psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:S20	12.44	Yes	No	0	0	7
2	L:L:?1	R:R:T64	5.63	Yes	No	0	0	7
3	L:L:?1	R:R:L67	9.7	Yes	No	1	0	7
4	L:L:?1	R:R:V71	7.59	Yes	No	1	0	7
5	L:L:?1	R:R:F95	5.43	Yes	Yes	1	0	5
6	L:L:?1	R:R:S168	8.61	Yes	No	1	0	8
7	L:L:?1	R:R:W169	5.8	Yes	Yes	1	0	7
8	L:L:?1	R:R:F278	10.09	Yes	Yes	1	0	6
9	L:L:?1	R:R:R279	10.06	Yes	Yes	1	0	8
10	L:L:?1	R:R:Y281	2.99	Yes	Yes	1	0	7
11	L:L:?1	R:R:A282	9.03	Yes	No	0	0	7
12	L:L:?1	R:R:P285	7.32	Yes	No	0	0	9
13	R:R:M23	R:R:T19	3.01	Yes	No	1	7	4
14	R:R:R279	R:R:T19	7.76	Yes	No	1	8	4
15	R:R:L22	R:R:T21	4.42	No	No	0	5	5
16	R:R:M23	R:R:R279	6.2	Yes	Yes	1	7	8
17	R:R:F283	R:R:M23	16.17	No	Yes	1	5	7
18	R:R:I286	R:R:M23	4.37	No	Yes	1	8	7
19	R:R:F24	R:R:V28	5.24	No	No	0	6	7
20	R:R:F24	R:R:S68	15.85	No	No	1	6	7
21	R:R:F24	R:R:F72	4.29	No	No	1	6	6
22	R:R:G27	R:R:I286	5.29	No	No	0	8	8
23	R:R:T64	R:R:V28	3.17	No	No	0	7	7
24	R:R:S65	R:R:V28	3.23	No	No	0	5	7
25	R:R:L33	R:R:V29	2.98	No	No	0	4	4
26	R:R:G30	R:R:P289	4.06	No	No	0	9	9
27	R:R:G30	R:R:W290	5.63	No	No	0	9	7
28	R:R:D60	R:R:N31	6.73	No	No	0	9	9
29	R:R:L61	R:R:N31	6.87	No	No	0	7	9
30	R:R:N31	R:R:P289	6.52	No	No	0	9	9
31	R:R:A57	R:R:L35	3.15	No	No	0	8	7
32	R:R:I37	R:R:V299	3.07	No	Yes	0	8	7
33	R:R:L38	R:R:V53	7.45	No	No	0	7	8
34	R:R:L38	R:R:T54	4.42	No	No	0	7	6
35	R:R:R41	R:R:V299	3.92	No	Yes	0	7	7
36	R:R:R302	R:R:R41	4.26	No	No	0	6	7
37	R:R:A50	R:R:R42	5.53	No	No	0	7	6
38	R:R:P46	R:R:R45	11.53	No	No	0	7	6
39	R:R:P133	R:R:P46	3.9	Yes	No	0	4	7
40	R:R:A50	R:R:S47	3.42	No	No	0	7	7
41	R:R:A48	R:R:E116	4.53	No	No	0	7	9
42	R:R:F49	R:R:M113	4.98	No	Yes	0	8	9
43	R:R:E116	R:R:F49	4.66	No	No	0	9	8
44	R:R:A136	R:R:V51	3.39	No	No	0	6	6
45	R:R:R137	R:R:V51	3.92	No	No	0	4	6
46	R:R:L52	R:R:M113	5.65	No	Yes	0	7	9
47	R:R:A136	R:R:L52	3.15	No	No	0	6	7
48	R:R:M113	R:R:V53	3.04	Yes	No	0	9	8
49	R:R:G55	R:R:L140	3.42	No	No	0	7	7
50	R:R:D60	R:R:L56	9.5	No	No	0	9	9
51	R:R:I109	R:R:L56	5.71	No	No	0	7	9
52	R:R:L110	R:R:L56	5.54	No	No	0	8	9
53	R:R:I109	R:R:T59	4.56	No	No	0	7	9
54	R:R:T59	R:R:Y144	3.75	No	No	0	9	7
55	R:R:D60	R:R:P285	6.44	No	No	0	9	9
56	R:R:L61	R:R:S65	4.5	No	No	0	7	5
57	R:R:F102	R:R:L62	6.09	Yes	No	0	8	5
58	R:R:F102	R:R:G63	9.03	Yes	No	0	8	7
59	R:R:F95	R:R:L67	8.53	Yes	No	1	5	7
60	R:R:P69	R:R:S68	5.34	No	No	0	8	7
61	R:R:F72	R:R:S68	9.25	No	No	1	6	7
62	R:R:F72	R:R:V71	3.93	No	No	1	6	7
63	R:R:S168	R:R:V71	4.85	No	No	1	8	7
64	R:R:L84	R:R:V73	2.98	No	No	0	5	5
65	R:R:L84	R:R:R77	4.86	No	No	0	5	4
66	R:R:Q163	R:R:S80	4.33	No	No	0	5	4
67	R:R:L81	R:R:L91	5.54	No	No	0	5	4
68	R:R:C92	R:R:L81	4.76	Yes	No	0	9	5
69	R:R:F95	R:R:L81	4.87	Yes	No	0	5	5
70	R:R:L82	R:R:Q163	5.32	No	No	0	1	5
71	R:R:L84	R:R:L91	4.15	No	No	0	5	4
72	R:R:A85	R:R:L91	3.15	No	No	0	5	4
73	R:R:G88	R:R:P89	4.06	No	No	0	4	1
74	R:R:D93	R:R:P89	6.44	No	No	0	3	1
75	R:R:C92	R:R:D93	3.11	Yes	No	0	9	3
76	R:R:C170	R:R:C92	3.64	No	Yes	0	9	9
77	R:R:D93	R:R:H161	6.3	No	No	0	3	6
78	R:R:F95	R:R:M99	4.98	Yes	Yes	1	5	7
79	R:R:A96	R:R:H161	8.78	No	No	0	7	6
80	R:R:A96	R:R:C170	3.61	No	No	0	7	9
81	R:R:C151	R:R:F97	4.19	No	No	0	7	6
