psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F38	R:R:R42	16.03	Yes	No	3	2	4
2	R:R:F38	R:R:Y287	5.16	Yes	Yes	0	2	4
3	R:R:S41	R:R:T288	3.2	No	No	0	4	2
4	R:R:Q105	R:R:R42	14.02	No	No	0	4	4
5	R:R:I43	R:R:R103	13.78	No	No	0	4	4
6	R:R:L45	R:R:V46	2.98	No	No	0	6	6
7	R:R:L45	R:R:V291	4.47	No	No	0	6	4
8	R:R:V46	R:R:V99	3.21	No	No	0	6	7
9	R:R:R103	R:R:V46	5.23	No	No	0	4	6
10	R:R:L95	R:R:Y49	4.69	No	No	0	8	8
11	R:R:T298	R:R:Y49	6.24	No	No	0	7	8
12	R:R:I100	R:R:S50	3.1	No	No	0	3	5
13	R:R:V299	R:R:V52	4.81	No	No	0	5	7
14	R:R:C53	R:R:P96	5.65	No	Yes	0	6	9
15	R:R:P58	R:R:V57	3.53	No	No	0	4	6
16	R:R:T92	R:R:V57	6.35	No	No	0	6	6
17	R:R:A59	R:R:I306	3.25	No	No	0	7	5
18	R:R:E88	R:R:N60	10.52	No	Yes	0	9	9
19	R:R:N60	R:R:T92	5.85	Yes	No	0	9	6
20	R:R:N60	R:R:V302	4.43	Yes	No	0	9	7
21	R:R:N60	R:R:P305	4.89	Yes	No	0	9	9
22	R:R:P305	R:R:T63	5.25	No	No	0	9	8
23	R:R:T63	R:R:V309	3.17	No	No	0	8	6
24	R:R:L68	R:R:W65	5.69	No	No	0	3	3
25	R:R:L69	R:R:W65	6.83	No	No	0	4	3
26	R:R:L66	R:R:L69	4.15	No	No	0	6	4
27	R:R:E318	R:R:L66	13.25	Yes	No	0	4	6
28	R:R:A67	R:R:L82	3.15	No	Yes	0	6	5
29	R:R:L69	R:R:R321	3.64	No	No	0	4	5
30	R:R:Q70	R:R:Q73	14.08	No	No	5	4	4
31	R:R:E318	R:R:Q70	12.74	Yes	No	0	4	4
32	R:R:A78	R:R:V71	3.39	No	Yes	0	6	5
33	R:R:V71	R:R:V79	3.21	Yes	No	0	5	6
34	R:R:L82	R:R:V71	4.47	Yes	Yes	0	5	5
35	R:R:R154	R:R:V76	11.77	Yes	No	0	7	6
36	R:R:D139	R:R:L77	6.79	No	No	0	8	7
37	R:R:I160	R:R:V79	4.61	No	No	0	3	6
38	R:R:C135	R:R:Y80	6.72	No	Yes	0	6	7
39	R:R:I136	R:R:Y80	6.04	No	Yes	0	8	7
40	R:R:A159	R:R:Y80	4	No	Yes	0	7	7
41	R:R:I162	R:R:Y80	4.84	Yes	Yes	0	4	7
42	R:R:L81	R:R:Y308	16.41	No	No	0	7	9
43	R:R:C83	R:R:F132	4.19	No	Yes	0	9	7
44	R:R:C83	R:R:S163	5.16	No	No	0	9	6
45	R:R:L84	R:R:S129	3	No	No	0	9	9
46	R:R:C87	R:R:V128	5.12	No	No	0	8	7
47	R:R:E88	R:R:Y91	11.22	No	No	0	9	7
48	R:R:E88	R:R:G301	3.27	No	No	0	9	7
49	R:R:N125	R:R:Y91	19.77	No	No	0	9	7
50	R:R:T298	R:R:Y91	7.49	No	No	0	7	7
51	R:R:G93	R:R:P96	6.09	No	Yes	0	4	9
52	R:R:L95	R:R:T94	2.95	No	No	4	8	6
53	R:R:T118	R:R:T94	3.14	No	No	4	5	6
54	R:R:L95	R:R:T118	2.95	No	No	4	8	5
55	R:R:W108	R:R:W98	4.69	Yes	Yes	0	9	6
56	R:R:L110	R:R:W98	10.25	No	Yes	0	6	6
57	R:R:A114	R:R:W98	3.89	No	Yes	0	5	6
58	R:R:C115	R:R:W98	5.22	No	Yes	0	9	6
59	R:R:T118	R:R:W98	7.28	No	Yes	0	5	6
60	R:R:N104	R:R:W108	5.65	No	Yes	0	4	9
