psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	16.88	Yes	Yes	1	0	0
2	L:L:?1	L:L:?4	10.1	Yes	Yes	1	0	0
3	L:L:?1	L:L:?6	25.42	Yes	Yes	1	0	0
4	L:L:?1	R:R:N209	6.66	Yes	No	1	0	5
5	L:L:?1	R:R:M210	5.71	Yes	No	1	0	4
6	L:L:?1	R:R:L220	3.36	Yes	No	0	0	5
7	L:L:?2	L:L:K3	27.98	Yes	Yes	1	0	0
8	L:L:?2	L:L:?4	3.61	Yes	Yes	1	0	0
9	L:L:?2	R:R:M141	3.37	Yes	No	0	0	7
10	L:L:?2	R:R:M210	7.85	Yes	No	1	0	4
11	L:L:?2	R:R:Q291	7.4	Yes	No	0	0	6
12	L:L:?4	L:L:K3	4.63	Yes	Yes	1	0	0
13	L:L:K3	R:R:D137	11.06	Yes	Yes	1	0	6
14	L:L:K3	R:R:Y313	9.55	Yes	Yes	1	0	7
15	L:L:?4	L:L:?6	5.16	Yes	Yes	1	0	0
16	L:L:?4	R:R:L114	18.17	Yes	No	0	0	6
17	L:L:?4	R:R:S117	8.62	Yes	No	0	0	6
18	L:L:?4	R:R:L134	7.95	Yes	No	0	0	5
19	L:L:?4	R:R:D137	10.02	Yes	Yes	1	0	6
20	L:L:?4	R:R:N209	4.51	Yes	No	1	0	5
21	L:L:?6	L:L:F5	11.07	Yes	No	0	0	0
22	L:L:F5	R:R:S305	5.28	No	Yes	0	0	4
23	L:L:F5	R:R:Q306	5.86	No	No	0	0	4
24	L:L:?6	R:R:D300	4.62	Yes	No	0	0	4
25	R:R:Q55	R:R:S52	4.33	No	No	0	4	3
26	R:R:I64	R:R:L60	4.28	No	No	0	5	5
27	R:R:I61	R:R:Q306	5.49	No	No	0	5	4
28	R:R:L119	R:R:S62	6.01	No	No	0	4	6
29	R:R:F63	R:R:V67	6.55	No	No	0	4	5
30	R:R:I310	R:R:I64	4.42	No	No	0	4	5
31	R:R:L114	R:R:Y65	3.52	No	Yes	0	6	6
32	R:R:V309	R:R:Y65	7.57	No	Yes	0	5	6
33	R:R:I310	R:R:Y65	12.09	No	Yes	0	4	6
34	R:R:C69	R:R:V111	6.83	No	Yes	1	5	7
35	R:R:C69	R:R:P112	3.77	No	No	1	5	8
36	R:R:G72	R:R:M108	3.49	No	Yes	1	8	6
37	R:R:C317	R:R:G72	3.92	No	No	1	7	8
38	R:R:E105	R:R:L73	10.6	Yes	No	0	7	6
39	R:R:D104	R:R:N76	6.73	Yes	No	4	9	9
40	R:R:E105	R:R:N76	6.57	Yes	No	0	7	9
41	R:R:N76	R:R:P320	4.89	No	No	4	9	9
42	R:R:E105	R:R:S77	4.31	Yes	No	0	7	4
43	R:R:I83	R:R:V79	3.07	No	No	0	7	9
44	R:R:A101	R:R:V79	3.39	No	No	0	9	9
45	R:R:R85	R:R:Y81	15.43	No	No	0	4	3
46	R:R:V82	R:R:Y86	3.79	No	No	5	7	5
47	R:R:S333	R:R:V82	3.23	No	No	5	5	7
48	R:R:F334	R:R:V82	6.55	No	No	0	5	7
49	R:R:I83	R:R:L98	9.99	No	No	0	7	5
50	R:R:S333	R:R:Y86	8.9	No	No	5	5	5
51	R:R:F330	R:R:K88	3.72	Yes	No	0	8	6
52	R:R:K88	R:R:S333	7.65	No	No	0	6	5
53	R:R:T91	R:R:T93	4.71	No	No	0	7	8
54	R:R:N94	R:R:T91	8.77	No	No	0	8	7
55	R:R:A174	R:R:I95	6.5	No	No	0	7	5
56	R:R:I95	R:R:K175	5.82	No	No	0	5	3
57	R:R:V150	R:R:Y96	8.83	No	Yes	6	6	7
58	R:R:L151	R:R:Y96	5.86	No	Yes	0	9	7
59	R:R:D154	R:R:Y96	5.75	No	Yes	0	8	7
60	R:R:A174	R:R:Y96	4	No	Yes	0	7	7
61	R:R:V177	R:R:Y96	3.79	No	Yes	6	5	7
62	R:R:N178	R:R:Y96	5.81	No	Yes	0	8	7
63	R:R:N99	R:R:T143	4.39	Yes	Yes	7	9	6
64	R:R:C147	R:R:N99	7.87	No	Yes	0	8	9
