psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:K2	26.86	Yes	Yes	1	0	0
2	L:L:?1	L:L:?6	16.88	Yes	Yes	1	0	0
3	L:L:?1	R:R:M141	5.61	Yes	No	1	0	7
4	L:L:?1	R:R:F142	3.87	Yes	Yes	1	0	6
5	L:L:?1	R:R:F223	3.87	Yes	No	0	0	6
6	L:L:?1	R:R:T227	5.85	Yes	No	1	0	5
7	L:L:?1	R:R:F287	7.73	Yes	No	1	0	6
8	L:L:?1	R:R:Q291	17.96	Yes	No	1	0	6
9	L:L:?3	L:L:K2	19.67	Yes	Yes	1	0	0
10	L:L:K2	R:R:L114	4.23	Yes	Yes	1	0	6
11	L:L:K2	R:R:F287	4.96	Yes	No	1	0	6
12	L:L:?3	L:L:?4	16.98	Yes	Yes	1	0	0
13	L:L:?3	R:R:L114	28.39	Yes	Yes	1	0	6
14	L:L:?3	R:R:S117	8.62	Yes	No	0	0	6
15	L:L:?3	R:R:L134	4.54	Yes	No	0	0	5
16	L:L:?3	R:R:D137	13.36	Yes	No	1	0	6
17	L:L:?3	R:R:N209	3.38	Yes	No	0	0	5
18	L:L:?3	R:R:Y313	3.85	Yes	Yes	1	0	7
19	L:L:?4	L:L:?5	51.09	Yes	No	1	0	0
20	L:L:?4	L:L:?6	10.57	Yes	Yes	1	0	0
21	L:L:?4	R:R:A302	7.44	Yes	No	0	0	4
22	L:L:?4	R:R:S305	10.63	Yes	No	0	0	4
23	L:L:?5	L:L:?6	21.55	No	Yes	1	0	0
24	L:L:?5	R:R:E298	25.53	No	No	0	0	1
25	L:L:?6	R:R:L220	15.67	Yes	No	0	0	5
26	L:L:?6	R:R:V224	12.04	Yes	No	0	0	5
27	L:L:?6	R:R:V295	9.63	Yes	No	0	0	4
28	R:R:I61	R:R:Y65	4.84	No	Yes	0	5	6
29	R:R:S62	R:R:V115	4.85	No	No	0	6	6
30	R:R:F63	R:R:S66	3.96	No	No	0	4	5
31	R:R:V111	R:R:Y65	5.05	Yes	Yes	0	7	6
32	R:R:V115	R:R:Y65	17.66	No	Yes	0	6	6
33	R:R:I310	R:R:Y65	7.25	No	Yes	0	4	6
34	R:R:C69	R:R:V111	6.83	No	Yes	0	5	7
35	R:R:G72	R:R:M108	3.49	No	No	1	8	6
36	R:R:C317	R:R:G72	3.92	No	No	1	7	8
37	R:R:E105	R:R:L73	13.25	No	No	0	7	6
38	R:R:D104	R:R:N76	20.2	No	No	0	9	9
39	R:R:N76	R:R:P320	11.4	No	No	0	9	9
40	R:R:F325	R:R:M78	4.98	No	No	0	6	6
41	R:R:F334	R:R:M78	3.73	No	No	0	5	6
42	R:R:A101	R:R:V79	3.39	No	No	0	9	9
43	R:R:P320	R:R:V79	3.53	No	No	0	9	9
44	R:R:F330	R:R:V79	6.55	Yes	No	0	8	9
45	R:R:I80	R:R:L84	5.71	Yes	No	0	7	4
46	R:R:I80	R:R:L98	4.28	Yes	No	3	7	5
47	R:R:A101	R:R:I80	3.25	No	Yes	0	9	7
48	R:R:I102	R:R:I80	5.89	No	Yes	3	7	7
49	R:R:Y81	R:R:Y86	3.97	No	No	0	3	5
50	R:R:F330	R:R:V82	13.11	Yes	No	0	8	7
51	R:R:S333	R:R:V82	3.23	Yes	No	0	5	7
52	R:R:I337	R:R:Y86	6.04	No	No	0	6	5
53	R:R:A92	R:R:Y96	5.34	No	Yes	0	5	7
54	R:R:N329	R:R:N94	6.81	No	No	0	7	8
55	R:R:A174	R:R:I95	6.5	No	Yes	0	7	5
56	R:R:I95	R:R:K175	4.36	Yes	No	0	5	3
57	R:R:I95	R:R:N178	4.25	Yes	No	0	5	8
58	R:R:V150	R:R:Y96	8.83	No	Yes	0	6	7
59	R:R:L151	R:R:Y96	7.03	No	Yes	0	9	7
60	R:R:D154	R:R:Y96	10.34	No	Yes	0	8	7
61	R:R:A174	R:R:Y96	6.67	No	Yes	0	7	7
62	R:R:N178	R:R:Y96	3.49	No	Yes	0	8	7
63	R:R:I102	R:R:L98	4.28	No	No	3	7	5
64	R:R:C147	R:R:N99	4.72	No	No	0	8	9
65	R:R:N178	R:R:N99	17.71	No	No	0	8	9
66	R:R:N99	R:R:W182	12.43	No	No	0	9	9
67	R:R:L100	R:R:L148	4.15	No	Yes	1	9	8
68	R:R:L100	R:R:N319	5.49	No	Yes	1	9	9
69	R:R:L100	R:R:Y323	4.69	No	Yes	1	9	9
70	R:R:A103	R:R:T143	3.36	No	Yes	0	8	6
71	R:R:A103	R:R:S144	3.42	No	No	0	8	9
72	R:R:D104	R:R:S316	11.78	No	No	0	9	8
73	R:R:D104	R:R:N319	4.04	No	Yes	0	9	9
74	R:R:L106	R:R:N140	12.36	No	No	0	7	7
