Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V45 6.115415
2R:R:F49 4.105417
3R:R:N60 7.19409
4R:R:T87 6.45448
5R:R:F91 4.9775407
6R:R:C95 5.98427
7R:R:Y103 7.668515
8R:R:W108 6.21508
9R:R:Y120 5.938556
10R:R:Q122 7.026526
11R:R:F146 5.9175406
12R:R:R154 8.922507
13R:R:Y190 8.0475414
14R:R:F195 8.985636
15R:R:F204 7.02535
16R:R:N208 7.012535
17R:R:L212 5.03506
18R:R:Y224 8.18333669
19R:R:F272 5.4125409
20R:R:W276 7.26508
21R:R:I279 3.8475407
22R:R:W294 5.1125401
23R:R:Y302 6.17167615
24R:R:H309 9.325426
25R:R:Y313 7.148527
26R:R:L322 4.3325408
27R:R:Y323 6.71833609
28R:R:F330 6.85508
29L:L:?3 9.382510
30L:L:N4 6.746510
31L:L:?5 10.475610
32L:L:F6 10.3275410
33L:L:L8 6.7675400
34L:L:?9 8.995630
35L:L:W10 10.5183600
36L:L:?11 8.02520
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:V45 R:R:Y103 10.901212.62YesYes155
2L:L:?5 R:R:Y103 25.82438.66YesYes105
3L:L:?5 R:R:K305 54.01779.11YesNo004
4R:R:H309 R:R:K305 73.589511.79YesNo064
5R:R:H309 R:R:Y313 13.795511.98YesYes267
6R:R:C95 R:R:Y313 18.80655.38YesYes277
7R:R:C95 R:R:F91 63.62866.98YesYes077
8R:R:F91 R:R:S316 55.94323.96YesNo079
9R:R:D88 R:R:S316 51.302610.31NoNo099
10R:R:D88 R:R:N60 63.8248.08NoYes099
11L:L:?11 R:R:H309 13.0759.55YesYes206
12L:L:?11 R:R:C95 13.83623.93YesYes207
13R:R:A85 R:R:N60 52.49124.69NoYes099
14R:R:A85 R:R:V63 44.77333.39NoNo099
15R:R:F330 R:R:V63 40.86546.55YesNo089
16R:R:F330 R:R:I67 26.93153.77YesNo087
17R:R:I67 R:R:N78 22.87715.66NoNo078
18R:R:M73 R:R:N78 18.79029.82NoNo078
19R:R:H70 R:R:M73 14.670710.51NoNo057
20R:R:H309 R:R:I279 49.56443.98YesYes067
21R:R:I279 R:R:S312 46.18584.64YesNo077
22R:R:S312 R:R:W276 46.60914.94NoYes078
23R:R:F272 R:R:W276 78.31969.02YesYes098
24R:R:F272 R:R:L133 70.92734.87YesNo098
25R:R:L133 R:R:Y323 55.1863.52NoYes089
26R:R:L84 R:R:Y323 1007.03NoYes099
27R:R:L84 R:R:T132 98.15195.9NoNo098
28R:R:N83 R:R:T132 86.03765.85NoNo498
29R:R:N83 R:R:S163 84.98745.96NoNo098
30R:R:F79 R:R:S163 83.07423.96NoNo068
31R:R:A159 R:R:F79 77.28574.16NoNo076
32R:R:A159 R:R:Y80 75.33995.34NoNo077
33R:R:D139 R:R:Y80 63.494314.94NoNo087
34R:R:D139 R:R:R154 61.491513.1NoYes087
35R:R:N315 R:R:W276 58.108812.43NoYes098
36R:R:N315 R:R:N319 57.34356.81NoNo099
37R:R:N319 R:R:Y323 70.08874.65NoYes099
38R:R:V162 R:R:Y80 11.10885.05NoNo057
39R:R:T132 R:R:T87 10.2549.42NoYes488
40L:L:?5 R:R:L102 10.02615.11YesNo105
41L:L:?7 R:R:L102 15.94075.35NoNo005
42L:L:?7 L:L:L8 18.44428.02NoYes000
43L:L:L8 R:R:Q122 37.50715.32YesYes006
44L:L:L8 R:R:N119 40.29968.24YesNo005
45R:R:C191 R:R:N119 34.82053.15NoNo095
46R:R:C191 R:R:W108 29.10126.53NoYes098
47R:R:L183 R:R:W108 11.73576.83NoYes038
48R:R:V177 R:R:Y120 31.11213.79NoYes056
49L:L:?9 L:L:L8 24.23275.49YesYes000
50L:L:?9 R:R:F204 15.012610.63YesYes305
51R:R:F204 R:R:V177 31.80413.93YesNo055
