psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:?2	19.89	No	Yes	2	0	0
2	L:L:?1	L:L:?3	9.72	No	Yes	2	0	0
3	L:L:?1	L:L:T5	4.41	No	Yes	2	0	0
4	L:L:?2	L:L:?3	20.76	Yes	Yes	2	0	0
5	L:L:?2	L:L:T5	3.54	Yes	Yes	2	0	0
6	L:L:?2	R:R:Y299	7.5	Yes	No	0	0	4
7	L:L:?3	L:L:N4	5.15	Yes	No	2	0	0
8	L:L:?3	R:R:Y190	11	Yes	Yes	2	0	4
9	L:L:N4	R:R:L102	6.87	No	No	0	0	5
10	L:L:N4	R:R:Y190	11.63	No	Yes	2	0	4
11	L:L:F6	L:L:T5	9.08	Yes	Yes	2	0	0
12	L:L:T5	R:R:Y302	7.49	Yes	Yes	2	0	5
13	L:L:F6	R:R:F282	4.29	Yes	No	0	0	5
14	L:L:F6	R:R:P296	2.89	Yes	Yes	2	0	3
15	L:L:F6	R:R:R297	22.45	Yes	No	2	0	2
16	L:L:?7	L:L:L8	8.02	No	Yes	0	0	0
17	L:L:?7	R:R:L102	4.01	No	No	0	0	5
18	L:L:?9	L:L:L8	3.29	Yes	Yes	1	0	0
19	L:L:?11	L:L:L8	10.28	Yes	Yes	1	0	0
20	L:L:L8	R:R:T99	4.42	Yes	No	1	0	6
21	L:L:L8	R:R:V118	2.98	Yes	No	0	0	5
22	L:L:L8	R:R:N119	6.87	Yes	Yes	1	0	5
23	L:L:L8	R:R:Q122	3.99	Yes	Yes	1	0	6
24	L:L:?9	L:L:W10	17.16	Yes	Yes	1	0	0
25	L:L:?11	L:L:?9	8.15	Yes	Yes	1	0	0
26	L:L:?9	R:R:N119	3.27	Yes	Yes	1	0	5
27	L:L:?9	R:R:F195	4.83	Yes	Yes	0	0	6
28	L:L:?9	R:R:F204	11.59	Yes	No	0	0	5
29	L:L:W10	R:R:Q122	3.29	Yes	Yes	1	0	6
30	L:L:W10	R:R:Q123	8.76	Yes	Yes	1	0	4
31	L:L:W10	R:R:V126	12.26	Yes	No	0	0	7
32	L:L:W10	R:R:N208	7.91	Yes	No	1	0	5
33	L:L:W10	R:R:I279	3.52	Yes	Yes	0	0	7
34	L:L:?11	R:R:C95	3.93	Yes	Yes	1	0	7
35	L:L:?11	R:R:T99	10.94	Yes	No	1	0	6
36	L:L:?11	R:R:Q122	6.59	Yes	Yes	1	0	6
37	L:L:?11	R:R:H309	9.55	Yes	No	1	0	6
38	L:L:?11	R:R:Y313	2.9	Yes	Yes	1	0	7
39	R:R:D41	R:R:Y302	8.05	No	Yes	0	2	5
40	R:R:L44	R:R:W43	3.42	No	No	0	5	2
41	R:R:P46	R:R:V45	3.53	No	No	0	6	5
42	R:R:V45	R:R:Y103	17.66	No	Yes	0	5	5
43	R:R:C310	R:R:F49	4.19	No	No	0	5	7
44	R:R:F49	R:R:Y313	4.13	No	Yes	0	7	7
45	R:R:L57	R:R:M53	7.07	No	Yes	0	6	7
46	R:R:L93	R:R:M53	4.24	No	Yes	0	5	7
47	R:R:M53	R:R:V96	12.17	Yes	No	0	7	8
48	R:R:A85	R:R:N60	4.69	No	Yes	0	9	9
49	R:R:D88	R:R:N60	6.73	Yes	Yes	3	9	9
50	R:R:N60	R:R:V89	4.43	Yes	No	0	9	7
51	R:R:N60	R:R:P320	8.15	Yes	No	3	9	9
52	R:R:L62	R:R:V66	2.98	No	No	0	6	7
53	R:R:A85	R:R:V63	3.39	No	No	0	9	9
54	R:R:A85	R:R:I64	3.25	No	No	0	9	7
55	R:R:R69	R:R:Y65	7.2	No	No	0	5	4
56	R:R:R336	R:R:Y65	3.09	No	No	0	5	4
57	R:R:F330	R:R:V66	3.93	Yes	No	0	8	7
58	R:R:I67	R:R:P72	3.39	Yes	Yes	0	7	5
59	R:R:I67	R:R:N78	5.66	Yes	No	0	7	8
60	R:R:I67	R:R:I81	2.94	Yes	No	0	7	8
61	R:R:A333	R:R:H70	2.93	No	No	0	6	5
62	R:R:K71	R:R:R74	4.95	No	No	0	6	7
63	R:R:M73	R:R:P72	3.35	Yes	Yes	0	7	5
64	R:R:F330	R:R:P72	7.22	Yes	Yes	0	8	5
65	R:R:A333	R:R:P72	3.74	No	Yes	0	6	5
66	R:R:M73	R:R:T77	7.53	Yes	No	0	7	8
67	R:R:M73	R:R:N78	5.61	Yes	No	0	7	8
68	R:R:H329	R:R:M73	7.88	No	Yes	0	6	7
69	R:R:R74	R:R:T75	11.64	No	No	0	7	7
70	R:R:N78	R:R:T75	2.92	No	No	0	8	7
71	R:R:V76	R:R:Y80	5.05	No	No	0	6	7
72	R:R:R154	R:R:V76	15.69	Yes	No	0	7	6
73	R:R:R154	R:R:T77	5.17	Yes	No	0	7	8
74	R:R:F79	R:R:L160	3.65	No	No	0	6	3
75	R:R:D139	R:R:Y80	11.49	No	No	0	8	7
76	R:R:A159	R:R:Y80	4	No	No	0	7	7
