psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H106	17.33	Yes	Yes	1	0	5
2	L:L:?1	R:R:E184	7.94	Yes	No	0	0	4
3	L:L:?1	R:R:T185	11.04	Yes	No	0	0	3
4	L:L:?1	R:R:D188	5.08	Yes	Yes	1	0	5
5	L:L:?1	R:R:Q191	23.92	Yes	No	0	0	4
6	L:L:?1	R:R:E283	10.91	Yes	Yes	0	0	3
7	L:L:?1	R:R:Y287	19.31	Yes	Yes	1	0	4
8	R:R:F38	R:R:R42	5.34	Yes	Yes	1	2	4
9	R:R:F38	R:R:Q105	4.68	Yes	Yes	1	2	4
10	R:R:F38	R:R:H106	5.66	Yes	Yes	1	2	5
11	R:R:F38	R:R:Y287	5.16	Yes	Yes	1	2	4
12	R:R:E39	R:R:E40	3.81	No	No	0	3	3
13	R:R:E39	R:R:Q105	3.82	No	Yes	0	3	4
14	R:R:E40	R:R:S41	4.31	No	No	0	3	4
15	R:R:N104	R:R:R42	8.44	No	Yes	0	4	4
16	R:R:Q105	R:R:R42	7.01	Yes	Yes	1	4	4
17	R:R:H106	R:R:R42	16.93	Yes	Yes	1	5	4
18	R:R:F187	R:R:R42	3.21	Yes	Yes	1	4	4
19	R:R:R42	R:R:Y287	6.17	Yes	Yes	1	4	4
20	R:R:I43	R:R:R103	5.01	No	No	0	4	4
21	R:R:L45	R:R:Y49	5.86	Yes	Yes	5	6	8
22	R:R:L45	R:R:V291	2.98	Yes	No	0	6	4
23	R:R:C295	R:R:L45	3.17	No	Yes	5	5	6
24	R:R:V46	R:R:V99	8.02	No	No	4	6	7
25	R:R:L294	R:R:Y49	7.03	No	Yes	0	6	8
26	R:R:C295	R:R:Y49	8.06	No	Yes	5	5	8
27	R:R:P96	R:R:S50	3.56	Yes	No	0	9	5
28	R:R:V299	R:R:V52	3.21	No	No	0	5	7
29	R:R:C53	R:R:P96	7.53	No	Yes	0	6	9
30	R:R:P58	R:R:V57	5.3	No	No	0	4	6
31	R:R:L89	R:R:V57	5.96	Yes	No	0	7	6
32	R:R:A59	R:R:I306	3.25	No	No	0	7	5
33	R:R:E88	R:R:N60	5.26	No	Yes	0	9	9
34	R:R:L89	R:R:N60	15.1	Yes	Yes	0	7	9
35	R:R:N60	R:R:V302	5.91	Yes	No	0	9	7
36	R:R:N60	R:R:P305	3.26	Yes	No	0	9	9
37	R:R:P305	R:R:T63	6.99	No	No	0	9	8
38	R:R:L68	R:R:W65	5.69	No	No	0	3	3
39	R:R:L69	R:R:W65	6.83	No	No	0	4	3
40	R:R:I322	R:R:L66	2.85	No	No	0	4	6
41	R:R:L69	R:R:R321	4.86	No	No	0	4	5
42	R:R:A78	R:R:Q70	3.03	No	No	0	6	4
43	R:R:L82	R:R:V71	5.96	No	No	0	5	5
44	R:R:G74	R:R:R156	3	No	No	0	5	3
45	R:R:L77	R:R:N75	8.24	No	No	0	7	7
46	R:R:A78	R:R:N75	4.69	No	No	0	6	7
47	R:R:N75	R:R:R154	9.64	No	No	0	7	7
48	R:R:R154	R:R:V76	7.85	No	No	0	7	6
49	R:R:A159	R:R:V76	5.09	No	No	0	7	6
50	R:R:L77	R:R:R140	15.79	No	No	0	7	9
51	R:R:F132	R:R:Y80	4.13	Yes	Yes	2	7	7
52	R:R:C135	R:R:Y80	5.38	No	Yes	2	6	7
53	R:R:I136	R:R:Y80	4.84	No	Yes	0	8	7
54	R:R:A159	R:R:Y80	2.67	No	Yes	0	7	7
55	R:R:I162	R:R:Y80	3.63	No	Yes	0	4	7
56	R:R:L81	R:R:Y308	7.03	No	No	0	7	9
57	R:R:L82	R:R:L86	2.77	No	No	0	5	5
58	R:R:C83	R:R:F132	4.19	No	Yes	0	9	7
59	R:R:F132	R:R:L84	3.65	Yes	No	0	7	9
60	R:R:C87	R:R:N125	3.15	No	No	0	8	9
61	R:R:C87	R:R:V128	3.42	No	No	0	8	7
62	R:R:L89	R:R:T92	2.95	Yes	No	0	7	6
63	R:R:G93	R:R:L89	3.42	No	Yes	0	4	7
64	R:R:L95	R:R:Y91	5.86	No	Yes	3	8	7
65	R:R:W98	R:R:Y91	4.82	Yes	Yes	3	6	7
66	R:R:T118	R:R:Y91	3.75	No	Yes	3	5	7
67	R:R:F122	R:R:Y91	7.22	Yes	Yes	0	6	7
68	R:R:L97	R:R:T94	2.95	No	No	0	6	6
69	R:R:T94	R:R:W98	7.28	No	Yes	0	6	6
70	R:R:L95	R:R:W98	4.56	No	Yes	3	8	6
71	R:R:T118	R:R:W98	4.85	No	Yes	3	5	6
72	R:R:I102	R:R:Y101	12.09	No	No	0	6	5
73	R:R:I102	R:R:R107	3.76	No	No	0	6	5
74	R:R:Q105	R:R:R107	7.01	Yes	No	0	4	5
75	R:R:F187	R:R:H106	4.53	Yes	Yes	1	4	5
76	R:R:H106	R:R:Y287	8.71	Yes	Yes	1	5	4
77	R:R:L112	R:R:W108	5.69	No	No	0	3	9
78	R:R:C115	R:R:W108	3.92	No	No	0	9	9
79	R:R:F187	R:R:W108	4.01	Yes	No	0	4	9
80	R:R:L110	R:R:T109	4.42	No	No	0	6	4
81	R:R:K116	R:R:L112	2.82	No	No	0	8	3
82	R:R:C115	R:R:T118	3.38	No	No	0	9	5