65	R:R:N178	R:R:N99	10.9	No	Yes	0	8	9
66	R:R:N99	R:R:W182	9.04	Yes	No	7	9	9
67	R:R:D104	R:R:L100	6.79	Yes	No	0	9	9
68	R:R:L100	R:R:L148	5.54	No	No	0	9	8
69	R:R:A103	R:R:T143	3.36	No	Yes	0	8	6
70	R:R:D104	R:R:S144	5.89	Yes	No	0	9	9
71	R:R:D104	R:R:S316	4.42	Yes	No	0	9	8
72	R:R:D104	R:R:P320	3.22	Yes	No	4	9	9
73	R:R:E105	R:R:L109	3.98	Yes	No	0	7	5
74	R:R:L106	R:R:N140	4.12	No	No	0	7	7
75	R:R:L107	R:R:M108	4.24	No	Yes	0	7	6
76	R:R:L107	R:R:N140	9.61	No	No	0	7	7
77	R:R:L107	R:R:Y313	11.72	No	Yes	0	7	7
78	R:R:M108	R:R:V111	3.04	Yes	Yes	1	6	7
79	R:R:C317	R:R:M108	3.24	No	Yes	1	7	6
80	R:R:D137	R:R:S110	4.42	Yes	No	0	6	6
81	R:R:P112	R:R:V111	3.53	No	Yes	1	8	7
82	R:R:V111	R:R:Y313	3.79	Yes	Yes	1	7	7
83	R:R:F113	R:R:W123	6.01	No	Yes	8	5	8
84	R:R:F113	R:R:V133	15.73	No	No	8	5	5
85	R:R:S117	R:R:W123	6.18	No	Yes	0	6	8
86	R:R:H122	R:R:P124	3.05	No	No	0	5	3
87	R:R:H122	R:R:T205	5.48	No	No	0	5	3
88	R:R:F125	R:R:W123	17.04	No	Yes	0	7	8
89	R:R:C130	R:R:W123	9.14	No	Yes	0	9	8
90	R:R:V133	R:R:W123	3.68	No	Yes	8	5	8
91	R:R:F125	R:R:L129	4.87	No	No	0	7	5
92	R:R:A127	R:R:T198	5.03	No	No	0	2	5
93	R:R:C130	R:R:T198	3.38	No	No	0	9	5
94	R:R:C130	R:R:C208	7.28	No	No	0	9	9
95	R:R:R131	R:R:R197	15.99	No	No	0	6	4
96	R:R:L134	R:R:S196	7.51	No	No	0	5	5
97	R:R:C208	R:R:L134	3.17	No	No	0	9	5
98	R:R:S135	R:R:V193	6.46	No	No	0	6	4
99	R:R:D137	R:R:Y313	3.45	Yes	Yes	1	6	7
100	R:R:A138	R:R:I189	4.87	No	Yes	0	4	7
101	R:R:I189	R:R:V139	3.07	Yes	No	0	7	5
102	R:R:I145	R:R:M141	4.37	No	No	0	7	7
103	R:R:M141	R:R:W284	8.14	No	Yes	0	7	8
104	R:R:F142	R:R:Y146	4.13	No	No	0	6	5
105	R:R:F142	R:R:V188	3.93	No	No	0	6	5
106	R:R:F142	R:R:I189	5.02	No	Yes	0	6	7
107	R:R:T143	R:R:W182	18.19	Yes	No	7	6	9
108	R:R:S185	R:R:T143	4.8	No	Yes	0	8	6
109	R:R:I145	R:R:P235	3.39	No	Yes	0	7	9
110	R:R:F280	R:R:I145	3.77	No	No	0	9	7
111	R:R:S185	R:R:Y146	6.36	No	No	0	8	5
112	R:R:L148	R:R:N319	8.24	No	No	2	8	9
113	R:R:L148	R:R:Y323	9.38	No	Yes	2	8	9
114	R:R:P235	R:R:T149	3.5	Yes	No	0	9	7
115	R:R:I239	R:R:T149	3.04	No	No	0	8	7
116	R:R:V150	R:R:V177	4.81	No	No	6	6	5
117	R:R:L151	R:R:R155	12.15	No	Yes	0	9	9
118	R:R:I239	R:R:S152	10.84	No	No	0	8	9
119	R:R:S152	R:R:Y243	5.09	No	Yes	0	9	9
120	R:R:D154	R:R:R169	9.53	No	No	0	8	6
121	R:R:R155	R:R:Y243	6.17	Yes	Yes	2	9	9
122	R:R:R155	R:R:Y276	6.17	Yes	Yes	2	9	8
123	R:R:R155	R:R:Y323	5.14	Yes	Yes	2	9	9
124	R:R:V160	R:R:Y156	8.83	Yes	Yes	11	7	8
125	R:R:H161	R:R:Y156	7.62	No	Yes	11	7	8
126	R:R:C242	R:R:Y156	9.41	No	Yes	0	7	8
