psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L47	R:R:W43	4.56	No	No	0	6	2
2	R:R:F49	R:R:V45	7.87	Yes	No	1	7	5
3	R:R:L102	R:R:V45	13.41	Yes	No	1	5	5
4	R:R:L102	R:R:P46	3.28	Yes	No	0	5	6
5	R:R:F49	R:R:L102	3.65	Yes	Yes	1	7	5
6	R:R:C310	R:R:F49	5.59	No	Yes	0	5	7
7	R:R:F49	R:R:Y313	7.22	Yes	Yes	1	7	7
8	R:R:L52	R:R:Y313	3.52	No	Yes	0	7	7
9	R:R:L57	R:R:M53	5.65	No	No	0	6	7
10	R:R:L92	R:R:M53	5.65	No	No	0	7	7
11	R:R:M53	R:R:V96	4.56	No	No	0	7	8
12	R:R:G59	R:R:V58	3.68	No	No	0	8	4
13	R:R:A85	R:R:N60	4.69	No	No	0	9	9
14	R:R:D88	R:R:N60	6.73	Yes	No	0	9	9
15	R:R:N60	R:R:P320	6.52	No	No	0	9	9
16	R:R:A85	R:R:V63	3.39	No	No	0	9	9
17	R:R:F330	R:R:V63	3.93	Yes	No	0	8	9
18	R:R:A85	R:R:I64	3.25	No	No	0	9	7
19	R:R:F330	R:R:V66	6.55	Yes	No	0	8	7
20	R:R:I67	R:R:N78	5.66	No	No	0	7	8
21	R:R:A82	R:R:I67	3.25	No	No	0	6	7
22	R:R:F330	R:R:I67	3.77	Yes	No	0	8	7
23	R:R:M73	R:R:N78	7.01	Yes	No	0	7	8
24	R:R:A333	R:R:M73	3.22	No	Yes	0	6	7
25	R:R:M73	R:R:R336	3.72	Yes	No	0	7	5
26	R:R:F79	R:R:R74	10.69	Yes	No	0	6	7
27	R:R:P156	R:R:R74	4.32	No	No	0	1	7
28	R:R:N78	R:R:T75	4.39	No	No	0	8	7
29	R:R:R154	R:R:V76	10.46	Yes	No	0	7	6
30	R:R:P156	R:R:V76	5.3	No	No	0	1	6
31	R:R:R154	R:R:T77	7.76	Yes	No	0	7	8
32	R:R:A159	R:R:F79	4.16	No	Yes	0	7	6
33	R:R:D139	R:R:Y80	13.79	No	No	0	8	7
34	R:R:A159	R:R:Y80	5.34	No	No	0	7	7
35	R:R:V162	R:R:Y80	3.79	No	No	0	5	7
36	R:R:N83	R:R:S163	8.94	No	No	0	9	8
37	R:R:D88	R:R:L84	8.14	Yes	Yes	0	9	9
38	R:R:L84	R:R:T132	4.42	Yes	No	0	9	8
39	R:R:L133	R:R:L84	5.54	No	Yes	2	8	9
40	R:R:L84	R:R:M136	5.65	Yes	No	2	9	9
41	R:R:L84	R:R:Y323	7.03	Yes	Yes	2	9	9
42	R:R:D88	R:R:T87	4.34	Yes	Yes	0	9	8
43	R:R:T132	R:R:T87	10.99	No	Yes	0	8	8
44	R:R:T87	R:R:W167	4.85	Yes	No	0	8	9
45	R:R:D88	R:R:T129	4.34	Yes	No	0	9	9
46	R:R:D88	R:R:N319	9.42	Yes	Yes	0	9	9
47	R:R:C95	R:R:F91	4.19	Yes	No	0	7	7
48	R:R:F91	R:R:S125	5.28	No	No	0	7	8
49	R:R:F91	R:R:S316	7.93	No	No	0	7	9
50	R:R:L92	R:R:S316	6.01	No	No	0	7	9
51	R:R:C94	R:R:I121	6.55	No	No	0	4	5
52	R:R:C94	R:R:S125	5.16	No	No	0	4	8
53	R:R:C95	R:R:Q122	6.1	Yes	No	1	7	6
54	R:R:C95	R:R:Y313	6.72	Yes	Yes	1	7	7
55	L:L:?11	R:R:C95	3.93	Yes	Yes	1	0	7
56	R:R:P97	R:R:V96	3.53	No	No	0	9	8
57	R:R:P97	R:R:V118	3.53	No	No	0	9	5
58	R:R:F98	R:R:L101	4.87	Yes	Yes	1	6	4
59	R:R:F98	R:R:L102	7.31	Yes	Yes	1	6	5
60	R:R:F98	R:R:H309	14.71	Yes	Yes	1	6	6
61	R:R:F98	R:R:Y313	4.13	Yes	Yes	1	6	7
62	L:L:L8	R:R:F98	3.65	Yes	Yes	1	0	6
63	R:R:L101	R:R:W108	4.56	Yes	Yes	1	4	8
64	L:L:N4	R:R:L101	8.24	No	Yes	0	0	4
65	L:L:L8	R:R:L101	5.54	Yes	Yes	1	0	4
66	L:L:T5	R:R:L102	7.37	No	Yes	0	0	5
67	R:R:P104	R:R:Y103	12.52	No	No	0	5	5
68	R:R:L105	R:R:Y103	10.55	No	No	0	4	5
69	R:R:L105	R:R:P106	3.28	No	No	0	4	5
70	R:R:L105	R:R:V109	7.45	No	No	0	4	3
71	L:L:N4	R:R:G107	5.09	No	No	0	0	5
72	R:R:L110	R:R:W108	10.25	No	Yes	0	7	8
73	R:R:C115	R:R:W108	3.92	No	Yes	1	9	8
74	R:R:L183	R:R:W108	5.69	No	Yes	0	3	8
