psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N104	3.63	Yes	Yes	2	0	4
2	L:L:?1	R:R:Q105	2.35	Yes	No	0	0	4
3	L:L:?1	R:R:H106	10.2	Yes	Yes	2	0	5
4	L:L:?1	R:R:W108	10.04	Yes	Yes	2	0	9
5	L:L:?1	R:R:D188	8.37	Yes	No	2	0	5
6	L:L:?1	R:R:M189	6.23	Yes	No	2	0	4
7	L:L:?1	R:R:L190	4.88	Yes	No	2	0	4
8	L:L:?1	R:R:Q191	5.87	Yes	No	2	0	4
9	L:L:?1	R:R:Y287	44.43	Yes	No	2	0	4
10	R:R:E39	R:R:S41	10.06	No	No	0	3	4
11	R:R:R103	R:R:R42	13.86	Yes	No	0	4	4
12	R:R:L45	R:R:V291	2.98	No	No	0	6	4
13	R:R:L45	R:R:V292	4.47	No	No	0	6	5
14	R:R:C295	R:R:L45	3.17	No	No	0	5	6
15	R:R:V46	R:R:V99	3.21	Yes	No	0	6	7
16	R:R:I100	R:R:V46	3.07	No	Yes	0	3	6
17	R:R:R103	R:R:V46	2.62	Yes	Yes	0	4	6
18	R:R:C295	R:R:V48	1.71	No	No	0	5	5
19	R:R:L95	R:R:Y49	5.86	No	Yes	0	8	8
20	R:R:P96	R:R:Y49	18.08	No	Yes	0	9	8
21	R:R:V99	R:R:Y49	2.52	No	Yes	0	7	8
22	R:R:T298	R:R:Y49	6.24	No	Yes	0	7	8
23	R:R:I100	R:R:S50	3.1	No	No	0	3	5
24	R:R:V299	R:R:V52	4.81	No	No	0	5	7
25	R:R:C53	R:R:G93	1.96	No	No	6	6	4
26	R:R:C53	R:R:P96	5.65	No	No	6	6	9
27	R:R:A59	R:R:G56	1.95	No	No	0	7	8
28	R:R:G56	R:R:V302	1.84	No	No	0	8	7
29	R:R:P58	R:R:V57	1.77	No	No	0	4	6
30	R:R:E88	R:R:N60	14.46	Yes	Yes	1	9	9
31	R:R:N60	R:R:P305	3.26	Yes	No	1	9	9
32	R:R:P305	R:R:T63	8.74	No	No	0	9	8
33	R:R:L68	R:R:W65	6.83	No	No	0	3	3
34	R:R:L66	R:R:Q70	5.32	No	No	0	6	4
35	R:R:I322	R:R:L66	5.71	No	No	0	4	6
36	R:R:E318	R:R:Q70	3.82	No	No	0	4	4
37	R:R:G74	R:R:N75	3.39	No	No	7	5	7
38	R:R:A78	R:R:G74	1.95	No	No	7	6	5
39	R:R:L77	R:R:N75	12.36	No	No	0	7	7
40	R:R:A78	R:R:N75	3.13	No	No	7	6	7
41	R:R:R156	R:R:V76	7.85	No	No	0	3	6
42	R:R:L77	R:R:R140	7.29	No	No	0	7	9
43	R:R:C83	R:R:V79	1.71	No	No	0	9	6
44	R:R:C135	R:R:Y80	6.72	No	Yes	0	6	7
45	R:R:I136	R:R:Y80	3.63	No	Yes	0	8	7
46	R:R:A159	R:R:Y80	6.67	No	Yes	0	7	7
47	R:R:L81	R:R:Y308	16.41	No	No	0	7	9
48	R:R:C83	R:R:F132	4.19	No	Yes	0	9	7
49	R:R:L84	R:R:S129	3	No	No	0	9	9
50	R:R:F132	R:R:L84	3.65	Yes	No	0	7	9
51	R:R:C87	R:R:V128	3.42	No	Yes	4	8	7
52	R:R:C87	R:R:F167	2.79	No	No	4	8	9
53	R:R:E88	R:R:Y91	12.35	Yes	Yes	1	9	7
54	R:R:D304	R:R:E88	10.39	No	Yes	0	9	9
55	R:R:E88	R:R:P305	4.72	Yes	No	1	9	9
56	R:R:F122	R:R:Y91	8.25	No	Yes	1	6	7
57	R:R:N125	R:R:Y91	15.12	No	Yes	1	9	7
58	R:R:I126	R:R:Y91	4.84	No	Yes	1	7	7
59	R:R:T298	R:R:Y91	4.99	No	Yes	0	7	7
60	R:R:G301	R:R:Y91	2.9	No	Yes	0	7	7
61	R:R:G93	R:R:T92	1.82	No	No	0	4	6
62	R:R:G93	R:R:P96	4.06	No	No	6	4	9
63	R:R:L97	R:R:Y101	5.86	No	No	0	6	5
64	R:R:W108	R:R:W98	10.31	Yes	No	2	9	6
65	R:R:T109	R:R:W98	4.85	No	No	2	4	6
66	R:R:L110	R:R:W98	2.28	No	No	2	6	6
67	R:R:N104	R:R:V99	2.96	Yes	No	0	4	7
68	R:R:I100	R:R:Y101	3.63	No	No	0	3	5
69	R:R:I102	R:R:W108	2.35	No	Yes	0	6	9
70	R:R:N104	R:R:R103	3.62	Yes	Yes	0	4	4
71	R:R:R103	R:R:V291	3.92	Yes	No	0	4	4
