psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F48	R:R:L44	3.65	No	No	0	4	5
2	R:R:P46	R:R:V45	3.53	No	Yes	0	6	5
3	R:R:F49	R:R:V45	5.24	Yes	Yes	1	7	5
4	R:R:L102	R:R:V45	5.96	No	Yes	1	5	5
5	R:R:F49	R:R:F98	4.29	Yes	Yes	1	7	6
6	R:R:F49	R:R:L102	4.87	Yes	No	1	7	5
7	R:R:F49	R:R:Y313	9.28	Yes	Yes	1	7	7
8	R:R:L92	R:R:M53	5.65	No	No	0	7	7
9	R:R:L57	R:R:S61	4.5	No	No	0	6	4
10	R:R:G59	R:R:P320	4.06	No	No	0	8	9
11	R:R:A85	R:R:N60	4.69	No	No	0	9	9
12	R:R:D88	R:R:N60	12.12	No	No	0	9	9
13	R:R:N60	R:R:P320	6.52	No	No	0	9	9
14	R:R:F334	R:R:L62	8.53	No	No	0	6	6
15	R:R:A85	R:R:V63	3.39	No	No	0	9	9
16	R:R:F330	R:R:V63	6.55	Yes	No	0	8	9
17	R:R:H70	R:R:Y65	30.49	No	No	0	5	4
18	R:R:F330	R:R:V66	5.24	Yes	No	0	8	7
19	R:R:F334	R:R:V66	5.24	No	No	0	6	7
20	R:R:V337	R:R:V66	4.81	No	No	0	6	7
21	R:R:I67	R:R:N78	5.66	Yes	No	0	7	8
22	R:R:A82	R:R:I67	4.87	No	Yes	0	6	7
23	R:R:F330	R:R:I67	3.77	Yes	Yes	0	8	7
24	R:R:H70	R:R:R69	14.67	No	No	0	5	5
25	R:R:H70	R:R:V337	5.54	No	No	0	5	6
26	R:R:K71	R:R:P72	11.71	No	No	0	6	5
27	R:R:K71	R:R:M73	8.64	No	No	0	6	7
28	R:R:M73	R:R:N78	9.82	No	No	0	7	8
29	R:R:N78	R:R:T75	5.85	No	No	0	8	7
30	R:R:R154	R:R:V76	14.38	Yes	No	0	7	6
31	R:R:P156	R:R:V76	3.53	No	No	0	1	6
32	R:R:R154	R:R:T77	6.47	Yes	No	0	7	8
33	R:R:A159	R:R:F79	5.55	No	No	0	7	6
34	R:R:F79	R:R:L160	4.87	No	No	0	6	3
35	R:R:D139	R:R:Y80	10.34	No	No	0	8	7
36	R:R:A159	R:R:Y80	4	No	No	0	7	7
37	R:R:V162	R:R:Y80	5.05	No	No	0	5	7
38	R:R:N83	R:R:T87	4.39	No	Yes	0	9	8
39	R:R:N83	R:R:S163	10.43	No	No	0	9	8
40	R:R:L84	R:R:T132	4.42	No	No	0	9	8
41	R:R:L84	R:R:M136	5.65	No	No	0	9	9
42	R:R:T132	R:R:T87	9.42	No	Yes	0	8	8
43	R:R:T87	R:R:W167	4.85	Yes	No	0	8	9
44	R:R:D88	R:R:S316	8.83	No	No	0	9	9
45	R:R:T90	R:R:W167	8.49	No	No	0	6	9
46	R:R:F91	R:R:S125	6.61	Yes	No	1	7	8
47	R:R:F91	R:R:W276	5.01	Yes	Yes	1	7	8
48	R:R:F91	R:R:S312	3.96	Yes	No	1	7	7
49	R:R:F91	R:R:Y313	4.13	Yes	Yes	1	7	7
50	R:R:F91	R:R:S316	6.61	Yes	No	0	7	9
51	R:R:L92	R:R:S316	6.01	No	No	0	7	9
52	R:R:C94	R:R:I121	6.55	No	No	0	4	5
53	R:R:C94	R:R:Q122	7.63	No	No	1	4	6
54	R:R:C94	R:R:S125	5.16	No	No	1	4	8
55	R:R:C95	R:R:Y313	14.79	No	Yes	0	7	7
56	R:R:P97	R:R:V96	3.53	No	No	0	9	8
57	R:R:P97	R:R:V118	5.3	No	No	0	9	5
58	R:R:F98	R:R:L101	8.53	Yes	No	0	6	4
59	R:R:F98	R:R:L102	9.74	Yes	No	1	6	5
60	R:R:F98	R:R:H309	21.5	Yes	No	1	6	6
61	R:R:F98	R:R:Y313	4.13	Yes	Yes	1	6	7
62	L:L:L218	R:R:F98	4.87	No	Yes	0	0	6
63	L:L:N214	R:R:L101	6.87	No	No	0	0	4
64	L:L:G217	R:R:L101	3.42	No	No	0	0	4
65	R:R:P104	R:R:Y103	9.74	No	No	0	5	5
66	L:L:N214	R:R:G107	5.09	No	No	0	0	5
67	R:R:L110	R:R:W108	12.53	No	No	0	7	8
68	R:R:C115	R:R:W108	3.92	No	No	0	9	8
