psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C10	R:R:C260	7.28	No	No	0	8	7
2	R:R:C10	R:R:Q264	4.58	No	No	0	8	4
3	R:R:F12	R:R:V15	6.55	Yes	No	3	5	5
4	R:R:F12	R:R:K263	6.2	Yes	No	0	5	3
5	R:R:F12	R:R:Q264	4.68	Yes	No	3	5	4
6	R:R:F12	R:R:S267	11.89	Yes	No	0	5	4
7	R:R:D13	R:R:N16	6.73	No	No	0	3	5
8	R:R:E17	R:R:G14	4.91	No	No	0	3	3
9	R:R:Q264	R:R:V15	5.73	No	No	3	4	5
10	R:R:F169	R:R:N16	4.83	Yes	No	0	4	5
11	R:R:L18	R:R:M19	7.07	No	Yes	0	4	5
12	R:R:L18	R:R:L22	5.54	No	No	5	4	5
13	R:R:M19	R:R:Q23	9.52	Yes	No	0	5	5
14	R:R:F268	R:R:M19	7.46	No	Yes	0	2	5
15	R:R:M19	R:R:Q271	14.95	Yes	Yes	0	5	5
16	R:R:K20	R:R:Q85	8.14	No	No	0	5	4
17	R:R:H27	R:R:Q23	4.95	Yes	No	0	7	5
18	R:R:H170	R:R:Q23	8.65	No	No	0	5	5
19	R:R:F24	R:R:I28	7.54	No	No	0	5	4
20	R:R:F24	R:R:M81	12.44	No	No	0	5	7
21	R:R:H27	R:R:M81	6.57	Yes	No	0	7	7
22	R:R:C275	R:R:H27	8.85	No	Yes	0	5	7
23	R:R:H27	R:R:N278	6.38	Yes	No	0	7	6
24	R:R:T30	R:R:V279	4.76	No	No	0	7	4
25	R:R:F31	R:R:V32	3.93	No	No	0	7	5
26	R:R:F31	R:R:P78	10.11	No	No	0	7	9
27	R:R:L33	R:R:L37	6.92	No	Yes	0	5	7
28	R:R:C282	R:R:L33	7.94	No	No	0	7	5
29	R:R:L35	R:R:L39	4.15	No	No	0	5	3
30	R:R:L37	R:R:V285	16.39	Yes	No	0	7	9
31	R:R:F286	R:R:L37	7.31	No	Yes	6	5	7
32	R:R:F290	R:R:L37	3.65	No	Yes	6	8	7
33	R:R:D70	R:R:N38	5.39	Yes	No	0	9	9
34	R:R:N38	R:R:V285	5.91	No	No	0	9	9
35	R:R:I299	R:R:L40	4.28	Yes	No	0	6	5
36	R:R:A41	R:R:Y289	5.34	No	Yes	0	9	7
37	R:R:I42	R:R:I64	4.42	No	No	1	7	5
38	R:R:H43	R:R:S46	4.18	No	No	0	4	3
39	R:R:G44	R:R:T47	3.64	No	No	0	7	3
40	R:R:F295	R:R:G44	4.52	Yes	No	1	8	7
41	R:R:G44	R:R:I299	5.29	No	Yes	1	7	6
42	R:R:F45	R:R:S60	5.28	Yes	No	0	7	7
43	R:R:F45	R:R:M63	13.68	Yes	No	1	7	8
44	R:R:F45	R:R:Y289	7.22	Yes	Yes	1	7	7
45	R:R:F295	R:R:F45	4.29	Yes	Yes	1	8	7
46	R:R:F48	R:R:T47	3.89	Yes	No	0	6	3
47	R:R:E294	R:R:F48	4.66	No	Yes	0	7	6
48	R:R:F295	R:R:F48	5.36	Yes	Yes	1	8	6
49	R:R:F48	R:R:I299	3.77	Yes	Yes	1	6	6
50	R:R:K50	R:R:N51	5.6	No	No	0	5	5
51	R:R:N51	R:R:R52	4.82	No	No	0	5	6
52	R:R:D55	R:R:R52	5.96	No	No	7	6	6
53	R:R:R52	R:R:Y56	11.32	No	No	7	6	4
54	R:R:P54	R:R:W53	5.4	No	Yes	0	6	5
55	R:R:A57	R:R:W53	7.78	No	Yes	8	7	5
56	R:R:P135	R:R:W53	4.05	No	Yes	8	4	5
57	R:R:D55	R:R:Y56	26.44	No	No	7	6	4
58	R:R:A57	R:R:P135	3.74	No	No	8	7	4
59	R:R:A58	R:R:R133	4.15	No	Yes	0	7	7
60	R:R:A58	R:R:I138	4.87	No	Yes	0	7	8
61	R:R:T59	R:R:Y62	13.73	No	Yes	1	7	8
62	R:R:R133	R:R:T59	5.17	Yes	No	1	7	7
63	R:R:I138	R:R:I61	4.42	Yes	No	0	8	6
64	R:R:F114	R:R:Y62	5.16	No	Yes	1	5	8
65	R:R:I115	R:R:Y62	9.67	No	Yes	1	8	8
