psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	43.71	Yes	Yes	1	0	0
2	L:L:?1	L:L:?3	5.33	Yes	Yes	1	0	0
3	L:L:?1	L:L:?6	5.11	Yes	Yes	1	0	0
4	L:L:?1	L:L:?8	14.88	Yes	Yes	1	0	0
5	L:L:?1	L:L:?9	19.23	Yes	Yes	1	0	0
6	L:L:?1	R:R:D300	17.41	Yes	No	1	0	4
7	L:L:?2	L:L:?3	16.61	Yes	Yes	1	0	0
8	L:L:?2	L:L:?4	3.09	Yes	Yes	1	0	0
9	L:L:?2	L:L:?6	5.97	Yes	Yes	1	0	0
10	L:L:?2	L:L:?7	18.26	Yes	Yes	1	0	0
11	L:L:?2	L:L:?8	3.73	Yes	Yes	1	0	0
12	L:L:?2	R:R:D300	15.27	Yes	No	1	0	4
13	L:L:?3	L:L:?4	34.27	Yes	Yes	1	0	0
14	L:L:?3	L:L:?6	11.21	Yes	Yes	1	0	0
15	L:L:?3	R:R:L220	15.5	Yes	No	0	0	5
16	L:L:?3	R:R:V224	3.57	Yes	No	0	0	5
17	L:L:?4	L:L:K5	13.43	Yes	Yes	1	0	0
18	L:L:?4	L:L:?6	13.15	Yes	Yes	1	0	0
19	L:L:?4	L:L:?7	6.18	Yes	Yes	1	0	0
20	L:L:?4	R:R:F223	8.7	Yes	No	0	0	6
21	L:L:?4	R:R:F287	4.83	Yes	Yes	1	0	6
22	L:L:?4	R:R:Q291	20.07	Yes	No	1	0	6
23	L:L:K5	R:R:L114	2.82	Yes	No	0	0	6
24	L:L:K5	R:R:D137	5.53	Yes	No	1	0	6
25	L:L:K5	R:R:F287	4.96	Yes	Yes	1	0	6
26	L:L:K5	R:R:V309	4.55	Yes	No	0	0	5
27	L:L:K5	R:R:Y313	7.17	Yes	Yes	1	0	7
28	L:L:?6	L:L:?7	22.7	Yes	Yes	1	0	0
29	L:L:?6	L:L:?8	15.87	Yes	Yes	1	0	0
30	L:L:?6	L:L:?9	3.15	Yes	Yes	1	0	0
31	L:L:?6	R:R:N209	12.64	Yes	No	0	0	5
32	L:L:?7	L:L:?8	26.11	Yes	Yes	1	0	0
33	L:L:?7	L:L:?9	3.21	Yes	Yes	1	0	0
34	L:L:?7	R:R:S305	8.45	Yes	No	0	0	4
35	L:L:?8	L:L:?9	22.97	Yes	Yes	1	0	0
36	R:R:A58	R:R:L119	3.15	No	No	0	4	4
37	R:R:I61	R:R:Y65	9.67	No	Yes	0	5	6
38	R:R:S62	R:R:V115	4.85	No	Yes	0	6	6
39	R:R:F63	R:R:S66	3.96	No	No	0	4	5
40	R:R:V111	R:R:Y65	5.05	Yes	Yes	5	7	6
41	R:R:V115	R:R:Y65	18.93	Yes	Yes	5	6	6
42	R:R:I310	R:R:Y65	7.25	No	Yes	0	4	6
43	R:R:C69	R:R:L70	3.17	No	No	0	5	5
44	R:R:C69	R:R:V111	6.83	No	Yes	0	5	7
45	R:R:E105	R:R:L73	15.9	No	No	0	7	6
46	R:R:D104	R:R:N76	20.2	No	No	0	9	9
47	R:R:N76	R:R:P320	9.77	No	Yes	0	9	9
48	R:R:E105	R:R:S77	2.87	No	No	0	7	4
49	R:R:F325	R:R:M78	3.73	Yes	No	0	6	6
50	R:R:A101	R:R:V79	3.39	No	No	0	9	9
51	R:R:P320	R:R:V79	3.53	Yes	No	0	9	9
52	R:R:F330	R:R:V79	6.55	Yes	No	0	8	9
53	R:R:I80	R:R:L84	2.85	No	No	0	7	4
54	R:R:A101	R:R:I80	3.25	No	No	0	9	7
55	R:R:I102	R:R:I80	2.94	No	No	0	7	7
56	R:R:Y81	R:R:Y86	2.98	No	Yes	0	3	5
57	R:R:F330	R:R:V82	9.18	Yes	No	0	8	7
58	R:R:S333	R:R:V82	3.23	No	No	0	5	7
59	R:R:I83	R:R:N94	5.66	No	Yes	2	7	8
60	R:R:I83	R:R:N329	2.83	No	Yes	2	7	7
61	R:R:L84	R:R:L98	2.77	No	No	0	4	5
62	R:R:I337	R:R:Y86	4.84	No	Yes	0	6	5
63	R:R:A87	R:R:N329	3.13	No	Yes	0	6	7
64	R:R:K88	R:R:K90	2.87	No	No	0	6	7
65	R:R:M89	R:R:N94	4.21	No	Yes	0	6	8
66	R:R:N94	R:R:T91	2.92	Yes	No	0	8	7
67	R:R:A92	R:R:Y96	5.34	No	Yes	0	5	7
68	R:R:N94	R:R:T93	4.39	Yes	No	0	8	8
69	R:R:N329	R:R:N94	4.09	Yes	Yes	2	7	8
70	R:R:A174	R:R:I95	6.5	No	Yes	0	7	5
71	R:R:I95	R:R:K175	2.91	Yes	No	0	5	3
72	R:R:I95	R:R:N178	4.25	Yes	No	0	5	8
73	R:R:V150	R:R:Y96	6.31	No	Yes	0	6	7
74	R:R:L151	R:R:Y96	4.69	No	Yes	0	9	7
75	R:R:D154	R:R:Y96	3.45	No	Yes	0	8	7
76	R:R:A174	R:R:Y96	4	No	Yes	0	7	7
77	R:R:I97	R:R:L151	2.85	No	No	0	8	9
78	R:R:C147	R:R:N99	4.72	No	No	0	8	9
79	R:R:N178	R:R:N99	13.62	No	No	0	8	9
80	R:R:N99	R:R:W182	13.56	No	No	0	9	9