61	R:R:F187	R:R:N104	3.62	Yes	No	0	4	4
62	R:R:Q105	R:R:R107	14.02	No	No	0	4	5
63	R:R:H106	R:R:T185	13.69	No	Yes	0	5	3
64	R:R:F187	R:R:H106	3.39	Yes	No	0	4	5
65	R:R:L112	R:R:W108	9.11	Yes	Yes	2	3	9
66	R:R:T185	R:R:W108	6.06	Yes	Yes	0	3	9
67	R:R:C186	R:R:W108	9.14	Yes	Yes	2	9	9
68	R:R:L110	R:R:T109	2.95	No	No	0	6	4
69	R:R:G111	R:R:L112	3.42	No	Yes	0	8	3
70	R:R:C115	R:R:L112	4.76	No	Yes	2	9	3
71	R:R:K183	R:R:L112	4.23	No	Yes	0	1	3
72	R:R:C186	R:R:L112	3.17	Yes	Yes	2	9	3
73	R:R:C115	R:R:C186	7.28	No	Yes	2	9	9
74	R:R:F178	R:R:K116	3.72	No	No	0	4	8
75	R:R:K116	R:R:K183	11.49	No	No	0	8	1
76	R:R:C186	R:R:K116	4.85	Yes	No	0	9	8
77	R:R:I121	R:R:V117	3.07	No	No	0	4	4
78	R:R:I121	R:R:Y120	3.63	No	No	0	4	5
79	R:R:H174	R:R:Y120	13.07	Yes	No	7	6	5
80	R:R:F178	R:R:Y120	7.22	No	No	7	4	5
81	R:R:F122	R:R:F123	6.43	No	Yes	0	6	5
82	R:R:F122	R:R:I126	5.02	No	No	0	6	7
83	R:R:F122	R:R:L294	4.87	No	No	0	6	6
84	R:R:F123	R:R:Y127	5.16	Yes	No	0	5	8
85	R:R:F123	R:R:H174	4.53	Yes	Yes	0	5	6
86	R:R:F123	R:R:Y200	4.13	Yes	Yes	0	5	5
87	R:R:C124	R:R:V170	5.12	No	No	0	5	7
88	R:R:V170	R:R:Y127	3.79	No	No	0	7	8
89	R:R:F208	R:R:Y127	5.16	Yes	No	0	8	8
90	R:R:F132	R:R:V128	6.55	Yes	No	0	7	7
91	R:R:V128	R:R:V170	3.21	No	No	0	7	7
92	R:R:F208	R:R:I130	3.77	Yes	No	0	8	7
93	R:R:I130	R:R:P211	3.39	No	No	0	7	9
94	R:R:F255	R:R:I130	8.79	No	No	0	9	7
95	R:R:I166	R:R:L131	4.28	No	No	0	6	5
96	R:R:F132	R:R:I166	6.28	Yes	No	0	7	6
97	R:R:F251	R:R:L133	4.87	Yes	No	0	9	8
98	R:R:C134	R:R:I214	3.27	No	No	0	7	6
99	R:R:I215	R:R:S137	3.1	Yes	No	0	8	9
100	R:R:S137	R:R:T218	6.4	No	No	0	9	6
101	R:R:D139	R:R:R154	11.91	No	Yes	0	8	7
102	R:R:F141	R:R:V145	5.24	No	No	0	8	7
103	R:R:F141	R:R:T218	3.89	No	No	0	8	6
104	R:R:F141	R:R:R221	4.28	No	No	0	8	4
105	R:R:S150	R:R:V142	4.85	No	No	0	6	5
106	R:R:I222	R:R:V144	4.61	No	No	0	8	8
107	R:R:V145	R:R:Y146	8.83	No	No	0	7	6
108	R:R:S225	R:R:V145	6.46	No	No	0	4	7
109	R:R:E149	R:R:Y146	4.49	No	No	0	4	6
110	R:R:E149	R:R:R153	4.65	No	No	0	4	4
111	R:R:R154	R:R:S150	3.95	Yes	No	0	7	6
112	R:R:R155	R:R:T158	7.76	No	No	0	6	2
113	R:R:R156	R:R:R157	10.66	No	No	0	3	4
114	R:R:H174	R:R:V177	15.22	Yes	No	0	6	5
115	R:R:F178	R:R:H174	4.53	No	Yes	7	4	6
116	R:R:P176	R:R:R203	5.76	No	No	0	8	5
117	R:R:R203	R:R:V177	3.92	No	No	0	5	5
118	R:R:M189	R:R:T185	6.02	No	Yes	0	4	3