75	R:R:L107	R:R:N140	6.87	No	No	0	7	7
76	R:R:L107	R:R:Y313	3.52	No	Yes	0	7	7
77	R:R:L107	R:R:S316	4.5	No	No	0	7	8
78	R:R:M108	R:R:Y313	3.59	No	Yes	1	6	7
79	R:R:C317	R:R:M108	3.24	No	No	1	7	6
80	R:R:F113	R:R:S110	3.96	No	Yes	1	5	6
81	R:R:S110	R:R:V133	3.23	Yes	No	1	6	5
82	R:R:D137	R:R:S110	8.83	No	Yes	1	6	6
83	R:R:P112	R:R:V111	3.53	No	Yes	0	8	7
84	R:R:V111	R:R:Y313	3.79	Yes	Yes	0	7	7
85	R:R:F113	R:R:F125	6.43	No	No	0	5	7
86	R:R:F113	R:R:V133	11.8	No	No	1	5	5
87	R:R:H122	R:R:L120	14.14	No	No	4	5	4
88	R:R:L120	R:R:P124	3.28	No	No	4	4	3
89	R:R:H122	R:R:P124	7.63	No	No	4	5	3
90	R:R:F125	R:R:W123	7.02	No	Yes	0	7	8
91	R:R:L129	R:R:W123	3.42	No	Yes	0	5	8
92	R:R:C130	R:R:W123	7.84	No	Yes	1	9	8
93	R:R:V133	R:R:W123	6.13	No	Yes	1	5	8
94	R:R:T198	R:R:W123	3.64	No	Yes	1	5	8
95	R:R:C208	R:R:W123	3.92	No	Yes	1	9	8
96	R:R:F125	R:R:P124	7.22	No	No	0	7	3
97	R:R:C130	R:R:T198	3.38	No	No	1	9	5
98	R:R:C130	R:R:C208	7.28	No	No	1	9	9
99	R:R:R131	R:R:S196	3.95	No	No	0	6	5
100	R:R:R131	R:R:R197	6.4	No	No	0	6	4
101	R:R:I192	R:R:L134	4.28	No	No	0	5	5
102	R:R:I189	R:R:S135	4.64	Yes	No	0	7	6
103	R:R:S135	R:R:V193	4.85	No	No	0	6	4
104	R:R:N140	R:R:V136	5.91	No	No	0	7	4
105	R:R:D137	R:R:Y313	4.6	No	Yes	1	6	7
106	R:R:A138	R:R:I189	3.25	No	Yes	0	4	7
107	R:R:S185	R:R:V139	4.85	No	No	0	8	5
108	R:R:I189	R:R:V139	4.61	Yes	No	0	7	5
109	R:R:F142	R:R:M141	6.22	Yes	No	1	6	7
110	R:R:M141	R:R:W284	9.31	No	Yes	1	7	8
111	R:R:F142	R:R:S185	5.28	Yes	No	0	6	8
112	R:R:F142	R:R:V188	6.55	Yes	No	0	6	5
113	R:R:F142	R:R:I189	5.02	Yes	Yes	0	6	7
114	R:R:F142	R:R:T227	9.08	Yes	No	1	6	5
115	R:R:T143	R:R:V181	4.76	Yes	No	0	6	7
116	R:R:T143	R:R:W182	18.19	Yes	No	0	6	9
117	R:R:I145	R:R:P235	3.39	No	Yes	0	7	9
118	R:R:F280	R:R:I145	3.77	Yes	No	1	9	7
119	R:R:I145	R:R:W284	5.87	No	Yes	1	7	8
120	R:R:V181	R:R:Y146	6.31	No	No	0	7	5
121	R:R:L184	R:R:Y146	8.21	No	No	0	4	5
122	R:R:M230	R:R:Y146	5.99	No	No	0	4	5
123	R:R:F280	R:R:L148	4.87	Yes	Yes	1	9	8
124	R:R:L148	R:R:N319	4.12	Yes	Yes	1	8	9
125	R:R:L148	R:R:Y323	7.03	Yes	Yes	1	8	9
126	R:R:P235	R:R:T149	3.5	Yes	No	0	9	7
127	R:R:I239	R:R:T149	6.08	No	No	0	8	7
128	R:R:V150	R:R:V177	4.81	No	No	0	6	5
129	R:R:I239	R:R:S152	9.29	No	No	0	8	9
130	R:R:C242	R:R:S152	5.16	No	No	0	7	9
131	R:R:S152	R:R:Y243	5.09	No	Yes	0	9	9
132	R:R:D154	R:R:R169	13.1	No	No	0	8	6
133	R:R:R155	R:R:Y243	8.23	No	Yes	0	9	9
134	R:R:R155	R:R:Y323	7.2	No	Yes	0	9	9
135	R:R:V160	R:R:Y156	8.83	Yes	Yes	5	7	8
136	R:R:H161	R:R:Y156	6.53	Yes	Yes	5	7	8
137	R:R:C242	R:R:Y156	4.03	No	Yes	0	7	8
138	R:R:L245	R:R:Y156	9.38	No	Yes	0	4	8
139	R:R:A165	R:R:V157	3.39	No	No	0	6	5
140	R:R:A158	R:R:R169	5.53	No	No	0	8	6
141	R:R:I246	R:R:V159	6.14	No	No	0	9	8
142	R:R:H161	R:R:V160	5.54	Yes	Yes	5	7	7
143	R:R:K249	R:R:V160	4.55	No	Yes	0	6	7
144	R:R:R167	R:R:Y168	12.35	No	No	0	4	4
145	R:R:V188	R:R:Y226	7.57	No	No	0	5	3
