psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L47	R:R:W43	4.56	No	No	0	6	2
2	R:R:F49	R:R:V45	7.87	Yes	No	1	7	5
3	R:R:L102	R:R:V45	13.41	Yes	No	1	5	5
4	R:R:L102	R:R:P46	3.28	Yes	No	0	5	6
5	R:R:F49	R:R:L102	3.65	Yes	Yes	1	7	5
6	R:R:C310	R:R:F49	5.59	No	Yes	0	5	7
7	R:R:F49	R:R:Y313	7.22	Yes	Yes	1	7	7
8	R:R:L52	R:R:Y313	3.52	No	Yes	0	7	7
9	R:R:L57	R:R:M53	5.65	No	No	0	6	7
10	R:R:L92	R:R:M53	5.65	No	No	0	7	7
11	R:R:M53	R:R:V96	4.56	No	No	0	7	8
12	R:R:G59	R:R:V58	3.68	No	No	0	8	4
13	R:R:A85	R:R:N60	4.69	No	No	0	9	9
14	R:R:D88	R:R:N60	6.73	Yes	No	0	9	9
15	R:R:N60	R:R:P320	6.52	No	No	0	9	9
16	R:R:A85	R:R:V63	3.39	No	No	0	9	9
17	R:R:F330	R:R:V63	3.93	Yes	No	0	8	9
18	R:R:A85	R:R:I64	3.25	No	No	0	9	7
19	R:R:F330	R:R:V66	6.55	Yes	No	0	8	7
20	R:R:I67	R:R:N78	5.66	No	No	0	7	8
21	R:R:A82	R:R:I67	3.25	No	No	0	6	7
22	R:R:F330	R:R:I67	3.77	Yes	No	0	8	7
23	R:R:M73	R:R:N78	7.01	Yes	No	0	7	8
24	R:R:A333	R:R:M73	3.22	No	Yes	0	6	7
25	R:R:M73	R:R:R336	3.72	Yes	No	0	7	5
26	R:R:F79	R:R:R74	10.69	Yes	No	0	6	7
27	R:R:P156	R:R:R74	4.32	No	No	0	1	7
28	R:R:N78	R:R:T75	4.39	No	No	0	8	7
29	R:R:R154	R:R:V76	10.46	Yes	No	0	7	6
30	R:R:P156	R:R:V76	5.3	No	No	0	1	6
31	R:R:R154	R:R:T77	7.76	Yes	No	0	7	8
32	R:R:A159	R:R:F79	4.16	No	Yes	0	7	6
33	R:R:D139	R:R:Y80	13.79	No	No	0	8	7
34	R:R:A159	R:R:Y80	5.34	No	No	0	7	7
35	R:R:V162	R:R:Y80	3.79	No	No	0	5	7
36	R:R:N83	R:R:S163	8.94	No	No	0	9	8
37	R:R:D88	R:R:L84	8.14	Yes	Yes	0	9	9
38	R:R:L84	R:R:T132	4.42	Yes	No	0	9	8
39	R:R:L133	R:R:L84	5.54	No	Yes	2	8	9
40	R:R:L84	R:R:M136	5.65	Yes	No	2	9	9
41	R:R:L84	R:R:Y323	7.03	Yes	Yes	2	9	9
42	R:R:D88	R:R:T87	4.34	Yes	Yes	0	9	8
43	R:R:T132	R:R:T87	10.99	No	Yes	0	8	8
44	R:R:T87	R:R:W167	4.85	Yes	No	0	8	9
45	R:R:D88	R:R:T129	4.34	Yes	No	0	9	9
46	R:R:D88	R:R:N319	9.42	Yes	Yes	0	9	9
47	R:R:C95	R:R:F91	4.19	Yes	No	0	7	7
48	R:R:F91	R:R:S125	5.28	No	No	0	7	8
49	R:R:F91	R:R:S316	7.93	No	No	0	7	9
50	R:R:L92	R:R:S316	6.01	No	No	0	7	9
51	R:R:C94	R:R:I121	6.55	No	No	0	4	5
52	R:R:C94	R:R:S125	5.16	No	No	0	4	8
53	R:R:C95	R:R:Q122	6.1	Yes	No	1	7	6
54	R:R:C95	R:R:Y313	6.72	Yes	Yes	1	7	7
55	L:L:?11	R:R:C95	3.93	Yes	Yes	1	0	7
56	R:R:P97	R:R:V96	3.53	No	No	0	9	8
57	R:R:P97	R:R:V118	3.53	No	No	0	9	5
58	R:R:F98	R:R:L101	4.87	Yes	Yes	1	6	4
59	R:R:F98	R:R:L102	7.31	Yes	Yes	1	6	5
60	R:R:F98	R:R:H309	14.71	Yes	Yes	1	6	6
61	R:R:F98	R:R:Y313	4.13	Yes	Yes	1	6	7
62	L:L:L8	R:R:F98	3.65	Yes	Yes	1	0	6
63	R:R:L101	R:R:W108	4.56	Yes	Yes	1	4	8
64	L:L:N4	R:R:L101	8.24	No	Yes	0	0	4
65	L:L:L8	R:R:L101	5.54	Yes	Yes	1	0	4
66	L:L:T5	R:R:L102	7.37	No	Yes	0	0	5
67	R:R:P104	R:R:Y103	12.52	No	No	0	5	5
68	R:R:L105	R:R:Y103	10.55	No	No	0	4	5
69	R:R:L105	R:R:P106	3.28	No	No	0	4	5
70	R:R:L105	R:R:V109	7.45	No	No	0	4	3
71	L:L:N4	R:R:G107	5.09	No	No	0	0	5
72	R:R:L110	R:R:W108	10.25	No	Yes	0	7	8
73	R:R:C115	R:R:W108	3.92	No	Yes	1	9	8
74	R:R:L183	R:R:W108	5.69	No	Yes	0	3	8
75	R:R:C191	R:R:W108	11.75	No	Yes	1	9	8
76	R:R:L110	R:R:M114	5.65	No	No	0	7	6
77	R:R:D112	R:R:K116	11.06	No	No	0	3	7
78	R:R:D112	R:R:L183	6.79	No	No	0	3	3
79	R:R:C115	R:R:C191	5.46	No	No	1	9	9
80	L:L:L8	R:R:V118	5.96	Yes	No	0	0	5
81	R:R:H181	R:R:N119	25.51	No	No	1	5	5
82	L:L:L8	R:R:N119	8.24	Yes	No	1	0	5
83	L:L:?9	R:R:N119	4.36	Yes	No	1	0	5
84	R:R:V124	R:R:Y120	6.31	No	Yes	1	5	6
85	R:R:S174	R:R:Y120	8.9	Yes	Yes	1	7	6
86	R:R:L178	R:R:Y120	15.24	No	Yes	0	5	6
87	L:L:L8	R:R:Q122	7.99	Yes	No	1	0	6
88	L:L:?11	R:R:Q122	9.88	Yes	No	1	0	6
89	R:R:Q123	R:R:Q127	5.12	Yes	Yes	1	4	6
90	R:R:Q123	R:R:V177	5.73	Yes	No	0	4	5
91	R:R:F204	R:R:Q123	4.68	No	Yes	1	5	4
