psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L114	13.27	Yes	No	0	0	6
2	L:L:?1	R:R:L134	4.74	Yes	No	0	0	5
3	L:L:?1	R:R:D137	21.38	Yes	No	2	0	6
4	L:L:?1	R:R:M141	8.71	Yes	No	0	0	7
5	L:L:?1	R:R:M210	4.84	Yes	No	2	0	4
6	L:L:?1	R:R:F223	3.34	Yes	Yes	2	0	6
7	L:L:?1	R:R:F287	10.84	Yes	No	2	0	6
8	L:L:?1	R:R:Q291	7.29	Yes	No	2	0	6
9	L:L:?1	R:R:V309	5.1	Yes	No	2	0	5
10	L:L:?1	R:R:Y313	23.29	Yes	Yes	2	0	7
11	R:R:G54	R:R:S57	3.71	No	No	0	3	3
12	R:R:I64	R:R:L60	4.28	No	No	0	5	5
13	R:R:I61	R:R:Q306	6.86	No	No	0	5	4
14	R:R:L119	R:R:S62	6.01	No	No	0	4	6
15	R:R:F63	R:R:V67	6.55	No	No	0	4	5
16	R:R:I310	R:R:I64	4.42	No	No	0	4	5
17	R:R:L114	R:R:Y65	3.52	No	Yes	0	6	6
18	R:R:V115	R:R:Y65	3.79	Yes	Yes	0	6	6
19	R:R:V309	R:R:Y65	6.31	No	Yes	0	5	6
20	R:R:I310	R:R:Y65	12.09	No	Yes	0	4	6
21	R:R:C69	R:R:V111	6.83	No	No	2	5	7
22	R:R:C69	R:R:P112	3.77	No	No	2	5	8
23	R:R:C317	R:R:G72	3.92	No	No	0	7	8
24	R:R:D104	R:R:N76	6.73	Yes	Yes	1	9	9
25	R:R:E105	R:R:N76	5.26	No	Yes	0	7	9
26	R:R:M108	R:R:N76	4.21	No	Yes	0	6	9
27	R:R:N76	R:R:P320	4.89	Yes	No	1	9	9
28	R:R:F334	R:R:M78	4.98	No	No	0	5	6
29	R:R:A101	R:R:V79	3.39	No	No	0	9	9
30	R:R:R85	R:R:Y81	10.29	No	No	0	4	3
31	R:R:Y81	R:R:Y86	5.96	No	No	0	3	5
32	R:R:F334	R:R:V82	13.11	No	No	0	5	7
33	R:R:I83	R:R:L98	9.99	No	No	0	7	5
34	R:R:F330	R:R:I83	6.28	Yes	No	0	8	7
35	R:R:L84	R:R:L98	6.92	No	No	0	4	5
36	R:R:S333	R:R:Y86	8.9	No	No	0	5	5
37	R:R:R336	R:R:Y86	7.2	No	No	0	4	5
38	R:R:N94	R:R:T91	7.31	No	No	0	8	7
39	R:R:R169	R:R:T91	3.88	No	No	0	6	7
40	R:R:A92	R:R:Y96	4	No	Yes	0	5	7
41	R:R:L151	R:R:T93	4.42	No	No	0	9	8
42	R:R:F330	R:R:N94	7.25	Yes	No	0	8	8
43	R:R:A174	R:R:I95	4.87	No	No	0	7	5
44	R:R:V150	R:R:Y96	5.05	No	Yes	0	6	7
45	R:R:L151	R:R:Y96	5.86	No	Yes	0	9	7
46	R:R:D154	R:R:Y96	9.2	No	Yes	0	8	7
47	R:R:A174	R:R:Y96	4	No	Yes	0	7	7
48	R:R:V177	R:R:Y96	5.05	No	Yes	0	5	7
49	R:R:N178	R:R:Y96	6.98	No	Yes	0	8	7
50	R:R:F330	R:R:I97	5.02	Yes	No	0	8	8
51	R:R:N99	R:R:T143	4.39	Yes	No	5	9	6
52	R:R:C147	R:R:N99	7.87	No	Yes	0	8	9
53	R:R:N178	R:R:N99	9.54	No	Yes	0	8	9
54	R:R:N99	R:R:W182	10.17	Yes	No	5	9	9
55	R:R:D104	R:R:L100	8.14	Yes	No	1	9	9
56	R:R:L100	R:R:L148	5.54	No	Yes	1	9	8
57	R:R:L100	R:R:Y323	3.52	No	Yes	1	9	9
