Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 9.7391010
2R:R:Y49 6.93408
3R:R:Y80 3.8325407
4R:R:L89 4.364507
5R:R:Y91 8.21833627
6R:R:W98 9.0825426
7R:R:Q105 5.6275404
8R:R:F122 8.4275406
9R:R:F123 9.1625415
10R:R:I130 2.27417
11R:R:F132 2.6507
12R:R:H174 6.385416
13R:R:F187 13.0725444
14R:R:L190 7.2925414
15R:R:Y200 10.78415
16R:R:R203 6.292515
17R:R:F204 5.8525415
18R:R:F208 12.7525418
19R:R:N219 5.0375409
20R:R:K241 6.46405
21R:R:F255 5.29519
22R:R:Y258 6.83417
23R:R:F269 8.1225414
24R:R:Y287 7.1225404
25R:R:F293 4.736507
26R:R:N300 7.975419
27R:R:P305 7.37439
28R:R:R321 8.405405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:F123 68.191920.72YesYes105
2R:R:F122 R:R:F123 72.7417.5YesYes065
3R:R:F122 R:R:L294 37.43233.65YesNo066
4R:R:L294 R:R:Y49 91.41715.86NoYes068
5R:R:L45 R:R:Y49 86.62825.86NoYes068
6R:R:L45 R:R:V291 83.92712.98NoNo064
7R:R:V291 R:R:Y287 82.555.05NoYes044
8R:R:F38 R:R:Y287 42.18579.28NoYes024
9R:R:F38 R:R:Q105 40.3824.68NoYes024
10R:R:Q105 R:R:R42 19.59133.5YesNo044
11R:R:R42 R:R:V46 17.05026.54NoNo046
12R:R:D188 R:R:Y287 42.185710.34NoYes054
13R:R:I43 R:R:V46 10.71521.54NoNo046
14R:R:F122 R:R:Y91 49.80917.54YesYes067
15R:R:L95 R:R:Y91 47.463311.72NoYes087
16R:R:L95 R:R:P96 1004.93NoNo089
17R:R:C53 R:R:P96 12.563311.3NoNo069
18R:R:C53 R:R:V57 11.23061.71NoNo066
19R:R:P58 R:R:V57 11.18615.3NoNo046
20R:R:G93 R:R:P96 86.14842.03NoNo049
21R:R:G93 R:R:L89 84.81561.71NoYes047
22R:R:L89 R:R:N60 83.26089.61YesNo079
23R:R:N60 R:R:P305 77.947616.29NoYes399
24R:R:P305 R:R:T63 24.03385.25YesNo098
25R:R:T63 R:R:Y308 17.68993.75NoNo089
26R:R:D304 R:R:P305 58.73833.22NoYes099
27R:R:D304 R:R:L84 56.96146.79NoNo099
28R:R:F132 R:R:L84 53.35412.44YesNo079
29R:R:C135 R:R:F132 38.21412.79NoYes067
30R:R:C135 R:R:Y80 36.24174.03NoYes067
31R:R:A159 R:R:Y80 19.82232.67NoYes077
32R:R:A159 R:R:V79 17.68991.7NoNo076
33R:R:I160 R:R:V79 15.53981.54NoNo036
34R:R:C83 R:R:I160 13.37181.64NoNo093
35R:R:C83 R:R:L82 11.18611.59NoNo095
36R:R:I121 R:R:Y91 12.99874.84NoYes047
37R:R:Q105 R:R:R107 16.161710.51YesNo045
38R:R:I102 R:R:R107 13.90495.01NoNo065
39R:R:D188 R:R:F187 36.79255.97NoYes454
40R:R:F187 R:R:W108 32.64337.02YesNo049
41R:R:L112 R:R:W108 15.29999.11NoNo039
42R:R:C115 R:R:W108 15.29999.14NoNo099
43R:R:I102 R:R:T109 11.63041.52NoNo064
44R:R:K116 R:R:L112 13.16755.64NoNo083
45R:R:C115 R:R:K116 13.16753.23NoNo098
46R:R:E181 R:R:K116 21.98132.7NoNo058
47L:L:?1 R:R:Y127 36.91694.43YesNo008
48R:R:F208 R:R:Y127 36.62378.25YesNo088
49R:R:F208 R:R:I130 44.58462.51YesYes187
50R:R:F251 R:R:I130 32.73212.51NoYes197
51R:R:F251 R:R:L252 88.0322.44NoNo095
52R:R:L252 R:R:V248 85.12.98NoNo056
53R:R:I215 R:R:V248 36.33943.07NoNo086
54R:R:C134 R:R:I215 11.23064.91NoNo078
55R:R:I215 R:R:S137 24.13153.1NoNo089
56R:R:S137 R:R:T218 22.02583.2NoNo096
57R:R:F141 R:R:T218 19.90233.89NoNo086
58R:R:F141 R:R:Y146 15.53984.13NoNo586
59R:R:V142 R:R:Y146 13.42513.79NoNo056
60R:R:N219 R:R:V248 55.40652.96YesNo096
61R:R:I222 R:R:N219 19.04932.83NoYes089
62L:L:?1 R:R:R203 12.572210.72YesYes105
63R:R:E181 R:R:F178 17.61881.17NoNo054
64R:R:F178 R:R:Q179 13.23868.2NoNo044
65L:L:?1 R:R:L190 22.32796.98YesYes104
66R:R:F269 R:R:L190 10.33324.87YesYes144
67R:R:F269 R:R:S194 16.543810.57YesNo041
68R:R:Q191 R:R:S194 18.51624.33NoNo041
69R:R:M189 R:R:Q191 12.3592.72NoNo044
70L:L:?1 R:R:K265 22.32799.77YesNo005
71R:R:F269 R:R:K265 10.27998.69YesNo045
72R:R:A197 R:R:K265 10.25323.21NoNo045
73L:L:?1 R:R:Y258 18.79162.95YesYes107
74R:R:F204 R:R:F208 12.78548.57YesYes158
75R:R:F223 R:R:N219 27.43679.67NoYes049
76R:R:F223 R:R:H220 13.26522.26NoNo044
77R:R:I222 R:R:K241 12.91872.91NoYes085
78R:R:F223 R:R:K241 13.131911.17NoYes045
79R:R:I226 R:R:K241 17.19248.72NoYes085