69	R:R:L110	R:R:M114	5.65	No	No	0	7	6
70	R:R:D112	R:R:K116	8.3	No	No	0	3	7
71	R:R:D112	R:R:L183	4.07	No	No	0	3	3
72	R:R:C115	R:R:C191	7.28	No	No	0	9	9
73	L:L:L218	R:R:V118	7.45	No	No	0	0	5
74	R:R:H181	R:R:N119	28.06	Yes	No	0	5	5
75	L:L:L218	R:R:N119	6.87	No	No	0	0	5
76	R:R:V124	R:R:Y120	8.83	No	Yes	2	5	6
77	R:R:S174	R:R:Y120	3.82	No	Yes	2	7	6
78	R:R:L178	R:R:Y120	9.38	No	Yes	0	5	6
79	R:R:Q122	R:R:S125	4.33	No	No	1	6	8
80	R:R:Q123	R:R:S174	5.78	Yes	No	2	4	7
81	R:R:Q123	R:R:V177	5.73	Yes	No	0	4	5
82	R:R:F204	R:R:Q123	3.51	Yes	Yes	2	5	4
83	R:R:N208	R:R:Q123	3.96	Yes	Yes	2	5	4
84	L:L:R219	R:R:Q123	7.01	Yes	Yes	2	0	4
85	R:R:S170	R:R:V124	4.85	No	No	0	7	5
86	R:R:S174	R:R:V124	6.46	No	No	2	7	5
87	R:R:L212	R:R:V126	4.47	Yes	No	0	6	7
88	R:R:V126	R:R:W276	8.58	No	Yes	0	7	8
89	L:L:F220	R:R:V126	13.11	Yes	No	0	0	7
90	R:R:Q127	R:R:W131	12.05	Yes	No	0	6	6
91	R:R:Q127	R:R:V173	5.73	Yes	No	4	6	5
92	R:R:Q127	R:R:Y207	5.64	Yes	No	4	6	4
93	R:R:L212	R:R:Q127	9.32	Yes	Yes	0	6	6
94	R:R:A128	R:R:W167	7.78	No	No	0	7	9
95	R:R:I166	R:R:W131	3.52	No	No	0	7	6
96	R:R:F272	R:R:L133	3.65	Yes	No	0	9	8
97	R:R:L133	R:R:Y323	4.69	No	Yes	0	8	9
98	R:R:P216	R:R:T134	3.5	No	No	0	9	7
99	R:R:M136	R:R:Y323	5.99	No	Yes	0	9	9
100	R:R:S137	R:R:T220	9.59	No	No	6	9	8
101	R:R:S137	R:R:Y224	11.45	No	Yes	6	9	9
102	R:R:D139	R:R:V143	4.38	No	No	3	8	8
103	R:R:D139	R:R:R154	14.29	No	Yes	3	8	7
104	R:R:R140	R:R:Y224	10.29	No	Yes	0	9	9
105	R:R:R140	R:R:Y323	8.23	No	Yes	0	9	9
106	R:R:V145	R:R:W141	7.36	No	No	0	7	8
107	R:R:F146	R:R:Y142	8.25	No	Yes	0	6	4
108	R:R:R149	R:R:Y142	5.14	No	Yes	3	5	4
109	R:R:R153	R:R:Y142	8.23	Yes	Yes	3	4	4
110	R:R:R154	R:R:V143	6.54	Yes	No	3	7	8
111	R:R:M227	R:R:T144	9.03	No	No	0	9	8
112	R:R:F146	R:R:V145	10.49	No	No	0	6	7
113	R:R:H230	R:R:V145	8.3	No	No	0	5	7
114	R:R:R149	R:R:R153	9.6	No	Yes	3	5	4
115	R:R:P156	R:R:T155	3.5	No	No	0	1	7
116	R:R:R157	R:R:T155	5.17	No	No	0	4	7
117	R:R:L160	R:R:L164	4.15	No	No	0	3	4
118	R:R:V173	R:R:Y207	3.79	No	No	4	5	4
119	R:R:H181	R:R:L180	11.57	Yes	No	0	5	4
120	R:R:F195	R:R:L180	13.4	Yes	No	2	6	4
121	R:R:F204	R:R:L180	7.31	Yes	No	2	5	4
122	R:R:E193	R:R:H181	11.08	No	Yes	0	4	5
123	L:L:R219	R:R:H181	3.39	Yes	Yes	0	0	5
124	R:R:A194	R:R:R182	8.3	No	No	0	3	5
125	R:R:A189	R:R:L183	4.73	No	No	0	4	3
126	R:R:S184	R:R:Y190	5.09	No	No	0	3	4
127	R:R:G186	R:R:P187	4.06	No	No	0	1	1
128	R:R:E193	R:R:F195	4.66	No	Yes	0	4	6
129	R:R:E193	R:R:Q286	3.82	No	No	0	4	4
130	R:R:F195	R:R:P196	4.33	Yes	No	0	6	4
131	R:R:E201	R:R:F195	19.82	No	Yes	0	4	6
132	R:R:F195	R:R:F204	6.43	Yes	Yes	2	6	5
133	R:R:L200	R:R:P196	4.93	No	No	0	3	4