58	R:R:D104	R:R:S144	4.42	Yes	No	0	9	9
59	R:R:D104	R:R:P320	8.05	Yes	No	1	9	9
60	R:R:L106	R:R:N140	13.73	No	Yes	0	7	7
61	R:R:L107	R:R:N140	4.12	No	Yes	0	7	7
62	R:R:M108	R:R:Y313	3.59	No	Yes	0	6	7
63	R:R:C317	R:R:M108	4.86	No	No	0	7	6
64	R:R:P112	R:R:V111	3.53	No	No	2	8	7
65	R:R:V111	R:R:Y313	7.57	No	Yes	2	7	7
66	R:R:S117	R:R:W123	7.41	No	Yes	0	6	8
67	R:R:H122	R:R:L120	23.14	No	No	3	5	4
68	R:R:L120	R:R:P124	4.93	No	No	3	4	3
69	R:R:H122	R:R:P124	10.68	No	No	3	5	3
70	R:R:F125	R:R:W123	21.05	No	Yes	3	7	8
71	R:R:L129	R:R:W123	3.42	No	Yes	3	5	8
72	R:R:C130	R:R:W123	6.53	Yes	Yes	3	9	8
73	R:R:V133	R:R:W123	4.9	No	Yes	0	5	8
74	R:R:C208	R:R:W123	13.06	No	Yes	3	9	8
75	R:R:F125	R:R:P124	7.22	No	No	3	7	3
76	R:R:F125	R:R:L129	9.74	No	No	3	7	5
77	R:R:A127	R:R:T198	5.03	No	No	0	2	5
78	R:R:L128	R:R:R131	4.86	No	No	0	1	6
79	R:R:C130	R:R:L134	4.76	Yes	No	0	9	5
80	R:R:C130	R:R:T198	3.38	Yes	No	0	9	5
81	R:R:C130	R:R:C208	7.28	Yes	No	3	9	9
82	R:R:L134	R:R:S196	4.5	No	No	0	5	5
83	R:R:S135	R:R:V193	8.08	No	No	0	6	4
84	R:R:N140	R:R:V136	5.91	Yes	No	0	7	4
85	R:R:D137	R:R:Y313	5.75	No	Yes	2	6	7
86	R:R:S185	R:R:V139	4.85	No	No	0	8	5
87	R:R:I189	R:R:V139	4.61	Yes	No	0	7	5
88	R:R:M141	R:R:W284	6.98	No	Yes	0	7	8
89	R:R:F142	R:R:I145	5.02	Yes	No	4	6	7
90	R:R:F142	R:R:Y146	12.38	Yes	Yes	4	6	5
91	R:R:F142	R:R:S185	3.96	Yes	No	0	6	8
92	R:R:F142	R:R:V188	6.55	Yes	No	4	6	5
93	R:R:F142	R:R:I189	5.02	Yes	Yes	0	6	7
94	R:R:T143	R:R:W182	25.47	No	No	5	6	9
95	R:R:S185	R:R:T143	6.4	No	No	0	8	6
96	R:R:I145	R:R:Y146	4.84	No	Yes	4	7	5
97	R:R:L184	R:R:Y146	3.52	No	Yes	0	4	5
98	R:R:V188	R:R:Y146	6.31	No	Yes	4	5	5
99	R:R:M230	R:R:Y146	4.79	No	Yes	0	4	5
100	R:R:C147	R:R:V181	3.42	No	No	0	8	7
101	R:R:F280	R:R:L148	3.65	Yes	Yes	1	9	8
102	R:R:L148	R:R:N319	4.12	Yes	No	1	8	9
103	R:R:L148	R:R:Y323	5.86	Yes	Yes	1	8	9
104	R:R:P235	R:R:T149	5.25	No	No	0	9	7
105	R:R:I239	R:R:T149	7.6	No	No	0	8	7
106	R:R:L151	R:R:R155	13.36	No	Yes	0	9	9
107	R:R:I239	R:R:S152	9.29	No	No	1	8	9
108	R:R:C242	R:R:S152	3.44	No	No	0	7	9
109	R:R:S152	R:R:Y243	11.45	No	Yes	1	9	9
110	R:R:D154	R:R:R169	3.57	No	No	0	8	6
111	R:R:R155	R:R:Y243	7.2	Yes	Yes	1	9	9
112	R:R:R155	R:R:Y276	5.14	Yes	Yes	1	9	8
113	R:R:R155	R:R:Y323	6.17	Yes	Yes	1	9	9