81	R:R:C147	R:R:L100	4.76	No	No	0	8	9
82	R:R:L100	R:R:L148	4.15	No	No	0	9	8
83	R:R:I102	R:R:L106	2.85	No	No	0	7	7
84	R:R:A103	R:R:T143	3.36	No	No	0	8	6
85	R:R:A103	R:R:S144	3.42	No	No	0	8	9
86	R:R:D104	R:R:M108	4.16	No	Yes	1	9	6
87	R:R:D104	R:R:S316	8.83	No	No	1	9	8
88	R:R:L106	R:R:N140	13.73	No	Yes	0	7	7
89	R:R:L107	R:R:N140	6.87	Yes	Yes	0	7	7
90	R:R:L107	R:R:M141	4.24	Yes	Yes	0	7	7
91	R:R:L107	R:R:Y313	7.03	Yes	Yes	0	7	7
92	R:R:L107	R:R:S316	4.5	Yes	No	0	7	8
93	R:R:M108	R:R:Y313	3.59	Yes	Yes	1	6	7
94	R:R:M108	R:R:S316	3.07	Yes	No	1	6	8
95	R:R:S110	R:R:V133	3.23	No	No	0	6	5
96	R:R:P112	R:R:V111	3.53	No	Yes	0	8	7
97	R:R:V111	R:R:V115	3.21	Yes	Yes	5	7	6
98	R:R:F113	R:R:W123	4.01	No	Yes	6	5	8
99	R:R:F113	R:R:V133	11.8	No	No	6	5	5
100	R:R:L120	R:R:T116	8.84	No	No	0	4	4
101	R:R:H122	R:R:L120	14.14	No	No	7	5	4
102	R:R:L120	R:R:P124	3.28	No	No	7	4	3
103	R:R:H122	R:R:P124	4.58	No	No	7	5	3
104	R:R:F125	R:R:W123	23.05	No	Yes	0	7	8
105	R:R:G126	R:R:W123	2.81	No	Yes	0	7	8
106	R:R:L129	R:R:W123	3.42	No	Yes	0	5	8
107	R:R:C130	R:R:W123	7.84	No	Yes	0	9	8
108	R:R:V133	R:R:W123	3.68	No	Yes	6	5	8
109	R:R:T198	R:R:W123	3.64	No	Yes	0	5	8
110	R:R:F125	R:R:P124	10.11	No	No	0	7	3
111	R:R:A127	R:R:R131	2.77	No	Yes	0	2	6
112	R:R:C130	R:R:C208	7.28	No	No	0	9	9
113	R:R:R131	R:R:V193	3.92	Yes	No	0	6	4
114	R:R:R131	R:R:S196	5.27	Yes	No	0	6	5
115	R:R:I192	R:R:L134	4.28	No	No	0	5	5
116	R:R:I189	R:R:S135	4.64	Yes	No	0	7	6
117	R:R:S135	R:R:V193	3.23	No	No	0	6	4
118	R:R:N140	R:R:V136	5.91	Yes	No	0	7	4
119	R:R:D137	R:R:Y313	5.75	No	Yes	1	6	7
120	R:R:A138	R:R:I189	6.5	No	Yes	0	4	7
121	R:R:N140	R:R:V139	2.96	Yes	Yes	0	7	5
122	R:R:S185	R:R:V139	6.46	No	Yes	0	8	5
123	R:R:L186	R:R:V139	4.47	No	Yes	0	3	5
124	R:R:I189	R:R:V139	4.61	Yes	Yes	0	7	5
125	R:R:F142	R:R:M141	6.22	Yes	Yes	0	6	7
126	R:R:M141	R:R:W284	6.98	Yes	Yes	1	7	8
127	R:R:M141	R:R:Y288	3.59	Yes	Yes	1	7	7
128	R:R:F142	R:R:S185	5.28	Yes	No	0	6	8
129	R:R:F142	R:R:V188	5.24	Yes	No	0	6	5
130	R:R:F142	R:R:I189	5.02	Yes	Yes	0	6	7
131	R:R:F142	R:R:T227	9.08	Yes	No	0	6	5
132	R:R:T143	R:R:V181	4.76	No	No	0	6	7
133	R:R:T143	R:R:W182	19.41	No	No	0	6	9
134	R:R:I145	R:R:P235	3.39	No	Yes	1	7	9
135	R:R:F280	R:R:I145	3.77	Yes	No	1	9	7
136	R:R:I145	R:R:W284	4.7	No	Yes	1	7	8
137	R:R:V181	R:R:Y146	3.79	No	No	0	7	5
138	R:R:L184	R:R:Y146	5.86	No	No	0	4	5
139	R:R:M230	R:R:Y146	3.59	No	No	0	4	5
140	R:R:P235	R:R:T149	3.5	Yes	No	0	9	7
141	R:R:I239	R:R:S152	6.19	No	No	0	8	9
142	R:R:S152	R:R:Y243	11.45	No	Yes	0	9	9
143	R:R:D154	R:R:R169	14.29	No	No	0	8	6
144	R:R:R155	R:R:Y243	3.09	No	Yes	3	9	9
145	R:R:R155	R:R:Y323	3.09	No	No	3	9	9
146	R:R:H161	R:R:Y156	3.27	Yes	No	0	7	8
147	R:R:L245	R:R:Y156	8.21	No	No	0	4	8
148	R:R:H161	R:R:V157	2.77	Yes	No	0	7	5
149	R:R:A165	R:R:V157	3.39	No	No	0	6	5
150	R:R:A158	R:R:R169	5.53	No	No	0	8	6
151	R:R:V159	R:R:V160	3.21	No	No	0	8	7
152	R:R:H161	R:R:V160	4.15	Yes	No	0	7	7
153	R:R:K249	R:R:V160	4.55	No	No	0	6	7
154	R:R:I163	R:R:K164	7.27	No	No	0	6	4
155	R:R:A165	R:R:R169	2.77	No	No	0	6	6
156	R:R:R167	R:R:Y168	16.46	No	No	0	4	4