72	R:R:N104	R:R:W108	5.65	Yes	Yes	2	4	9
73	R:R:H106	R:R:W108	9.52	Yes	Yes	2	5	9
74	R:R:H106	R:R:L112	5.14	Yes	No	2	5	3
75	R:R:D188	R:R:H106	3.78	No	Yes	2	5	5
76	R:R:H106	R:R:M189	2.63	Yes	No	2	5	4
77	R:R:L112	R:R:W108	5.69	No	Yes	2	3	9
78	R:R:C115	R:R:W108	13.06	No	Yes	0	9	9
79	R:R:L110	R:R:T109	2.95	No	No	2	6	4
80	R:R:A114	R:R:L110	4.73	No	No	0	5	6
81	R:R:C186	R:R:L112	3.17	No	No	0	9	3
82	R:R:F178	R:R:K116	3.72	No	No	0	4	8
83	R:R:E181	R:R:K116	10.8	No	No	0	5	8
84	R:R:E184	R:R:K116	4.05	No	No	0	4	8
85	R:R:I121	R:R:V117	3.07	No	No	0	4	4
86	R:R:H174	R:R:Y120	6.53	Yes	No	0	6	5
87	R:R:F178	R:R:Y120	5.16	No	No	0	4	5
88	R:R:F122	R:R:F123	4.29	No	Yes	1	6	5
89	R:R:F122	R:R:I126	7.54	No	No	1	6	7
90	R:R:F123	R:R:H174	5.66	Yes	Yes	1	5	6
91	R:R:F123	R:R:Y200	2.06	Yes	Yes	1	5	5
92	R:R:F123	R:R:R203	8.55	Yes	Yes	1	5	5
93	R:R:C124	R:R:V128	1.71	No	Yes	0	5	7
94	R:R:C124	R:R:V170	1.71	No	Yes	0	5	7
95	R:R:I126	R:R:N125	2.83	No	No	1	7	9
96	R:R:V170	R:R:Y127	2.52	Yes	Yes	1	7	8
97	R:R:H174	R:R:Y127	2.18	Yes	Yes	1	6	8
98	R:R:R203	R:R:Y127	7.2	Yes	Yes	1	5	8
99	R:R:G207	R:R:Y127	4.35	No	Yes	0	6	8
100	R:R:F132	R:R:V128	7.87	Yes	Yes	4	7	7
101	R:R:F167	R:R:V128	10.49	No	Yes	4	9	7
102	R:R:I130	R:R:P211	3.39	No	Yes	0	7	9
103	R:R:F251	R:R:I130	3.77	Yes	No	0	9	7
104	R:R:I166	R:R:L131	4.28	No	No	0	6	5
105	R:R:F132	R:R:S163	2.64	Yes	No	0	7	6
106	R:R:F132	R:R:F167	2.14	Yes	No	4	7	9
107	R:R:F251	R:R:L133	4.87	Yes	No	0	9	8
108	R:R:C134	R:R:P211	3.77	No	Yes	0	7	9
109	R:R:C134	R:R:I214	3.27	No	No	0	7	6
110	R:R:I215	R:R:S137	4.64	No	No	0	8	9
111	R:R:S137	R:R:T218	6.4	No	Yes	0	9	6
112	R:R:D139	R:R:R140	3.57	No	No	0	8	9
113	R:R:F141	R:R:V145	10.49	Yes	No	0	8	7
114	R:R:F141	R:R:T218	6.49	Yes	Yes	0	8	6
115	R:R:F141	R:R:R221	4.28	Yes	Yes	0	8	4
116	R:R:F141	R:R:I222	3.77	Yes	No	0	8	8
117	R:R:S150	R:R:V142	3.23	No	No	0	6	5
118	R:R:R153	R:R:V142	3.92	No	No	0	4	5
119	R:R:A143	R:R:S150	1.71	No	No	0	8	6
120	R:R:V145	R:R:Y146	8.83	No	No	0	7	6
121	R:R:S225	R:R:V145	6.46	No	No	0	4	7
122	R:R:E149	R:R:Y146	3.37	No	No	0	4	6
123	R:R:R155	R:R:T158	6.47	No	No	0	6	2
124	R:R:I160	R:R:R157	3.76	No	No	0	3	4
125	R:R:I162	R:R:I166	2.94	No	No	0	4	6
126	R:R:G171	R:R:V170	1.84	No	Yes	0	3	7
127	R:R:H174	R:R:V170	2.77	Yes	Yes	1	6	7
128	R:R:H174	R:R:R203	10.16	Yes	Yes	1	6	5
129	R:R:T180	R:R:Y199	6.24	No	No	0	4	4
130	R:R:E181	R:R:K183	6.75	No	Yes	0	5	1
131	R:R:E181	R:R:M189	5.41	No	No	0	5	4
132	R:R:F187	R:R:K183	4.96	No	Yes	5	4	1
133	R:R:K183	R:R:M192	2.88	Yes	Yes	5	1	3
134	R:R:I196	R:R:K183	4.36	Yes	Yes	5	5	1
135	R:R:F187	R:R:T185	2.59	No	No	0	4	3
136	R:R:F187	R:R:M192	2.49	No	Yes	5	4	3
137	R:R:D188	R:R:Q191	7.83	No	No	2	5	4
138	R:R:L190	R:R:Y287	3.52	No	No	2	4	4
139	R:R:E283	R:R:Q191	7.65	No	No	0	3	4
140	R:R:I196	R:R:M192	2.92	Yes	Yes	5	5	3