119	R:R:D188	R:R:F187	10.75	No	Yes	0	5	4
120	R:R:F187	R:R:Y287	8.25	Yes	Yes	0	4	4
121	R:R:K265	R:R:L190	4.23	Yes	No	0	5	4
122	R:R:D193	R:R:R195	3.57	No	No	0	1	3
123	R:R:D193	R:R:I196	11.2	No	No	0	1	5
124	R:R:F269	R:R:S194	6.61	Yes	No	0	4	1
125	R:R:R273	R:R:S194	5.27	No	No	0	1	1
126	R:R:R195	R:R:Y199	16.46	No	No	0	3	4
127	R:R:R203	R:R:Y199	6.17	No	No	0	5	4
128	R:R:Y200	R:R:Y258	3.97	Yes	Yes	1	5	7
129	R:R:L262	R:R:Y200	11.72	No	Yes	1	6	5
130	R:R:K265	R:R:Y200	5.97	Yes	Yes	0	5	5
131	R:R:F204	R:R:Y201	4.13	Yes	Yes	0	5	4
132	R:R:T205	R:R:Y201	8.74	No	Yes	0	4	4
133	R:R:A266	R:R:Y201	8.01	No	Yes	0	5	4
134	R:R:F204	R:R:F208	7.5	Yes	Yes	1	5	8
135	R:R:F204	R:R:H259	5.66	Yes	No	1	5	8
136	R:R:F204	R:R:L262	10.96	Yes	No	1	5	6
137	R:R:F208	R:R:Y258	6.19	Yes	Yes	1	8	7
138	R:R:F208	R:R:H259	9.05	Yes	No	1	8	8
139	R:R:I210	R:R:P211	3.39	No	No	0	5	9
140	R:R:F251	R:R:L212	4.87	Yes	No	0	9	5
141	R:R:I215	R:R:N219	7.08	Yes	Yes	8	8	9
142	R:R:I215	R:R:V248	4.61	Yes	No	8	8	6
143	R:R:F251	R:R:I215	3.77	Yes	Yes	0	9	8
144	R:R:A244	R:R:N219	4.69	No	Yes	0	6	9
145	R:R:N219	R:R:V248	4.43	Yes	No	8	9	6
146	R:R:R221	R:R:R224	10.66	No	No	0	4	4
147	R:R:F223	R:R:K241	11.17	No	No	0	4	5
148	R:R:K227	R:R:R224	3.71	No	No	0	4	4
149	R:R:I226	R:R:L232	4.28	No	No	0	8	2
150	R:R:I226	R:R:V240	3.07	No	No	0	8	7
151	R:R:K227	R:R:K241	4.31	No	No	0	4	5
152	R:R:L232	R:R:Q236	13.31	No	Yes	0	2	5
153	R:R:Q236	R:R:S233	8.66	Yes	No	0	5	3
154	R:R:I250	R:R:N300	7.08	No	Yes	0	6	9
155	R:R:F251	R:R:F255	6.43	Yes	No	0	9	9
156	R:R:C254	R:R:N300	9.45	No	Yes	0	8	9
157	R:R:F293	R:R:P257	5.78	Yes	No	0	7	9
158	R:R:L262	R:R:Y258	5.86	No	Yes	1	6	7
159	R:R:L294	R:R:Y258	5.86	No	Yes	0	6	7
160	R:R:F293	R:R:V261	5.24	Yes	No	0	7	5
161	R:R:F269	R:R:K265	4.96	Yes	Yes	0	4	5
162	R:R:K265	R:R:L286	4.23	Yes	No	0	5	4
163	R:R:E283	R:R:F269	3.5	No	Yes	0	3	4
164	R:R:Y271	R:R:Y272	3.97	No	No	0	2	1
165	R:R:C280	R:R:G281	3.92	No	No	0	8	2
166	R:R:E283	R:R:L286	5.3	No	No	0	3	4
167	R:R:R285	R:R:T288	3.88	No	No	0	2	2
168	R:R:S290	R:R:Y287	3.82	No	Yes	0	5	4
169	R:R:V291	R:R:Y287	5.05	No	Yes	0	4	4
170	R:R:F293	R:R:L296	4.87	Yes	No	0	7	8
171	R:R:L294	R:R:S297	4.5	No	No	0	6	8
172	R:R:G301	R:R:N300	3.39	No	Yes	6	7	9
173	R:R:D304	R:R:N300	8.08	No	Yes	6	9	9
174	R:R:D304	R:R:G301	3.35	No	No	6	9	7