157	R:R:P171	R:R:R170	2.88	No	No	0	3	6
158	R:R:G180	R:R:V183	3.68	No	No	0	4	3
159	R:R:L187	R:R:V183	2.98	No	No	0	2	3
160	R:R:L184	R:R:V188	2.98	No	No	0	4	5
161	R:R:V188	R:R:Y226	8.83	No	No	0	5	3
162	R:R:I189	R:R:I192	2.94	Yes	No	0	7	5
163	R:R:F223	R:R:I192	5.02	No	No	0	6	5
164	R:R:F195	R:R:M212	14.93	No	Yes	4	5	4
165	R:R:F195	R:R:P213	8.67	No	No	4	5	4
166	R:R:A207	R:R:N209	3.13	No	No	0	5	5
167	R:R:M210	R:R:M212	8.66	No	Yes	0	4	4
168	R:R:L220	R:R:M210	4.24	No	No	0	5	4
169	R:R:M212	R:R:P213	5.03	Yes	No	4	4	4
170	R:R:M212	R:R:W219	22.1	Yes	No	4	4	2
171	R:R:P213	R:R:W219	20.27	No	No	4	4	2
172	R:R:P215	R:R:R218	12.97	No	No	0	2	1
173	R:R:Q217	R:R:V221	2.87	No	Yes	0	1	2
174	R:R:V221	R:R:V295	3.21	Yes	No	8	2	4
175	R:R:F296	R:R:V221	7.87	No	Yes	8	4	2
176	R:R:L225	R:R:V224	2.98	No	No	0	5	5
177	R:R:Q291	R:R:V224	5.73	No	No	0	6	5
178	R:R:L225	R:R:L292	4.15	No	No	0	5	5
179	R:R:T227	R:R:Y288	6.24	No	Yes	0	5	7
180	R:R:F228	R:R:F232	4.29	No	No	0	5	8
181	R:R:F228	R:R:L233	7.31	No	No	0	5	4
182	R:R:F228	R:R:Y288	7.22	No	Yes	0	5	7
183	R:R:L229	R:R:M230	5.65	No	No	0	4	4
184	R:R:F232	R:R:M285	9.95	No	No	0	8	5
185	R:R:L234	R:R:P235	4.93	No	Yes	0	4	9
186	R:R:F280	R:R:P235	2.89	Yes	Yes	1	9	9
187	R:R:F280	R:R:V236	3.93	Yes	No	0	9	6
188	R:R:F280	R:R:I239	3.77	Yes	No	0	9	8
189	R:R:C242	R:R:L241	3.17	No	No	0	7	4
190	R:R:L241	R:R:L245	5.54	No	No	0	4	4
191	R:R:V273	R:R:Y243	5.05	Yes	Yes	0	7	9
192	R:R:V276	R:R:Y243	5.05	Yes	Yes	3	8	9
193	R:R:V277	R:R:Y243	3.79	No	Yes	0	7	9
194	R:R:Y243	R:R:Y323	2.98	Yes	No	3	9	9
195	R:R:I247	R:R:R251	5.01	No	No	0	5	5
196	R:R:I247	R:R:T270	3.04	No	No	0	5	7
197	R:R:E266	R:R:M250	10.83	Yes	No	0	6	8
198	R:R:I269	R:R:M250	8.75	No	No	0	7	8
199	R:R:E266	R:R:R251	11.63	Yes	No	0	6	5
200	R:R:A254	R:R:Q260	4.55	No	No	0	4	1
201	R:R:K256	R:R:L255	4.23	No	No	0	3	4
202	R:R:A257	R:R:W259	5.19	No	No	0	4	3
203	R:R:Q260	R:R:W259	19.71	No	No	0	1	3
204	R:R:K263	R:R:R262	8.66	No	No	0	2	3
205	R:R:E266	R:R:K263	16.2	Yes	No	0	6	2
206	R:R:I269	R:R:K268	5.82	No	No	0	7	7
207	R:R:L326	R:R:M272	2.83	No	No	0	6	8
208	R:R:L322	R:R:M275	5.65	No	No	0	8	6
209	R:R:L322	R:R:V276	2.98	No	Yes	0	8	8
210	R:R:V276	R:R:Y323	5.05	Yes	No	3	8	9
211	R:R:C283	R:R:N315	3.15	No	No	0	9	9
212	R:R:W284	R:R:Y288	3.86	Yes	Yes	1	8	7
213	R:R:G312	R:R:W284	8.44	No	Yes	0	7	8
214	R:R:N315	R:R:W284	5.65	No	Yes	0	9	8
215	R:R:M285	R:R:P286	3.35	No	No	0	5	9
216	R:R:F287	R:R:Y288	6.19	Yes	Yes	1	6	7
217	R:R:F287	R:R:Q291	12.88	Yes	No	1	6	6
218	R:R:S308	R:R:V290	4.85	No	No	0	6	4
219	R:R:N294	R:R:V293	2.96	No	No	0	4	5
220	R:R:D300	R:R:N294	6.73	No	No	0	4	4
221	R:R:F296	R:R:V295	6.55	No	No	8	4	4
222	R:R:D301	R:R:V304	5.84	No	No	0	4	4
223	R:R:Q306	R:R:T303	5.67	No	No	0	4	2
224	R:R:I310	R:R:L307	2.85	No	No	0	4	4
225	R:R:L307	R:R:L311	4.15	No	No	0	4	7
226	R:R:N315	R:R:N319	5.45	No	No	0	9	9
227	R:R:F325	R:R:P320	2.89	Yes	Yes	0	6	9
228	R:R:F330	R:R:G324	4.52	Yes	No	0	8	7
229	R:R:F325	R:R:F330	13.93	Yes	Yes	0	6	8
230	R:R:D328	R:R:S327	2.94	No	No	2	5	8
231	R:R:N329	R:R:S327	7.45	Yes	No	2	7	8