141	R:R:S194	R:R:Y272	5.09	No	No	0	1	1
142	R:R:A197	R:R:F269	9.71	No	No	0	4	4
143	R:R:R203	R:R:Y200	3.09	Yes	Yes	1	5	5
144	R:R:F204	R:R:Y200	3.09	Yes	Yes	1	5	5
145	R:R:Y200	R:R:Y258	1.99	Yes	No	1	5	7
146	R:R:L262	R:R:Y200	11.72	Yes	Yes	1	6	5
147	R:R:K265	R:R:Y200	7.17	No	Yes	0	5	5
148	R:R:F204	R:R:Y201	11.35	Yes	Yes	1	5	4
149	R:R:T205	R:R:Y201	7.49	No	Yes	1	4	4
150	R:R:A266	R:R:Y201	5.34	No	Yes	1	5	4
151	R:R:F204	R:R:T205	11.67	Yes	No	1	5	4
152	R:R:F204	R:R:F208	13.93	Yes	No	1	5	8
153	R:R:F204	R:R:L262	3.65	Yes	Yes	1	5	6
154	R:R:A266	R:R:F204	5.55	No	Yes	1	5	5
155	R:R:G207	R:R:P211	2.03	No	Yes	0	6	9
156	R:R:F208	R:R:H259	14.71	No	No	0	8	8
157	R:R:F208	R:R:L262	6.09	No	Yes	1	8	6
158	R:R:I210	R:R:P211	3.39	No	Yes	0	5	9
159	R:R:I215	R:R:N219	2.83	No	Yes	8	8	9
160	R:R:I215	R:R:V248	3.07	No	No	8	8	6
161	R:R:F217	R:R:R221	9.62	No	Yes	0	4	4
162	R:R:N219	R:R:T218	2.92	Yes	Yes	0	9	6
163	R:R:A244	R:R:N219	3.13	No	Yes	0	6	9
164	R:R:N219	R:R:V248	2.96	Yes	No	8	9	6
165	R:R:H220	R:R:R221	11.28	No	Yes	0	4	4
166	R:R:R221	R:R:R224	5.33	Yes	No	0	4	4
167	R:R:F223	R:R:K241	14.89	No	No	0	4	5
168	R:R:I226	R:R:S229	3.1	No	No	0	8	5
169	R:R:I226	R:R:K237	4.36	No	No	0	8	6
170	R:R:I226	R:R:K241	2.91	No	No	0	8	5
171	R:R:K237	R:R:M230	5.76	No	No	0	6	3
172	R:R:L232	R:R:Q236	3.99	No	No	0	2	5
173	R:R:Q236	R:R:S233	4.33	No	No	0	5	3
174	R:R:A235	R:R:Q236	3.03	No	No	0	3	5
175	R:R:A238	R:R:H242	2.93	No	No	0	4	5
176	R:R:A311	R:R:V247	3.39	No	No	0	5	8
177	R:R:F251	R:R:F255	8.57	Yes	Yes	0	9	9
178	R:R:C254	R:R:F255	2.79	No	Yes	0	8	9
179	R:R:C254	R:R:N300	12.6	No	No	0	8	9
180	R:R:F255	R:R:H259	4.53	Yes	No	0	9	8
181	R:R:A256	R:R:P257	1.87	No	No	0	4	9
182	R:R:F293	R:R:P257	5.78	No	No	0	7	9
183	R:R:L262	R:R:Y258	18.76	Yes	No	1	6	7
184	R:R:E284	R:R:V261	4.28	No	No	0	4	5
185	R:R:F269	R:R:K265	7.44	No	No	0	4	5
186	R:R:A267	R:R:Y271	2.67	No	No	0	4	2
187	R:R:A268	R:R:D275	4.63	No	Yes	0	3	2
188	R:R:E283	R:R:F269	4.66	No	No	0	3	4
189	R:R:D275	R:R:Y271	2.3	Yes	No	3	2	2
190	R:R:R276	R:R:Y271	27.78	No	No	3	6	2
191	R:R:D275	R:R:R276	2.38	Yes	No	3	2	6
192	R:R:D275	R:R:N277	5.39	Yes	No	3	2	2
193	R:R:D275	R:R:L282	2.71	Yes	No	3	2	1
194	R:R:L282	R:R:N277	16.48	No	No	3	1	2
195	R:R:E283	R:R:M279	10.83	No	No	0	3	4
196	R:R:C280	R:R:R285	4.18	No	No	0	8	2
197	R:R:G281	R:R:R285	3	No	No	0	2	2
198	R:R:E284	R:R:S290	7.19	No	No	0	4	5
199	R:R:S290	R:R:Y287	6.36	No	No	0	5	4
200	R:R:S290	R:R:V291	3.23	No	No	0	5	4
201	R:R:L294	R:R:T298	2.95	No	No	0	6	7
202	R:R:C295	R:R:V299	1.71	No	No	0	5	5
203	R:R:D304	R:R:G301	3.35	No	No	0	9	7
204	R:R:A303	R:R:I306	4.87	No	No	0	6	5
205	R:R:T312	R:R:Y308	4.99	No	No	0	7	9
206	R:R:R316	R:R:V309	2.62	No	No	0	8	6
207	R:R:H314	R:R:L310	3.86	No	No	0	6	7
208	R:R:D313	R:R:T312	8.67	No	No	0	5	7
