psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L44	R:R:V40	2.98	No	No	0	5	4
2	R:R:D41	R:R:Y302	11.49	No	Yes	0	2	5
3	R:R:P46	R:R:V45	3.53	No	No	0	6	5
4	R:R:F49	R:R:V45	7.87	Yes	No	0	7	5
5	R:R:V45	R:R:Y103	7.57	No	Yes	0	5	5
6	R:R:F48	R:R:L47	4.87	No	No	0	4	6
7	R:R:F49	R:R:V96	2.62	Yes	Yes	1	7	8
8	R:R:F49	R:R:T99	2.59	Yes	Yes	1	7	6
9	R:R:A100	R:R:F49	4.16	No	Yes	0	7	7
10	R:R:F49	R:R:Y313	7.22	Yes	Yes	1	7	7
11	R:R:L57	R:R:M53	7.07	No	Yes	0	6	7
12	R:R:L92	R:R:M53	5.65	Yes	Yes	1	7	7
13	R:R:L93	R:R:M53	4.24	No	Yes	0	5	7
14	R:R:M53	R:R:V96	10.65	Yes	Yes	1	7	8
15	R:R:L54	R:R:V58	2.98	No	No	0	6	4
16	R:R:A85	R:R:N60	3.13	No	Yes	0	9	9
17	R:R:D88	R:R:N60	6.73	Yes	Yes	0	9	9
18	R:R:N60	R:R:V89	2.96	Yes	No	0	9	7
19	R:R:N60	R:R:P320	11.4	Yes	No	0	9	9
20	R:R:A85	R:R:I64	3.25	No	No	0	9	7
21	R:R:R69	R:R:Y65	9.26	No	No	0	5	4
22	R:R:F330	R:R:V66	9.18	Yes	No	0	8	7
23	R:R:F334	R:R:V66	5.24	No	No	0	6	7
24	R:R:I67	R:R:N78	7.08	No	No	0	7	8
25	R:R:F330	R:R:I67	3.77	Yes	No	0	8	7
26	R:R:R336	R:R:R69	4.26	No	No	0	5	5
27	R:R:H70	R:R:P72	18.3	No	No	0	5	5
28	R:R:H70	R:R:M73	7.88	No	Yes	0	5	7
29	R:R:K71	R:R:R74	2.48	No	No	0	6	7
30	R:R:M73	R:R:N78	9.82	Yes	No	0	7	8
31	R:R:H329	R:R:M73	7.88	No	Yes	0	6	7
32	R:R:A333	R:R:M73	3.22	No	Yes	0	6	7
33	R:R:T75	R:R:V76	3.17	No	Yes	0	7	6
34	R:R:T75	R:R:T77	3.14	No	No	0	7	8
35	R:R:N78	R:R:T75	4.39	No	No	0	8	7
36	R:R:V76	R:R:Y80	3.79	Yes	No	0	6	7
37	R:R:R154	R:R:V76	9.15	Yes	Yes	0	7	6
38	R:R:F79	R:R:N83	6.04	No	No	0	6	9
39	R:R:A159	R:R:F79	4.16	No	No	0	7	6
40	R:R:F79	R:R:L160	6.09	No	No	0	6	3
41	R:R:D139	R:R:Y80	11.49	No	No	0	8	7
42	R:R:A159	R:R:Y80	5.34	No	No	0	7	7
43	R:R:N83	R:R:S163	8.94	No	No	0	9	8
44	R:R:D88	R:R:L84	2.71	Yes	Yes	1	9	9
45	R:R:L84	R:R:T132	7.37	Yes	No	0	9	8
46	R:R:L84	R:R:M136	2.83	Yes	No	1	9	9
47	R:R:L84	R:R:N319	6.87	Yes	Yes	1	9	9
48	R:R:L84	R:R:Y323	5.86	Yes	Yes	1	9	9
49	R:R:T129	R:R:T87	3.14	No	No	0	9	8
50	R:R:T132	R:R:T87	9.42	No	No	0	8	8
51	R:R:D88	R:R:S316	10.31	Yes	No	1	9	9
52	R:R:D88	R:R:N319	6.73	Yes	Yes	1	9	9
53	R:R:L93	R:R:V89	2.98	No	No	0	5	7
54	R:R:F91	R:R:L92	3.65	Yes	Yes	1	7	7
55	R:R:C95	R:R:F91	6.98	No	Yes	1	7	7
56	R:R:F91	R:R:S125	7.93	Yes	No	1	7	8
57	R:R:F91	R:R:V126	2.62	Yes	Yes	1	7	7
58	R:R:F91	R:R:T129	2.59	Yes	No	0	7	9
59	R:R:F91	R:R:Y313	4.13	Yes	Yes	1	7	7
60	R:R:F91	R:R:S316	3.96	Yes	No	1	7	9
61	R:R:L92	R:R:V96	2.98	Yes	Yes	1	7	8
62	R:R:L92	R:R:S316	9.01	Yes	No	1	7	9
63	R:R:C94	R:R:I121	8.18	No	No	0	4	5
64	R:R:C95	R:R:Q122	12.21	No	No	0	7	6
65	R:R:C95	R:R:Y313	6.72	No	Yes	1	7	7
66	R:R:P97	R:R:V96	5.3	No	Yes	0	9	8
67	R:R:V96	R:R:Y313	5.05	Yes	Yes	1	8	7
68	R:R:F98	R:R:V118	6.55	No	No	0	6	5
69	R:R:H309	R:R:T99	6.85	Yes	Yes	1	6	6
70	R:R:T99	R:R:Y313	3.75	Yes	Yes	1	6	7
71	L:L:?9	R:R:T99	10.94	Yes	Yes	1	0	6
