Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:L48 4.584136
2A:A:S59 3.0125409
3A:A:F211 7.12754148
4A:A:I213 3.95254145
5A:A:P217 5.7025134
6A:A:F218 6.1385147
7A:A:K219 8.97254136
8A:A:M220 5.6675408
9A:A:V223 5.475439
10A:A:R230 8.656539
11A:A:W233 8.3175439
12A:A:F237 5.86639
13A:A:F245 6.27754169
14A:A:D248 9.9625488
15A:A:D251 9.01488
16A:A:R264 12.2489
17A:A:F272 7.8445169
18A:A:F281 6.604539
19A:A:L288 5.68754169
20A:A:F289 5.7425179
21A:A:K292 9.5125489
22A:A:L295 6.7025486
23A:A:I305 5.3885186
24A:A:F309 4.70254189
25A:A:F312 8.6154185
26A:A:F330 7.1865168
27A:A:R331 5.3175403
28A:A:K340 6.3325447
29A:A:Y343 10.3683649
30A:A:F346 10.0467605
31A:A:N354 5.7454179
32A:A:D361 10.3925407
33A:A:D364 9.69448
34A:A:H368 7.286546
35A:A:M375 5.59333616
36A:A:L376 8.5175408
37B:B:L7 3.265408
38B:B:L14 4.445408
39B:B:R22 5.9825406
40B:B:D27 7.5325408
41B:B:I37 4.8925402
42B:B:V40 4.7254103
43B:B:L51 8.74529
44B:B:H54 9.56167629
45B:B:W63 7.684527
46B:B:L70 6.3675425
47B:B:V71 6.6925458
48B:B:D76 8.9575429
49B:B:L79 6.58457
50B:B:I81 4.5025457
51B:B:W82 11.2583629
52B:B:K89 7.72667629
53B:B:I93 7.16457
54B:B:L95 6.574558
55B:B:W99 8.26667639
56B:B:M101 5.6725409
57B:B:Y105 5.28286756
58B:B:N110 7.2754194
59B:B:Y111 4.9445194
60B:B:C114 5.87458
61B:B:I123 5.7425406
62B:B:Y124 6.215656
63B:B:L126 4.93455
64B:B:V133 6.8675454
65B:B:H142 7.64167699
66B:B:F151 4.63167609
67B:B:T159 6.0925499
68B:B:D163 7.76599
69B:B:C166 4.0475468
70B:B:L168 5.67406
71B:B:W169 11.288598
72B:B:F180 10.8175467
73B:B:H183 8.842569
74B:B:L192 4.59465
75B:B:F199 10.2667669
76B:B:V200 6.97476
77B:B:K209 12.315466
78B:B:L210 7.2925405
79B:B:W211 10.8733668
80B:B:H225 9.87679
81B:B:F234 4.6025405
82B:B:F235 7.698336206
83B:B:P236 6.7254207
84B:B:N237 9.3875405
85B:B:F241 8.37676
86B:B:T243 6.114578
87B:B:D247 8.436579
88B:B:R251 12.7325478
89B:B:F253 9.16476
90B:B:R256 8.4825409
91B:B:Y264 6.41605
92B:B:F278 7.6985207
93B:B:R283 6.596676109
94B:B:L285 5.526506
95B:B:Y289 7.668507
96B:B:D291 7.4075408
97B:B:N295 10.1854246
98B:B:D298 9.4654109
99B:B:K301 7.5685105
100B:B:R304 8.574245
101B:B:H311 9.215119
102B:B:L318 4.466506
103B:B:T321 7.845427
104B:B:W332 10.69867159
105B:B:D333 8.13254119
106B:B:K337 9.4554116
107B:B:W339 10.3454119
108G:G:I9 5.5575402
109G:G:R27 7.835408
110G:G:D48 7.89409
111G:G:L51 3.9775406
112G:G:N59 5.546529
113G:G:P60 8.72429
114G:G:F61 5.98857728
115R:R:F12 7.334255
116R:R:M19 9.75405
117R:R:H27 6.6875407
118R:R:L37 7.5385287
119R:R:F45 6.53333617
120R:R:F48 4.42416
121R:R:W53 4.87754295
122R:R:Y62 9.30667618
123R:R:M63 6.5975418
124R:R:F69 9.0175408
125R:R:D70 5.908519
126R:R:L83 4.95754315
127R:R:S88 2.9575408
128R:R:E98 12.35406
129R:R:Y106 5.665408
130R:R:R112 10.37518
131R:R:F120 5.525328
132R:R:R133 5.99833617
133R:R:I138 6.6125418
134R:R:W146 8.7409
135R:R:Y157 9.685404
136R:R:E164 12.3275401
137R:R:F169 5.1725264
138R:R:N171 5.164264
139R:R:F190 5.93509
140R:R:R203 4.6965324
141R:R:I205 3.32754124
142R:R:W218 7.55254124
143R:R:Q221 5.62167646
144R:R:I228 4.8675407
145R:R:F250 10.37754335
146R:R:Q271 6.68754265
147R:R:N280 7.458519
148R:R:D284 9.058519
149R:R:Y288 5.95719
150R:R:Y289 5.38617
151R:R:F295 6.6825418
152R:R:I299 6.312516
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:M61 10.61634.24YesNo256
2B:B:C317 B:B:M61 32.86196.48NoNo076
3B:B:C317 B:B:S316 33.13293.44NoNo079