134	R:R:A199	R:R:R202	4.15	No	No	0	1	1
135	L:L:R219	R:R:F204	7.48	Yes	Yes	2	0	5
136	R:R:L206	R:R:L210	4.15	No	No	0	5	5
137	R:R:A211	R:R:Y207	5.34	No	No	0	4	4
138	R:R:L212	R:R:N208	8.24	Yes	Yes	0	6	5
139	R:R:L283	R:R:N208	4.12	No	Yes	2	5	5
140	L:L:F220	R:R:N208	7.25	Yes	Yes	2	0	5
141	R:R:L209	R:R:Y213	3.52	No	Yes	7	5	8
142	R:R:L209	R:R:Q280	6.65	No	No	7	5	7
143	R:R:L210	R:R:L214	4.15	No	No	0	5	4
144	R:R:L210	R:R:L215	4.15	No	No	0	5	6
145	R:R:L214	R:R:Y213	3.52	No	Yes	0	4	8
146	R:R:G277	R:R:Y213	4.35	No	Yes	0	6	8
147	R:R:Q280	R:R:Y213	9.02	No	Yes	7	7	8
148	R:R:F272	R:R:L217	3.65	Yes	No	0	9	6
149	R:R:T220	R:R:Y224	4.99	No	Yes	6	8	9
150	R:R:C221	R:R:V269	3.42	No	No	0	5	8
151	R:R:M227	R:R:Y224	3.59	No	Yes	0	9	9
152	R:R:V265	R:R:Y224	20.19	No	Yes	0	8	9
153	R:R:L228	R:R:S262	4.5	No	No	0	5	7
154	R:R:L228	R:R:V265	4.47	No	No	0	5	8
155	R:R:H230	R:R:V234	4.15	No	No	0	5	6
156	R:R:L231	R:R:V261	4.47	No	No	0	8	8
157	R:R:Q246	R:R:S243	4.33	No	No	0	4	4
158	R:R:L245	R:R:Q248	6.65	No	No	0	3	4
159	R:R:L322	R:R:V268	5.96	Yes	No	5	8	8
160	R:R:V268	R:R:Y323	7.57	No	Yes	5	8	9
161	R:R:L271	R:R:L318	5.54	No	No	0	7	6
162	R:R:F272	R:R:W276	8.02	Yes	Yes	0	9	8
163	R:R:C275	R:R:N315	7.87	No	No	0	9	9
164	R:R:S312	R:R:W276	8.65	No	Yes	1	7	8
165	R:R:N315	R:R:W276	13.56	No	Yes	0	9	8
166	R:R:G277	R:R:P278	4.06	No	No	0	6	9
167	R:R:P278	R:R:W307	8.11	No	No	0	9	5
168	L:L:F220	R:R:I279	5.02	Yes	No	0	0	7
169	R:R:L281	R:R:L285	6.92	No	No	0	6	6
170	R:R:F282	R:R:Q286	3.51	No	No	0	5	4
171	R:R:F282	R:R:L304	4.87	No	No	0	5	6
172	R:R:F282	R:R:K305	18.61	No	No	0	5	4
173	L:L:R219	R:R:L283	7.29	Yes	No	2	0	5
174	L:L:F220	R:R:L283	3.65	Yes	No	2	0	5
175	R:R:L285	R:R:W294	9.11	No	No	0	6	1
176	R:R:G289	R:R:P290	4.06	No	No	0	3	1
177	R:R:P290	R:R:P296	7.79	No	No	0	1	3
178	R:R:P296	R:R:W294	4.05	No	No	0	3	1
179	R:R:H295	R:R:P296	7.63	No	No	0	3	3
180	R:R:H295	R:R:R297	5.64	No	No	0	3	2
181	R:R:H295	R:R:S298	4.18	No	No	0	3	4
182	L:L:W213	R:R:R297	12	No	No	0	0	2
183	L:L:F216	R:R:R297	9.62	No	No	0	0	2
184	R:R:Y299	R:R:Y302	5.96	No	Yes	8	4	5
185	L:L:Y211	R:R:Y299	13.9	No	No	8	0	4
186	R:R:T306	R:R:Y302	6.24	No	Yes	0	4	5
187	L:L:Y211	R:R:Y302	11.91	No	Yes	8	0	5
188	L:L:S215	R:R:Y302	6.36	No	Yes	0	0	5
189	L:L:F216	R:R:Y302	5.16	No	Yes	0	0	5
190	R:R:H309	R:R:K305	11.79	No	No	0	6	4
191	R:R:M311	R:R:W307	5.82	No	No	0	7	5
192	R:R:H309	R:R:Y313	11.98	No	Yes	1	6	7
193	R:R:L318	R:R:S314	4.5	No	No	0	6	5
194	R:R:N315	R:R:N319	10.9	No	No	0	9	9
195	R:R:N319	R:R:Y323	3.49	No	Yes	0	9	9
196	R:R:L321	R:R:L326	4.15	No	No	0	7	7
197	R:R:L322	R:R:Y323	8.21	Yes	Yes	5	8	9
198	R:R:A324	R:R:F330	9.71	No	Yes	0	7	8
