psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L67	11.83	Yes	No	1	0	7
2	L:L:?1	R:R:S68	3.67	Yes	Yes	1	0	7
3	L:L:?1	R:R:V71	5.45	Yes	No	0	0	7
4	L:L:?1	R:R:M99	18.12	Yes	Yes	1	0	7
5	L:L:?1	R:R:G103	3.13	Yes	No	0	0	6
6	L:L:?1	R:R:S106	4.58	Yes	No	0	0	9
7	L:L:?1	R:R:W169	9.73	Yes	Yes	1	0	7
8	L:L:?1	R:R:F278	7.43	Yes	Yes	1	0	6
9	L:L:?1	R:R:R279	5.93	Yes	Yes	0	0	8
10	L:L:?1	R:R:Y281	12.16	Yes	Yes	1	0	7
11	L:L:?1	R:R:A282	10.58	Yes	No	0	0	7
12	L:L:?1	R:R:P285	12.03	Yes	No	0	0	9
13	R:R:Q162	R:R:R6	12.85	No	No	0	4	2
14	R:R:L8	R:R:Y10	5.86	No	No	0	2	2
15	R:R:G83	R:R:T9	3.64	No	No	0	2	7
16	R:R:R12	R:R:S14	3.95	No	No	0	2	3
17	R:R:S14	R:R:V15	3.23	No	No	0	3	2
18	R:R:V15	R:R:Y75	5.05	No	Yes	0	2	7
19	R:R:G16	R:R:P17	4.06	No	No	0	6	6
20	R:R:P17	R:R:Y75	5.56	No	Yes	0	6	7
21	R:R:R279	R:R:T19	9.06	Yes	No	0	8	4
22	R:R:S20	R:R:V71	4.85	No	No	0	7	7
23	R:R:F72	R:R:S20	5.28	Yes	No	0	6	7
24	R:R:F72	R:R:T21	6.49	Yes	No	0	6	5
25	R:R:M23	R:R:R279	6.2	No	Yes	0	7	8
26	R:R:F283	R:R:M23	13.68	No	No	0	5	7
27	R:R:F24	R:R:V28	7.87	Yes	No	0	6	7
28	R:R:F24	R:R:T64	3.89	Yes	No	1	6	7
29	R:R:F24	R:R:S68	10.57	Yes	Yes	1	6	7
30	R:R:F24	R:R:F72	10.72	Yes	Yes	1	6	6
31	R:R:A26	R:R:I286	3.25	No	No	0	5	8
32	R:R:G30	R:R:W290	5.63	No	No	0	9	7
33	R:R:D60	R:R:N31	6.73	Yes	Yes	0	9	9
34	R:R:L61	R:R:N31	8.24	No	Yes	0	7	9
35	R:R:N31	R:R:P289	4.89	Yes	No	0	9	9
36	R:R:A34	R:R:I293	4.87	No	Yes	0	9	8
37	R:R:A57	R:R:L35	3.15	No	No	0	8	7
38	R:R:I37	R:R:V299	13.83	No	No	0	8	7
39	R:R:L38	R:R:V53	4.47	Yes	Yes	3	7	8
40	R:R:I293	R:R:L38	4.28	Yes	Yes	3	8	7
41	R:R:A44	R:R:R41	4.15	No	No	0	5	7
42	R:R:P46	R:R:R45	4.32	No	No	0	7	6
43	R:R:A48	R:R:E116	4.53	No	No	0	7	9
44	R:R:F49	R:R:V53	3.93	No	Yes	0	8	8
45	R:R:A136	R:R:V51	3.39	No	No	0	6	6
46	R:R:L52	R:R:M113	5.65	No	Yes	0	7	9
47	R:R:A136	R:R:L52	3.15	No	No	0	6	7
48	R:R:M113	R:R:V53	3.04	Yes	Yes	0	9	8
49	R:R:I293	R:R:V53	3.07	Yes	Yes	3	8	8
50	R:R:G55	R:R:L140	3.42	No	No	0	7	7
51	R:R:D60	R:R:L56	6.79	Yes	Yes	0	9	9
52	R:R:I109	R:R:L56	7.14	No	Yes	0	7	9
53	R:R:L110	R:R:L56	4.15	No	Yes	0	8	9
54	R:R:L56	R:R:M113	5.65	Yes	Yes	0	9	9
55	R:R:I109	R:R:T59	4.56	No	No	0	7	9
56	R:R:T59	R:R:Y144	4.99	No	No	0	9	7
57	R:R:D60	R:R:S106	4.42	Yes	No	0	9	9
58	R:R:D60	R:R:P285	4.83	Yes	No	0	9	9
59	R:R:F102	R:R:G63	10.54	Yes	No	0	8	7
60	R:R:S68	R:R:T64	4.8	Yes	No	1	7	7
61	R:R:F102	R:R:F66	6.43	Yes	No	0	8	5
62	R:R:F95	R:R:L67	3.65	Yes	No	1	5	7
63	R:R:L67	R:R:M99	5.65	No	Yes	1	7	7
64	R:R:P69	R:R:S68	3.56	No	Yes	0	8	7
65	R:R:F72	R:R:S68	5.28	Yes	Yes	1	6	7
66	R:R:S168	R:R:Y75	11.45	No	Yes	0	8	7
67	R:R:L84	R:R:S79	7.51	No	No	0	5	3
68	R:R:Q163	R:R:S80	8.66	No	No	0	5	4
69	R:R:F95	R:R:L81	6.09	Yes	No	0	5	5
70	R:R:C170	R:R:L81	3.17	No	No	0	9	5
71	R:R:L82	R:R:P89	3.28	No	No	0	1	1
72	R:R:L82	R:R:Q163	10.65	No	No	0	1	5
73	R:R:A85	R:R:L91	4.73	No	No	0	5	4
74	R:R:G88	R:R:P89	4.06	No	No	0	4	1
75	R:R:C170	R:R:C92	5.46	No	No	0	9	9
76	R:R:D93	R:R:L155	4.07	No	No	4	3	4