232	R:R:D328	R:R:N329	5.39	No	Yes	2	5	7
233	R:R:F330	R:R:F334	4.29	Yes	No	0	8	5
234	R:R:R332	R:R:S333	7.91	No	No	0	5	5
235	R:R:L338	R:R:W342	14.81	No	No	0	6	3
236	R:R:D344	R:R:N345	8.08	No	No	0	2	3
237	R:R:F287	R:R:S308	2.64	Yes	No	0	6	6
238	R:R:S333	R:R:Y86	2.54	No	Yes	0	5	5
239	R:R:V309	R:R:Y65	2.52	No	Yes	0	5	6
240	R:R:F330	R:R:I83	2.51	Yes	No	0	8	7
241	R:R:F325	R:R:I321	2.51	Yes	No	0	6	7
242	R:R:F296	R:R:L292	2.44	No	No	0	4	5
243	R:R:L119	R:R:R121	2.43	No	No	0	4	4
244	R:R:L211	R:R:R197	2.43	No	No	0	4	4
245	R:R:Q261	R:R:W259	2.19	No	No	0	3	3
246	R:R:R131	R:R:R197	2.13	Yes	No	0	6	4
247	R:R:R332	R:R:R336	2.13	No	No	0	5	4
248	R:R:R85	R:R:Y86	2.06	No	Yes	0	4	5
249	R:R:G75	R:R:P320	2.03	No	Yes	0	8	9
250	R:R:G231	R:R:P235	2.03	No	Yes	0	5	9
251	R:R:C317	R:R:G72	1.96	No	No	0	7	8
252	R:R:C74	R:R:G75	1.96	No	No	0	4	8
253	R:R:G222	R:R:V221	1.84	No	Yes	0	4	2
254	R:R:A318	R:R:C317	1.81	No	No	0	5	7
255	R:R:A199	R:R:A207	1.79	No	No	0	3	5
256	R:R:C130	R:R:S196	1.72	No	No	0	9	5
257	R:R:C242	R:R:V153	1.71	No	No	0	7	6
258	R:R:G180	R:R:L179	1.71	No	No	0	4	4
259	R:R:C240	R:R:V277	1.71	No	No	0	4	7
260	R:R:G72	R:R:N76	1.7	No	No	0	8	9
261	R:R:A297	R:R:V293	1.7	No	No	0	3	5
262	R:R:I95	R:R:P171	1.69	Yes	No	0	5	3
263	R:R:I163	R:R:P162	1.69	No	No	0	6	7
264	R:R:L190	R:R:P191	1.64	No	No	0	3	6
265	R:R:S66	R:R:V67	1.62	No	No	0	5	5
266	R:R:A248	R:R:M252	1.61	No	No	0	3	5
267	R:R:V67	R:R:V71	1.6	No	No	0	5	5
268	R:R:V150	R:R:V177	1.6	No	Yes	0	6	5
269	R:R:V173	R:R:V177	1.6	No	Yes	0	5	5
270	R:R:V176	R:R:V177	1.6	No	Yes	0	3	5
271	R:R:V177	R:R:V181	1.6	Yes	No	0	5	7
272	R:R:V289	R:R:V290	1.6	No	No	0	6	4
273	R:R:T118	R:R:V115	1.59	No	Yes	0	4	6
274	R:R:T172	R:R:V173	1.59	No	No	0	3	5
275	R:R:A216	R:R:L220	1.58	No	No	0	3	5
276	R:R:I64	R:R:V68	1.54	No	No	0	5	7
277	R:R:I246	R:R:V159	1.54	No	No	0	9	8
278	R:R:I247	R:R:V273	1.54	No	Yes	0	5	7
279	R:R:I269	R:R:V273	1.54	No	Yes	0	7	7
280	R:R:I282	R:R:V281	1.54	No	No	0	5	5
281	R:R:H161	R:R:P162	1.53	Yes	No	0	7	7
282	R:R:M108	R:R:V68	1.52	Yes	No	0	6	7
283	R:R:K249	R:R:V253	1.52	No	No	0	6	6
284	R:R:M272	R:R:V276	1.52	No	Yes	0	8	8
285	R:R:M274	R:R:V273	1.52	No	Yes	0	5	7
286	R:R:M278	R:R:V281	1.52	No	No	0	5	5
287	R:R:M285	R:R:V281	1.52	No	No	0	5	5
288	R:R:A302	R:R:Q306	1.52	No	No	0	4	4
289	R:R:A254	R:R:E266	1.51	No	Yes	0	4	6
290	R:R:L114	R:R:S117	1.5	No	No	0	6	6
291	R:R:L132	R:R:V136	1.49	No	No	0	4	4
292	R:R:L322	R:R:V279	1.49	No	No	0	8	7
293	R:R:L119	R:R:T118	1.47	No	No	0	4	4
294	R:R:D301	R:R:T303	1.45	No	No	0	4	2
295	R:R:I64	R:R:L60	1.43	No	No	0	5	5
296	R:R:I337	R:R:L340	1.43	No	No	0	6	5
297	R:R:L109	R:R:L73	1.38	No	No	0	5	6
298	R:R:L128	R:R:L129	1.38	No	No	0	1	5
299	R:R:R264	R:R:S265	1.32	No	No	0	4	5
300	R:R:K263	R:R:R267	1.24	No	No	0	2	4
301	R:R:Q260	R:R:R264	1.17	No	No	0	1	4
302	R:R:Q261	R:R:R264	1.17	No	No	0	3	4
303	R:R:M343	R:R:W342	1.16	No	No	0	5	3
304	R:R:Q306	R:R:Y65	1.13	No	Yes	0	4	6
305	R:R:R218	R:R:W219	1	No	No	0	1	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	17.6117	6	1	0
2	L:L:?2	15.2343	7	1	0
3	L:L:?3	14.415	6	1	0
4	L:L:?4	12.965	8	1	0