77	R:R:N83	R:R:T87	2.92	No	Yes	0	9	8
78	R:R:N83	R:R:S163	8.94	No	No	0	9	8
79	R:R:D88	R:R:L84	5.43	Yes	No	0	9	9
80	R:R:L84	R:R:T132	4.42	No	No	0	9	8
81	R:R:L84	R:R:Y323	4.69	No	Yes	0	9	9
82	R:R:T129	R:R:T87	3.14	No	Yes	0	9	8
83	R:R:T132	R:R:T87	6.28	No	Yes	0	8	8
84	R:R:T87	R:R:W167	6.06	Yes	No	0	8	9
85	R:R:D88	R:R:T129	2.89	Yes	No	0	9	9
86	R:R:D88	R:R:S316	5.89	Yes	No	0	9	9
87	R:R:D88	R:R:N319	4.04	Yes	Yes	3	9	9
88	R:R:D88	R:R:P320	3.22	Yes	No	3	9	9
89	R:R:T90	R:R:W167	4.85	No	No	0	6	9
90	R:R:C95	R:R:F91	6.98	Yes	Yes	1	7	7
91	R:R:F91	R:R:S125	6.61	Yes	No	0	7	8
92	R:R:F91	R:R:W276	4.01	Yes	Yes	0	7	8
93	R:R:F91	R:R:Y313	3.09	Yes	Yes	1	7	7
94	R:R:F91	R:R:S316	5.28	Yes	No	0	7	9
95	R:R:C94	R:R:I121	6.55	No	No	0	4	5
96	R:R:C95	R:R:Q122	6.1	Yes	Yes	1	7	6
97	R:R:C95	R:R:Y313	6.72	Yes	Yes	1	7	7
98	R:R:P97	R:R:V96	5.3	No	No	0	9	8
99	R:R:V96	R:R:Y313	6.31	No	Yes	0	8	7
100	R:R:F98	R:R:V118	13.11	No	No	0	6	5
101	R:R:T99	R:R:Y313	4.99	No	Yes	1	6	7
102	R:R:L102	R:R:Y103	4.69	No	Yes	0	5	5
103	R:R:Y103	R:R:Y302	9.93	Yes	Yes	2	5	5
104	R:R:T306	R:R:Y103	3.75	No	Yes	2	4	5
105	R:R:L105	R:R:V109	4.47	No	No	0	4	3
106	R:R:P106	R:R:R188	2.88	No	Yes	0	5	2
107	R:R:G107	R:R:R188	4.5	No	Yes	2	5	2
108	R:R:G107	R:R:Y190	4.35	No	Yes	2	5	4
109	R:R:L110	R:R:W108	11.39	No	No	0	7	8
110	R:R:C115	R:R:W108	7.84	Yes	No	1	9	8
111	R:R:C191	R:R:W108	5.22	No	No	1	9	8
112	R:R:L110	R:R:V109	2.98	No	No	0	7	3
113	R:R:D112	R:R:K116	11.06	No	No	0	3	7
114	R:R:D112	R:R:L183	9.5	No	Yes	0	3	3
115	R:R:F113	R:R:M114	4.98	No	No	0	3	6
116	R:R:C115	R:R:N119	4.72	Yes	Yes	1	9	5
117	R:R:C115	R:R:H181	2.95	Yes	No	1	9	5
118	R:R:C115	R:R:C191	7.28	Yes	No	1	9	9
119	R:R:K116	R:R:R182	3.71	No	No	0	7	5
120	R:R:H181	R:R:N119	15.31	No	Yes	1	5	5
121	R:R:V124	R:R:Y120	8.83	No	Yes	0	5	6
122	R:R:L178	R:R:Y120	8.21	No	Yes	0	5	6
123	R:R:I121	R:R:V124	3.07	No	No	0	5	5
124	R:R:Q123	R:R:S174	2.89	Yes	No	0	4	7
125	R:R:N208	R:R:Q123	3.96	No	Yes	1	5	4
126	R:R:S174	R:R:V124	4.85	No	No	0	7	5
127	R:R:Q127	R:R:S170	2.89	No	No	0	6	7
128	R:R:L212	R:R:Q127	5.32	No	No	0	6	6
129	R:R:A128	R:R:W167	7.78	No	No	0	7	9
130	R:R:F272	R:R:L133	3.65	Yes	No	0	9	8
131	R:R:L133	R:R:N319	4.12	No	Yes	0	8	9
132	R:R:P216	R:R:T134	3.5	Yes	No	0	9	7
133	R:R:M136	R:R:Y323	4.79	No	Yes	0	9	9
134	R:R:S137	R:R:T220	9.59	No	No	6	9	8
135	R:R:S137	R:R:Y224	10.17	No	Yes	6	9	9
136	R:R:C223	R:R:V138	3.42	No	No	0	7	7
137	R:R:D139	R:R:R154	9.53	No	Yes	0	8	7
138	R:R:R140	R:R:Y224	6.17	No	Yes	0	9	9
139	R:R:R140	R:R:Y323	7.2	No	Yes	0	9	9
140	R:R:W141	R:R:Y142	2.89	Yes	No	4	8	4
141	R:R:V145	R:R:W141	7.36	No	Yes	4	7	8
142	R:R:F146	R:R:W141	4.01	Yes	Yes	4	6	8
143	R:R:C223	R:R:W141	5.22	No	Yes	0	7	8
144	R:R:F146	R:R:Y142	3.09	Yes	No	4	6	4
145	R:R:M227	R:R:T144	9.03	No	No	0	9	8
146	R:R:F146	R:R:V145	10.49	Yes	No	4	6	7
147	R:R:H230	R:R:V145	4.15	No	No	0	5	7
148	R:R:R149	R:R:R153	7.46	No	No	0	5	4
149	R:R:H152	R:R:R153	6.77	No	No	0	5	4
150	R:R:P156	R:R:T155	5.25	No	No	0	1	7