66	R:R:D118	R:R:Y62	9.2	No	Yes	1	8	8
67	R:R:R133	R:R:Y62	7.2	Yes	Yes	1	7	8
68	R:R:I138	R:R:Y62	10.88	Yes	Yes	1	8	8
69	R:R:M63	R:R:Y288	3.59	No	Yes	1	8	9
70	R:R:M63	R:R:Y289	4.79	No	Yes	1	8	7
71	R:R:C142	R:R:N65	11.02	No	No	0	6	9
72	R:R:N65	R:R:W146	6.78	No	Yes	0	9	9
73	R:R:D284	R:R:L66	6.79	Yes	No	0	9	9
74	R:R:L66	R:R:Y289	4.69	No	Yes	0	9	7
75	R:R:F69	R:R:G107	9.03	Yes	No	0	8	7
76	R:R:F69	R:R:T111	6.49	Yes	No	0	8	8
77	R:R:F69	R:R:W146	18.04	Yes	Yes	0	8	9
78	R:R:D70	R:R:S108	5.89	Yes	No	1	9	9
79	R:R:D70	R:R:N280	5.39	Yes	Yes	1	9	9
80	R:R:C281	R:R:D70	6.22	No	Yes	0	8	9
81	R:R:D284	R:R:D70	6.65	Yes	Yes	1	9	9
82	R:R:L71	R:R:L75	5.54	No	No	9	7	4
83	R:R:L100	R:R:L72	5.54	No	No	0	4	7
84	R:R:L73	R:R:S104	7.51	No	No	0	6	9
85	R:R:S76	R:R:Y101	5.09	No	No	0	7	5
86	R:R:L77	R:R:N278	6.87	No	No	0	8	6
87	R:R:F79	R:R:V97	3.93	No	No	0	6	5
88	R:R:E98	R:R:K80	9.45	Yes	No	0	6	7
89	R:R:H170	R:R:K80	17.03	No	No	0	5	7
90	R:R:L83	R:R:L93	4.15	Yes	No	0	5	5
91	R:R:C94	R:R:L83	7.94	No	Yes	10	9	5
92	R:R:C168	R:R:L83	4.76	No	Yes	10	9	5
93	R:R:F169	R:R:S84	6.61	Yes	No	0	4	6
94	R:R:Q85	R:R:V86	7.16	No	No	0	4	4
95	R:R:P89	R:R:S88	3.56	No	Yes	0	4	8
96	R:R:P91	R:R:S88	3.56	No	Yes	0	6	8
97	R:R:C168	R:R:S88	3.44	No	Yes	0	9	8
98	R:R:F90	R:R:P91	4.33	No	No	0	6	6
99	R:R:F90	R:R:S92	7.93	No	No	0	6	1
100	R:R:C94	R:R:E164	9.12	No	Yes	0	9	1
101	R:R:C168	R:R:C94	5.46	No	No	10	9	9
102	R:R:G161	R:R:T95	5.46	No	No	0	4	7
103	R:R:E164	R:R:T95	4.23	Yes	No	0	1	7
104	R:R:E98	R:R:Y157	22.45	Yes	Yes	0	6	4
105	R:R:E164	R:R:E98	8.88	Yes	Yes	0	1	6
106	R:R:E98	R:R:S173	8.62	Yes	No	0	6	4
107	R:R:C99	R:R:S153	3.44	No	No	0	5	6
108	R:R:M274	R:R:Y101	9.58	No	No	0	6	5
109	R:R:N278	R:R:Y101	5.81	No	No	0	6	5
110	R:R:F102	R:R:Y106	12.38	No	Yes	0	5	8
111	R:R:F102	R:R:Y157	5.16	No	Yes	0	5	4
112	R:R:V103	R:R:V149	4.81	No	No	0	5	7
113	R:R:V103	R:R:W150	4.9	No	No	0	5	3
114	R:R:S153	R:R:V103	6.46	No	No	0	6	5
115	R:R:M105	R:R:Y106	3.59	No	Yes	0	8	8
116	R:R:G189	R:R:Y106	4.35	No	Yes	0	6	8
117	R:R:G107	R:R:V149	5.52	No	No	0	7	7
118	R:R:R112	R:R:S108	5.27	Yes	No	1	8	9
119	R:R:N280	R:R:S108	5.96	Yes	No	1	9	9
120	R:R:F239	R:R:V109	5.24	No	No	0	9	8
121	R:R:F110	R:R:I145	3.77	No	No	0	5	6
122	R:R:F235	R:R:R112	9.62	No	Yes	0	9	8
123	R:R:N280	R:R:R112	12.05	Yes	Yes	1	9	8
124	R:R:D284	R:R:R112	16.68	Yes	Yes	1	9	8
125	R:R:R112	R:R:Y288	8.23	Yes	Yes	1	8	9
126	R:R:F114	R:R:I138	6.28	No	Yes	1	5	8
127	R:R:F114	R:R:I141	10.05	No	No	0	5	5
128	R:R:I115	R:R:R119	7.52	No	No	1	8	9
129	R:R:I115	R:R:Y288	3.63	No	Yes	1	8	9