72	R:R:L102	R:R:Y103	3.52	No	Yes	0	5	5
73	R:R:Y103	R:R:Y302	9.93	Yes	Yes	2	5	5
74	R:R:K305	R:R:Y103	7.17	No	Yes	0	4	5
75	R:R:T306	R:R:Y103	4.99	No	Yes	2	4	5
76	R:R:L105	R:R:P106	4.93	No	No	0	4	5
77	R:R:L110	R:R:W108	9.11	No	Yes	0	7	8
78	R:R:C115	R:R:W108	7.84	No	Yes	3	9	8
79	R:R:V118	R:R:W108	3.68	No	Yes	0	5	8
80	R:R:C191	R:R:W108	10.45	No	Yes	3	9	8
81	R:R:L110	R:R:M114	7.07	No	No	0	7	6
82	R:R:G111	R:R:M114	3.49	No	No	0	8	6
83	R:R:D112	R:R:K116	5.53	No	No	0	3	7
84	R:R:D112	R:R:L183	9.5	No	No	0	3	3
85	R:R:F113	R:R:M114	4.98	No	No	0	3	6
86	R:R:F113	R:R:F117	5.36	No	No	0	3	5
87	R:R:C115	R:R:N119	3.15	No	No	0	9	5
88	R:R:C115	R:R:C191	7.28	No	No	3	9	9
89	L:L:L6	R:R:V118	2.98	No	No	0	0	5
90	R:R:H181	R:R:N119	28.06	Yes	No	0	5	5
91	L:L:L6	R:R:N119	9.61	No	No	0	0	5
92	R:R:V124	R:R:Y120	3.79	Yes	Yes	0	5	6
93	R:R:A175	R:R:Y120	2.67	No	Yes	0	5	6
94	R:R:V177	R:R:Y120	3.79	No	Yes	0	5	6
95	R:R:L178	R:R:Y120	11.72	No	Yes	0	5	6
96	R:R:I121	R:R:Q122	2.74	No	No	0	5	6
97	L:L:?9	R:R:Q122	3.29	Yes	No	0	0	6
98	R:R:Q123	R:R:S174	2.89	No	No	0	4	7
99	L:L:R7	R:R:Q123	4.67	Yes	No	1	0	4
100	L:L:F8	R:R:Q123	7.03	Yes	No	1	0	4
101	R:R:V124	R:R:W167	2.45	Yes	Yes	0	5	9
102	R:R:S174	R:R:V124	4.85	No	Yes	0	7	5
103	R:R:S125	R:R:V126	3.23	No	Yes	1	8	7
104	R:R:L212	R:R:V126	4.47	No	Yes	0	6	7
105	R:R:V126	R:R:W276	2.45	Yes	Yes	1	7	8
106	L:L:F8	R:R:V126	5.24	Yes	Yes	1	0	7
107	R:R:Q127	R:R:S170	2.89	Yes	No	0	6	7
108	R:R:Q127	R:R:V173	2.87	Yes	No	0	6	5
109	R:R:L212	R:R:Q127	6.65	No	Yes	0	6	6
110	R:R:A128	R:R:W167	7.78	No	Yes	0	7	9
111	R:R:C130	R:R:P216	3.77	No	No	0	7	9
112	R:R:L133	R:R:T220	4.42	No	No	0	8	8
113	R:R:F272	R:R:L133	3.65	No	No	0	9	8
114	R:R:M136	R:R:R140	3.72	No	No	1	9	9
115	R:R:M136	R:R:Y323	11.97	No	Yes	1	9	9
116	R:R:S137	R:R:T220	6.4	No	No	1	9	8
117	R:R:C223	R:R:S137	5.16	No	No	0	7	9
118	R:R:S137	R:R:Y224	15.26	No	Yes	1	9	9
119	R:R:C223	R:R:V138	3.42	No	No	0	7	7
120	R:R:D139	R:R:R154	11.91	No	Yes	0	8	7
121	R:R:R140	R:R:Y224	13.38	No	Yes	1	9	9
122	R:R:R140	R:R:Y323	5.14	No	Yes	1	9	9
123	R:R:V145	R:R:W141	11.03	No	No	0	7	8
124	R:R:C223	R:R:W141	2.61	No	No	0	7	8
125	R:R:A226	R:R:W141	3.89	No	No	0	5	8
126	R:R:R149	R:R:Y142	3.09	No	No	0	5	4
127	R:R:A150	R:R:Y142	2.67	No	No	0	6	4
128	R:R:R154	R:R:Y142	4.12	Yes	No	0	7	4
129	R:R:R154	R:R:V143	3.92	Yes	No	0	7	8
130	R:R:M227	R:R:T144	12.04	No	No	0	9	8
131	R:R:F146	R:R:V145	10.49	No	No	0	6	7
132	R:R:H230	R:R:V145	2.77	No	No	0	5	7
133	R:R:R149	R:R:R153	7.46	No	No	0	5	4
134	R:R:P156	R:R:T155	3.5	No	No	0	1	7
135	R:R:R157	R:R:T155	6.47	No	No	0	4	7
136	R:R:I166	R:R:V162	3.07	Yes	No	0	7	5
137	R:R:S163	R:R:W167	2.47	No	Yes	0	8	9
138	R:R:V173	R:R:Y207	2.52	No	No	0	5	4
139	R:R:H181	R:R:V177	2.77	Yes	No	0	5	5
140	R:R:H181	R:R:L180	3.86	Yes	No	0	5	4
141	R:R:E193	R:R:L180	5.3	Yes	No	0	4	4