151	R:R:R157	R:R:T155	5.17	No	No	0	4	7
152	R:R:F195	R:R:L180	6.09	Yes	No	0	6	4
153	R:R:L180	R:R:P196	3.28	No	No	0	4	4
154	R:R:C191	R:R:H181	2.95	No	No	1	9	5
155	R:R:A194	R:R:R182	4.15	No	No	0	3	5
156	R:R:L183	R:R:P185	8.21	Yes	No	0	3	2
157	R:R:A189	R:R:L183	6.3	No	Yes	0	4	3
158	R:R:G186	R:R:P187	4.06	No	No	0	1	1
159	R:R:P187	R:R:R188	2.88	No	Yes	0	1	2
160	R:R:R188	R:R:Y190	15.43	Yes	Yes	2	2	4
161	R:R:E193	R:R:S192	10.06	No	No	0	4	4
162	R:R:E193	R:R:F195	8.16	No	Yes	0	4	6
163	R:R:E193	R:R:Q286	5.1	No	No	0	4	4
164	R:R:E201	R:R:F195	5.83	Yes	Yes	0	4	6
165	R:R:L200	R:R:P196	4.93	No	No	0	3	4
166	R:R:E201	R:R:R198	11.63	Yes	No	7	4	1
167	R:R:R198	R:R:R202	5.33	No	No	7	1	1
168	R:R:E201	R:R:R202	12.79	Yes	No	7	4	1
169	R:R:L288	R:R:R202	4.86	No	No	0	4	1
170	R:R:L212	R:R:N208	6.87	No	No	0	6	5
171	R:R:L209	R:R:Q280	7.99	No	No	0	5	7
172	R:R:L209	R:R:V284	2.98	No	No	0	5	5
173	R:R:L217	R:R:Y213	9.38	No	No	0	6	8
174	R:R:G277	R:R:Y213	2.9	No	No	0	6	8
175	R:R:Q280	R:R:Y213	5.64	No	No	0	7	8
176	R:R:F272	R:R:P216	5.78	Yes	Yes	0	9	9
177	R:R:F272	R:R:L217	4.87	Yes	No	0	9	6
178	R:R:A273	R:R:L217	3.15	No	No	0	5	6
179	R:R:T220	R:R:Y224	4.99	No	Yes	6	8	9
180	R:R:C221	R:R:V269	3.42	No	No	0	5	8
181	R:R:V265	R:R:Y224	15.14	No	Yes	0	8	9
182	R:R:L228	R:R:V261	4.47	No	No	0	5	8
183	R:R:L228	R:R:S262	6.01	No	No	0	5	7
184	R:R:L231	R:R:V257	4.47	No	No	0	8	6
185	R:R:G232	R:R:R253	4.5	No	Yes	0	5	3
186	R:R:G232	R:R:R258	4.5	No	No	0	5	7
187	R:R:R233	R:R:V234	3.92	No	No	0	5	6
188	R:R:R253	R:R:V234	3.92	Yes	No	0	3	6
189	R:R:L245	R:R:Q248	5.32	No	Yes	0	3	4
190	R:R:Q246	R:R:V249	5.73	No	No	0	4	2
191	R:R:L250	R:R:Q246	3.99	No	No	0	3	4
192	R:R:Q248	R:R:V249	4.3	Yes	No	0	4	2
193	R:R:L250	R:R:R253	3.64	No	Yes	0	3	3
194	R:R:A251	R:R:E252	3.02	No	No	0	1	3
195	R:R:K260	R:R:R263	3.71	No	No	0	8	7
196	R:R:K260	R:R:L264	4.23	No	No	0	8	8
197	R:R:L322	R:R:V268	2.98	Yes	No	0	8	8
198	R:R:V268	R:R:Y323	3.79	No	Yes	0	8	9
199	R:R:C275	R:R:L271	3.17	No	No	0	9	7
200	R:R:L271	R:R:L318	4.15	No	No	0	7	6
201	R:R:L271	R:R:L322	4.15	No	Yes	0	7	8
202	R:R:F272	R:R:W276	6.01	Yes	Yes	0	9	8
203	R:R:C275	R:R:N315	9.45	No	No	0	9	9
204	R:R:S312	R:R:W276	6.18	No	Yes	0	7	8
205	R:R:N315	R:R:W276	11.3	No	Yes	0	9	8
206	R:R:G277	R:R:P278	4.06	No	No	0	6	9
207	R:R:P278	R:R:W307	8.11	No	No	0	9	5
208	R:R:I279	R:R:Q280	4.12	Yes	No	0	7	7
209	R:R:A308	R:R:I279	4.87	No	Yes	0	6	7
210	R:R:I279	R:R:S312	4.64	Yes	No	0	7	7
211	R:R:F282	R:R:L304	6.09	No	No	0	5	6
212	R:R:F282	R:R:K305	8.69	No	No	0	5	4
213	R:R:L285	R:R:P290	6.57	No	Yes	0	6	1
214	R:R:G289	R:R:P290	4.06	No	Yes	0	3	1
215	R:R:P290	R:R:P296	3.9	Yes	Yes	0	1	3
216	R:R:A291	R:R:H295	5.85	No	No	0	1	3
217	R:R:S293	R:R:W294	12.36	No	No	0	3	1
218	R:R:H295	R:R:P296	9.15	No	Yes	0	3	3
219	R:R:P296	R:R:R297	4.32	Yes	No	2	3	2
220	R:R:T306	R:R:Y302	3.75	No	Yes	2	4	5
221	R:R:H309	R:R:K305	13.1	No	No	0	6	4
222	R:R:M311	R:R:W307	10.47	No	No	0	7	5