52L:L:W10 R:R:Q123 13.144213.14YesNo004
53R:R:L212 R:R:N208 16.42926.87YesYes065
54L:L:W10 R:R:V126 57.14418.39YesNo007
55R:R:L212 R:R:V126 19.96664.47YesNo067
56R:R:L133 R:R:T220 18.64774.42NoNo088
57R:R:F272 R:R:P216 14.21072.89YesNo099
58R:R:T220 R:R:Y224 13.55534.99NoYes689
59R:R:R154 R:R:Y142 45.16814.12YesNo074
60R:R:F146 R:R:Y142 43.09217.22YesNo064
61R:R:F146 R:R:V145 28.331811.8YesNo067
62R:R:M227 R:R:Y224 15.46852.39NoYes099
63R:R:M227 R:R:T144 14.21889.03NoNo098
64R:R:F146 R:R:R149 11.10883.21YesNo065
65L:L:?9 R:R:F195 16.07513.86YesYes306
66R:R:F272 R:R:L217 10.89724.87YesNo096
67R:R:G277 R:R:Y213 10.66925.79NoNo068
68R:R:L231 R:R:T144 12.95692.95NoNo088
69R:R:L231 R:R:V261 10.41284.47NoNo088
70R:R:H230 R:R:V145 21.88392.77NoNo057
71R:R:H230 R:R:R233 19.85265.64NoNo055
72R:R:R233 R:R:R237 17.67897.46NoNo053
73R:R:P238 R:R:R237 13.3071.44NoNo053
74R:R:A241 R:R:P238 11.10881.87NoNo055
75R:R:V268 R:R:Y323 17.67898.83NoYes089
76R:R:L322 R:R:V268 15.4977.45YesNo088
77L:L:?5 L:L:F6 20.996515.74YesYes100
78L:L:F6 R:R:R297 35.040317.1YesNo002
79R:R:H295 R:R:R297 29.78913.39NoNo032
80R:R:H295 R:R:P296 24.43219.15NoNo033
81R:R:P296 R:R:W294 13.61648.11NoYes031
82R:R:F282 R:R:K305 19.148412.41NoNo054
83L:L:F6 R:R:F282 16.60424.29YesNo005
84R:R:F91 R:R:W276 33.03355.01YesYes078
85R:R:D88 R:R:N319 33.97388.08NoNo099
86R:R:C95 R:R:Q122 34.05937.63YesYes276
87L:L:W10 R:R:Q122 21.07796.57YesYes006
88L:L:?9 L:L:W10 36.383618.07YesYes000
89R:R:F204 R:R:Q123 11.24733.51YesNo354
90R:R:V126 R:R:W276 70.52024.9NoYes078
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D41 R:R:V45 4.38 1 No Yes 2 5 2 2
R:R:D41 R:R:Y299 4.6 1 No No 2 4 2 2
R:R:D41 R:R:Y302 6.9 1 No Yes 2 5 2 1
R:R:F49 R:R:V45 3.93 1 Yes Yes 7 5 2 2
R:R:V45 R:R:Y103 12.62 1 Yes Yes 5 5 2 1
R:R:F49 R:R:Y103 4.13 1 Yes Yes 7 5 2 1
R:R:C95 R:R:F91 6.98 2 Yes Yes 7 7 1 2
R:R:F91 R:R:W276 5.01 0 Yes Yes 7 8 2 2
R:R:C95 R:R:Q122 7.63 2 Yes Yes 7 6 1 1
R:R:C95 R:R:Y313 5.38 2 Yes Yes 7 7 1 1
L:L:?11 R:R:C95 3.93 2 Yes Yes 0 7 0 1
R:R:V96 R:R:Y313 8.83 2 No Yes 8 7 2 1
R:R:T99 R:R:Y313 3.75 2 No Yes 6 7 1 1
L:L:?11 R:R:T99 10.94 2 Yes No 0 6 0 1
L:L:N4 R:R:L102 6.87 1 Yes No 0 5 0 1
L:L:?5 R:R:L102 5.11 1 Yes No 0 5 0 1
L:L:?7 R:R:L102 5.35 0 No No 0 5 0 1
R:R:Y103 R:R:Y302 7.94 1 Yes Yes 5 5 1 1
R:R:T306 R:R:Y103 4.99 1 No Yes 4 5 2 1
L:L:?5 R:R:Y103 8.66 1 Yes Yes 0 5 0 1
L:L:N4 R:R:G107 5.09 1 Yes No 0 5 0 1
R:R:Q122 R:R:V118 5.73 2 Yes No 6 5 1 2
R:R:H181 R:R:N119 21.68 0 No No 5 5 2 1
L:L:L8 R:R:N119 8.24 0 Yes No 0 5 0 1
L:L:L8 R:R:Q122 5.32 0 Yes Yes 0 6 0 1
L:L:W10 R:R:Q122 6.57 0 Yes Yes 0 6 0 1
L:L:?11 R:R:Q122 9.88 2 Yes Yes 0 6 0 1
R:R:F204 R:R:Q123 3.51 3 Yes No 5 4 1 1
R:R:N208 R:R:Q123 11.88 3 Yes No 5 4 1 1
L:L:W10 R:R:Q123 13.14 0 Yes No 0 4 0 1