209	R:R:D313	R:R:R316	10.72	No	No	0	5	8
210	R:R:E318	R:R:R316	8.14	No	No	0	4	8
211	R:R:E318	R:R:R321	2.33	No	No	0	4	5
212	R:R:K324	R:R:S320	3.06	No	No	0	6	3
213	R:R:E328	R:R:G325	3.27	No	No	0	3	4
214	R:R:S330	R:R:W326	12.36	No	No	9	5	1
215	R:R:K332	R:R:W326	4.64	No	No	9	4	1
216	R:R:K327	R:R:T333	3	No	No	0	2	5
217	R:R:E328	R:R:W329	4.36	No	No	0	3	2
218	R:R:K332	R:R:S330	9.18	No	No	9	4	5
219	R:R:D343	R:R:T339	4.34	No	No	0	6	5
220	R:R:H340	R:R:T344	19.17	No	No	0	7	8
221	R:R:D343	R:R:R342	2.38	No	No	0	6	8
222	R:R:G56	R:R:N60	1.7	No	Yes	0	8	9
223	R:R:A78	R:R:V71	1.7	No	No	0	6	5
224	R:R:C115	R:R:T118	1.69	No	No	0	9	5
225	R:R:C138	R:R:I214	1.64	No	No	0	6	6
226	R:R:C254	R:R:I250	1.64	No	No	0	8	6
227	R:R:S225	R:R:S229	1.63	No	No	0	4	5
228	R:R:A59	R:R:I306	1.62	No	No	0	7	5
229	R:R:S243	R:R:V240	1.62	No	No	0	7	7
230	R:R:V71	R:R:V79	1.6	No	No	0	5	6
231	R:R:V247	R:R:V248	1.6	No	No	0	8	6
232	R:R:T92	R:R:V57	1.59	No	No	0	6	6
233	R:R:C165	R:R:L169	1.59	No	No	0	3	4
234	R:R:T333	R:R:V335	1.59	No	No	0	5	4
235	R:R:T336	R:R:V335	1.59	No	No	0	6	4
236	R:R:T339	R:R:V335	1.59	No	No	0	5	4
237	R:R:A64	R:R:L89	1.58	No	No	0	7	7
238	R:R:A256	R:R:L252	1.58	No	No	0	4	5
239	R:R:T118	R:R:T94	1.57	No	No	0	5	6
240	R:R:I160	R:R:S163	1.55	No	No	0	3	6
241	R:R:I43	R:R:V44	1.54	No	No	0	4	4
242	R:R:I43	R:R:V46	1.54	No	Yes	0	4	6
243	R:R:I43	R:R:V47	1.54	No	No	0	4	5
244	R:R:A143	R:R:D139	1.54	No	No	0	8	8
245	R:R:I196	R:R:V177	1.54	Yes	No	0	5	5
246	R:R:I210	R:R:V206	1.54	No	No	0	5	4
247	R:R:I245	R:R:V249	1.54	No	No	0	4	4
248	R:R:I162	R:R:T158	1.52	No	No	0	4	2
249	R:R:I196	R:R:T180	1.52	Yes	No	0	5	4
250	R:R:I214	R:R:T218	1.52	No	Yes	0	6	6
251	R:R:K239	R:R:V240	1.52	No	No	0	7	7
252	R:R:L338	R:R:S341	1.5	No	No	0	4	7
253	R:R:L55	R:R:V52	1.49	No	No	0	5	7
254	R:R:L68	R:R:V71	1.49	No	No	0	3	5
255	R:R:L260	R:R:V264	1.49	No	No	0	5	4
256	R:R:L282	R:R:V264	1.49	No	No	0	1	4
257	R:R:I168	R:R:I172	1.47	No	No	0	3	3
258	R:R:I250	R:R:I307	1.47	No	No	0	6	7
259	R:R:D139	R:R:V76	1.46	No	No	0	8	6
260	R:R:G198	R:R:Y201	1.45	No	Yes	0	3	4
261	R:R:I322	R:R:L62	1.43	No	No	0	4	5
262	R:R:I250	R:R:L310	1.43	No	No	0	6	7
263	R:R:Q179	R:R:T180	1.42	No	No	0	4	4
264	R:R:K237	R:R:L232	1.41	No	No	0	6	2
265	R:R:C135	R:R:F132	1.4	No	Yes	0	6	7
266	R:R:P176	R:R:Y175	1.39	No	No	0	8	4
267	R:R:D193	R:R:M192	1.39	No	Yes	0	1	3
268	R:R:L77	R:R:L81	1.38	No	No	0	7	7
269	R:R:L82	R:R:L86	1.38	No	No	0	5	5
270	R:R:L86	R:R:L89	1.38	No	No	0	5	7
271	R:R:L89	R:R:N60	1.37	No	Yes	0	7	9
272	R:R:D334	R:R:L338	1.36	No	No	0	5	4
273	R:R:F255	R:R:S297	1.32	Yes	No	0	9	8
274	R:R:H323	R:R:K324	1.31	No	No	0	3	6
275	R:R:F204	R:R:L263	1.22	Yes	No	0	5	5
276	R:R:F251	R:R:L212	1.22	Yes	No	0	9	5
277	R:R:I162	R:R:Y80	1.21	No	Yes	0	4	7
278	R:R:I121	R:R:Y120	1.21	No	No	0	4	5