4B:B:S316 B:B:W332 33.4044.94NoYes099
5A:A:E235 B:B:W332 30.41684.36NoYes1589
6A:A:E235 A:A:K231 98.294813.5NoNo087
7A:A:K231 B:B:D246 98.40528.3NoNo079
8B:B:D246 B:B:N230 98.51516.73NoNo099
9B:B:M188 B:B:N230 98.62455.61NoNo089
10B:B:C204 B:B:M188 98.2734.86NoNo078
11A:A:R230 B:B:C204 98.26439.75YesNo397
12A:A:R230 A:A:S228 99.67773.95YesNo398
13A:A:S228 A:A:W233 1009.88NoYes389
14A:A:F237 A:A:W233 76.43455.01YesYes399
15A:A:F237 B:B:W99 53.255210.02YesYes399
16A:A:E208 B:B:W99 53.448310.9NoYes099
17A:A:E208 A:A:K219 53.408913.5NoYes096
18A:A:K219 A:A:L48 53.07025.64YesYes1366
19A:A:L48 A:A:P217 53.15014.93YesYes1364
20A:A:P217 A:A:R47 43.065211.53YesNo045
21A:A:R47 R:R:H131 42.967615.8NoNo054
22A:A:P217 A:A:V216 20.2683.53YesNo044
23A:A:F218 A:A:V216 18.97025.24YesNo074
24A:A:F211 A:A:F218 17.81178.57YesYes1487
25A:A:F211 A:A:M220 12.39587.46YesYes088
26A:A:V223 A:A:W233 24.36867.36YesYes399
27A:A:L52 A:A:V223 24.23334.47NoYes399
28A:A:F237 A:A:L52 25.25637.31YesNo399
29A:A:L52 A:A:L54 49.20175.54NoNo099
30A:A:I275 A:A:L54 48.44655.71NoNo089
31A:A:F64 A:A:N354 10.70577.25NoYes079
32A:A:F289 A:A:N354 10.11577.25YesYes1799
33A:A:F289 A:A:L246 12.73114.87YesNo097
34A:A:L246 A:A:N291 11.8864.12NoNo079
35A:A:K292 A:A:N291 11.04039.79YesNo099
36A:A:E353 A:A:N351 13.01653.94NoNo059
37A:A:E353 A:A:T352 11.83587.06NoNo059
38A:A:Q67 A:A:T352 10.65454.25NoNo099
39B:B:D290 B:B:R314 73.261623.82NoNo068
40B:B:C271 B:B:D290 72.91376.22NoNo056
41B:B:C271 B:B:D291 72.57146.22NoYes058
42B:B:D291 B:B:Y289 69.96115.75YesYes087
43B:B:I273 B:B:Y289 56.46573.63NoYes067
44B:B:G244 B:B:I273 62.13865.29NoNo056
45B:B:G244 B:B:T243 61.91983.64NoYes058
46B:B:F253 B:B:T243 54.06965.19YesYes768
47B:B:F222 B:B:F253 52.422815NoYes786
48B:B:F222 B:B:Q220 52.33528.2NoNo087
49B:B:D258 B:B:Q220 52.89273.92NoNo077
50B:B:D258 B:B:R22 51.693710.72NoYes076
51B:B:R22 G:G:E22 49.25733.49YesNo069
52B:B:T221 G:G:E22 41.37897.06NoNo079
53B:B:K209 B:B:T221 41.116615.02YesNo067
54B:B:K209 B:B:W211 36.08248.12YesYes668
55B:B:F199 B:B:W211 32.805716.04YesYes698
56B:B:F199 B:B:L192 30.48623.65YesYes695
57B:B:L192 B:B:R150 29.77043.64YesNo056
58B:B:C148 B:B:R150 18.68225.57NoNo066
59B:B:C148 B:B:T102 18.38043.38NoNo068
60B:B:C149 B:B:T102 18.07815.07NoNo088
61B:B:C149 B:B:T159 16.8233.38NoYes989
62A:A:F245 A:A:I275 48.59845.02YesNo098
63A:A:F245 A:A:F272 35.327412.86YesYes1699
64A:A:F245 A:A:L288 14.67363.65YesYes1699
65A:A:F272 A:A:F330 25.36018.57YesYes1698
66A:A:L288 A:A:L290 34.34376.92YesNo1699
67A:A:F346 A:A:L290 54.784417.05YesNo059
68A:A:F346 A:A:L326 44.14733.65YesNo058
69A:A:L265 A:A:L326 43.08082.77NoNo098
70A:A:F309 A:A:L265 42.01383.65YesNo099
71A:A:F309 A:A:I305 23.71693.77YesYes1896
72A:A:F272 A:A:L342 80.35583.65YesNo096
73A:A:L342 A:A:R334 40.528612.15NoNo067
74A:A:L342 A:A:R331 39.97883.64NoYes063
75A:A:R331 R:R:D217 39.70835.96YesNo035
76R:R:D217 R:R:Q220 79.47735.22NoNo055
77A:A:H368 R:R:Q220 12.00154.95YesNo465
78A:A:R334 R:R:D217 40.12289.53NoNo075
79A:A:H368 A:A:P341 17.834512.2YesNo465
80A:A:P341 A:A:Y343 17.252911.13NoYes459
81A:A:D361 A:A:Y343 21.025318.39YesYes079
82A:A:F289 A:A:H345 19.47499.05YesNo099
83A:A:F312 A:A:I305 14.03468.79YesYes1856
84A:A:F312 A:A:P316 19.42957.22YesNo052
85A:A:F309 A:A:F325 15.09257.5YesNo1896
86A:A:F312 A:A:F325 14.01813.93YesNo1856
87R:R:Q220 R:R:Q221 67.13515.12NoYes456
88R:R:Q221 R:R:R211 16.37295.84YesNo065