R:R:L212 R:R:V126 4.47 0 Yes No 6 7 2 1
R:R:V126 R:R:W276 4.9 0 No Yes 7 8 1 2
L:L:W10 R:R:V126 18.39 0 Yes No 0 7 0 1
R:R:H181 R:R:V177 4.15 0 No No 5 5 2 2
R:R:F204 R:R:V177 3.93 3 Yes No 5 5 1 2
R:R:F195 R:R:L180 12.18 3 Yes No 6 4 1 2
R:R:E193 R:R:H181 9.85 3 No No 4 5 1 2
R:R:S184 R:R:Y190 5.09 0 No Yes 3 4 2 1
R:R:R188 R:R:Y190 14.4 0 No Yes 2 4 2 1
L:L:?3 R:R:Y190 8.05 1 Yes Yes 0 4 0 1
L:L:N4 R:R:Y190 4.65 1 Yes Yes 0 4 0 1
R:R:E193 R:R:F195 10.49 3 No Yes 4 6 1 1
L:L:?9 R:R:E193 11.56 3 Yes No 0 4 0 1
R:R:F195 R:R:L200 3.65 3 Yes No 6 3 1 2
R:R:E201 R:R:F195 15.16 0 No Yes 4 6 2 1
R:R:F195 R:R:F204 8.57 3 Yes Yes 6 5 1 1
L:L:?9 R:R:F195 3.86 3 Yes Yes 0 6 0 1
R:R:F204 R:R:N208 8.46 3 Yes Yes 5 5 1 1
L:L:?9 R:R:F204 10.63 3 Yes Yes 0 5 0 1
R:R:N208 R:R:Y207 3.49 3 Yes No 5 4 1 2
R:R:L212 R:R:N208 6.87 0 Yes Yes 6 5 2 1
L:L:?9 R:R:N208 4.36 3 Yes Yes 0 5 0 1
R:R:S312 R:R:W276 4.94 0 No Yes 7 8 2 2
R:R:H309 R:R:I279 3.98 2 Yes Yes 6 7 1 1
R:R:I279 R:R:S312 4.64 0 Yes No 7 7 1 2
L:L:W10 R:R:I279 3.52 0 Yes Yes 0 7 0 1
R:R:F282 R:R:L304 7.31 0 No No 5 6 1 2
R:R:F282 R:R:K305 12.41 0 No No 5 4 1 1
L:L:F6 R:R:F282 4.29 1 Yes No 0 5 0 1
R:R:Q286 R:R:R297 5.84 0 No No 4 2 2 1
L:L:F6 R:R:R297 17.1 1 Yes No 0 2 0 1
R:R:Y299 R:R:Y302 4.96 1 No Yes 4 5 2 1
R:R:T306 R:R:Y302 6.24 1 No Yes 4 5 2 1
L:L:?1 R:R:Y302 7.02 1 No Yes 0 5 0 1
L:L:Y2 R:R:Y302 3.97 1 No Yes 0 5 0 1
R:R:H309 R:R:K305 11.79 2 Yes No 6 4 1 1
L:L:?5 R:R:K305 9.11 1 Yes No 0 4 0 1
R:R:H309 R:R:Y313 11.98 2 Yes Yes 6 7 1 1
L:L:?11 R:R:H309 9.55 2 Yes Yes 0 6 0 1
L:L:?11 R:R:Y313 5.8 2 Yes Yes 0 7 0 1
L:L:W10 R:R:L283 3.42 0 Yes No 0 5 0 1
R:R:H295 R:R:R297 3.39 0 No No 3 2 2 1
R:R:A308 R:R:I279 3.25 0 No Yes 6 7 2 1
R:R:C191 R:R:N119 3.15 0 No No 9 5 2 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 8XGO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.44
Number of Linked Nodes 280
Number of Links 308
Number of Hubs 36
Number of Links mediated by Hubs 138
Number of Communities 6
Number of Nodes involved in Communities 39
Number of Links involved in Communities 55
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 67354
Length Of Smallest Path 3
Average Path Length 15.2286
Length of Longest Path 37
Minimum Path Strength 1.335
Average Path Strength 6.92106
Maximum Path Strength 18.23
Minimum Path Correlation 0.7
Average Path Correlation 0.940725
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 57.8994
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 39.0576
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeACE
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeACE
NameACETYL GROUP
Synonyms
Identifier
FormulaC2 H4 O
Molecular Weight44.053
SMILES
PubChem177
Formal Charge0
Total Atoms7
Total Chiral Atoms0
Total Bonds6
Total Aromatic Bonds0