82	R:R:M99	R:R:W169	4.65	Yes	Yes	1	7	7
83	R:R:F171	R:R:M99	3.73	Yes	Yes	1	7	7
84	R:R:F278	R:R:M99	6.22	Yes	Yes	1	6	7
85	R:R:C151	R:R:T100	5.07	No	No	0	7	6
86	R:R:F101	R:R:F102	7.5	No	Yes	0	7	8
87	R:R:C147	R:R:F101	5.59	No	No	0	7	7
88	R:R:G103	R:R:Y281	4.35	No	Yes	0	6	7
89	R:R:L104	R:R:L108	4.15	Yes	Yes	0	6	5
90	R:R:C147	R:R:L104	6.35	No	Yes	0	7	6
91	R:R:F150	R:R:L104	3.65	No	Yes	0	6	6
92	R:R:C151	R:R:L104	3.17	No	Yes	0	7	6
93	R:R:L104	R:R:Y188	7.03	Yes	No	0	6	8
94	R:R:L104	R:R:L191	4.15	Yes	No	0	6	6
95	R:R:M107	R:R:V192	4.56	No	Yes	1	8	6
96	R:R:M107	R:R:S252	6.13	No	Yes	1	8	8
97	R:R:M107	R:R:Y281	5.99	No	Yes	1	8	7
98	R:R:I143	R:R:L108	7.14	No	Yes	0	7	5
99	R:R:L108	R:R:L195	5.54	Yes	No	0	5	7
100	R:R:D288	R:R:L110	4.07	No	No	0	9	8
101	R:R:F111	R:R:V115	7.87	No	No	0	6	6
102	R:R:F111	R:R:L195	4.87	No	No	0	6	7
103	R:R:A114	R:R:I199	4.87	No	No	0	9	8
104	R:R:A114	R:R:C202	3.61	No	No	0	9	7
105	R:R:L119	R:R:V115	2.98	No	No	0	4	6
106	R:R:E116	R:R:Y127	7.86	No	No	0	9	8
107	R:R:N203	R:R:R117	7.23	Yes	No	3	9	9
108	R:R:R117	R:R:V206	5.23	No	Yes	3	9	9
109	R:R:L241	R:R:R117	7.29	No	No	3	8	9
110	R:R:C118	R:R:S122	3.44	No	Yes	4	6	7
111	R:R:C118	R:R:C202	3.64	No	No	0	6	7
112	R:R:C118	R:R:S205	3.44	No	No	4	6	5
113	R:R:A120	R:R:Y127	9.34	No	No	0	8	8
114	R:R:L121	R:R:V206	4.47	No	Yes	0	8	9
115	R:R:H123	R:R:S122	4.18	No	Yes	0	5	7
116	R:R:S122	R:R:S205	4.89	Yes	No	4	7	5
117	R:R:S122	R:R:S209	4.89	Yes	No	0	7	6
118	R:R:H123	R:R:L126	5.14	No	No	0	5	4
119	R:R:D131	R:R:P133	6.44	No	Yes	0	5	4
120	R:R:D131	R:R:R134	5.96	No	No	0	5	5
121	R:R:G132	R:R:P133	4.06	No	Yes	0	6	4
122	R:R:P133	R:R:R137	4.32	Yes	No	0	4	4
123	R:R:L138	R:R:R134	8.5	No	No	0	4	5
124	R:R:L140	R:R:Y144	3.52	No	No	0	7	7
125	R:R:F150	R:R:F184	13.93	No	Yes	0	6	6
126	R:R:L153	R:R:L158	9.69	No	No	0	7	3
127	R:R:F184	R:R:L153	7.31	Yes	No	0	6	7
128	R:R:L172	R:R:P154	3.28	Yes	No	1	5	9
129	R:R:F184	R:R:P154	18.78	Yes	No	1	6	9
130	R:R:Q160	R:R:R173	3.5	No	No	0	4	5
131	R:R:H161	R:R:L172	3.86	No	Yes	0	6	5
132	R:R:G167	R:R:Q163	4.93	No	No	0	4	5
133	R:R:W169	R:R:Y164	19.29	Yes	Yes	1	7	7
134	R:R:F171	R:R:Y164	4.13	Yes	Yes	1	7	7
135	R:R:M174	R:R:Y164	7.18	Yes	Yes	1	6	7
136	R:R:E271	R:R:Y164	17.96	Yes	Yes	1	3	7
137	R:R:D274	R:R:Y164	4.6	Yes	Yes	1	7	7
138	R:R:C165	R:R:E271	6.08	No	Yes	0	2	3
139	R:R:P166	R:R:W169	5.4	No	Yes	1	7	7
140	R:R:E271	R:R:P166	11	Yes	No	1	3	7
141	R:R:L275	R:R:P166	13.14	Yes	No	1	6	7
142	R:R:F171	R:R:W169	8.02	Yes	Yes	1	7	7
143	R:R:E271	R:R:W169	7.63	Yes	Yes	1	3	7
144	R:R:L275	R:R:W169	6.83	Yes	Yes	1	6	7
145	R:R:F278	R:R:W169	29.06	Yes	Yes	1	6	7
146	R:R:F171	R:R:L172	4.87	Yes	Yes	1	7	5
147	R:R:F171	R:R:M174	4.98	Yes	Yes	1	7	6
148	R:R:F171	R:R:F278	3.22	Yes	Yes	1	7	6
149	R:R:F184	R:R:L172	7.31	Yes	Yes	1	6	5
150	R:R:L172	R:R:S185	3	Yes	No	0	5	6
151	R:R:R173	R:R:W176	32.99	No	No	0	5	4
152	R:R:M174	R:R:S185	3.07	Yes	No	0	6	6
153	R:R:C259	R:R:M174	6.48	No	Yes	0	6	6
154	R:R:M174	R:R:Q262	4.08	Yes	Yes	1	6	6
155	R:R:D274	R:R:M174	8.32	Yes	Yes	1	7	6
156	R:R:Q262	R:R:R175	7.01	Yes	Yes	1	6	3