83	R:R:C115	R:R:C186	7.28	No	No	0	9	9
84	R:R:K116	R:R:K183	15.8	No	No	0	8	1
85	R:R:C186	R:R:K116	8.08	No	No	0	9	8
86	R:R:I121	R:R:Y120	4.84	No	Yes	0	4	5
87	R:R:C124	R:R:Y120	5.38	No	Yes	0	5	5
88	R:R:H174	R:R:Y120	14.16	Yes	Yes	0	6	5
89	R:R:I121	R:R:N125	2.83	No	No	0	4	9
90	R:R:F122	R:R:F123	6.43	Yes	Yes	0	6	5
91	R:R:F122	R:R:I126	6.28	Yes	No	0	6	7
92	R:R:F122	R:R:L294	4.87	Yes	No	0	6	6
93	R:R:F123	R:R:Y127	5.16	Yes	No	0	5	8
94	R:R:F123	R:R:H174	4.53	Yes	Yes	0	5	6
95	R:R:F123	R:R:Y200	8.25	Yes	Yes	0	5	5
96	R:R:C124	R:R:V170	5.12	No	No	0	5	7
97	R:R:F208	R:R:Y127	6.19	Yes	No	0	8	8
98	R:R:F132	R:R:V128	2.62	Yes	No	0	7	7
99	R:R:V128	R:R:V170	4.81	No	No	0	7	7
100	R:R:I130	R:R:P211	3.39	Yes	No	0	7	9
101	R:R:F251	R:R:I130	8.79	Yes	Yes	1	9	7
102	R:R:F255	R:R:I130	6.28	Yes	Yes	1	9	7
103	R:R:H259	R:R:I130	2.65	Yes	Yes	1	8	7
104	R:R:I166	R:R:L131	5.71	Yes	No	0	6	5
105	R:R:C135	R:R:F132	4.19	No	Yes	2	6	7
106	R:R:F132	R:R:S163	2.64	Yes	No	0	7	6
107	R:R:F132	R:R:I166	7.54	Yes	Yes	2	7	6
108	R:R:I215	R:R:L133	4.28	Yes	No	0	8	8
109	R:R:C134	R:R:I214	4.91	No	No	0	7	6
110	R:R:C134	R:R:I215	3.27	No	Yes	0	7	8
111	R:R:C135	R:R:I166	3.27	No	Yes	2	6	6
112	R:R:I215	R:R:S137	3.1	Yes	No	0	8	9
113	R:R:S137	R:R:T218	4.8	No	No	0	9	6
114	R:R:D139	R:R:R140	3.57	No	No	0	8	9
115	R:R:F141	R:R:V145	2.62	No	No	0	8	7
116	R:R:F141	R:R:T218	5.19	No	No	0	8	6
117	R:R:F141	R:R:R221	5.34	No	Yes	0	8	4
118	R:R:V142	R:R:Y146	3.79	No	No	0	5	6
119	R:R:E149	R:R:V142	4.28	No	No	0	4	5
120	R:R:S150	R:R:V142	6.46	No	No	0	6	5
121	R:R:A143	R:R:S150	3.42	No	No	0	8	6
122	R:R:S225	R:R:V144	4.85	No	No	0	4	8
123	R:R:V145	R:R:Y146	10.09	No	No	0	7	6
124	R:R:E149	R:R:R153	6.98	No	No	0	4	4
125	R:R:G152	R:R:R153	4.5	No	No	0	4	4
126	R:R:R155	R:R:R157	6.4	No	No	0	6	4
127	R:R:R155	R:R:T158	6.47	No	No	0	6	2
128	R:R:R156	R:R:R157	14.93	No	No	0	3	4
129	R:R:I162	R:R:I166	2.94	No	Yes	0	4	6
130	R:R:H174	R:R:V177	12.45	Yes	No	0	6	5
131	R:R:Q179	R:R:Y175	14.65	No	No	0	4	4
132	R:R:P176	R:R:Y199	2.78	No	No	1	8	4
133	R:R:P176	R:R:R203	2.88	No	Yes	1	8	5
134	R:R:R203	R:R:V177	5.23	Yes	No	0	5	5
135	R:R:F178	R:R:Q179	7.03	No	No	0	4	4
136	R:R:K183	R:R:T180	6.01	No	No	0	1	4
137	R:R:I196	R:R:T180	4.56	No	No	0	5	4
138	R:R:D182	R:R:M189	4.16	No	Yes	0	5	4
139	R:R:D182	R:R:D193	6.65	No	No	0	5	1
140	R:R:F187	R:R:T185	6.49	Yes	No	0	4	3
141	R:R:M189	R:R:T185	3.01	Yes	No	0	4	3
142	R:R:F187	R:R:Y287	6.19	Yes	Yes	1	4	4
143	R:R:D188	R:R:L190	16.29	Yes	Yes	1	5	4
144	R:R:D188	R:R:Y200	11.49	Yes	Yes	1	5	5
145	R:R:D188	R:R:K265	6.91	Yes	Yes	1	5	5
146	R:R:M189	R:R:Q191	2.72	Yes	No	0	4	4
147	R:R:I196	R:R:M189	4.37	No	Yes	0	5	4
148	R:R:A197	R:R:L190	3.15	No	Yes	0	4	4
149	R:R:L190	R:R:Y200	8.21	Yes	Yes	1	4	5
150	R:R:K265	R:R:L190	2.82	Yes	Yes	1	5	4
151	R:R:A266	R:R:L190	3.15	No	Yes	0	5	4
152	R:R:F269	R:R:Q191	4.68	No	No	0	4	4
153	R:R:D193	R:R:M192	2.77	No	No	0	1	3
154	R:R:D193	R:R:I196	4.2	No	No	0	1	5
155	R:R:R273	R:R:S194	13.18	No	No	0	1	1
156	R:R:G198	R:R:R195	3	No	No	0	3	3
157	R:R:R195	R:R:Y199	10.29	No	No	0	3	4
158	R:R:R203	R:R:Y199	5.14	Yes	No	1	5	4
159	R:R:R203	R:R:Y200	5.14	Yes	Yes	1	5	5
160	R:R:Y200	R:R:Y258	2.98	Yes	Yes	1	5	7
161	R:R:L262	R:R:Y200	12.89	No	Yes	1	6	5
