810.75NoYes054
78A:A:F215 A:A:L37 50.35117.31YesYes199
79R:R:F208 R:R:Y258 14.42316.19YesYes487
80R:R:F208 R:R:I126 23.35522.51YesNo087
81R:R:I126 R:R:N125 23.17862.83NoNo079
82R:R:E88 R:R:N125 17.74382.63YesNo1099
83R:R:E88 R:R:N60 12.25110.52YesYes1099
84R:R:N60 R:R:P305 10.75874.89YesNo099
85R:R:P305 R:R:T63 10.54235.25NoYes098
86R:R:F208 R:R:Y127 12.72865.16YesNo088
87A:A:S263 A:A:Y320 10.48022.54NoYes077
88B:B:Q75 B:B:W99 65.30535.48YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8HQE
Class A
SubFamily Orphan
Type A orphans
SubType GPR132
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gi1/Beta1/Gamma2
PDB Resolution 2.97
Date 2023-10-11
D.O.I. 0.1038/s42255-023-00899-4
Net Summary
Imin 2.46
Number of Linked Nodes 848
Number of Links 1031
Number of Hubs 170
Number of Links mediated by Hubs 640
Number of Communities 25
Number of Nodes involved in Communities 251
Number of Links involved in Communities 357
Path Summary
Number Of Nodes in MetaPath 89
Number Of Links MetaPath 88
Number of Shortest Paths 1875713
Length Of Smallest Path 3
Average Path Length 36.2161
Length of Longest Path 78
Minimum Path Strength 1.255
Average Path Strength 5.65627
Maximum Path Strength 20.03
Minimum Path Correlation 0.7
Average Path Correlation 0.990433
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.63158
Average % Of Corr. Nodes 41.3054
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 56.6049
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8HQE_Chain_B
SELDQLRQE AEQLKNQIR DARKACADA TLSQITNNI DPVGRIQMR 
TRRTLRGHL AKIYAMHWG TDSRLLVSA SQDGKLIIW DSYTTNKVH 
AIPLRSSWV MTCAYAPSG NYVACGGLD NICSIYNLK TREGNVRVS 
RELAGHTGY LSCCRFLDD NQIVTSSGD TTCALWDIE TGQQTTTFT 
GHTGDVMSL SLAPDTRLF VSGACDASA KLWDVREGM CRQTFTGHE 
SDINAICFF PNGNAFATG SDDATCRLF DLRADQELM TYSHDNIIC 
GITSVSFSK SGRLLLAGY DDFNCNVWD ALKADRAGV LAGHDNRVS 
CLGVTDDGM AVATGSWDS FLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8HQE_Chain_G
SIAQARKLV EQLKMEANI DRIKVSKAA ADLMAYCEA HAKEDPLLT 
PVPASENPF R


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9UNW8
Sequence
>8HQE_Chain_R
SFEESRIVL VVVYSAVCT LGVPANCLT AWLALLQVL QGNVLAVYL 
LCLALCELL YTGTLPLWV IYIRNQHRW TLGLLACKV TAYIFFCNI 
YVSILFLCC ISCDRFVAV VYALESRGR RRRRTAILI SACIFILVG 
IVHYPVFQT EDKETCFDM LQMDSRIAG YYYARFTVG FAIPLSIIA 
FTNHRIFRS IKQSMGLSA AQKAKVKHS AIAVVVIFL VCFAPYHLV 
LLVKAAAFS YYRGAMCGL EERLYTASV VFLCLSTVN GVADPIIYV 
LATDHSRQE VSRIHKGWK EWSMKTDVT RLTHSRDTE E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63096
Sequence
>8HQE_Chain_A
LSAEDKAAV ERSKMIDRN LREDGEKAA REVKLLLLG AGESGKSTI 
VKQMKTGIV ETHFTFKDL HFKMFDVGA QRSERKKWI HCFEGVTAI 
IFCVALSDY DLVLMNRMH ESMKLFDSI CNNKWFTDT SIILFLNKK 
DLFEEKILT ICYPEYAGS NTYEEAAAY IQCQFEDLN KRKDTKEIY 
THFTCSTDT KNVQFVFDA VTDVIIKNN LKDCGLF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HQEAOrphanA orphansGPR132Homo sapiens--Gi1/&β;1/&γ;22.972023-10-110.1038/s42255-023-00899-4
8HQMAOrphanA orphansGPR132Homo sapiensNPGLY-Gi1/&β;1/&γ;22.952023-10-110.1038/s42255-023-00899-4
8HQNAOrphanA orphansGPR132Homo sapiens9(S)-HODE-Gi1/&β;1/&γ;232023-10-110.1038/s42255-023-00899-4
8HVIAOrphanA orphansGPR132Homo sapiensNOX-6-7-Gi1/&β;1/&γ;23.042023-10-110.1038/s42255-023-00899-4




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8HQE.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.