114	R:R:V160	R:R:Y156	5.05	No	Yes	6	7	8
115	R:R:H161	R:R:Y156	8.71	No	Yes	6	7	8
116	R:R:C242	R:R:Y156	8.06	No	Yes	0	7	8
117	R:R:L245	R:R:Y156	8.21	No	Yes	0	4	8
118	R:R:H161	R:R:V160	13.84	No	No	6	7	7
119	R:R:K249	R:R:V160	6.07	No	No	0	6	7
120	R:R:R167	R:R:Y168	10.29	No	No	0	4	4
121	R:R:R170	R:R:T172	7.76	No	No	0	6	3
122	R:R:R170	R:R:V173	7.85	No	No	0	6	5
123	R:R:V188	R:R:Y226	6.31	No	No	0	5	3
124	R:R:F223	R:R:I192	5.02	Yes	No	0	6	5
125	R:R:F195	R:R:V194	3.93	Yes	No	0	5	5
126	R:R:F195	R:R:M210	3.73	Yes	No	0	5	4
127	R:R:F195	R:R:M212	12.44	Yes	No	0	5	4
128	R:R:T198	R:R:V206	4.76	No	No	0	5	4
129	R:R:N201	R:R:T205	5.85	No	No	0	3	3
130	R:R:F223	R:R:M210	11.2	Yes	No	2	6	4
131	R:R:M212	R:R:W219	5.82	No	No	0	4	2
132	R:R:E214	R:R:P215	4.72	No	No	0	5	2
133	R:R:E214	R:R:W219	16.36	No	No	0	5	2
134	R:R:L220	R:R:V295	8.94	No	No	0	5	4
135	R:R:F223	R:R:T227	7.78	Yes	No	0	6	5
136	R:R:V224	R:R:V295	4.81	No	No	0	5	4
137	R:R:M230	R:R:Y226	13.17	No	No	0	4	3
138	R:R:T227	R:R:Y288	6.24	No	No	0	5	7
139	R:R:F228	R:R:F232	4.29	No	Yes	0	5	8
140	R:R:F228	R:R:L233	8.53	No	No	0	5	4
141	R:R:F228	R:R:Y288	15.47	No	No	0	5	7
142	R:R:L229	R:R:L234	4.15	No	No	0	4	4
143	R:R:G231	R:R:P235	4.06	No	No	0	5	9
144	R:R:F232	R:R:V236	10.49	Yes	No	0	8	6
145	R:R:F232	R:R:V281	7.87	Yes	No	0	8	5
146	R:R:F232	R:R:M285	7.46	Yes	No	0	8	5
147	R:R:L234	R:R:P235	3.28	No	No	0	4	9
148	R:R:I239	R:R:Y243	4.84	No	Yes	1	8	9
149	R:R:C240	R:R:V277	3.42	No	No	0	4	7
150	R:R:L241	R:R:L245	4.15	No	No	0	4	4
151	R:R:V273	R:R:Y243	12.62	No	Yes	0	7	9
152	R:R:Y243	R:R:Y276	9.93	Yes	Yes	1	9	8
153	R:R:I247	R:R:R251	6.26	No	No	0	5	5
154	R:R:E266	R:R:M250	17.59	No	No	7	6	8
155	R:R:I269	R:R:M250	5.83	No	No	7	7	8
156	R:R:K263	R:R:W259	3.48	No	No	0	2	3
157	R:R:K263	R:R:Q260	12.2	No	No	0	2	1
158	R:R:Q261	R:R:R262	5.84	No	No	0	3	3
159	R:R:R264	R:R:R267	12.79	No	No	0	4	4
160	R:R:E266	R:R:I269	4.1	No	No	7	6	7
161	R:R:M272	R:R:Y276	9.58	No	Yes	0	8	8
162	R:R:L326	R:R:M272	5.65	No	No	0	6	8
163	R:R:Y276	R:R:Y323	30.78	Yes	Yes	1	8	9
164	R:R:F280	R:R:W284	19.04	Yes	Yes	1	9	8
165	R:R:F280	R:R:N315	7.25	Yes	Yes	1	9	9
166	R:R:F280	R:R:N319	3.62	Yes	No	1	9	9
167	R:R:C283	R:R:L311	9.52	No	No	0	9	7
168	R:R:C283	R:R:N315	9.45	No	Yes	0	9	9