92	R:R:N208	R:R:Q123	5.28	Yes	Yes	1	5	4
93	L:L:W10	R:R:Q123	9.86	Yes	Yes	1	0	4
94	R:R:S170	R:R:V124	6.46	No	No	0	7	5
95	R:R:S174	R:R:V124	4.85	Yes	No	1	7	5
96	R:R:V126	R:R:W276	4.9	No	Yes	0	7	8
97	L:L:W10	R:R:V126	15.94	Yes	No	0	0	7
98	R:R:Q127	R:R:W131	16.43	Yes	No	0	6	6
99	R:R:Q127	R:R:Y207	5.64	Yes	No	0	6	4
100	R:R:L212	R:R:Q127	6.65	Yes	Yes	1	6	6
101	R:R:A128	R:R:W167	7.78	No	No	0	7	9
102	R:R:C130	R:R:L212	4.76	No	Yes	0	7	6
103	R:R:L133	R:R:N319	5.49	No	Yes	2	8	9
104	R:R:L133	R:R:Y323	4.69	No	Yes	2	8	9
105	R:R:P216	R:R:T134	3.5	No	No	0	9	7
106	R:R:M136	R:R:Y323	4.79	No	Yes	2	9	9
107	R:R:S137	R:R:T220	9.59	No	No	4	9	8
108	R:R:C223	R:R:S137	5.16	No	No	0	7	9
109	R:R:S137	R:R:Y224	5.09	No	Yes	4	9	9
110	R:R:C223	R:R:V138	3.42	No	No	0	7	7
111	R:R:D139	R:R:R154	11.91	No	Yes	0	8	7
112	R:R:R140	R:R:Y224	10.29	No	Yes	0	9	9
113	R:R:R140	R:R:Y323	7.2	No	Yes	0	9	9
114	R:R:V145	R:R:W141	8.58	No	No	0	7	8
115	R:R:F146	R:R:Y142	7.22	Yes	Yes	3	6	4
116	R:R:R149	R:R:Y142	5.14	No	Yes	3	5	4
117	R:R:R153	R:R:Y142	6.17	No	Yes	3	4	4
118	R:R:R154	R:R:V143	6.54	Yes	No	0	7	8
119	R:R:M227	R:R:T144	9.03	No	No	0	9	8
120	R:R:L231	R:R:T144	4.42	No	No	0	8	8
121	R:R:F146	R:R:V145	9.18	Yes	No	0	6	7
122	R:R:H230	R:R:V145	5.54	No	No	0	5	7
123	R:R:F146	R:R:R149	5.34	Yes	No	3	6	5
124	R:R:R149	R:R:R153	5.33	No	No	3	5	4
125	R:R:P156	R:R:T155	3.5	No	No	0	1	7
126	R:R:V173	R:R:Y207	3.79	No	No	0	5	4
127	R:R:F195	R:R:L180	7.31	Yes	Yes	1	6	4
128	L:L:?9	R:R:L180	3.29	Yes	Yes	1	0	4
129	L:L:?9	R:R:H181	12.24	Yes	No	1	0	5
130	R:R:A194	R:R:R182	6.91	No	No	0	3	5
131	R:R:S184	R:R:Y190	3.82	No	No	0	3	4
132	R:R:S184	R:R:S192	6.52	No	No	0	3	4
133	L:L:?3	R:R:Y190	24.65	Yes	No	0	0	4
134	L:L:N4	R:R:Y190	5.81	No	No	0	0	4
135	L:L:?7	R:R:C191	4.6	No	No	0	0	9
136	R:R:E193	R:R:F195	4.66	No	Yes	0	4	6
137	R:R:E201	R:R:F195	13.99	No	Yes	0	4	6
138	R:R:F195	R:R:F204	7.5	Yes	No	1	6	5
139	L:L:?9	R:R:F195	6.76	Yes	Yes	1	0	6
140	R:R:L200	R:R:P196	6.57	No	No	0	3	4
141	R:R:L200	R:R:S197	4.5	No	No	0	3	3
142	R:R:E201	R:R:R198	9.3	No	No	0	4	1
143	R:R:R198	R:R:R202	4.26	No	No	0	1	1
144	L:L:?9	R:R:F204	14.49	Yes	No	1	0	5
145	R:R:A211	R:R:Y207	5.34	No	No	0	4	4
146	R:R:L212	R:R:N208	9.61	Yes	Yes	1	6	5
147	R:R:N208	R:R:Q280	6.6	Yes	Yes	1	5	7
148	R:R:L283	R:R:N208	5.49	No	Yes	0	5	5
149	L:L:W10	R:R:N208	7.91	Yes	Yes	1	0	5
150	R:R:L209	R:R:Y213	3.52	No	Yes	1	5	8
151	R:R:L209	R:R:Q280	5.32	No	Yes	1	5	7
152	R:R:L212	R:R:Q280	3.99	Yes	Yes	1	6	7
153	R:R:L217	R:R:Y213	3.52	Yes	Yes	0	6	8
154	R:R:G277	R:R:Y213	5.79	No	Yes	0	6	8
155	R:R:Q280	R:R:Y213	6.76	Yes	Yes	1	7	8
156	R:R:F272	R:R:L217	3.65	No	Yes	0	9	6
157	R:R:T220	R:R:Y224	3.75	No	Yes	4	8	9
158	R:R:V265	R:R:Y224	17.66	No	Yes	0	8	9
159	R:R:L228	R:R:S262	4.5	Yes	No	0	5	7
160	R:R:L231	R:R:V261	4.47	No	No	0	8	8
161	R:R:P240	R:R:V249	3.53	No	No	0	4	2
162	R:R:D242	R:R:L245	4.07	No	No	0	4	3
163	R:R:E252	R:R:Q248	5.1	No	No	0	3	4
164	R:R:L250	R:R:V249	4.47	No	No	0	3	2
165	R:R:A251	R:R:E252	4.53	No	No	0	1	3
166	R:R:L322	R:R:V268	4.47	No	No	0	8	8
167	R:R:V268	R:R:Y323	6.31	No	Yes	0	8	9
168	R:R:L271	R:R:L318	5.54	No	No	0	7	6
169	R:R:L271	R:R:L322	5.54	No	No	0	7	8
170	R:R:F272	R:R:W276	8.02	No	Yes	0	9	8
171	R:R:C275	R:R:N315	4.72	No	No	0	9	9
172	R:R:S312	R:R:W276	3.71	No	Yes	0	7	8
173	R:R:N315	R:R:W276	12.43	No	Yes	0	9	8
174	R:R:G277	R:R:P278	4.06	No	No	0	6	9
175	R:R:P278	R:R:W307	6.76	No	No	5	9	5
176	R:R:M311	R:R:P278	3.35	No	No	5	7	9
177	R:R:A308	R:R:I279	4.87	No	No	0	6	7
178	L:L:W10	R:R:I279	8.22	Yes	No	0	0	7
