psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D9	R:R:K263	6.91	No	No	0	6	3
2	R:R:C10	R:R:F12	4.19	No	No	0	8	5
3	R:R:D13	R:R:L11	6.79	No	No	0	3	4
4	R:R:F12	R:R:S267	6.61	No	No	0	5	4
5	R:R:D13	R:R:G14	5.03	No	No	0	3	3
6	R:R:E17	R:R:G14	4.91	No	No	0	3	3
7	R:R:H170	R:R:N16	5.1	No	No	0	5	5
8	R:R:L18	R:R:L22	4.15	No	No	0	4	5
9	R:R:F268	R:R:L18	6.09	No	No	0	2	4
10	R:R:L22	R:R:M19	4.24	No	Yes	3	5	5
11	R:R:F268	R:R:M19	6.22	No	Yes	0	2	5
12	R:R:M19	R:R:Q271	13.59	Yes	No	0	5	5
13	R:R:L272	R:R:M19	4.24	No	Yes	3	5	5
14	R:R:K20	R:R:Q85	14.92	No	No	0	5	4
15	R:R:L22	R:R:L272	4.15	No	No	3	5	5
16	R:R:F24	R:R:Q23	5.86	No	Yes	1	5	5
17	R:R:H27	R:R:Q23	4.95	Yes	Yes	1	7	5
18	R:R:M81	R:R:Q23	4.08	Yes	Yes	1	7	5
19	R:R:Q23	R:R:S84	4.33	Yes	No	0	5	6
20	R:R:F24	R:R:M81	6.22	No	Yes	1	5	7
21	R:R:F24	R:R:Q85	4.68	No	No	0	5	4
22	R:R:F276	R:R:V26	5.24	No	No	0	6	5
23	R:R:H27	R:R:L77	10.29	Yes	No	0	7	8
24	R:R:H27	R:R:K80	11.79	Yes	No	1	7	7
25	R:R:H27	R:R:M81	6.57	Yes	Yes	1	7	7
26	R:R:C275	R:R:H27	7.37	No	Yes	0	5	7
27	R:R:H27	R:R:N278	6.38	Yes	No	1	7	6
28	R:R:I28	R:R:M81	5.83	No	Yes	0	4	7
29	R:R:F31	R:R:P78	11.56	No	No	0	7	9
30	R:R:L37	R:R:V285	7.45	Yes	No	0	7	9
31	R:R:F286	R:R:L37	4.87	No	Yes	0	5	7
32	R:R:D70	R:R:N38	8.08	Yes	No	0	9	9
33	R:R:N38	R:R:V285	4.43	No	No	0	9	9
34	R:R:L39	R:R:L71	4.15	No	No	0	3	7
35	R:R:I299	R:R:L40	9.99	No	No	0	6	5
36	R:R:A41	R:R:Y289	4	No	Yes	0	9	7
37	R:R:H43	R:R:T47	4.11	No	No	0	4	3
38	R:R:F45	R:R:S60	3.96	Yes	No	0	7	7
39	R:R:F45	R:R:M63	13.68	Yes	Yes	2	7	8
40	R:R:F45	R:R:Y289	9.28	Yes	Yes	2	7	7
41	R:R:F295	R:R:F45	5.36	Yes	Yes	2	8	7
42	R:R:F48	R:R:R52	8.55	No	No	0	6	6
43	R:R:F48	R:R:S60	3.96	No	No	0	6	7
44	R:R:F48	R:R:N298	7.25	No	No	0	6	5
45	R:R:D55	R:R:R52	10.72	No	No	4	6	6
46	R:R:R52	R:R:Y56	6.17	No	No	4	6	4
47	R:R:P54	R:R:W53	4.05	No	No	0	6	5
48	R:R:A57	R:R:W53	12.96	No	No	0	7	5
49	R:R:P135	R:R:W53	9.46	No	No	0	4	5
50	R:R:D55	R:R:P54	4.83	No	No	0	6	6
51	R:R:D55	R:R:Y56	11.49	No	No	4	6	4
52	R:R:E294	R:R:Y56	11.22	No	No	0	7	4
53	R:R:A58	R:R:R133	5.53	No	Yes	0	7	7
54	R:R:A58	R:R:I138	4.87	No	No	0	7	8
55	R:R:T59	R:R:Y62	11.24	No	Yes	0	7	8
56	R:R:R133	R:R:T59	5.17	Yes	No	0	7	7
57	R:R:M63	R:R:Y62	8.38	Yes	Yes	2	8	8
58	R:R:F114	R:R:Y62	9.28	Yes	Yes	0	5	8
59	R:R:I115	R:R:Y62	15.71	No	Yes	2	8	8
60	R:R:D118	R:R:Y62	6.9	No	Yes	0	8	8
61	R:R:I115	R:R:M63	4.37	No	Yes	2	8	8
62	R:R:M63	R:R:Y289	4.79	Yes	Yes	2	8	7
63	R:R:F69	R:R:N65	6.04	No	Yes	5	8	9
64	R:R:N65	R:R:T111	7.31	Yes	No	0	9	8
65	R:R:C142	R:R:N65	12.6	No	Yes	0	6	9
66	R:R:N65	R:R:W146	11.3	Yes	Yes	5	9	9
67	R:R:L66	R:R:T111	7.37	Yes	No	0	9	8
68	R:R:I112	R:R:L66	4.28	No	Yes	2	8	9
69	R:R:D284	R:R:L66	9.5	Yes	Yes	2	9	9
70	R:R:L66	R:R:Y289	7.03	Yes	Yes	2	9	7
71	R:R:A67	R:R:Y289	4	No	Yes	0	8	7
72	R:R:F69	R:R:G107	9.03	No	No	0	8	7
73	R:R:F69	R:R:W146	27.06	No	Yes	5	8	9
74	R:R:C281	R:R:D70	4.67	No	Yes	0	8	9
75	R:R:D284	R:R:D70	9.31	Yes	Yes	0	9	9
76	R:R:L100	R:R:L72	4.15	No	No	0	4	7
77	R:R:L72	R:R:S104	6.01	No	No	0	7	9
78	R:R:L73	R:R:Y101	4.69	No	Yes	1	6	5
79	R:R:L73	R:R:S104	4.5	No	No	0	6	9
80	R:R:L73	R:R:N278	6.87	No	No	1	6	6
81	R:R:L100	R:R:S76	4.5	No	No	0	4	7
82	R:R:S76	R:R:Y101	5.09	No	Yes	0	7	5
83	R:R:K80	R:R:Y101	13.14	No	Yes	1	7	5
84	R:R:F169	R:R:K80	16.13	Yes	No	1	4	7
85	R:R:L83	R:R:L93	5.54	No	No	0	5	5