80R:R:F255 R:R:I130 13.67392.51YesYes197
81R:R:F255 R:R:N300 11.141712.08YesYes199
82R:R:L294 R:R:S297 71.67484.5NoNo068
83R:R:F293 R:R:Y258 18.89835.16YesYes077
84L:L:?1 R:R:L286 27.36566.1YesNo004
85R:R:L282 R:R:L286 17.19242.77NoNo014
86R:R:V309 R:R:Y308 13.37183.79NoNo069
87R:R:S315 R:R:V309 11.18613.23NoNo076
88R:R:F255 R:R:S297 70.67082.64YesNo098
89R:R:F251 R:R:F255 56.69486.43NoYes199
90R:R:L95 R:R:Y49 64.68243.52NoYes088
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:F123 20.72 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y127 4.43 1 Yes No 0 8 0 1
L:L:?1 R:R:H174 12.96 1 Yes Yes 0 6 0 1
L:L:?1 R:R:V177 2.82 1 Yes No 0 5 0 1
L:L:?1 R:R:L190 6.98 1 Yes Yes 0 4 0 1
L:L:?1 R:R:Y200 19.94 1 Yes Yes 0 5 0 1
L:L:?1 R:R:R203 10.72 1 Yes Yes 0 5 0 1
L:L:?1 R:R:Y258 2.95 1 Yes Yes 0 7 0 1
L:L:?1 R:R:K265 9.77 1 Yes No 0 5 0 1
L:L:?1 R:R:L286 6.1 1 Yes No 0 4 0 1
R:R:A119 R:R:F123 2.77 0 No Yes 6 5 2 1
R:R:F122 R:R:F123 7.5 0 Yes Yes 6 5 2 1
R:R:F123 R:R:H174 5.66 1 Yes Yes 5 6 1 1
R:R:V170 R:R:Y127 5.05 0 No No 7 8 2 1
R:R:F208 R:R:Y127 8.25 1 Yes No 8 8 2 1
R:R:H174 R:R:V170 2.77 1 Yes No 6 7 1 2
R:R:R203 R:R:V173 3.92 1 Yes No 5 5 1 2
R:R:H174 R:R:V177 4.15 1 Yes No 6 5 1 1
R:R:R203 R:R:V177 6.54 1 Yes No 5 5 1 1
R:R:F269 R:R:L190 4.87 1 Yes Yes 4 4 2 1
R:R:D275 R:R:L190 4.07 1 No Yes 2 4 2 1
R:R:E283 R:R:L190 13.25 0 No Yes 3 4 2 1
R:R:A197 R:R:K265 3.21 0 No No 4 5 2 1
R:R:R203 R:R:Y199 5.14 1 Yes No 5 4 1 2
R:R:R203 R:R:Y200 5.14 1 Yes Yes 5 5 1 1
R:R:Y200 R:R:Y258 3.97 1 Yes Yes 5 7 1 1
R:R:L262 R:R:Y200 14.07 1 No Yes 6 5 2 1
R:R:L262 R:R:Y258 15.24 1 No Yes 6 7 2 1
R:R:F293 R:R:Y258 5.16 0 Yes Yes 7 7 2 1
R:R:F269 R:R:K265 8.69 1 Yes No 4 5 2 1
R:R:D275 R:R:F269 8.36 1 No Yes 2 4 2 2
R:R:L282 R:R:L286 2.77 0 No No 1 4 2 1
R:R:L286 R:R:R285 8.5 0 No No 4 2 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8HQN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.44
Number of Linked Nodes 277
Number of Links 290
Number of Hubs 28
Number of Links mediated by Hubs 107
Number of Communities 7
Number of Nodes involved in Communities 38
Number of Links involved in Communities 48
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 31578
Length Of Smallest Path 3
Average Path Length 14.0013
Length of Longest Path 35
Minimum Path Strength 1.485
Average Path Strength 5.76397
Maximum Path Strength 20.33
Minimum Path Correlation 0.7
Average Path Correlation 0.967162
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 6.25
Average % Of Corr. Nodes 66.7736
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 34.0897
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • tetrapyrrole binding   • heme binding   • electron transfer activity   • cation binding   • transition metal ion binding   • iron ion binding   • ion binding   • metal ion binding   • small molecule binding   • mitotic cell cycle process   • cell cycle phase transition   • cell cycle   • G1/S transition of mitotic cell cycle   • cell cycle G1/S phase transition   • mitotic cell cycle   • mitotic cell cycle phase transition   • cell cycle process   • regulation of cell cycle phase transition   • G2/M transition of mitotic cell cycle   • negative regulation of biological process   • negative regulation of cell cycle   • negative regulation of mitotic cell cycle   • regulation of mitotic cell cycle   • negative regulation of cellular process   • negative regulation of cell cycle phase transition   • regulation of cell cycle   • cell cycle G2/M phase transition   • negative regulation of mitotic cell cycle phase transition   • regulation of G2/M transition of mitotic cell cycle   • regulation of cell cycle process   • regulation of cell cycle G2/M phase transition   • negative