142	L:L:R7	R:R:H181	12.41	Yes	Yes	0	0	5
143	R:R:A194	R:R:R182	5.53	No	No	0	3	5
144	R:R:P185	R:R:S184	7.13	No	No	0	2	3
145	R:R:G186	R:R:P187	4.06	No	No	0	1	1
146	R:R:P187	R:R:R188	8.65	No	No	0	1	2
147	R:R:R188	R:R:Y190	3.09	No	No	0	2	4
148	L:L:N2	R:R:Y190	3.49	No	No	0	0	4
149	L:L:S3	R:R:Y190	7.63	No	No	0	0	4
150	R:R:E193	R:R:F195	5.83	Yes	No	4	4	6
151	R:R:E193	R:R:E201	17.76	Yes	No	4	4	4
152	R:R:E201	R:R:F195	3.5	No	No	4	4	6
153	R:R:L200	R:R:P196	11.49	No	No	0	3	4
154	R:R:R198	R:R:R202	12.79	No	No	0	1	1
155	R:R:L288	R:R:R202	9.72	No	No	0	4	1
156	R:R:F204	R:R:N208	4.83	No	No	0	5	5
157	L:L:R7	R:R:F204	8.55	Yes	No	0	0	5
158	R:R:L206	R:R:L210	2.77	No	No	0	5	5
159	R:R:L209	R:R:Q280	2.66	No	Yes	0	5	7
160	R:R:L210	R:R:L214	4.15	No	No	5	5	4
161	R:R:L212	R:R:Q280	2.66	No	Yes	0	6	7
162	R:R:L217	R:R:Y213	5.86	No	Yes	0	6	8
163	R:R:W276	R:R:Y213	5.79	Yes	Yes	1	8	8
164	R:R:G277	R:R:Y213	5.79	No	Yes	0	6	8
165	R:R:Q280	R:R:Y213	4.51	Yes	Yes	1	7	8
166	R:R:F272	R:R:L217	4.87	No	No	0	9	6
167	R:R:A273	R:R:L217	4.73	No	No	0	5	6
168	R:R:T220	R:R:Y224	2.5	No	Yes	1	8	9
169	R:R:V265	R:R:Y224	10.09	No	Yes	0	8	9
170	R:R:L228	R:R:V261	2.98	No	No	0	5	8
171	R:R:L228	R:R:S262	7.51	No	No	0	5	7
172	R:R:R229	R:R:R233	14.93	No	No	0	4	5
173	R:R:L231	R:R:R258	3.64	No	No	0	8	7
174	R:R:G232	R:R:R258	3	No	No	0	5	7
175	R:R:D242	R:R:S243	4.42	No	No	0	4	4
176	R:R:Q246	R:R:S243	5.78	No	No	0	4	4
177	R:R:V268	R:R:Y323	8.83	No	Yes	0	8	9
178	R:R:L271	R:R:L318	5.54	No	No	0	7	6
179	R:R:F272	R:R:W276	3.01	No	Yes	0	9	8
180	R:R:C275	R:R:N315	6.3	No	No	0	9	9
181	R:R:Q280	R:R:W276	4.38	Yes	Yes	1	7	8
182	R:R:S312	R:R:W276	8.65	No	Yes	0	7	8
183	R:R:N315	R:R:W276	7.91	No	Yes	0	9	8
184	R:R:G277	R:R:P278	4.06	No	No	0	6	9
185	R:R:P278	R:R:W307	5.4	No	No	0	9	5
186	R:R:I279	R:R:Q280	4.12	Yes	Yes	0	7	7
187	R:R:I279	R:R:L283	2.85	Yes	No	0	7	5
188	R:R:A308	R:R:I279	4.87	No	Yes	0	6	7
189	R:R:H309	R:R:I279	2.65	Yes	Yes	0	6	7
190	R:R:L281	R:R:L285	2.77	No	No	0	6	6
191	R:R:F282	R:R:L304	6.09	No	No	0	5	6
192	R:R:F282	R:R:K305	11.17	No	No	0	5	4
193	L:L:R7	R:R:L283	3.64	Yes	No	0	0	5
194	R:R:L285	R:R:W294	9.11	No	No	0	6	1
195	R:R:Q286	R:R:R297	4.67	No	No	0	4	2
196	R:R:G289	R:R:P290	4.06	No	No	0	3	1
197	R:R:A301	R:R:W294	5.19	No	No	0	6	1
198	R:R:H295	R:R:P296	9.15	No	No	0	3	3
199	R:R:H295	R:R:R297	3.39	No	No	0	3	2
200	R:R:H295	R:R:S298	2.79	No	No	0	3	4
201	L:L:F4	R:R:R297	19.24	Yes	No	0	0	2
202	L:L:W1	R:R:Y299	6.75	No	No	0	0	4
203	R:R:T306	R:R:Y302	6.24	No	Yes	2	4	5
204	R:R:H309	R:R:K305	13.1	Yes	No	0	6	4
205	R:R:M311	R:R:W307	10.47	No	No	0	7	5
206	R:R:H309	R:R:Y313	9.8	Yes	Yes	1	6	7
207	L:L:?9	R:R:H309	9.55	Yes	Yes	1	0	6
208	R:R:M311	R:R:S314	3.07	No	No	0	7	5
209	L:L:?9	R:R:Y313	2.9	Yes	Yes	1	0	7
210	R:R:N319	R:R:P320	3.26	Yes	No	0	9	9