127	R:R:L245	R:R:Y156	7.03	No	Yes	0	4	8
128	R:R:V157	R:R:Y168	3.79	No	No	0	5	4
129	R:R:A158	R:R:R169	5.53	No	No	0	8	6
130	R:R:I246	R:R:V159	3.07	No	No	0	9	8
131	R:R:H161	R:R:V160	4.15	No	Yes	11	7	7
132	R:R:I246	R:R:V160	3.07	No	Yes	0	9	7
133	R:R:K164	R:R:Y168	13.14	No	No	0	4	4
134	R:R:R167	R:R:Y168	12.35	No	No	0	4	4
135	R:R:R170	R:R:T172	5.17	No	No	0	6	3
136	R:R:R170	R:R:V173	3.92	No	No	0	6	5
137	R:R:F223	R:R:I192	10.05	No	No	0	6	5
138	R:R:L211	R:R:R197	6.07	No	No	0	4	4
139	R:R:D203	R:R:N201	4.04	No	No	9	4	3
140	R:R:N201	R:R:T205	4.39	No	No	9	3	3
141	R:R:A207	R:R:N201	4.69	No	No	0	5	3
142	R:R:D203	R:R:T205	10.12	No	No	9	4	3
143	R:R:A207	R:R:N209	3.13	No	No	0	5	5
144	R:R:F223	R:R:M210	6.22	No	No	0	6	4
145	R:R:M212	R:R:P213	5.03	No	Yes	0	4	4
146	R:R:L220	R:R:M212	7.07	No	No	0	5	4
147	R:R:P213	R:R:P215	3.9	Yes	Yes	12	4	2
148	R:R:P213	R:R:W219	5.4	Yes	No	12	4	2
149	R:R:E214	R:R:P215	3.14	No	Yes	0	5	2
150	R:R:P215	R:R:W219	9.46	Yes	No	12	2	2
151	R:R:L220	R:R:V295	5.96	No	No	0	5	4
152	R:R:F223	R:R:T227	7.78	No	No	0	6	5
153	R:R:V224	R:R:V295	3.21	No	No	0	5	4
154	R:R:M230	R:R:Y226	4.79	No	No	0	4	3
155	R:R:F228	R:R:F232	3.22	No	Yes	0	5	8
156	R:R:F228	R:R:Y288	13.41	No	No	0	5	7
157	R:R:L229	R:R:L233	5.54	No	No	0	4	4
158	R:R:L234	R:R:M230	7.07	No	No	0	4	4
159	R:R:G231	R:R:P235	4.06	No	Yes	0	5	9
160	R:R:F232	R:R:V236	3.93	Yes	No	0	8	6
161	R:R:F232	R:R:M285	6.22	Yes	Yes	0	8	5
162	R:R:L234	R:R:P235	3.28	No	Yes	0	4	9
163	R:R:C240	R:R:V277	5.12	No	No	0	4	7
164	R:R:L241	R:R:L245	4.15	No	No	0	4	4
165	R:R:V273	R:R:Y243	12.62	No	Yes	0	7	9
166	R:R:Y243	R:R:Y276	4.96	Yes	Yes	2	9	8
167	R:R:I247	R:R:R251	6.26	No	No	0	5	5
168	R:R:K249	R:R:M252	4.32	No	No	0	6	5
169	R:R:K249	R:R:V253	6.07	No	No	0	6	6
170	R:R:E266	R:R:M250	13.53	No	No	0	6	8
171	R:R:G258	R:R:Q261	3.29	No	No	0	2	3
172	R:R:Q260	R:R:W259	8.76	No	No	0	1	3
173	R:R:Q260	R:R:R264	3.5	No	No	0	1	4
174	R:R:R264	R:R:R267	10.66	No	No	0	4	4
175	R:R:K268	R:R:S265	3.06	No	No	0	7	5
176	R:R:E266	R:R:T270	8.47	No	No	0	6	7
177	R:R:M272	R:R:Y276	7.18	No	Yes	0	8	8
178	R:R:L326	R:R:M272	4.24	No	No	0	6	8
179	R:R:L322	R:R:Y276	5.86	No	Yes	0	8	8
180	R:R:Y276	R:R:Y323	17.87	Yes	Yes	2	8	9
181	R:R:I282	R:R:M278	4.37	No	No	0	5	5
182	R:R:F280	R:R:W284	18.04	No	Yes	10	9	8
183	R:R:F280	R:R:N315	7.25	No	Yes	10	9	9
184	R:R:M285	R:R:V281	4.56	Yes	No	0	5	5
185	R:R:C283	R:R:L311	7.94	No	No	0	9	7
186	R:R:C283	R:R:N315	9.45	No	Yes	0	9	9