157	R:R:D267	R:R:R175	23.82	No	Yes	1	1	3
158	R:R:E271	R:R:R175	3.49	Yes	Yes	1	3	3
159	R:R:D274	R:R:R175	3.57	Yes	Yes	1	7	3
160	R:R:A177	R:R:Q178	4.55	No	No	0	1	1
161	R:R:P179	R:R:V264	8.84	No	No	0	1	3
162	R:R:V192	R:R:Y188	3.79	Yes	No	1	6	8
163	R:R:Y188	R:R:Y281	4.96	No	Yes	1	8	7
164	R:R:A189	R:R:C259	3.61	No	No	0	7	6
165	R:R:A189	R:R:F260	4.16	No	Yes	0	7	5
166	R:R:F260	R:R:G190	3.01	Yes	No	0	5	4
167	R:R:S252	R:R:V192	4.85	Yes	Yes	1	8	6
168	R:R:T256	R:R:V192	3.17	No	Yes	0	7	6
169	R:R:V192	R:R:Y281	3.79	Yes	Yes	1	6	7
170	R:R:F200	R:R:V196	6.55	No	Yes	1	5	7
171	R:R:M248	R:R:V196	6.09	No	Yes	1	8	7
172	R:R:S252	R:R:V196	3.23	Yes	Yes	1	8	7
173	R:R:L253	R:R:V196	4.47	No	Yes	0	6	7
174	R:R:I199	R:R:N203	4.25	No	Yes	0	8	9
175	R:R:I199	R:R:M248	7.29	No	No	0	8	8
176	R:R:F200	R:R:M248	3.73	No	No	1	5	8
177	R:R:L241	R:R:N203	10.98	No	Yes	3	8	9
178	R:R:N203	R:R:T245	7.31	Yes	No	0	9	8
179	R:R:L210	R:R:V206	2.98	Yes	Yes	0	8	9
180	R:R:L241	R:R:V206	2.98	No	Yes	3	8	9
181	R:R:L238	R:R:T207	7.37	No	No	0	7	7
182	R:R:L208	R:R:R212	4.86	No	No	0	2	4
183	R:R:K218	R:R:Y214	4.78	No	No	0	2	6
184	R:R:E234	R:R:Y214	11.22	No	No	0	8	6
185	R:R:V235	R:R:Y214	3.79	No	No	0	4	6
186	R:R:R215	R:R:R219	6.4	No	No	0	5	2
187	R:R:Q217	R:R:Q221	3.84	No	No	0	4	5
188	R:R:H220	R:R:R219	5.64	No	No	0	4	2
189	R:R:G222	R:R:Q221	6.58	No	No	0	4	5
190	R:R:D236	R:R:E232	3.9	No	No	0	8	6
191	R:R:D236	R:R:K297	6.91	No	No	0	8	6
192	R:R:L240	R:R:R296	3.64	No	No	0	8	8
193	R:R:L243	R:R:V247	2.98	No	No	2	5	7
194	R:R:L243	R:R:V291	2.98	No	Yes	2	5	8
195	R:R:F295	R:R:L243	8.53	No	No	0	5	5
196	R:R:M244	R:R:V291	3.04	No	Yes	2	8	8
197	R:R:F292	R:R:M244	18.66	No	No	2	9	8
198	R:R:L287	R:R:V247	2.98	No	No	0	7	7
199	R:R:V247	R:R:V291	4.81	No	Yes	2	7	8
200	R:R:A249	R:R:L253	3.15	No	No	0	6	6
201	R:R:C251	R:R:N284	7.87	No	No	0	8	9
202	R:R:S252	R:R:Y281	5.09	Yes	Yes	1	8	7
203	R:R:F280	R:R:P254	8.67	No	No	0	6	9
204	R:R:C259	R:R:L255	3.17	No	No	0	6	6
205	R:R:F278	R:R:L255	3.65	Yes	No	0	6	6
206	R:R:L255	R:R:Y281	15.24	No	Yes	0	6	7
207	R:R:F260	R:R:T256	3.89	Yes	No	0	5	7
208	R:R:G273	R:R:R258	4.5	No	Yes	0	2	5
209	R:R:A277	R:R:R258	5.53	No	Yes	0	7	5
210	R:R:A265	R:R:T261	3.36	No	No	0	3	4
211	R:R:D267	R:R:Q262	7.83	No	Yes	1	1	6
212	R:R:D274	R:R:Q262	11.75	Yes	Yes	1	7	6
213	R:R:A265	R:R:P266	3.74	No	No	0	3	3
214	R:R:M272	R:R:S270	4.6	No	No	0	1	4
215	R:R:D274	R:R:E271	9.09	Yes	Yes	1	7	3
216	R:R:E271	R:R:L275	6.63	Yes	Yes	1	3	6
217	R:R:L275	R:R:R279	8.5	Yes	Yes	1	6	8
218	R:R:F280	R:R:L276	9.74	No	No	0	6	3
219	R:R:F283	R:R:I286	3.77	No	No	1	5	8
220	R:R:F283	R:R:L287	8.53	No	No	0	5	7
221	R:R:D288	R:R:N284	8.08	No	No	0	9	9
222	R:R:L294	R:R:W290	10.25	No	No	0	7	7
223	R:R:F292	R:R:V291	5.24	No	Yes	2	9	8
224	R:R:I293	R:R:V299	4.61	No	Yes	0	8	7
225	R:R:F300	R:R:L294	3.65	No	No	0	7	7
226	R:R:R296	R:R:V299	5.23	No	Yes	0	8	7
227	R:R:R302	R:R:W306	5	No	No	0	6	4
228	R:R:L303	R:R:V307	2.98	No	No	0	4	4
229	R:R:C308	R:R:K304	6.47	No	No	0	3	3
230	R:R:L305	R:R:W306	4.56	No	No	0	4	4
231	R:R:G313	R:R:L312	3.42	No	No	0	1	4
232	R:R:I37	R:R:L303	2.85	No	No	0	8	4