211	R:R:N319	R:R:Y323	12.79	Yes	Yes	1	9	9
212	R:R:F325	R:R:L321	3.65	No	No	0	6	7
213	R:R:L322	R:R:L326	2.77	Yes	No	0	8	7
214	R:R:A324	R:R:F330	8.32	No	Yes	0	7	8
215	R:R:F325	R:R:F330	5.36	No	Yes	0	6	8
216	R:R:G327	R:R:R331	4.5	No	No	0	8	8
217	R:R:F334	R:R:V337	2.62	No	No	0	6	6
218	R:R:R336	R:R:V337	13.08	No	No	0	5	6
219	L:L:N2	L:L:W1	3.39	No	No	0	0	0
220	L:L:F4	L:L:N2	6.04	Yes	No	0	0	0
221	L:L:F8	L:L:R7	7.48	Yes	Yes	1	0	0
222	L:L:?9	L:L:F8	3.01	Yes	Yes	1	0	0
223	R:R:T90	R:R:W167	2.43	No	Yes	0	6	9
224	R:R:L158	R:R:R157	2.43	No	No	0	4	4
225	R:R:M227	R:R:Y224	2.39	No	Yes	0	9	9
226	R:R:L322	R:R:Y323	2.34	Yes	Yes	0	8	9
227	R:R:H152	R:R:R153	2.26	No	No	0	5	4
228	R:R:Y299	R:R:Y302	1.99	No	Yes	0	4	5
229	R:R:A317	R:R:G56	1.95	No	No	0	7	8
230	R:R:A189	R:R:G107	1.95	No	No	0	4	5
231	R:R:A172	R:R:G169	1.95	No	No	0	4	4
232	R:R:A235	R:R:G232	1.95	No	No	0	4	5
233	R:R:A254	R:R:G255	1.95	No	No	0	3	3
234	R:R:A42	R:R:P104	1.87	No	No	0	4	5
235	R:R:A175	R:R:P176	1.87	No	No	0	5	6
236	R:R:G292	R:R:S293	1.86	No	No	0	3	3
237	R:R:G59	R:R:V58	1.84	No	No	0	8	4
238	R:R:G169	R:R:V168	1.84	No	No	0	4	5
239	R:R:A205	R:R:A287	1.79	No	No	0	5	5
240	R:R:A235	R:R:A254	1.79	No	No	0	4	3
241	R:R:P320	R:R:V63	1.77	No	No	0	9	9
242	R:R:P156	R:R:V76	1.77	No	Yes	0	1	6
243	R:R:P216	R:R:T134	1.75	No	No	0	9	7
244	R:R:G56	R:R:L55	1.71	No	No	0	8	6
245	R:R:G56	R:R:L92	1.71	No	Yes	0	8	7
246	R:R:G107	R:R:L105	1.71	No	No	0	5	4
247	R:R:A199	R:R:S197	1.71	No	No	0	1	3
248	R:R:C221	R:R:V269	1.71	No	No	0	5	8
249	R:R:G247	R:R:L250	1.71	No	No	0	4	3
250	R:R:G289	R:R:L288	1.71	No	No	0	3	4
251	R:R:A171	R:R:V124	1.7	No	Yes	0	4	5
252	R:R:C130	R:R:T129	1.69	No	No	0	7	9
253	R:R:A219	R:R:T134	1.68	No	No	0	6	7
254	R:R:A303	R:R:T306	1.68	No	No	0	2	4
255	R:R:K71	R:R:P72	1.67	No	No	0	6	5
256	R:R:C68	R:R:I64	1.64	No	No	0	4	7
257	R:R:L215	R:R:P216	1.64	No	No	0	6	9
258	R:R:G247	R:R:Q248	1.64	No	No	0	4	4
259	R:R:A131	R:R:I166	1.62	No	Yes	0	6	7
260	R:R:A135	R:R:I166	1.62	No	Yes	0	7	7
261	R:R:C310	R:R:M311	1.62	No	No	0	5	7
262	R:R:V261	R:R:V265	1.6	No	No	0	8	8
263	R:R:V265	R:R:V269	1.6	No	No	0	8	8
264	R:R:C191	R:R:L183	1.59	No	No	0	9	3
265	R:R:A179	R:R:L180	1.58	No	No	0	4	4
266	R:R:A266	R:R:L270	1.58	No	No	0	5	5
267	R:R:A267	R:R:L322	1.58	No	Yes	0	6	8
268	R:R:E201	R:R:P196	1.57	No	No	0	4	4
269	R:R:A205	R:R:N208	1.56	No	No	0	5	5
270	R:R:A42	R:R:D41	1.54	No	No	0	4	2
271	R:R:I81	R:R:V63	1.54	No	No	0	8	9
272	R:R:A131	R:R:Q127	1.52	No	Yes	0	6	6
273	R:R:A211	R:R:Q127	1.52	No	Yes	0	4	6
274	R:R:I166	R:R:T132	1.52	Yes	No	0	7	8
275	L:L:F4	L:L:G5	1.51	Yes	No	0	0	0
276	R:R:L52	R:R:S314	1.5	No	No	0	7	5
277	R:R:L200	R:R:S197	1.5	No	No	0	3	3
278	R:R:L245	R:R:S243	1.5	No	No	0	3	4
279	R:R:L231	R:R:V257	1.49	No	No	0	8	6
280	R:R:F146	R:R:P147	1.44	No	No	0	6	8