146	R:R:F223	R:R:I192	5.02	No	No	0	6	5
147	R:R:F195	R:R:V194	10.49	Yes	No	0	5	5
148	R:R:F195	R:R:M212	21.15	Yes	Yes	2	5	4
149	R:R:F195	R:R:P213	5.78	Yes	No	2	5	4
150	R:R:M210	R:R:M212	13	No	Yes	0	4	4
151	R:R:M212	R:R:P213	3.35	Yes	No	2	4	4
152	R:R:M212	R:R:W219	12.8	Yes	No	2	4	2
153	R:R:P213	R:R:W219	8.11	No	No	2	4	2
154	R:R:P215	R:R:R218	4.32	No	No	0	2	1
155	R:R:L220	R:R:Q217	3.99	No	No	0	5	1
156	R:R:V221	R:R:V295	4.81	No	No	0	2	4
157	R:R:Q291	R:R:V224	4.3	No	No	0	6	5
158	R:R:T227	R:R:Y288	4.99	No	Yes	1	5	7
159	R:R:F228	R:R:L233	9.74	No	No	0	5	4
160	R:R:F228	R:R:Y288	5.16	No	Yes	0	5	7
161	R:R:F228	R:R:L292	7.31	No	No	0	5	5
162	R:R:G231	R:R:P235	4.06	No	Yes	0	5	9
163	R:R:F232	R:R:V236	5.24	Yes	No	0	8	6
164	R:R:F232	R:R:W284	5.01	Yes	Yes	1	8	8
165	R:R:F232	R:R:Y288	8.25	Yes	Yes	1	8	7
166	R:R:L234	R:R:P235	3.28	No	Yes	0	4	9
167	R:R:F280	R:R:V236	5.24	Yes	No	0	9	6
168	R:R:F280	R:R:I239	3.77	Yes	No	0	9	8
169	R:R:L241	R:R:L245	5.54	No	No	0	4	4
170	R:R:V273	R:R:Y243	5.05	No	Yes	0	7	9
171	R:R:I247	R:R:R251	6.26	No	No	0	5	5
172	R:R:I247	R:R:T270	4.56	No	No	0	5	7
173	R:R:I247	R:R:V273	6.14	No	No	0	5	7
174	R:R:K249	R:R:V253	4.55	No	No	0	6	6
175	R:R:E266	R:R:R251	9.3	No	No	0	6	5
176	R:R:M252	R:R:V253	6.09	No	No	0	5	6
177	R:R:A254	R:R:Q260	4.55	No	No	0	4	1
178	R:R:A257	R:R:W259	5.19	No	No	0	4	3
179	R:R:Q260	R:R:W259	16.43	No	No	0	1	3
180	R:R:E266	R:R:K263	14.85	No	No	0	6	2
181	R:R:M272	R:R:M275	5.78	No	No	1	8	6
182	R:R:L322	R:R:M275	5.65	Yes	No	1	8	6
183	R:R:L322	R:R:V276	4.47	Yes	No	1	8	8
184	R:R:V276	R:R:Y323	6.31	No	Yes	1	8	9
185	R:R:F280	R:R:W284	5.01	Yes	Yes	1	9	8
186	R:R:W284	R:R:Y288	8.68	Yes	Yes	1	8	7
187	R:R:G312	R:R:W284	4.22	No	Yes	0	7	8
188	R:R:N315	R:R:W284	7.91	No	Yes	0	9	8
189	R:R:M285	R:R:P286	3.35	No	No	0	5	9
190	R:R:L311	R:R:P286	3.28	No	No	0	7	9
191	R:R:F287	R:R:Q291	12.88	No	No	1	6	6
192	R:R:N294	R:R:V290	4.43	No	No	0	4	4
193	R:R:S308	R:R:V290	4.85	No	No	0	6	4
194	R:R:E298	R:R:N294	11.83	No	No	0	1	4
195	R:R:F296	R:R:V295	6.55	No	No	0	4	4
196	R:R:Q306	R:R:T303	11.34	No	No	0	4	2
197	R:R:N315	R:R:N319	5.45	No	Yes	0	9	9
198	R:R:N319	R:R:Y323	5.81	Yes	Yes	1	9	9
199	R:R:L322	R:R:Y323	4.69	Yes	Yes	1	8	9
200	R:R:F330	R:R:G324	6.02	Yes	No	0	8	7
201	R:R:F325	R:R:F330	12.86	No	Yes	0	6	8
202	R:R:N329	R:R:S327	5.96	No	No	0	7	8
203	R:R:D328	R:R:N329	4.04	No	No	0	5	7
204	R:R:R332	R:R:S333	6.59	No	Yes	0	5	5
205	R:R:V159	R:R:V160	3.21	No	Yes	0	8	7
206	R:R:S185	R:R:T143	3.2	No	Yes	0	8	6
207	R:R:R332	R:R:R336	3.2	No	No	0	5	4
208	R:R:A58	R:R:L119	3.15	No	No	0	4	4
209	R:R:C283	R:R:N315	3.15	No	No	0	9	9
210	R:R:I83	R:R:V82	3.07	No	No	0	7	7
211	R:R:I97	R:R:T93	3.04	No	No	0	8	8
212	R:R:A254	R:R:E266	3.02	No	No	0	4	6
213	R:R:L73	R:R:S77	3	No	No	0	6	4
214	R:R:L109	R:R:S110	3	No	Yes	0	5	6
215	R:R:L134	R:R:S196	3	No	No	0	5	5
216	R:R:L114	R:R:V309	2.98	Yes	No	0	6	5