233	R:R:L210	R:R:M213	2.83	Yes	No	0	8	7
234	R:R:L240	R:R:M244	2.83	No	No	0	8	8
235	R:R:L303	R:R:L33	2.77	No	No	0	4	4
236	R:R:A70	R:R:F95	2.77	No	Yes	0	5	5
237	R:R:A98	R:R:F102	2.77	No	Yes	0	5	8
238	R:R:A198	R:R:F111	2.77	No	No	0	5	6
239	R:R:L126	R:R:L130	2.77	No	No	0	4	4
240	R:R:A193	R:R:F260	2.77	No	Yes	0	5	5
241	R:R:L210	R:R:L238	2.77	Yes	No	0	8	7
242	R:R:F66	R:R:S65	2.64	No	No	0	5	5
243	R:R:F97	R:R:V148	2.62	No	No	0	6	4
244	R:R:F101	R:R:V148	2.62	No	No	0	7	4
245	R:R:A40	R:R:W306	2.59	No	No	0	5	4
246	R:R:R258	R:R:T261	2.59	Yes	No	0	5	4
247	R:R:S168	R:R:Y75	2.54	No	No	0	8	7
248	R:R:D233	R:R:H237	2.52	No	No	0	6	8
249	R:R:F292	R:R:M113	2.49	No	Yes	0	9	9
250	R:R:H220	R:R:Q216	2.47	No	No	0	4	4
251	R:R:F146	R:R:L108	2.44	No	Yes	0	4	5
252	R:R:F260	R:R:L186	2.44	Yes	No	0	5	4
253	R:R:L38	R:R:R42	2.43	No	No	0	7	6
254	R:R:D274	R:R:R258	2.38	Yes	Yes	0	7	5
255	R:R:Q162	R:R:R173	2.34	No	No	0	4	5
256	R:R:Q216	R:R:R212	2.34	No	No	0	4	4
257	R:R:H237	R:R:R296	2.26	No	No	0	8	8
258	R:R:G83	R:R:G87	2.11	No	No	0	2	3
259	R:R:G87	R:R:G88	2.11	No	No	0	3	4
260	R:R:G180	R:R:G181	2.11	No	No	0	1	6
261	R:R:G159	R:R:P154	2.03	No	No	0	8	9
262	R:R:C135	R:R:G132	1.96	No	No	0	5	6
263	R:R:A26	R:R:G27	1.95	No	No	0	5	8
264	R:R:A58	R:R:G55	1.95	No	No	0	5	7
265	R:R:A277	R:R:P254	1.87	No	No	0	7	9
266	R:R:G103	R:R:S106	1.86	No	No	0	6	9
267	R:R:G204	R:R:T207	1.82	No	No	0	4	7
268	R:R:A105	R:R:C147	1.81	No	No	0	6	7
269	R:R:A34	R:R:A57	1.79	No	No	0	9	8
270	R:R:G273	R:R:M272	1.75	No	No	0	2	1
271	R:R:G36	R:R:L35	1.71	No	No	0	3	7
272	R:R:G157	R:R:L158	1.71	No	No	0	6	3
273	R:R:C311	R:R:V307	1.71	No	No	0	1	4
274	R:R:C211	R:R:T207	1.69	No	No	0	5	7
275	R:R:A18	R:R:T19	1.68	No	No	0	4	4
276	R:R:L140	R:R:P141	1.64	No	No	0	7	2
277	R:R:G159	R:R:Q160	1.64	No	No	0	8	4
278	R:R:L186	R:R:P179	1.64	No	No	0	4	1
279	R:R:S268	R:R:S270	1.63	No	No	0	1	4
280	R:R:A34	R:R:I293	1.62	No	No	0	9	8
281	R:R:A112	R:R:I143	1.62	No	No	0	7	7
282	R:R:V25	R:R:V29	1.6	No	No	0	5	4
283	R:R:V246	R:R:V250	1.6	No	No	0	5	5
284	R:R:T21	R:R:V25	1.59	No	No	0	5	5
285	R:R:C92	R:R:L82	1.59	Yes	No	0	9	1
286	R:R:C309	R:R:L305	1.59	No	No	0	8	4
287	R:R:P179	R:R:Q178	1.58	No	No	0	1	1
288	R:R:A183	R:R:L186	1.58	No	No	0	4	4
289	R:R:I239	R:R:V235	1.54	No	No	0	6	4
290	R:R:H123	R:R:P124	1.53	No	No	0	5	8
291	R:R:I257	R:R:T256	1.52	No	No	0	6	7
292	R:R:I257	R:R:T261	1.52	No	No	0	6	4
293	R:R:D267	R:R:S269	1.47	No	No	0	1	1
294	R:R:P43	R:R:R42	1.44	No	No	0	4	6
295	R:R:A152	R:R:F97	1.39	No	No	0	5	6
296	R:R:P124	R:R:Y125	1.39	No	No	0	8	7
297	R:R:A187	R:R:F150	1.39	No	No	0	4	6
298	R:R:L156	R:R:L158	1.38	No	No	0	3	3
299	R:R:K297	R:R:Q301	1.36	No	No	0	6	5
300	R:R:E234	R:R:L210	1.33	No	Yes	0	8	8
301	R:R:D233	R:R:D236	1.33	No	No	0	6	8
302	R:R:R77	R:R:S79	1.32	No	No	0	4	3
303	R:R:A263	R:R:W176	1.3	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.89083	12	1	0
2	R:R:M23	7.4375	4	1	7
3	R:R:C92	3.275	4	0	9
4	R:R:F95	5.316	5	1	5
5	R:R:M99	4.895	4	1	7
6	R:R:F102	6.3475	4	0	8
7	R:R:L104	4.75	6	0	6
8	R:R:L108	4.8175	4	0	5
9	R:R:M113	4.04	4	0	9
10	R:R:S122	4.35	4	4	7