162	R:R:T205	R:R:Y201	6.24	No	No	0	4	4
163	R:R:F204	R:R:F208	7.5	No	Yes	1	5	8
164	R:R:F204	R:R:H259	4.53	No	Yes	1	5	8
165	R:R:F204	R:R:L263	3.65	No	No	0	5	5
166	R:R:G207	R:R:P211	4.06	No	No	0	6	9
167	R:R:F208	R:R:Y258	3.09	Yes	Yes	1	8	7
168	R:R:F208	R:R:H259	31.68	Yes	Yes	1	8	8
169	R:R:I210	R:R:P211	3.39	No	No	0	5	9
170	R:R:I210	R:R:I214	2.94	No	No	6	5	6
171	R:R:I215	R:R:N219	4.25	Yes	Yes	0	8	9
172	R:R:F251	R:R:I215	3.77	Yes	Yes	0	9	8
173	R:R:F217	R:R:R221	8.55	No	Yes	0	4	4
174	R:R:I222	R:R:N219	4.25	No	Yes	0	8	9
175	R:R:A244	R:R:N219	3.13	No	Yes	0	6	9
176	R:R:N219	R:R:V248	4.43	Yes	No	0	9	6
177	R:R:H220	R:R:R221	5.64	No	Yes	0	4	4
178	R:R:R221	R:R:R224	13.86	Yes	No	0	4	4
179	R:R:F223	R:R:K241	16.13	Yes	No	0	4	5
180	R:R:A244	R:R:F223	4.16	No	Yes	0	6	4
181	R:R:I226	R:R:L232	5.71	No	No	0	8	2
182	R:R:I226	R:R:V240	4.61	No	No	7	8	7
183	R:R:I226	R:R:K241	5.82	No	No	7	8	5
184	R:R:L232	R:R:S229	4.5	No	No	0	2	5
185	R:R:L232	R:R:Q236	3.99	No	No	0	2	5
186	R:R:Q236	R:R:S233	5.78	No	No	0	5	3
187	R:R:A238	R:R:H242	2.93	No	No	0	4	5
188	R:R:D313	R:R:K239	9.68	No	No	0	5	7
189	R:R:K241	R:R:V240	3.04	No	No	7	5	7
190	R:R:I250	R:R:N300	9.91	No	Yes	0	6	9
191	R:R:I250	R:R:I307	5.89	No	Yes	0	6	7
192	R:R:F251	R:R:L252	3.65	Yes	No	0	9	5
193	R:R:F251	R:R:F255	7.5	Yes	Yes	1	9	9
194	R:R:C254	R:R:N300	9.45	No	Yes	0	8	9
195	R:R:F255	R:R:S297	2.64	Yes	No	0	9	8
196	R:R:F255	R:R:N300	13.29	Yes	Yes	0	9	9
197	R:R:F293	R:R:P257	4.33	No	No	0	7	9
198	R:R:H259	R:R:Y258	4.36	Yes	Yes	1	8	7
199	R:R:L262	R:R:Y258	18.76	No	Yes	1	6	7
200	R:R:F293	R:R:V261	3.93	No	Yes	0	7	5
201	R:R:K265	R:R:L262	2.82	Yes	No	1	5	6
202	R:R:K265	R:R:S290	3.06	Yes	No	0	5	5
203	R:R:A267	R:R:Y271	4	No	No	0	4	2
204	R:R:A268	R:R:Y272	2.67	No	No	0	3	1
205	R:R:F269	R:R:R273	7.48	No	No	0	4	1
206	R:R:E283	R:R:F269	4.66	Yes	No	0	3	4
207	R:R:S270	R:R:Y271	3.82	No	No	0	3	2
208	R:R:Y271	R:R:Y272	6.95	No	No	0	2	1
209	R:R:L282	R:R:M279	2.83	No	No	0	1	4
210	R:R:E283	R:R:M279	10.83	Yes	No	0	3	4
211	R:R:C280	R:R:E283	3.04	No	Yes	0	8	3
212	R:R:E284	R:R:G281	3.27	No	No	0	4	2
213	R:R:L282	R:R:R285	4.86	No	No	8	1	2
214	R:R:L282	R:R:L286	2.77	No	No	8	1	4
215	R:R:E284	R:R:T288	2.82	No	No	0	4	2
216	R:R:L286	R:R:R285	7.29	No	No	8	4	2
217	R:R:S290	R:R:Y287	5.09	No	Yes	0	5	4
218	R:R:V291	R:R:Y287	3.79	No	Yes	0	4	4
219	R:R:F293	R:R:V292	2.62	No	No	0	7	5
220	R:R:L294	R:R:S297	3	No	No	0	6	8
221	R:R:D304	R:R:N300	5.39	No	Yes	0	9	9
222	R:R:D304	R:R:G301	3.35	No	No	0	9	7
223	R:R:I307	R:R:L310	5.71	Yes	No	0	7	7
224	R:R:V309	R:R:Y308	3.79	No	No	0	6	9
225	R:R:T312	R:R:Y308	6.24	No	No	0	7	9
226	R:R:S315	R:R:V309	8.08	No	No	0	7	6
227	R:R:S315	R:R:T312	3.2	No	No	0	7	7
228	R:R:D313	R:R:R316	5.96	No	No	0	5	8
229	R:R:E318	R:R:R321	17.45	No	No	0	4	5
230	R:R:H323	R:R:V319	2.77	No	Yes	0	3	5
231	R:R:I322	R:R:R321	6.26	No	No	0	4	5
232	R:R:H323	R:R:K327	2.62	No	No	0	3	2
233	R:R:G325	R:R:K324	3.49	No	No	0	4	6
234	R:R:E328	R:R:G325	3.27	No	No	0	3	4
235	R:R:S330	R:R:W326	4.94	No	No	9	5	1
236	R:R:K332	R:R:W326	5.8	No	No	9	4	1
237	R:R:E328	R:R:W329	13.08	No	No	0	3	2
238	R:R:K332	R:R:S330	12.24	No	No	9	4	5
239	R:R:D334	R:R:R337	17.87	No	No	0	5	6
240	R:R:T336	R:R:T339	3.14	No	No	10	6	5