199	R:R:F325	R:R:F330	5.36	No	Yes	0	6	8
200	R:R:H329	R:R:Q332	3.71	No	No	0	6	5
201	L:L:N212	L:L:N214	5.45	No	No	0	0	0
202	L:L:N212	L:L:S215	8.94	No	No	0	0	0
203	L:L:F220	L:L:R219	5.34	Yes	Yes	2	0	0
204	R:R:A219	R:R:T134	3.36	No	No	0	6	7
205	R:R:C68	R:R:I64	3.27	No	No	0	4	7
206	R:R:S184	R:R:S192	3.26	No	No	0	3	4
207	R:R:A308	R:R:I279	3.25	No	No	0	6	7
208	R:R:A333	R:R:M73	3.22	No	No	0	6	7
209	R:R:R335	R:R:R336	3.2	No	No	0	4	5
210	R:R:C130	R:R:L212	3.17	No	Yes	0	7	6
211	R:R:T220	R:R:V269	3.17	No	No	0	8	8
212	R:R:C275	R:R:L271	3.17	No	No	0	9	7
213	R:R:C115	R:R:N119	3.15	No	No	0	9	5
214	R:R:A317	R:R:L318	3.15	No	No	0	7	6
215	R:R:T129	R:R:T87	3.14	No	Yes	0	9	8
216	R:R:R154	R:R:Y142	3.09	Yes	Yes	3	7	4
217	R:R:F272	R:R:Y213	3.09	Yes	Yes	0	9	8
218	R:R:A256	R:R:E252	3.02	No	No	0	5	3
219	R:R:L200	R:R:S197	3	No	No	0	3	3
220	R:R:L44	R:R:V45	2.98	No	Yes	0	5	5
221	R:R:L62	R:R:V58	2.98	No	No	0	6	4
222	R:R:L93	R:R:V89	2.98	No	No	0	5	7
223	R:R:L110	R:R:V109	2.98	No	No	0	7	3
224	R:R:L228	R:R:V261	2.98	No	No	0	5	8
225	R:R:L288	R:R:V284	2.98	No	No	0	4	5
226	R:R:I67	R:R:I81	2.94	Yes	No	0	7	8
227	L:L:W213	R:R:Y190	2.89	No	No	0	0	4
228	R:R:F272	R:R:P216	2.89	Yes	No	0	9	9
229	R:R:G111	R:R:W108	2.81	No	No	0	8	8
230	R:R:C310	R:R:F49	2.79	No	Yes	0	5	7
231	R:R:P46	R:R:Y103	2.78	No	No	0	6	5
232	R:R:A150	R:R:R154	2.77	No	Yes	0	6	7
233	R:R:L322	R:R:L326	2.77	Yes	No	0	8	7
234	R:R:A273	R:R:Y213	2.67	No	Yes	0	5	8
235	R:R:F79	R:R:S163	2.64	No	No	0	6	8
236	R:R:R331	R:R:S328	2.64	No	No	0	8	5
237	R:R:R253	R:R:V257	2.62	No	No	0	3	6
238	R:R:A226	R:R:W141	2.59	No	No	0	5	8
239	R:R:A301	R:R:W294	2.59	No	No	0	6	1
240	R:R:F117	R:R:M114	2.49	No	No	0	5	6
241	R:R:L158	R:R:R153	2.43	No	Yes	0	4	4
242	R:R:L52	R:R:Y313	2.34	No	Yes	0	7	7
243	R:R:L105	R:R:Y103	2.34	No	No	0	4	5
244	R:R:Q332	R:R:R336	2.34	No	No	0	5	5
245	R:R:G186	R:R:P185	2.03	No	No	0	1	2
246	R:R:A172	R:R:G169	1.95	No	No	0	4	4
247	R:R:A254	R:R:G255	1.95	No	No	0	3	3
248	R:R:A175	R:R:P176	1.87	No	No	0	5	6
249	R:R:G169	R:R:V168	1.84	No	No	0	4	5
250	R:R:A205	R:R:A287	1.79	No	No	0	5	5
251	R:R:P185	R:R:S184	1.78	No	No	0	2	3
252	R:R:C223	R:R:S137	1.72	No	No	0	7	9
253	R:R:G56	R:R:L55	1.71	No	No	0	8	6
254	R:R:G56	R:R:L92	1.71	No	No	0	8	7
255	R:R:C223	R:R:V138	1.71	No	No	0	7	7
256	R:R:A199	R:R:S197	1.71	No	No	0	1	3
257	R:R:G247	R:R:L250	1.71	No	No	0	4	3
258	R:R:A300	R:R:S298	1.71	No	No	0	3	4
259	R:R:A135	R:R:V162	1.7	No	No	0	7	5
260	R:R:C95	R:R:T99	1.69	No	No	0	7	6
261	R:R:A100	R:R:T99	1.68	No	No	0	7	6
262	R:R:L105	R:R:P106	1.64	No	No	0	4	5
263	R:R:L183	R:R:P185	1.64	No	No	0	3	2
264	R:R:A82	R:R:I64	1.62	No	No	0	6	7