279	R:R:Q105	R:R:R107	1.17	No	No	0	4	5
280	R:R:Q317	R:R:R321	1.17	No	No	0	4	5
281	R:R:L69	R:R:W65	1.14	No	No	0	4	3
282	R:R:R154	R:R:R156	1.07	No	No	0	7	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.6667	9	2	0
2	R:R:V46	2.61	4	0	6
3	R:R:Y49	8.175	4	0	8
4	R:R:N60	5.1975	4	1	9
5	R:R:Y80	4.5575	4	0	7
6	R:R:E88	10.48	4	1	9
7	R:R:Y91	8.075	6	1	7
8	R:R:R103	6.005	4	0	4
9	R:R:N104	3.965	4	2	4
10	R:R:H106	6.254	5	2	5
11	R:R:W108	8.08857	7	2	9
12	R:R:F123	5.14	4	1	5
13	R:R:Y127	4.0625	4	1	8
14	R:R:V128	5.8725	4	4	7
15	R:R:F132	3.64833	6	4	7
16	R:R:F141	6.2575	4	0	8
17	R:R:V170	2.21	4	1	7
18	R:R:H174	5.46	5	1	6
19	R:R:K183	4.7375	4	5	1
20	R:R:M192	2.42	4	5	3
21	R:R:I196	2.585	4	5	5
22	R:R:Y200	4.85333	6	1	5
23	R:R:Y201	6.4075	4	1	4
24	R:R:R203	7.25	4	1	5
25	R:R:F204	7.20857	7	1	5
26	R:R:P211	3.145	4	0	9
27	R:R:T218	4.3325	4	0	6
28	R:R:N219	2.96	4	8	9
29	R:R:R221	7.6275	4	0	4
30	R:R:F251	4.6075	4	0	9
31	R:R:F255	4.3025	4	0	9
32	R:R:L262	10.055	4	1	6
33	R:R:D275	3.482	5	3	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:N104	27.4371	3.63	Yes	Yes	2	0	4
2	R:R:N104	R:R:R103	33.4405	3.62	Yes	Yes	0	4	4
3	R:R:R103	R:R:V291	36.8078	3.92	Yes	No	0	4	4
4	R:R:L45	R:R:V291	41.9031	2.98	No	No	0	6	4
5	L:L:?1	R:R:Y287	20.4211	44.43	Yes	No	2	0	4
6	R:R:S290	R:R:Y287	18.5968	6.36	No	No	0	5	4
7	R:R:S290	R:R:V291	14.691	3.23	No	No	0	5	4
8	R:R:C295	R:R:L45	30.0088	3.17	No	No	0	5	6
9	R:R:N104	R:R:V99	27.2041	2.96	Yes	No	0	4	7
10	R:R:V46	R:R:V99	29.9767	3.21	Yes	No	0	6	7
11	R:R:R103	R:R:V46	17.5681	2.62	Yes	Yes	0	4	6
12	R:R:I100	R:R:V46	10.0538	3.07	No	Yes	0	3	6
13	R:R:V99	R:R:Y49	52.5356	2.52	No	Yes	0	7	8
14	R:R:P96	R:R:Y49	13.4935	18.08	No	Yes	0	9	8
15	R:R:T298	R:R:Y49	60.3793	6.24	No	Yes	0	7	8
16	R:R:C295	R:R:V299	18.0503	1.71	No	No	0	5	5
17	R:R:V299	R:R:V52	12.0469	4.81	No	No	0	5	7
18	R:R:T298	R:R:Y91	62.2921	4.99	No	Yes	0	7	7
19	R:R:E88	R:R:Y91	31.6001	12.35	Yes	Yes	1	9	7
20	R:R:E88	R:R:N60	22.816	14.46	Yes	Yes	1	9	9
21	R:R:G56	R:R:N60	11.6853	1.7	No	Yes	0	8	9
22	L:L:?1	R:R:M189	38.7366	6.23	Yes	No	2	0	4
23	R:R:E181	R:R:M189	49.9076	5.41	No	No	0	5	4
24	R:R:E181	R:R:K116	57.687	10.8	No	No	0	5	8
25	R:R:F178	R:R:K116	59.2622	3.72	No	No	0	4	8
26	R:R:F178	R:R:Y120	60.1543	5.16	No	No	0	4	5
27	R:R:H174	R:R:Y120	63.2886	6.53	Yes	No	0	6	5
28	R:R:H174	R:R:V170	73.254	2.77	Yes	Yes	1	6	7
29	R:R:C124	R:R:V170	100	1.71	No	Yes	0	5	7
30	R:R:C124	R:R:V128	98.4409	1.71	No	Yes	0	5	7
31	R:R:F132	R:R:V128	93.2894	7.87	Yes	Yes	4	7	7
32	R:R:C83	R:R:F132	67.8856	4.19	No	Yes	0	9	7
33	R:R:C83	R:R:V79	66.013	1.71	No	No	0	9	6
34	R:R:V71	R:R:V79	64.1244	1.6	No	No	0	5	6
35	R:R:A78	R:R:V71	56.4092	1.7	No	No	0	6	5
36	R:R:A78	R:R:N75	52.2623	3.13	No	No	7	6	7
37	R:R:L77	R:R:N75	50.4541	12.36	No	No	0	7	7