75	R:R:C191	R:R:W108	11.75	No	Yes	1	9	8
76	R:R:L110	R:R:M114	5.65	No	No	0	7	6
77	R:R:D112	R:R:K116	11.06	No	No	0	3	7
78	R:R:D112	R:R:L183	6.79	No	No	0	3	3
79	R:R:C115	R:R:C191	5.46	No	No	1	9	9
80	L:L:L8	R:R:V118	5.96	Yes	No	0	0	5
81	R:R:H181	R:R:N119	25.51	No	No	1	5	5
82	L:L:L8	R:R:N119	8.24	Yes	No	1	0	5
83	L:L:?9	R:R:N119	4.36	Yes	No	1	0	5
84	R:R:V124	R:R:Y120	6.31	No	Yes	1	5	6
85	R:R:S174	R:R:Y120	8.9	Yes	Yes	1	7	6
86	R:R:L178	R:R:Y120	15.24	No	Yes	0	5	6
87	L:L:L8	R:R:Q122	7.99	Yes	No	1	0	6
88	L:L:?11	R:R:Q122	9.88	Yes	No	1	0	6
89	R:R:Q123	R:R:Q127	5.12	Yes	Yes	1	4	6
90	R:R:Q123	R:R:V177	5.73	Yes	No	0	4	5
91	R:R:F204	R:R:Q123	4.68	No	Yes	1	5	4
92	R:R:N208	R:R:Q123	5.28	Yes	Yes	1	5	4
93	L:L:W10	R:R:Q123	9.86	Yes	Yes	1	0	4
94	R:R:S170	R:R:V124	6.46	No	No	0	7	5
95	R:R:S174	R:R:V124	4.85	Yes	No	1	7	5
96	R:R:V126	R:R:W276	4.9	No	Yes	0	7	8
97	L:L:W10	R:R:V126	15.94	Yes	No	0	0	7
98	R:R:Q127	R:R:W131	16.43	Yes	No	0	6	6
99	R:R:Q127	R:R:Y207	5.64	Yes	No	0	6	4
100	R:R:L212	R:R:Q127	6.65	Yes	Yes	1	6	6
101	R:R:A128	R:R:W167	7.78	No	No	0	7	9
102	R:R:C130	R:R:L212	4.76	No	Yes	0	7	6
103	R:R:L133	R:R:N319	5.49	No	Yes	2	8	9
104	R:R:L133	R:R:Y323	4.69	No	Yes	2	8	9
105	R:R:P216	R:R:T134	3.5	No	No	0	9	7
106	R:R:M136	R:R:Y323	4.79	No	Yes	2	9	9
107	R:R:S137	R:R:T220	9.59	No	No	4	9	8
108	R:R:C223	R:R:S137	5.16	No	No	0	7	9
109	R:R:S137	R:R:Y224	5.09	No	Yes	4	9	9
110	R:R:C223	R:R:V138	3.42	No	No	0	7	7
111	R:R:D139	R:R:R154	11.91	No	Yes	0	8	7
112	R:R:R140	R:R:Y224	10.29	No	Yes	0	9	9
113	R:R:R140	R:R:Y323	7.2	No	Yes	0	9	9
114	R:R:V145	R:R:W141	8.58	No	No	0	7	8
115	R:R:F146	R:R:Y142	7.22	Yes	Yes	3	6	4
116	R:R:R149	R:R:Y142	5.14	No	Yes	3	5	4
117	R:R:R153	R:R:Y142	6.17	No	Yes	3	4	4
118	R:R:R154	R:R:V143	6.54	Yes	No	0	7	8
119	R:R:M227	R:R:T144	9.03	No	No	0	9	8
120	R:R:L231	R:R:T144	4.42	No	No	0	8	8
121	R:R:F146	R:R:V145	9.18	Yes	No	0	6	7
122	R:R:H230	R:R:V145	5.54	No	No	0	5	7
123	R:R:F146	R:R:R149	5.34	Yes	No	3	6	5
124	R:R:R149	R:R:R153	5.33	No	No	3	5	4
125	R:R:P156	R:R:T155	3.5	No	No	0	1	7
126	R:R:V173	R:R:Y207	3.79	No	No	0	5	4
127	R:R:F195	R:R:L180	7.31	Yes	Yes	1	6	4
128	L:L:?9	R:R:L180	3.29	Yes	Yes	1	0	4
129	L:L:?9	R:R:H181	12.24	Yes	No	1	0	5
130	R:R:A194	R:R:R182	6.91	No	No	0	3	5
131	R:R:S184	R:R:Y190	3.82	No	No	0	3	4
132	R:R:S184	R:R:S192	6.52	No	No	0	3	4
133	L:L:?3	R:R:Y190	24.65	Yes	No	0	0	4
134	L:L:N4	R:R:Y190	5.81	No	No	0	0	4
135	L:L:?7	R:R:C191	4.6	No	No	0	0	9
136	R:R:E193	R:R:F195	4.66	No	Yes	0	4	6
137	R:R:E201	R:R:F195	13.99	No	Yes	0	4	6
138	R:R:F195	R:R:F204	7.5	Yes	No	1	6	5
139	L:L:?9	R:R:F195	6.76	Yes	Yes	1	0	6
140	R:R:L200	R:R:P196	6.57	No	No	0	3	4
141	R:R:L200	R:R:S197	4.5	No	No	0	3	3
142	R:R:E201	R:R:R198	9.3	No	No	0	4	1
143	R:R:R198	R:R:R202	4.26	No	No	0	1	1
144	L:L:?9	R:R:F204	14.49	Yes	No	1	0	5
145	R:R:A211	R:R:Y207	5.34	No	No	0	4	4