265	R:R:V257	R:R:V261	1.6	No	No	0	6	8
266	R:R:T90	R:R:V89	1.59	No	No	0	6	7
267	R:R:A42	R:R:L44	1.58	No	No	0	4	5
268	R:R:A244	R:R:L245	1.58	No	No	0	4	3
269	R:R:A254	R:R:L250	1.58	No	No	0	3	3
270	R:R:A267	R:R:L322	1.58	No	Yes	0	6	8
271	R:R:A287	R:R:L288	1.58	No	No	0	5	4
272	R:R:A333	R:R:Q332	1.52	No	No	0	6	5
273	R:R:A287	R:R:E201	1.51	No	No	0	5	4
274	R:R:G107	R:R:R188	1.5	No	No	0	5	2
275	R:R:G232	R:R:R258	1.5	No	No	0	5	7
276	R:R:G255	R:R:R258	1.5	No	No	0	3	7
277	R:R:G327	R:R:R331	1.5	No	No	0	8	8
278	R:R:L57	R:R:V89	1.49	No	No	0	6	7
279	R:R:F146	R:R:P147	1.44	No	No	0	6	8
280	R:R:Q248	R:R:V249	1.43	No	No	0	4	2
281	R:R:L148	R:R:L151	1.38	No	No	0	6	4
282	R:R:P46	R:R:W43	1.35	No	No	0	6	2
283	R:R:A171	R:R:Y120	1.33	No	Yes	0	4	6
284	R:R:R263	R:R:S262	1.32	No	No	0	7	7
285	R:R:H152	R:R:L151	1.29	No	No	0	5	4
286	R:R:D112	R:R:R182	1.19	No	No	0	3	5
287	R:R:E201	R:R:R198	1.16	No	No	0	4	1
288	R:R:L47	R:R:W43	1.14	No	No	0	6	2
289	R:R:H152	R:R:R153	1.13	No	Yes	0	5	4
290	R:R:H230	R:R:R233	1.13	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V45	4.4275	4	1	5
2	R:R:F49	5.294	5	1	7
3	R:R:I67	4.31	4	0	7
4	R:R:T87	5.45	4	0	8
5	R:R:F91	5.264	5	1	7
6	R:R:F98	8.84333	6	1	6
7	R:R:Y120	5.84	4	2	6
8	R:R:Q123	5.198	5	2	4
9	R:R:Q127	8.185	4	4	6
10	R:R:Y142	6.1775	4	3	4
11	R:R:R153	5.3475	4	3	4
12	R:R:R154	7.92333	6	3	7
13	R:R:H181	13.525	4	0	5
14	R:R:F195	9.728	5	2	6
15	R:R:F204	6.1825	4	2	5
16	R:R:N208	5.8925	4	2	5
17	R:R:L212	6.3	4	0	6
18	R:R:Y213	4.36167	6	7	8
19	R:R:Y224	10.102	5	6	9
20	R:R:F272	4.26	5	0	9
21	R:R:W276	8.764	5	1	8
22	R:R:Y302	7.126	5	8	5
23	R:R:Y313	7.775	6	1	7
24	R:R:L322	4.63	4	5	8
25	R:R:Y323	6.36333	6	5	9
26	R:R:F330	6.126	5	0	8
27	L:L:R219	6.102	5	2	0
28	L:L:F220	6.874	5	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:P46	R:R:V45	13.2347	3.53	No	Yes	0	6	5
2	R:R:F49	R:R:V45	15.9764	5.24	Yes	Yes	1	7	5
3	R:R:F49	R:R:Y313	14.3287	9.28	Yes	Yes	1	7	7
4	R:R:F91	R:R:Y313	73.9248	4.13	Yes	Yes	1	7	7
5	R:R:F91	R:R:S316	50.0819	6.61	Yes	No	0	7	9
6	R:R:F91	R:R:W276	100	5.01	Yes	Yes	1	7	8
7	R:R:F272	R:R:W276	72.0999	8.02	Yes	Yes	0	9	8
8	R:R:F272	R:R:L133	62.9136	3.65	Yes	No	0	9	8
9	R:R:L133	R:R:Y323	62.3245	4.69	No	Yes	0	8	9
10	R:R:M136	R:R:Y323	83.7711	5.99	No	Yes	0	9	9
11	R:R:L84	R:R:M136	82.1101	5.65	No	No	0	9	9
12	R:R:L84	R:R:T132	80.4314	4.42	No	No	0	9	8
13	R:R:T132	R:R:T87	78.7439	9.42	No	Yes	0	8	8
14	R:R:T87	R:R:W167	14.2269	4.85	Yes	No	0	8	9
15	R:R:T90	R:R:W167	10.2051	8.49	No	No	0	6	9
16	R:R:N315	R:R:W276	62.9756	13.56	No	Yes	0	9	8
17	R:R:N315	R:R:N319	59.441	10.9	No	No	0	9	9
18	R:R:N319	R:R:Y323	58.9007	3.49	No	Yes	0	9	9