241	R:R:H340	R:R:T336	2.74	No	No	10	7	6
242	R:R:L338	R:R:S341	3	No	No	0	4	7
243	R:R:H340	R:R:T339	4.11	No	No	10	7	5
244	R:R:R342	R:R:T339	6.47	No	No	0	8	5
245	R:R:D182	R:R:E181	2.6	No	No	0	5	5
246	R:R:Q70	R:R:Q73	2.56	No	No	0	4	4
247	R:R:I160	R:R:R157	2.51	No	No	0	3	4
248	R:R:F223	R:R:I245	2.51	Yes	No	0	4	4
249	R:R:T298	R:R:Y49	2.5	No	Yes	0	7	8
250	R:R:K327	R:R:W326	2.32	No	No	0	2	1
251	R:R:F167	R:R:Y120	2.06	No	Yes	0	9	5
252	R:R:G56	R:R:P58	2.03	No	No	0	8	4
253	R:R:G93	R:R:P96	2.03	No	Yes	0	4	9
254	R:R:A256	R:R:P257	1.87	No	No	0	4	9
255	R:R:G207	R:R:V206	1.84	No	No	0	6	4
256	R:R:A119	R:R:C186	1.81	No	No	0	6	9
257	R:R:A64	R:R:A85	1.79	No	No	0	7	8
258	R:R:G111	R:R:L110	1.71	No	No	0	8	6
259	R:R:G111	R:R:L112	1.71	No	No	0	8	3
260	R:R:A234	R:R:S233	1.71	No	No	0	4	3
261	R:R:A311	R:R:S243	1.71	No	No	0	5	7
262	R:R:C254	R:R:V253	1.71	No	No	0	8	5
263	R:R:A78	R:R:V71	1.7	No	No	0	6	5
264	R:R:A159	R:R:V79	1.7	No	No	0	7	6
265	R:R:A289	R:R:V261	1.7	No	Yes	0	6	5
266	R:R:C138	R:R:T218	1.69	No	No	0	6	6
267	R:R:A51	R:R:T54	1.68	No	No	0	5	4
268	R:R:A202	R:R:T205	1.68	No	No	0	3	4
269	R:R:A311	R:R:T312	1.68	No	No	0	5	7
270	R:R:E88	R:R:G301	1.64	No	No	0	9	7
271	R:R:L95	R:R:P96	1.64	No	Yes	0	8	9
272	R:R:S194	R:R:S270	1.63	No	No	0	1	3
273	R:R:S225	R:R:V145	1.62	No	No	0	4	7
274	R:R:A303	R:R:I306	1.62	No	No	0	6	5
275	R:R:A303	R:R:I307	1.62	No	Yes	0	6	7
276	R:R:S315	R:R:V319	1.62	No	Yes	0	7	5
277	R:R:A234	R:R:K237	1.61	No	No	0	4	6
278	R:R:V173	R:R:V206	1.6	No	No	0	5	4
279	R:R:V249	R:R:V253	1.6	No	No	0	4	5
280	R:R:V261	R:R:V264	1.6	Yes	No	0	5	4
281	R:R:S341	R:R:T344	1.6	No	No	0	7	8
282	R:R:C61	R:R:L89	1.59	No	Yes	0	4	7
283	R:R:T63	R:R:V309	1.59	No	No	0	8	6
284	R:R:G171	R:R:H174	1.59	No	Yes	0	3	6
285	R:R:C254	R:R:L296	1.59	No	No	0	8	8
286	R:R:T333	R:R:V335	1.59	No	No	0	5	4
287	R:R:T336	R:R:V335	1.59	No	No	0	6	4
288	R:R:A67	R:R:L81	1.58	No	No	0	6	7
289	R:R:A67	R:R:L82	1.58	No	No	0	6	5
290	R:R:A114	R:R:L110	1.58	No	No	0	5	6
291	R:R:I126	R:R:S129	1.55	No	No	0	7	9
292	R:R:I130	R:R:S129	1.55	Yes	No	0	7	9
293	R:R:I160	R:R:S163	1.55	No	No	0	3	6
294	R:R:I210	R:R:S213	1.55	No	No	6	5	2
295	R:R:I214	R:R:S213	1.55	No	No	6	6	2
296	R:R:I43	R:R:V44	1.54	No	No	0	4	4
297	R:R:I121	R:R:V117	1.54	No	No	0	4	4
298	R:R:I307	R:R:V247	1.54	Yes	No	0	7	8
299	R:R:A235	R:R:Q236	1.52	No	No	0	3	5
300	R:R:K265	R:R:V261	1.52	Yes	Yes	0	5	5
301	R:R:G274	R:R:R273	1.5	No	No	0	3	1
302	R:R:L45	R:R:V48	1.49	Yes	No	0	6	5
303	R:R:L62	R:R:V319	1.49	No	Yes	0	5	5
304	R:R:L66	R:R:V319	1.49	No	Yes	0	6	5
305	R:R:L169	R:R:V173	1.49	No	No	0	4	5
306	R:R:L55	R:R:T54	1.47	No	No	0	5	4
307	R:R:A216	R:R:H220	1.46	No	No	0	4	4
308	R:R:G198	R:R:Y201	1.45	No	No	0	3	4
309	R:R:E39	R:R:S37	1.44	No	No	0	3	5
310	R:R:K324	R:R:K327	1.44	No	No	0	6	2
311	R:R:P176	R:R:Y175	1.39	No	No	0	8	4
312	R:R:D334	R:R:M331	1.39	No	No	0	5	4
313	R:R:L212	R:R:L252	1.38	No	No	0	5	5
314	R:R:L260	R:R:L263	1.38	No	No	0	5	5
315	R:R:I43	R:R:Q105	1.37	No	Yes	0	4	4
316	R:R:H242	R:R:I245	1.33	No	No	0	5	4
317	R:R:R103	R:R:V46	1.31	No	No	4	4	6
318	R:R:R103	R:R:V99	1.31	No	No	4	4	7
319	R:R:R285	R:R:T288	1.29	No	No	0	2	2
320	R:R:F223	R:R:K227	1.24	Yes	No	0	4	4
321	R:R:K227	R:R:R224	1.24	No	No	0	4	4