5	L:L:K5	6.41	6	1	0
6	L:L:?6	11.225	8	1	0
7	L:L:?7	14.1517	6	1	0
8	L:L:?8	16.712	5	1	0
9	L:L:?9	12.14	4	1	0
10	R:R:Y65	7.425	6	5	6
11	R:R:Y86	3.105	4	0	5
12	R:R:N94	4.254	5	2	8
13	R:R:I95	3.8375	4	0	5
14	R:R:Y96	4.758	5	0	7
15	R:R:L107	5.66	4	0	7
16	R:R:M108	3.085	4	1	6
17	R:R:V111	4.655	4	5	7
18	R:R:V115	7.145	4	5	6
19	R:R:W123	6.92143	7	6	8
20	R:R:R131	3.5225	4	0	6
21	R:R:V139	4.625	4	0	5
22	R:R:N140	7.3675	4	0	7
23	R:R:M141	5.2575	4	1	7
24	R:R:F142	6.168	5	0	6
25	R:R:H161	2.93	4	0	7
26	R:R:V177	1.6	4	0	5
27	R:R:I189	4.742	5	0	7
28	R:R:M212	12.68	4	4	4
29	R:R:V221	3.9475	4	8	2
30	R:R:P235	3.348	5	1	9
31	R:R:Y243	5.235	6	3	9
32	R:R:E266	10.0425	4	0	6
33	R:R:V273	2.4125	4	0	7
34	R:R:V276	3.65	4	3	8
35	R:R:F280	3.59	4	1	9
36	R:R:W284	5.926	5	1	8
37	R:R:F287	6.3	5	1	6
38	R:R:Y288	5.42	5	1	7
39	R:R:Y313	5.885	4	1	7
40	R:R:P320	4.555	4	0	9
41	R:R:F325	5.765	4	0	6
42	R:R:N329	4.578	5	2	7
43	R:R:F330	6.83	6	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?2	L:L:?4	12.4001	3.09	Yes	Yes	1	0	0
2	L:L:?3	L:L:?4	24.5824	34.27	Yes	Yes	1	0	0
3	L:L:?4	L:L:?6	12.2888	13.15	Yes	Yes	1	0	0
4	L:L:?3	R:R:L220	17.4696	15.5	Yes	No	0	0	5
5	L:L:?4	L:L:K5	25.6718	13.43	Yes	Yes	1	0	0
6	L:L:?4	R:R:F223	19.2127	8.7	Yes	No	0	0	6
7	L:L:?4	R:R:F287	27.1292	4.83	Yes	Yes	1	0	6
8	R:R:Q291	R:R:V224	16.3172	5.73	No	No	0	6	5
9	L:L:K5	R:R:V309	40.6285	4.55	Yes	No	0	0	5
10	L:L:K5	R:R:Y313	36.7598	7.17	Yes	Yes	1	0	7
11	R:R:V309	R:R:Y65	38.8273	2.52	No	Yes	0	5	6
12	R:R:V115	R:R:Y65	11.9353	18.93	Yes	Yes	5	6	6
13	R:R:M108	R:R:Y313	29.1193	3.59	Yes	Yes	1	6	7
14	R:R:D104	R:R:M108	24.3403	4.16	No	Yes	1	9	6
15	R:R:D104	R:R:N76	59.0374	20.2	No	No	0	9	9
16	R:R:N76	R:R:P320	54.6797	9.77	No	Yes	0	9	9
17	R:R:F325	R:R:P320	26.9452	2.89	Yes	Yes	0	6	9
18	R:R:L107	R:R:Y313	16.6562	7.03	Yes	Yes	0	7	7
19	R:R:L107	R:R:N140	14.4579	6.87	Yes	Yes	0	7	7
20	R:R:L106	R:R:N140	14.2788	13.73	No	Yes	0	7	7
21	R:R:I102	R:R:L106	12.6132	2.85	No	No	0	7	7
22	R:R:I102	R:R:I80	10.9766	2.94	No	No	0	7	7
23	R:R:P320	R:R:V79	24.5921	3.53	Yes	No	0	9	9
24	R:R:F330	R:R:V79	26.7661	6.55	Yes	No	0	8	9
25	R:R:F325	R:R:F330	23.1104	13.93	Yes	Yes	0	6	8
26	R:R:F330	R:R:V82	21.7305	9.18	Yes	No	0	8	7
27	R:R:S333	R:R:V82	19.3386	3.23	No	No	0	5	7
28	R:R:S333	R:R:Y86	12.1048	2.54	No	Yes	0	5	5
29	R:R:F330	R:R:I83	21.8709	2.51	Yes	No	0	8	7
30	R:R:F223	R:R:I192	18.7382	5.02	No	No	0	6	5
31	R:R:I189	R:R:I192	19.8712	2.94	Yes	No	0	7	5
32	R:R:F142	R:R:I189	32.1793	5.02	Yes	Yes	0	6	7
33	R:R:F142	R:R:V188	100	5.24	Yes	No	0	6	5
34	R:R:L184	R:R:V188	96.8237	2.98	No	No	0	4	5
35	R:R:L184	R:R:Y146	95.1629	5.86	No	No	0	4	5
36	R:R:V181	R:R:Y146	90.1225	3.79	No	No	0	7	5
37	R:R:V177	R:R:V181	64.044	1.6	Yes	No	0	5	7
38	R:R:V150	R:R:V177	56.7327	1.6	No	Yes	0	6	5
39	R:R:V150	R:R:Y96	54.9073	6.31	No	Yes	0	6	7
40	R:R:F287	R:R:Y288	60.1026	6.19	Yes	Yes	1	6	7
41	R:R:M141	R:R:Y288	26.7274	3.59	Yes	Yes	1	7	7
42	R:R:F142	R:R:M141	74.9528	6.22	Yes	Yes	0	6	7
43	R:R:T227	R:R:Y288	23.0281	6.24	No	Yes	0	5	7
44	R:R:F142	R:R:T227	22.8151	9.08	Yes	No	0	6	5