38	R:R:L77	R:R:L81	29.5588	1.38	No	No	0	7	7
39	R:R:L81	R:R:Y308	27.3809	16.41	No	No	0	7	9
40	R:R:T312	R:R:Y308	25.1869	4.99	No	No	0	7	9
41	R:R:D313	R:R:T312	22.9768	8.67	No	No	0	5	7
42	R:R:D313	R:R:R316	20.7506	10.72	No	No	0	5	8
43	R:R:E318	R:R:R316	16.2501	8.14	No	No	0	4	8
44	R:R:L77	R:R:R140	20.7506	7.29	No	No	0	7	9
45	R:R:D139	R:R:R140	18.5084	3.57	No	No	0	8	9
46	R:R:C135	R:R:F132	20.7506	1.4	No	Yes	0	6	7
47	R:R:C135	R:R:Y80	18.5084	6.72	No	Yes	0	6	7
48	R:R:F122	R:R:Y91	78.3653	8.25	No	Yes	1	6	7
49	L:L:?1	R:R:W108	15.2777	10.04	Yes	Yes	2	0	9
50	R:R:W108	R:R:W98	12.1434	10.31	Yes	No	2	9	6
51	L:L:?1	R:R:Q191	27.2844	5.87	Yes	No	2	0	4
52	R:R:E283	R:R:Q191	31.351	7.65	No	No	0	3	4
53	R:R:E283	R:R:F269	34.212	4.66	No	No	0	3	4
54	R:R:F269	R:R:K265	37.1213	7.44	No	No	0	4	5
55	R:R:K265	R:R:Y200	38.7286	7.17	No	Yes	0	5	5
56	R:R:F123	R:R:Y200	25.653	2.06	Yes	Yes	1	5	5
57	R:R:R203	R:R:Y200	37.941	3.09	Yes	Yes	1	5	5
58	R:R:H174	R:R:Y127	42.0317	2.18	Yes	Yes	1	6	8
59	R:R:R203	R:R:Y127	45.0293	7.2	Yes	Yes	1	5	8
60	R:R:G207	R:R:Y127	96.9702	4.35	No	Yes	0	6	8
61	R:R:G207	R:R:P211	94.961	2.03	No	Yes	0	6	9
62	R:R:I130	R:R:P211	14.7955	3.39	No	Yes	0	7	9
63	R:R:F204	R:R:Y200	31.15	3.09	Yes	Yes	1	5	5
64	R:R:F204	R:R:F208	16.009	13.93	Yes	No	1	5	8
65	R:R:F208	R:R:H259	27.2041	14.71	No	No	0	8	8
66	R:R:F255	R:R:H259	22.8402	4.53	Yes	No	0	9	8
67	R:R:F251	R:R:F255	12.5532	8.57	Yes	Yes	0	9	9
68	R:R:L262	R:R:Y200	17.9619	11.72	Yes	Yes	1	6	5
69	R:R:F208	R:R:L262	15.5589	6.09	No	Yes	1	8	6
70	R:R:I162	R:R:Y80	11.6853	1.21	No	Yes	0	4	7
71	R:R:C134	R:R:P211	81.2264	3.77	No	Yes	0	7	9
72	R:R:C134	R:R:I214	78.9681	3.27	No	No	0	7	6
73	R:R:I214	R:R:T218	74.339	1.52	No	Yes	0	6	6
74	R:R:N219	R:R:T218	16.4028	2.92	Yes	Yes	0	9	6
75	R:R:F141	R:R:T218	52.7124	6.49	Yes	Yes	0	8	6
76	R:R:F141	R:R:V145	37.5713	10.49	Yes	No	0	8	7
77	R:R:F141	R:R:R221	11.0504	4.28	Yes	Yes	0	8	4
78	R:R:S225	R:R:V145	29.7838	6.46	No	No	0	4	7
79	R:R:E181	R:R:K183	23.5393	6.75	No	Yes	0	5	1
80	R:R:I196	R:R:K183	11.8862	4.36	Yes	Yes	5	5	1
81	R:R:S225	R:R:S229	27.1558	1.63	No	No	0	4	5
82	R:R:I226	R:R:S229	24.5118	3.1	No	No	0	8	5
83	R:R:I226	R:R:K237	16.4832	4.36	No	No	0	8	6
84	R:R:K237	R:R:L232	11.0504	1.41	No	No	0	6	2
85	R:R:C254	R:R:F255	18.6048	2.79	No	Yes	0	8	9
86	R:R:C254	R:R:I250	12.4648	1.64	No	No	0	8	6
87	R:R:F123	R:R:H174	63.3449	5.66	Yes	Yes	1	5	6
88	R:R:F122	R:R:F123	82.3997	4.29	No	Yes	1	6	5
89	R:R:F123	R:R:R203	20.405	8.55	Yes	Yes	1	5	5
90	R:R:H106	R:R:M189	11.2995	2.63	Yes	No	2	5	4
91	R:R:H174	R:R:R203	13.5257	10.16	Yes	Yes	1	6	5
92	R:R:F251	R:R:I130	12.3363	3.77	Yes	No	0	9	7
93	R:R:V170	R:R:Y127	29.8079	2.52	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N104	3.63	2	Yes	Yes	0	4	0	1
L:L:?1	R:R:Q105	2.35	2	Yes	No	0	4	0	1