89A:A:D364 R:R:R211 12.185715.48YesNo085
90R:R:H131 R:R:S130 42.78524.18NoNo044
91A:A:N370 R:R:S130 42.70114.47NoNo084
92A:A:N370 R:R:A122 42.62534.69NoNo088
93A:A:L371 R:R:Q221 80.65816.65NoYes486
94A:A:L371 R:R:L208 80.75986.92NoNo088
95A:A:L374 R:R:A122 42.62554.73NoNo058
96A:A:L374 A:A:L376 34.9386.92NoYes058
97A:A:L374 R:R:R133 13.78083.64NoYes057
98R:R:R133 R:R:T59 11.02085.17YesNo177
99A:A:M375 R:R:T59 10.9457.53YesNo167
100A:A:L376 R:R:R119 57.338117.01YesNo089
101R:R:R119 R:R:Y288 56.46866.17NoYes199
102R:R:M63 R:R:Y288 10.70423.59YesYes189
103A:A:L376 R:R:I228 31.48387.14YesYes087
104B:B:W297 B:B:Y289 12.37798.68NoYes087
105B:B:W297 B:B:Y264 11.135111.58NoYes085
106B:B:G324 B:B:T321 16.21433.64NoYes097
107B:B:G324 B:B:K280 15.92943.49NoNo091
108B:B:K280 G:G:D48 15.76654.15NoYes019
109B:B:T321 B:B:W63 17.300310.92YesYes277
110B:B:S279 G:G:D48 11.279810.31NoYes099
111B:B:S279 G:G:L50 10.95656.01NoNo099
112B:B:M45 G:G:L50 10.63275.65NoNo049
113B:B:L308 B:B:M45 10.30844.24NoNo074
114B:B:H62 B:B:R150 11.924120.31NoNo066
115B:B:H62 B:B:Y105 11.61133.27NoYes066
116B:B:T159 B:B:W169 11.782212.13YesYes998
117B:B:L285 B:B:Y264 10.44417.03YesYes065
118R:R:R112 R:R:Y288 47.15428.23YesYes189
119R:R:F235 R:R:R112 49.62889.62NoYes098
120R:R:F235 R:R:F239 82.868512.86NoNo099
121R:R:F239 R:R:H243 81.973612.44NoNo098
122R:R:F190 R:R:H243 78.82459.05YesNo098
123R:R:E186 R:R:F190 73.82524.66NoYes059
124R:R:E186 R:R:F182 72.45110.49NoNo055
125R:R:F182 R:R:F250 70.998922.51NoYes3355
126R:R:F250 R:R:N254 70.150410.87YesNo053
127R:R:N254 R:R:R253 69.22663.62NoNo034
128R:R:K263 R:R:R253 68.76393.71NoNo034
129R:R:F12 R:R:K263 65.97716.2YesNo053
130R:R:F12 R:R:S267 63.640611.89YesNo054
131R:R:Q271 R:R:S267 62.70254.33YesNo054
132R:R:M19 R:R:Q271 55.600814.95YesYes055
133R:R:M19 R:R:Q23 52.24739.52YesNo055
134R:R:H27 R:R:Q23 18.39814.95YesNo075
135R:R:H170 R:R:Q23 33.62358.65NoNo055
136R:R:H27 R:R:N278 14.8246.38YesNo076
137R:R:N278 R:R:Y101 12.30955.81NoNo065
138R:R:S76 R:R:Y101 23.66955.09NoNo075
139R:R:L100 R:R:S76 22.6463NoNo047
140R:R:L100 R:R:L72 21.6225.54NoNo047
141R:R:L72 R:R:W146 18.54693.42NoYes079
142R:R:H170 R:R:M274 13.00453.94NoNo056
143R:R:M274 R:R:Y101 12.49399.58NoNo065
144R:R:H170 R:R:K80 20.74117.03NoNo057
145R:R:E98 R:R:K80 19.21389.45YesNo067
146R:R:F235 R:R:M197 35.736613.68NoNo097
147R:R:I123 R:R:L208 44.83347.14NoNo088
148R:R:I123 R:R:I207 44.28414.42NoNo086
149R:R:I207 R:R:R124 21.60253.76NoNo066
150R:R:F120 R:R:R124 20.025.34YesNo086
151R:R:C200 R:R:F120 37.85326.98NoYes078
152R:R:C200 R:R:S116 36.73833.44NoNo079
153R:R:I207 R:R:R203 22.21433.76NoYes064
154R:R:F120 R:R:R203 20.01936.41YesYes3284
155R:R:M197 R:R:S116 35.75867.67NoNo079
156R:R:I225 R:R:L208 35.90575.71NoNo058
157R:R:I205 R:R:I225 31.19024.42YesNo1245
158R:R:I205 R:R:I228 31.02784.42YesYes047
159A:A:E235 B:B:R314 67.766810.47NoNo1588
160A:A:H368 R:R:Q221 10.13116.18YesYes466
161B:B:M61 B:B:W63 21.97454.65NoYes267
162A:A:F272 A:A:L288 21.80653.65YesYes1699
163A:A:F330 A:A:L290 21.50133.65YesNo1689
164A:A:D361 A:A:H345 19.145912.61YesNo079
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9IY8
Class A
SubFamily Orphan
Type Orphan
SubType GPR55
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-G13)/Beta1/Gamma2
PDB Resolution 3.01
Date 2025-01-01
D.O.I. doi.org/10.1038/s41422-024-01046-8
Net Summary