322	R:R:L338	R:R:R342	1.21	No	No	0	4	8
323	R:R:Q317	R:R:R316	1.17	No	No	0	4	8
324	R:R:M331	R:R:W329	1.16	No	No	0	4	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13.6471	7	1	0
2	R:R:F38	5.21	4	1	2
3	R:R:R42	7.85	6	1	4
4	R:R:L45	3.375	4	5	6
5	R:R:Y49	5.8625	4	5	8
6	R:R:N60	7.3825	4	0	9
7	R:R:Y80	4.13	5	2	7
8	R:R:L89	5.804	5	0	7
9	R:R:Y91	5.4125	4	3	7
10	R:R:P96	3.69	4	0	9
11	R:R:W98	5.3775	4	3	6
12	R:R:Q105	4.778	5	1	4
13	R:R:H106	10.632	5	1	5
14	R:R:Y120	6.61	4	0	5
15	R:R:F122	6.2	4	0	6
16	R:R:F123	6.0925	4	0	5
17	R:R:I130	4.532	5	1	7
18	R:R:F132	4.13714	7	2	7
19	R:R:I166	4.865	4	2	6
20	R:R:H174	8.1825	4	0	6
21	R:R:F187	4.886	5	1	4
22	R:R:D188	9.9425	4	1	5
23	R:R:M189	3.565	4	0	4
24	R:R:L190	6.724	5	1	4
25	R:R:Y200	8.16	6	1	5
26	R:R:R203	4.5975	4	1	5
27	R:R:F208	12.115	4	1	8
28	R:R:I215	3.734	5	0	8
29	R:R:N219	4.015	4	0	9
30	R:R:R221	8.3475	4	0	4
31	R:R:F223	6.01	4	0	4
32	R:R:F251	5.9275	4	1	9
33	R:R:F255	7.4275	4	1	9
34	R:R:Y258	7.2975	4	1	7
35	R:R:H259	10.805	4	1	8
36	R:R:V261	2.1875	4	0	5
37	R:R:K265	3.426	5	1	5
38	R:R:E283	7.36	4	0	3
39	R:R:Y287	7.77429	7	1	4
40	R:R:N300	9.51	4	0	9
41	R:R:I307	3.69	4	0	7
42	R:R:V319	1.8425	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H106	26.678	17.33	Yes	Yes	1	0	5
2	R:R:F38	R:R:H106	11.3945	5.66	Yes	Yes	1	2	5
3	L:L:?1	R:R:Y287	29.2042	19.31	Yes	Yes	1	0	4
4	R:R:F38	R:R:Y287	21.5478	5.16	Yes	Yes	1	2	4
5	R:R:H106	R:R:R42	11.4578	16.93	Yes	Yes	1	5	4
6	R:R:R42	R:R:Y287	22.3363	6.17	Yes	Yes	1	4	4
7	R:R:F38	R:R:Q105	29.3551	4.68	Yes	Yes	1	2	4
8	R:R:Q105	R:R:R42	37.7707	7.01	Yes	Yes	1	4	4
9	R:R:E39	R:R:Q105	20.8275	3.82	No	Yes	0	3	4
10	R:R:E39	R:R:E40	10.4308	3.81	No	No	0	3	3
11	L:L:?1	R:R:T185	12.5237	11.04	Yes	No	0	0	3
12	R:R:F187	R:R:T185	10.5476	6.49	Yes	No	0	4	3
13	R:R:I43	R:R:Q105	26.0112	1.37	No	Yes	0	4	4
14	R:R:I43	R:R:R103	15.634	5.01	No	No	0	4	4
15	R:R:V291	R:R:Y287	14.4463	3.79	No	Yes	0	4	4
16	R:R:L45	R:R:V291	14.5437	2.98	Yes	No	0	6	4
17	R:R:L45	R:R:Y49	14.9525	5.86	Yes	Yes	5	6	8
18	L:L:?1	R:R:D188	86.9603	5.08	Yes	Yes	1	0	5
19	R:R:D188	R:R:Y200	87.7683	11.49	Yes	Yes	1	5	5
20	R:R:F123	R:R:Y200	63.5483	8.25	Yes	Yes	0	5	5
21	R:R:F122	R:R:F123	53.8574	6.43	Yes	Yes	0	6	5
22	R:R:F122	R:R:L294	22.789	4.87	Yes	No	0	6	6
23	R:R:L294	R:R:Y49	17.4106	7.03	No	Yes	0	6	8
24	R:R:F122	R:R:Y91	42.4775	7.22	Yes	Yes	0	6	7
25	R:R:L95	R:R:Y91	39.1482	5.86	No	Yes	3	8	7
26	R:R:L95	R:R:P96	50.3626	1.64	No	Yes	0	8	9
27	R:R:G93	R:R:P96	46.4201	2.03	No	Yes	0	4	9
28	R:R:G93	R:R:L89	45.3784	3.42	No	Yes	0	4	7
29	R:R:Y200	R:R:Y258	56.588	2.98	Yes	Yes	1	5	7
30	R:R:H259	R:R:Y258	67.7148	4.36	Yes	Yes	1	8	7
31	R:R:H259	R:R:I130	76.6026	2.65	Yes	Yes	1	8	7
32	R:R:F255	R:R:I130	13.2879	6.28	Yes	Yes	1	9	7
33	R:R:F255	R:R:N300	36.2035	13.29	Yes	Yes	0	9	9
34	R:R:I250	R:R:N300	10.3188	9.91	No	Yes	0	6	9
35	R:R:D304	R:R:N300	25.8262	5.39	No	Yes	0	9	9
36	R:R:D304	R:R:G301	24.9258	3.35	No	No	0	9	7
37	R:R:E88	R:R:G301	24.1957	1.64	No	No	0	9	7
38	R:R:L89	R:R:N60	42.458	15.1	Yes	Yes	0	7	9
39	R:R:N60	R:R:P305	56.8995	3.26	Yes	No	0	9	9
40	R:R:P305	R:R:T63	55.6875	6.99	No	No	0	9	8
41	R:R:T63	R:R:V309	54.5291	1.59	No	No	0	8	6
42	R:R:S315	R:R:V309	41.3629	8.08	No	No	0	7	6