11	R:R:P133	4.68	4	0	4
12	R:R:Y164	10.632	5	1	7
13	R:R:W169	10.835	8	1	7
14	R:R:F171	4.825	6	1	7
15	R:R:L172	4.464	5	1	5
16	R:R:M174	5.685	6	1	6
17	R:R:R175	9.4725	4	1	3
18	R:R:F184	11.8325	4	1	6
19	R:R:V192	4.032	5	1	6
20	R:R:V196	5.085	4	1	7
21	R:R:N203	7.4425	4	3	9
22	R:R:V206	3.915	4	3	9
23	R:R:L210	2.4775	4	0	8
24	R:R:S252	4.825	4	1	8
25	R:R:R258	3.75	4	0	5
26	R:R:F260	3.254	5	0	5
27	R:R:Q262	7.6675	4	1	6
28	R:R:E271	8.84	7	1	3
29	R:R:D274	6.61833	6	1	7
30	R:R:L275	8.775	4	1	6
31	R:R:F278	10.448	5	1	6
32	R:R:R279	8.13	4	1	8
33	R:R:Y281	6.05857	7	1	7
34	R:R:V291	4.0175	4	2	8
35	R:R:V299	4.2075	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:R279	84.1488	10.06	Yes	Yes	1	0	8
2	R:R:M23	R:R:R279	100	6.2	Yes	Yes	1	7	8
3	R:R:F283	R:R:M23	94.9803	16.17	No	Yes	1	5	7
4	R:R:F283	R:R:L287	94.9017	8.53	No	No	0	5	7
5	R:R:L287	R:R:V247	93.6861	2.98	No	No	0	7	7
6	R:R:V247	R:R:V291	89.4527	4.81	No	Yes	2	7	8
7	R:R:M244	R:R:V291	47.3783	3.04	No	Yes	2	8	8
8	R:R:L240	R:R:M244	50.4868	2.83	No	No	0	8	8
9	R:R:L240	R:R:R296	48.8539	3.64	No	No	0	8	8
10	R:R:R296	R:R:V299	37.4599	5.23	No	Yes	0	8	7
11	R:R:I37	R:R:V299	16.6374	3.07	No	Yes	0	8	7
12	R:R:I37	R:R:L303	14.9864	2.85	No	No	0	8	4
13	L:L:?1	R:R:T64	10.5534	5.63	Yes	No	0	0	7
14	L:L:?1	R:R:P285	36.6132	7.32	Yes	No	0	0	9
15	R:R:D60	R:R:P285	34.9803	6.44	No	No	0	9	9
16	R:R:D60	R:R:N31	12.9664	6.73	No	No	0	9	9
17	R:R:F292	R:R:V291	41.4938	5.24	No	Yes	2	9	8
18	R:R:F292	R:R:M113	44.5479	2.49	No	Yes	0	9	9
19	R:R:M113	R:R:V53	13.1297	3.04	Yes	No	0	9	8
20	R:R:L38	R:R:V53	11.2489	7.45	No	No	0	7	8
21	R:R:R41	R:R:V299	11.0674	3.92	No	Yes	0	7	7
22	R:R:L52	R:R:M113	22.4917	5.65	No	Yes	0	7	9
23	R:R:A136	R:R:L52	20.6834	3.15	No	No	0	6	7
24	R:R:A136	R:R:V51	18.863	3.39	No	No	0	6	6
25	R:R:R137	R:R:V51	17.0305	3.92	No	No	0	4	6
26	R:R:P133	R:R:R137	15.186	4.32	Yes	No	0	4	4
27	R:R:D60	R:R:L56	21.9837	9.5	No	No	0	9	9
28	R:R:I109	R:R:L56	13.033	5.71	No	No	0	7	9
29	R:R:I109	R:R:T59	11.2065	4.56	No	No	0	7	9
30	L:L:?1	R:R:Y281	86.5195	2.99	Yes	Yes	1	0	7
31	R:R:Y188	R:R:Y281	35.6033	4.96	No	Yes	1	8	7
32	R:R:L104	R:R:Y188	50.2873	7.03	Yes	No	0	6	8
33	R:R:C147	R:R:L104	15.9722	6.35	No	Yes	0	7	6
34	R:R:C147	R:R:F101	12.0532	5.59	No	No	0	7	7
35	L:L:?1	R:R:F95	28.4608	5.43	Yes	Yes	1	0	5
36	R:R:F95	R:R:L81	31.0674	4.87	Yes	No	0	5	5
37	R:R:L81	R:R:L91	13.3112	5.54	No	No	0	5	4
38	R:R:C92	R:R:L81	18.0284	4.76	Yes	No	0	9	5
39	R:R:C92	R:R:L82	10.3236	1.59	Yes	No	0	9	1
40	L:L:?1	R:R:W169	36.4318	5.8	Yes	Yes	1	0	7
41	R:R:F171	R:R:W169	24.56	8.02	Yes	Yes	1	7	7
42	R:R:F171	R:R:L172	47.7956	4.87	Yes	Yes	1	7	5
43	R:R:H161	R:R:L172	14.932	3.86	No	Yes	0	6	5
44	L:L:?1	R:R:F278	20.254	10.09	Yes	Yes	1	0	6
45	R:R:F171	R:R:F278	19.6008	3.22	Yes	Yes	1	7	6
46	R:R:L104	R:R:L108	18.0647	4.15	Yes	Yes	0	6	5
47	R:R:F150	R:R:L104	16.8854	3.65	No	Yes	0	6	6
48	R:R:V192	R:R:Y281	11.0009	3.79	Yes	Yes	1	6	7
49	R:R:S252	R:R:Y281	65.9631	5.09	Yes	Yes	1	8	7
50	R:R:L108	R:R:L195	10.1542	5.54	Yes	No	0	5	7
51	R:R:S252	R:R:V196	83.2598	3.23	Yes	Yes	1	8	7