169	R:R:N315	R:R:W284	15.82	Yes	Yes	1	9	8
170	R:R:M285	R:R:P286	3.35	No	No	0	5	9
171	R:R:F287	R:R:Q291	5.86	No	No	2	6	6
172	R:R:F287	R:R:S308	3.96	No	No	0	6	6
173	R:R:V290	R:R:V304	4.81	Yes	No	0	4	4
174	R:R:S308	R:R:V290	4.85	No	Yes	0	6	4
175	R:R:E298	R:R:N294	5.26	No	No	0	1	4
176	R:R:E298	R:R:Q299	3.82	No	No	0	1	1
177	R:R:D301	R:R:E298	12.99	No	No	0	4	1
178	R:R:V309	R:R:Y313	3.79	No	Yes	2	5	7
179	R:R:N315	R:R:N319	12.26	Yes	No	1	9	9
180	R:R:F325	R:R:I321	8.79	No	No	0	6	7
181	R:R:F325	R:R:F334	7.5	No	No	0	6	5
182	R:R:N329	R:R:S327	8.94	No	No	0	7	8
183	R:R:F330	R:R:N329	12.08	Yes	No	0	8	7
184	R:R:A101	R:R:I80	3.25	No	No	0	9	7
185	R:R:A138	R:R:I189	3.25	No	Yes	0	4	7
186	R:R:C74	R:R:M78	3.24	No	No	0	4	6
187	R:R:S62	R:R:V115	3.23	No	Yes	0	6	6
188	R:R:S333	R:R:V82	3.23	No	No	0	5	7
189	R:R:R262	R:R:R264	3.2	No	No	0	3	4
190	R:R:C69	R:R:L73	3.17	No	No	0	5	6
191	R:R:T303	R:R:V304	3.17	No	No	0	2	4
192	R:R:A199	R:R:L211	3.15	No	No	0	3	4
193	R:R:I83	R:R:V79	3.07	No	No	0	7	9
194	R:R:I189	R:R:V193	3.07	Yes	No	0	7	4
195	R:R:K249	R:R:V253	3.04	No	No	0	6	6
196	R:R:M275	R:R:V279	3.04	No	No	0	6	7
197	R:R:L107	R:R:S316	3	No	No	0	7	8
198	R:R:L132	R:R:V136	2.98	No	No	0	4	4
199	R:R:L187	R:R:V183	2.98	No	No	0	2	3
200	R:R:L225	R:R:V221	2.98	No	No	0	5	2
201	R:R:L292	R:R:V224	2.98	No	No	0	5	5
202	R:R:L322	R:R:V279	2.98	No	No	0	8	7
203	R:R:N140	R:R:V139	2.96	Yes	No	0	7	5
204	R:R:N294	R:R:V290	2.96	No	Yes	0	4	4
205	R:R:I102	R:R:I80	2.94	No	No	0	7	7
206	R:R:I95	R:R:M89	2.92	No	No	0	5	6
207	R:R:I247	R:R:M250	2.92	No	No	0	5	8
208	R:R:F195	R:R:P191	2.89	Yes	No	0	5	6
209	R:R:F195	R:R:P213	2.89	Yes	No	0	5	4
210	R:R:I189	R:R:L186	2.85	Yes	No	0	7	3
211	R:R:G126	R:R:W123	2.81	No	Yes	0	7	8
212	R:R:G312	R:R:W284	2.81	No	Yes	0	7	8
213	R:R:K88	R:R:N94	2.8	No	No	0	6	8
214	R:R:L109	R:R:L73	2.77	No	No	0	5	6
215	R:R:L211	R:R:N209	2.75	No	No	0	4	5
216	R:R:H122	R:R:T205	2.74	No	No	0	5	3
217	R:R:R131	R:R:S196	2.64	No	No	0	6	5
218	R:R:F325	R:R:V79	2.62	No	No	0	6	9
219	R:R:F330	R:R:V82	2.62	Yes	No	0	8	7
220	R:R:D300	R:R:Q299	2.61	No	No	0	4	1
221	R:R:R251	R:R:T270	2.59	No	No	0	5	7
222	R:R:K164	R:R:R167	2.48	No	No	0	4	4
223	R:R:F296	R:R:L292	2.44	No	No	0	4	5
224	R:R:L271	R:R:R267	2.43	No	No	0	6	4