146	R:R:L212	R:R:N208	9.61	Yes	Yes	1	6	5
147	R:R:N208	R:R:Q280	6.6	Yes	Yes	1	5	7
148	R:R:L283	R:R:N208	5.49	No	Yes	0	5	5
149	L:L:W10	R:R:N208	7.91	Yes	Yes	1	0	5
150	R:R:L209	R:R:Y213	3.52	No	Yes	1	5	8
151	R:R:L209	R:R:Q280	5.32	No	Yes	1	5	7
152	R:R:L212	R:R:Q280	3.99	Yes	Yes	1	6	7
153	R:R:L217	R:R:Y213	3.52	Yes	Yes	0	6	8
154	R:R:G277	R:R:Y213	5.79	No	Yes	0	6	8
155	R:R:Q280	R:R:Y213	6.76	Yes	Yes	1	7	8
156	R:R:F272	R:R:L217	3.65	No	Yes	0	9	6
157	R:R:T220	R:R:Y224	3.75	No	Yes	4	8	9
158	R:R:V265	R:R:Y224	17.66	No	Yes	0	8	9
159	R:R:L228	R:R:S262	4.5	Yes	No	0	5	7
160	R:R:L231	R:R:V261	4.47	No	No	0	8	8
161	R:R:P240	R:R:V249	3.53	No	No	0	4	2
162	R:R:D242	R:R:L245	4.07	No	No	0	4	3
163	R:R:E252	R:R:Q248	5.1	No	No	0	3	4
164	R:R:L250	R:R:V249	4.47	No	No	0	3	2
165	R:R:A251	R:R:E252	4.53	No	No	0	1	3
166	R:R:L322	R:R:V268	4.47	No	No	0	8	8
167	R:R:V268	R:R:Y323	6.31	No	Yes	0	8	9
168	R:R:L271	R:R:L318	5.54	No	No	0	7	6
169	R:R:L271	R:R:L322	5.54	No	No	0	7	8
170	R:R:F272	R:R:W276	8.02	No	Yes	0	9	8
171	R:R:C275	R:R:N315	4.72	No	No	0	9	9
172	R:R:S312	R:R:W276	3.71	No	Yes	0	7	8
173	R:R:N315	R:R:W276	12.43	No	Yes	0	9	8
174	R:R:G277	R:R:P278	4.06	No	No	0	6	9
175	R:R:P278	R:R:W307	6.76	No	No	5	9	5
176	R:R:M311	R:R:P278	3.35	No	No	5	7	9
177	R:R:A308	R:R:I279	4.87	No	No	0	6	7
178	L:L:W10	R:R:I279	8.22	Yes	No	0	0	7
179	L:L:W10	R:R:Q280	4.38	Yes	Yes	1	0	7
180	R:R:L281	R:R:L285	5.54	No	No	1	6	6
181	R:R:F282	R:R:Q286	5.86	Yes	No	1	5	4
182	R:R:F282	R:R:K305	19.85	Yes	Yes	1	5	4
183	L:L:F6	R:R:F282	4.29	Yes	Yes	1	0	5
184	R:R:L285	R:R:W294	10.25	No	No	0	6	1
185	L:L:F6	R:R:Q286	7.03	Yes	No	1	0	4
186	R:R:G289	R:R:P290	4.06	No	No	0	3	1
187	R:R:G289	R:R:P296	4.06	No	No	0	3	3
188	R:R:A301	R:R:W294	3.89	No	No	0	6	1
189	R:R:H295	R:R:P296	4.58	No	No	0	3	3
190	R:R:H295	R:R:R297	11.28	No	No	0	3	2
191	L:L:F6	R:R:R297	3.21	Yes	No	0	0	2
192	R:R:Y299	R:R:Y302	7.94	No	No	0	4	5
193	L:L:?2	R:R:Y299	5.63	No	No	0	0	4
194	R:R:T306	R:R:Y302	6.24	No	No	0	4	5
195	L:L:T5	R:R:Y302	7.49	No	No	0	0	5
196	R:R:H309	R:R:K305	11.79	Yes	Yes	1	6	4
197	L:L:F6	R:R:K305	4.96	Yes	Yes	1	0	4
198	L:L:?9	R:R:K305	3.36	Yes	Yes	1	0	4
199	R:R:M311	R:R:W307	5.82	No	No	5	7	5
200	R:R:H309	R:R:Y313	5.44	Yes	Yes	1	6	7
201	L:L:?11	R:R:H309	6.36	Yes	Yes	1	0	6
202	R:R:S312	R:R:Y313	5.09	No	Yes	0	7	7
203	R:R:N315	R:R:N319	9.54	No	Yes	0	9	9
204	R:R:N319	R:R:Y323	4.65	Yes	Yes	2	9	9
205	R:R:L321	R:R:L326	4.15	No	No	0	7	7
206	R:R:A324	R:R:F330	8.32	No	Yes	0	7	8
207	R:R:F325	R:R:F330	8.57	No	Yes	0	6	8
208	L:L:?1	L:L:?2	24.2	No	No	1	0	0
209	L:L:?1	L:L:?3	3.25	No	Yes	1	0	0
210	L:L:?1	L:L:T5	5.69	No	No	0	0	0
211	L:L:?2	L:L:?3	24.28	No	Yes	1	0	0
212	L:L:?3	L:L:F6	3.34	Yes	Yes	1	0	0
213	L:L:?3	L:L:?7	3.67	Yes	No	0	0	0
214	L:L:?7	L:L:L8	5.35	No	Yes	0	0	0
215	L:L:?9	L:L:L8	3.29	Yes	Yes	1	0	0
216	L:L:?9	L:L:W10	12.65	Yes	Yes	1	0	0
217	L:L:?11	L:L:W10	8.46	Yes	Yes	1	0	0