regulation of cell cycle process   • regulation of mitotic cell cycle phase transition   • negative regulation of cell cycle G2/M phase transition   • negative regulation of G2/M transition of mitotic cell cycle   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • periplasmic space   • D2 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • phosphorus-oxygen lyase activity   • enzyme regulator activity   • cyclase regulator activity   • molecular function regulator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • catalytic activity   • adenylate cyclase activity   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • response to peptide hormone   • cell division   • leukocyte migration   • immune system process   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • positive regulation of biological process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • positive regulation of metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • positive regulation of cellular process   • regulation of biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • regulation of metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • cellular component organization   • cellular component organization or biogenesis   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • protein localization   • positive regulation of protein localization to cell periphery   • regulation of localization   • protein localization to cell periphery   • cellular localization   • regulation of protein localization   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • localization   • regulation of cellular localization   • regulation of protein localization to cell cortex   • cellular macromolecule localization   • macromolecule localization   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • Golgi apparatus   • endomembrane system   • ciliary basal body
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain   • Ras-like P-loop GTPases
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code9HO
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code9HO
Name9(S)-HODE
Synonyms
  • (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
  • 9S-Hode
  • 9(S)-HODE
  • alpha-Dimorphecolic acid
Identifier
FormulaC18 H32 O3
Molecular Weight296.445
SMILES
PubChem5312830
Formal Charge0
Total Atoms53
Total Chiral Atoms1
Total Bonds52
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9UNW8
Sequence
>8HQN_nogp_Chain_R
SFEESRIVL VVVYSAVCT LGVPANCLT AWLALLQVL QGNVLAVYL 
LCLALCELL YTGTLPLWV IYIRNQHRW TLGLLACKV TAYIFFCNI 
YVSILFLCC ISCDRFVAV VYALESRGR RRRRTAILI SACIFILVG 
IVHYPVFQT EDKETCFDM LQMDSRIAG YYYARFTVG FAIPLSIIA 
FTNHRIFRS IKQSMGLSA AQKAKVKHS AIAVVVIFL VCFAPYHLV 
LLVKAAAFS YYRGDRNAM CGLEERLYT ASVVFLCLS TVNGVADPI 
IYVLATDHS RQEVSRIHK GWKEWSMKT DVTRLTHSR DTEE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HVIAOrphanOrphanGPR132Homo sapiensNOX-6-7-Gi1/β1/γ23.042023-10-110.1038/s42255-023-00899-4
8HVI (No Gprot) AOrphanOrphanGPR132Homo sapiensNOX-6-7-3.042023-10-110.1038/s42255-023-00899-4
8HQNAOrphanOrphanGPR132Homo sapiens9-S-HODE-Gi1/β1/γ232023-10-110.1038/s42255-023-00899-4
8HQN (No Gprot) AOrphanOrphanGPR132Homo sapiens9-S-HODE-32023-10-110.1038/s42255-023-00899-4
8HQMAOrphanOrphanGPR132Homo sapiensNPGLY-Gi1/β1/γ22.952023-10-110.1038/s42255-023-00899-4
8HQM (No Gprot) AOrphanOrphanGPR132Homo sapiensNPGLY-2.952023-10-110.1038/s42255-023-00899-4
8HQEAOrphanOrphanGPR132Homo sapiens--Gi1/β1/γ22.972023-10-110.1038/s42255-023-00899-4
8HQE (No Gprot) AOrphanOrphanGPR132Homo sapiens--2.972023-10-110.1038/s42255-023-00899-4




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Download 8HQN_nogp.zip



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