225	R:R:I61	R:R:Y65	2.42	No	Yes	0	5	6
226	R:R:I246	R:R:Y156	2.42	No	Yes	0	9	8
227	R:R:I246	R:R:Y243	2.42	No	Yes	0	9	9
228	R:R:L322	R:R:Y276	2.34	No	Yes	0	8	8
229	L:L:?1	R:R:S110	2.06	Yes	No	0	0	6
230	R:R:C74	R:R:G75	1.96	No	No	0	4	8
231	L:L:?1	R:R:L220	1.9	Yes	No	0	0	5
232	L:L:?1	R:R:N209	1.88	Yes	No	0	0	5
233	R:R:G324	R:R:S327	1.86	No	No	0	7	8
234	R:R:G72	R:R:V71	1.84	No	No	0	8	5
235	R:R:G180	R:R:V183	1.84	No	No	0	4	3
236	R:R:G56	R:R:I59	1.76	No	No	0	1	5
237	R:R:C317	R:R:V68	1.71	No	No	0	7	7
238	R:R:A103	R:R:S144	1.71	No	No	0	8	9
239	R:R:C242	R:R:V153	1.71	No	No	0	7	6
240	R:R:C240	R:R:V244	1.71	No	No	0	4	4
241	R:R:A165	R:R:V157	1.7	No	No	0	6	5
242	R:R:A158	R:R:V159	1.7	No	No	0	8	8
243	R:R:A200	R:R:V206	1.7	No	No	0	1	4
244	R:R:I95	R:R:P171	1.69	No	No	0	5	3
245	R:R:A238	R:R:T149	1.68	No	No	0	6	7
246	R:R:G56	R:R:Q55	1.64	No	No	0	1	4
247	R:R:L190	R:R:P191	1.64	No	No	0	3	6
248	R:R:S66	R:R:V115	1.62	No	Yes	0	5	6
249	R:R:S305	R:R:V290	1.62	No	Yes	0	4	4
250	R:R:S62	R:R:T118	1.6	No	No	0	6	4
251	R:R:V67	R:R:V71	1.6	No	No	0	5	5
252	R:R:V153	R:R:V157	1.6	No	No	0	6	5
253	R:R:V173	R:R:V177	1.6	No	No	0	5	5
254	R:R:V221	R:R:V295	1.6	No	No	0	2	4
255	R:R:V277	R:R:V281	1.6	No	No	0	7	5
256	R:R:V289	R:R:V293	1.6	No	No	0	6	5
257	R:R:T116	R:R:V115	1.59	No	Yes	0	4	6
258	R:R:A216	R:R:L220	1.58	No	No	0	3	5
259	R:R:I246	R:R:V159	1.54	No	No	0	9	8
260	R:R:I247	R:R:V273	1.54	No	No	0	5	7
261	R:R:M78	R:R:S77	1.53	No	No	0	6	4
262	R:R:M278	R:R:V277	1.52	No	No	0	5	7
263	R:R:M285	R:R:V289	1.52	No	No	0	5	6
264	R:R:A254	R:R:E266	1.51	No	No	0	4	6
265	R:R:M274	R:R:T270	1.51	No	No	0	5	7
266	R:R:L179	R:R:V183	1.49	No	No	0	4	3
267	R:R:I282	R:R:M278	1.46	No	No	0	5	5
268	R:R:I163	R:R:K164	1.45	No	No	0	6	4
269	R:R:K268	R:R:M272	1.44	No	No	0	7	8
270	R:R:A58	R:R:R121	1.38	No	No	0	4	4
271	R:R:L187	R:R:L190	1.38	No	No	0	2	3
272	R:R:F113	R:R:V133	1.31	No	No	0	5	5
273	R:R:H161	R:R:K164	1.31	No	No	0	7	4
274	R:R:R121	R:R:T118	1.29	No	No	0	4	4
275	R:R:R267	R:R:T270	1.29	No	No	0	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	8.35692	13	2	0
2	R:R:Y65	5.626	5	0	6
3	R:R:N76	5.2725	4	1	9
4	R:R:Y96	5.73429	7	0	7
5	R:R:N99	7.9925	4	5	9
6	R:R:D104	6.835	4	1	9
7	R:R:V115	2.5575	4	0	6
8	R:R:W123	8.45429	7	3	8