130	R:R:M197	R:R:S116	7.67	No	No	0	7	9
131	R:R:C200	R:R:S116	3.44	No	No	0	7	9
132	R:R:I196	R:R:M117	4.37	No	No	0	6	5
133	R:R:D118	R:R:R133	11.91	No	Yes	1	8	7
134	R:R:R119	R:R:Y288	6.17	No	Yes	1	9	9
135	R:R:F120	R:R:R124	5.34	Yes	No	0	8	6
136	R:R:F120	R:R:F199	6.43	Yes	No	11	8	4
137	R:R:C200	R:R:F120	6.98	No	Yes	0	7	8
138	R:R:F120	R:R:R203	6.41	Yes	Yes	11	8	4
139	R:R:I123	R:R:I207	4.42	No	No	0	8	6
140	R:R:I123	R:R:L208	7.14	No	No	0	8	8
141	R:R:R124	R:R:Y125	11.32	No	No	0	6	6
142	R:R:I207	R:R:R124	3.76	No	No	0	6	6
143	R:R:R133	R:R:V129	3.92	Yes	No	0	7	6
144	R:R:H131	R:R:S130	4.18	No	No	0	4	4
145	R:R:K137	R:R:S134	4.59	No	No	0	3	6
146	R:R:C143	R:R:F139	4.19	No	No	0	4	4
147	R:R:W146	R:R:W150	6.56	Yes	No	0	9	3
148	R:R:D175	R:R:I156	4.2	No	No	0	2	4
149	R:R:H160	R:R:Y157	6.53	No	Yes	0	5	4
150	R:R:D174	R:R:Y157	4.6	No	Yes	0	2	4
151	R:R:F159	R:R:S158	6.61	No	No	0	4	3
152	R:R:E164	R:R:H160	27.08	Yes	No	0	1	5
153	R:R:H160	R:R:S173	5.58	No	No	0	5	4
154	R:R:M167	R:R:N171	4.21	No	Yes	0	3	4
155	R:R:F169	R:R:N171	9.67	Yes	Yes	4	4	4
156	R:R:F169	R:R:Q271	3.51	Yes	Yes	4	4	5
157	R:R:H170	R:R:M274	3.94	No	No	0	5	6
158	R:R:N171	R:R:Q271	3.96	Yes	Yes	4	4	5
159	R:R:D174	R:R:D175	6.65	No	No	0	2	2
160	R:R:D174	R:R:F246	8.36	No	No	0	2	6
161	R:R:S178	R:R:V181	6.46	No	No	0	4	5
162	R:R:F182	R:R:F183	4.29	No	No	12	5	4
163	R:R:E186	R:R:F182	10.49	No	No	0	5	5
164	R:R:F182	R:R:F250	22.51	No	Yes	12	5	5
165	R:R:F183	R:R:F250	5.36	No	Yes	12	4	5
166	R:R:E186	R:R:V187	4.28	No	No	0	5	4
167	R:R:E186	R:R:F190	4.66	No	Yes	0	5	9
168	R:R:F188	R:R:V187	5.24	No	No	0	4	4
169	R:R:G189	R:R:P193	4.06	No	No	0	6	9
170	R:R:F190	R:R:L191	7.31	Yes	No	0	9	4
171	R:R:F190	R:R:M194	4.98	Yes	No	0	9	5
172	R:R:F190	R:R:L240	3.65	Yes	No	0	9	5
173	R:R:F190	R:R:H243	9.05	Yes	No	0	9	8
174	R:R:I196	R:R:L192	4.28	No	No	0	6	5
175	R:R:F235	R:R:M197	13.68	No	No	0	9	7
176	R:R:F199	R:R:R203	7.48	No	Yes	11	4	4
177	R:R:C201	R:R:L232	12.7	No	No	0	8	8
178	R:R:H206	R:R:R203	4.51	No	Yes	0	4	4
179	R:R:I207	R:R:R203	3.76	No	Yes	0	6	4
180	R:R:I228	R:R:S204	4.64	No	No	0	7	7
181	R:R:I205	R:R:I225	4.42	Yes	No	2	4	5
182	R:R:I205	R:R:I228	4.42	Yes	No	0	4	7
183	R:R:I225	R:R:L208	5.71	No	No	0	5	8
184	R:R:Q221	R:R:R211	5.84	No	No	0	6	5
185	R:R:D213	R:R:R212	3.57	No	No	0	3	3
186	R:R:R212	R:R:W218	10	No	Yes	0	3	4
187	R:R:D217	R:R:Q220	5.22	No	No	0	5	5
188	R:R:V219	R:R:W218	9.81	No	Yes	2	4	4
189	R:R:K222	R:R:W218	8.12	No	Yes	2	5	4
190	R:R:K222	R:R:V219	6.07	No	No	2	5	4
191	R:R:Q220	R:R:Q221	5.12	No	No	0	5	6