77	R:R:D93	R:R:H161	7.56	No	Yes	4	3	6
78	R:R:F95	R:R:M99	3.73	Yes	Yes	1	5	7
79	R:R:A96	R:R:H161	8.78	No	Yes	0	7	6
80	R:R:C151	R:R:F97	4.19	No	No	0	7	6
81	R:R:F171	R:R:M99	4.98	Yes	Yes	1	7	7
82	R:R:C151	R:R:T100	5.07	No	No	0	7	6
83	R:R:F101	R:R:F102	6.43	No	Yes	0	7	8
84	R:R:C147	R:R:F101	4.19	No	No	0	7	7
85	R:R:L104	R:R:L108	6.92	Yes	Yes	1	6	5
86	R:R:C147	R:R:L104	9.52	No	Yes	0	7	6
87	R:R:F150	R:R:L104	3.65	Yes	Yes	1	6	6
88	R:R:L104	R:R:Y188	7.03	Yes	No	1	6	8
89	R:R:L104	R:R:L191	4.15	Yes	No	1	6	6
90	R:R:M107	R:R:V192	4.56	Yes	Yes	1	8	6
91	R:R:L195	R:R:M107	5.65	Yes	Yes	0	7	8
92	R:R:M107	R:R:V196	3.04	Yes	No	1	8	7
93	R:R:M107	R:R:Y281	4.79	Yes	Yes	1	8	7
94	R:R:I143	R:R:L108	5.71	No	Yes	0	7	5
95	R:R:L108	R:R:L195	4.15	Yes	Yes	0	5	7
96	R:R:D288	R:R:L110	8.14	No	No	0	9	8
97	R:R:F111	R:R:V115	6.55	Yes	No	0	6	6
98	R:R:F111	R:R:L195	6.09	Yes	Yes	0	6	7
99	R:R:A198	R:R:F111	4.16	No	Yes	0	5	6
100	R:R:F111	R:R:I199	3.77	Yes	Yes	0	6	8
101	R:R:F292	R:R:M113	7.46	No	Yes	0	9	9
102	R:R:A114	R:R:R117	4.15	No	No	0	9	9
103	R:R:A114	R:R:I199	4.87	No	Yes	0	9	8
104	R:R:A114	R:R:C202	3.61	No	No	0	9	7
105	R:R:E116	R:R:Y127	11.22	No	No	0	9	8
106	R:R:N203	R:R:R117	4.82	Yes	No	5	9	9
107	R:R:L241	R:R:R117	4.86	Yes	No	5	8	9
108	R:R:C118	R:R:C202	5.46	No	No	0	6	7
109	R:R:C118	R:R:S205	3.44	No	No	0	6	5
110	R:R:A120	R:R:Y127	6.67	No	No	0	8	8
111	R:R:L121	R:R:V206	4.47	No	No	0	8	9
112	R:R:H123	R:R:S122	9.76	No	No	0	5	7
113	R:R:S122	R:R:S205	3.26	No	No	0	7	5
114	R:R:S122	R:R:S209	3.26	No	No	0	7	6
115	R:R:L126	R:R:L130	4.15	No	No	0	4	4
116	R:R:D131	R:R:P133	3.22	No	Yes	0	5	4
117	R:R:D131	R:R:R134	5.96	No	No	0	5	5
118	R:R:G132	R:R:P133	4.06	No	Yes	0	6	4
119	R:R:P133	R:R:R137	4.32	Yes	No	0	4	4
120	R:R:L138	R:R:R134	3.64	No	No	0	4	5
121	R:R:F150	R:R:F184	8.57	Yes	No	0	6	6
122	R:R:F150	R:R:Y188	4.13	Yes	No	1	6	8
123	R:R:L153	R:R:P154	3.28	No	Yes	0	7	9
124	R:R:L153	R:R:L158	9.69	No	No	6	7	3
125	R:R:H161	R:R:P154	3.05	Yes	Yes	0	6	9
126	R:R:F184	R:R:P154	14.45	No	Yes	0	6	9
127	R:R:H161	R:R:L155	5.14	Yes	No	4	6	4
128	R:R:Q160	R:R:Q162	3.84	No	No	2	4	4
129	R:R:Q160	R:R:R173	11.68	No	No	2	4	5
130	R:R:Q160	R:R:W176	6.57	No	Yes	2	4	4
131	R:R:Q162	R:R:R173	11.68	No	No	2	4	5
132	R:R:C170	R:R:Q163	6.1	No	No	0	9	5
133	R:R:F171	R:R:Y164	4.13	Yes	No	1	7	7
134	R:R:M174	R:R:Y164	5.99	Yes	No	1	6	7
135	R:R:D274	R:R:Y164	4.6	Yes	No	1	7	7
136	R:R:P166	R:R:S168	3.56	No	No	0	7	8
137	R:R:P166	R:R:W169	12.16	No	Yes	0	7	7
138	R:R:F171	R:R:W169	11.02	Yes	Yes	1	7	7
139	R:R:L275	R:R:W169	5.69	No	Yes	0	6	7
140	R:R:F278	R:R:W169	17.04	Yes	Yes	1	6	7
141	R:R:F171	R:R:M174	6.22	Yes	Yes	1	7	6
142	R:R:F171	R:R:F278	20.36	Yes	Yes	1	7	6
143	R:R:F184	R:R:L172	6.09	No	No	0	6	5
144	R:R:L172	R:R:S185	6.01	No	No	0	5	6
145	R:R:R173	R:R:W176	37.99	No	Yes	2	5	4
146	R:R:C259	R:R:M174	4.86	No	Yes	0	6	6
147	R:R:M174	R:R:Q262	4.08	Yes	Yes	1	6	6
148	R:R:D274	R:R:M174	9.7	Yes	Yes	1	7	6
149	R:R:Q262	R:R:R175	8.18	Yes	No	0	6	3