281	R:R:E193	R:R:S192	1.44	Yes	No	0	4	4
282	R:R:Q332	R:R:S328	1.44	No	No	0	5	5
283	R:R:A301	R:R:F282	1.39	No	No	0	6	5
284	L:L:F4	R:R:A301	1.39	Yes	No	0	0	6
285	R:R:L44	R:R:L47	1.38	No	No	0	5	6
286	R:R:L101	R:R:L102	1.38	No	No	0	4	5
287	R:R:L148	R:R:L151	1.38	No	No	0	6	4
288	R:R:L210	R:R:L215	1.38	No	No	5	5	6
289	R:R:L214	R:R:L215	1.38	No	No	5	4	6
290	R:R:L264	R:R:L326	1.38	No	No	0	8	7
291	R:R:L271	R:R:L322	1.38	No	Yes	0	7	8
292	R:R:R258	R:R:S262	1.32	No	No	0	7	7
293	R:R:R331	R:R:S328	1.32	No	No	0	8	5
294	R:R:A189	R:R:W108	1.3	No	Yes	0	4	8
295	R:R:A300	R:R:W294	1.3	No	No	0	3	1
296	R:R:H152	R:R:L151	1.29	No	No	0	5	4
297	R:R:L44	R:R:W43	1.14	No	No	0	5	2

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F49	4.892	5	1	7
2	R:R:M53	6.9025	4	1	7
3	R:R:N60	6.055	4	0	9
4	R:R:M73	7.2	4	0	7
5	R:R:V76	4.47	4	0	6
6	R:R:L84	5.128	5	1	9
7	R:R:D88	6.62	4	1	9
8	R:R:F91	4.55143	7	1	7
9	R:R:L92	4.6	5	1	7
10	R:R:V96	5.32	5	1	8
11	R:R:T99	6.0325	4	1	6
12	R:R:Y103	6.636	5	2	5
13	R:R:W108	6.476	5	3	8
14	R:R:Y120	5.4925	4	0	6
15	R:R:V124	3.1975	4	0	5
16	R:R:V126	3.602	5	1	7
17	R:R:Q127	3.09	5	0	6
18	R:R:R154	7.275	4	0	7
19	R:R:I166	1.9575	4	0	7
20	R:R:W167	3.7825	4	0	9
21	R:R:H181	11.775	4	0	5
22	R:R:E193	7.5825	4	4	4
23	R:R:Y213	5.4875	4	1	8
24	R:R:Y224	8.724	5	1	9
25	R:R:W276	5.365	6	1	8
26	R:R:I279	3.6225	4	0	7
27	R:R:Q280	3.666	5	1	7
28	R:R:Y302	7.4125	4	2	5
29	R:R:H309	8.39	5	1	6
30	R:R:Y313	5.65286	7	1	7
31	R:R:N319	7.4125	4	1	9
32	R:R:L322	2.0175	4	0	8
33	R:R:Y323	7.82167	6	1	9
34	R:R:F330	6.6575	4	0	8
35	L:L:F4	7.045	4	0	0
36	L:L:R7	7.35	5	1	0
37	L:L:F8	5.69	4	1	0
38	L:L:?9	5.938	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Y103	R:R:Y302	19.3538	9.93	Yes	Yes	2	5	5
2	R:R:V45	R:R:Y103	11.2022	7.57	No	Yes	0	5	5
3	R:R:F49	R:R:V45	18.6649	7.87	Yes	No	0	7	5
4	R:R:K305	R:R:Y103	24.9877	7.17	No	Yes	0	4	5
5	R:R:H309	R:R:K305	71.1333	13.1	Yes	No	0	6	4
6	R:R:F49	R:R:Y313	14.1053	7.22	Yes	Yes	1	7	7
7	R:R:H309	R:R:Y313	19.3948	9.8	Yes	Yes	1	6	7
8	R:R:L92	R:R:V96	10.1279	2.98	Yes	Yes	1	7	8
9	R:R:D88	R:R:N60	19.526	6.73	Yes	Yes	0	9	9
10	R:R:D88	R:R:S316	69.4358	10.31	Yes	No	1	9	9
11	R:R:F91	R:R:S316	57.3725	3.96	Yes	No	1	7	9
12	R:R:F91	R:R:Y313	28.7846	4.13	Yes	Yes	1	7	7
13	R:R:L92	R:R:S316	12.9736	9.01	Yes	No	1	7	9
14	R:R:D88	R:R:N319	28.0056	6.73	Yes	Yes	1	9	9
15	L:L:?9	R:R:H309	29.6539	9.55	Yes	Yes	1	0	6
16	L:L:?9	L:L:F8	48.7617	3.01	Yes	Yes	1	0	0
17	L:L:F8	R:R:Q123	87.8219	7.03	Yes	No	1	0	4
18	R:R:Q123	R:R:S174	91.8238	2.89	No	No	0	4	7
19	R:R:S174	R:R:V124	90.5691	4.85	No	Yes	0	7	5
20	R:R:V124	R:R:W167	98.3024	2.45	Yes	Yes	0	5	9
21	R:R:S163	R:R:W167	94.0955	2.47	No	Yes	0	8	9
22	R:R:N83	R:R:S163	92.6603	8.94	No	No	0	9	8
23	R:R:F79	R:R:N83	91.2088	6.04	No	No	0	6	9
24	R:R:A159	R:R:F79	88.2565	4.16	No	No	0	7	6