43	R:R:S315	R:R:V319	39.7566	1.62	No	Yes	0	7	5
44	R:R:L66	R:R:V319	13.726	1.49	No	Yes	0	6	5
45	R:R:I322	R:R:L66	11.7936	2.85	No	No	0	4	6
46	R:R:F123	R:R:H174	78.6323	4.53	Yes	Yes	0	5	6
47	R:R:H174	R:R:Y120	76.4955	14.16	Yes	Yes	0	6	5
48	R:R:C124	R:R:Y120	63.4607	5.38	No	Yes	0	5	5
49	R:R:C124	R:R:V170	61.3677	5.12	No	No	0	5	7
50	R:R:V128	R:R:V170	59.5279	4.81	No	No	0	7	7
51	R:R:F132	R:R:V128	58.6809	2.62	Yes	No	0	7	7
52	R:R:F132	R:R:Y80	32.5821	4.13	Yes	Yes	2	7	7
53	R:R:A159	R:R:Y80	28.6152	2.67	No	Yes	0	7	7
54	R:R:A159	R:R:V76	24.8868	5.09	No	No	0	7	6
55	R:R:R154	R:R:V76	23.0518	7.85	No	No	0	7	6
56	R:R:N75	R:R:R154	21.2899	9.64	No	No	0	7	7
57	R:R:A78	R:R:N75	15.3517	4.69	No	No	0	6	7
58	R:R:V309	R:R:Y308	20.5792	3.79	No	No	0	6	9
59	R:R:L81	R:R:Y308	19.5473	7.03	No	No	0	7	9
60	R:R:A67	R:R:L81	18.0677	1.58	No	No	0	6	7
61	R:R:A67	R:R:L82	16.6026	1.58	No	No	0	6	5
62	R:R:A78	R:R:V71	14.4609	1.7	No	No	0	6	5
63	R:R:L82	R:R:V71	14.5193	5.96	No	No	0	5	5
64	R:R:F132	R:R:S163	17.7123	2.64	Yes	No	0	7	6
65	R:R:I160	R:R:S163	15.2105	1.55	No	No	0	3	6
66	R:R:I160	R:R:R157	12.699	2.51	No	No	0	3	4
67	R:R:F187	R:R:W108	28.0409	4.01	Yes	No	0	4	9
68	R:R:C115	R:R:W108	28.6736	3.92	No	No	0	9	9
69	R:R:C115	R:R:T118	35.7703	3.38	No	No	0	9	5
70	R:R:T118	R:R:W98	13.9499	4.85	No	Yes	3	5	6
71	R:R:Q105	R:R:R107	15.634	7.01	Yes	No	0	4	5
72	R:R:I102	R:R:R107	10.4308	3.76	No	No	0	6	5
73	R:R:L112	R:R:W108	13.3074	5.69	No	No	0	3	9
74	R:R:G111	R:R:L112	10.1582	1.71	No	No	0	8	3
75	R:R:M189	R:R:T185	14.3247	3.01	Yes	No	0	4	3
76	R:R:I196	R:R:M189	10.1533	4.37	No	Yes	0	5	4
77	L:L:?1	R:R:Q191	23.7381	23.92	Yes	No	0	0	4
78	R:R:F122	R:R:I126	18.3256	6.28	Yes	No	0	6	7
79	R:R:F123	R:R:Y127	12.8158	5.16	Yes	No	0	5	8
80	R:R:I130	R:R:P211	16.0428	3.39	Yes	No	0	7	9
81	R:R:F251	R:R:I130	69.5595	8.79	Yes	Yes	1	9	7
82	R:R:F251	R:R:I215	100	3.77	Yes	Yes	0	9	8
83	R:R:I215	R:R:S137	46.1718	3.1	Yes	No	0	8	9
84	R:R:S137	R:R:T218	43.816	4.8	No	No	0	9	6
85	R:R:F141	R:R:T218	39.1239	5.19	No	No	0	8	6
86	R:R:F141	R:R:V145	25.4514	2.62	No	No	0	8	7
87	R:R:F141	R:R:R221	13.4242	5.34	No	Yes	0	8	4
88	R:R:V145	R:R:Y146	17.9168	10.09	No	No	0	7	6
89	R:R:V142	R:R:Y146	15.3857	3.79	No	No	0	5	6
90	R:R:R203	R:R:Y200	18.2672	5.14	Yes	Yes	1	5	5
91	R:R:R203	R:R:Y199	10.5963	5.14	Yes	No	1	5	4
92	R:R:D182	R:R:M189	10.129	4.16	No	Yes	0	5	4
93	R:R:F269	R:R:Q191	15.8968	4.68	No	No	0	4	4
94	L:L:?1	R:R:E283	29.3453	10.91	Yes	Yes	0	0	3
95	R:R:E283	R:R:F269	15.0207	4.66	Yes	No	0	3	4
96	R:R:F269	R:R:R273	26.6683	7.48	No	No	0	4	1
97	R:R:R273	R:R:S194	20.0584	13.18	No	No	0	1	1
98	R:R:K265	R:R:L262	20.7593	2.82	Yes	No	1	5	6
99	R:R:I215	R:R:N219	48.625	4.25	Yes	Yes	0	8	9
100	R:R:A244	R:R:N219	41.4553	3.13	No	Yes	0	6	9
101	R:R:A244	R:R:F223	39.119	4.16	No	Yes	0	6	4
102	R:R:F223	R:R:K241	25.5001	16.13	Yes	No	0	4	5
103	R:R:I226	R:R:K241	20.4381	5.82	No	No	7	8	5
104	R:R:I226	R:R:L232	17.9508	5.71	No	No	0	8	2
105	R:R:L232	R:R:Q236	12.8693	3.99	No	No	0	2	5
106	R:R:L294	R:R:S297	31.4675	3	No	No	0	6	8
107	R:R:K265	R:R:V261	19.5522	1.52	Yes	Yes	0	5	5
108	R:R:F293	R:R:V261	11.229	3.93	No	Yes	0	7	5
109	R:R:S290	R:R:Y287	13.8233	5.09	No	Yes	0	5	4
110	R:R:S194	R:R:S270	16.7389	1.63	No	No	0	1	3