150	R:R:P266	R:R:R175	5.76	No	No	0	3	3
151	R:R:G181	R:R:W176	11.26	No	Yes	0	6	4
152	R:R:A182	R:R:W176	5.19	No	Yes	0	2	4
153	R:R:P179	R:R:Q178	3.16	No	No	0	1	1
154	R:R:G180	R:R:Q178	3.29	No	No	0	1	1
155	R:R:A263	R:R:L186	4.73	No	No	0	5	4
156	R:R:V192	R:R:Y188	3.79	Yes	No	1	6	8
157	R:R:A189	R:R:C259	3.61	No	No	0	7	6
158	R:R:A189	R:R:F260	4.16	No	Yes	0	7	5
159	R:R:L191	R:R:L195	4.15	No	Yes	0	6	7
160	R:R:T256	R:R:V192	3.17	No	Yes	0	7	6
161	R:R:V192	R:R:Y281	3.79	Yes	Yes	1	6	7
162	R:R:F200	R:R:V196	7.87	No	No	1	5	7
163	R:R:M248	R:R:V196	4.56	No	No	1	8	7
164	R:R:I199	R:R:N203	4.25	Yes	Yes	0	8	9
165	R:R:I199	R:R:M248	10.2	Yes	No	0	8	8
166	R:R:F200	R:R:M248	3.73	No	No	1	5	8
167	R:R:A249	R:R:F200	4.16	No	No	0	6	5
168	R:R:L241	R:R:N203	12.36	Yes	Yes	5	8	9
169	R:R:N203	R:R:T245	7.31	Yes	No	0	9	8
170	R:R:L238	R:R:T207	5.9	No	Yes	0	7	7
171	R:R:L208	R:R:R212	13.36	No	No	0	2	4
172	R:R:E234	R:R:Y214	5.61	Yes	No	0	8	6
173	R:R:V235	R:R:Y214	3.79	No	No	0	4	6
174	R:R:E234	R:R:Q217	11.47	Yes	No	0	8	4
175	R:R:G222	R:R:Q221	4.93	No	No	0	4	5
176	R:R:H237	R:R:R296	3.39	No	No	0	8	8
177	R:R:L240	R:R:R296	6.07	No	No	0	8	8
178	R:R:L243	R:R:V291	7.45	No	Yes	0	5	8
179	R:R:M244	R:R:V291	4.56	No	Yes	0	8	8
180	R:R:F292	R:R:M244	11.2	No	No	0	9	8
181	R:R:L287	R:R:V247	4.47	No	No	0	7	7
182	R:R:A249	R:R:L253	3.15	No	No	0	6	6
183	R:R:C251	R:R:N284	4.72	No	Yes	0	8	9
184	R:R:S252	R:R:Y281	5.09	No	Yes	0	8	7
185	R:R:N284	R:R:S252	4.47	Yes	No	0	9	8
186	R:R:C259	R:R:L255	3.17	No	No	0	6	6
187	R:R:F278	R:R:L255	6.09	Yes	No	0	6	6
188	R:R:L255	R:R:Y281	10.55	No	Yes	0	6	7
189	R:R:F260	R:R:T256	3.89	Yes	No	0	5	7
190	R:R:R258	R:R:T261	6.47	Yes	No	0	5	4
191	R:R:Q262	R:R:R258	9.35	Yes	Yes	1	6	5
192	R:R:D274	R:R:R258	10.72	Yes	Yes	1	7	5
193	R:R:D274	R:R:Q262	9.14	Yes	Yes	1	7	6
194	R:R:E271	R:R:S269	11.5	No	No	0	3	1
195	R:R:E271	R:R:G273	6.55	No	No	0	3	2
196	R:R:G273	R:R:M272	5.24	No	No	0	2	1
197	R:R:L275	R:R:R279	4.86	No	Yes	0	6	8
198	R:R:F280	R:R:L276	7.31	No	No	0	6	3
199	R:R:N284	R:R:P285	8.15	Yes	No	0	9	9
200	R:R:D288	R:R:N284	12.12	No	Yes	0	9	9
201	R:R:D288	R:R:F292	3.58	No	No	0	9	9
202	R:R:L294	R:R:W290	5.69	No	No	0	7	7
203	R:R:F295	R:R:W290	9.02	No	No	0	5	7
204	R:R:F295	R:R:V291	3.93	No	Yes	0	5	8
205	R:R:L303	R:R:W306	3.42	Yes	No	0	4	4
206	R:R:C311	R:R:L312	3.17	No	No	0	1	4
207	R:R:F260	R:R:G190	3.01	Yes	No	0	5	4
208	R:R:L119	R:R:V115	2.98	No	No	0	4	6
209	R:R:L210	R:R:V206	2.98	No	No	0	8	9
210	R:R:L241	R:R:V206	2.98	Yes	No	0	8	9
211	R:R:L240	R:R:V291	2.98	No	Yes	0	8	8
212	R:R:L243	R:R:V247	2.98	No	No	0	5	7
213	R:R:L38	R:R:T54	2.95	Yes	No	0	7	6
214	R:R:L241	R:R:T207	2.95	Yes	Yes	0	8	7
215	R:R:I293	R:R:I37	2.94	Yes	No	0	8	8
216	R:R:I286	R:R:M23	2.92	No	No	0	8	7
217	R:R:F280	R:R:P254	2.89	No	No	0	6	9
218	R:R:I109	R:R:L140	2.85	No	No	0	7	7
219	R:R:C165	R:R:R12	2.79	No	No	0	2	2
220	R:R:A50	R:R:R41	2.77	No	No	0	7	7
221	R:R:A70	R:R:F95	2.77	No	Yes	0	5	5