223	R:R:H309	R:R:Y313	10.89	No	Yes	1	6	7
224	R:R:M311	R:R:S314	4.6	No	No	0	7	5
225	R:R:N315	R:R:S316	2.98	No	No	0	9	9
226	R:R:N319	R:R:P320	3.26	Yes	No	3	9	9
227	R:R:N319	R:R:Y323	8.14	Yes	Yes	0	9	9
228	R:R:A324	R:R:F330	4.16	No	Yes	0	7	8
229	R:R:F325	R:R:F330	3.22	No	Yes	5	6	8
230	R:R:F325	R:R:F334	7.5	No	No	5	6	6
231	R:R:G327	R:R:H329	3.18	No	No	0	8	6
232	R:R:R331	R:R:S328	3.95	No	No	0	8	5
233	R:R:F330	R:R:F334	8.57	Yes	No	5	8	6
234	R:R:F334	R:R:R331	4.28	No	No	0	6	8
235	R:R:Q123	R:R:V177	2.87	Yes	No	0	4	5
236	R:R:I279	R:R:L283	2.85	Yes	No	0	7	5
237	R:R:L92	R:R:M53	2.83	No	Yes	0	7	7
238	R:R:L110	R:R:M114	2.83	No	No	0	7	6
239	L:L:F6	R:R:A301	2.77	Yes	No	0	0	6
240	R:R:L54	R:R:L55	2.77	No	No	0	6	6
241	R:R:A159	R:R:F79	2.77	No	No	0	7	6
242	R:R:L101	R:R:L105	2.77	No	No	0	4	4
243	R:R:L210	R:R:L214	2.77	No	No	0	5	4
244	R:R:A254	R:R:R253	2.77	No	Yes	0	3	3
245	R:R:A259	R:R:R263	2.77	No	No	0	5	7
246	R:R:L264	R:R:L326	2.77	No	No	0	8	7
247	R:R:L281	R:R:L285	2.77	No	No	0	6	6
248	R:R:F79	R:R:S163	2.64	No	No	0	6	8
249	R:R:R154	R:R:V143	2.62	Yes	No	0	7	8
250	R:R:A226	R:R:W141	2.59	No	Yes	0	5	8
251	R:R:V173	R:R:Y207	2.52	No	No	0	5	4
252	R:R:V269	R:R:Y224	2.52	No	Yes	0	8	9
253	R:R:F48	R:R:L47	2.44	No	No	0	4	6
254	R:R:L231	R:R:R258	2.43	No	No	0	8	7
255	R:R:L52	R:R:Y313	2.34	No	Yes	0	7	7
256	R:R:L47	R:R:W43	2.28	No	No	0	6	2
257	R:R:F146	R:R:R149	2.14	Yes	No	0	6	5
258	R:R:G186	R:R:P185	2.03	No	No	0	1	2
259	R:R:A317	R:R:G56	1.95	No	No	0	7	8
260	R:R:A172	R:R:G169	1.95	No	No	0	4	4
261	R:R:A254	R:R:G255	1.95	No	No	0	3	3
262	R:R:C130	R:R:P216	1.88	No	Yes	0	7	9
263	R:R:A175	R:R:P176	1.87	No	No	0	5	6
264	R:R:G59	R:R:V58	1.84	No	No	0	8	4
265	R:R:A205	R:R:A287	1.79	No	No	0	5	5
266	R:R:P185	R:R:S184	1.78	No	No	0	2	3
267	R:R:P156	R:R:V76	1.77	No	No	0	1	6
268	R:R:C223	R:R:S137	1.72	No	No	0	7	9
269	R:R:G56	R:R:L55	1.71	No	No	0	8	6
270	R:R:G56	R:R:L92	1.71	No	No	0	8	7
271	R:R:G111	R:R:L183	1.71	No	Yes	0	8	3
272	R:R:A199	R:R:S197	1.71	No	No	0	1	3
273	R:R:A300	R:R:S298	1.71	No	No	0	3	4
274	R:R:A301	R:R:S298	1.71	No	No	0	6	4
275	R:R:A256	R:R:V257	1.7	No	No	0	5	6
276	R:R:A219	R:R:T134	1.68	No	No	0	6	7
277	R:R:A303	R:R:T306	1.68	No	No	0	2	4
278	R:R:C68	R:R:I64	1.64	No	No	0	4	7
279	R:R:L215	R:R:P216	1.64	No	Yes	0	6	9
280	R:R:G247	R:R:Q248	1.64	No	Yes	0	4	4
281	R:R:A82	R:R:I64	1.62	No	No	0	6	7
282	R:R:A82	R:R:I67	1.62	No	Yes	0	6	7
283	R:R:V261	R:R:V265	1.6	No	No	0	8	8
284	R:R:T144	R:R:V143	1.59	No	No	0	8	8
285	R:R:A179	R:R:L180	1.58	No	No	0	4	4
286	R:R:A211	R:R:L212	1.58	No	No	0	4	6
287	R:R:I166	R:R:V162	1.54	No	No	0	7	5
288	R:R:I166	R:R:T132	1.52	No	No	0	7	8
289	R:R:A333	R:R:Q332	1.52	No	No	0	6	5
290	R:R:A287	R:R:E201	1.51	No	Yes	0	5	4
291	R:R:L200	R:R:S197	1.5	No	No	0	3	3
292	R:R:L158	R:R:T155	1.47	No	No	0	4	7
293	R:R:D41	R:R:V40	1.46	No	No	0	2	4
294	R:R:F146	R:R:P147	1.44	Yes	No	0	6	8
295	R:R:A51	R:R:F48	1.39	No	No	0	5	4
296	R:R:C68	R:R:R69	1.39	No	No	0	4	5
