Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:F12 7.33435
2R:R:M19 9.75405
3R:R:H27 6.6875407
4R:R:L37 7.538567
5R:R:F45 6.596517
6R:R:F48 4.42416
7R:R:W53 4.8775485
8R:R:Y62 9.30667618
9R:R:F69 9.0175408
10R:R:D70 5.908519
11R:R:L83 4.95754105
12R:R:S88 2.9575408
13R:R:E98 12.35406
14R:R:Y106 5.665408
15R:R:R112 10.37518
16R:R:F120 5.525118
17R:R:R133 6.47517
18R:R:I138 6.6125418
19R:R:W146 8.7409
20R:R:Y157 9.685404
21R:R:E164 12.3275401
22R:R:F169 5.172544
23R:R:N171 5.16444
24R:R:F190 5.93509
25R:R:R203 4.6965114
26R:R:I205 3.3275424
27R:R:W218 7.5525424
28R:R:F250 10.37754125
29R:R:Q271 6.6875445
30R:R:N280 7.458519
31R:R:D284 9.058519
32R:R:Y288 5.95719
33R:R:Y289 5.38617
34R:R:F295 5.848518
35R:R:I299 6.312516
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F12 R:R:K263 91.51396.2YesNo053
2R:R:F12 R:R:S267 89.847111.89YesNo054
3R:R:Q271 R:R:S267 89.09534.33YesNo054
4R:R:F169 R:R:Q271 11.11483.51YesYes445
5R:R:M19 R:R:Q271 83.15514.95YesYes055
6R:R:M19 R:R:Q23 79.82429.52YesNo055
7R:R:H27 R:R:Q23 29.43864.95YesNo075
8R:R:H170 R:R:Q23 52.62748.65NoNo055
9R:R:H27 R:R:N278 23.74996.38YesNo076
10R:R:K263 R:R:R253 93.37153.71NoNo034
11R:R:N254 R:R:R253 93.69493.62NoNo034
12R:R:F250 R:R:N254 94.300210.87YesNo053
13R:R:F182 R:R:F250 94.043222.51NoYes1255
14R:R:E186 R:R:F182 95.649210.49NoNo055
15R:R:E186 R:R:F190 96.38724.66NoYes059
16R:R:F190 R:R:H243 98.66779.05YesNo098
17R:R:F239 R:R:H243 99.734612.44NoNo098
18R:R:F235 R:R:F239 10012.86NoNo099
19R:R:F235 R:R:R112 92.39859.62NoYes098
20R:R:R112 R:R:S108 14.5125.27YesNo189
21R:R:D70 R:R:S108 13.75465.89YesNo199
22R:R:C281 R:R:D70 26.56666.22NoYes089
23R:R:C281 R:R:C282 12.36973.64NoNo087
24R:R:N280 R:R:R112 16.120712.05YesYes198
25R:R:D70 R:R:N280 13.84865.39YesYes199
26R:R:D284 R:R:R112 21.452916.68YesYes198
27R:R:D284 R:R:D70 16.1186.65YesYes199
28R:R:D70 R:R:N38 16.5525.39YesNo099
29R:R:N38 R:R:V285 14.64475.91NoNo099
30R:R:L37 R:R:V285 21.300816.39YesNo079
31R:R:V285 R:R:Y289 12.02157.57NoYes097
32R:R:R112 R:R:Y288 41.34958.23YesYes189
33R:R:M63 R:R:Y288 33.24763.59NoYes189
34R:R:C281 R:R:V74 12.17353.42NoNo085
35R:R:F290 R:R:L37 10.25243.65NoYes687
36R:R:F45 R:R:M63 25.607413.68YesNo178
37R:R:F295 R:R:F45 18.66664.29YesYes187
38R:R:F295 R:R:F48 10.01475.36YesYes186
39R:R:I115 R:R:Y62 10.45429.67NoYes188
40R:R:I115 R:R:Y288 11.23643.63NoYes189
41R:R:N278 R:R:Y101 20.10125.81NoNo065
42R:R:S76 R:R:Y101 39.3515.09NoNo075
43R:R:L100 R:R:S76 37.70073NoNo047
44R:R:L100 R:R:L72 36.0455.54NoNo047
45R:R:L72 R:R:W146 31.04463.42NoYes079
46R:R:H170 R:R:M274 22.79633.94NoNo056
47R:R:M274 R:R:Y101 22.01959.58NoNo065
48R:R:F69 R:R:W146 10.487318.04YesYes089
49R:R:H170 R:R:K80 35.84617.03NoNo057
50R:R:E98 R:R:K80 33.47719.45YesNo067
51R:R:E164 R:R:E98 16.20928.88YesYes016
52R:R:C94 R:R:E164 13.18529.12NoYes091
53R:R:E98 R:R:Y157 16.145622.45YesYes064
54R:R:W146 R:R:W150 15.68686.56YesNo093
55R:R:V103 R:R:W150 13.96474.9NoNo053
56R:R:S153 R:R:V103 10.59516.46NoNo065
57R:R:F235 R:R:M197 55.902913.68NoNo097
58R:R:M197 R:R:S116 54.53197.67NoNo079
59R:R:C200 R:R:S116 53.86573.44NoNo079
60R:R:C200 R:R:F120 53.20236.98NoYes078
61R:R:F120 R:R:R124 27.25495.34YesNo086
62R:R:F120 R:R:R203 24.11486.41YesYes1184
63R:R:I207 R:R:R124 22.74933.76NoNo066
64R:R:I123 R:R:I207 42.60174.42NoNo086
65R:R:I207 R:R:R203 21.80393.76NoYes064
66R:R:I123 R:R:L208 40.8747.14NoNo088
67R:R:I225 R:R:L208 27.01445.71NoNo058
68R:R:I205 R:R:I225 12.6714.42YesNo245
69R:R:L208 R:R:R211 12.70142.43NoNo085
70R:R:Q221 R:R:R211 10.88545.84NoNo065
71R:R:I225 R:R:L209 12.68492.85NoNo253
72R:R:L209 R:R:W218 11.00152.28NoYes234
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9IY8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.44
Number of Linked Nodes 279
Number of Links 312
Number of Hubs 35
Number of Links mediated by Hubs 138
Number of Communities 12
Number of Nodes involved in Communities 60
Number of Links involved in Communities 73
Path Summary
Number Of Nodes in MetaPath 73
Number Of Links MetaPath 72
Number of Shortest Paths 63680
Length Of Smallest Path 3
Average Path Length 19.981
Length of Longest Path 44
Minimum Path Strength 1.23
Average Path Strength 7.702
Maximum Path Strength 18.1
Minimum Path Correlation 0.7
Average Path Correlation 0.934494
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.33333