222	R:R:A98	R:R:F102	2.77	No	Yes	0	5	8
223	R:R:A193	R:R:F260	2.77	No	Yes	0	5	5
224	R:R:A277	R:R:R258	2.77	No	Yes	0	7	5
225	R:R:E116	R:R:L52	2.65	No	No	0	9	7
226	R:R:F66	R:R:S65	2.64	No	No	0	5	5
227	R:R:R137	R:R:V51	2.62	No	No	0	4	6
228	R:R:F97	R:R:V148	2.62	No	No	0	6	4
229	R:R:F101	R:R:V148	2.62	No	No	0	7	4
230	R:R:F280	R:R:V250	2.62	No	No	0	6	5
231	R:R:V11	R:R:Y75	2.52	No	Yes	0	3	7
232	R:R:F102	R:R:L62	2.44	Yes	No	0	8	5
233	R:R:F146	R:R:L104	2.44	No	Yes	1	4	6
234	R:R:F146	R:R:L108	2.44	No	Yes	1	4	5
235	R:R:F146	R:R:L191	2.44	No	No	1	4	6
236	R:R:F260	R:R:L186	2.44	Yes	No	0	5	4
237	R:R:L38	R:R:R41	2.43	Yes	No	0	7	7
238	R:R:L303	R:R:R302	2.43	Yes	No	0	4	6
239	R:R:K218	R:R:Y214	2.39	No	No	0	2	6
240	R:R:L310	R:R:W306	2.28	No	No	0	4	4
241	R:R:G83	R:R:G87	2.11	No	No	0	2	3
242	R:R:G87	R:R:G88	2.11	No	No	0	3	4
243	R:R:G180	R:R:G181	2.11	No	No	0	1	6
244	R:R:G159	R:R:P154	2.03	No	Yes	0	8	9
245	R:R:G167	R:R:P166	2.03	No	No	0	4	7
246	R:R:A26	R:R:G27	1.95	No	No	0	5	8
247	R:R:P133	R:R:P46	1.95	Yes	No	0	4	7
248	R:R:A58	R:R:G55	1.95	No	No	0	5	7
249	R:R:A277	R:R:P254	1.87	No	No	0	7	9
250	R:R:A265	R:R:P266	1.87	No	No	0	3	3
251	R:R:G83	R:R:S79	1.86	No	No	0	2	3
252	R:R:G13	R:R:V11	1.84	No	No	0	2	3
253	R:R:G30	R:R:V29	1.84	No	No	0	9	4
254	R:R:G204	R:R:T207	1.82	No	Yes	0	4	7
255	R:R:A105	R:R:C147	1.81	No	No	0	6	7
256	R:R:A182	R:R:A263	1.79	No	No	0	2	5
257	R:R:C5	R:R:S270	1.72	No	No	0	9	4
258	R:R:A50	R:R:S47	1.71	No	No	0	7	7
259	R:R:A74	R:R:S168	1.71	No	No	0	6	8
260	R:R:G157	R:R:L158	1.71	No	No	0	6	3
261	R:R:G313	R:R:L312	1.71	No	No	0	1	4
262	R:R:C211	R:R:T207	1.69	No	Yes	0	5	7
263	R:R:D274	R:R:G273	1.68	Yes	No	0	7	2
264	R:R:L140	R:R:P141	1.64	No	No	0	7	2
265	R:R:A112	R:R:I143	1.62	No	No	0	7	7
266	R:R:C308	R:R:K304	1.62	No	No	0	3	3
267	R:R:V25	R:R:V29	1.6	No	No	0	5	4
268	R:R:V246	R:R:V250	1.6	No	No	0	5	5
269	R:R:C5	R:R:L8	1.59	No	No	0	9	2
270	R:R:C308	R:R:L312	1.59	No	No	0	3	4
271	R:R:C309	R:R:L310	1.59	No	No	0	8	4
272	R:R:A57	R:R:N31	1.56	No	Yes	0	8	9
273	R:R:I239	R:R:V235	1.54	No	No	0	6	4
274	R:R:H123	R:R:P124	1.53	No	No	0	5	8
275	R:R:I257	R:R:T256	1.52	No	No	0	6	7
276	R:R:I257	R:R:T261	1.52	No	No	0	6	4
277	R:R:L84	R:R:V73	1.49	No	No	0	5	5
278	R:R:L149	R:R:V148	1.49	No	No	0	3	4
279	R:R:N78	R:R:V11	1.48	No	No	0	4	3
280	R:R:D267	R:R:S269	1.47	No	No	0	1	1
281	R:R:P43	R:R:R42	1.44	No	No	0	4	6
282	R:R:I37	R:R:L303	1.43	No	Yes	0	8	4
283	R:R:L210	R:R:M213	1.41	No	No	0	8	7
284	R:R:C5	R:R:R12	1.39	No	No	0	9	2
285	R:R:A187	R:R:F150	1.39	No	Yes	0	4	6
286	R:R:C211	R:R:R215	1.39	No	No	0	5	5
287	R:R:L294	R:R:L33	1.38	No	No	0	7	4
288	R:R:L303	R:R:L33	1.38	Yes	No	0	4	4
289	R:R:L119	R:R:L130	1.38	No	No	0	4	4
290	R:R:L153	R:R:L156	1.38	No	No	6	7	3
291	R:R:L156	R:R:L158	1.38	No	No	6	3	3
292	R:R:E234	R:R:L210	1.33	Yes	No	0	8	8
293	R:R:D233	R:R:D236	1.33	No	No	0	6	8
294	R:R:R77	R:R:S79	1.32	No	No	0	4	3
295	R:R:D236	R:R:E232	1.3	No	No	0	8	6
296	R:R:E232	R:R:E234	1.27	No	Yes	0	6	8