218	R:R:C221	R:R:L217	3.17	No	Yes	0	5	6
219	R:R:T220	R:R:V269	3.17	No	No	0	8	8
220	R:R:A273	R:R:L217	3.15	No	Yes	0	5	6
221	R:R:L57	R:R:S61	3	No	No	0	6	4
222	R:R:G232	R:R:R258	3	No	No	0	5	7
223	R:R:L57	R:R:V89	2.98	No	No	0	6	7
224	R:R:L62	R:R:V58	2.98	No	No	0	6	4
225	R:R:L93	R:R:V89	2.98	No	No	0	5	7
226	R:R:L110	R:R:V109	2.98	No	No	0	7	3
227	R:R:L209	R:R:V284	2.98	No	No	0	5	5
228	R:R:L228	R:R:V261	2.98	Yes	No	0	5	8
229	R:R:L228	R:R:V265	2.98	Yes	No	0	5	8
230	R:R:D242	R:R:S243	2.94	No	No	0	4	4
231	R:R:N83	R:R:T87	2.92	No	Yes	0	9	8
232	R:R:Q123	R:R:S174	2.89	Yes	Yes	1	4	7
233	R:R:Q127	R:R:S170	2.89	Yes	No	0	6	7
234	R:R:Q127	R:R:S174	2.89	Yes	Yes	1	6	7
235	R:R:L44	R:R:L47	2.77	No	No	0	5	6
236	R:R:L148	R:R:L151	2.77	No	No	0	6	4
237	R:R:L160	R:R:L164	2.77	No	No	0	3	4
238	R:R:A199	R:R:R202	2.77	No	No	0	1	1
239	R:R:L210	R:R:L215	2.77	No	No	0	5	6
240	R:R:H230	R:R:V234	2.77	No	No	0	5	6
241	R:R:L264	R:R:L326	2.77	No	No	0	8	7
242	R:R:L322	R:R:L326	2.77	No	No	0	8	7
243	R:R:P216	R:R:W131	2.7	No	No	0	9	6
244	R:R:L245	R:R:Q248	2.66	No	No	0	3	4
245	R:R:H329	R:R:M73	2.63	No	Yes	0	6	7
246	R:R:A226	R:R:W141	2.59	No	No	0	5	8
247	R:R:R157	R:R:T155	2.59	No	No	0	4	7
248	R:R:F325	R:R:L62	2.44	No	No	0	6	6
249	R:R:F79	R:R:L160	2.44	Yes	No	0	6	3
250	R:R:F282	R:R:L304	2.44	Yes	No	1	5	6
251	R:R:T90	R:R:W167	2.43	No	No	0	6	9
252	R:R:F79	R:R:N83	2.42	Yes	No	0	6	9
253	R:R:I166	R:R:W131	2.35	No	No	0	7	6
254	R:R:L214	R:R:Y213	2.34	No	Yes	0	4	8
255	R:R:H152	R:R:R153	2.26	No	No	0	5	4
256	R:R:F113	R:R:F117	2.14	No	No	0	3	5
257	R:R:R154	R:R:Y142	2.06	Yes	Yes	0	7	4
258	R:R:A317	R:R:G56	1.95	No	No	0	7	8
259	R:R:A172	R:R:G169	1.95	No	No	0	4	4
260	R:R:A175	R:R:P176	1.87	No	No	0	5	6
261	R:R:A205	R:R:A287	1.79	No	No	0	5	5
262	R:R:P185	R:R:S184	1.78	No	No	0	2	3
263	R:R:P46	R:R:T99	1.75	No	No	0	6	6
264	R:R:G111	R:R:M114	1.75	No	No	0	8	6
265	R:R:C275	R:R:S314	1.72	No	No	0	9	5
266	R:R:G56	R:R:L55	1.71	No	No	0	8	6
267	R:R:G56	R:R:L92	1.71	No	No	0	8	7
268	R:R:A171	R:R:S170	1.71	No	No	0	4	7
269	R:R:A199	R:R:S197	1.71	No	No	0	1	3
270	R:R:G289	R:R:L288	1.71	No	No	0	3	4
271	R:R:A300	R:R:S298	1.71	No	No	0	3	4
272	R:R:A135	R:R:V162	1.7	No	No	0	7	5
273	R:R:A150	R:R:V143	1.7	No	No	0	6	8
274	R:R:A219	R:R:T134	1.68	No	No	0	6	7
275	R:R:A303	R:R:T306	1.68	No	No	0	2	4
276	R:R:C68	R:R:I64	1.64	No	No	0	4	7
277	R:R:L180	R:R:P176	1.64	Yes	No	0	4	6
278	R:R:L215	R:R:P216	1.64	No	No	0	6	9
279	R:R:L245	R:R:P240	1.64	No	No	0	3	4
280	R:R:G247	R:R:Q246	1.64	No	No	0	4	4
281	R:R:V257	R:R:V261	1.6	No	No	0	6	8
282	R:R:A179	R:R:L180	1.58	No	Yes	0	4	4
283	R:R:P240	R:R:Q246	1.58	No	No	0	4	4
284	R:R:I81	R:R:V63	1.54	No	No	0	8	9
285	R:R:A244	R:R:D242	1.54	No	No	0	4	4
286	R:R:L158	R:R:V162	1.49	No	No	0	4	5
287	R:R:F146	R:R:P147	1.44	Yes	No	0	6	8
288	R:R:H295	R:R:S298	1.39	No	No	0	3	4
289	R:R:L206	R:R:L210	1.38	No	No	0	5	5
290	R:R:L281	R:R:L304	1.38	No	No	1	6	6