9	R:R:C130	5.4875	4	3	9
10	R:R:N140	6.68	4	0	7
11	R:R:F142	6.586	5	4	6
12	R:R:Y146	6.368	5	4	5
13	R:R:L148	4.7925	4	1	8
14	R:R:R155	7.9675	4	1	9
15	R:R:Y156	6.49	5	6	8
16	R:R:I189	3.76	5	0	7
17	R:R:F195	5.176	5	0	5
18	R:R:F223	6.835	4	2	6
19	R:R:F232	7.5275	4	0	8
20	R:R:Y243	8.07667	6	1	9
21	R:R:Y276	11.554	5	1	8
22	R:R:F280	8.39	4	1	9
23	R:R:W284	11.1625	4	1	8
24	R:R:V290	3.56	4	0	4
25	R:R:Y313	8.798	5	2	7
26	R:R:N315	11.195	4	1	9
27	R:R:Y323	11.5825	4	1	9
28	R:R:F330	6.65	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L114	18.8038	13.27	Yes	No	0	0	6
2	R:R:L114	R:R:Y65	17.6125	3.52	No	Yes	0	6	6
3	R:R:I310	R:R:Y65	10.5981	12.09	No	Yes	0	4	6
4	L:L:?1	R:R:V309	18.7593	5.1	Yes	No	2	0	5
5	R:R:V309	R:R:Y65	30.5882	6.31	No	Yes	0	5	6
6	R:R:V115	R:R:Y65	27.9041	3.79	Yes	Yes	0	6	6
7	R:R:S62	R:R:V115	17.6174	3.23	No	Yes	0	6	6
8	R:R:M108	R:R:Y313	25.4968	3.59	No	Yes	0	6	7
9	R:R:M108	R:R:N76	27.8497	4.21	No	Yes	0	6	9
10	R:R:D104	R:R:N76	27.998	6.73	Yes	Yes	1	9	9
11	L:L:?1	R:R:M141	96.4113	8.71	Yes	No	0	0	7
12	R:R:M141	R:R:W284	96.7672	6.98	No	Yes	0	7	8
13	R:R:F280	R:R:W284	94.8542	19.04	Yes	Yes	1	9	8
14	R:R:F280	R:R:L148	97.1379	3.65	Yes	Yes	1	9	8
15	R:R:L148	R:R:Y323	100	5.86	Yes	Yes	1	8	9
16	R:R:R155	R:R:Y323	92.2541	6.17	Yes	Yes	1	9	9
17	R:R:L151	R:R:R155	77.9239	13.36	No	Yes	0	9	9
18	R:R:L151	R:R:Y96	76.5991	5.86	No	Yes	0	9	7
19	R:R:D154	R:R:Y96	39.738	9.2	No	Yes	0	8	7
20	R:R:D154	R:R:R169	38.6505	3.57	No	No	0	8	6
21	R:R:R169	R:R:T91	37.5482	3.88	No	No	0	6	7
22	R:R:N94	R:R:T91	36.436	7.31	No	No	0	8	7
23	R:R:F330	R:R:N94	34.172	7.25	Yes	No	0	8	8
24	R:R:F330	R:R:V82	17.1132	2.62	Yes	No	0	8	7
25	R:R:F330	R:R:I83	11.9229	6.28	Yes	No	0	8	7
26	R:R:N178	R:R:Y96	38.6505	6.98	No	Yes	0	8	7
27	R:R:N178	R:R:N99	37.5482	9.54	No	Yes	0	8	9
28	R:R:N99	R:R:T143	32.9115	4.39	Yes	No	5	9	6
29	R:R:D104	R:R:L100	29.8912	8.14	Yes	No	1	9	9
30	R:R:S185	R:R:T143	31.8883	6.4	No	No	0	8	6
31	R:R:S185	R:R:V139	15.6599	4.85	No	No	0	8	5
32	L:L:?1	R:R:L134	30.6871	4.74	Yes	No	0	0	5
33	R:R:C130	R:R:L134	25.6599	4.76	Yes	No	0	9	5
34	R:R:C130	R:R:W123	17.3554	6.53	Yes	Yes	3	9	8
35	R:R:F142	R:R:S185	15.5462	3.96	Yes	No	0	6	8
36	R:R:R155	R:R:Y243	47.6075	7.2	Yes	Yes	1	9	9