297	R:R:H220	R:R:Q216	1.24	No	No	0	4	4
298	R:R:K218	R:R:R219	1.24	No	No	0	2	2
299	R:R:F300	R:R:K297	1.24	No	No	0	7	6
300	R:R:V307	R:R:W306	1.23	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.72	12	1	0
2	R:R:F24	8.2625	4	1	6
3	R:R:N31	5.355	4	0	9
4	R:R:L38	3.5325	4	3	7
5	R:R:V53	3.6275	4	3	8
6	R:R:L56	5.9325	4	0	9
7	R:R:D60	5.6925	4	0	9
8	R:R:S68	5.576	5	1	7
9	R:R:F72	6.9425	4	1	6
10	R:R:Y75	6.145	4	0	7
11	R:R:F95	4.06	4	1	5
12	R:R:M99	8.12	4	1	7
13	R:R:F102	5.722	5	0	8
14	R:R:L104	5.61833	6	1	6
15	R:R:M107	4.51	4	1	8
16	R:R:L108	4.805	4	1	5
17	R:R:F111	5.1425	4	0	6
18	R:R:M113	5.45	4	0	9
19	R:R:P133	3.3875	4	0	4
20	R:R:F150	4.435	4	1	6
21	R:R:P154	5.7025	4	0	9
22	R:R:H161	6.1325	4	4	6
23	R:R:W169	11.128	5	1	7
24	R:R:F171	9.342	5	1	7
25	R:R:M174	6.17	5	1	6
26	R:R:W176	15.2525	4	2	4
27	R:R:V192	3.8275	4	1	6
28	R:R:L195	5.01	4	0	7
29	R:R:I199	5.7725	4	0	8
30	R:R:N203	7.185	4	5	9
31	R:R:T207	3.09	4	0	7
32	R:R:E234	4.92	4	0	8
33	R:R:L241	5.7875	4	5	8
34	R:R:R258	7.3275	4	1	5
35	R:R:F260	3.254	5	0	5
36	R:R:Q262	7.6875	4	1	6
37	R:R:D274	7.168	5	1	7
38	R:R:F278	12.73	4	1	6
39	R:R:R279	6.5125	4	0	8
40	R:R:Y281	7.276	5	1	7
41	R:R:N284	7.365	4	0	9
42	R:R:V291	4.73	4	0	8
43	R:R:I293	3.79	4	3	8
44	R:R:L303	2.165	4	0	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y281	84.9232	12.16	Yes	Yes	1	0	7
2	R:R:V192	R:R:Y281	43.7964	3.79	Yes	Yes	1	6	7
3	R:R:T256	R:R:V192	27.9909	3.17	No	Yes	0	7	6
4	R:R:F260	R:R:T256	20.8598	3.89	Yes	No	0	5	7
5	R:R:F260	R:R:L186	20.4458	2.44	Yes	No	0	5	4
6	R:R:A263	R:R:L186	19.0282	4.73	No	No	0	5	4
7	R:R:A182	R:R:A263	17.604	1.79	No	No	0	2	5
8	R:R:A182	R:R:W176	16.1732	5.19	No	Yes	0	2	4
9	L:L:?1	R:R:W169	39.9974	9.73	Yes	Yes	1	0	7
10	R:R:P166	R:R:W169	25.3345	12.16	No	Yes	0	7	7
11	R:R:P166	R:R:S168	22.6252	3.56	No	No	0	7	8
12	R:R:S168	R:R:Y75	19.8894	11.45	No	Yes	0	8	7
13	R:R:V15	R:R:Y75	11.5229	5.05	No	Yes	0	2	7
14	R:R:S14	R:R:V15	10.1053	3.23	No	No	0	3	2
15	L:L:?1	R:R:L67	18.0313	11.83	Yes	No	1	0	7
16	R:R:F95	R:R:L67	17.0674	3.65	Yes	No	1	5	7
17	R:R:F95	R:R:L81	34.476	6.09	Yes	No	0	5	5
18	R:R:C170	R:R:L81	32.2238	3.17	No	No	0	9	5
19	R:R:C170	R:R:Q163	27.6994	6.1	No	No	0	9	5
20	R:R:L82	R:R:Q163	23.1485	10.65	No	No	0	1	5
21	R:R:L82	R:R:P89	20.8631	3.28	No	No	0	1	1
22	R:R:G88	R:R:P89	18.5711	4.06	No	No	0	4	1
23	R:R:G87	R:R:G88	16.2725	2.11	No	No	0	3	4
24	R:R:G83	R:R:G87	13.9673	2.11	No	No	0	2	3
25	L:L:?1	R:R:M99	37.2682	18.12	Yes	Yes	1	0	7
26	R:R:F95	R:R:M99	21.774	3.73	Yes	Yes	1	5	7
27	L:L:?1	R:R:R279	11.566	5.93	Yes	Yes	0	0	8
28	L:L:?1	R:R:S68	10.5624	3.67	Yes	Yes	1	0	7
29	L:L:?1	R:R:P285	69.5184	12.03	Yes	No	0	0	9
30	R:R:N284	R:R:P285	12.6391	8.15	Yes	No	0	9	9
31	R:R:D288	R:R:N284	38.4473	12.12	No	Yes	0	9	9
32	R:R:D288	R:R:F292	36.0758	3.58	No	No	0	9	9
33	R:R:F292	R:R:M244	19.8463	11.2	No	No	0	9	8
34	R:R:M244	R:R:V291	18.4983	4.56	No	Yes	0	8	8
35	L:L:?1	R:R:S106	57.1244	4.58	Yes	No	0	0	9