291	R:R:L285	R:R:L304	1.38	No	No	1	6	6
292	R:R:R263	R:R:S262	1.32	No	No	0	7	7
293	R:R:F334	R:R:V66	1.31	No	No	0	6	7
294	R:R:R253	R:R:V257	1.31	No	No	0	3	6
295	R:R:H152	R:R:L151	1.29	No	No	0	5	4
296	R:R:K116	R:R:R182	1.24	No	No	0	7	5
297	R:R:F48	R:R:L44	1.22	No	No	0	4	5
298	R:R:F48	R:R:L52	1.22	No	No	0	4	7
299	R:R:L228	R:R:R258	1.21	Yes	No	0	5	7
300	R:R:Q248	R:R:R253	1.17	No	No	0	4	3
301	R:R:Q332	R:R:R335	1.17	No	No	0	5	4
302	R:R:R331	R:R:R335	1.07	No	No	0	8	4
303	R:R:F334	R:R:R335	1.07	No	No	0	6	4
304	R:R:F117	R:R:Y120	1.03	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F49	6.0825	4	1	7
2	R:R:M73	4.145	4	0	7
3	R:R:F79	4.9275	4	0	6
4	R:R:L84	6.156	5	2	9
5	R:R:T87	5.775	4	0	8
6	R:R:D88	6.594	5	0	9
7	R:R:C95	5.235	4	1	7
8	R:R:F98	6.934	5	1	6
9	R:R:L101	5.8025	4	1	4
10	R:R:L102	7.004	5	1	5
11	R:R:W108	7.234	5	1	8
12	R:R:Y120	7.87	4	1	6
13	R:R:Q123	5.59333	6	1	4
14	R:R:Q127	6.60333	6	1	6
15	R:R:Y142	5.1475	4	3	4
16	R:R:F146	5.795	4	3	6
17	R:R:R154	7.746	5	0	7
18	R:R:S174	4.8825	4	1	7
19	R:R:L180	3.455	4	1	4
20	R:R:F195	8.044	5	1	6
21	R:R:N208	6.978	5	1	5
22	R:R:L212	6.2525	4	1	6
23	R:R:Y213	4.386	5	1	8
24	R:R:L217	3.3725	4	0	6
25	R:R:Y224	9.1975	4	4	9
26	R:R:L228	2.9175	4	0	5
27	R:R:W276	7.265	4	0	8
28	R:R:Q280	5.41	5	1	7
29	R:R:F282	8.11	4	1	5
30	R:R:K305	9.99	4	1	4
31	R:R:H309	9.575	4	1	6
32	R:R:Y313	5.35333	6	1	7
33	R:R:N319	7.275	4	2	9
34	R:R:Y323	5.77833	6	2	9
35	R:R:F330	6.228	5	0	8
36	L:L:?3	11.838	5	1	0
37	L:L:F6	4.566	5	1	0
38	L:L:L8	5.71714	7	1	0
39	L:L:?9	7.555	8	1	0
40	L:L:W10	9.63143	7	1	0
41	L:L:?11	7.1575	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F98	R:R:L102	11.4189	7.31	Yes	Yes	1	6	5
2	R:R:F98	R:R:Y313	25.4512	4.13	Yes	Yes	1	6	7
3	R:R:C95	R:R:Y313	12.8329	6.72	Yes	Yes	1	7	7
4	R:R:C95	R:R:F91	15.6915	4.19	Yes	No	0	7	7
5	R:R:F91	R:R:S316	10.5721	7.93	No	No	0	7	9
6	R:R:F330	R:R:V63	25.1868	3.93	Yes	No	0	8	9
7	R:R:A85	R:R:V63	27.6775	3.39	No	No	0	9	9
8	R:R:A85	R:R:N60	31.3561	4.69	No	No	0	9	9
9	R:R:D88	R:R:N60	33.7702	6.73	Yes	No	0	9	9
10	R:R:D88	R:R:N319	77.3805	9.42	Yes	Yes	0	9	9
11	R:R:N315	R:R:N319	99.2643	9.54	No	Yes	0	9	9
12	R:R:N315	R:R:W276	100	12.43	No	Yes	0	9	8
13	R:R:S312	R:R:W276	52.8413	3.71	No	Yes	0	7	8
14	R:R:S312	R:R:Y313	52.5923	5.09	No	Yes	0	7	7
15	R:R:F330	R:R:I67	10.94	3.77	Yes	No	0	8	7
16	R:R:F79	R:R:N83	65.8428	2.42	Yes	No	0	6	9
17	R:R:N83	R:R:T87	68.2032	2.92	No	Yes	0	9	8
18	R:R:D88	R:R:T87	64.8044	4.34	Yes	Yes	0	9	8
19	R:R:F79	R:R:R74	30.5131	10.69	Yes	No	0	6	7
20	R:R:P156	R:R:R74	29.1911	4.32	No	No	0	1	7
21	R:R:P156	R:R:V76	25.2366	5.3	No	No	0	1	6
22	R:R:R154	R:R:V76	23.9223	10.46	Yes	No	0	7	6
23	R:R:A159	R:R:F79	31.8964	4.16	No	Yes	0	7	6
24	R:R:A159	R:R:Y80	30.5821	5.34	No	No	0	7	7
25	R:R:D139	R:R:Y80	25.3094	13.79	No	No	0	8	7
26	R:R:D139	R:R:R154	23.9874	11.91	No	Yes	0	8	7