192	R:R:C224	R:R:Q221	6.1	No	No	0	7	6
193	R:R:S227	R:R:V291	9.7	No	No	0	7	6
194	R:R:S231	R:R:Y288	8.9	No	Yes	0	7	9
195	R:R:L283	R:R:V234	8.94	No	No	0	7	7
196	R:R:F235	R:R:F239	12.86	No	No	0	9	9
197	R:R:N280	R:R:S238	4.47	Yes	No	0	9	7
198	R:R:F239	R:R:H243	12.44	No	No	0	9	8
199	R:R:P241	R:R:S273	3.56	No	No	0	9	7
200	R:R:H243	R:R:V242	4.15	No	No	0	8	7
201	R:R:S277	R:R:V242	6.46	No	No	0	8	7
202	R:R:F269	R:R:G245	4.52	No	No	0	5	5
203	R:R:F246	R:R:L270	8.53	No	No	0	6	5
204	R:R:F247	R:R:L248	4.87	No	No	0	5	4
205	R:R:F247	R:R:L251	6.09	No	No	0	5	4
206	R:R:L270	R:R:Q249	6.65	No	No	0	5	5
207	R:R:F250	R:R:N254	10.87	Yes	No	0	5	3
208	R:R:K263	R:R:V252	4.55	No	No	0	3	3
209	R:R:N254	R:R:R253	3.62	No	No	0	3	4
210	R:R:K263	R:R:R253	3.71	No	No	0	3	4
211	R:R:A262	R:R:V258	5.09	No	No	0	1	2
212	R:R:E259	R:R:R261	17.45	No	No	0	5	3
213	R:R:A262	R:R:E259	4.53	No	No	0	1	5
214	R:R:Q271	R:R:S267	4.33	Yes	No	0	5	4
215	R:R:F268	R:R:L272	6.09	No	No	0	2	5
216	R:R:F269	R:R:S273	5.28	No	No	0	5	7
217	R:R:L283	R:R:V279	4.47	No	No	0	7	4
218	R:R:D284	R:R:N280	9.42	Yes	Yes	1	9	9
219	R:R:C281	R:R:C282	3.64	No	No	0	8	7
220	R:R:D284	R:R:Y288	5.75	Yes	Yes	1	9	9
221	R:R:V285	R:R:Y289	7.57	No	Yes	0	9	7
222	R:R:F286	R:R:F290	4.29	No	No	6	5	8
223	R:R:C287	R:R:Y288	5.38	No	Yes	0	7	9
224	R:R:F290	R:R:R300	16.03	No	No	0	8	5
225	R:R:E294	R:R:M297	4.06	No	No	0	7	5
226	R:R:F295	R:R:I299	12.56	Yes	Yes	1	8	6
227	R:R:M297	R:R:N298	5.61	No	No	0	5	5
228	R:R:I299	R:R:N298	5.66	Yes	No	0	6	5
229	R:R:C275	R:R:V26	3.42	No	No	0	5	5
230	R:R:G34	R:R:L37	3.42	No	Yes	0	9	7
231	R:R:L72	R:R:W146	3.42	No	Yes	0	7	9
232	R:R:C281	R:R:V74	3.42	No	No	0	8	5
233	R:R:G198	R:R:L232	3.42	No	No	0	4	8
234	R:R:C282	R:R:V279	3.42	No	No	0	7	4
235	R:R:I28	R:R:P29	3.39	No	No	0	4	4
236	R:R:A122	R:R:V129	3.39	No	No	0	8	6
237	R:R:I154	R:R:P155	3.39	No	No	0	4	7
238	R:R:N254	R:R:W177	3.39	No	No	0	3	3
239	R:R:E294	R:R:Y56	3.37	No	No	0	7	4
240	R:R:L192	R:R:P193	3.28	No	No	0	5	9
241	R:R:C99	R:R:I154	3.27	No	No	0	5	4
242	R:R:C201	R:R:I228	3.27	No	No	0	8	7
243	R:R:C113	R:R:M197	3.24	No	No	0	7	7
244	R:R:S273	R:R:V242	3.23	No	No	0	7	7
245	R:R:V252	R:R:V258	3.21	No	No	0	3	2
246	R:R:K50	R:R:S46	3.06	No	No	0	5	3
247	R:R:K80	R:R:V97	3.04	No	No	0	7	5
248	R:R:L49	R:R:S60	3	No	No	0	5	7
249	R:R:L72	R:R:S104	3	No	No	0	7	9
250	R:R:L100	R:R:S76	3	No	No	0	4	7
251	R:R:L83	R:R:V82	2.98	Yes	No	0	5	4
252	R:R:L18	R:R:T21	2.95	No	No	5	4	3
253	R:R:L22	R:R:T21	2.95	No	No	5	5	3
254	R:R:L148	R:R:T144	2.95	No	No	0	4	3
255	R:R:D217	R:R:T215	2.89	No	No	0	5	3