36	R:R:D60	R:R:S106	56.2103	4.42	Yes	No	0	9	9
37	R:R:D60	R:R:P285	56.3129	4.83	Yes	No	0	9	9
38	R:R:D60	R:R:N31	12.4503	6.73	Yes	Yes	0	9	9
39	R:R:D60	R:R:L56	100	6.79	Yes	Yes	0	9	9
40	R:R:L56	R:R:M113	81.6971	5.65	Yes	Yes	0	9	9
41	R:R:M113	R:R:V53	54.4515	3.04	Yes	Yes	0	9	8
42	R:R:I293	R:R:V53	31.5382	3.07	Yes	Yes	3	8	8
43	R:R:I293	R:R:I37	26.1129	2.94	Yes	No	0	8	8
44	R:R:L38	R:R:V53	17.243	4.47	Yes	Yes	3	7	8
45	R:R:L38	R:R:R41	11.8177	2.43	Yes	No	0	7	7
46	R:R:L52	R:R:M113	43.8659	5.65	No	Yes	0	7	9
47	R:R:A136	R:R:L52	29.4085	3.15	No	No	0	6	7
48	R:R:A136	R:R:V51	26.4971	3.39	No	No	0	6	6
49	R:R:R137	R:R:V51	23.5791	2.62	No	No	0	4	6
50	R:R:P133	R:R:R137	20.6545	4.32	Yes	No	0	4	4
51	R:R:E116	R:R:L52	11.8376	2.65	No	No	0	9	7
52	R:R:I109	R:R:L56	17.4318	7.14	No	Yes	0	7	9
53	R:R:V192	R:R:Y188	32.5484	3.79	Yes	No	1	6	8
54	R:R:L104	R:R:Y188	16.6899	7.03	Yes	No	1	6	8
55	R:R:C147	R:R:L104	19.3793	9.52	No	Yes	0	7	6
56	R:R:C147	R:R:F101	16.6899	4.19	No	No	0	7	7
57	R:R:F150	R:R:Y188	14.9874	4.13	Yes	No	1	6	8
58	R:R:F150	R:R:F184	17.3556	8.57	Yes	No	0	6	6
59	R:R:F184	R:R:P154	13.4307	14.45	No	Yes	0	6	9
60	R:R:F171	R:R:M99	24.374	4.98	Yes	Yes	1	7	7
61	L:L:?1	R:R:F278	21.5951	7.43	Yes	Yes	1	0	6
62	R:R:F171	R:R:F278	20.3332	20.36	Yes	Yes	1	7	6
63	R:R:M107	R:R:Y281	72.3105	4.79	Yes	Yes	1	8	7
64	R:R:L195	R:R:M107	44.3528	5.65	Yes	Yes	0	7	8
65	R:R:M107	R:R:V196	37.3741	3.04	Yes	No	1	8	7
66	R:R:F111	R:R:L195	46.2175	6.09	Yes	Yes	0	6	7
67	R:R:F111	R:R:I199	39.8384	3.77	Yes	Yes	0	6	8
68	R:R:M248	R:R:V196	32.7703	4.56	No	No	1	8	7
69	R:R:I199	R:R:M248	32.2271	10.2	Yes	No	0	8	8
70	R:R:A114	R:R:I199	19.694	4.87	No	Yes	0	9	8
71	R:R:I199	R:R:N203	49.9603	4.25	Yes	Yes	0	8	9
72	R:R:A114	R:R:C202	15.8784	3.61	No	No	0	9	7
73	R:R:L241	R:R:N203	43.4917	12.36	Yes	Yes	5	8	9
74	R:R:C118	R:R:C202	13.6294	5.46	No	No	0	6	7
75	R:R:C118	R:R:S205	11.3739	3.44	No	No	0	6	5
76	R:R:L241	R:R:V206	31.0513	2.98	Yes	No	0	8	9
77	R:R:F171	R:R:Y164	23.3671	4.13	Yes	No	1	7	7
78	R:R:F171	R:R:W169	25.4505	11.02	Yes	Yes	1	7	7
79	R:R:F171	R:R:M174	41.4282	6.22	Yes	Yes	1	7	6
80	R:R:D274	R:R:Y164	20.2901	4.6	Yes	No	1	7	7
81	R:R:D274	R:R:M174	23.9964	9.7	Yes	Yes	1	7	6
82	R:R:C259	R:R:L255	10.5227	3.17	No	No	0	6	6
83	R:R:L255	R:R:Y281	10.5359	10.55	No	Yes	0	6	7
84	R:R:M174	R:R:Q262	19.9126	4.08	Yes	Yes	1	6	6
85	R:R:L241	R:R:T207	11.3408	2.95	Yes	Yes	0	8	7
86	R:R:L210	R:R:V206	26.6528	2.98	No	No	0	8	9
87	R:R:E234	R:R:L210	22.2277	1.33	Yes	No	0	8	8
88	R:R:E234	R:R:Y214	11.1884	5.61	Yes	No	0	8	6
89	R:R:S252	R:R:Y281	28.6864	5.09	No	Yes	0	8	7
90	R:R:D274	R:R:R258	23.4565	10.72	Yes	Yes	1	7	5
91	R:R:Q262	R:R:R258	12.1489	9.35	Yes	Yes	1	6	5
92	R:R:D274	R:R:G273	18.9587	1.68	Yes	No	0	7	2
93	R:R:E271	R:R:G273	11.3937	6.55	No	No	0	3	2
94	R:R:A277	R:R:R258	32.3298	2.77	No	Yes	0	7	5
95	R:R:A277	R:R:P254	26.9575	1.87	No	No	0	7	9
96	R:R:F280	R:R:P254	21.5786	2.89	No	No	0	6	9
97	R:R:I37	R:R:L303	20.5386	1.43	No	Yes	0	8	4