86	R:R:C168	R:R:L83	4.76	No	No	0	9	5
87	R:R:Q85	R:R:S84	5.78	No	No	0	4	6
88	R:R:M167	R:R:Q87	4.08	No	No	0	3	3
89	R:R:C94	R:R:K165	4.85	No	Yes	0	9	2
90	R:R:C168	R:R:C94	7.28	No	No	0	9	9
91	R:R:E98	R:R:Y157	5.61	Yes	Yes	1	6	4
92	R:R:E98	R:R:K165	6.75	Yes	Yes	0	6	2
93	R:R:E98	R:R:F169	13.99	Yes	Yes	1	6	4
94	R:R:E98	R:R:M172	5.41	Yes	Yes	1	6	4
95	L:L:?1	R:R:E98	4.68	Yes	Yes	1	0	6
96	R:R:C99	R:R:Y157	9.41	No	Yes	0	5	4
97	R:R:F102	R:R:Y101	13.41	Yes	Yes	1	5	5
98	R:R:M105	R:R:Y101	5.99	No	Yes	0	8	5
99	R:R:F169	R:R:Y101	7.22	Yes	Yes	1	4	5
100	R:R:N278	R:R:Y101	12.79	No	Yes	1	6	5
101	R:R:F102	R:R:Y157	4.13	Yes	Yes	1	5	4
102	R:R:F102	R:R:F169	5.36	Yes	Yes	1	5	4
103	L:L:?1	R:R:F102	26.65	Yes	Yes	1	0	5
104	R:R:V103	R:R:W150	15.94	No	No	0	5	3
105	R:R:H243	R:R:Y106	5.44	Yes	No	0	8	8
106	L:L:?1	R:R:Y106	14.89	Yes	No	0	0	8
107	R:R:F239	R:R:V109	7.87	Yes	No	0	9	8
108	R:R:F110	W:W:?1	8.5	No	Yes	0	5	0
109	R:R:D284	R:R:I112	8.4	Yes	No	2	9	8
110	R:R:I112	R:R:Y288	7.25	No	Yes	2	8	9
111	R:R:F114	R:R:I138	5.02	Yes	No	0	5	8
112	R:R:F114	R:R:I141	13.82	Yes	No	0	5	5
113	R:R:I115	R:R:R119	7.52	No	No	0	8	9
114	R:R:M197	R:R:S116	4.6	No	No	0	7	9
115	R:R:C200	R:R:S116	5.16	No	No	0	7	9
116	R:R:L121	R:R:M117	8.48	No	No	0	5	5
117	R:R:D118	R:R:R133	14.29	No	Yes	0	8	7
118	R:R:R119	R:R:Y288	6.17	No	Yes	0	9	9
119	R:R:F120	R:R:R124	5.34	Yes	No	0	8	6
120	R:R:F120	R:R:F199	4.29	Yes	No	6	8	4
121	R:R:C200	R:R:F120	6.98	No	Yes	0	7	8
122	R:R:F120	R:R:R203	4.28	Yes	Yes	6	8	4
123	R:R:F120	R:R:S204	3.96	Yes	No	0	8	7
124	R:R:A122	R:R:V129	5.09	No	No	0	8	6
125	R:R:I123	R:R:I207	4.42	No	No	0	8	6
126	R:R:I123	R:R:L208	5.71	No	No	0	8	8
127	R:R:R124	R:R:Y125	21.61	No	No	0	6	6
128	R:R:L128	R:R:Y125	4.69	No	No	0	5	6
129	R:R:H131	R:R:S130	4.18	No	No	0	4	4
130	R:R:K137	R:R:S134	9.18	No	No	0	3	6
131	R:R:F139	R:R:R136	9.62	No	No	0	4	4
132	R:R:C143	R:R:F139	4.19	No	No	0	4	4
133	R:R:G152	R:R:P155	4.06	No	No	0	4	7
134	R:R:I156	R:R:L185	4.28	No	No	0	4	5
135	R:R:I156	W:W:?1	5.69	No	Yes	0	4	0
136	R:R:H160	R:R:Y157	11.98	Yes	Yes	0	5	4
137	L:L:?1	R:R:Y157	9.93	Yes	Yes	1	0	4
138	R:R:F159	R:R:S158	5.28	No	No	0	4	3
139	R:R:D175	R:R:F159	5.97	No	No	0	2	4
140	R:R:H160	R:R:K165	5.24	Yes	Yes	0	5	2
141	R:R:H160	R:R:M172	5.25	Yes	Yes	0	5	4
142	R:R:H160	R:R:T176	8.21	Yes	No	0	5	2
143	R:R:D175	R:R:K162	5.53	No	No	0	2	4
144	R:R:K165	R:R:V163	15.18	Yes	No	0	2	1
145	R:R:E164	R:R:Y166	13.47	No	No	0	1	5
146	H:H:?2	R:R:Y166	21.04	No	No	0	0	5
147	R:R:C168	R:R:F169	4.19	No	Yes	0	9	4
148	L:L:?1	R:R:F169	10.32	Yes	Yes	1	0	4
149	H:H:?1	R:R:N171	25.87	Yes	No	0	0	4
150	R:R:M172	R:R:W177	4.65	Yes	Yes	1	4	3
151	L:L:?1	R:R:M172	14.97	Yes	Yes	1	0	4
152	R:R:D175	R:R:S173	7.36	No	No	0	2	4
153	R:R:D174	R:R:R253	9.53	No	No	0	2	4
154	L:L:?1	R:R:T176	8.32	Yes	No	0	0	2
155	R:R:F182	R:R:W177	4.01	Yes	Yes	1	5	3
156	R:R:Q249	R:R:W177	5.48	Yes	Yes	1	5	3
157	R:R:R253	R:R:W177	14.99	No	Yes	0	4	3
158	L:L:?1	R:R:W177	21.71	Yes	Yes	1	0	3
159	R:R:K180	R:R:S178	4.59	No	No	0	3	4
160	R:R:K180	R:R:V181	6.07	No	No	0	3	5
161	R:R:K180	W:W:?1	16.87	No	Yes	0	3	0
162	R:R:F182	R:R:F183	9.65	Yes	No	1	5	4
163	R:R:E186	R:R:F182	8.16	No	Yes	0	5	5
164	R:R:F182	R:R:F250	24.65	Yes	No	1	5	5
165	L:L:?1	R:R:F182	4.3	Yes	Yes	1	0	5
166	R:R:F183	R:R:F250	8.57	No	No	1	4	5
167	R:R:P184	W:W:?1	6.55	No	Yes	0	4	0