111	R:R:S270	R:R:Y271	13.4096	3.82	No	No	0	3	2
112	R:R:E283	R:R:M279	12.5675	10.83	Yes	No	0	3	4
113	R:R:L282	R:R:M279	10.8007	2.83	No	No	0	1	4
114	R:R:H323	R:R:V319	23.2417	2.77	No	Yes	0	3	5
115	R:R:H323	R:R:K327	21.358	2.62	No	No	0	3	2
116	R:R:K324	R:R:K327	13.726	1.44	No	No	0	6	2
117	R:R:G325	R:R:K324	11.7936	3.49	No	No	0	4	6
118	R:R:I126	R:R:S129	17.1526	1.55	No	No	0	7	9
119	R:R:I130	R:R:S129	17.3083	1.55	Yes	No	0	7	9
120	R:R:T118	R:R:Y91	22.6624	3.75	No	Yes	3	5	7
121	R:R:L95	R:R:W98	12.5919	4.56	No	Yes	3	8	6
122	R:R:F255	R:R:S297	30.8786	2.64	Yes	No	0	9	8
123	R:R:E88	R:R:N60	23.9961	5.26	No	Yes	0	9	9
124	R:R:K265	R:R:S290	15.0207	3.06	Yes	No	0	5	5
125	R:R:F187	R:R:R42	10.2409	3.21	Yes	Yes	1	4	4
126	R:R:L262	R:R:Y258	15.7897	18.76	No	Yes	1	6	7
127	R:R:F251	R:R:F255	36.8849	7.5	Yes	Yes	1	9	9
128	R:R:F208	R:R:Y127	11.8618	6.19	Yes	No	0	8	8
129	R:R:F208	R:R:H259	10.8591	31.68	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:H106	17.33	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E184	7.94	1	Yes	No	0	4	0	1
L:L:?1	R:R:T185	11.04	1	Yes	No	0	3	0	1
L:L:?1	R:R:D188	5.08	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:Q191	23.92	1	Yes	No	0	4	0	1
L:L:?1	R:R:E283	10.91	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y287	19.31	1	Yes	Yes	0	4	0	1
R:R:F38	R:R:R42	5.34	1	Yes	Yes	2	4	2	2
R:R:F38	R:R:H106	5.66	1	Yes	Yes	2	5	2	1
R:R:F38	R:R:Y287	5.16	1	Yes	Yes	2	4	2	1
R:R:H106	R:R:R42	16.93	1	Yes	Yes	5	4	1	2
R:R:F187	R:R:R42	3.21	1	Yes	Yes	4	4	2	2
R:R:R42	R:R:Y287	6.17	1	Yes	Yes	4	4	2	1
R:R:F187	R:R:H106	4.53	1	Yes	Yes	4	5	2	1
R:R:H106	R:R:Y287	8.71	1	Yes	Yes	5	4	1	1
R:R:F187	R:R:T185	6.49	1	Yes	No	4	3	2	1
R:R:M189	R:R:T185	3.01	0	Yes	No	4	3	2	1
R:R:F187	R:R:Y287	6.19	1	Yes	Yes	4	4	2	1
R:R:D188	R:R:L190	16.29	1	Yes	Yes	5	4	1	2
R:R:D188	R:R:Y200	11.49	1	Yes	Yes	5	5	1	2
R:R:D188	R:R:K265	6.91	1	Yes	Yes	5	5	1	2
R:R:M189	R:R:Q191	2.72	0	Yes	No	4	4	2	1
R:R:L190	R:R:Y200	8.21	1	Yes	Yes	4	5	2	2
R:R:K265	R:R:L190	2.82	1	Yes	Yes	5	4	2	2
R:R:F269	R:R:Q191	4.68	0	No	No	4	4	2	1
R:R:K265	R:R:S290	3.06	1	Yes	No	5	5	2	2
R:R:E283	R:R:F269	4.66	0	Yes	No	3	4	1	2
R:R:E283	R:R:M279	10.83	0	Yes	No	3	4	1	2
R:R:C280	R:R:E283	3.04	0	No	Yes	8	3	2	1
R:R:S290	R:R:Y287	5.09	0	No	Yes	5	4	2	1
R:R:V291	R:R:Y287	3.79	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HQM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.62
Number of Linked Nodes	284
Number of Links	324
Number of Hubs	42
Number of Links mediated by Hubs	147
Number of Communities	10
Number of Nodes involved in Communities	51
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	130
Number Of Links MetaPath	129
Number of Shortest Paths	67246
Length Of Smallest Path	3
Average Path Length	14.255
Length of Longest Path	33
Minimum Path Strength	1.24
Average Path Strength	5.7348
Maximum Path Strength	21.615
Minimum Path Correlation	0.7
Average Path Correlation	0.969142
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	68.0967
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.8224