L:L:?1	R:R:H106	10.2	2	Yes	Yes	0	5	0	1
L:L:?1	R:R:W108	10.04	2	Yes	Yes	0	9	0	1
L:L:?1	R:R:D188	8.37	2	Yes	No	0	5	0	1
L:L:?1	R:R:M189	6.23	2	Yes	No	0	4	0	1
L:L:?1	R:R:L190	4.88	2	Yes	No	0	4	0	1
L:L:?1	R:R:Q191	5.87	2	Yes	No	0	4	0	1
L:L:?1	R:R:Y287	44.43	2	Yes	No	0	4	0	1
R:R:W108	R:R:W98	10.31	2	Yes	No	9	6	1	2
R:R:N104	R:R:V99	2.96	2	Yes	No	4	7	1	2
R:R:I102	R:R:W108	2.35	0	No	Yes	6	9	2	1
R:R:N104	R:R:R103	3.62	2	Yes	Yes	4	4	1	2
R:R:N104	R:R:W108	5.65	2	Yes	Yes	4	9	1	1
R:R:H106	R:R:W108	9.52	2	Yes	Yes	5	9	1	1
R:R:H106	R:R:L112	5.14	2	Yes	No	5	3	1	2
R:R:D188	R:R:H106	3.78	2	No	Yes	5	5	1	1
R:R:H106	R:R:M189	2.63	2	Yes	No	5	4	1	1
R:R:L112	R:R:W108	5.69	2	No	Yes	3	9	2	1
R:R:C115	R:R:W108	13.06	0	No	Yes	9	9	2	1
R:R:E181	R:R:M189	5.41	0	No	No	5	4	2	1
R:R:D188	R:R:Q191	7.83	2	No	No	5	4	1	1
R:R:L190	R:R:Y287	3.52	2	No	No	4	4	1	1
R:R:E283	R:R:Q191	7.65	0	No	No	3	4	2	1
R:R:S290	R:R:Y287	6.36	0	No	No	5	4	2	1
R:R:Q105	R:R:R107	1.17	0	No	No	4	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HVI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	1.71
Number of Linked Nodes	263
Number of Links	282
Number of Hubs	33
Number of Links mediated by Hubs	122
Number of Communities	9
Number of Nodes involved in Communities	58
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	36071
Length Of Smallest Path	3
Average Path Length	14.5847
Length of Longest Path	35
Minimum Path Strength	1.365
Average Path Strength	5.20318
Maximum Path Strength	27.315
Minimum Path Correlation	0.7
Average Path Correlation	0.964191
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	7.14286
Average % Of Corr. Nodes	64.1136
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7645
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• mitotic cell cycle process • cellular process • cell cycle phase transition • cell cycle • G1/S transition of mitotic cell cycle • cell cycle G1/S phase transition • mitotic cell cycle • mitotic cell cycle phase transition • cell cycle process • regulation of cell cycle phase transition • regulation of cellular process • G2/M transition of mitotic cell cycle • negative regulation of biological process • negative regulation of cell cycle • negative regulation of mitotic cell cycle • regulation of mitotic cell cycle • negative regulation of cellular process • negative regulation of cell cycle phase transition • regulation of cell cycle • cell cycle G2/M phase transition • regulation of biological process • negative regulation of mitotic cell cycle phase transition • regulation of G2/M transition of mitotic cell cycle • regulation of cell cycle process • biological regulation • regulation of cell cycle G2/M phase transition • negative regulation of cell cycle process • regulation