256	R:R:I205	R:R:L209	2.85	Yes	No	2	4	3
257	R:R:I225	R:R:L209	2.85	No	No	2	5	3
258	R:R:K137	R:R:L132	2.82	No	No	0	3	4
259	R:R:M172	R:R:N171	2.8	No	Yes	0	4	4
260	R:R:A179	R:R:F250	2.77	No	Yes	0	3	5
261	R:R:L240	R:R:L244	2.77	No	No	0	5	5
262	R:R:L244	R:R:L248	2.77	No	No	0	5	4
263	R:R:A67	R:R:Y289	2.67	No	Yes	0	8	7
264	R:R:E17	R:R:N16	2.63	No	No	0	3	5
265	R:R:F45	R:R:I64	2.51	Yes	No	1	7	5
266	R:R:F69	R:R:I145	2.51	Yes	No	0	8	6
267	R:R:F295	R:R:I292	2.51	Yes	No	0	8	7
268	R:R:F120	R:R:L121	2.44	Yes	No	0	8	5
269	R:R:F276	R:R:L272	2.44	No	No	0	6	5
270	R:R:L208	R:R:R211	2.43	No	No	0	8	5
271	R:R:K222	R:R:Y226	2.39	No	No	0	5	5
272	R:R:L185	R:R:Y106	2.34	No	Yes	0	5	8
273	R:R:L128	R:R:Y125	2.34	No	No	0	5	6
274	R:R:L49	R:R:W53	2.28	No	Yes	0	5	5
275	R:R:L209	R:R:W218	2.28	No	Yes	2	3	4
276	R:R:R296	R:R:R300	2.13	No	No	0	8	5
277	R:R:G152	R:R:P155	2.03	No	No	0	4	7
278	R:R:G152	R:R:T151	1.82	No	No	0	4	3
279	R:R:A230	R:R:C287	1.81	No	No	0	5	7
280	R:R:P135	R:R:S134	1.78	No	No	0	4	6
281	R:R:L77	R:R:P78	1.64	No	No	0	8	9
282	R:R:L127	R:R:P126	1.64	No	No	0	5	8
283	R:R:A229	R:R:I205	1.62	No	Yes	0	3	4
284	R:R:S238	R:R:V237	1.62	No	No	0	7	5
285	R:R:S178	R:R:T176	1.6	No	No	0	4	2
286	R:R:I266	R:R:S267	1.55	No	No	0	5	4
287	R:R:I42	R:R:V68	1.54	No	No	1	7	5
288	R:R:I64	R:R:V68	1.54	No	No	1	5	5
289	R:R:I292	R:R:V291	1.54	No	No	0	7	6
290	R:R:K162	R:R:S158	1.53	No	No	0	4	3
291	R:R:K180	R:R:S178	1.53	No	No	0	3	4
292	R:R:M194	R:R:V236	1.52	No	No	0	5	5
293	R:R:F139	R:R:G140	1.51	No	No	0	4	1
294	R:R:G140	R:R:R136	1.5	No	No	0	1	4
295	R:R:L251	R:R:S255	1.5	No	No	0	4	1
296	R:R:L71	R:R:V74	1.49	No	No	9	7	5
297	R:R:L75	R:R:V74	1.49	No	No	9	4	5
298	R:R:F183	R:R:P184	1.44	No	No	0	4	4
299	R:R:Q87	R:R:V86	1.43	No	No	0	3	4
300	R:R:P126	R:R:Y125	1.39	No	No	0	8	6
301	R:R:L35	R:R:L71	1.38	No	No	0	5	7
302	R:R:L93	R:R:L96	1.38	No	No	0	5	4
303	R:R:H214	R:R:T215	1.37	No	No	0	4	3
304	R:R:D13	R:R:L11	1.36	No	No	0	3	4
305	R:R:R136	R:R:S134	1.32	No	No	0	4	6
306	R:R:R203	R:R:S202	1.32	Yes	No	0	4	3
307	R:R:F256	R:R:S255	1.32	No	No	0	2	1
308	R:R:H131	R:R:L127	1.29	No	No	0	4	5
309	R:R:H131	R:R:L132	1.29	No	No	0	4	4
310	R:R:S88	R:R:Y166	1.27	Yes	No	0	8	5
311	R:R:F169	R:R:K20	1.24	Yes	No	0	4	5
312	R:R:K165	R:R:Y166	1.19	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F12	7.33	4	3	5
2	R:R:M19	9.75	4	0	5
3	R:R:H27	6.6875	4	0	7
4	R:R:L37	7.538	5	6	7
5	R:R:F45	6.596	5	1	7
6	R:R:F48	4.42	4	1	6
7	R:R:W53	4.8775	4	8	5
8	R:R:Y62	9.30667	6	1	8
9	R:R:F69	9.0175	4	0	8