297	R:R:P104	R:R:Y103	1.39	No	Yes	0	5	5
298	R:R:A150	R:R:R154	1.38	No	Yes	0	6	7
299	R:R:L210	R:R:L215	1.38	No	No	0	5	6
300	R:R:L321	R:R:L322	1.38	No	Yes	0	7	8
301	R:R:L322	R:R:L326	1.38	Yes	No	0	8	7
302	R:R:P290	R:R:W294	1.35	Yes	No	0	1	1
303	R:R:A171	R:R:Y120	1.33	No	Yes	0	4	6
304	R:R:A175	R:R:Y120	1.33	No	Yes	0	5	6
305	R:R:R258	R:R:S262	1.32	No	No	0	7	7
306	R:R:E252	R:R:Q248	1.27	No	Yes	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?2	12.9225	4	2	0
2	L:L:?3	11.6575	4	2	0
3	L:L:T5	6.13	4	2	0
4	L:L:F6	8.296	5	2	0
5	L:L:L8	5.69286	7	1	0
6	L:L:?9	8.04833	6	1	0
7	L:L:W10	8.81667	6	1	0
8	L:L:?11	7.47714	7	1	0
9	R:R:M53	6.5775	4	0	7
10	R:R:N60	6	4	3	9
11	R:R:I67	3.4025	4	0	7
12	R:R:P72	4.425	4	0	5
13	R:R:M73	6.0925	4	0	7
14	R:R:T87	4.6	4	0	8
15	R:R:D88	4.7	6	3	9
16	R:R:F91	5.194	5	1	7
17	R:R:C95	5.9325	4	1	7
18	R:R:Y103	7.484	5	2	5
19	R:R:C115	5.6975	4	1	9
20	R:R:N119	7.5425	4	1	5
21	R:R:Y120	4.925	4	0	6
22	R:R:Q122	4.9925	4	1	6
23	R:R:Q123	4.62	4	1	4
24	R:R:W141	4.414	5	4	8
25	R:R:F146	4.234	5	4	6
26	R:R:R154	6.878	5	0	7
27	R:R:L183	6.43	4	0	3
28	R:R:R188	6.4225	4	2	2
29	R:R:Y190	10.6025	4	2	4
30	R:R:F195	6.2275	4	0	6
31	R:R:E201	7.94	4	7	4
32	R:R:P216	3.2	4	0	9
33	R:R:Y224	7.798	5	6	9
34	R:R:Q248	3.1325	4	0	4
35	R:R:R253	3.7075	4	0	3
36	R:R:F272	5.0775	4	0	9
37	R:R:W276	6.875	4	0	8
38	R:R:I279	4	5	0	7
39	R:R:P290	3.97	4	0	1
40	R:R:P296	5.065	4	2	3
41	R:R:Y302	7.305	4	2	5
42	R:R:Y313	5.17125	8	1	7
43	R:R:N319	4.89	4	3	9
44	R:R:L322	2.4725	4	0	8
45	R:R:Y323	5.722	5	0	9
46	R:R:F330	5.42	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N4	R:R:L102	31.5405	6.87	No	No	0	0	5
2	L:L:F6	R:R:F282	12.3019	4.29	Yes	No	0	0	5
3	L:L:?7	R:R:L102	49.1293	4.01	No	No	0	0	5
4	L:L:?7	L:L:L8	50.8497	8.02	No	Yes	0	0	0
5	L:L:?11	L:L:L8	34.6212	10.28	Yes	Yes	1	0	0
6	R:R:F282	R:R:K305	13.3611	8.69	No	No	0	5	4
7	R:R:H309	R:R:K305	13.8298	13.1	No	No	0	6	4
8	L:L:L8	R:R:T99	17.7412	4.42	Yes	No	1	0	6
9	L:L:L8	R:R:N119	20.037	6.87	Yes	Yes	1	0	5
10	L:L:L8	R:R:Q122	18.7891	3.99	Yes	Yes	1	0	6
11	L:L:W10	R:R:Q122	10.5738	3.29	Yes	Yes	1	0	6
12	L:L:?9	R:R:F195	16.4171	4.83	Yes	Yes	0	0	6
13	L:L:?11	R:R:C95	28.2769	3.93	Yes	Yes	1	0	7
14	R:R:C95	R:R:Q122	23.3196	6.1	Yes	Yes	1	7	6
15	R:R:H309	R:R:Y313	10.5681	10.89	No	Yes	1	6	7
16	R:R:F91	R:R:Y313	60.4214	3.09	Yes	Yes	1	7	7
17	R:R:F91	R:R:S316	100	5.28	Yes	No	0	7	9
18	R:R:D88	R:R:S316	95.9057	5.89	Yes	No	0	9	9
19	R:R:D88	R:R:N60	36.7627	6.73	Yes	Yes	3	9	9
20	R:R:A85	R:R:N60	40.3025	4.69	No	Yes	0	9	9
21	R:R:A85	R:R:I64	38.5117	3.25	No	No	0	9	7
22	R:R:A82	R:R:I64	34.1011	1.62	No	No	0	6	7
23	R:R:A82	R:R:I67	33.2076	1.62	No	Yes	0	6	7
24	R:R:I67	R:R:P72	19.8712	3.39	Yes	Yes	0	7	5
25	R:R:I67	R:R:N78	11.7417	5.66	Yes	No	0	7	8
26	R:R:M73	R:R:T77	10.0175	7.53	Yes	No	0	7	8
27	R:R:D88	R:R:T129	17.8384	2.89	Yes	No	0	9	9
28	R:R:T129	R:R:T87	16.9886	3.14	No	Yes	0	9	8
29	R:R:N83	R:R:T87	16.701	2.92	No	Yes	0	9	8