52	R:R:M248	R:R:V196	76.8793	6.09	No	Yes	1	8	7
53	R:R:I199	R:R:M248	75.5791	7.29	No	No	0	8	8
54	R:R:A114	R:R:I199	21.9292	4.87	No	No	0	9	8
55	R:R:A114	R:R:C202	19.9819	3.61	No	No	0	9	7
56	R:R:I199	R:R:N203	56.0629	4.25	No	Yes	0	8	9
57	R:R:N203	R:R:R117	26.2474	7.23	Yes	No	3	9	9
58	R:R:R117	R:R:V206	24.4209	5.23	No	Yes	3	9	9
59	R:R:L241	R:R:N203	26.3623	10.98	No	Yes	3	8	9
60	R:R:L241	R:R:V206	24.5177	2.98	No	Yes	3	8	9
61	R:R:C118	R:R:C202	18.0224	3.64	No	No	0	6	7
62	R:R:C118	R:R:S122	14.0248	3.44	No	Yes	4	6	7
63	R:R:H123	R:R:S122	10.2147	4.18	No	Yes	0	5	7
64	R:R:F184	R:R:L172	17.3269	7.31	Yes	Yes	1	6	5
65	R:R:F184	R:R:L153	13.3233	7.31	Yes	No	0	6	7
66	R:R:L153	R:R:L158	10.0091	9.69	No	No	0	7	3
67	R:R:L172	R:R:P154	23.7859	3.28	Yes	No	1	5	9
68	R:R:G159	R:R:P154	25.3583	2.03	No	No	0	8	9
69	R:R:G159	R:R:Q160	21.1612	1.64	No	No	0	8	4
70	R:R:Q160	R:R:R173	16.9519	3.5	No	No	0	4	5
71	R:R:W169	R:R:Y164	10.5473	19.29	Yes	Yes	1	7	7
72	R:R:F171	R:R:M174	11.4968	4.98	Yes	Yes	1	7	6
73	R:R:D274	R:R:Y164	10.3115	4.6	Yes	Yes	1	7	7
74	R:R:E271	R:R:W169	11.388	7.63	Yes	Yes	1	3	7
75	R:R:D274	R:R:E271	13.6196	9.09	Yes	Yes	1	7	3
76	R:R:L275	R:R:W169	11.0674	6.83	Yes	Yes	1	6	7
77	R:R:L275	R:R:R279	21.7418	8.5	Yes	Yes	1	6	8
78	R:R:L255	R:R:Y281	10.8255	15.24	No	Yes	0	6	7
79	R:R:T256	R:R:V192	21.4878	3.17	No	Yes	0	7	6
80	R:R:F260	R:R:T256	12.8273	3.89	Yes	No	0	5	7
81	R:R:F260	R:R:L186	10.9888	2.44	Yes	No	0	5	4
82	R:R:L210	R:R:V206	41.4333	2.98	Yes	Yes	0	8	9
83	R:R:L210	R:R:L238	15.3674	2.77	Yes	No	0	8	7
84	R:R:L238	R:R:T207	11.6359	7.37	No	No	0	7	7
85	R:R:E234	R:R:L210	18.7179	1.33	No	Yes	0	8	8
86	R:R:E234	R:R:Y214	15.1799	11.22	No	No	0	8	6
87	R:R:H237	R:R:R296	11.4243	2.26	No	No	0	8	8
88	R:R:D274	R:R:R258	25.6486	2.38	Yes	Yes	0	7	5
89	R:R:A277	R:R:R258	10.8316	5.53	No	Yes	0	7	5
90	R:R:G273	R:R:R258	10.8316	4.5	No	Yes	0	2	5
91	R:R:R258	R:R:T261	11.5513	2.59	Yes	No	0	5	4
92	R:R:F150	R:R:F184	15.1376	13.93	No	Yes	0	6	6
93	R:R:E271	R:R:L275	10.6199	6.63	Yes	Yes	1	3	6
94	R:R:V192	R:R:Y188	15.9782	3.79	Yes	No	1	6	8
95	R:R:S252	R:R:V192	18.5002	4.85	Yes	Yes	1	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:S20	12.44	1	Yes	No	0	7	0	1
L:L:?1	R:R:T64	5.63	1	Yes	No	0	7	0	1
L:L:?1	R:R:L67	9.7	1	Yes	No	0	7	0	1
L:L:?1	R:R:V71	7.59	1	Yes	No	0	7	0	1
L:L:?1	R:R:F95	5.43	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:S168	8.61	1	Yes	No	0	8	0	1
L:L:?1	R:R:W169	5.8	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F278	10.09	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:R279	10.06	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:Y281	2.99	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:A282	9.03	1	Yes	No	0	7	0	1
L:L:?1	R:R:P285	7.32	1	Yes	No	0	9	0	1
R:R:M23	R:R:T19	3.01	1	Yes	No	7	4	2	2
R:R:R279	R:R:T19	7.76	1	Yes	No	8	4	1	2
R:R:M23	R:R:R279	6.2	1	Yes	Yes	7	8	2	1
R:R:T64	R:R:V28	3.17	0	No	No	7	7	1	2
R:R:D60	R:R:P285	6.44	0	No	No	9	9	2	1
R:R:F95	R:R:L67	8.53	1	Yes	No	5	7	1	1
R:R:F72	R:R:V71	3.93	1	No	No	6	7	2	1
R:R:S168	R:R:V71	4.85	1	No	No	8	7	1	1
R:R:F95	R:R:L81	4.87	1	Yes	No	5	5	1	2