187	R:R:N315	R:R:W284	10.17	Yes	Yes	10	9	8
188	R:R:M285	R:R:P286	3.35	Yes	No	0	5	9
189	R:R:F287	R:R:Y288	4.13	No	No	0	6	7
190	R:R:F287	R:R:Q291	15.23	No	No	0	6	6
191	R:R:F287	R:R:S308	9.25	No	No	0	6	6
192	R:R:N294	R:R:V290	4.43	No	No	3	4	4
193	R:R:S305	R:R:V290	3.23	Yes	No	3	4	4
194	R:R:N294	R:R:S305	4.47	No	Yes	3	4	4
195	R:R:Q306	R:R:T303	4.25	No	No	0	4	2
196	R:R:V309	R:R:Y313	6.31	No	Yes	0	5	7
197	R:R:N319	R:R:Y323	4.65	No	Yes	2	9	9
198	R:R:F325	R:R:I321	7.54	No	No	0	6	7
199	R:R:F330	R:R:G324	4.52	Yes	No	0	8	7
200	R:R:F325	R:R:F334	5.36	No	No	0	6	5
201	R:R:F330	R:R:S327	5.28	Yes	No	0	8	8
202	R:R:D328	R:R:N329	8.08	No	No	0	5	7
203	R:R:F330	R:R:F334	4.29	Yes	No	0	8	5
204	R:R:L119	R:R:V115	2.98	No	No	0	4	6
205	R:R:L132	R:R:V136	2.98	No	No	0	4	4
206	R:R:L186	R:R:V139	2.98	No	No	0	3	5
207	R:R:L187	R:R:V183	2.98	No	No	0	2	3
208	R:R:L225	R:R:V221	2.98	No	No	0	5	2
209	R:R:N315	R:R:V279	2.96	Yes	No	0	9	7
210	R:R:L114	R:R:T118	2.95	No	No	0	6	4
211	R:R:L120	R:R:T116	2.95	No	No	0	4	4
212	R:R:F195	R:R:P213	2.89	No	Yes	0	5	4
213	R:R:K268	R:R:M272	2.88	No	No	0	7	8
214	R:R:Q217	R:R:V221	2.87	No	No	0	1	2
215	R:R:Q299	R:R:V293	2.87	No	No	0	1	5
216	R:R:I80	R:R:L84	2.85	No	No	0	7	4
217	R:R:I102	R:R:L98	2.85	No	No	0	7	5
218	R:R:I321	R:R:L326	2.85	No	No	0	7	6
219	R:R:G312	R:R:W284	2.81	No	Yes	0	7	8
220	R:R:R131	R:R:V193	2.62	No	No	0	6	4
221	R:R:F125	R:R:T116	2.59	No	No	0	7	4
222	R:R:V115	R:R:Y65	2.52	No	Yes	0	6	6
223	R:R:F330	R:R:I97	2.51	Yes	No	0	8	8
224	R:R:F232	R:R:L233	2.44	Yes	No	0	8	4
225	R:R:F330	R:R:N329	2.42	Yes	No	0	8	7
226	R:R:C74	R:R:G75	1.96	No	No	0	4	8
227	R:R:G54	R:R:S57	1.86	No	No	0	3	3
228	R:R:G72	R:R:V71	1.84	No	No	0	8	5
229	R:R:G237	R:R:V236	1.84	No	No	0	3	6
230	R:R:P320	R:R:V79	1.77	No	No	0	9	9
231	R:R:G56	R:R:I59	1.76	No	No	0	1	5
232	R:R:C317	R:R:V68	1.71	No	No	0	7	7
233	R:R:C147	R:R:V181	1.71	No	No	0	8	7
234	R:R:C242	R:R:V153	1.71	No	No	0	7	6
235	R:R:C240	R:R:V236	1.71	No	No	0	4	6
236	R:R:A165	R:R:V157	1.7	No	No	0	6	5
237	R:R:A158	R:R:V159	1.7	No	No	0	8	8
238	R:R:A238	R:R:T149	1.68	No	No	0	6	7
239	R:R:D203	R:R:G204	1.68	No	No	0	4	7
240	R:R:E53	R:R:G54	1.64	No	No	0	2	3
241	R:R:G54	R:R:Q55	1.64	No	No	0	3	4
242	R:R:G56	R:R:Q55	1.64	No	No	0	1	4
243	R:R:L190	R:R:P191	1.64	No	No	0	3	6
244	R:R:S66	R:R:V115	1.62	No	No	0	5	6
245	R:R:A101	R:R:I80	1.62	No	No	0	9	7
246	R:R:S305	R:R:V304	1.62	Yes	No	0	4	4
247	R:R:A318	R:R:I321	1.62	No	No	0	5	7
248	R:R:V67	R:R:V71	1.6	No	No	0	5	5
249	R:R:V153	R:R:V157	1.6	No	No	0	6	5