30	R:R:N83	R:R:S163	15.9998	8.94	No	No	0	9	8
31	R:R:F79	R:R:S163	15.3406	2.64	No	No	0	6	8
32	R:R:A159	R:R:F79	14.0337	2.77	No	No	0	7	6
33	R:R:A159	R:R:Y80	13.4145	4	No	No	0	7	7
34	R:R:D88	R:R:L84	30.708	5.43	Yes	No	0	9	9
35	R:R:L84	R:R:Y323	30.988	4.69	No	Yes	0	9	9
36	R:R:D88	R:R:N319	31.5615	4.04	Yes	Yes	3	9	9
37	R:R:N319	R:R:Y323	35.4043	8.14	Yes	Yes	0	9	9
38	R:R:F91	R:R:W276	13.5993	4.01	Yes	Yes	0	7	8
39	R:R:C115	R:R:N119	23.9864	4.72	Yes	Yes	1	9	5
40	R:R:C115	R:R:W108	18.6824	7.84	Yes	No	1	9	8
41	R:R:L110	R:R:W108	16.0475	11.39	No	No	0	7	8
42	R:R:R188	R:R:Y190	24.8647	15.43	Yes	Yes	2	2	4
43	R:R:P187	R:R:R188	21.102	2.88	No	Yes	0	1	2
44	R:R:G186	R:R:P187	19.2025	4.06	No	No	0	1	1
45	R:R:G186	R:R:P185	17.2992	2.03	No	No	0	1	2
46	R:R:L183	R:R:P185	13.4812	8.21	Yes	No	0	3	2
47	R:R:R140	R:R:Y323	60.4824	7.2	No	Yes	0	9	9
48	R:R:R140	R:R:Y224	59.2116	6.17	No	Yes	0	9	9
49	R:R:S137	R:R:Y224	20.357	10.17	No	Yes	6	9	9
50	R:R:C223	R:R:S137	18.8367	1.72	No	No	0	7	9
51	R:R:C223	R:R:W141	15.735	5.22	No	Yes	0	7	8
52	R:R:V265	R:R:Y224	34.1164	15.14	No	Yes	0	8	9
53	R:R:V261	R:R:V265	32.6055	1.6	No	No	0	8	8
54	R:R:L228	R:R:V261	31.0909	4.47	No	No	0	5	8
55	R:R:L228	R:R:S262	29.5725	6.01	No	No	0	5	7
56	R:R:R258	R:R:S262	28.0502	1.32	No	No	0	7	7
57	R:R:G232	R:R:R258	21.9193	4.5	No	No	0	5	7
58	R:R:G232	R:R:R253	20.378	4.5	No	Yes	0	5	3
59	R:R:L250	R:R:R253	12.6181	3.64	No	Yes	0	3	3
60	R:R:L250	R:R:Q246	11.054	3.99	No	No	0	3	4
61	R:R:C275	R:R:N315	12.3304	9.45	No	No	0	9	9
62	R:R:C275	R:R:L271	11.0749	3.17	No	No	0	9	7
63	L:L:?11	R:R:Y313	31.3291	2.9	Yes	Yes	1	0	7
64	R:R:T99	R:R:Y313	17.9508	4.99	No	Yes	1	6	7
65	R:R:L102	R:R:Y103	16.4419	4.69	No	Yes	0	5	5
66	R:R:C95	R:R:F91	50.9945	6.98	Yes	Yes	1	7	7
67	L:L:?11	L:L:?9	26.4803	8.15	Yes	Yes	1	0	0
68	L:L:N4	R:R:Y190	27.3472	11.63	No	Yes	2	0	4
69	L:L:?9	R:R:N119	11.4407	3.27	Yes	Yes	1	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?2	R:R:Y299	7.5	2	Yes	No	0	4	0	1
L:L:?3	R:R:Y190	11	2	Yes	Yes	0	4	0	1
L:L:N4	R:R:L102	6.87	2	No	No	0	5	0	1
L:L:N4	R:R:Y190	11.63	2	No	Yes	0	4	0	1
L:L:T5	R:R:Y302	7.49	2	Yes	Yes	0	5	0	1
L:L:F6	R:R:F282	4.29	2	Yes	No	0	5	0	1
L:L:F6	R:R:P296	2.89	2	Yes	Yes	0	3	0	1
L:L:F6	R:R:R297	22.45	2	Yes	No	0	2	0	1
L:L:?7	R:R:L102	4.01	0	No	No	0	5	0	1
L:L:L8	R:R:T99	4.42	1	Yes	No	0	6	0	1
L:L:L8	R:R:V118	2.98	1	Yes	No	0	5	0	1
L:L:L8	R:R:N119	6.87	1	Yes	Yes	0	5	0	1
L:L:L8	R:R:Q122	3.99	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:N119	3.27	1	Yes	Yes	0	5	0	1
L:L:?9	R:R:F195	4.83	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F204	11.59	1	Yes	No	0	5	0	1
L:L:W10	R:R:Q122	3.29	1	Yes	Yes	0	6	0	1
L:L:W10	R:R:Q123	8.76	1	Yes	Yes	0	4	0	1
L:L:W10	R:R:V126	12.26	1	Yes	No	0	7	0	1
L:L:W10	R:R:N208	7.91	1	Yes	No	0	5	0	1
L:L:W10	R:R:I279	3.52	1	Yes	Yes	0	7	0	1
L:L:?11	R:R:C95	3.93	1	Yes	Yes	0	7	0	1
L:L:?11	R:R:T99	10.94	1	Yes	No	0	6	0	1
L:L:?11	R:R:Q122	6.59	1	Yes	Yes	0	6	0	1