175	R:R:A303	R:R:I307	3.25	No	No	0	6	7
176	R:R:V309	R:R:Y308	3.79	No	No	0	6	9
177	R:R:S315	R:R:V309	3.23	No	No	0	7	6
178	R:R:L310	R:R:R316	3.64	No	No	0	7	8
179	R:R:S315	R:R:T312	3.2	No	No	0	7	7
180	R:R:H314	R:R:Q317	7.42	No	No	0	6	4
181	R:R:E318	R:R:H314	3.69	Yes	No	0	4	6
182	R:R:E318	R:R:R321	9.3	Yes	No	0	4	5
183	R:R:I322	R:R:R321	8.77	No	No	0	4	5
184	R:R:H323	R:R:K327	11.79	No	No	0	3	2
185	R:R:S330	R:R:W326	3.71	No	No	0	5	1
186	R:R:K327	R:R:K332	7.18	No	No	0	2	4
187	R:R:K332	R:R:S330	6.12	No	No	0	4	5
188	R:R:M331	R:R:R337	4.96	No	No	0	4	6
189	R:R:D334	R:R:R337	9.53	No	No	0	5	6
190	R:R:T336	R:R:T339	3.14	No	No	0	6	5
191	R:R:H340	R:R:T344	5.48	No	No	0	7	8
192	R:R:R342	R:R:S341	5.27	No	No	0	8	7
193	R:R:E345	R:R:R342	10.47	No	No	0	6	8
194	R:R:I162	R:R:I166	2.94	Yes	No	0	4	6
195	R:R:A238	R:R:H242	2.93	No	No	0	4	5
196	R:R:E318	R:R:S315	2.87	Yes	No	0	4	7
197	R:R:I121	R:R:L90	2.85	No	No	0	4	7
198	R:R:C87	R:R:F167	2.79	No	No	0	8	9
199	R:R:P96	R:R:Y49	2.78	Yes	No	0	9	8
200	R:R:L68	R:R:L82	2.77	No	Yes	0	3	5
201	R:R:L82	R:R:L86	2.77	Yes	No	0	5	5
202	R:R:A143	R:R:R154	2.77	No	Yes	0	8	7
203	R:R:A197	R:R:F269	2.77	No	Yes	0	4	4
204	R:R:E149	R:R:L148	2.65	No	No	0	4	5
205	R:R:N75	R:R:Q70	2.64	No	No	5	7	4
206	R:R:N75	R:R:Q73	2.64	No	No	5	7	4
207	R:R:F293	R:R:V292	2.62	Yes	No	0	7	5
208	R:R:D182	R:R:E181	2.6	No	No	0	5	5
209	R:R:I102	R:R:R103	2.51	No	No	0	6	4
210	R:R:I102	R:R:R107	2.51	No	No	0	6	5
211	R:R:I160	R:R:R156	2.51	No	No	0	3	3
212	R:R:F269	R:R:M279	2.49	Yes	No	0	4	4
213	R:R:F132	R:R:L84	2.44	Yes	No	0	7	9
214	R:R:L77	R:R:R140	2.43	No	No	0	7	9
215	R:R:L263	R:R:Y201	2.34	No	Yes	0	5	4
216	R:R:E39	R:R:F38	2.33	No	Yes	3	3	2
217	R:R:E39	R:R:R42	2.33	No	No	3	3	4
218	R:R:F223	R:R:H220	2.26	No	No	0	4	4
219	R:R:H220	R:R:R224	2.26	No	No	0	4	4
220	R:R:Q191	R:R:Y287	2.25	No	Yes	0	4	4
221	R:R:C134	R:R:P211	1.88	No	No	0	7	9
222	R:R:A256	R:R:P257	1.87	No	No	0	4	9
223	R:R:G56	R:R:V302	1.84	No	No	0	8	7
224	R:R:G207	R:R:V206	1.84	No	No	0	6	4
225	R:R:A64	R:R:A85	1.79	No	No	0	7	8
226	R:R:G231	R:R:M230	1.75	No	No	0	2	3
227	R:R:C295	R:R:V48	1.71	No	No	0	5	5
228	R:R:G56	R:R:L55	1.71	No	No	0	8	5
229	R:R:A244	R:R:S243	1.71	No	No	0	6	7
230	R:R:C254	R:R:V253	1.71	No	No	0	8	5
231	R:R:G74	R:R:N75	1.7	No	No	0	5	7
232	R:R:A159	R:R:V76	1.7	No	No	0	7	6
233	R:R:A289	R:R:V261	1.7	No	No	0	6	5