10	R:R:D70	5.908	5	1	9
11	R:R:L83	4.9575	4	10	5
12	R:R:S88	2.9575	4	0	8
13	R:R:E98	12.35	4	0	6
14	R:R:Y106	5.665	4	0	8
15	R:R:R112	10.37	5	1	8
16	R:R:F120	5.52	5	11	8
17	R:R:R133	6.47	5	1	7
18	R:R:I138	6.6125	4	1	8
19	R:R:W146	8.7	4	0	9
20	R:R:Y157	9.685	4	0	4
21	R:R:E164	12.3275	4	0	1
22	R:R:F169	5.172	5	4	4
23	R:R:N171	5.16	4	4	4
24	R:R:F190	5.93	5	0	9
25	R:R:R203	4.696	5	11	4
26	R:R:I205	3.3275	4	2	4
27	R:R:W218	7.5525	4	2	4
28	R:R:F250	10.3775	4	12	5
29	R:R:Q271	6.6875	4	4	5
30	R:R:N280	7.458	5	1	9
31	R:R:D284	9.058	5	1	9
32	R:R:Y288	5.95	7	1	9
33	R:R:Y289	5.38	6	1	7
34	R:R:F295	5.848	5	1	8
35	R:R:I299	6.312	5	1	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F12	R:R:K263	91.5139	6.2	Yes	No	0	5	3
2	R:R:F12	R:R:S267	89.8471	11.89	Yes	No	0	5	4
3	R:R:Q271	R:R:S267	89.0953	4.33	Yes	No	0	5	4
4	R:R:F169	R:R:Q271	11.1148	3.51	Yes	Yes	4	4	5
5	R:R:M19	R:R:Q271	83.155	14.95	Yes	Yes	0	5	5
6	R:R:M19	R:R:Q23	79.8242	9.52	Yes	No	0	5	5
7	R:R:H27	R:R:Q23	29.4386	4.95	Yes	No	0	7	5
8	R:R:H170	R:R:Q23	52.6274	8.65	No	No	0	5	5
9	R:R:H27	R:R:N278	23.7499	6.38	Yes	No	0	7	6
10	R:R:K263	R:R:R253	93.3715	3.71	No	No	0	3	4
11	R:R:N254	R:R:R253	93.6949	3.62	No	No	0	3	4
12	R:R:F250	R:R:N254	94.3002	10.87	Yes	No	0	5	3
13	R:R:F182	R:R:F250	94.0432	22.51	No	Yes	12	5	5
14	R:R:E186	R:R:F182	95.6492	10.49	No	No	0	5	5
15	R:R:E186	R:R:F190	96.3872	4.66	No	Yes	0	5	9
16	R:R:F190	R:R:H243	98.6677	9.05	Yes	No	0	9	8
17	R:R:F239	R:R:H243	99.7346	12.44	No	No	0	9	8
18	R:R:F235	R:R:F239	100	12.86	No	No	0	9	9
19	R:R:F235	R:R:R112	92.3985	9.62	No	Yes	0	9	8
20	R:R:R112	R:R:S108	14.512	5.27	Yes	No	1	8	9
21	R:R:D70	R:R:S108	13.7546	5.89	Yes	No	1	9	9
22	R:R:C281	R:R:D70	26.5666	6.22	No	Yes	0	8	9
23	R:R:C281	R:R:C282	12.3697	3.64	No	No	0	8	7
24	R:R:N280	R:R:R112	16.1207	12.05	Yes	Yes	1	9	8
25	R:R:D70	R:R:N280	13.8486	5.39	Yes	Yes	1	9	9
26	R:R:D284	R:R:R112	21.4529	16.68	Yes	Yes	1	9	8
27	R:R:D284	R:R:D70	16.118	6.65	Yes	Yes	1	9	9
28	R:R:D70	R:R:N38	16.552	5.39	Yes	No	0	9	9
29	R:R:N38	R:R:V285	14.6447	5.91	No	No	0	9	9
30	R:R:L37	R:R:V285	21.3008	16.39	Yes	No	0	7	9
31	R:R:V285	R:R:Y289	12.0215	7.57	No	Yes	0	9	7
32	R:R:R112	R:R:Y288	41.3495	8.23	Yes	Yes	1	8	9
33	R:R:M63	R:R:Y288	33.2476	3.59	No	Yes	1	8	9
34	R:R:C281	R:R:V74	12.1735	3.42	No	No	0	8	5
35	R:R:F290	R:R:L37	10.2524	3.65	No	Yes	6	8	7
36	R:R:F45	R:R:M63	25.6074	13.68	Yes	No	1	7	8
37	R:R:F295	R:R:F45	18.6666	4.29	Yes	Yes	1	8	7
38	R:R:F295	R:R:F48	10.0147	5.36	Yes	Yes	1	8	6
39	R:R:I115	R:R:Y62	10.4542	9.67	No	Yes	1	8	8