250	R:R:V173	R:R:V177	1.6	No	No	0	5	5
251	R:R:V221	R:R:V295	1.6	No	No	0	2	4
252	R:R:V289	R:R:V293	1.6	No	No	0	6	5
253	R:R:T198	R:R:V206	1.59	No	No	0	5	4
254	R:R:A199	R:R:L211	1.58	No	No	0	3	4
255	R:R:I189	R:R:S135	1.55	Yes	No	0	7	6
256	R:R:A302	R:R:D301	1.54	No	No	0	4	4
257	R:R:H161	R:R:P162	1.53	No	No	0	7	7
258	R:R:I97	R:R:T93	1.52	No	No	0	8	8
259	R:R:K249	R:R:V160	1.52	No	Yes	0	6	7
260	R:R:M285	R:R:V289	1.52	Yes	No	0	5	6
261	R:R:K90	R:R:T91	1.5	No	No	0	7	7
262	R:R:L190	R:R:V193	1.49	No	No	0	3	4
263	R:R:L241	R:R:V244	1.49	No	No	0	4	4
264	R:R:L307	R:R:V304	1.49	No	No	0	4	4
265	R:R:N140	R:R:V136	1.48	No	No	0	7	4
266	R:R:I247	R:R:I269	1.47	No	No	0	5	7
267	R:R:L271	R:R:T270	1.47	No	No	0	6	7
268	R:R:I95	R:R:M89	1.46	No	No	0	5	6
269	R:R:I247	R:R:M250	1.46	No	No	0	5	8
270	R:R:D301	R:R:V304	1.46	No	No	0	4	4
271	R:R:P171	R:R:R170	1.44	No	No	0	3	6
272	R:R:P215	R:R:R218	1.44	Yes	No	0	2	1
273	R:R:M274	R:R:M275	1.44	No	No	0	5	6
274	R:R:L322	R:R:M275	1.41	No	No	0	8	6
275	R:R:A92	R:R:R169	1.38	No	No	0	5	6
276	R:R:L187	R:R:L190	1.38	No	No	0	2	3
277	R:R:L225	R:R:L292	1.38	No	No	0	5	5
278	R:R:E266	R:R:K263	1.35	No	No	0	6	2
279	R:R:R197	R:R:V194	1.31	No	No	0	4	5
280	R:R:F296	R:R:L292	1.22	No	No	0	4	5
281	R:R:L271	R:R:R267	1.21	No	No	0	6	4
282	R:R:Q260	R:R:R262	1.17	No	No	0	1	3
283	R:R:Q335	R:R:R332	1.17	No	No	0	4	5
284	R:R:H122	R:R:R121	1.13	No	No	0	5	4
285	R:R:R85	R:R:Y86	1.03	No	No	0	4	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.355	6	1	0
2	L:L:?2	11.1817	6	1	0
3	L:L:K3	13.305	4	1	0
4	L:L:?4	8.08556	9	1	0
5	L:L:?6	11.5675	4	1	0
6	R:R:Y65	6.425	4	0	6
7	R:R:Y96	5.67333	6	6	7
8	R:R:N99	8.05	4	7	9
9	R:R:D104	5.41	5	4	9
10	R:R:E105	6.365	4	0	7
11	R:R:M108	3.5025	4	1	6
12	R:R:V111	4.2975	4	1	7
13	R:R:W123	8.41	5	8	8
14	R:R:D137	7.2375	4	1	6
15	R:R:T143	7.685	4	7	6
16	R:R:R155	7.4075	4	2	9
17	R:R:Y156	8.2225	4	11	8
18	R:R:V160	4.3925	4	11	7
19	R:R:I189	3.6275	4	0	7
20	R:R:P213	4.305	4	12	4
21	R:R:P215	4.485	4	12	2
22	R:R:F232	3.9525	4	0	8
23	R:R:P235	3.5575	4	0	9
24	R:R:Y243	7.21	4	2	9
25	R:R:Y276	8.408	5	2	8
26	R:R:W284	9.79	4	10	8
27	R:R:M285	3.9125	4	0	5
28	R:R:S305	3.65	4	3	4
29	R:R:Y313	6.964	5	1	7
30	R:R:N315	7.4575	4	10	9
31	R:R:Y323	9.26	4	2	9
32	R:R:F330	3.79	6	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	31.7743	16.88	Yes	Yes	1	0	0
2	L:L:?2	L:L:K3	23.6321	27.98	Yes	Yes	1	0	0
3	L:L:?4	R:R:L114	11.6907	18.17	Yes	No	0	0	6
4	L:L:?4	R:R:S117	15.5365	8.62	Yes	No	0	0	6