25	R:R:A159	R:R:Y80	86.7558	5.34	No	No	0	7	7
26	R:R:V76	R:R:Y80	66.5081	3.79	Yes	No	0	6	7
27	R:R:T75	R:R:V76	42.5291	3.17	No	Yes	0	7	6
28	R:R:N78	R:R:T75	38.7896	4.39	No	No	0	8	7
29	R:R:I67	R:R:N78	23.1753	7.08	No	No	0	7	8
30	R:R:F330	R:R:I67	21.1497	3.77	Yes	No	0	8	7
31	R:R:F330	R:R:V66	12.8834	9.18	Yes	No	0	8	7
32	R:R:F334	R:R:V66	10.7758	5.24	No	No	0	6	7
33	R:R:M73	R:R:N78	14.9746	9.82	Yes	No	0	7	8
34	R:R:R154	R:R:V76	19.1734	9.15	Yes	Yes	0	7	6
35	R:R:D139	R:R:Y80	19.1488	11.49	No	No	0	8	7
36	R:R:D139	R:R:R154	17.3282	11.91	No	Yes	0	8	7
37	R:R:D88	R:R:L84	32.1388	2.71	Yes	Yes	1	9	9
38	R:R:F91	R:R:T129	21.7566	2.59	Yes	No	0	7	9
39	R:R:T129	R:R:T87	10.1689	3.14	No	No	0	9	8
40	R:R:L84	R:R:M136	13.154	2.83	Yes	No	1	9	9
41	R:R:L84	R:R:Y323	26.5704	5.86	Yes	Yes	1	9	9
42	R:R:N319	R:R:Y323	23.8314	12.79	Yes	Yes	1	9	9
43	R:R:F91	R:R:V126	65.196	2.62	Yes	Yes	1	7	7
44	L:L:F8	R:R:V126	100	5.24	Yes	Yes	1	0	7
45	R:R:H309	R:R:I279	30.1952	2.65	Yes	Yes	0	6	7
46	R:R:I279	R:R:L283	18.6075	2.85	Yes	No	0	7	5
47	L:L:R7	R:R:L283	18.4517	3.64	Yes	No	0	0	5
48	L:L:R7	R:R:H181	63.9905	12.41	Yes	Yes	0	0	5
49	R:R:H181	R:R:N119	46.1128	28.06	Yes	No	0	5	5
50	L:L:F8	L:L:R7	55.6995	7.48	Yes	Yes	1	0	0
51	R:R:C115	R:R:N119	36.5672	3.15	No	No	0	9	5
52	R:R:C115	R:R:W108	24.4464	7.84	No	Yes	3	9	8
53	R:R:A189	R:R:W108	10.1935	1.3	No	Yes	0	4	8
54	R:R:L110	R:R:W108	12.703	9.11	No	Yes	0	7	8
55	R:R:L110	R:R:M114	10.1935	7.07	No	No	0	7	6
56	R:R:H181	R:R:V177	24.1102	2.77	Yes	No	0	5	5
57	R:R:V177	R:R:Y120	22.5357	3.79	No	Yes	0	5	6
58	R:R:V124	R:R:Y120	21.6828	3.79	Yes	Yes	0	5	6
59	R:R:I279	R:R:Q280	23.1097	4.12	Yes	Yes	0	7	7
60	R:R:Q280	R:R:W276	14.0889	4.38	Yes	Yes	1	7	8
61	R:R:L212	R:R:Q127	16.8936	6.65	No	Yes	0	6	6
62	R:R:C130	R:R:T129	19.8048	1.69	No	No	0	7	9
63	R:R:C130	R:R:P216	17.3856	3.77	No	No	0	7	9
64	R:R:F272	R:R:W276	49.1963	3.01	No	Yes	0	9	8
65	R:R:F272	R:R:L133	48.1548	3.65	No	No	0	9	8
66	R:R:L133	R:R:T220	46.8509	4.42	No	No	0	8	8
67	R:R:M136	R:R:R140	11.6123	3.72	No	No	1	9	9
68	R:R:R140	R:R:Y323	23.8314	5.14	No	Yes	1	9	9
69	R:R:S137	R:R:T220	15.9341	6.4	No	No	1	9	8
70	R:R:C223	R:R:S137	21.8386	5.16	No	No	0	7	9
71	R:R:T220	R:R:Y224	29.7933	2.5	No	Yes	1	8	9
72	R:R:C223	R:R:W141	16.4753	2.61	No	No	0	7	8
73	R:R:V145	R:R:W141	11.0464	11.03	No	No	0	7	8
74	R:R:R154	R:R:Y142	28.1778	4.12	Yes	No	0	7	4
75	R:R:R149	R:R:Y142	20.2067	3.09	No	No	0	5	4
76	R:R:R149	R:R:R153	16.1965	7.46	No	No	0	5	4
77	R:R:H181	R:R:L180	24.8893	3.86	Yes	No	0	5	4
78	R:R:E193	R:R:L180	20.018	5.3	Yes	No	0	4	4
79	L:L:N2	R:R:Y190	12.908	3.49	No	No	0	0	4
80	R:R:E193	R:R:E201	12.5472	17.76	Yes	No	4	4	4
81	R:R:E201	R:R:P196	10.1935	1.57	No	No	0	4	4
82	L:L:R7	R:R:F204	10.1033	8.55	Yes	No	0	0	5
83	R:R:L215	R:R:P216	10.0295	1.64	No	No	0	6	9