Average % Of Corr. Nodes 40.3856
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 31.8154
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cannabinoid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • positive regulation of cell communication   • small GTPase-mediated signal transduction   • positive regulation of signal transduction   • regulation of small GTPase mediated signal transduction   • positive regulation of biological process   • regulation of signal transduction   • intracellular signal transduction   • Rho protein signal transduction   • positive regulation of response to stimulus   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of Rho protein signal transduction   • positive regulation of Rho protein signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of small GTPase mediated signal transduction   • positive regulation of signaling   • myeloid leukocyte differentiation   • regulation of leukocyte differentiation   • multicellular organismal process   • cellular developmental process   • regulation of developmental process   • negative regulation of biological process   • cell development   • regulation of cell differentiation   • regulation of cell development   • regulation of osteoclast differentiation   • multicellular organism development   • cell differentiation   • osteoclast differentiation   • anatomical structure development   • negative regulation of cellular process   • regulation of immune system process   • regulation of multicellular organismal process   • negative regulation of cell differentiation   • negative regulation of hemopoiesis   • developmental process   • regulation of multicellular organismal development   • negative regulation of leukocyte differentiation   • hemopoiesis   • regulation of myeloid cell differentiation   • negative regulation of developmental process   • regulation of myeloid leukocyte differentiation   • negative regulation of myeloid cell differentiation   • negative regulation of osteoclast differentiation   • negative regulation of myeloid leukocyte differentiation   • negative regulation of cell development   • myeloid cell differentiation   • negative regulation of immune system process   • immune system process   • regulation of hemopoiesis   • negative regulation of multicellular organismal process   • leukocyte differentiation   • positive regulation of ERK1 and ERK2 cascade   • positive regulation of MAPK cascade   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • phospholipase C-activating G protein-coupled receptor signaling pathway   • multicellular organismal-level homeostasis   • homeostatic process   • tissue remodeling   • bone remodeling   • anatomical structure homeostasis   • tissue homeostasis   • bone resorption   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • signaling receptor binding   • G protein-coupled receptor binding   • D5 dopamine receptor binding   • dopamine receptor binding   • enzyme regulator activity   • hydrolase activity   • GDP binding   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • nucleoside-triphosphatase regulator activity   • GTPase regulator activity   • guanyl-nucleotide exchange factor activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • cation binding   • metal ion binding   • positive regulation of cytosolic calcium ion concentration   • regulation of biological quality   • system process   • circulatory system process   • regulation of blood pressure   • blood circulation   • regulation of vascular associated smooth muscle cell migration   • negative regulation of locomotion   • vascular associated smooth muscle cell migration   • regulation of cell motility   • negative regulation of vascular associated smooth muscle cell migration   • regulation of smooth muscle cell migration   • smooth muscle cell migration   • muscle cell migration   • negative regulation of smooth muscle cell migration   • regulation of locomotion   • regulation of cell migration   • negative regulation of cell motility   • cell migration   • cell motility   • locomotion   • negative regulation of cell migration   • regulation of fibroblast migration   • fibroblast migration   • ameboidal-type cell migration   • embryo development ending in birth or egg hatching   • chordate embryonic development   • embryo