5	L:L:?1	L:L:?6	11.974	25.42	Yes	Yes	1	0	0
6	L:L:?6	L:L:F5	23.4974	11.07	Yes	No	0	0	0
7	L:L:F5	R:R:S305	15.1463	5.28	No	Yes	0	0	4
8	L:L:K3	R:R:Y313	27.9424	9.55	Yes	Yes	1	0	7
9	R:R:L107	R:R:Y313	18.1793	11.72	No	Yes	0	7	7
10	R:R:L107	R:R:M108	10.7942	4.24	No	Yes	0	7	6
11	R:R:G72	R:R:M108	12.2387	3.49	No	Yes	1	8	6
12	R:R:V111	R:R:Y313	15.1602	3.79	Yes	Yes	1	7	7
13	R:R:M108	R:R:V111	10.7292	3.04	Yes	Yes	1	6	7
14	L:L:?2	R:R:M141	99.3172	3.37	Yes	No	0	0	7
15	R:R:I145	R:R:M141	96.0985	4.37	No	No	0	7	7
16	R:R:I145	R:R:P235	100	3.39	No	Yes	0	7	9
17	R:R:P235	R:R:T149	99.6052	3.5	Yes	No	0	9	7
18	R:R:I239	R:R:T149	99.3823	3.04	No	No	0	8	7
19	R:R:I239	R:R:S152	99.2569	10.84	No	No	0	8	9
20	R:R:S152	R:R:Y243	99.1222	5.09	No	Yes	0	9	9
21	R:R:R155	R:R:Y243	62.3734	6.17	Yes	Yes	2	9	9
22	R:R:R155	R:R:Y323	20.9104	5.14	Yes	Yes	2	9	9
23	R:R:L148	R:R:Y323	35.0255	9.38	No	Yes	2	8	9
24	R:R:L100	R:R:L148	33.2373	5.54	No	No	0	9	8
25	R:R:D104	R:R:L100	31.3562	6.79	Yes	No	0	9	9
26	R:R:Y243	R:R:Y276	36.4143	4.96	Yes	Yes	2	9	8
27	R:R:Y276	R:R:Y323	17.8309	17.87	Yes	Yes	2	8	9
28	R:R:D104	R:R:P320	15.7873	3.22	Yes	No	4	9	9
29	R:R:P320	R:R:V79	14.0084	1.77	No	No	0	9	9
30	R:R:M272	R:R:Y276	27.7055	7.18	No	Yes	0	8	8
31	R:R:L326	R:R:M272	24.51	4.24	No	No	0	6	8
32	R:R:I321	R:R:L326	23.5067	2.85	No	No	0	7	6
33	R:R:F325	R:R:I321	21.3144	7.54	No	No	0	6	7
34	R:R:F325	R:R:F334	20.2044	5.36	No	No	0	6	5
35	R:R:F330	R:R:F334	13.2791	4.29	Yes	No	0	8	5
36	R:R:L151	R:R:R155	60.3251	12.15	No	Yes	0	9	9
37	R:R:L151	R:R:Y96	59.6145	5.86	No	Yes	0	9	7
38	R:R:D154	R:R:Y96	26.7859	5.75	No	Yes	0	8	7
39	R:R:N178	R:R:Y96	29.9443	5.81	No	Yes	0	8	7
40	R:R:N178	R:R:N99	28.9085	10.9	No	Yes	0	8	9
41	R:R:N99	R:R:T143	24.575	4.39	Yes	Yes	7	9	6
42	R:R:S117	R:R:W123	14.2824	6.18	No	Yes	0	6	8
43	R:R:A207	R:R:N209	17.4222	3.13	No	No	0	5	5
44	R:R:A207	R:R:N201	15.2764	4.69	No	No	0	5	3
45	R:R:S185	R:R:T143	22.4988	4.8	No	Yes	0	8	6
46	R:R:S185	R:R:Y146	21.3981	6.36	No	No	0	8	5
47	R:R:F142	R:R:Y146	20.288	4.13	No	No	0	6	5
48	R:R:F142	R:R:I189	18.0399	5.02	No	Yes	0	6	7
49	R:R:I189	R:R:S135	13.4324	1.55	Yes	No	0	7	6
50	R:R:S135	R:R:V193	12.2573	6.46	No	No	0	6	4
51	R:R:D154	R:R:R169	25.7222	9.53	No	No	0	8	6
52	R:R:A158	R:R:R169	23.5671	5.53	No	No	0	8	6
53	R:R:A158	R:R:V159	22.4756	1.7	No	No	0	8	8
54	R:R:I246	R:R:V159	21.3702	3.07	No	No	0	9	8
55	R:R:I246	R:R:V160	20.2787	3.07	No	Yes	0	9	7
56	R:R:V160	R:R:Y156	13.3302	8.83	Yes	Yes	11	7	8