217	R:R:L186	R:R:V139	2.98	No	No	0	3	5
218	R:R:L114	R:R:T118	2.95	Yes	No	0	6	4
219	R:R:L120	R:R:T116	2.95	No	No	0	4	4
220	R:R:I83	R:R:I97	2.94	No	No	0	7	8
221	R:R:N94	R:R:T91	2.92	No	No	0	8	7
222	R:R:I282	R:R:M278	2.92	No	No	0	5	5
223	R:R:I269	R:R:K268	2.91	No	No	0	7	7
224	R:R:P171	R:R:R170	2.88	No	No	0	3	6
225	R:R:I310	R:R:L307	2.85	No	No	0	4	4
226	R:R:I321	R:R:L322	2.85	No	Yes	0	7	8
227	R:R:L229	R:R:M230	2.83	No	No	0	4	4
228	R:R:K256	R:R:L255	2.82	No	No	0	3	4
229	R:R:G126	R:R:W123	2.81	No	Yes	0	7	8
230	R:R:M89	R:R:N94	2.8	No	No	0	6	8
231	R:R:A127	R:R:R131	2.77	No	No	0	2	6
232	R:R:H161	R:R:V157	2.77	Yes	No	0	7	5
233	R:R:A165	R:R:R169	2.77	No	No	0	6	6
234	R:R:L225	R:R:L292	2.77	No	No	0	5	5
235	R:R:P215	R:R:W219	2.7	No	No	0	2	2
236	R:R:E105	R:R:N76	2.63	No	No	0	7	9
237	R:R:H161	R:R:K164	2.62	Yes	No	0	7	4
238	R:R:F232	R:R:V281	2.62	Yes	No	0	8	5
239	R:R:S333	R:R:Y86	2.54	Yes	No	0	5	5
240	R:R:V277	R:R:Y243	2.52	No	Yes	0	7	9
241	R:R:Q260	R:R:R264	2.34	No	No	0	1	4
242	R:R:Q306	R:R:Y65	2.25	No	Yes	0	4	6
243	R:R:F195	R:R:R197	2.14	Yes	No	0	5	4
244	R:R:R167	R:R:R170	2.13	No	No	0	4	6
245	R:R:G75	R:R:P320	2.03	No	No	0	8	9
246	R:R:C74	R:R:G75	1.96	No	No	0	4	8
247	R:R:G72	R:R:V71	1.84	No	No	0	8	5
248	R:R:G180	R:R:V183	1.84	No	No	0	4	3
249	R:R:A199	R:R:A207	1.79	No	No	0	3	5
250	R:R:P286	R:R:S308	1.78	No	No	0	9	6
251	R:R:C317	R:R:V68	1.71	No	No	0	7	7
252	R:R:A87	R:R:S333	1.71	No	Yes	0	6	5
253	R:R:C242	R:R:V153	1.71	No	No	0	7	6
254	R:R:G180	R:R:L179	1.71	No	No	0	4	4
255	R:R:C240	R:R:V236	1.71	No	No	0	4	6
256	R:R:C240	R:R:V277	1.71	No	No	0	4	7
257	R:R:C283	R:R:V279	1.71	No	No	0	9	7
258	R:R:I95	R:R:P171	1.69	Yes	No	0	5	3
259	R:R:I163	R:R:P162	1.69	No	No	0	6	7
260	R:R:A238	R:R:T149	1.68	No	No	0	6	7
261	R:R:M212	R:R:P191	1.68	Yes	No	0	4	6
262	R:R:L190	R:R:P191	1.64	No	No	0	3	6
263	R:R:S66	R:R:V67	1.62	No	No	0	5	5
264	R:R:S308	R:R:V304	1.62	No	No	0	6	4
265	R:R:A248	R:R:M252	1.61	No	No	0	3	5
266	R:R:V67	R:R:V71	1.6	No	No	0	5	5
267	R:R:V173	R:R:V177	1.6	No	No	0	5	5
268	R:R:V176	R:R:V177	1.6	No	No	0	3	5
269	R:R:V289	R:R:V293	1.6	No	No	0	6	5
270	R:R:C69	R:R:L70	1.59	No	No	0	5	5
271	R:R:T172	R:R:V173	1.59	No	No	0	3	5
272	R:R:T91	R:R:T93	1.57	No	No	0	7	8
273	R:R:I64	R:R:V68	1.54	No	No	0	5	7
274	R:R:I269	R:R:V273	1.54	No	No	0	7	7
275	R:R:I282	R:R:V281	1.54	No	No	0	5	5
276	R:R:H161	R:R:P162	1.53	Yes	No	0	7	7
277	R:R:L119	R:R:S62	1.5	No	No	0	4	6
278	R:R:K90	R:R:T91	1.5	No	No	0	7	7
279	R:R:L187	R:R:V183	1.49	No	No	0	2	3
280	R:R:D301	R:R:T303	1.45	No	No	0	4	2
281	R:R:K88	R:R:K90	1.44	No	No	0	6	7
282	R:R:M274	R:R:M278	1.44	No	No	0	5	5
283	R:R:I64	R:R:L60	1.43	No	No	0	5	5
284	R:R:L326	R:R:M272	1.41	No	No	1	6	8
285	R:R:L326	R:R:M275	1.41	No	No	1	6	6
286	R:R:L128	R:R:L129	1.38	No	No	0	1	5
287	R:R:R264	R:R:S265	1.32	No	No	0	4	5
288	R:R:N294	R:R:Q299	1.32	No	No	0	4	1