19	R:R:D88	R:R:S316	44.0138	8.83	No	No	0	9	9
20	R:R:D88	R:R:N60	42.7736	12.12	No	No	0	9	9
21	R:R:A85	R:R:N60	38.9999	4.69	No	No	0	9	9
22	R:R:F330	R:R:V66	11.8661	5.24	Yes	No	0	8	7
23	R:R:F330	R:R:V63	36.4397	6.55	Yes	No	0	8	9
24	R:R:A85	R:R:V63	37.7242	3.39	No	No	0	9	9
25	R:R:F330	R:R:I67	21.7877	3.77	Yes	Yes	0	8	7
26	R:R:I67	R:R:N78	14.7451	5.66	Yes	No	0	7	8
27	R:R:M73	R:R:N78	11.8661	9.82	No	No	0	7	8
28	R:R:N83	R:R:T87	63.1572	4.39	No	Yes	0	9	8
29	R:R:N83	R:R:S163	61.3811	10.43	No	No	0	9	8
30	R:R:F79	R:R:S163	59.5961	2.64	No	No	0	6	8
31	R:R:A159	R:R:F79	54.1879	5.55	No	No	0	7	6
32	R:R:A159	R:R:Y80	52.3675	4	No	No	0	7	7
33	R:R:D139	R:R:Y80	46.8397	10.34	No	No	0	8	7
34	R:R:D139	R:R:R154	43.0217	14.29	No	Yes	3	8	7
35	L:L:L218	R:R:F98	29.1048	4.87	No	Yes	0	0	6
36	R:R:F98	R:R:L101	50.2237	8.53	Yes	No	0	6	4
37	L:L:N214	R:R:L101	47.7344	6.87	No	No	0	0	4
38	L:L:L218	R:R:N119	25.6633	6.87	No	No	0	0	5
39	R:R:C115	R:R:N119	18.634	3.15	No	No	0	9	5
40	R:R:C115	R:R:W108	14.0276	3.92	No	No	0	9	8
41	R:R:P185	R:R:S184	13.6289	1.78	No	No	0	2	3
42	R:R:S184	R:R:Y190	16.5611	5.09	No	No	0	3	4
43	L:L:W213	R:R:Y190	18.0139	2.89	No	No	0	0	4
44	L:L:W213	R:R:R297	19.4579	12	No	No	0	0	2
45	L:L:F216	R:R:R297	34.7566	9.62	No	No	0	0	2
46	L:L:F216	R:R:Y302	36.0943	5.16	No	Yes	0	0	5
47	L:L:S215	R:R:Y302	41.3562	6.36	No	Yes	0	0	5
48	L:L:N212	L:L:S215	42.6496	8.94	No	No	0	0	0
49	L:L:N212	L:L:N214	43.9341	5.45	No	No	0	0	0
50	R:R:H181	R:R:N119	24.2681	28.06	Yes	No	0	5	5
51	L:L:R219	R:R:H181	18.2088	3.39	Yes	Yes	0	0	5
52	L:L:R219	R:R:Q123	11.6446	7.01	Yes	Yes	2	0	4
53	R:R:Q123	R:R:S174	20.326	5.78	Yes	No	2	4	7
54	R:R:S174	R:R:Y120	10.1741	3.82	No	Yes	2	7	6
55	L:L:R219	R:R:F204	13.465	7.48	Yes	Yes	2	0	5
56	R:R:V126	R:R:W276	63.8437	8.58	No	Yes	0	7	8
57	R:R:L212	R:R:V126	19.1522	4.47	Yes	No	0	6	7
58	R:R:L212	R:R:N208	11.8173	8.24	Yes	Yes	0	6	5
59	L:L:F220	R:R:V126	45.3603	13.11	Yes	No	0	0	7
60	R:R:L212	R:R:Q127	10.2272	9.32	Yes	Yes	0	6	6
61	R:R:R140	R:R:Y323	35.5805	8.23	No	Yes	0	9	9
62	R:R:R140	R:R:Y224	33.8043	10.29	No	Yes	0	9	9
63	R:R:R154	R:R:Y142	29.818	3.09	Yes	Yes	3	7	4
64	R:R:F146	R:R:Y142	16.0783	8.25	No	Yes	0	6	4
65	R:R:F146	R:R:V145	12.0742	10.49	No	No	0	6	7
66	R:R:R153	R:R:Y142	10.1785	8.23	Yes	Yes	3	4	4
67	R:R:E201	R:R:F195	10.9182	19.82	No	Yes	0	4	6
68	R:R:F272	R:R:Y213	14.2933	3.09	Yes	Yes	0	9	8
69	R:R:V265	R:R:Y224	16.2245	20.19	No	Yes	0	8	9
70	R:R:L228	R:R:V265	14.2224	4.47	No	No	0	5	8
71	R:R:H295	R:R:R297	15.0994	5.64	No	No	0	3	2
72	R:R:H295	R:R:P296	10.6613	7.63	No	No	0	3	3
73	R:R:F98	R:R:Y313	51.6942	4.13	Yes	Yes	1	6	7