R:R:F95	R:R:M99	4.98	1	Yes	Yes	5	7	1	2
R:R:M99	R:R:W169	4.65	1	Yes	Yes	7	7	2	1
R:R:F171	R:R:M99	3.73	1	Yes	Yes	7	7	2	2
R:R:F278	R:R:M99	6.22	1	Yes	Yes	6	7	1	2
R:R:G103	R:R:Y281	4.35	0	No	Yes	6	7	2	1
R:R:M107	R:R:V192	4.56	1	No	Yes	8	6	2	2
R:R:M107	R:R:S252	6.13	1	No	Yes	8	8	2	2
R:R:M107	R:R:Y281	5.99	1	No	Yes	8	7	2	1
R:R:W169	R:R:Y164	19.29	1	Yes	Yes	7	7	1	2
R:R:F171	R:R:Y164	4.13	1	Yes	Yes	7	7	2	2
R:R:E271	R:R:Y164	17.96	1	Yes	Yes	3	7	2	2
R:R:P166	R:R:W169	5.4	1	No	Yes	7	7	2	1
R:R:E271	R:R:P166	11	1	Yes	No	3	7	2	2
R:R:L275	R:R:P166	13.14	1	Yes	No	6	7	2	2
R:R:F171	R:R:W169	8.02	1	Yes	Yes	7	7	2	1
R:R:E271	R:R:W169	7.63	1	Yes	Yes	3	7	2	1
R:R:L275	R:R:W169	6.83	1	Yes	Yes	6	7	2	1
R:R:F278	R:R:W169	29.06	1	Yes	Yes	6	7	1	1
R:R:F171	R:R:F278	3.22	1	Yes	Yes	7	6	2	1
R:R:V192	R:R:Y188	3.79	1	Yes	No	6	8	2	2
R:R:Y188	R:R:Y281	4.96	1	No	Yes	8	7	2	1
R:R:S252	R:R:V192	4.85	1	Yes	Yes	8	6	2	2
R:R:V192	R:R:Y281	3.79	1	Yes	Yes	6	7	2	1
R:R:S252	R:R:Y281	5.09	1	Yes	Yes	8	7	2	1
R:R:F278	R:R:L255	3.65	1	Yes	No	6	6	1	2
R:R:L255	R:R:Y281	15.24	0	No	Yes	6	7	2	1
R:R:E271	R:R:L275	6.63	1	Yes	Yes	3	6	2	2
R:R:L275	R:R:R279	8.5	1	Yes	Yes	6	8	2	1
R:R:A70	R:R:F95	2.77	0	No	Yes	5	5	2	1
R:R:S168	R:R:Y75	2.54	1	No	No	8	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8X7A_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.98
Number of Linked Nodes	265
Number of Links	303
Number of Hubs	35
Number of Links mediated by Hubs	133
Number of Communities	4
Number of Nodes involved in Communities	49
Number of Links involved in Communities	79

Path Summary
Number Of Nodes in MetaPath	96
Number Of Links MetaPath	95
Number of Shortest Paths	47719
Length Of Smallest Path	3
Average Path Length	13.0443
Length of Longest Path	31
Minimum Path Strength	1.46
Average Path Strength	5.52188
Maximum Path Strength	24.175
Minimum Path Correlation	0.7
Average Path Correlation	0.927213
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	50.6099
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.2968
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • enzyme regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • GDP binding • purine ribonucleotide binding • ion binding • anion binding • molecular function regulator activity • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • nucleoside-triphosphatase regulator activity • GTPase regulator activity • purine ribonucleoside triphosphate binding • guanyl-nucleotide exchange factor activity • nucleoside phosphate binding • purine nucleotide binding • small molecule binding • prostanoid receptor activity • prostacyclin receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • icosanoid receptor activity • prostaglandin receptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • negative regulation of signaling • negative regulation of biological process • regulation of signal transduction • regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of cell communication • cell surface receptor protein tyrosine kinase signaling pathway • negative regulation of cellular process • enzyme-linked receptor protein signaling pathway • regulation of signaling • cell surface receptor signaling pathway • negative regulation of response to stimulus • negative regulation of platelet-derived growth factor receptor signaling pathway • platelet-derived growth factor receptor signaling pathway • negative regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • defense response • response to stress • inflammatory response • negative regulation of cell population proliferation • regulation of smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • biological process involved in interspecies interaction between organisms • response to other organism • response to external stimulus • response to lipopolysaccharide • response to biotic stimulus • response to bacterium • response to external biotic stimulus • response to molecule of bacterial origin • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	Y9J
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	Y9J
Name	Treprostinil
Synonyms	Tréprostinil
Identifier
Formula	C23 H34 O5
Molecular Weight	390.513
SMILES
PubChem	6918140
Formal Charge	0
Total Atoms	62
Total Chiral Atoms	5
Total Bonds	64
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P43119
Sequence	>8X7A_nogp_Chain_R A T S T L M F V A G V V G N G L A L G I L S A R R P A R P S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N S S L L G L A R G G P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H P Y L Y A Q L D G P R C A R L A L P A I Y A F C V L F C A L P L L G L G Q H Q Q Y C P G S W C F L R M R W A Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q G E D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A P D S S S E M G D L L A F R F Y A F N P I L D P W V F I L F R K A V F Q R L K L W V C C L C L G Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9II2	C	Aminoacid	Metabotropic Glutamate	mGlu3; mGlu3	Homo sapiens	Glutamate	-	Arrestin2	3.7	2025-03-05	doi.org/10.1038/s41589-025-01858-8
	8X7A	A	Lipid	Prostanoid	I2	Homo sapiens	Treprostinil	-	Gs/β1/γ2	2.56	2024-03-06	10.1126/sciadv.adk5184
	8X7A (No Gprot)	A	Lipid	Prostanoid	I2	Homo sapiens	Treprostinil	-		2.56	2024-03-06	10.1126/sciadv.adk5184
	8X79	A	Lipid	Prostanoid	I2	Homo sapiens	MRE-269	-	Gs/β1/γ2	2.41	2024-03-06	10.1126/sciadv.adk5184
	8X79 (No Gprot)	A	Lipid	Prostanoid	I2	Homo sapiens	MRE-269	-		2.41	2024-03-06	10.1126/sciadv.adk5184
	8I2H	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	-	-	-	6	2023-03-22	10.1038/s41467-023-36170-3
	8I2G	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340	Gs/β1/γ2	2.8	2023-03-29	10.1038/s41467-023-36170-3
	8I2G (No Gprot)	A	Protein	Glycoprotein Hormone	FSH	Homo sapiens	Glycoprotein hormones α chain	Compound 716340		2.8	2023-03-29	10.1038/s41467-023-36170-3
	6LI2	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	10.1038/s41586-020-2019-0

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Download 8X7A_nogp.zip

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