289	R:R:K263	R:R:R267	1.24	No	No	0	2	4
290	R:R:L84	R:R:R85	1.21	No	No	0	4	4
291	R:R:L271	R:R:R267	1.21	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.0787	8	1	0
2	L:L:K2	13.93	4	1	0
3	L:L:?3	12.3488	8	1	0
4	L:L:?4	19.342	5	1	0
5	L:L:?6	14.39	6	1	0
6	R:R:Y65	7.41	5	0	6
7	R:R:I80	4.7825	4	3	7
8	R:R:I95	4.2	4	0	5
9	R:R:Y96	6.95	6	0	7
10	R:R:S110	4.755	4	1	6
11	R:R:V111	4.8	4	0	7
12	R:R:L114	9.6375	4	1	6
13	R:R:W123	4.96857	7	1	8
14	R:R:F142	6.00333	6	1	6
15	R:R:T143	7.3775	4	0	6
16	R:R:L148	5.0425	4	1	8
17	R:R:Y156	7.1925	4	5	8
18	R:R:V160	5.5325	4	5	7
19	R:R:H161	3.798	5	5	7
20	R:R:I189	4.38	4	0	7
21	R:R:F195	9.89	4	2	5
22	R:R:M212	10.396	5	2	4
23	R:R:F232	5.28	4	1	8
24	R:R:P235	3.5575	4	0	9
25	R:R:Y243	5.2225	4	0	9
26	R:R:F280	4.532	5	1	9
27	R:R:W284	6.57286	7	1	8
28	R:R:Y288	6.77	4	1	7
29	R:R:Y313	3.87	5	1	7
30	R:R:N319	4.982	5	1	9
31	R:R:L322	4.415	4	1	8
32	R:R:Y323	5.955	6	1	9
33	R:R:F330	9.635	4	0	8
34	R:R:S333	3.5175	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?6	28.4041	16.88	Yes	Yes	1	0	0
2	L:L:?4	L:L:?6	10.798	10.57	Yes	Yes	1	0	0
3	L:L:?1	L:L:K2	68.848	26.86	Yes	Yes	1	0	0
4	L:L:?3	L:L:K2	66.285	19.67	Yes	Yes	1	0	0
5	L:L:?1	R:R:F223	23.146	3.87	Yes	No	0	0	6
6	R:R:F223	R:R:I192	21.4286	5.02	No	No	0	6	5
7	R:R:I192	R:R:L134	21.1555	4.28	No	No	0	5	5
8	L:L:?5	L:L:?6	13.6428	21.55	No	Yes	1	0	0
9	L:L:?5	R:R:E298	21.5519	25.53	No	No	0	0	1
10	L:L:?3	R:R:Y313	59.9524	3.85	Yes	Yes	1	0	7
11	R:R:V111	R:R:Y313	38.973	3.79	Yes	Yes	0	7	7
12	R:R:V111	R:R:Y65	29.003	5.05	Yes	Yes	0	7	6
13	R:R:V115	R:R:Y65	10.8772	17.66	No	Yes	0	6	6
14	R:R:M108	R:R:Y313	26.6778	3.59	No	Yes	1	6	7
15	R:R:G72	R:R:M108	13.3785	3.49	No	No	1	8	6
16	R:R:G72	R:R:V71	10.8772	1.84	No	No	0	8	5
17	R:R:C317	R:R:M108	10.7011	3.24	No	No	1	7	6
18	L:L:?1	R:R:M141	63.7573	5.61	Yes	No	1	0	7
19	R:R:M141	R:R:W284	100	9.31	No	Yes	1	7	8
20	R:R:N315	R:R:W284	37.3084	7.91	No	Yes	0	9	8
21	R:R:N315	R:R:N319	35.6702	5.45	No	Yes	0	9	9
22	R:R:D104	R:R:N319	86.2515	4.04	No	Yes	0	9	9
23	R:R:D104	R:R:N76	84.6662	20.2	No	No	0	9	9
24	R:R:N76	R:R:P320	76.9509	11.4	No	No	0	9	9
25	R:R:P320	R:R:V79	70.9794	3.53	No	No	0	9	9
26	R:R:F330	R:R:V79	56.4295	6.55	Yes	No	0	8	9
27	R:R:A101	R:R:V79	15.052	3.39	No	No	0	9	9
28	R:R:A101	R:R:I80	12.5859	3.25	No	Yes	0	9	7
29	R:R:F330	R:R:V82	45.5082	13.11	Yes	No	0	8	7
30	R:R:S333	R:R:V82	17.5004	3.23	Yes	No	0	5	7
31	L:L:?1	R:R:F142	44.7067	3.87	Yes	Yes	1	0	6
32	R:R:F142	R:R:S185	68.663	5.28	Yes	No	0	6	8
33	R:R:S185	R:R:T143	63.8894	3.2	No	Yes	0	8	6
34	R:R:T143	R:R:W182	47.9655	18.19	Yes	No	0	6	9
35	R:R:N99	R:R:W182	46.0102	12.43	No	No	0	9	9
36	R:R:N178	R:R:N99	42.1173	17.71	No	No	0	8	9
37	R:R:N178	R:R:Y96	28.2808	3.49	No	Yes	0	8	7
38	R:R:I83	R:R:V82	27.1182	3.07	No	No	0	7	7
39	R:R:I83	R:R:I97	24.7402	2.94	No	No	0	7	8
40	R:R:I97	R:R:T93	22.3445	3.04	No	No	0	8	8
41	R:R:T91	R:R:T93	19.9313	1.57	No	No	0	7	8