74	L:L:F220	L:L:R219	33.9859	5.34	Yes	Yes	2	0	0
75	R:R:N208	R:R:Q123	17.1192	3.96	Yes	Yes	2	5	4
76	R:R:F195	R:R:F204	12.5836	6.43	Yes	Yes	2	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F49	R:R:F98	4.29	1	Yes	Yes	7	6	2	1
R:R:F49	R:R:L102	4.87	1	Yes	No	7	5	2	2
R:R:F49	R:R:Y313	9.28	1	Yes	Yes	7	7	2	2
R:R:P97	R:R:V118	5.3	0	No	No	9	5	2	1
R:R:F98	R:R:L101	8.53	1	Yes	No	6	4	1	1
R:R:F98	R:R:L102	9.74	1	Yes	No	6	5	1	2
R:R:F98	R:R:H309	21.5	1	Yes	No	6	6	1	2
R:R:F98	R:R:Y313	4.13	1	Yes	Yes	6	7	1	2
L:L:L218	R:R:F98	4.87	0	No	Yes	0	6	0	1
L:L:N214	R:R:L101	6.87	0	No	No	0	4	0	1
L:L:G217	R:R:L101	3.42	0	No	No	0	4	0	1
L:L:N214	R:R:G107	5.09	0	No	No	0	5	0	1
L:L:L218	R:R:V118	7.45	0	No	No	0	5	0	1
R:R:H181	R:R:N119	28.06	0	Yes	No	5	5	1	1
L:L:L218	R:R:N119	6.87	0	No	No	0	5	0	1
R:R:Q123	R:R:S174	5.78	2	Yes	No	4	7	1	2
R:R:Q123	R:R:V177	5.73	2	Yes	No	4	5	1	2
R:R:F204	R:R:Q123	3.51	2	Yes	Yes	5	4	1	1
R:R:N208	R:R:Q123	3.96	2	Yes	Yes	5	4	1	1
L:L:R219	R:R:Q123	7.01	2	Yes	Yes	0	4	0	1
R:R:L212	R:R:V126	4.47	0	Yes	No	6	7	2	1
R:R:V126	R:R:W276	8.58	0	No	Yes	7	8	1	2
L:L:F220	R:R:V126	13.11	2	Yes	No	0	7	0	1
R:R:H181	R:R:L180	11.57	0	Yes	No	5	4	1	2
R:R:F195	R:R:L180	13.4	2	Yes	No	6	4	2	2
R:R:F204	R:R:L180	7.31	2	Yes	No	5	4	1	2
R:R:E193	R:R:H181	11.08	0	No	Yes	4	5	2	1
L:L:R219	R:R:H181	3.39	2	Yes	Yes	0	5	0	1
R:R:S184	R:R:Y190	5.09	0	No	No	3	4	2	1
R:R:E193	R:R:F195	4.66	0	No	Yes	4	6	2	2
R:R:F195	R:R:F204	6.43	2	Yes	Yes	6	5	2	1
L:L:R219	R:R:F204	7.48	2	Yes	Yes	0	5	0	1
R:R:L212	R:R:N208	8.24	0	Yes	Yes	6	5	2	1
R:R:L283	R:R:N208	4.12	2	No	Yes	5	5	1	1
L:L:F220	R:R:N208	7.25	2	Yes	Yes	0	5	0	1
L:L:F220	R:R:I279	5.02	2	Yes	No	0	7	0	1
L:L:R219	R:R:L283	7.29	2	Yes	No	0	5	0	1
L:L:F220	R:R:L283	3.65	2	Yes	No	0	5	0	1
R:R:H295	R:R:R297	5.64	0	No	No	3	2	2	1
L:L:W213	R:R:R297	12	0	No	No	0	2	0	1
L:L:F216	R:R:R297	9.62	0	No	No	0	2	0	1
R:R:Y299	R:R:Y302	5.96	8	No	Yes	4	5	1	1
L:L:Y211	R:R:Y299	13.9	8	No	No	0	4	0	1
R:R:T306	R:R:Y302	6.24	0	No	Yes	4	5	2	1
L:L:Y211	R:R:Y302	11.91	8	No	Yes	0	5	0	1
L:L:S215	R:R:Y302	6.36	0	No	Yes	0	5	0	1
L:L:F216	R:R:Y302	5.16	0	No	Yes	0	5	0	1
R:R:H309	R:R:Y313	11.98	1	No	Yes	6	7	2	2
R:R:A308	R:R:I279	3.25	0	No	No	6	7	2	1
R:R:C115	R:R:N119	3.15	0	No	No	9	5	2	1
L:L:W213	R:R:Y190	2.89	0	No	No	0	4	0	1
R:R:G107	R:R:R188	1.5	0	No	No	5	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZJD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.39
Number of Linked Nodes	273
Number of Links	290
Number of Hubs	28
Number of Links mediated by Hubs	111
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	55

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	50792