45	R:R:A174	R:R:Y96	11.0347	4	No	Yes	0	7	7
46	R:R:T143	R:R:V181	25.7202	4.76	No	No	0	6	7
47	R:R:T143	R:R:W182	19.6775	19.41	No	No	0	6	9
48	R:R:N99	R:R:W182	17.7601	13.56	No	No	0	9	9
49	R:R:N178	R:R:N99	10.4585	13.62	No	No	0	8	9
50	R:R:D154	R:R:Y96	38.5804	3.45	No	Yes	0	8	7
51	R:R:L107	R:R:S316	40.459	4.5	Yes	No	0	7	8
52	R:R:I189	R:R:S135	32.0583	4.64	Yes	No	0	7	6
53	R:R:S135	R:R:V193	30.7026	3.23	No	No	0	6	4
54	R:R:R131	R:R:V193	29.3371	3.92	Yes	No	0	6	4
55	R:R:R131	R:R:S196	23.7786	5.27	Yes	No	0	6	5
56	R:R:C130	R:R:S196	22.3648	1.72	No	No	0	9	5
57	R:R:C130	R:R:W123	19.5081	7.84	No	Yes	0	9	8
58	R:R:I189	R:R:V139	11.5092	4.61	Yes	Yes	0	7	5
59	R:R:W284	R:R:Y288	21.561	3.86	Yes	Yes	1	8	7
60	R:R:I145	R:R:W284	61.7925	4.7	No	Yes	1	7	8
61	R:R:F280	R:R:I145	56.0403	3.77	Yes	No	1	9	7
62	R:R:F280	R:R:I239	54.946	3.77	Yes	No	0	9	8
63	R:R:I239	R:R:S152	53.9292	6.19	No	No	0	8	9
64	R:R:S152	R:R:Y243	52.9027	11.45	No	Yes	0	9	9
65	R:R:D154	R:R:R169	36.6242	14.29	No	No	0	8	6
66	R:R:A165	R:R:R169	32.6829	2.77	No	No	0	6	6
67	R:R:A165	R:R:V157	30.6977	3.39	No	No	0	6	5
68	R:R:H161	R:R:V157	28.7029	2.77	Yes	No	0	7	5
69	R:R:H161	R:R:Y156	10.5505	3.27	Yes	No	0	7	8
70	R:R:H161	R:R:V160	10.3133	4.15	Yes	No	0	7	7
71	R:R:L220	R:R:M210	13.6542	4.24	No	No	0	5	4
72	R:R:M210	R:R:M212	11.732	8.66	No	Yes	0	4	4
73	R:R:L225	R:R:V224	19.755	2.98	No	No	0	5	5
74	R:R:L225	R:R:L292	16.9612	4.15	No	No	0	5	5
75	R:R:F296	R:R:L292	14.1578	2.44	No	No	0	4	5
76	R:R:F228	R:R:Y288	14.792	7.22	No	Yes	0	5	7
77	R:R:F228	R:R:F232	11.1509	4.29	No	No	0	5	8
78	R:R:V273	R:R:Y243	41.0546	5.05	Yes	Yes	0	7	9
79	R:R:I247	R:R:V273	19.3967	1.54	No	Yes	0	5	7
80	R:R:I247	R:R:R251	16.9854	5.01	No	No	0	5	5
81	R:R:E266	R:R:R251	15.7265	11.63	Yes	No	0	6	5
82	R:R:I269	R:R:V273	19.3919	1.54	No	Yes	0	7	7
83	R:R:I269	R:R:M250	16.9757	8.75	No	No	0	7	8
84	R:R:E266	R:R:M250	15.8088	10.83	Yes	No	0	6	8
85	R:R:A254	R:R:E266	21.2124	1.51	No	Yes	0	4	6
86	R:R:A254	R:R:Q260	18.6026	4.55	No	No	0	4	1
87	R:R:Q306	R:R:Y65	10.0663	1.13	No	Yes	0	4	6
88	L:L:K5	R:R:F287	27.1825	4.96	Yes	Yes	1	0	6
89	R:R:F287	R:R:Q291	12.6325	12.88	Yes	No	1	6	6
90	R:R:L107	R:R:M141	55.2898	4.24	Yes	Yes	0	7	7
91	R:R:N140	R:R:V139	13.3879	2.96	Yes	Yes	0	7	5
92	R:R:M141	R:R:W284	44.8264	6.98	Yes	Yes	1	7	8
93	R:R:D104	R:R:S316	35.7672	8.83	No	No	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D300	17.41	1	Yes	No	0	4	0	1
L:L:?2	R:R:D300	15.27	1	Yes	No	0	4	0	1
L:L:?3	R:R:L220	15.5	1	Yes	No	0	5	0	1
L:L:?3	R:R:V224	3.57	1	Yes	No	0	5	0	1
L:L:?4	R:R:F223	8.7	1	Yes	No	0	6	0	1
L:L:?4	R:R:F287	4.83	1	Yes	Yes	0	6	0	1
L:L:?4	R:R:Q291	20.07	1	Yes	No	0	6	0	1
L:L:K5	R:R:L114	2.82	1	Yes	No	0	6	0	1
L:L:K5	R:R:D137	5.53	1	Yes	No	0	6	0	1
L:L:K5	R:R:F287	4.96	1	Yes	Yes	0	6	0	1
L:L:K5	R:R:V309	4.55	1	Yes	No	0	5	0	1
L:L:K5	R:R:Y313	7.17	1	Yes	Yes	0	7	0	1
L:L:?6	R:R:N209	12.64	1	Yes	No	0	5	0	1
L:L:?7	R:R:S305	8.45	1	Yes	No	0	4	0	1
R:R:L107	R:R:Y313	7.03	0	Yes	Yes	7	7	2	1
R:R:M108	R:R:Y313	3.59	1	Yes	Yes	6	7	2	1
R:R:D137	R:R:Y313	5.75	1	No	Yes	6	7	1	1
R:R:F223	R:R:I192	5.02	0	No	No	6	5	1	2