179	L:L:W10	R:R:Q280	4.38	Yes	Yes	1	0	7
180	R:R:L281	R:R:L285	5.54	No	No	1	6	6
181	R:R:F282	R:R:Q286	5.86	Yes	No	1	5	4
182	R:R:F282	R:R:K305	19.85	Yes	Yes	1	5	4
183	L:L:F6	R:R:F282	4.29	Yes	Yes	1	0	5
184	R:R:L285	R:R:W294	10.25	No	No	0	6	1
185	L:L:F6	R:R:Q286	7.03	Yes	No	1	0	4
186	R:R:G289	R:R:P290	4.06	No	No	0	3	1
187	R:R:G289	R:R:P296	4.06	No	No	0	3	3
188	R:R:A301	R:R:W294	3.89	No	No	0	6	1
189	R:R:H295	R:R:P296	4.58	No	No	0	3	3
190	R:R:H295	R:R:R297	11.28	No	No	0	3	2
191	L:L:F6	R:R:R297	3.21	Yes	No	0	0	2
192	R:R:Y299	R:R:Y302	7.94	No	No	0	4	5
193	L:L:?2	R:R:Y299	5.63	No	No	0	0	4
194	R:R:T306	R:R:Y302	6.24	No	No	0	4	5
195	L:L:T5	R:R:Y302	7.49	No	No	0	0	5
196	R:R:H309	R:R:K305	11.79	Yes	Yes	1	6	4
197	L:L:F6	R:R:K305	4.96	Yes	Yes	1	0	4
198	L:L:?9	R:R:K305	3.36	Yes	Yes	1	0	4
199	R:R:M311	R:R:W307	5.82	No	No	5	7	5
200	R:R:H309	R:R:Y313	5.44	Yes	Yes	1	6	7
201	L:L:?11	R:R:H309	6.36	Yes	Yes	1	0	6
202	R:R:S312	R:R:Y313	5.09	No	Yes	0	7	7
203	R:R:N315	R:R:N319	9.54	No	Yes	0	9	9
204	R:R:N319	R:R:Y323	4.65	Yes	Yes	2	9	9
205	R:R:L321	R:R:L326	4.15	No	No	0	7	7
206	R:R:A324	R:R:F330	8.32	No	Yes	0	7	8
207	R:R:F325	R:R:F330	8.57	No	Yes	0	6	8
208	L:L:?1	L:L:?2	24.2	No	No	1	0	0
209	L:L:?1	L:L:?3	3.25	No	Yes	1	0	0
210	L:L:?1	L:L:T5	5.69	No	No	0	0	0
211	L:L:?2	L:L:?3	24.28	No	Yes	1	0	0
212	L:L:?3	L:L:F6	3.34	Yes	Yes	1	0	0
213	L:L:?3	L:L:?7	3.67	Yes	No	0	0	0
214	L:L:?7	L:L:L8	5.35	No	Yes	0	0	0
215	L:L:?9	L:L:L8	3.29	Yes	Yes	1	0	0
216	L:L:?9	L:L:W10	12.65	Yes	Yes	1	0	0
217	L:L:?11	L:L:W10	8.46	Yes	Yes	1	0	0
218	R:R:C221	R:R:L217	3.17	No	Yes	0	5	6
219	R:R:T220	R:R:V269	3.17	No	No	0	8	8
220	R:R:A273	R:R:L217	3.15	No	Yes	0	5	6
221	R:R:L57	R:R:S61	3	No	No	0	6	4
222	R:R:G232	R:R:R258	3	No	No	0	5	7
223	R:R:L57	R:R:V89	2.98	No	No	0	6	7
224	R:R:L62	R:R:V58	2.98	No	No	0	6	4
225	R:R:L93	R:R:V89	2.98	No	No	0	5	7
226	R:R:L110	R:R:V109	2.98	No	No	0	7	3
227	R:R:L209	R:R:V284	2.98	No	No	0	5	5
228	R:R:L228	R:R:V261	2.98	Yes	No	0	5	8
229	R:R:L228	R:R:V265	2.98	Yes	No	0	5	8
230	R:R:D242	R:R:S243	2.94	No	No	0	4	4
231	R:R:N83	R:R:T87	2.92	No	Yes	0	9	8
232	R:R:Q123	R:R:S174	2.89	Yes	Yes	1	4	7
233	R:R:Q127	R:R:S170	2.89	Yes	No	0	6	7
234	R:R:Q127	R:R:S174	2.89	Yes	Yes	1	6	7
235	R:R:L44	R:R:L47	2.77	No	No	0	5	6
236	R:R:L148	R:R:L151	2.77	No	No	0	6	4
237	R:R:L160	R:R:L164	2.77	No	No	0	3	4
238	R:R:A199	R:R:R202	2.77	No	No	0	1	1
239	R:R:L210	R:R:L215	2.77	No	No	0	5	6
240	R:R:H230	R:R:V234	2.77	No	No	0	5	6
241	R:R:L264	R:R:L326	2.77	No	No	0	8	7
242	R:R:L322	R:R:L326	2.77	No	No	0	8	7
243	R:R:P216	R:R:W131	2.7	No	No	0	9	6
244	R:R:L245	R:R:Q248	2.66	No	No	0	3	4
245	R:R:H329	R:R:M73	2.63	No	Yes	0	6	7
246	R:R:A226	R:R:W141	2.59	No	No	0	5	8
247	R:R:R157	R:R:T155	2.59	No	No	0	4	7
248	R:R:F325	R:R:L62	2.44	No	No	0	6	6
249	R:R:F79	R:R:L160	2.44	Yes	No	0	6	3
250	R:R:F282	R:R:L304	2.44	Yes	No	1	5	6
251	R:R:T90	R:R:W167	2.43	No	No	0	6	9
252	R:R:F79	R:R:N83	2.42	Yes	No	0	6	9
253	R:R:I166	R:R:W131	2.35	No	No	0	7	6
254	R:R:L214	R:R:Y213	2.34	No	Yes	0	4	8
255	R:R:H152	R:R:R153	2.26	No	No	0	5	4
256	R:R:F113	R:R:F117	2.14	No	No	0	3	5
257	R:R:R154	R:R:Y142	2.06	Yes	Yes	0	7	4
258	R:R:A317	R:R:G56	1.95	No	No	0	7	8
259	R:R:A172	R:R:G169	1.95	No	No	0	4	4
260	R:R:A175	R:R:P176	1.87	No	No	0	5	6
261	R:R:A205	R:R:A287	1.79	No	No	0	5	5
262	R:R:P185	R:R:S184	1.78	No	No	0	2	3
263	R:R:P46	R:R:T99	1.75	No	No	0	6	6
264	R:R:G111	R:R:M114	1.75	No	No	0	8	6
265	R:R:C275	R:R:S314	1.72	No	No	0	9	5
266	R:R:G56	R:R:L55	1.71	No	No	0	8	6
267	R:R:G56	R:R:L92	1.71	No	No	0	8	7
268	R:R:A171	R:R:S170	1.71	No	No	0	4	7