234	R:R:I100	R:R:P96	1.69	No	Yes	0	3	9
235	R:R:C138	R:R:T218	1.69	No	No	0	6	6
236	R:R:A311	R:R:T312	1.68	No	No	0	5	7
237	R:R:E328	R:R:G325	1.64	No	No	0	3	4
238	R:R:S41	R:R:V292	1.62	No	No	0	4	5
239	R:R:S225	R:R:V144	1.62	No	No	0	4	8
240	R:R:S243	R:R:V240	1.62	No	No	0	7	7
241	R:R:V302	R:R:V52	1.6	No	No	0	7	7
242	R:R:T180	R:R:V177	1.59	No	No	0	4	5
243	R:R:C254	R:R:L296	1.59	No	No	0	8	8
244	R:R:T333	R:R:V335	1.59	No	No	0	5	4
245	R:R:A64	R:R:L89	1.58	No	No	0	7	7
246	R:R:P176	R:R:Q179	1.58	No	No	0	8	4
247	R:R:A256	R:R:L252	1.58	No	No	0	4	5
248	R:R:I43	R:R:V44	1.54	No	No	0	4	4
249	R:R:I245	R:R:V248	1.54	No	No	0	4	6
250	R:R:I245	R:R:V249	1.54	No	No	0	4	4
251	R:R:I162	R:R:T158	1.52	Yes	No	0	4	2
252	R:R:A235	R:R:Q236	1.52	No	Yes	0	3	5
253	R:R:F208	R:R:G207	1.51	Yes	No	0	8	6
254	R:R:G274	R:R:R273	1.5	No	No	0	3	1
255	R:R:L62	R:R:V319	1.49	No	No	0	5	5
256	R:R:L72	R:R:V71	1.49	No	Yes	0	6	5
257	R:R:L169	R:R:V173	1.49	No	No	0	4	5
258	R:R:L260	R:R:V261	1.49	No	No	0	5	5
259	R:R:L286	R:R:V264	1.49	No	No	0	4	4
260	R:R:N219	R:R:V247	1.48	Yes	No	0	9	8
261	R:R:L62	R:R:T63	1.47	No	No	0	5	8
262	R:R:L89	R:R:T92	1.47	No	No	0	7	6
263	R:R:I168	R:R:I172	1.47	No	No	0	3	3
264	R:R:I250	R:R:I307	1.47	No	No	0	6	7
265	R:R:G198	R:R:Y201	1.45	No	Yes	0	3	4
266	R:R:E40	R:R:S41	1.44	No	No	0	3	4
267	R:R:Q228	R:R:S225	1.44	No	No	0	4	4
268	R:R:I162	R:R:L161	1.43	Yes	No	0	4	3
269	R:R:E184	R:R:T185	1.41	No	Yes	0	4	3
270	R:R:P176	R:R:Y175	1.39	No	No	0	8	4
271	R:R:D182	R:R:M189	1.39	No	No	0	5	4
272	R:R:D313	R:R:K239	1.38	No	No	0	5	7
273	R:R:K239	R:R:Q236	1.36	No	Yes	0	7	5
274	R:R:D334	R:R:L338	1.36	No	No	0	5	4
275	R:R:F38	R:R:S37	1.32	Yes	No	0	2	5
276	R:R:H242	R:R:K241	1.31	No	No	0	5	5
277	R:R:R337	R:R:T336	1.29	No	No	0	6	6
278	R:R:L110	R:R:Y101	1.17	No	No	0	6	5
279	R:R:L97	R:R:W98	1.14	No	Yes	0	6	6
280	R:R:E328	R:R:W329	1.09	No	No	0	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F38	6.21	4	3	2
2	R:R:N60	6.4225	4	0	9
3	R:R:V71	3.14	4	0	5
4	R:R:Y80	5.4	4	0	7
5	R:R:L82	3.29	4	0	5
6	R:R:P96	4.0525	4	0	9
7	R:R:W98	5.41167	6	0	6
8	R:R:W108	6.93	5	2	9
9	R:R:L112	4.938	5	2	3
10	R:R:F123	5.0625	4	0	5
11	R:R:F132	4.865	4	0	7
12	R:R:R154	7.6	4	0	7
13	R:R:I162	2.6825	4	0	4
14	R:R:H174	9.3375	4	7	6
15	R:R:T185	6.795	4	0	3
16	R:R:C186	6.11	4	2	9
17	R:R:F187	6.5025	4	0	4