57	L:L:?1	R:R:L220	21.1751	3.36	Yes	No	0	0	5
58	R:R:L220	R:R:M212	10.1393	7.07	No	No	0	5	4
59	R:R:L220	R:R:V295	10.1393	5.96	No	No	0	5	4
60	L:L:?2	R:R:Q291	22.8983	7.4	Yes	No	0	0	6
61	R:R:F287	R:R:Q291	21.7882	15.23	No	No	0	6	6
62	R:R:F287	R:R:Y288	19.3637	4.13	No	No	0	6	7
63	R:R:F228	R:R:Y288	18.1375	13.41	No	No	0	5	7
64	R:R:F228	R:R:F232	16.902	3.22	No	Yes	0	5	8
65	L:L:?2	L:L:?4	42.9772	3.61	Yes	Yes	1	0	0
66	L:L:?4	L:L:?6	15.6247	5.16	Yes	Yes	1	0	0
67	L:L:?4	R:R:N209	11.0033	4.51	Yes	No	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:N209	6.66	1	Yes	No	0	5	0	1
L:L:?1	R:R:M210	5.71	1	Yes	No	0	4	0	1
L:L:?1	R:R:L220	3.36	1	Yes	No	0	5	0	1
L:L:?2	R:R:M141	3.37	1	Yes	No	0	7	0	1
L:L:?2	R:R:M210	7.85	1	Yes	No	0	4	0	1
L:L:?2	R:R:Q291	7.4	1	Yes	No	0	6	0	1
L:L:K3	R:R:D137	11.06	1	Yes	Yes	0	6	0	1
L:L:K3	R:R:Y313	9.55	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:L114	18.17	1	Yes	No	0	6	0	1
L:L:?4	R:R:S117	8.62	1	Yes	No	0	6	0	1
L:L:?4	R:R:L134	7.95	1	Yes	No	0	5	0	1
L:L:?4	R:R:D137	10.02	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:N209	4.51	1	Yes	No	0	5	0	1
L:L:F5	R:R:S305	5.28	0	No	Yes	0	4	0	1
L:L:F5	R:R:Q306	5.86	0	No	No	0	4	0	1
L:L:?6	R:R:D300	4.62	1	Yes	No	0	4	0	1
R:R:I61	R:R:Q306	5.49	0	No	No	5	4	2	1
R:R:L114	R:R:Y65	3.52	0	No	Yes	6	6	1	2
R:R:V309	R:R:Y65	7.57	0	No	Yes	5	6	2	2
R:R:L107	R:R:Y313	11.72	0	No	Yes	7	7	2	1
R:R:D137	R:R:S110	4.42	1	Yes	No	6	6	1	2
R:R:V111	R:R:Y313	3.79	1	Yes	Yes	7	7	2	1
R:R:S117	R:R:W123	6.18	0	No	Yes	6	8	1	2
R:R:L134	R:R:S196	7.51	0	No	No	5	5	1	2
R:R:C208	R:R:L134	3.17	0	No	No	9	5	2	1
R:R:D137	R:R:Y313	3.45	1	Yes	Yes	6	7	1	1
R:R:I145	R:R:M141	4.37	0	No	No	7	7	2	1
R:R:M141	R:R:W284	8.14	0	No	Yes	7	8	1	2
R:R:A207	R:R:N209	3.13	0	No	No	5	5	2	1
R:R:F223	R:R:M210	6.22	0	No	No	6	4	2	1
R:R:L220	R:R:M212	7.07	0	No	No	5	4	1	2
R:R:L220	R:R:V295	5.96	0	No	No	5	4	1	2
R:R:F287	R:R:Q291	15.23	0	No	No	6	6	2	1
R:R:N294	R:R:V290	4.43	3	No	No	4	4	2	2
R:R:S305	R:R:V290	3.23	3	Yes	No	4	4	1	2
R:R:N294	R:R:S305	4.47	3	No	Yes	4	4	2	1
R:R:Q306	R:R:T303	4.25	0	No	No	4	2	1	2
R:R:V309	R:R:Y313	6.31	0	No	Yes	5	7	2	1
R:R:L114	R:R:T118	2.95	0	No	No	6	4	1	2
R:R:S305	R:R:V304	1.62	3	Yes	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XIP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	265
Number of Links	285
Number of Hubs	32
Number of Links mediated by Hubs	122
Number of Communities	12
Number of Nodes involved in Communities	51