168	L:L:?1	R:R:L185	4.88	Yes	No	0	0	5
169	R:R:E186	R:R:H243	11.08	No	Yes	0	5	8
170	R:R:G189	R:R:P193	4.06	No	Yes	0	6	9
171	R:R:F190	R:R:M194	6.22	Yes	No	0	9	5
172	R:R:F190	R:R:L240	6.09	Yes	No	0	9	5
173	R:R:F190	R:R:H243	24.89	Yes	Yes	0	9	8
174	R:R:L192	R:R:P193	4.93	No	Yes	0	5	9
175	R:R:I196	R:R:L192	4.28	No	No	0	6	5
176	R:R:F235	R:R:M194	6.22	No	No	0	9	5
177	R:R:M194	R:R:V236	6.09	No	No	0	5	5
178	R:R:F235	R:R:M197	11.2	No	No	0	9	7
179	R:R:F199	R:R:R203	11.76	No	Yes	6	4	4
180	R:R:C201	R:R:L232	7.94	No	No	0	8	8
181	R:R:I207	R:R:R203	7.52	No	Yes	0	6	4
182	R:R:I205	R:R:I225	5.89	Yes	No	7	4	5
183	R:R:I205	R:R:I228	5.89	Yes	No	0	4	7
184	R:R:I225	R:R:L208	4.28	No	No	0	5	8
185	R:R:Q221	R:R:R211	7.01	No	No	0	6	5
186	R:R:R212	R:R:W218	13.99	No	Yes	0	3	4
187	R:R:D217	R:R:T215	5.78	No	No	0	5	3
188	R:R:V219	R:R:W218	7.36	No	Yes	0	4	4
189	R:R:Q220	R:R:Q221	6.4	No	No	0	5	6
190	R:R:K222	R:R:Y226	11.94	No	No	0	5	5
191	R:R:S227	R:R:V291	4.85	No	No	0	7	6
192	R:R:S231	R:R:Y288	10.17	No	Yes	0	7	9
193	R:R:C287	R:R:V234	5.12	No	No	0	7	7
194	R:R:F235	R:R:F239	8.57	No	Yes	0	9	9
195	R:R:F239	R:R:S238	3.96	Yes	No	2	9	7
196	R:R:N280	R:R:S238	8.94	No	No	2	9	7
197	R:R:F239	R:R:N280	8.46	Yes	No	2	9	9
198	R:R:H243	R:R:V242	4.15	Yes	No	0	8	7
199	R:R:S273	R:R:V242	4.85	No	No	0	7	7
200	R:R:S277	R:R:V242	9.7	No	No	0	8	7
201	R:R:F246	R:R:H243	5.66	Yes	Yes	0	6	8
202	R:R:F269	R:R:L244	6.09	No	No	0	5	5
203	R:R:F246	R:R:L270	4.87	Yes	No	0	6	5
204	R:R:F246	R:R:M274	6.22	Yes	No	1	6	6
205	L:L:?1	R:R:F246	12.04	Yes	Yes	1	0	6
206	R:R:F247	R:R:L251	10.96	No	No	0	5	4
207	R:R:I266	R:R:L248	8.56	Yes	No	0	5	4
208	R:R:Q249	R:R:V252	4.3	Yes	No	1	5	3
209	R:R:I266	R:R:Q249	4.12	Yes	Yes	1	5	5
210	R:R:Q249	R:R:S267	5.78	Yes	No	0	5	4
211	R:R:L270	R:R:Q249	3.99	No	Yes	0	5	5
212	R:R:F250	R:R:N254	13.29	No	No	0	5	3
213	R:R:F256	R:R:L251	7.31	No	No	0	2	4
214	R:R:I257	R:R:L251	4.28	No	No	0	2	4
215	R:R:K263	R:R:V252	6.07	No	No	0	3	3
216	R:R:I266	R:R:V252	6.14	Yes	No	1	5	3
217	R:R:I257	R:R:I266	5.89	No	Yes	0	2	5
218	R:R:E259	R:R:R261	5.82	No	No	0	5	3
219	R:R:F276	R:R:L272	6.09	No	No	0	6	5
220	L:L:?1	R:R:M274	6.99	Yes	No	1	0	6
221	R:R:D284	R:R:N280	13.46	Yes	No	2	9	9
222	R:R:D284	R:R:Y288	5.75	Yes	Yes	2	9	9
223	R:R:V285	R:R:Y289	10.09	No	Yes	0	9	7
224	R:R:F286	R:R:F290	6.43	No	No	0	5	8
225	R:R:F295	R:R:Y289	6.19	Yes	Yes	2	8	7
226	R:R:F290	R:R:F295	6.43	No	Yes	0	8	8
227	R:R:E294	R:R:I292	5.47	No	No	0	7	7
228	R:R:K293	R:R:M297	5.76	No	No	0	6	5
229	H:H:?1	H:H:?2	39.01	Yes	No	0	0	0
230	R:R:F268	R:R:V15	3.93	No	No	0	2	5
231	R:R:F79	R:R:V97	3.93	No	No	0	6	5
232	R:R:R133	R:R:V129	3.92	Yes	No	0	7	6
233	R:R:F45	R:R:I64	3.77	Yes	No	0	7	5
234	R:R:F139	R:R:I61	3.77	No	No	0	4	6
235	R:R:F114	R:R:I145	3.77	Yes	No	0	5	6
236	R:R:T95	R:R:Y157	3.75	No	Yes	0	7	4
237	R:R:W146	R:R:W150	3.75	Yes	No	0	9	3
238	R:R:K293	R:R:R296	3.71	No	No	0	6	8
239	R:R:V68	R:R:W146	3.68	No	Yes	0	5	9
240	R:R:F31	R:R:L77	3.65	No	No	0	7	8
241	R:R:F120	R:R:L121	3.65	Yes	No	0	8	5
242	R:R:F190	R:R:L191	3.65	Yes	No	0	9	4
243	R:R:P89	R:R:S88	3.56	No	No	0	4	8
244	R:R:P135	R:R:S134	3.56	No	No	0	4	6
245	R:R:P193	R:R:V109	3.53	Yes	No	0	9	8
246	R:R:F12	R:R:Q264	3.51	No	Yes	0	5	4
247	H:H:?1	R:R:H170	3.46	Yes	No	0	0	5
248	R:R:C94	R:R:S88	3.44	No	No	0	9	8
249	R:R:C99	R:R:S153	3.44	No	No	0	5	6