37	R:R:I239	R:R:Y243	14.9086	4.84	No	Yes	1	8	9
38	R:R:I239	R:R:T149	13.2823	7.6	No	No	0	8	7
39	R:R:Y276	R:R:Y323	37.4394	30.78	Yes	Yes	1	8	9
40	R:R:Y243	R:R:Y276	33.3366	9.93	Yes	Yes	1	9	8
41	R:R:S152	R:R:Y243	10.3164	11.45	No	Yes	1	9	9
42	R:R:I246	R:R:Y243	29.2388	2.42	No	Yes	0	9	9
43	R:R:I246	R:R:Y156	23.2724	2.42	No	Yes	0	9	8
44	R:R:H161	R:R:Y156	10.9194	8.71	No	Yes	6	7	8
45	L:L:?1	R:R:M210	18.8384	4.84	Yes	No	2	0	4
46	R:R:F195	R:R:M210	18.8235	3.73	Yes	No	0	5	4
47	L:L:?1	R:R:F223	24.2956	3.34	Yes	Yes	2	0	6
48	R:R:F223	R:R:T227	23.0895	7.78	Yes	No	0	6	5
49	L:L:?1	R:R:L220	11.5818	1.9	Yes	No	0	0	5
50	R:R:T227	R:R:Y288	21.7202	6.24	No	No	0	5	7
51	R:R:F228	R:R:Y288	20.3411	15.47	No	No	0	5	7
52	R:R:F228	R:R:F232	17.5531	4.29	No	Yes	0	5	8
53	R:R:V273	R:R:Y243	29.4661	12.62	No	Yes	0	7	9
54	R:R:I247	R:R:V273	27.395	1.54	No	No	0	5	7
55	R:R:I247	R:R:R251	17.1824	6.26	No	No	0	5	5
56	R:R:R251	R:R:T270	15.0667	2.59	No	No	0	5	7
57	R:R:R267	R:R:T270	10.8206	1.29	No	No	0	4	7
58	L:L:?1	R:R:F287	16.001	10.84	Yes	No	2	0	6
59	R:R:F287	R:R:S308	14.7257	3.96	No	No	0	6	6
60	R:R:S308	R:R:V290	13.2971	4.85	No	Yes	0	6	4
61	R:R:S62	R:R:T118	10.5882	1.6	No	No	0	6	4
62	R:R:V309	R:R:Y313	13.8903	3.79	No	Yes	2	5	7
63	R:R:L100	R:R:Y323	29.6738	3.52	No	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L114	13.27	2	Yes	No	0	6	0	1
L:L:?1	R:R:L134	4.74	2	Yes	No	0	5	0	1
L:L:?1	R:R:D137	21.38	2	Yes	No	0	6	0	1
L:L:?1	R:R:M141	8.71	2	Yes	No	0	7	0	1
L:L:?1	R:R:M210	4.84	2	Yes	No	0	4	0	1
L:L:?1	R:R:F223	3.34	2	Yes	Yes	0	6	0	1
L:L:?1	R:R:F287	10.84	2	Yes	No	0	6	0	1
L:L:?1	R:R:Q291	7.29	2	Yes	No	0	6	0	1
L:L:?1	R:R:V309	5.1	2	Yes	No	0	5	0	1
L:L:?1	R:R:Y313	23.29	2	Yes	Yes	0	7	0	1
R:R:L114	R:R:Y65	3.52	0	No	Yes	6	6	1	2
R:R:V309	R:R:Y65	6.31	2	No	Yes	5	6	1	2
R:R:M108	R:R:Y313	3.59	0	No	Yes	6	7	2	1
R:R:V111	R:R:Y313	7.57	2	No	Yes	7	7	2	1
R:R:C130	R:R:L134	4.76	3	Yes	No	9	5	2	1
R:R:L134	R:R:S196	4.5	0	No	No	5	5	1	2
R:R:D137	R:R:Y313	5.75	2	No	Yes	6	7	1	1
R:R:M141	R:R:W284	6.98	0	No	Yes	7	8	1	2
R:R:F223	R:R:I192	5.02	2	Yes	No	6	5	1	2
R:R:F195	R:R:M210	3.73	0	Yes	No	5	4	2	1
R:R:F223	R:R:M210	11.2	2	Yes	No	6	4	1	1
R:R:L220	R:R:V295	8.94	0	No	No	5	4	1	2
R:R:F223	R:R:T227	7.78	2	Yes	No	6	5	1	2