40	R:R:I115	R:R:Y288	11.2364	3.63	No	Yes	1	8	9
41	R:R:N278	R:R:Y101	20.1012	5.81	No	No	0	6	5
42	R:R:S76	R:R:Y101	39.351	5.09	No	No	0	7	5
43	R:R:L100	R:R:S76	37.7007	3	No	No	0	4	7
44	R:R:L100	R:R:L72	36.045	5.54	No	No	0	4	7
45	R:R:L72	R:R:W146	31.0446	3.42	No	Yes	0	7	9
46	R:R:H170	R:R:M274	22.7963	3.94	No	No	0	5	6
47	R:R:M274	R:R:Y101	22.0195	9.58	No	No	0	6	5
48	R:R:F69	R:R:W146	10.4873	18.04	Yes	Yes	0	8	9
49	R:R:H170	R:R:K80	35.846	17.03	No	No	0	5	7
50	R:R:E98	R:R:K80	33.4771	9.45	Yes	No	0	6	7
51	R:R:E164	R:R:E98	16.2092	8.88	Yes	Yes	0	1	6
52	R:R:C94	R:R:E164	13.1852	9.12	No	Yes	0	9	1
53	R:R:E98	R:R:Y157	16.1456	22.45	Yes	Yes	0	6	4
54	R:R:W146	R:R:W150	15.6868	6.56	Yes	No	0	9	3
55	R:R:V103	R:R:W150	13.9647	4.9	No	No	0	5	3
56	R:R:S153	R:R:V103	10.5951	6.46	No	No	0	6	5
57	R:R:F235	R:R:M197	55.9029	13.68	No	No	0	9	7
58	R:R:M197	R:R:S116	54.5319	7.67	No	No	0	7	9
59	R:R:C200	R:R:S116	53.8657	3.44	No	No	0	7	9
60	R:R:C200	R:R:F120	53.2023	6.98	No	Yes	0	7	8
61	R:R:F120	R:R:R124	27.2549	5.34	Yes	No	0	8	6
62	R:R:F120	R:R:R203	24.1148	6.41	Yes	Yes	11	8	4
63	R:R:I207	R:R:R124	22.7493	3.76	No	No	0	6	6
64	R:R:I123	R:R:I207	42.6017	4.42	No	No	0	8	6
65	R:R:I207	R:R:R203	21.8039	3.76	No	Yes	0	6	4
66	R:R:I123	R:R:L208	40.874	7.14	No	No	0	8	8
67	R:R:I225	R:R:L208	27.0144	5.71	No	No	0	5	8
68	R:R:I205	R:R:I225	12.671	4.42	Yes	No	2	4	5
69	R:R:L208	R:R:R211	12.7014	2.43	No	No	0	8	5
70	R:R:Q221	R:R:R211	10.8854	5.84	No	No	0	6	5
71	R:R:I225	R:R:L209	12.6849	2.85	No	No	2	5	3
72	R:R:L209	R:R:W218	11.0015	2.28	No	Yes	2	3	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9IY8_nogp

PDB Summary
PDB	9IY8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.44
Number of Linked Nodes	279
Number of Links	312
Number of Hubs	35
Number of Links mediated by Hubs	138
Number of Communities	12
Number of Nodes involved in Communities	60
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	63680
Length Of Smallest Path	3
Average Path Length	19.981
Length of Longest Path	44
Minimum Path Strength	1.23
Average Path Strength	7.702
Maximum Path Strength	18.1
Minimum Path Correlation	0.7
Average Path Correlation	0.934532
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	40.3881
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	31.8154
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cation binding • metal ion binding • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process