Imin 3.44
Number of Linked Nodes 870
Number of Links 1031
Number of Hubs 152
Number of Links mediated by Hubs 576
Number of Communities 33
Number of Nodes involved in Communities 228
Number of Links involved in Communities 310
Path Summary
Number Of Nodes in MetaPath 165
Number Of Links MetaPath 164
Number of Shortest Paths 892202
Length Of Smallest Path 3
Average Path Length 33.805
Length of Longest Path 88
Minimum Path Strength 1.23
Average Path Strength 7.50224
Maximum Path Strength 23.175
Minimum Path Correlation 0.7
Average Path Correlation 0.982149
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.5873
Average % Of Corr. Nodes 45.2237
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 37.6688
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • GTPase regulator activity   • enzyme regulator activity   • guanyl-nucleotide exchange factor activity   • nucleoside-triphosphatase regulator activity   • molecular function regulator activity   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • cation binding   • metal ion binding   • multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • developmental process   • cellular developmental process   • cell differentiation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process
Gene OntologyBiological Process• multicellular organismal process   • system process   • circulatory system process   • regulation of blood pressure   • biological regulation   • regulation of biological quality   • blood circulation   • developmental process   • cellular developmental process   • cell differentiation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • regulation of cell motility   • regulation of fibroblast migration   • fibroblast migration   • regulation of locomotion   • ameboidal-type cell migration   • regulation of cell migration   • cell migration   • cell motility   • locomotion   • multicellular organism development   • embryo development ending in birth or egg hatching   • chordate embryonic development   • anatomical structure development   • embryo development   • in utero embryonic development   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • regulation of developmental process   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • system development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of signaling   • small GTPase-mediated signal transduction   • regulation of small GTPase mediated signal transduction   • regulation of signal transduction   • intracellular signal transduction   • regulation of intracellular signal transduction   • regulation of response to stimulus   • intracellular signaling cassette   • regulation of cell communication   • Rho protein signal transduction   • cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • pigment granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • melanosome   • cytoplasmic vesicle