250	R:R:C287	R:R:S231	3.44	No	No	0	7	7
251	R:R:C281	R:R:V74	3.42	No	No	0	8	5
252	R:R:G198	R:R:L232	3.42	No	No	0	4	8
253	R:R:G245	R:R:L248	3.42	No	No	0	5	4
254	R:R:I28	R:R:P29	3.39	No	No	0	4	4
255	R:R:I154	R:R:P155	3.39	No	No	0	4	7
256	R:R:L240	R:R:P241	3.28	No	No	0	5	9
257	R:R:C201	R:R:I228	3.27	No	No	0	8	7
258	R:R:A67	R:R:I42	3.25	No	No	0	8	7
259	R:R:S173	R:R:V163	3.23	No	No	0	4	1
260	R:R:V103	R:R:V149	3.21	No	No	0	5	7
261	R:R:T30	R:R:V279	3.17	No	No	0	7	4
262	R:R:C282	R:R:L37	3.17	No	Yes	0	7	7
263	R:R:T151	R:R:V147	3.17	No	No	0	3	4
264	R:R:I154	R:R:S153	3.1	No	No	0	4	6
265	R:R:C224	R:R:Q221	3.05	No	No	0	7	6
266	R:R:F295	R:R:G44	3.01	Yes	No	0	8	7
267	R:R:F269	R:R:G245	3.01	No	No	0	5	5
268	R:R:L49	R:R:S60	3	No	No	0	5	7
269	R:R:L283	R:R:S238	3	No	No	0	7	7
270	R:R:L35	R:R:V74	2.98	No	No	0	5	5
271	R:R:L93	R:R:V97	2.98	No	No	0	5	5
272	R:R:L283	R:R:V279	2.98	No	No	0	7	4
273	R:R:L148	R:R:T144	2.95	No	No	0	4	3
274	R:R:I138	R:R:I61	2.94	No	No	0	8	6
275	R:R:D70	R:R:S108	2.94	Yes	No	0	9	9
276	R:R:Q264	R:R:V15	2.87	Yes	No	0	4	5
277	R:R:I205	R:R:L209	2.85	Yes	No	7	4	3
278	R:R:I225	R:R:L209	2.85	No	No	7	5	3
279	R:R:L33	R:R:L37	2.77	No	Yes	0	5	7
280	R:R:A179	R:R:F183	2.77	No	No	0	3	4
281	R:R:L71	R:R:N38	2.75	No	No	0	7	9
282	R:R:N16	R:R:Q271	2.64	No	No	0	5	5
283	H:H:?1	R:R:M167	2.54	Yes	No	0	0	3
284	R:R:D213	R:R:H214	2.52	No	No	0	3	4
285	R:R:F295	R:R:I299	2.51	Yes	No	0	8	6
286	R:R:F188	R:R:L192	2.44	No	No	0	4	5
287	R:R:D213	R:R:R212	2.38	No	No	0	3	3
288	R:R:L209	R:R:W218	2.28	No	Yes	0	3	4
289	R:R:H206	R:R:R203	2.26	No	Yes	0	4	4
290	R:R:R211	R:R:W218	2	No	Yes	0	5	4
291	R:R:C281	R:R:G34	1.96	No	No	0	8	9
292	R:R:C282	R:R:G34	1.96	No	No	0	7	9
293	R:R:C143	R:R:G140	1.96	No	No	0	4	1
294	R:R:C113	R:R:P193	1.88	No	Yes	0	7	9
295	R:R:G44	R:R:T47	1.82	No	No	0	7	3
296	R:R:A230	R:R:C287	1.81	No	No	0	5	7
297	R:R:A262	R:R:S265	1.71	No	No	0	1	3
298	R:R:A229	R:R:I205	1.62	No	Yes	0	3	4
299	R:R:A262	R:R:I257	1.62	No	No	0	1	2
300	R:R:V82	R:R:V86	1.6	No	No	0	4	4
301	R:R:I42	R:R:S46	1.55	No	No	0	7	3
302	R:R:I64	R:R:S46	1.55	No	No	0	5	3
303	R:R:I292	R:R:V291	1.54	No	No	0	7	6
304	R:R:C260	R:R:Q264	1.53	No	Yes	0	7	4
305	R:R:A262	R:R:E259	1.51	No	No	0	1	5
306	R:R:K20	R:R:T21	1.5	No	No	0	5	3
307	R:R:G210	R:R:R212	1.5	No	No	0	5	3
308	R:R:L33	R:R:V32	1.49	No	No	0	5	5
309	R:R:L36	R:R:V32	1.49	No	No	0	4	5
310	R:R:L83	R:R:V82	1.49	No	No	0	5	4
311	R:R:L191	R:R:V187	1.49	No	No	0	4	4
312	R:R:D9	R:R:V258	1.46	No	No	0	6	2
313	R:R:F90	R:R:P89	1.44	No	No	0	6	4
314	R:R:F90	R:R:P91	1.44	No	No	0	6	6
315	R:R:K50	R:R:N51	1.4	No	No	0	5	5
316	R:R:P126	R:R:Y125	1.39	No	No	0	8	6
317	R:R:L35	R:R:L75	1.38	No	No	0	5	4
318	R:R:L71	R:R:L75	1.38	No	No	0	7	4
319	R:R:L93	R:R:L96	1.38	No	No	0	5	4
320	R:R:L127	R:R:L128	1.38	No	No	0	5	5
321	R:R:E294	R:R:K293	1.35	No	No	0	7	6
322	R:R:L11	R:R:Q264	1.33	No	Yes	0	4	4
323	R:R:R203	R:R:S202	1.32	Yes	No	0	4	3
324	R:R:H131	R:R:L132	1.29	No	No	0	4	4
325	R:R:R211	R:R:T215	1.29	No	No	0	5	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:M19	7.0725	4	3	5
2	R:R:Q23	4.805	4	1	5
3	R:R:H27	7.89167	6	1	7
4	R:R:L37	4.565	4	0	7
5	R:R:F45	7.21	5	2	7
6	R:R:Y62	10.302	5	2	8
7	R:R:M63	7.805	4	2	8
8	R:R:N65	9.3125	4	5	9
9	R:R:L66	7.045	4	2	9
10	R:R:D70	6.25	4	0	9
11	R:R:M81	5.675	4	1	7