Gene Ontology	Biological Process	• multicellular organismal process • system process • circulatory system process • regulation of blood pressure • biological regulation • regulation of biological quality • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • plasma membrane bounded cell projection • brush border • cell projection • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • synapse • nucleus • cannabinoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • myeloid leukocyte differentiation • regulation of leukocyte differentiation • multicellular organismal process • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal-level homeostasis • homeostatic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T6
Sequence	>9IY8_nogp_Chain_R D C L F D G V N E L M K T L Q F A V H I P T F V L G L L L N L L A I H G F S T F L K N R W P D Y A A T S I Y M I N L A V F D L L L V L S L P F K M V L S Q V Q S P F P S L C T L V E C L Y F V S M Y G S V F T C F I S M D R F L A I R Y P L L V S H L R S P R K I F G I C C T I W V L V W T G S I P I Y S F H G K V E K Y M C F H N M S D D T W S A K V F F P L E V F G F L L P M G I M G F C C S R S I H I L L G R R D H T Q D W V Q Q K A C I Y S I A A S L A V F V V S F L P V H L G F F L Q F L V R N S F I V E C R A K Q S I S F F L Q L S M C F S N V N C C L D V F C Y Y F V I K E F R M N I R A H R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZX4	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(NtGi1-G13)/β1/γ2	3.03	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX4 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-		3.03	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	9IYA	A	Lipid	GPR55	GPR55	Homo sapiens	ONO-9710531	-	-	3.04	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IY8	A	Orphan	Orphan	GPR55	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IY8 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	-	-		3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9GE2	A	Orphan	Orphan	GPR55	Homo sapiens	ML184	-	chim(NtGi1-G13)/β1/γ2	2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE2 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	ML184	-		2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE3	A	Orphan	Orphan	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(NtGi1-G13)/β1/γ2	2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE3 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	Lysophosphatidylinositol	-		2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y

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