Length Of Smallest Path	3
Average Path Length	15.5989
Length of Longest Path	38
Minimum Path Strength	1.21
Average Path Strength	6.78426
Maximum Path Strength	22.58
Minimum Path Correlation	0.7
Average Path Correlation	0.937302
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	52.5528
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	36.7608
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • glutamate receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to abiotic stimulus • response to radiation • phototransduction, visible light • cell activation • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • cellular response to chemical stimulus • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • cytosolic region • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • ciliary basal body • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • signaling receptor binding • kisspeptin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • cellular component organization • organelle organization • cellular component organization or biogenesis • cytoskeleton organization • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • neuropeptide signaling pathway • cell surface
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969F8
Sequence	>8ZJD_nogp_Chain_R A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H K P M R T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y P L P G W V L G D F M C K F V N Y I Q Q V S V Q A T C W T L T A M S V D R W Y V T V F P L R A L H R R T P R L A L A V S L S I W V G S A A V S A P V L A L H R L S P G P R A Y C S E A F P S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G P W H P R S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R Q A F R R V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZJD	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-	chim(NtGi1-Gq)/β1/γ1	3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJD (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-		3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-	chim(NtGi1-Gq)/β1/γ1	3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-		3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8XGO	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ2	2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-	chim(NtGi1-Gq)/β1/γ2	2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-		2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	Gi1/β1/γ2	3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3	2024-10-30	doi.org/10.1126/sciadv.adn7771

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