98	R:R:L303	R:R:W306	11.8409	3.42	Yes	No	0	4	4
99	R:R:F280	R:R:V250	10.8009	2.62	No	No	0	6	5
100	R:R:F292	R:R:M113	18.8626	7.46	No	Yes	0	9	9
101	R:R:N284	R:R:S252	28.077	4.47	Yes	No	0	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L67	11.83	1	Yes	No	0	7	0	1
L:L:?1	R:R:S68	3.67	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V71	5.45	1	Yes	No	0	7	0	1
L:L:?1	R:R:M99	18.12	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:G103	3.13	1	Yes	No	0	6	0	1
L:L:?1	R:R:S106	4.58	1	Yes	No	0	9	0	1
L:L:?1	R:R:W169	9.73	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F278	7.43	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R279	5.93	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y281	12.16	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:A282	10.58	1	Yes	No	0	7	0	1
L:L:?1	R:R:P285	12.03	1	Yes	No	0	9	0	1
R:R:R279	R:R:T19	9.06	0	Yes	No	8	4	1	2
R:R:S20	R:R:V71	4.85	0	No	No	7	7	2	1
R:R:F72	R:R:S20	5.28	1	Yes	No	6	7	2	2
R:R:M23	R:R:R279	6.2	0	No	Yes	7	8	2	1
R:R:F24	R:R:T64	3.89	1	Yes	No	6	7	2	2
R:R:F24	R:R:S68	10.57	1	Yes	Yes	6	7	2	1
R:R:F24	R:R:F72	10.72	1	Yes	Yes	6	6	2	2
R:R:D60	R:R:S106	4.42	0	Yes	No	9	9	2	1
R:R:D60	R:R:P285	4.83	0	Yes	No	9	9	2	1
R:R:S68	R:R:T64	4.8	1	Yes	No	7	7	1	2
R:R:F95	R:R:L67	3.65	1	Yes	No	5	7	2	1
R:R:L67	R:R:M99	5.65	1	No	Yes	7	7	1	1
R:R:P69	R:R:S68	3.56	0	No	Yes	8	7	2	1
R:R:F72	R:R:S68	5.28	1	Yes	Yes	6	7	2	1
R:R:F95	R:R:M99	3.73	1	Yes	Yes	5	7	2	1
R:R:F171	R:R:M99	4.98	1	Yes	Yes	7	7	2	1
R:R:M107	R:R:V192	4.56	1	Yes	Yes	8	6	2	2
R:R:M107	R:R:Y281	4.79	1	Yes	Yes	8	7	2	1
R:R:P166	R:R:W169	12.16	0	No	Yes	7	7	2	1
R:R:F171	R:R:W169	11.02	1	Yes	Yes	7	7	2	1
R:R:L275	R:R:W169	5.69	0	No	Yes	6	7	2	1
R:R:F278	R:R:W169	17.04	1	Yes	Yes	6	7	1	1
R:R:F171	R:R:F278	20.36	1	Yes	Yes	7	6	2	1
R:R:V192	R:R:Y281	3.79	1	Yes	Yes	6	7	2	1
R:R:S252	R:R:Y281	5.09	0	No	Yes	8	7	2	1
R:R:N284	R:R:S252	4.47	0	Yes	No	9	8	2	2
R:R:F278	R:R:L255	6.09	1	Yes	No	6	6	1	2
R:R:L255	R:R:Y281	10.55	0	No	Yes	6	7	2	1
R:R:L275	R:R:R279	4.86	0	No	Yes	6	8	2	1
R:R:N284	R:R:P285	8.15	0	Yes	No	9	9	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X79_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	271
Number of Links	300
Number of Hubs	44
Number of Links mediated by Hubs	154
Number of Communities	6
Number of Nodes involved in Communities	44
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	80971
Length Of Smallest Path	3
Average Path Length	13.5524
Length of Longest Path	27
Minimum Path Strength	1.285
Average Path Strength	5.92279
Maximum Path Strength	24.835
Minimum Path Correlation	0.7
Average Path Correlation	0.936791
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	55.3686
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2661