development   • in utero embryonic development   • regulation of cell shape   • cell morphogenesis   • regulation of cell morphogenesis   • anatomical structure morphogenesis   • regulation of anatomical structure morphogenesis   • regulation of body fluid levels   • wound healing   • cell activation   • hemostasis   • blood coagulation   • response to stress   • coagulation   • response to wounding   • platelet activation   • branching morphogenesis of an epithelial tube   • angiogenesis   • tube morphogenesis   • epithelial tube morphogenesis   • blood vessel development   • system development   • epithelium development   • blood vessel morphogenesis   • tube development   • morphogenesis of an epithelium   • tissue development   • vasculature development   • circulatory system development   • branching involved in blood vessel morphogenesis   • tissue morphogenesis   • morphogenesis of a branching structure   • anatomical structure formation involved in morphogenesis   • morphogenesis of a branching epithelium   • regulation of cellular component organization   • cellular component organization   • cellular component biogenesis   • cellular component assembly   • regulation of postsynapse assembly   • cell junction assembly   • regulation of synapse structure or activity   • synapse organization   • cellular component organization or biogenesis   • regulation of synapse assembly   • postsynapse organization   • postsynapse assembly   • regulation of postsynapse organization   • nervous system development   • regulation of cellular component biogenesis   • regulation of cell junction assembly   • regulation of synapse organization   • cell junction organization   • synapse assembly   • Rho-activating G protein-coupled receptor signaling pathway   • regulation of vascular associated smooth muscle cell proliferation   • negative regulation of cell population proliferation   • regulation of smooth muscle cell proliferation   • negative regulation of vascular associated smooth muscle cell proliferation   • smooth muscle cell proliferation   • negative regulation of smooth muscle cell proliferation   • regulation of cell population proliferation   • muscle cell proliferation   • vascular associated smooth muscle cell proliferation   • anchoring junction   • focal adhesion   • cell-substrate junction   • pigment granule   • intracellular vesicle   • melanosome   • cytoplasmic vesicle   • brush border membrane   • cluster of actin-based cell projections   • brush border   • plasma membrane region   • cell projection membrane   • postsynapse   • nucleus
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ9Y2T6
Sequence
>9IY8_nogp_Chain_R
DCLFDGVNE LMKTLQFAV HIPTFVLGL LLNLLAIHG FSTFLKNRW 
PDYAATSIY MINLAVFDL LLVLSLPFK MVLSQVQSP FPSLCTLVE 
CLYFVSMYG SVFTCFISM DRFLAIRYP LLVSHLRSP RKIFGICCT 
IWVLVWTGS IPIYSFHGK VEKYMCFHN MSDDTWSAK VFFPLEVFG 
FLLPMGIMG FCCSRSIHI LLGRRDHTQ DWVQQKACI YSIAASLAV 
FVVSFLPVH LGFFLQFLV RNSFIVECR AKQSISFFL QLSMCFSNV 
NCCLDVFCY YFVIKEFRM NIRAHR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9GE3AOrphanOrphanGPR55Homo sapiensLysophosphatidylinositol-chim(CtGi1-G13)/β1/γ22.872025-03-05doi.org/10.1038/s41467-025-57204-y
9GE3 (No Gprot) AOrphanOrphanGPR55Homo sapiensLysophosphatidylinositol-2.872025-03-05doi.org/10.1038/s41467-025-57204-y
9GE2AOrphanOrphanGPR55Homo sapiensML184Cholesterolchim(CtGi1-G13)/β1/γ22.512025-03-05doi.org/10.1038/s41467-025-57204-y
9GE2 (No Gprot) AOrphanOrphanGPR55Homo sapiensML184Cholesterol2.512025-03-05doi.org/10.1038/s41467-025-57204-y
9IY8AOrphanOrphanGPR55Homo sapiens--chim(NtGi1-G13)/β1/γ23.012025-01-01doi.org/10.1038/s41422-024-01046-8
9IY8 (No Gprot) AOrphanOrphanGPR55Homo sapiens--3.012025-01-01doi.org/10.1038/s41422-024-01046-8
9IYAALipidGPR55GPR55Homo sapiensONO-9710531--3.042025-01-0110.1038/s41422-024-01046-8
8ZX5ALipidGPR55GPR55Homo sapiensAM251-chim(NtGi1-G13)/β1/γ22.852024-11-1310.1038/s41422-024-01044-w
8ZX5 (No Gprot) ALipidGPR55GPR55Homo sapiensAM251-2.852024-11-1310.1038/s41422-024-01044-w
8ZX4ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-chim(NtGi1-G13)/β1/γ23.032024-11-1310.1038/s41422-024-01044-w
8ZX4 (No Gprot) ALipidGPR55GPR55Homo sapiensLysophosphatidylinositol-3.032024-11-1310.1038/s41422-024-01044-w




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