27	R:R:D88	R:R:L84	14.8255	8.14	Yes	Yes	0	9	9
28	R:R:N319	R:R:Y323	44.1545	4.65	Yes	Yes	2	9	9
29	R:R:L84	R:R:Y323	22.1443	7.03	Yes	Yes	2	9	9
30	R:R:L84	R:R:T132	11.2427	4.42	Yes	No	0	9	8
31	R:R:H309	R:R:Y313	14.4231	5.44	Yes	Yes	1	6	7
32	R:R:F98	R:R:L101	15.4002	4.87	Yes	Yes	1	6	4
33	R:R:L101	R:R:W108	17.8488	4.56	Yes	Yes	1	4	8
34	L:L:T5	R:R:L102	11.1201	7.37	No	Yes	0	0	5
35	R:R:L110	R:R:W108	10.1123	10.25	No	Yes	0	7	8
36	L:L:?9	L:L:L8	22.6693	3.29	Yes	Yes	1	0	0
37	L:L:?9	R:R:K305	20.2667	3.36	Yes	Yes	1	0	4
38	R:R:H309	R:R:K305	14.1855	11.79	Yes	Yes	1	6	4
39	L:L:W10	R:R:Q123	23.6157	9.86	Yes	Yes	1	0	4
40	R:R:Q123	R:R:Q127	19.987	5.12	Yes	Yes	1	4	6
41	R:R:V126	R:R:W276	43.4494	4.9	No	Yes	0	7	8
42	R:R:Q127	R:R:W131	12.3194	16.43	Yes	No	0	6	6
43	L:L:W10	R:R:Q280	10.1966	4.38	Yes	Yes	1	0	7
44	R:R:R140	R:R:Y323	50.8334	7.2	No	Yes	0	9	9
45	R:R:R140	R:R:Y224	49.3658	10.29	No	Yes	0	9	9
46	R:R:R154	R:R:Y142	36.7092	2.06	Yes	Yes	0	7	4
47	R:R:F146	R:R:Y142	19.8988	7.22	Yes	Yes	3	6	4
48	R:R:F146	R:R:V145	14.3465	9.18	Yes	No	0	6	7
49	R:R:R153	R:R:Y142	11.4151	6.17	No	Yes	3	4	4
50	R:R:V265	R:R:Y224	40.0314	17.66	No	Yes	0	8	9
51	R:R:L228	R:R:V265	38.4489	2.98	Yes	No	0	5	8
52	R:R:L228	R:R:V261	30.4824	2.98	Yes	No	0	5	8
53	L:L:F6	R:R:K305	20.2131	4.96	Yes	Yes	1	0	4
54	R:R:V257	R:R:V261	23.9223	1.6	No	No	0	6	8
55	R:R:R253	R:R:V257	22.2631	1.31	No	No	0	3	6
56	R:R:Q248	R:R:R253	20.5962	1.17	No	No	0	4	3
57	R:R:L245	R:R:Q248	15.5497	2.66	No	No	0	3	4
58	R:R:L322	R:R:V268	10.4341	4.47	No	No	0	8	8
59	R:R:V268	R:R:Y323	12.147	6.31	No	Yes	0	8	9
60	R:R:F282	R:R:K305	11.5301	19.85	Yes	Yes	1	5	4
61	R:R:H295	R:R:R297	12.4689	11.28	No	No	0	3	2
62	L:L:F6	R:R:R297	14.22	3.21	Yes	No	0	0	2
63	L:L:?9	L:L:W10	38.7937	12.65	Yes	Yes	1	0	0
64	L:L:W10	R:R:V126	43.3843	15.94	Yes	No	0	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F49	R:R:V45	7.87	1	Yes	No	7	5	2	2
R:R:L102	R:R:V45	13.41	1	Yes	No	5	5	1	2
R:R:L102	R:R:P46	3.28	1	Yes	No	5	6	1	2
R:R:F49	R:R:L102	3.65	1	Yes	Yes	7	5	2	1
R:R:F49	R:R:Y313	7.22	1	Yes	Yes	7	7	2	2
R:R:C95	R:R:F91	4.19	1	Yes	No	7	7	1	2
R:R:C95	R:R:Q122	6.1	1	Yes	No	7	6	1	1
R:R:C95	R:R:Y313	6.72	1	Yes	Yes	7	7	1	2
L:L:?11	R:R:C95	3.93	1	Yes	Yes	0	7	0	1
R:R:P97	R:R:V118	3.53	0	No	No	9	5	2	1
R:R:F98	R:R:L101	4.87	1	Yes	Yes	6	4	1	1
R:R:F98	R:R:L102	7.31	1	Yes	Yes	6	5	1	1
R:R:F98	R:R:H309	14.71	1	Yes	Yes	6	6	1	1
R:R:F98	R:R:Y313	4.13	1	Yes	Yes	6	7	1	2
L:L:L8	R:R:F98	3.65	1	Yes	Yes	0	6	0	1
R:R:L101	R:R:W108	4.56	1	Yes	Yes	4	8	1	2
L:L:N4	R:R:L101	8.24	0	No	Yes	0	4	0	1
L:L:L8	R:R:L101	5.54	1	Yes	Yes	0	4	0	1
L:L:T5	R:R:L102	7.37	0	No	Yes	0	5	0	1
L:L:N4	R:R:G107	5.09	0	No	No	0	5	0	1
R:R:C115	R:R:W108	3.92	1	No	Yes	9	8	2	2
R:R:C191	R:R:W108	11.75	1	No	Yes	9	8	1	2
R:R:C115	R:R:C191	5.46	1	No	No	9	9	2	1
L:L:L8	R:R:V118	5.96	1	Yes	No	0	5	0	1
R:R:H181	R:R:N119	25.51	1	No	No	5	5	1	1
L:L:L8	R:R:N119	8.24	1	Yes	No	0	5	0	1