12	R:R:E98	7.288	5	1	6
13	R:R:Y101	8.90429	7	1	5
14	R:R:F102	12.3875	4	1	5
15	R:R:F114	7.9725	4	0	5
16	R:R:F120	4.75	6	6	8
17	R:R:R133	7.2275	4	0	7
18	R:R:W146	11.4475	4	5	9
19	R:R:Y157	7.46833	6	1	4
20	R:R:H160	7.67	4	0	5
21	R:R:K165	8.005	4	0	2
22	R:R:F169	9.535	6	1	4
23	R:R:M172	7.57	4	1	4
24	R:R:W177	10.168	5	1	3
25	R:R:F182	10.154	5	1	5
26	R:R:F190	10.2125	4	0	9
27	R:R:P193	3.6	4	0	9
28	R:R:R203	5.428	5	6	4
29	R:R:I205	4.0625	4	7	4
30	R:R:W218	6.4075	4	0	4
31	R:R:F239	7.215	4	2	9
32	R:R:H243	10.244	5	0	8
33	R:R:F246	7.1975	4	1	6
34	R:R:Q249	4.734	5	1	5
35	R:R:Q264	2.31	4	0	4
36	R:R:I266	6.1775	4	1	5
37	R:R:D284	9.284	5	2	9
38	R:R:Y288	7.335	4	2	9
39	R:R:Y289	6.48286	7	2	7
40	R:R:F295	4.7	5	2	8
41	H:H:?1	17.72	4	0	0
42	L:L:?1	11.64	12	1	0
43	W:W:?1	9.4025	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F12	R:R:S267	19.8881	6.61	No	No	0	5	4
2	R:R:Q249	R:R:S267	20.5082	5.78	Yes	No	0	5	4
3	R:R:F12	R:R:Q264	18.5179	3.51	No	Yes	0	5	4
4	R:R:Q264	R:R:V15	14.2998	2.87	Yes	No	0	4	5
5	R:R:F268	R:R:V15	13.5811	3.93	No	No	0	2	5
6	R:R:F268	R:R:M19	11.3512	6.22	No	Yes	0	2	5
7	R:R:Q249	R:R:W177	12.5378	5.48	Yes	Yes	1	5	3
8	L:L:?1	R:R:W177	11.781	21.71	Yes	Yes	1	0	3
9	L:L:?1	R:R:F169	44.9144	10.32	Yes	Yes	1	0	4
10	R:R:F169	R:R:K80	24.2315	16.13	Yes	No	1	4	7
11	R:R:H27	R:R:K80	23.777	11.79	Yes	No	1	7	7
12	R:R:H27	R:R:Q23	10.6683	4.95	Yes	Yes	1	7	5
13	R:R:L270	R:R:Q249	19.3955	3.99	No	Yes	0	5	5
14	R:R:F246	R:R:L270	19.9172	4.87	Yes	No	0	6	5
15	R:R:F246	R:R:H243	58.3768	5.66	Yes	Yes	0	6	8
16	R:R:F190	R:R:H243	100	24.89	Yes	Yes	0	9	8
17	R:R:F190	R:R:M194	99.2164	6.22	Yes	No	0	9	5
18	R:R:F235	R:R:M194	98.8716	6.22	No	No	0	9	5
19	R:R:F235	R:R:F239	88.3421	8.57	No	Yes	0	9	9
20	R:R:F239	R:R:N280	82.6464	8.46	Yes	No	2	9	9
21	R:R:D284	R:R:N280	83.3359	13.46	Yes	No	2	9	9
22	R:R:D284	R:R:L66	52.7393	9.5	Yes	Yes	2	9	9
23	R:R:L66	R:R:Y289	47.0883	7.03	Yes	Yes	2	9	7
24	R:R:D284	R:R:D70	12.9139	9.31	Yes	Yes	0	9	9
25	R:R:F45	R:R:Y289	18.0902	9.28	Yes	Yes	2	7	7
26	R:R:F45	R:R:S60	17.5798	3.96	Yes	No	0	7	7
27	R:R:M63	R:R:Y289	17.3268	4.79	Yes	Yes	2	8	7
28	R:R:F48	R:R:S60	15.8916	3.96	No	No	0	6	7
29	R:R:F48	R:R:R52	14.1968	8.55	No	No	0	6	6
30	R:R:M63	R:R:Y62	17.8887	8.38	Yes	Yes	2	8	8
31	R:R:F114	R:R:I138	11.1519	5.02	Yes	No	0	5	8
32	R:R:F114	R:R:Y62	15.8849	9.28	Yes	Yes	0	5	8
33	R:R:I115	R:R:Y62	14.92	15.71	No	Yes	2	8	8
34	R:R:I115	R:R:R119	15.9521	7.52	No	No	0	8	9
35	R:R:R119	R:R:Y288	16.5275	6.17	No	Yes	0	9	9
36	R:R:D284	R:R:Y288	20.1702	5.75	Yes	Yes	2	9	9
37	R:R:C168	R:R:F169	14.2125	4.19	No	Yes	0	9	4
38	R:R:E98	R:R:K165	13.8744	6.75	Yes	Yes	0	6	2
39	L:L:?1	R:R:E98	12.6632	4.68	Yes	Yes	1	0	6
40	L:L:?1	R:R:Y106	38.332	14.89	Yes	No	0	0	8
41	R:R:F235	R:R:M197	33.8565	11.2	No	No	0	9	7
42	R:R:M197	R:R:S116	33.0684	4.6	No	No	0	7	9
43	R:R:C200	R:R:S116	32.2758	5.16	No	No	0	7	9
44	R:R:C200	R:R:F120	31.4788	6.98	No	Yes	0	7	8
45	R:R:F120	R:R:R203	23.2039	4.28	Yes	Yes	6	8	4
46	R:R:I207	R:R:R203	20.7097	7.52	No	Yes	0	6	4
47	R:R:I123	R:R:I207	19.8478	4.42	No	No	0	8	6
48	R:R:I123	R:R:L208	18.9768	5.71	No	No	0	8	8
49	R:R:I225	R:R:L208	18.1059	4.28	No	No	0	5	8
50	R:R:I225	R:R:L209	11.8661	2.85	No	No	7	5	3
51	R:R:L209	R:R:W218	11.1318	2.28	No	Yes	0	3	4
52	R:R:H243	R:R:Y106	38.4708	5.44	Yes	No	0	8	8