R:R:A207	R:R:N209	3.13	0	No	No	5	5	2	1
R:R:L220	R:R:M210	4.24	0	No	No	5	4	1	2
R:R:L225	R:R:V224	2.98	0	No	No	5	5	2	1
R:R:Q291	R:R:V224	5.73	1	No	No	6	5	1	1
R:R:F287	R:R:Y288	6.19	1	Yes	Yes	6	7	1	2
R:R:F287	R:R:Q291	12.88	1	Yes	No	6	6	1	1
R:R:D300	R:R:N294	6.73	1	No	No	4	4	1	2
R:R:F287	R:R:S308	2.64	1	Yes	No	6	6	1	2
R:R:V309	R:R:Y65	2.52	0	No	Yes	5	6	1	2
R:R:A216	R:R:L220	1.58	0	No	No	3	5	2	1
R:R:L114	R:R:S117	1.5	0	No	No	6	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IK9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	274
Number of Links	305
Number of Hubs	43
Number of Links mediated by Hubs	165
Number of Communities	8
Number of Nodes involved in Communities	48
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	52321
Length Of Smallest Path	3
Average Path Length	14.4563
Length of Longest Path	33
Minimum Path Strength	1.17
Average Path Strength	6.16293
Maximum Path Strength	31.47
Minimum Path Correlation	0.7
Average Path Correlation	0.942105
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	52.0862
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.3305
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • somatostatin receptor activity • neuropeptide receptor activity • neuropeptide binding • peptide binding • neuropeptide signaling pathway • developmental process • multicellular organismal process • head development • forebrain development • animal organ development • brain development • nervous system development • multicellular organism development • central nervous system development • anatomical structure development • system development • spermatogenesis • sexual reproduction • reproductive process • multicellular organismal reproductive process • developmental process involved in reproduction • male gamete generation • gamete generation • negative regulation of cell population proliferation • regulation of cell population proliferation • negative regulation of cellular process • negative regulation of biological process • response to estradiol • cellular response to estradiol stimulus • cell surface receptor signaling pathway • glutamate receptor signaling pathway • cerebellum development • metencephalon development • hindbrain development • response to peptide • response to cytokine • response to leukemia inhibitory factor • cellular response to cytokine stimulus • cellular response to leukemia inhibitory factor • response to nutrient levels • response to stress • response to starvation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • system process • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	4J2
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	4J2
Name	(2R)-2-amino-3-(naphthalen-2-yl)propanoic acid
Synonyms
Identifier
Formula	C13 H13 N O2
Molecular Weight	215.248
SMILES
PubChem	2733661
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	30
Total Aromatic Bonds	11


Code	DCY
PDB Residues	L:L:?2 L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DCY
Name	D-Cysteine