269	R:R:A199	R:R:S197	1.71	No	No	0	1	3
270	R:R:G289	R:R:L288	1.71	No	No	0	3	4
271	R:R:A300	R:R:S298	1.71	No	No	0	3	4
272	R:R:A135	R:R:V162	1.7	No	No	0	7	5
273	R:R:A150	R:R:V143	1.7	No	No	0	6	8
274	R:R:A219	R:R:T134	1.68	No	No	0	6	7
275	R:R:A303	R:R:T306	1.68	No	No	0	2	4
276	R:R:C68	R:R:I64	1.64	No	No	0	4	7
277	R:R:L180	R:R:P176	1.64	Yes	No	0	4	6
278	R:R:L215	R:R:P216	1.64	No	No	0	6	9
279	R:R:L245	R:R:P240	1.64	No	No	0	3	4
280	R:R:G247	R:R:Q246	1.64	No	No	0	4	4
281	R:R:V257	R:R:V261	1.6	No	No	0	6	8
282	R:R:A179	R:R:L180	1.58	No	Yes	0	4	4
283	R:R:P240	R:R:Q246	1.58	No	No	0	4	4
284	R:R:I81	R:R:V63	1.54	No	No	0	8	9
285	R:R:A244	R:R:D242	1.54	No	No	0	4	4
286	R:R:L158	R:R:V162	1.49	No	No	0	4	5
287	R:R:F146	R:R:P147	1.44	Yes	No	0	6	8
288	R:R:H295	R:R:S298	1.39	No	No	0	3	4
289	R:R:L206	R:R:L210	1.38	No	No	0	5	5
290	R:R:L281	R:R:L304	1.38	No	No	1	6	6
291	R:R:L285	R:R:L304	1.38	No	No	1	6	6
292	R:R:R263	R:R:S262	1.32	No	No	0	7	7
293	R:R:F334	R:R:V66	1.31	No	No	0	6	7
294	R:R:R253	R:R:V257	1.31	No	No	0	3	6
295	R:R:H152	R:R:L151	1.29	No	No	0	5	4
296	R:R:K116	R:R:R182	1.24	No	No	0	7	5
297	R:R:F48	R:R:L44	1.22	No	No	0	4	5
298	R:R:F48	R:R:L52	1.22	No	No	0	4	7
299	R:R:L228	R:R:R258	1.21	Yes	No	0	5	7
300	R:R:Q248	R:R:R253	1.17	No	No	0	4	3
301	R:R:Q332	R:R:R335	1.17	No	No	0	5	4
302	R:R:R331	R:R:R335	1.07	No	No	0	8	4
303	R:R:F334	R:R:R335	1.07	No	No	0	6	4
304	R:R:F117	R:R:Y120	1.03	No	Yes	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F49	6.0825	4	1	7
2	R:R:M73	4.145	4	0	7
3	R:R:F79	4.9275	4	0	6
4	R:R:L84	6.156	5	2	9
5	R:R:T87	5.775	4	0	8
6	R:R:D88	6.594	5	0	9
7	R:R:C95	5.235	4	1	7
8	R:R:F98	6.934	5	1	6
9	R:R:L101	5.8025	4	1	4
10	R:R:L102	7.004	5	1	5
11	R:R:W108	7.234	5	1	8
12	R:R:Y120	7.87	4	1	6
13	R:R:Q123	5.59333	6	1	4
14	R:R:Q127	6.60333	6	1	6
15	R:R:Y142	5.1475	4	3	4
16	R:R:F146	5.795	4	3	6
17	R:R:R154	7.746	5	0	7
18	R:R:S174	4.8825	4	1	7
19	R:R:L180	3.455	4	1	4
20	R:R:F195	8.044	5	1	6
21	R:R:N208	6.978	5	1	5
22	R:R:L212	6.2525	4	1	6
23	R:R:Y213	4.386	5	1	8
24	R:R:L217	3.3725	4	0	6
25	R:R:Y224	9.1975	4	4	9
26	R:R:L228	2.9175	4	0	5
27	R:R:W276	7.265	4	0	8
28	R:R:Q280	5.41	5	1	7
29	R:R:F282	8.11	4	1	5
30	R:R:K305	9.99	4	1	4
31	R:R:H309	9.575	4	1	6
32	R:R:Y313	5.35333	6	1	7
33	R:R:N319	7.275	4	2	9
34	R:R:Y323	5.77833	6	2	9
35	R:R:F330	6.228	5	0	8
36	L:L:?3	11.838	5	1	0
37	L:L:F6	4.566	5	1	0
38	L:L:L8	5.71714	7	1	0
39	L:L:?9	7.555	8	1	0
40	L:L:W10	9.63143	7	1	0
41	L:L:?11	7.1575	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F98	R:R:L102	11.4189	7.31	Yes	Yes	1	6	5
2	R:R:F98	R:R:Y313	25.4512	4.13	Yes	Yes	1	6	7
3	R:R:C95	R:R:Y313	12.8329	6.72	Yes	Yes	1	7	7
4	R:R:C95	R:R:F91	15.6915	4.19	Yes	No	0	7	7
5	R:R:F91	R:R:S316	10.5721	7.93	No	No	0	7	9
6	R:R:F330	R:R:V63	25.1868	3.93	Yes	No	0	8	9
7	R:R:A85	R:R:V63	27.6775	3.39	No	No	0	9	9
8	R:R:A85	R:R:N60	31.3561	4.69	No	No	0	9	9
9	R:R:D88	R:R:N60	33.7702	6.73	Yes	No	0	9	9
10	R:R:D88	R:R:N319	77.3805	9.42	Yes	Yes	0	9	9
11	R:R:N315	R:R:N319	99.2643	9.54	No	Yes	0	9	9
12	R:R:N315	R:R:W276	100	12.43	No	Yes	0	9	8
13	R:R:S312	R:R:W276	52.8413	3.71	No	Yes	0	7	8
14	R:R:S312	R:R:Y313	52.5923	5.09	No	Yes	0	7	7
15	R:R:F330	R:R:I67	10.94	3.77	Yes	No	0	8	7
16	R:R:F79	R:R:N83	65.8428	2.42	Yes	No	0	6	9
17	R:R:N83	R:R:T87	68.2032	2.92	No	Yes	0	9	8
18	R:R:D88	R:R:T87	64.8044	4.34	Yes	Yes	0	9	8
19	R:R:F79	R:R:R74	30.5131	10.69	Yes	No	0	6	7
20	R:R:P156	R:R:R74	29.1911	4.32	No	No	0	1	7
21	R:R:P156	R:R:V76	25.2366	5.3	No	No	0	1	6
22	R:R:R154	R:R:V76	23.9223	10.46	Yes	No	0	7	6