L:L:?11	R:R:H309	9.55	1	Yes	No	0	6	0	1
L:L:?11	R:R:Y313	2.9	1	Yes	Yes	0	7	0	1
R:R:D41	R:R:Y302	8.05	0	No	Yes	2	5	2	1
R:R:F49	R:R:Y313	4.13	0	No	Yes	7	7	2	1
R:R:C95	R:R:F91	6.98	1	Yes	Yes	7	7	1	2
R:R:F91	R:R:Y313	3.09	1	Yes	Yes	7	7	2	1
R:R:C95	R:R:Q122	6.1	1	Yes	Yes	7	6	1	1
R:R:C95	R:R:Y313	6.72	1	Yes	Yes	7	7	1	1
R:R:V96	R:R:Y313	6.31	0	No	Yes	8	7	2	1
R:R:F98	R:R:V118	13.11	0	No	No	6	5	2	1
R:R:T99	R:R:Y313	4.99	1	No	Yes	6	7	1	1
R:R:L102	R:R:Y103	4.69	0	No	Yes	5	5	1	2
R:R:Y103	R:R:Y302	9.93	2	Yes	Yes	5	5	2	1
R:R:T306	R:R:Y103	3.75	2	No	Yes	4	5	2	2
R:R:G107	R:R:R188	4.5	2	No	Yes	5	2	2	2
R:R:G107	R:R:Y190	4.35	2	No	Yes	5	4	2	1
R:R:C115	R:R:N119	4.72	1	Yes	Yes	9	5	2	1
R:R:C115	R:R:H181	2.95	1	Yes	No	9	5	2	2
R:R:H181	R:R:N119	15.31	1	No	Yes	5	5	2	1
R:R:Q123	R:R:S174	2.89	1	Yes	No	4	7	1	2
R:R:N208	R:R:Q123	3.96	1	No	Yes	5	4	1	1
R:R:F195	R:R:L180	6.09	0	Yes	No	6	4	1	2
R:R:R188	R:R:Y190	15.43	2	Yes	Yes	2	4	2	1
R:R:E193	R:R:F195	8.16	0	No	Yes	4	6	2	1
R:R:E201	R:R:F195	5.83	7	Yes	Yes	4	6	2	1
R:R:L212	R:R:N208	6.87	0	No	No	6	5	2	1
R:R:I279	R:R:Q280	4.12	0	Yes	No	7	7	1	2
R:R:A308	R:R:I279	4.87	0	No	Yes	6	7	2	1
R:R:I279	R:R:S312	4.64	0	Yes	No	7	7	1	2
R:R:F282	R:R:L304	6.09	0	No	No	5	6	1	2
R:R:F282	R:R:K305	8.69	0	No	No	5	4	1	2
R:R:P290	R:R:P296	3.9	0	Yes	Yes	1	3	2	1
R:R:H295	R:R:P296	9.15	0	No	Yes	3	3	2	1
R:R:P296	R:R:R297	4.32	2	Yes	No	3	2	1	1
R:R:T306	R:R:Y302	3.75	2	No	Yes	4	5	2	1
R:R:H309	R:R:K305	13.1	1	No	No	6	4	1	2
R:R:H309	R:R:Y313	10.89	1	No	Yes	6	7	1	1
R:R:Q123	R:R:V177	2.87	1	Yes	No	4	5	1	2
R:R:I279	R:R:L283	2.85	0	Yes	No	7	5	1	2
L:L:F6	R:R:A301	2.77	2	Yes	No	0	6	0	1
R:R:L52	R:R:Y313	2.34	0	No	Yes	7	7	2	1
R:R:A301	R:R:S298	1.71	0	No	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8XGU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.88
Number of Linked Nodes	272
Number of Links	306
Number of Hubs	46
Number of Links mediated by Hubs	171
Number of Communities	7
Number of Nodes involved in Communities	48
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	90470
Length Of Smallest Path	3
Average Path Length	15.5528
Length of Longest Path	36
Minimum Path Strength	1.33
Average Path Strength	5.63303
Maximum Path Strength	15.88
Minimum Path Correlation	0.7
Average Path Correlation	0.932195
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	44.4731
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.03
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ACE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ACE
Name	ACETYL GROUP
Synonyms
Identifier
Formula	C2 H4 O
Molecular Weight	44.053
SMILES
PubChem	177
Formal Charge	0
Total Atoms	7
Total Chiral Atoms	0
Total Bonds	6
Total Aromatic Bonds	0


Code	DTY
PDB Residues	L:L:?2
Environment Details	Open EMBL-EBI Page
Code	DTY
Name	D-Tyrosine
Synonyms	D-Tyr (R)-3-(p-Hydroxyphenyl)alanine D-Tyrosin D-Tyrosine (R)-2-Amino-3-(p-hydroxyphenyl)propionic acid
Identifier
Formula	C9 H11 N O3