42	R:R:N94	R:R:T91	12.5859	2.92	No	No	0	8	7
43	R:R:I95	R:R:N178	17.3507	4.25	Yes	No	0	5	8
44	R:R:V150	R:R:Y96	13.2905	8.83	No	Yes	0	6	7
45	R:R:F280	R:R:W284	56.5351	5.01	Yes	Yes	1	9	8
46	R:R:F280	R:R:L148	27.6114	4.87	Yes	Yes	1	9	8
47	R:R:N319	R:R:Y323	44.1783	5.81	Yes	Yes	1	9	9
48	R:R:L107	R:R:Y313	64.7085	3.52	No	Yes	0	7	7
49	R:R:L107	R:R:S316	64.5764	4.5	No	No	0	7	8
50	L:L:?3	R:R:D137	23.102	13.36	Yes	No	1	0	6
51	R:R:D137	R:R:S110	36.2868	8.83	No	Yes	1	6	6
52	R:R:F113	R:R:S110	13.7837	3.96	No	Yes	1	5	6
53	R:R:F113	R:R:F125	11.6347	6.43	No	No	0	5	7
54	R:R:S110	R:R:V133	18.1786	3.23	Yes	No	1	6	5
55	R:R:V133	R:R:W123	16.2498	6.13	No	Yes	1	5	8
56	L:L:?3	R:R:L134	43.4825	4.54	Yes	No	0	0	5
57	R:R:L134	R:R:S196	59.1333	3	No	No	0	5	5
58	R:R:R131	R:R:S196	55.7953	3.95	No	No	0	6	5
59	R:R:R131	R:R:R197	49.0664	6.4	No	No	0	6	4
60	R:R:F142	R:R:I189	14.4707	5.02	Yes	Yes	0	6	7
61	R:R:T143	R:R:V181	13.2464	4.76	Yes	No	0	6	7
62	R:R:I145	R:R:W284	10.34	5.87	No	Yes	1	7	8
63	R:R:I145	R:R:P235	10.0493	3.39	No	Yes	0	7	9
64	R:R:V181	R:R:Y146	10.6306	6.31	No	No	0	7	5
65	R:R:F280	R:R:I239	61.1503	3.77	Yes	No	0	9	8
66	R:R:V150	R:R:V177	10.6658	4.81	No	No	0	6	5
67	R:R:I239	R:R:S152	57.0196	9.29	No	No	0	8	9
68	R:R:C242	R:R:S152	60.9565	5.16	No	No	0	7	9
69	R:R:S152	R:R:Y243	38.8497	5.09	No	Yes	0	9	9
70	R:R:D154	R:R:Y96	15.5364	10.34	No	Yes	0	8	7
71	R:R:D154	R:R:R169	14.9375	13.1	No	No	0	8	6
72	R:R:C242	R:R:Y156	55.7777	4.03	No	Yes	0	7	8
73	R:R:V160	R:R:Y156	20.8385	8.83	Yes	Yes	5	7	8
74	R:R:H161	R:R:Y156	27.083	6.53	Yes	Yes	5	7	8
75	R:R:H161	R:R:V157	19.0153	2.77	Yes	No	0	7	5
76	R:R:A165	R:R:V157	16.3819	3.39	No	No	0	6	5
77	R:R:A165	R:R:R169	14.8846	2.77	No	No	0	6	6
78	R:R:I95	R:R:P171	11.9517	1.69	Yes	No	0	5	3
79	R:R:F195	R:R:R197	45.6755	2.14	Yes	No	0	5	4
80	R:R:F195	R:R:M212	24.7138	21.15	Yes	Yes	2	5	4
81	R:R:F195	R:R:P213	14.1184	5.78	Yes	No	2	5	4
82	R:R:M212	R:R:W219	10.6923	12.8	Yes	No	2	4	2
83	R:R:P213	R:R:W219	10.613	8.11	No	No	2	4	2
84	R:R:P215	R:R:W219	14.2241	2.7	No	No	0	2	2
85	L:L:?1	R:R:T227	13.678	5.85	Yes	No	1	0	5
86	R:R:T227	R:R:Y288	18.6718	4.99	No	Yes	1	5	7
87	R:R:F228	R:R:Y288	10.7011	5.16	No	Yes	0	5	7
88	R:R:F232	R:R:W284	15.0343	5.01	Yes	Yes	1	8	8
89	R:R:F232	R:R:Y288	11.7492	8.25	Yes	Yes	1	8	7
90	R:R:F232	R:R:V236	11.071	5.24	Yes	No	0	8	6
91	R:R:V273	R:R:Y243	40.3734	5.05	No	Yes	0	7	9
92	R:R:I247	R:R:V273	33.1777	6.14	No	No	0	5	7
93	R:R:I247	R:R:R251	28.3865	6.26	No	No	0	5	5
94	R:R:K249	R:R:V160	13.3962	4.55	No	Yes	0	6	7
95	R:R:K249	R:R:V253	10.2167	4.55	No	No	0	6	6
96	R:R:E266	R:R:R251	25.8675	9.3	No	No	0	6	5
97	R:R:A254	R:R:E266	15.8358	3.02	No	No	0	4	6
98	R:R:A254	R:R:Q260	13.2464	4.55	No	No	0	4	1
99	R:R:L322	R:R:Y323	15.4659	4.69	Yes	Yes	1	8	9
100	R:R:E298	R:R:N294	19.2267	11.83	No	No	0	1	4
101	R:R:N294	R:R:V290	14.5235	4.43	No	No	0	4	4