53	L:L:?1	R:R:F246	38.4484	12.04	Yes	Yes	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:K80	R:R:Y101	13.14	1	No	Yes	7	5	2	2
R:R:F169	R:R:K80	16.13	1	Yes	No	4	7	1	2
R:R:E98	R:R:Y157	5.61	1	Yes	Yes	6	4	1	1
R:R:E98	R:R:K165	6.75	1	Yes	Yes	6	2	1	2
R:R:E98	R:R:F169	13.99	1	Yes	Yes	6	4	1	1
R:R:E98	R:R:M172	5.41	1	Yes	Yes	6	4	1	1
L:L:?1	R:R:E98	4.68	1	Yes	Yes	0	6	0	1
R:R:C99	R:R:Y157	9.41	0	No	Yes	5	4	2	1
R:R:F102	R:R:Y101	13.41	1	Yes	Yes	5	5	1	2
R:R:F169	R:R:Y101	7.22	1	Yes	Yes	4	5	1	2
R:R:F102	R:R:Y157	4.13	1	Yes	Yes	5	4	1	1
R:R:F102	R:R:F169	5.36	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:F102	26.65	1	Yes	Yes	0	5	0	1
R:R:H243	R:R:Y106	5.44	0	Yes	No	8	8	2	1
L:L:?1	R:R:Y106	14.89	1	Yes	No	0	8	0	1
R:R:I156	R:R:L185	4.28	0	No	No	4	5	2	1
R:R:H160	R:R:Y157	11.98	0	Yes	Yes	5	4	2	1
L:L:?1	R:R:Y157	9.93	1	Yes	Yes	0	4	0	1
R:R:H160	R:R:K165	5.24	0	Yes	Yes	5	2	2	2
R:R:H160	R:R:M172	5.25	0	Yes	Yes	5	4	2	1
R:R:H160	R:R:T176	8.21	0	Yes	No	5	2	2	1
R:R:C168	R:R:F169	4.19	0	No	Yes	9	4	2	1
L:L:?1	R:R:F169	10.32	1	Yes	Yes	0	4	0	1
R:R:M172	R:R:W177	4.65	1	Yes	Yes	4	3	1	1
L:L:?1	R:R:M172	14.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T176	8.32	1	Yes	No	0	2	0	1
R:R:F182	R:R:W177	4.01	1	Yes	Yes	5	3	1	1
R:R:Q249	R:R:W177	5.48	1	Yes	Yes	5	3	2	1
R:R:R253	R:R:W177	14.99	0	No	Yes	4	3	2	1
L:L:?1	R:R:W177	21.71	1	Yes	Yes	0	3	0	1
R:R:F182	R:R:F183	9.65	1	Yes	No	5	4	1	2
R:R:E186	R:R:F182	8.16	0	No	Yes	5	5	2	1
R:R:F182	R:R:F250	24.65	1	Yes	No	5	5	1	2
L:L:?1	R:R:F182	4.3	1	Yes	Yes	0	5	0	1
R:R:F183	R:R:F250	8.57	1	No	No	4	5	2	2
L:L:?1	R:R:L185	4.88	1	Yes	No	0	5	0	1
R:R:E186	R:R:H243	11.08	0	No	Yes	5	8	2	2
R:R:F246	R:R:H243	5.66	1	Yes	Yes	6	8	1	2
R:R:F246	R:R:L270	4.87	1	Yes	No	6	5	1	2
R:R:F246	R:R:M274	6.22	1	Yes	No	6	6	1	1
L:L:?1	R:R:F246	12.04	1	Yes	Yes	0	6	0	1
R:R:L270	R:R:Q249	3.99	0	No	Yes	5	5	2	2
L:L:?1	R:R:M274	6.99	1	Yes	No	0	6	0	1
R:R:T95	R:R:Y157	3.75	0	No	Yes	7	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F110	W:W:?1	8.5	No	Yes	5	0	1	0
R:R:I156	R:R:L185	4.28	No	No	4	5	1	2
R:R:I156	W:W:?1	5.69	No	Yes	4	0	1	0
R:R:K180	R:R:S178	4.59	No	No	3	4	1	2
R:R:K180	R:R:V181	6.07	No	No	3	5	1	2
R:R:K180	W:W:?1	16.87	No	Yes	3	0	1	0
R:R:P184	W:W:?1	6.55	No	Yes	4	0	1	0

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GE2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.96
Number of Linked Nodes	286
Number of Links	325
Number of Hubs	43
Number of Links mediated by Hubs	163
Number of Communities	7
Number of Nodes involved in Communities	51
Number of Links involved in Communities	71

Path Summary
Number Of Nodes in MetaPath	54
Number Of Links MetaPath	53
Number of Shortest Paths	71590
Length Of Smallest Path	3
Average Path Length	15.5413
Length of Longest Path	35
Minimum Path Strength	1.38
Average Path Strength	8.14862
Maximum Path Strength	32.44
Minimum Path Correlation	0.7
Average Path Correlation	0.929245
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	47.0134
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0145