of mitotic cell cycle phase transition • negative regulation of cell cycle G2/M phase transition • negative regulation of G2/M transition of mitotic cell cycle • electron transport chain • metabolic process • generation of precursor metabolites and energy • cell periphery • cellular anatomical structure • plasma membrane • membrane • periplasmic space • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • cellular response to stimulus • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • cellular component organization • cellular component organization or biogenesis • microtubule cytoskeleton organization involved in mitosis • spindle organization • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NFI
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NFI
Name	3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid
Synonyms
Identifier
Formula	C20 H17 N O5
Molecular Weight	351.353
SMILES
PubChem	168654812
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	0
Total Bonds	45
Total Aromatic Bonds	16


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9UNW8
Sequence	>8HVI_nogp_Chain_R E E S R I V L V V V Y S A V C T L G V P A N C L T A W L A L L Q V L Q G N V L A V Y L L C L A L C E L L Y T G T L P L W V I Y I R N Q H R W T L G L L A C K V T A Y I F F C N I Y V S I L F L C C I S C D R F V A V V Y A L E S R G R R R R R T A I L I S A C I F I L V G I V H Y P V F Q T E D K E T C F D M L Q M D S R I A G Y Y Y A R F T V G F A I P L S I I A F T N H R I F R S I K Q S M G L S A A Q K A K V K H S A I A V V V I F L V C F A P Y H L V L L V K A A A F S Y Y R G D R N A M C G L E E R L Y T A S V V F L C L S T V N G V A D P I I Y V L A T D H S R Q E V S R I H K G W K E W S M K T D V T R L T H S R D T E E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HVI	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-	Gi1/β1/γ2	3.04	2023-10-11	0.1038/s42255-023-00899-4
	8HVI (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NOX-6-7	-		3.04	2023-10-11	0.1038/s42255-023-00899-4
	8HQN	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-	Gi1/β1/γ2	3	2023-10-11	0.1038/s42255-023-00899-4
	8HQN (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	9-S-HODE	-		3	2023-10-11	0.1038/s42255-023-00899-4
	8HQM	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-	Gi1/β1/γ2	2.95	2023-10-11	0.1038/s42255-023-00899-4
	8HQM (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	NPGLY	-		2.95	2023-10-11	0.1038/s42255-023-00899-4
	8HQE	A	Orphan	Orphan	GPR132	Homo sapiens	-	-	Gi1/β1/γ2	2.97	2023-10-11	0.1038/s42255-023-00899-4
	8HQE (No Gprot)	A	Orphan	Orphan	GPR132	Homo sapiens	-	-		2.97	2023-10-11	0.1038/s42255-023-00899-4

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