18	R:R:Y200	6.4475	4	1	5
19	R:R:Y201	4.934	5	0	4
20	R:R:F204	7.0625	4	1	5
21	R:R:F208	5.53	6	1	8
22	R:R:I215	4.64	4	8	8
23	R:R:N219	4.42	4	8	9
24	R:R:Q236	6.2125	4	0	5
25	R:R:F251	4.985	4	0	9
26	R:R:Y258	5.47	4	1	7
27	R:R:K265	4.8475	4	0	5
28	R:R:F269	4.066	5	0	4
29	R:R:Y287	4.906	5	0	4
30	R:R:F293	4.6275	4	0	7
31	R:R:N300	7	4	6	9
32	R:R:E318	8.37	5	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F187	R:R:Y287	14.8279	8.25	Yes	Yes	0	4	4
2	R:R:F187	R:R:N104	15.9379	3.62	Yes	No	0	4	4
3	R:R:N104	R:R:W108	16.678	5.65	No	Yes	0	4	9
4	R:R:W108	R:R:W98	53.32	4.69	Yes	Yes	0	9	6
5	R:R:T118	R:R:W98	93.377	7.28	No	Yes	0	5	6
6	R:R:L95	R:R:T118	91.6525	2.95	No	No	4	8	5
7	R:R:L95	R:R:Y49	91.2384	4.69	No	No	0	8	8
8	R:R:T298	R:R:Y49	86.7778	6.24	No	No	0	7	8
9	R:R:T298	R:R:Y91	86.0106	7.49	No	No	0	7	7
10	R:R:E88	R:R:Y91	84.4558	11.22	No	No	0	9	7
11	R:R:E88	R:R:G301	26.3731	3.27	No	No	0	9	7
12	R:R:G301	R:R:N300	23.9256	3.39	No	Yes	6	7	9
13	R:R:C254	R:R:N300	19.1425	9.45	No	Yes	0	8	9
14	R:R:C254	R:R:L296	16.678	1.59	No	No	0	8	8
15	R:R:F293	R:R:L296	15.4355	4.87	Yes	No	0	7	8
16	R:R:E88	R:R:N60	65.5611	10.52	No	Yes	0	9	9
17	R:R:N60	R:R:P305	53.8699	4.89	Yes	No	0	9	9
18	R:R:P305	R:R:T63	52.8515	5.25	No	No	0	9	8
19	R:R:T63	R:R:V309	49.7556	3.17	No	No	0	8	6
20	R:R:S315	R:R:V309	46.5985	3.23	No	No	0	7	6
21	R:R:E318	R:R:S315	43.3804	2.87	Yes	No	0	4	7
22	R:R:E318	R:R:L66	17.2076	13.25	Yes	No	0	4	6
23	R:R:L66	R:R:L69	16.0228	4.15	No	No	0	6	4
24	R:R:L69	R:R:W65	29.6524	6.83	No	No	0	4	3
25	R:R:L68	R:R:W65	27.2184	5.69	No	No	0	3	3
26	R:R:E318	R:R:R321	18.4364	9.3	Yes	No	0	4	5
27	R:R:L69	R:R:R321	16.0669	3.64	No	No	0	4	5
28	R:R:L68	R:R:L82	24.7776	2.77	No	Yes	0	3	5
29	R:R:L82	R:R:V71	17.4146	4.47	Yes	Yes	0	5	5
30	R:R:C186	R:R:W108	55.2515	9.14	Yes	Yes	2	9	9
31	R:R:C186	R:R:K116	99.0529	4.85	Yes	No	0	9	8
32	R:R:F178	R:R:K116	100	3.72	No	No	0	4	8
33	R:R:F178	R:R:H174	96.4763	4.53	No	Yes	7	4	6
34	R:R:F123	R:R:H174	93.4211	4.53	Yes	Yes	0	5	6
35	R:R:F123	R:R:Y127	73.9867	5.16	Yes	No	0	5	8
36	R:R:V170	R:R:Y127	31.2682	3.79	No	No	0	7	8
37	R:R:V128	R:R:V170	29.2111	3.21	No	No	0	7	7
38	R:R:F132	R:R:V128	26.0744	6.55	Yes	No	0	7	7
39	R:R:F132	R:R:I166	20.7108	6.28	Yes	No	0	7	6
40	R:R:I162	R:R:I166	18.5179	2.94	Yes	No	0	4	6
41	R:R:I162	R:R:Y80	14.0505	4.84	Yes	Yes	0	4	7