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of cell communication • cell surface receptor protein tyrosine kinase signaling pathway • negative regulation of cellular process • enzyme-linked receptor protein signaling pathway • regulation of signaling • cell surface receptor signaling pathway • negative regulation of response to stimulus • negative regulation of platelet-derived growth factor receptor signaling pathway • platelet-derived growth factor receptor signaling pathway • negative regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • defense response • response to stress • inflammatory response • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • cell-cell signaling • biological process involved in interspecies interaction between organisms • response to lipid • response to other organism • response to oxygen-containing compound • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to chemical • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • immune response • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Y9Q
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	Y9Q
Name	2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid
Synonyms
Identifier
Formula	C25 H29 N3 O3
Molecular Weight	419.516
SMILES
PubChem	9931891
Formal Charge	0
Total Atoms	60
Total Chiral Atoms	0
Total Bonds	62
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43119
Sequence	>8X79_nogp_Chain_R S C R N L T Y V R G S V G P A T S T L M F V A G V V G N G L A L G I L S A R R P A R P S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N S S L L G L A R G G P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H P Y L Y A Q L D G P R C A R L A L P A I Y A F C V L F C A L P L L G L G Q H Q Q Y C P G S W C F L R M R W A Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q G E D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A P D S S S E M G D L L A F R F Y A F N P I L D P W V F I L F R K A V F Q R L K L W V C C L C L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8I2G	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340	Gs/β1/γ2	2.8	2023-03-29	doi.org/10.1038/s41467-023-36170-3
	8I2G (No Gprot)	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340		2.8	2023-03-29	doi.org/10.1038/s41467-023-36170-3
	8I2H	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	-	-	-	6	2023-03-22	doi.org/10.1038/s41467-023-36170-3
	9II2	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	Glutamate	-	Arrestin2	3.7	2025-03-05	doi.org/10.1038/s41589-025-01858-8
	6LI2	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	8X79	A	Lipid	Prostanoid	I2	Homo sapiens	MRE-269	-	Gs/β1/γ2	2.41	2024-03-06	doi.org/10.1126/sciadv.adk5184
	8X79 (No Gprot)	A	Lipid	Prostanoid	I2	Homo sapiens	MRE-269	-		2.41	2024-03-06	doi.org/10.1126/sciadv.adk5184
	8X7A	A	Lipid	Prostanoid	I2	Homo sapiens	Treprostinil	-	Gs/β1/γ2	2.56	2024-03-06	doi.org/10.1126/sciadv.adk5184
	8X7A (No Gprot)	A	Lipid	Prostanoid	I2	Homo sapiens	Treprostinil	-		2.56	2024-03-06	doi.org/10.1126/sciadv.adk5184

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