CodeUYA
PDB ResiduesL:L:?3
Environment DetailsOpen EMBL-EBI Page
CodeUYA
Name(4R)-4-hydroxy-D-proline
Synonyms
Identifier
FormulaC5 H9 N O3
Molecular Weight131.13
SMILES
PubChem440014
Formal Charge0
Total Atoms18
Total Chiral Atoms2
Total Bonds18
Total Aromatic Bonds0

CodeDTH
PDB ResiduesL:L:?5
Environment DetailsOpen EMBL-EBI Page
CodeDTH
NameD-THREONINE
Synonyms
Identifier
FormulaC4 H9 N O3
Molecular Weight119.119
SMILES
PubChem6995277
Formal Charge0
Total Atoms17
Total Chiral Atoms2
Total Bonds16
Total Aromatic Bonds0

CodeXZA
PDB ResiduesL:L:?7
Environment DetailsOpen EMBL-EBI Page
CodeXZA
Namediazanecarboxylic acid
Synonyms
Identifier
FormulaC H4 N2 O2
Molecular Weight76.055
SMILES
PubChem129728243
Formal Charge0
Total Atoms9
Total Chiral Atoms0
Total Bonds8
Total Aromatic Bonds0

CodeNMM
PDB ResiduesL:L:?9
Environment DetailsOpen EMBL-EBI Page
CodeNMM
NameTilarginine
SynonymsL-Ng-monomethyl Arginine
Identifier
FormulaC7 H16 N4 O2
Molecular Weight188.228
SMILES
PubChem46906075
Formal Charge0
Total Atoms29
Total Chiral Atoms1
Total Bonds28
Total Aromatic Bonds0

CodeNH2
PDB ResiduesL:L:?11
Environment DetailsOpen EMBL-EBI Page
CodeNH2
NameAMINO GROUP
Synonyms
Identifier
FormulaH2 N
Molecular Weight16.023
SMILES
PubChem123329
Formal Charge0
Total Atoms3
Total Chiral Atoms0
Total Bonds2
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ969F8
Sequence
>8XGO_nogp_Chain_R
AVDAWLVPL FFAALMLLG LVGNSLVIY VICRHKPMR TVTNFYIAN 
LAATDVTFL LCCVPFTAL LYPLPGWVL GDFMCKFVN YIQQVSVQA 
TCATLTAMS VDRWYVTVF PLRALHRRT PRLALAVSL SIWVGSAAV 
SAPVLALHR LSPGPRAYC SEAFPSRAL ERAFALYNL LALYLLPLL 
ATCACYAAM LRHLGRVAV RPAPADSAL QGQVLAERA GAVRAKVSR 
LVAAVVLLF AACWGPIQL FLVLQALGP AGSWHPRSY AAYALKTWA 
HCMSYSNSA LNPLLYAFL GSHFRQAFR RV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZJDAPeptideKisspeptinKiss1Homo sapiensKisspeptin-10-chim(NtGi1-Gq)/β1/γ13.062024-07-03doi.org/10.1016/j.celrep.2024.114389
8ZJD (No Gprot) APeptideKisspeptinKiss1Homo sapiensKisspeptin-10-3.062024-07-03doi.org/10.1016/j.celrep.2024.114389
8ZJEAPeptideKisspeptinKiss1Homo sapiensTAK-448-chim(NtGi1-Gq)/β1/γ13.072024-07-03doi.org/10.1016/j.celrep.2024.114389
8ZJE (No Gprot) APeptideKisspeptinKiss1Homo sapiensTAK-448-3.072024-07-03doi.org/10.1016/j.celrep.2024.114389
8XGOAPeptideKisspeptinKiss1Homo sapiensTAK448-chim(NtGi1-Gq)/β1/γ22.682024-10-30doi.org/10.1126/sciadv.adn7771
8XGO (No Gprot) APeptideKisspeptinKiss1Homo sapiensTAK448-2.682024-10-30doi.org/10.1126/sciadv.adn7771
8XGSAPeptideKisspeptinKiss1Homo sapiensMetastin-chim(NtGi1-Gq)/β1/γ22.952024-10-30doi.org/10.1126/sciadv.adn7771
8XGS (No Gprot) APeptideKisspeptinKiss1Homo sapiensMetastin-2.952024-10-30doi.org/10.1126/sciadv.adn7771
8XGUAPeptideKisspeptinKiss1Homo sapiensTAK448-Gi1/β1/γ232024-10-30doi.org/10.1126/sciadv.adn7771
8XGU (No Gprot) APeptideKisspeptinKiss1Homo sapiensTAK448-32024-10-30doi.org/10.1126/sciadv.adn7771




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8XGO_nogp.zip



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