Gene OntologyCellular Component• cellular anatomical structure   • anchoring junction   • cell junction   • focal adhesion   • cell-substrate junction   • membrane   • membrane-bounded organelle   • intracellular anatomical structure   • pigment granule   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • melanosome   • cytoplasmic vesicle   • organelle   • cytoplasm   • vesicle   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • cytosol   • brush border membrane   • cluster of actin-based cell projections   • plasma membrane bounded cell projection   • brush border   • cell projection   • apical part of cell   • plasma membrane region   • apical plasma membrane   • cell projection membrane   • postsynapse   • synapse   • nucleus   • cannabinoid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • cell communication   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • multicellular organismal process   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • multicellular organism development   • cell differentiation   • osteoclast differentiation   • anatomical structure development   • negative regulation of cellular process   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • developmental process   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • phospholipase C-activating G protein-coupled receptor signaling pathway   • multicellular organismal-level homeostasis   • homeostatic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • system development   • Ras protein signal transduction   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle membrane   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtQ14344
Sequence
>9IY8_Chain_A
LSKEIDKCL SREKTYVKR LVKILLLGA SGKSTFLKQ MRIIGIHEY 
DFEIKNVPF KMVDVGGQR SERKRWFEC FDSVTSILF LVSSFNRLT 
ESLNFETIV NNRVFSNVS IILFLNKTD LLEEKVQIV SIKDYFLEF 
EGDPHCLRD VQKFLVECF RNKRRDQQQ KPLYHHFTT AINTENRLF 
RDVKDTILH DNLKQLMLQ TSAEDKAAA ERDNDDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9IY8_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9IY8_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFRE


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9Y2T6
Sequence
>9IY8_Chain_R
DCLFDGVNE LMKTLQFAV HIPTFVLGL LLNLLAIHG FSTFLKNRW 
PDYAATSIY MINLAVFDL LLVLSLPFK MVLSQVQSP FPSLCTLVE 
CLYFVSMYG SVFTCFISM DRFLAIRYP LLVSHLRSP RKIFGICCT 
IWVLVWTGS IPIYSFHGK VEKYMCFHN MSDDTWSAK VFFPLEVFG 
FLLPMGIMG FCCSRSIHI LLGRRDHTQ DWVQQKACI YSIAASLAV 
FVVSFLPVH LGFFLQFLV RNSFIVECR AKQSISFFL QLSMCFSNV 
NCCLDVFCY YFVIKEFRM NIRAHR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8ZX4ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-chim(NtGi1-G13)/β1/γ23.032024-11-13doi.org/10.1038/s41422-024-01044-w
8ZX4 (No Gprot) ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-3.032024-11-13doi.org/10.1038/s41422-024-01044-w
8ZX5ALipidGPR55GPR55Homo sapiensAM251-chim(NtGi1-G13)/β1/γ22.852024-11-13doi.org/10.1038/s41422-024-01044-w
8ZX5 (No Gprot) ALipidGPR55GPR55Homo sapiensAM251-2.852024-11-13doi.org/10.1038/s41422-024-01044-w
9IYAALipidGPR55GPR55Homo sapiensONO-9710531--3.042025-01-01doi.org/10.1038/s41422-024-01046-8
9IY8AOrphanOrphanGPR55Homo sapiens--chim(NtGi1-G13)/β1/γ23.012025-01-01doi.org/10.1038/s41422-024-01046-8
9IY8 (No Gprot) AOrphanOrphanGPR55Homo sapiens--3.012025-01-01doi.org/10.1038/s41422-024-01046-8
9GE2AOrphanOrphanGPR55Homo sapiensML184-chim(NtGi1-G13)/β1/γ22.512025-03-05doi.org/10.1038/s41467-025-57204-y
9GE2 (No Gprot) AOrphanOrphanGPR55Homo sapiensML184-2.512025-03-05doi.org/10.1038/s41467-025-57204-y
9GE3AOrphanOrphanGPR55Homo sapiensLysophosphatidylinositol-chim(NtGi1-G13)/β1/γ22.872025-03-05doi.org/10.1038/s41467-025-57204-y
9GE3 (No Gprot) AOrphanOrphanGPR55Homo sapiensLysophosphatidylinositol-2.872025-03-05doi.org/10.1038/s41467-025-57204-y




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