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • hydrolase activity • GDP binding • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides • catalytic activity • pyrophosphatase activity • GTPase activity • nucleoside-triphosphatase regulator activity • GTPase regulator activity • guanyl-nucleotide exchange factor activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • circulatory system process • regulation of blood pressure • blood circulation • developmental process • cellular developmental process • cell differentiation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of vascular associated smooth muscle cell migration • negative regulation of locomotion • vascular associated smooth muscle cell migration • regulation of cell motility • negative regulation of vascular associated smooth muscle cell migration • regulation of smooth muscle cell migration • negative regulation of biological process • smooth muscle cell migration • muscle cell migration • negative regulation of smooth muscle cell migration • regulation of locomotion • regulation of cell migration • negative regulation of cellular process • negative regulation of cell motility • cell migration • cell motility • locomotion • negative regulation of cell migration • regulation of fibroblast migration • fibroblast migration • ameboidal-type cell migration • multicellular organism development • embryo development ending in birth or egg hatching • chordate embryonic development • anatomical structure development • embryo development • in utero embryonic development • adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of developmental process • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • system development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • regulation of signaling • small GTPase-mediated signal transduction • regulation of small GTPase mediated signal transduction • regulation of signal transduction • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • regulation of cell communication • Rho protein signal transduction • regulation of vascular associated smooth muscle cell proliferation • negative regulation of cell population proliferation • cell population proliferation • regulation of smooth muscle cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • smooth muscle cell proliferation • negative regulation of smooth muscle cell proliferation • regulation of cell population proliferation • muscle cell proliferation • vascular associated smooth muscle cell proliferation • cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle
Gene Ontology	Cellular Component	• cellular anatomical structure • anchoring junction • cell junction • focal adhesion • cell-substrate junction • membrane • membrane-bounded organelle • intracellular anatomical structure • pigment granule • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • melanosome • cytoplasmic vesicle • organelle • cytoplasm • vesicle • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • brush border membrane • cluster of actin-based cell projections • plasma membrane bounded cell projection • brush border • cell projection • plasma membrane region • cell projection membrane • postsynapse • synapse • nucleus • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • G-protein beta-subunit binding • fibroblast proliferation • cannabinoid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • positive regulation of cell communication • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of