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • mitotic cell cycle process • cell cycle phase transition • cell cycle • G1/S transition of mitotic cell cycle • cell cycle G1/S phase transition • mitotic cell cycle • mitotic cell cycle phase transition • cell cycle process • regulation of cell cycle phase transition • regulation of cellular process • G2/M transition of mitotic cell cycle • negative regulation of biological process • negative regulation of cell cycle • negative regulation of mitotic cell cycle • regulation of mitotic cell cycle • negative regulation of cellular process • negative regulation of cell cycle phase transition • regulation of cell cycle • cell cycle G2/M phase transition • regulation of biological process • negative regulation of mitotic cell cycle phase transition • regulation of G2/M transition of mitotic cell cycle • regulation of cell cycle process • biological regulation • regulation of cell cycle G2/M phase transition • negative regulation of cell cycle process • regulation of mitotic cell cycle phase transition • negative regulation of cell cycle G2/M phase transition • negative regulation of G2/M transition of mitotic cell cycle • periplasmic space • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	140
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	140
Name	N-hexadecanoylglycine
Synonyms	N-Palmitoyl glycine
Identifier
Formula	C18 H35 N O3
Molecular Weight	313.475
SMILES
PubChem	151008
Formal Charge	0
Total Atoms	57
Total Chiral Atoms	0
Total Bonds	56
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UNW8
Sequence	>8HQM_nogp_Chain_R S F E E S R I V L V V V Y S A V C T L G V P A N C L T A W L A L L Q V L Q G N V L A V Y L L C L A L C E L L Y T G T L P L W V I Y I R N Q H R W T L G L L A C K V T A Y I F F C N I Y V S I L F L C C I S C D R F V A V V Y A L E S R G R R R R R T A I L I S A C I F I L V G I V H Y P V F Q T E D K E T C F D M L Q M D S R I A G Y Y Y A R F T V G F A I P L S I I A F T N H R I F R S I K Q S M G L S A A Q K A K V K H S A I A V V V I F L V C F A P Y H L V L L V K A A A F S Y Y R G A M C G L E E R L Y T A S V V F L C L S T V N G V A D P I I Y V L A T D H S R Q E V S R I H K G W K E W S M K T D V T R L T H S R D T E E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HQE	A	Orphan	Orphan	GPR132	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQE (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	-	-		2.97	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQM	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-	Gi1/β1/γ2	2.95	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQM (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-		2.95	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQN	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-	Gi1/β1/γ2	3	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HQN (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-		3	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HVI	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-	Gi1/β1/γ2	3.04	2023-10-11	doi.org/10.1038/s42255-023-00899-4
	8HVI (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-		3.04	2023-10-11	doi.org/10.1038/s42255-023-00899-4

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