84	R:R:G277	R:R:Y213	20.8873	5.79	No	Yes	0	6	8
85	R:R:V265	R:R:Y224	38.7978	10.09	No	Yes	0	8	9
86	R:R:V261	R:R:V265	30.0886	1.6	No	No	0	8	8
87	R:R:L228	R:R:V261	27.1527	2.98	No	No	0	5	8
88	R:R:L228	R:R:S262	24.2004	7.51	No	No	0	5	7
89	R:R:R258	R:R:S262	21.2318	1.32	No	No	0	7	7
90	R:R:G232	R:R:R258	12.2273	3	No	No	0	5	7
91	R:R:L322	R:R:Y323	25.2091	2.34	Yes	Yes	0	8	9
92	R:R:G277	R:R:P278	17.9515	4.06	No	No	0	6	9
93	R:R:P278	R:R:W307	14.9992	5.4	No	No	0	9	5
94	R:R:F282	R:R:K305	46.6541	11.17	No	No	0	5	4
95	R:R:A301	R:R:F282	42.1273	1.39	No	No	0	6	5
96	L:L:F4	L:L:N2	14.7696	6.04	Yes	No	0	0	0
97	L:L:F4	R:R:R297	12.703	19.24	Yes	No	0	0	2
98	R:R:M311	R:R:W307	12.0305	10.47	No	No	0	7	5
99	R:R:H152	R:R:R153	12.1699	2.26	No	No	0	5	4
100	L:L:?9	R:R:Y313	10.9726	2.9	Yes	Yes	1	0	7
101	R:R:L212	R:R:V126	14.9336	4.47	No	Yes	0	6	7
102	R:R:V126	R:R:W276	56.7656	2.45	Yes	Yes	1	7	8
103	R:R:R140	R:R:Y224	31.6631	13.38	No	Yes	1	9	9
104	R:R:W276	R:R:Y213	16.8033	5.79	Yes	Yes	1	8	8
105	L:L:F4	R:R:A301	30.761	1.39	Yes	No	0	0	6
106	R:R:L84	R:R:T132	11.3744	7.37	Yes	No	0	9	8
107	R:R:F91	R:R:L92	12.2519	3.65	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F49	R:R:V96	2.62	1	Yes	Yes	7	8	2	2
R:R:F49	R:R:T99	2.59	1	Yes	Yes	7	6	2	1
R:R:F49	R:R:Y313	7.22	1	Yes	Yes	7	7	2	1
R:R:C95	R:R:F91	6.98	1	No	Yes	7	7	2	2
R:R:F91	R:R:S125	7.93	1	Yes	No	7	8	2	2
R:R:F91	R:R:V126	2.62	1	Yes	Yes	7	7	2	1
R:R:F91	R:R:Y313	4.13	1	Yes	Yes	7	7	2	1
R:R:C95	R:R:Q122	12.21	1	No	No	7	6	2	1
R:R:C95	R:R:Y313	6.72	1	No	Yes	7	7	2	1
R:R:V96	R:R:Y313	5.05	1	Yes	Yes	8	7	2	1
R:R:F98	R:R:V118	6.55	0	No	No	6	5	2	1
R:R:H309	R:R:T99	6.85	1	Yes	Yes	6	6	1	1
R:R:T99	R:R:Y313	3.75	1	Yes	Yes	6	7	1	1
L:L:?9	R:R:T99	10.94	1	Yes	Yes	0	6	0	1
R:R:C115	R:R:W108	7.84	3	No	Yes	9	8	2	2
R:R:V118	R:R:W108	3.68	0	No	Yes	5	8	1	2
R:R:C115	R:R:N119	3.15	3	No	No	9	5	2	1
L:L:L6	R:R:V118	2.98	0	No	No	0	5	0	1
R:R:H181	R:R:N119	28.06	0	Yes	No	5	5	1	1
L:L:L6	R:R:N119	9.61	0	No	No	0	5	0	1
R:R:I121	R:R:Q122	2.74	0	No	No	5	6	2	1
L:L:?9	R:R:Q122	3.29	1	Yes	No	0	6	0	1
R:R:Q123	R:R:S174	2.89	1	No	No	4	7	1	2
L:L:R7	R:R:Q123	4.67	1	Yes	No	0	4	0	1
L:L:F8	R:R:Q123	7.03	1	Yes	No	0	4	0	1
R:R:S125	R:R:V126	3.23	1	No	Yes	8	7	2	1
R:R:L212	R:R:V126	4.47	0	No	Yes	6	7	2	1
R:R:V126	R:R:W276	2.45	1	Yes	Yes	7	8	1	2
L:L:F8	R:R:V126	5.24	1	Yes	Yes	0	7	0	1
R:R:H181	R:R:V177	2.77	0	Yes	No	5	5	1	2
R:R:H181	R:R:L180	3.86	0	Yes	No	5	4	1	2
L:L:R7	R:R:H181	12.41	1	Yes	Yes	0	5	0	1
R:R:R188	R:R:Y190	3.09	0	No	No	2	4	2	1
L:L:N2	R:R:Y190	3.49	0	No	No	0	4	0	1
L:L:S3	R:R:Y190	7.63	0	No	No	0	4	0	1
R:R:F204	R:R:N208	4.83	0	No	No	5	5	1	2
L:L:R7	R:R:F204	8.55	1	Yes	No	0	5	0	1
R:R:I279	R:R:L283	2.85	0	Yes	No	7	5	2	1
R:R:H309	R:R:I279	2.65	1	Yes	Yes	6	7	1	2
R:R:F282	R:R:K305	11.17	0	No	No	5	4	2	2