102	R:R:S308	R:R:V290	12.1455	4.85	No	No	0	6	4
103	R:R:F232	R:R:V281	16.5492	2.62	Yes	No	0	8	5
104	R:R:I282	R:R:V281	12.4361	1.54	No	No	0	5	5
105	R:R:C240	R:R:V236	10.1726	1.71	No	No	0	4	6
106	L:L:?4	L:L:?5	10.2079	51.09	Yes	No	1	0	0
107	L:L:?3	L:L:?4	19.8696	16.98	Yes	Yes	1	0	0
108	R:R:D104	R:R:S316	64.9551	11.78	No	No	0	9	8
109	R:R:R155	R:R:Y323	36.1987	7.2	No	Yes	0	9	9
110	R:R:F142	R:R:M141	36.4277	6.22	Yes	No	1	6	7
111	R:R:L148	R:R:N319	19.3324	4.12	Yes	Yes	1	8	9
112	R:R:R155	R:R:Y243	34.5165	8.23	No	Yes	0	9	9
113	R:R:D137	R:R:Y313	15.1929	4.6	No	Yes	1	6	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:M141	5.61	1	Yes	No	0	7	0	1
L:L:?1	R:R:F142	3.87	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F223	3.87	1	Yes	No	0	6	0	1
L:L:?1	R:R:T227	5.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:F287	7.73	1	Yes	No	0	6	0	1
L:L:?1	R:R:Q291	17.96	1	Yes	No	0	6	0	1
L:L:K2	R:R:L114	4.23	1	Yes	Yes	0	6	0	1
L:L:K2	R:R:F287	4.96	1	Yes	No	0	6	0	1
L:L:?3	R:R:L114	28.39	1	Yes	Yes	0	6	0	1
L:L:?3	R:R:S117	8.62	1	Yes	No	0	6	0	1
L:L:?3	R:R:L134	4.54	1	Yes	No	0	5	0	1
L:L:?3	R:R:D137	13.36	1	Yes	No	0	6	0	1
L:L:?3	R:R:N209	3.38	1	Yes	No	0	5	0	1
L:L:?3	R:R:Y313	3.85	1	Yes	Yes	0	7	0	1
L:L:?4	R:R:A302	7.44	1	Yes	No	0	4	0	1
L:L:?4	R:R:S305	10.63	1	Yes	No	0	4	0	1
L:L:?5	R:R:E298	25.53	1	No	No	0	1	0	1
L:L:?6	R:R:L220	15.67	1	Yes	No	0	5	0	1
L:L:?6	R:R:V224	12.04	1	Yes	No	0	5	0	1
L:L:?6	R:R:V295	9.63	1	Yes	No	0	4	0	1
R:R:L107	R:R:Y313	3.52	0	No	Yes	7	7	2	1
R:R:M108	R:R:Y313	3.59	1	No	Yes	6	7	2	1
R:R:D137	R:R:S110	8.83	1	No	Yes	6	6	1	2
R:R:V111	R:R:Y313	3.79	0	Yes	Yes	7	7	2	1
R:R:I192	R:R:L134	4.28	0	No	No	5	5	2	1
R:R:D137	R:R:Y313	4.6	1	No	Yes	6	7	1	1
R:R:F142	R:R:M141	6.22	1	Yes	No	6	7	1	1
R:R:M141	R:R:W284	9.31	1	No	Yes	7	8	1	2
R:R:F142	R:R:S185	5.28	1	Yes	No	6	8	1	2
R:R:F142	R:R:V188	6.55	1	Yes	No	6	5	1	2
R:R:F142	R:R:I189	5.02	1	Yes	Yes	6	7	1	2
R:R:F142	R:R:T227	9.08	1	Yes	No	6	5	1	1
R:R:F223	R:R:I192	5.02	0	No	No	6	5	1	2
R:R:L220	R:R:Q217	3.99	0	No	No	5	1	1	2
R:R:V221	R:R:V295	4.81	0	No	No	2	4	2	1
R:R:Q291	R:R:V224	4.3	1	No	No	6	5	1	1
R:R:T227	R:R:Y288	4.99	1	No	Yes	5	7	1	2
R:R:W284	R:R:Y288	8.68	1	Yes	Yes	8	7	2	2
R:R:F287	R:R:Q291	12.88	1	No	No	6	6	1	1
R:R:E298	R:R:N294	11.83	0	No	No	1	4	1	2
R:R:F296	R:R:V295	6.55	0	No	No	4	4	2	1
R:R:L134	R:R:S196	3	0	No	No	5	5	1	2
R:R:L114	R:R:V309	2.98	1	Yes	No	6	5	1	2
R:R:L114	R:R:T118	2.95	1	Yes	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IK8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.23
Number of Linked Nodes	259
Number of Links	291
Number of Hubs	34
Number of Links mediated by Hubs	140
Number of Communities	5
Number of Nodes involved in Communities	51
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	40885
Length Of Smallest Path	3
Average Path Length	12.3865
Length of Longest Path	28