L:L:?9	R:R:N119	4.36	1	Yes	No	0	5	0	1
L:L:L8	R:R:Q122	7.99	1	Yes	No	0	6	0	1
L:L:?11	R:R:Q122	9.88	1	Yes	No	0	6	0	1
R:R:Q123	R:R:Q127	5.12	1	Yes	Yes	4	6	1	2
R:R:Q123	R:R:V177	5.73	1	Yes	No	4	5	1	2
R:R:F204	R:R:Q123	4.68	1	No	Yes	5	4	1	1
R:R:N208	R:R:Q123	5.28	1	Yes	Yes	5	4	1	1
L:L:W10	R:R:Q123	9.86	1	Yes	Yes	0	4	0	1
R:R:V126	R:R:W276	4.9	0	No	Yes	7	8	1	2
L:L:W10	R:R:V126	15.94	1	Yes	No	0	7	0	1
R:R:L212	R:R:Q127	6.65	1	Yes	Yes	6	6	2	2
R:R:F195	R:R:L180	7.31	1	Yes	Yes	6	4	1	1
L:L:?9	R:R:L180	3.29	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:H181	12.24	1	Yes	No	0	5	0	1
R:R:S184	R:R:Y190	3.82	0	No	No	3	4	2	1
L:L:?3	R:R:Y190	24.65	1	Yes	No	0	4	0	1
L:L:N4	R:R:Y190	5.81	0	No	No	0	4	0	1
L:L:?7	R:R:C191	4.6	0	No	No	0	9	0	1
R:R:E193	R:R:F195	4.66	0	No	Yes	4	6	2	1
R:R:E201	R:R:F195	13.99	0	No	Yes	4	6	2	1
R:R:F195	R:R:F204	7.5	1	Yes	No	6	5	1	1
L:L:?9	R:R:F195	6.76	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F204	14.49	1	Yes	No	0	5	0	1
R:R:L212	R:R:N208	9.61	1	Yes	Yes	6	5	2	1
R:R:N208	R:R:Q280	6.6	1	Yes	Yes	5	7	1	1
R:R:L283	R:R:N208	5.49	0	No	Yes	5	5	2	1
L:L:W10	R:R:N208	7.91	1	Yes	Yes	0	5	0	1
R:R:L209	R:R:Y213	3.52	1	No	Yes	5	8	2	2
R:R:L209	R:R:Q280	5.32	1	No	Yes	5	7	2	1
R:R:L212	R:R:Q280	3.99	1	Yes	Yes	6	7	2	1
R:R:Q280	R:R:Y213	6.76	1	Yes	Yes	7	8	1	2
R:R:A308	R:R:I279	4.87	0	No	No	6	7	2	1
L:L:W10	R:R:I279	8.22	1	Yes	No	0	7	0	1
L:L:W10	R:R:Q280	4.38	1	Yes	Yes	0	7	0	1
R:R:F282	R:R:Q286	5.86	1	Yes	No	5	4	1	1
R:R:F282	R:R:K305	19.85	1	Yes	Yes	5	4	1	1
L:L:F6	R:R:F282	4.29	1	Yes	Yes	0	5	0	1
L:L:F6	R:R:Q286	7.03	1	Yes	No	0	4	0	1
R:R:H295	R:R:R297	11.28	0	No	No	3	2	2	1
L:L:F6	R:R:R297	3.21	1	Yes	No	0	2	0	1
R:R:Y299	R:R:Y302	7.94	0	No	No	4	5	1	1
L:L:?2	R:R:Y299	5.63	1	No	No	0	4	0	1
R:R:T306	R:R:Y302	6.24	0	No	No	4	5	2	1
L:L:T5	R:R:Y302	7.49	0	No	No	0	5	0	1
R:R:H309	R:R:K305	11.79	1	Yes	Yes	6	4	1	1
L:L:F6	R:R:K305	4.96	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:K305	3.36	1	Yes	Yes	0	4	0	1
R:R:H309	R:R:Y313	5.44	1	Yes	Yes	6	7	1	2
L:L:?11	R:R:H309	6.36	1	Yes	Yes	0	6	0	1
R:R:Q123	R:R:S174	2.89	1	Yes	Yes	4	7	1	2
R:R:Q127	R:R:S174	2.89	1	Yes	Yes	6	7	2	2
R:R:F282	R:R:L304	2.44	1	Yes	No	5	6	1	2
R:R:L180	R:R:P176	1.64	1	Yes	No	4	6	1	2
R:R:A179	R:R:L180	1.58	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZJE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	262
Number of Links	304
Number of Hubs	41
Number of Links mediated by Hubs	149
Number of Communities	5
Number of Nodes involved in Communities	56
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	56231
Length Of Smallest Path	3
Average Path Length	13.3264
Length of Longest Path	27
Minimum Path Strength	1.07
Average Path Strength	6.45886
Maximum Path Strength	24.465
Minimum Path Correlation	0.7
Average Path Correlation	0.937512
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	59.4797