23	R:R:A159	R:R:F79	31.8964	4.16	No	Yes	0	7	6
24	R:R:A159	R:R:Y80	30.5821	5.34	No	No	0	7	7
25	R:R:D139	R:R:Y80	25.3094	13.79	No	No	0	8	7
26	R:R:D139	R:R:R154	23.9874	11.91	No	Yes	0	8	7
27	R:R:D88	R:R:L84	14.8255	8.14	Yes	Yes	0	9	9
28	R:R:N319	R:R:Y323	44.1545	4.65	Yes	Yes	2	9	9
29	R:R:L84	R:R:Y323	22.1443	7.03	Yes	Yes	2	9	9
30	R:R:L84	R:R:T132	11.2427	4.42	Yes	No	0	9	8
31	R:R:H309	R:R:Y313	14.4231	5.44	Yes	Yes	1	6	7
32	R:R:F98	R:R:L101	15.4002	4.87	Yes	Yes	1	6	4
33	R:R:L101	R:R:W108	17.8488	4.56	Yes	Yes	1	4	8
34	L:L:T5	R:R:L102	11.1201	7.37	No	Yes	0	0	5
35	R:R:L110	R:R:W108	10.1123	10.25	No	Yes	0	7	8
36	L:L:?9	L:L:L8	22.6693	3.29	Yes	Yes	1	0	0
37	L:L:?9	R:R:K305	20.2667	3.36	Yes	Yes	1	0	4
38	R:R:H309	R:R:K305	14.1855	11.79	Yes	Yes	1	6	4
39	L:L:W10	R:R:Q123	23.6157	9.86	Yes	Yes	1	0	4
40	R:R:Q123	R:R:Q127	19.987	5.12	Yes	Yes	1	4	6
41	R:R:V126	R:R:W276	43.4494	4.9	No	Yes	0	7	8
42	R:R:Q127	R:R:W131	12.3194	16.43	Yes	No	0	6	6
43	L:L:W10	R:R:Q280	10.1966	4.38	Yes	Yes	1	0	7
44	R:R:R140	R:R:Y323	50.8334	7.2	No	Yes	0	9	9
45	R:R:R140	R:R:Y224	49.3658	10.29	No	Yes	0	9	9
46	R:R:R154	R:R:Y142	36.7092	2.06	Yes	Yes	0	7	4
47	R:R:F146	R:R:Y142	19.8988	7.22	Yes	Yes	3	6	4
48	R:R:F146	R:R:V145	14.3465	9.18	Yes	No	0	6	7
49	R:R:R153	R:R:Y142	11.4151	6.17	No	Yes	3	4	4
50	R:R:V265	R:R:Y224	40.0314	17.66	No	Yes	0	8	9
51	R:R:L228	R:R:V265	38.4489	2.98	Yes	No	0	5	8
52	R:R:L228	R:R:V261	30.4824	2.98	Yes	No	0	5	8
53	L:L:F6	R:R:K305	20.2131	4.96	Yes	Yes	1	0	4
54	R:R:V257	R:R:V261	23.9223	1.6	No	No	0	6	8
55	R:R:R253	R:R:V257	22.2631	1.31	No	No	0	3	6
56	R:R:Q248	R:R:R253	20.5962	1.17	No	No	0	4	3
57	R:R:L245	R:R:Q248	15.5497	2.66	No	No	0	3	4
58	R:R:L322	R:R:V268	10.4341	4.47	No	No	0	8	8
59	R:R:V268	R:R:Y323	12.147	6.31	No	Yes	0	8	9
60	R:R:F282	R:R:K305	11.5301	19.85	Yes	Yes	1	5	4
61	R:R:H295	R:R:R297	12.4689	11.28	No	No	0	3	2
62	L:L:F6	R:R:R297	14.22	3.21	Yes	No	0	0	2
63	L:L:?9	L:L:W10	38.7937	12.65	Yes	Yes	1	0	0
64	L:L:W10	R:R:V126	43.3843	15.94	Yes	No	0	0	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F49	R:R:V45	7.87	1	Yes	No	7	5	2	2
R:R:L102	R:R:V45	13.41	1	Yes	No	5	5	1	2
R:R:L102	R:R:P46	3.28	1	Yes	No	5	6	1	2
R:R:F49	R:R:L102	3.65	1	Yes	Yes	7	5	2	1
R:R:F49	R:R:Y313	7.22	1	Yes	Yes	7	7	2	2
R:R:C95	R:R:F91	4.19	1	Yes	No	7	7	1	2
R:R:C95	R:R:Q122	6.1	1	Yes	No	7	6	1	1
R:R:C95	R:R:Y313	6.72	1	Yes	Yes	7	7	1	2
L:L:?11	R:R:C95	3.93	1	Yes	Yes	0	7	0	1
R:R:P97	R:R:V118	3.53	0	No	No	9	5	2	1
R:R:F98	R:R:L101	4.87	1	Yes	Yes	6	4	1	1
R:R:F98	R:R:L102	7.31	1	Yes	Yes	6	5	1	1
R:R:F98	R:R:H309	14.71	1	Yes	Yes	6	6	1	1
R:R:F98	R:R:Y313	4.13	1	Yes	Yes	6	7	1	2
L:L:L8	R:R:F98	3.65	1	Yes	Yes	0	6	0	1
R:R:L101	R:R:W108	4.56	1	Yes	Yes	4	8	1	2
L:L:N4	R:R:L101	8.24	0	No	Yes	0	4	0	1
L:L:L8	R:R:L101	5.54	1	Yes	Yes	0	4	0	1
L:L:T5	R:R:L102	7.37	0	No	Yes	0	5	0	1
L:L:N4	R:R:G107	5.09	0	No	No	0	5	0	1
R:R:C115	R:R:W108	3.92	1	No	Yes	9	8	2	2
R:R:C191	R:R:W108	11.75	1	No	Yes	9	8	1	2
R:R:C115	R:R:C191	5.46	1	No	No	9	9	2	1
L:L:L8	R:R:V118	5.96	1	Yes	No	0	5	0	1
R:R:H181	R:R:N119	25.51	1	No	No	5	5	1	1
L:L:L8	R:R:N119	8.24	1	Yes	No	0	5	0	1
L:L:?9	R:R:N119	4.36	1	Yes	No	0	5	0	1
L:L:L8	R:R:Q122	7.99	1	Yes	No	0	6	0	1
L:L:?11	R:R:Q122	9.88	1	Yes	No	0	6	0	1
R:R:Q123	R:R:Q127	5.12	1	Yes	Yes	4	6	1	2
R:R:Q123	R:R:V177	5.73	1	Yes	No	4	5	1	2
R:R:F204	R:R:Q123	4.68	1	No	Yes	5	4	1	1
R:R:N208	R:R:Q123	5.28	1	Yes	Yes	5	4	1	1
L:L:W10	R:R:Q123	9.86	1	Yes	Yes	0	4	0	1
R:R:V126	R:R:W276	4.9	0	No	Yes	7	8	1	2
L:L:W10	R:R:V126	15.94	1	Yes	No	0	7	0	1
R:R:L212	R:R:Q127	6.65	1	Yes	Yes	6	6	2	2