R:R:F287	R:R:Q291	5.86	2	No	No	6	6	1	1
R:R:F287	R:R:S308	3.96	2	No	No	6	6	1	2
R:R:V309	R:R:Y313	3.79	2	No	Yes	5	7	1	1
R:R:L211	R:R:N209	2.75	0	No	No	4	5	2	1
L:L:?1	R:R:S110	2.06	2	Yes	No	0	6	0	1
L:L:?1	R:R:L220	1.9	2	Yes	No	0	5	0	1
L:L:?1	R:R:N209	1.88	2	Yes	No	0	5	0	1
R:R:A216	R:R:L220	1.58	0	No	No	3	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XIO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.28
Number of Linked Nodes	252
Number of Links	275
Number of Hubs	28
Number of Links mediated by Hubs	121
Number of Communities	7
Number of Nodes involved in Communities	47
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	42906
Length Of Smallest Path	3
Average Path Length	13.5747
Length of Longest Path	28
Minimum Path Strength	1.335
Average Path Strength	6.89172
Maximum Path Strength	20.355
Minimum Path Correlation	0.7
Average Path Correlation	0.920531
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	44.192
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.6234
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cell surface receptor signaling pathway • glutamate receptor signaling pathway • cerebellum development • metencephalon development • hindbrain development • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1D
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30872
Sequence	>8XIO_nogp_Chain_R E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y A K M K T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L R H W P F G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H P I K A A R Y R R P T V A K V V N L G V W V L S L L V I L P I V V F S R T A A N S D G T V A C N M L M P E P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G W Q Q R K R S E R K I T L M V M M V M V F V I C W M P F Y V V Q L V N V F A E Q D D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F K R S F Q R Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIP	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-		3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-		2.65	2024-07-03	doi.org/10.1073/pnas.2400298121

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XIO_nogp.zip

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