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.1619
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACY
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACY
Name	Acetic acid
Synonyms	Acetic acid, glacial
Identifier
Formula	C2 H4 O2
Molecular Weight	60.052
SMILES
PubChem	176
Formal Charge	0
Total Atoms	8
Total Chiral Atoms	0
Total Bonds	7
Total Aromatic Bonds	0


Code	DTY
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTY
Name	D-Tyrosine
Synonyms	(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid (R)-3-(p-Hydroxyphenyl)alanine D-Tyr D-Tyrosin D-Tyrosine
Identifier
Formula	C9 H11 N O3
Molecular Weight	181.189
SMILES
PubChem	71098
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


Code	HYP
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	HYP
Name	Hydroxyproline
Synonyms	HYDROXYPROLINE
Identifier
Formula	C5 H9 N O3
Molecular Weight	131.13
SMILES
PubChem	5810
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	18
Total Aromatic Bonds	0


Code	XZA
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	XZA
Name	diazanecarboxylic acid
Synonyms
Identifier
Formula	C H4 N2 O2
Molecular Weight	76.055
SMILES
PubChem	129728243
Formal Charge	0
Total Atoms	9
Total Chiral Atoms	0
Total Bonds	8
Total Aromatic Bonds	0


Code	NMM
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NMM
Name	Tilarginine
Synonyms	L-Ng-monomethyl Arginine
Identifier
Formula	C7 H16 N4 O2
Molecular Weight	188.228
SMILES
PubChem	46906075
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969F8
Sequence	>8ZJE_nogp_Chain_R A W L V P L F F A A L M L L G L V G N S L V I Y V I C M R T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y P L P G W V L G D F M C K F V N Y I Q Q V S V Q A T C W T L T A M S V D R W Y V T V F P L R A L H R R T P R L A L A V S L S I W V G S A A V S A P V L A L H R L S P Y C S E A F P S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G P W H P R S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R Q A F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZJD	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-	chim(NtGi1-Gq)/β1/γ1	3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJD (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-		3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-	chim(NtGi1-Gq)/β1/γ1	3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-		3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8XGO	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ2	2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-	chim(NtGi1-Gq)/β1/γ2	2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-		2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	Gi1/β1/γ2	3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3	2024-10-30	doi.org/10.1126/sciadv.adn7771

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