Number of Links involved in Communities	61

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	39603
Length Of Smallest Path	3
Average Path Length	15.3131
Length of Longest Path	33
Minimum Path Strength	1.3
Average Path Strength	6.24275
Maximum Path Strength	22.43
Minimum Path Correlation	0.7
Average Path Correlation	0.926745
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	49.5478
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.6892
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • cellular response to lipid • response to estradiol • cellular response to estradiol stimulus • cell surface receptor signaling pathway • glutamate receptor signaling pathway • cerebellum development • metencephalon development • hindbrain development • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • cell projection • neuron projection • plasma membrane bounded cell projection • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • response to ketone • response to prostaglandin • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	004
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	6931074
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(2R)-2-amino-3-(1H-indol-3-yl)propanoic acid DTR D-Tryptophan (R)-tryptophan
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	TY5
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	TY5
Name	O-benzyl-L-tyrosine
Synonyms
Identifier
Formula	C16 H17 N O3
Molecular Weight	271.311
SMILES
PubChem	725701
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	38
Total Aromatic Bonds	12


Code	A1D
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30872
Sequence	>8XIP_nogp_Chain_R S E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y A K M K T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L R H W P F G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H P I K A A R Y R R P T V A K V V N L G V W V L S L L V I L P I V V F S R T A A N S D G T V A C N M L M P E P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G W Q Q R K R S E R K I T L M V M M V M V F V I C W M P F Y V V Q L V N V F A E Q D D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F K R S F Q R Y Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIP	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-		3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-		2.65	2024-07-03	doi.org/10.1073/pnas.2400298121

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