Molecular Weight	181.189
SMILES
PubChem	71098
Formal Charge	0
Total Atoms	24
Total Chiral Atoms	1
Total Bonds	24
Total Aromatic Bonds	6


Code	HZP
PDB Residues	L:L:?3
Environment Details	Open EMBL-EBI Page
Code	HZP
Name	(4S)-4-hydroxy-L-proline
Synonyms
Identifier
Formula	C5 H9 N O3
Molecular Weight	131.13
SMILES
PubChem	440015
Formal Charge	0
Total Atoms	18
Total Chiral Atoms	2
Total Bonds	18
Total Aromatic Bonds	0


Code	XZA
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	XZA
Name	diazanecarboxylic acid
Synonyms
Identifier
Formula	C H4 N2 O2
Molecular Weight	76.055
SMILES
PubChem	57464706
Formal Charge	0
Total Atoms	9
Total Chiral Atoms	0
Total Bonds	8
Total Aromatic Bonds	0


Code	NMM
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NMM
Name	Tilarginine
Synonyms	L-NMMA
Identifier
Formula	C7 H16 N4 O2
Molecular Weight	188.228
SMILES
PubChem	46906075
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	28
Total Aromatic Bonds	0


Code	NH2
PDB Residues	L:L:?11
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q969F8
Sequence	>8XGU_nogp_Chain_R V D A W L V P L F F A A L M L L G L V G N S L V I Y V I C R H K P M R T V T N F Y I A N L A A T D V T F L L C C V P F T A L L Y P L P G W V L G D F M C K F V N Y I Q Q V S V Q A T C A T L T A M S V D R W Y V T V F P L R A L H R R T P R L A L A V S L S I W V G S A A V S A P V L A L H R L S P G P R A Y C S E A F P S R A L E R A F A L Y N L L A L Y L L P L L A T C A C Y A A M L R H L G R V L Q G Q V L A E R A G A V R A K V S R L V A A V V L L F A A C W G P I Q L F L V L Q A L G P A G S W H P R S Y A A Y A L K T W A H C M S Y S N S A L N P L L Y A F L G S H F R Q A F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8XGS	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-	chim(NtGi1-Gq)/β1/γ2	2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGS (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Metastin	-		2.95	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	chim(NtGi1-Gq)/β1/γ2	2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGO (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		2.68	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-	Gi1/β1/γ2	3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8XGU (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK448	-		3	2024-10-30	doi.org/10.1126/sciadv.adn7771
	8ZJE	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-	chim(NtGi1-Gq)/β1/γ1	3.07	2024-07-03	To be published
	8ZJE (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	TAK-448	-		3.07	2024-07-03	To be published
	8ZJD	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-	chim(NtGi1-Gq)/β1/γ1	3.06	2024-07-03	To be published
	8ZJD (No Gprot)	A	Peptide	Kisspeptin	Kiss1	Homo sapiens	Kisspeptin-10	-		3.06	2024-07-03	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XGU_nogp.zip

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