42	R:R:A159	R:R:Y80	10.6287	4	No	Yes	0	7	7
43	R:R:C115	R:R:W98	44.3377	5.22	No	Yes	0	9	6
44	R:R:C115	R:R:C186	43.4449	7.28	No	Yes	2	9	9
45	R:R:F123	R:R:Y200	19.2477	4.13	Yes	Yes	0	5	5
46	R:R:F208	R:R:Y127	53.7002	5.16	Yes	No	0	8	8
47	R:R:F208	R:R:I130	48.3638	3.77	Yes	No	0	8	7
48	R:R:F255	R:R:I130	43.7878	8.79	No	No	0	9	7
49	R:R:F251	R:R:F255	42.8678	6.43	Yes	No	0	9	9
50	R:R:F251	R:R:I215	40.0197	3.77	Yes	Yes	0	9	8
51	R:R:I215	R:R:S137	23.8577	3.1	Yes	No	0	8	9
52	R:R:S137	R:R:T218	22.8087	6.4	No	No	0	9	6
53	R:R:F141	R:R:T218	20.6497	3.89	No	No	0	8	6
54	R:R:F141	R:R:V145	10.5981	5.24	No	No	0	8	7
55	R:R:H174	R:R:V177	11.8304	15.22	Yes	No	0	6	5
56	R:R:K265	R:R:Y200	13.9283	5.97	Yes	Yes	0	5	5
57	R:R:F204	R:R:Y201	10.2824	4.13	Yes	Yes	0	5	4
58	R:R:I215	R:R:N219	13.8842	7.08	Yes	Yes	8	8	9
59	R:R:A244	R:R:N219	11.7421	4.69	No	Yes	0	6	9
60	R:R:A244	R:R:S243	10.5981	1.71	No	No	0	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8HQE_nogp

PDB Summary
PDB	8HQE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	275
Number of Links	280
Number of Hubs	32
Number of Links mediated by Hubs	119
Number of Communities	8
Number of Nodes involved in Communities	28
Number of Links involved in Communities	31

Path Summary
Number Of Nodes in MetaPath	61
Number Of Links MetaPath	60
Number of Shortest Paths	45789
Length Of Smallest Path	3
Average Path Length	19.5072
Length of Longest Path	44
Minimum Path Strength	1.365
Average Path Strength	5.47951
Maximum Path Strength	15.495
Minimum Path Correlation	0.7
Average Path Correlation	0.972192
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	59.3339
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.2803
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • mitotic cell cycle process • cell cycle phase transition • cell cycle • G1/S transition of mitotic cell cycle • cell cycle G1/S phase transition • mitotic cell cycle • mitotic cell cycle phase transition • cell cycle process • regulation of cell cycle phase transition • G2/M transition of mitotic cell cycle • negative regulation of biological process • negative regulation of cell cycle • negative regulation of mitotic cell cycle • regulation of mitotic cell cycle • negative regulation of cellular process • negative regulation