L:L:R7	R:R:L283	3.64	1	Yes	No	0	5	0	1
R:R:Q286	R:R:R297	4.67	0	No	No	4	2	2	1
R:R:A301	R:R:W294	5.19	0	No	No	6	1	1	2
R:R:H295	R:R:R297	3.39	0	No	No	3	2	2	1
L:L:F4	R:R:R297	19.24	0	Yes	No	0	2	0	1
L:L:W1	R:R:Y299	6.75	0	No	No	0	4	0	1
R:R:H309	R:R:K305	13.1	1	Yes	No	6	4	1	2
R:R:H309	R:R:Y313	9.8	1	Yes	Yes	6	7	1	1
L:L:?9	R:R:H309	9.55	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:Y313	2.9	1	Yes	Yes	0	7	0	1
R:R:Y299	R:R:Y302	1.99	0	No	Yes	4	5	1	2
R:R:A301	R:R:F282	1.39	0	No	No	6	5	1	2
L:L:F4	R:R:A301	1.39	0	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XGS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.45
Number of Linked Nodes	273
Number of Links	297
Number of Hubs	38
Number of Links mediated by Hubs	138
Number of Communities	5
Number of Nodes involved in Communities	40
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	108
Number Of Links MetaPath	107
Number of Shortest Paths	41450
Length Of Smallest Path	3
Average Path Length	13.1318
Length of Longest Path	36
Minimum Path Strength	1.26
Average Path Strength	5.7281
Maximum Path Strength	20.235
Minimum Path Correlation	0.7
Average Path Correlation	0.93561
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	57.3078
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9745
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969F8
Sequence	>8XGS_nogp_Chain_R A V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H K P M R T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y P L P G W V L G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F P L R A L H R R T P R L A L A V S L S I W V G S A A V S A P V L A L H R L S P G P R A Y C S E A F P S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V A V D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G P A G S W H P R S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R Q A F R R V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XGS	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-	chim(NtGi1-Gq)/β1/γ2	2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-		2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ2	2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	Gi1/β1/γ2	3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8ZJE	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-	chim(NtGi1-Gq)/β1/γ1	3.07	2024-07-03	To be published
	8ZJE (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-		3.07	2024-07-03	To be published
	8ZJD	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-	chim(NtGi1-Gq)/β1/γ1	3.06	2024-07-03	To be published
	8ZJD (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-		3.06	2024-07-03	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XGS_nogp.zip

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