biological process • regulation of signal transduction • Rho protein signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • myeloid leukocyte differentiation • regulation of leukocyte differentiation • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • cell differentiation • osteoclast differentiation • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • multicellular organismal-level homeostasis • homeostatic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NAG
PDB Residues	H:H:?1 H:H:?2
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetyl-D-glucosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


Code	A1I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1I
Name	N-(cyclopent-3-ene-1-carbonyl)-L-histidine
Synonyms
Identifier
Formula	C12 H15 N3 O3
Molecular Weight	249.266
SMILES
PubChem	64766902
Formal Charge	0
Total Atoms	33
Total Chiral Atoms	1
Total Bonds	34
Total Aromatic Bonds	5


Code	CLR
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	CLR
Name	Cholesterol
Synonyms	Cholesterin Cholesterol Cholest-5-en-3beta-ol (3β,14β,17α)-cholest-5-en-3-ol
Identifier
Formula	C27 H46 O
Molecular Weight	386.654
SMILES
PubChem	5997
Formal Charge	0
Total Atoms	74
Total Chiral Atoms	8
Total Bonds	77
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T6
Sequence	>9GE2_nogp_Chain_R D C L F D G V N E L M K T L Q F A V H I P T F V L G L L L N L L A I H G F S T F L K N R W P D Y A A T S I Y M I N L A V F D L L L V L S L P F K M V L S Q V Q S P F P S L C T L V E C L Y F V S M Y G S V F T I C F I S M D R F L A I R Y P L L V S H L R S P R K I F G I C C T I W V L V W T G S I P I Y S F H G K V E K Y M C F H N M S D D T W S A K V F F P L E V F G F L L P M G I M G F C C S R S I H I L L G R R D H T Q D W V Q Q K A C I Y S I A A S L A V F V V S F L P V H L G F F L Q F L V R N S F I V E C R A K Q S I S F F L Q L S M C F S N V N C C L D V F C Y Y F V I K E F R M N I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9GE3	A	Orphan	Orphan	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(CtGi1-G13)/β1/γ2	2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE3 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	Lysophosphatidylinositol	-		2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE2	A	Orphan	Orphan	GPR55	Homo sapiens	ML184	Cholesterol	chim(CtGi1-G13)/β1/γ2	2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE2 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	ML184	Cholesterol		2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9IY8	A	Orphan	Orphan	GPR55	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IY8 (No Gprot)	A	Orphan	Orphan	GPR55	Homo sapiens	-	-		3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IYA	A	Lipid	GPR55	GPR55	Homo sapiens	ONO-9710531	-	-	3.04	2025-01-01	10.1038/s41422-024-01046-8
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	10.1038/s41422-024-01044-w
	8ZX4	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(NtGi1-G13)/β1/γ2	3.03	2024-11-13	10.1038/s41422-024-01044-w
	8ZX4 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-		3.03	2024-11-13	10.1038/s41422-024-01044-w

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9GE2_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.