of cell cycle phase transition • regulation of cell cycle • cell cycle G2/M phase transition • negative regulation of mitotic cell cycle phase transition • regulation of G2/M transition of mitotic cell cycle • regulation of cell cycle process • regulation of cell cycle G2/M phase transition • negative regulation of cell cycle process • regulation of mitotic cell cycle phase transition • negative regulation of cell cycle G2/M phase transition • negative regulation of G2/M transition of mitotic cell cycle • periplasmic space • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UNW8
Sequence	>8HQE_nogp_Chain_R S F E E S R I V L V V V Y S A V C T L G V P A N C L T A W L A L L Q V L Q G N V L A V Y L L C L A L C E L L Y T G T L P L W V I Y I R N Q H R W T L G L L A C K V T A Y I F F C N I Y V S I L F L C C I S C D R F V A V V Y A L E S R G R R R R R T A I L I S A C I F I L V G I V H Y P V F Q T E D K E T C F D M L Q M D S R I A G Y Y Y A R F T V G F A I P L S I I A F T N H R I F R S I K Q S M G L S A A Q K A K V K H S A I A V V V I F L V C F A P Y H L V L L V K A A A F S Y Y R G A M C G L E E R L Y T A S V V F L C L S T V N G V A D P I I Y V L A T D H S R Q E V S R I H K G W K E W S M K T D V T R L T H S R D T E E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HQE	A	Orphan	Orphan	GPR132	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQE (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	-	-		2.97	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQM	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-	Gi1/β1/γ2	2.95	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQM (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-		2.95	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQN	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-	Gi1/β1/γ2	3	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQN (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-		3	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HVI	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-	Gi1/β1/γ2	3.04	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HVI (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-		3.04	2023-10-11	doi.org/10.1038/s42255-023-00899-4

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