Minimum Path Strength	1.225
Average Path Strength	7.35901
Maximum Path Strength	38.31
Minimum Path Correlation	0.7
Average Path Correlation	0.925202
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	52.2456
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.5768
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	DTR
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid (R)-tryptophan DTR
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	6923517
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	TY5
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	TY5
Name	O-benzyl-L-tyrosine
Synonyms
Identifier
Formula	C16 H17 N O3
Molecular Weight	271.311
SMILES
PubChem	725701
Formal Charge	0
Total Atoms	37
Total Chiral Atoms	1
Total Bonds	38
Total Aromatic Bonds	12


Code	PHA
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	PHA
Name	PHENYLALANINAL
Synonyms
Identifier
Formula	C9 H11 N O
Molecular Weight	149.19
SMILES
PubChem	446207
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	22
Total Aromatic Bonds	6


Code	A1D
PDB Residues	L:L:?5
Environment Details	Open EMBL-EBI Page
Code	A1D
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


Code	004
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	004
Name	(2S)-amino(phenyl)ethanoic acid
Synonyms	L-Phenylglycine
Identifier
Formula	C8 H9 N O2
Molecular Weight	151.163
SMILES
PubChem	6931074
Formal Charge	0
Total Atoms	20
Total Chiral Atoms	1
Total Bonds	20
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30872
Sequence	>9IK8_nogp_Chain_R S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y A K M K T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L R H W P F G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H P I K A A R Y R R P T V A K V V N L G V W V L S L L V I L P I V V F S R T A A C N M L M P E P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G W Q Q R K R S E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A E Q D D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F K R S F Q R I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IK8	A	Peptide	Somatostatin	SST1	Homo sapiens	SST analogue	-	Gi1/β1/γ2	2.82	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK8 (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	SST analogue	-		2.82	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK9	A	Peptide	Somatostatin	SST1	Homo sapiens	SST analogue	-	Gi1/β1/γ2	3.37	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK9 (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	SST analogue	-		3.37	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	8XIO	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-		2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-		3.29	2024-07-03	doi.org/10.1073/pnas.2400298121

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