Synonyms	D-Cysteine hydrochloride monohydrate
Identifier
Formula	C3 H7 N O2 S
Molecular Weight	121.158
SMILES
PubChem	6419721
Formal Charge	0
Total Atoms	14
Total Chiral Atoms	1
Total Bonds	13
Total Aromatic Bonds	0


Code	DTY
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	DTY
Name	D-Tyrosine
Synonyms	(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid D-Tyrosine D-Tyrosin D-Tyr (R)-3-(p-Hydroxyphenyl)alanine
Identifier
Formula	C9 H11 N O3
Molecular Weight	181.189
SMILES
PubChem	71098
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


Code	DTR
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	DTR
Name	D-Tryptophan
Synonyms	(R)-tryptophan DTR D-Tryptophan (2R)-2-amino-3-(1H-indol-3-yl)propanoic acid
Identifier
Formula	C11 H12 N2 O2
Molecular Weight	204.225
SMILES
PubChem	9060
Formal Charge	0
Total Atoms	27
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	10


Code	DVA
PDB Residues	L:L:?6
Environment Details	Open EMBL-EBI Page
Code	DVA
Name	D-VALINE
Synonyms
Identifier
Formula	C5 H11 N O2
Molecular Weight	117.146
SMILES
PubChem	6971095
Formal Charge	0
Total Atoms	19
Total Chiral Atoms	1
Total Bonds	18
Total Aromatic Bonds	0


Code	ALO
PDB Residues	L:L:?8
Environment Details	Open EMBL-EBI Page
Code	ALO
Name	ALLO-THREONINE
Synonyms
Identifier
Formula	C4 H9 N O3
Molecular Weight	119.119
SMILES
PubChem	6995276
Formal Charge	0
Total Atoms	17
Total Chiral Atoms	2
Total Bonds	16
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P30872
Sequence	>9IK9_nogp_Chain_R S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y A K M K T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L R H W P F G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H P I K A A R Y R R P T V A K V V N L G V W V L S L L V I L P I V V F S R T A A C N M L M P E P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G W Q Q R K R S E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A E Q D D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F K R S F Q R I L C L S W M D N A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XIO	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIO (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	L797591	-		2.65	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-	chim(NtGi1-Gs-CtGi1)/β1/γ2	3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	8XIP (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-		3.29	2024-07-03	doi.org/10.1073/pnas.2400298121
	9IK8	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-	Gi1/β1/γ2	2.82	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK8 (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Pasireotide	-		2.82	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK9	A	Peptide	Somatostatin	SST1	Homo sapiens	Lanreotide	-	Gi1/β1/γ2	3.37	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043
	9IK9 (No Gprot)	A	Peptide	Somatostatin	SST1	Homo sapiens	Lanreotide	-		3.37	2025-04-30	doi.org/10.1016/j.apsb.2025.03.043

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