R:R:F195	R:R:L180	7.31	1	Yes	Yes	6	4	1	1
L:L:?9	R:R:L180	3.29	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:H181	12.24	1	Yes	No	0	5	0	1
R:R:S184	R:R:Y190	3.82	0	No	No	3	4	2	1
L:L:?3	R:R:Y190	24.65	1	Yes	No	0	4	0	1
L:L:N4	R:R:Y190	5.81	0	No	No	0	4	0	1
L:L:?7	R:R:C191	4.6	0	No	No	0	9	0	1
R:R:E193	R:R:F195	4.66	0	No	Yes	4	6	2	1
R:R:E201	R:R:F195	13.99	0	No	Yes	4	6	2	1
R:R:F195	R:R:F204	7.5	1	Yes	No	6	5	1	1
L:L:?9	R:R:F195	6.76	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F204	14.49	1	Yes	No	0	5	0	1
R:R:L212	R:R:N208	9.61	1	Yes	Yes	6	5	2	1
R:R:N208	R:R:Q280	6.6	1	Yes	Yes	5	7	1	1
R:R:L283	R:R:N208	5.49	0	No	Yes	5	5	2	1
L:L:W10	R:R:N208	7.91	1	Yes	Yes	0	5	0	1
R:R:L209	R:R:Y213	3.52	1	No	Yes	5	8	2	2
R:R:L209	R:R:Q280	5.32	1	No	Yes	5	7	2	1
R:R:L212	R:R:Q280	3.99	1	Yes	Yes	6	7	2	1
R:R:Q280	R:R:Y213	6.76	1	Yes	Yes	7	8	1	2
R:R:A308	R:R:I279	4.87	0	No	No	6	7	2	1
L:L:W10	R:R:I279	8.22	1	Yes	No	0	7	0	1
L:L:W10	R:R:Q280	4.38	1	Yes	Yes	0	7	0	1
R:R:F282	R:R:Q286	5.86	1	Yes	No	5	4	1	1
R:R:F282	R:R:K305	19.85	1	Yes	Yes	5	4	1	1
L:L:F6	R:R:F282	4.29	1	Yes	Yes	0	5	0	1
L:L:F6	R:R:Q286	7.03	1	Yes	No	0	4	0	1
R:R:H295	R:R:R297	11.28	0	No	No	3	2	2	1
L:L:F6	R:R:R297	3.21	1	Yes	No	0	2	0	1
R:R:Y299	R:R:Y302	7.94	0	No	No	4	5	1	1
L:L:?2	R:R:Y299	5.63	1	No	No	0	4	0	1
R:R:T306	R:R:Y302	6.24	0	No	No	4	5	2	1
L:L:T5	R:R:Y302	7.49	0	No	No	0	5	0	1
R:R:H309	R:R:K305	11.79	1	Yes	Yes	6	4	1	1
L:L:F6	R:R:K305	4.96	1	Yes	Yes	0	4	0	1
L:L:?9	R:R:K305	3.36	1	Yes	Yes	0	4	0	1
R:R:H309	R:R:Y313	5.44	1	Yes	Yes	6	7	1	2
L:L:?11	R:R:H309	6.36	1	Yes	Yes	0	6	0	1
R:R:Q123	R:R:S174	2.89	1	Yes	Yes	4	7	1	2
R:R:Q127	R:R:S174	2.89	1	Yes	Yes	6	7	2	2
R:R:F282	R:R:L304	2.44	1	Yes	No	5	6	1	2
R:R:L180	R:R:P176	1.64	1	Yes	No	4	6	1	2
R:R:A179	R:R:L180	1.58	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8ZJE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.21
Number of Linked Nodes	262
Number of Links	304
Number of Hubs	41
Number of Links mediated by Hubs	149
Number of Communities	5
Number of Nodes involved in Communities	56
Number of Links involved in Communities	84

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	56231
Length Of Smallest Path	3
Average Path Length	13.3264
Length of Longest Path	27
Minimum Path Strength	1.07
Average Path Strength	6.45886
Maximum Path Strength	24.465
Minimum Path Correlation	0.7
Average Path Correlation	0.937512
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	59.4797
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.1619
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• GTPase regulator activity • enzyme regulator activity • enzyme activator activity • GTPase activator activity • molecular function activator activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • cation binding • metal ion binding • D2 dopamine receptor binding • dopamine receptor binding • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • G protein-coupled receptor signaling pathway • neuropeptide signaling pathway • multicellular organismal process • regulation of body fluid levels • wound healing • hemostasis • blood coagulation • response to stress • coagulation • regulation of biological quality • response to wounding • regulation of protein stability • protein stabilization • phospholipase C-activating serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • rhythmic process • entrainment of circadian clock • circadian rhythm • response to external stimulus • regulation of circadian rhythm • response to endogenous stimulus • hormone-mediated signaling pathway • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • glutamate receptor signaling pathway • system process • sensory perception • nervous system process • sensory perception of itch • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • establishment of organelle localization • regulated exocytosis • cellular localization • transport • cell activation involved in immune response • leukocyte degranulation • myeloid leukocyte activation • myeloid leukocyte mediated immunity • vesicle-mediated transport • leukocyte activation • localization • secretion by cell • organelle localization • leukocyte activation involved in immune response • establishment of localization in cell • mast cell activation • leukocyte mediated immunity • mast cell mediated immunity • immune response • secretion • cell activation • vacuolar localization • export from cell • mast cell degranulation • establishment of localization • myeloid cell activation involved in immune response • immune effector process • mast cell activation involved in immune response • exocytosis • immune system process • lysosome localization • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • detection of light stimulus • response to light stimulus • phototransduction • detection of external stimulus • detection of visible light • detection of abiotic stimulus • detection of stimulus • response to radiation • phototransduction, visible light • regulation of cell activation • regulation of platelet activation • regulation of multicellular organismal process • platelet activation • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • G protein-coupled glutamate receptor signaling pathway • cellular response to nitrogen compound • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • response to nitrogen compound • acetylcholine receptor signaling pathway • postsynaptic signal transduction • cellular response to oxygen-containing compound • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • adenylate cyclase-inhibiting serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • relaxation of smooth muscle • regulation of system process • regulation of muscle system process • muscle system process • relaxation of muscle • positive regulation of relaxation of smooth muscle • positive regulation of relaxation of muscle • positive regulation of multicellular organismal process • regulation of relaxation of smooth muscle • regulation of relaxation of muscle • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • intracellular anatomical structure • nuclear membrane • nucleus • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • organelle envelope • organelle • nuclear envelope • organelle membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytoplasm • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • Golgi apparatus • postsynapse • synapse • cell junction • postsynaptic cytosol • cytosol • midbody • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • sperm principal piece • 9+2 motile cilium • sperm flagellum • motile cilium • nucleoplasm • ciliary basal body • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • photoreceptor disc membrane • G-protein beta-subunit binding • fibroblast proliferation • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • neuropeptide signaling pathway • positive regulation of cell communication • regulation of localization • regulation of hormone secretion • transport • positive regulation of biological process • positive regulation of secretion by cell • hormone secretion • localization • positive regulation of hormone secretion • regulation of secretion by cell • secretion by cell • positive regulation of secretion • signal release • regulation of biological quality • positive regulation of cellular process • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • export from cell • establishment of localization • regulation of secretion • positive regulation of transport • regulation of cell communication • hormone transport • positive regulation of signaling • cell surface
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACY
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACY
Name	Acetic acid
Synonyms	Ethanoic acid
Identifier
Formula	C2 H4 O2
Molecular Weight	60.052
SMILES
PubChem	176
Formal Charge	0
Total Atoms	8
Total Chiral Atoms	0
Total Bonds	7
Total Aromatic Bonds	0


Code	DTY
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTY
Name	D-Tyrosine
Synonyms	(R)-2-Amino-3-(p-hydroxyphenyl)propionic acid D-Tyrosine D-Tyrosin D-Tyr (R)-3-(p-Hydroxyphenyl)alanine
Identifier
Formula	C9 H11 N O3
Molecular Weight	181.189
SMILES
PubChem	71098
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


Code	HYP
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	HYP
Name	Hydroxyproline
Synonyms	HYDROXYPROLINE
Identifier
Formula	C5 H9 N O3
Molecular Weight	131.13
SMILES
PubChem	6971053
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	18
Total Aromatic Bonds	0


Code	XZA
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	XZA
Name	diazanecarboxylic acid
Synonyms
Identifier
Formula	C H4 N2 O2
Molecular Weight	76.055
SMILES
PubChem	129728243
Formal Charge	0
Total Atoms	9
Total Chiral Atoms	0
Total Bonds	8
Total Aromatic Bonds	0


Code	NMM
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NMM
Name	Tilarginine
Synonyms	N-Methylarginine
Identifier
Formula	C7 H16 N4 O2
Molecular Weight	188.228
SMILES
PubChem	46906075
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969F8
Sequence	>8ZJE_nogp_Chain_R A W L V P L F F A A L M L L G L V G N S L V I Y V I C M R T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y P L P G W V L G D F M C K F V N Y I Q Q V S V Q A T C W T L T A M S V D R W Y V T V F P L R A L H R R T P R L A L A V S L S I W V G S A A V S A P V L A L H R L S P Y C S E A F P S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V P A D S A L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G P W H P R S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R Q A F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZJD	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-1	-	chim(NtGi1-Gq)/β1/γ1	3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJD (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-1	-		3.06	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ1	3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8ZJE (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3.07	2024-07-03	doi.org/10.1016/j.celrep.2024.114389
	8XGO	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ2	2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-1	-	chim(NtGi1-Gq)/β1/γ2	2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-1	-		2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	Gi1/β1/γ2	3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3	2024-10-30	doi.org/10.1126/sciadv.adn7771

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