psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C10	R:R:F12	5.59	Yes	No	0	8	5
2	R:R:C10	R:R:K263	4.85	Yes	No	0	8	3
3	R:R:C10	R:R:Q264	7.63	Yes	No	0	8	4
4	R:R:D13	R:R:L11	5.43	No	No	0	3	4
5	R:R:F12	R:R:S267	3.96	No	No	1	5	4
6	L:L:?1	R:R:F12	13.77	Yes	No	1	0	5
7	R:R:F268	R:R:V15	3.93	No	No	0	2	5
8	L:L:?1	R:R:N16	6.04	Yes	No	0	0	5
9	R:R:E17	R:R:K20	5.4	No	No	0	3	5
10	R:R:F268	R:R:L18	6.09	No	No	0	2	4
11	R:R:L22	R:R:M19	4.24	No	Yes	0	5	5
12	R:R:M19	R:R:Q23	4.08	Yes	No	3	5	5
13	R:R:F268	R:R:M19	4.98	No	Yes	0	2	5
14	R:R:M19	R:R:Q271	20.39	Yes	No	3	5	5
15	R:R:Q23	R:R:S84	4.33	No	No	0	5	6
16	R:R:Q23	R:R:Q271	5.12	No	No	3	5	5
17	R:R:F24	R:R:Q85	9.37	No	No	0	5	4
18	R:R:C275	R:R:V26	5.12	No	No	0	5	5
19	R:R:C275	R:R:H27	11.79	No	No	0	5	7
20	R:R:H27	R:R:N278	12.75	No	Yes	0	7	6
21	R:R:I28	R:R:M81	5.83	No	No	0	4	7
22	R:R:T30	R:R:V279	6.35	No	No	0	7	4
23	R:R:F31	R:R:L35	6.09	Yes	Yes	0	7	5
24	R:R:F31	R:R:P78	13	Yes	No	0	7	9
25	R:R:L35	R:R:V74	4.47	Yes	No	0	5	5
26	R:R:L37	R:R:V285	10.43	No	No	0	7	9
27	R:R:D70	R:R:N38	9.42	Yes	No	0	9	9
28	R:R:L71	R:R:N38	4.12	No	No	0	7	9
29	R:R:L39	R:R:L71	5.54	No	No	0	3	7
30	R:R:I299	R:R:L40	4.28	No	No	0	6	5
31	R:R:A41	R:R:Y289	4	No	Yes	0	9	7
32	R:R:F45	R:R:F48	4.29	Yes	No	0	7	6
33	R:R:F45	R:R:M63	7.46	Yes	Yes	2	7	8
34	R:R:F45	R:R:Y289	4.13	Yes	Yes	2	7	7
35	R:R:F295	R:R:F45	8.57	No	Yes	0	8	7
36	R:R:K50	R:R:S46	4.59	No	No	0	5	3
37	R:R:N51	R:R:T47	4.39	No	No	0	5	3
38	R:R:N298	R:R:T47	7.31	No	No	0	5	3
39	R:R:F48	R:R:R52	5.34	No	No	0	6	6
40	R:R:F48	R:R:N298	7.25	No	No	0	6	5
41	R:R:K50	R:R:N51	4.2	No	No	0	5	5
42	R:R:P54	R:R:W53	5.4	No	No	0	6	5
43	R:R:A57	R:R:W53	7.78	No	No	0	7	5
44	R:R:P135	R:R:W53	4.05	No	No	0	4	5
45	R:R:D55	R:R:P54	4.83	No	No	0	6	6
46	R:R:D55	R:R:Y56	5.75	No	No	0	6	4
47	R:R:E294	R:R:Y56	14.59	No	No	0	7	4
48	R:R:A58	R:R:R133	4.15	No	No	0	7	7
49	R:R:T59	R:R:Y62	11.24	No	Yes	0	7	8
50	R:R:I138	R:R:I61	4.42	No	No	0	8	6
51	R:R:M63	R:R:Y62	4.79	Yes	Yes	2	8	8
52	R:R:F114	R:R:Y62	8.25	No	Yes	0	5	8
53	R:R:I115	R:R:Y62	6.04	No	Yes	2	8	8
54	R:R:D118	R:R:Y62	10.34	No	Yes	2	8	8
55	R:R:R133	R:R:Y62	4.12	No	Yes	2	7	8
56	R:R:I138	R:R:Y62	4.84	No	Yes	0	8	8
57	R:R:I115	R:R:M63	4.37	No	Yes	2	8	8
58	R:R:M63	R:R:Y289	4.79	Yes	Yes	2	8	7
59	R:R:F69	R:R:N65	8.46	No	Yes	4	8	9
60	R:R:N65	R:R:T111	7.31	Yes	No	0	9	8
61	R:R:C142	R:R:N65	7.87	No	Yes	0	6	9
62	R:R:N65	R:R:W146	10.17	Yes	No	4	9	9
63	R:R:L66	R:R:T111	7.37	Yes	No	0	9	8
64	R:R:I112	R:R:L66	5.71	Yes	Yes	2	8	9
65	R:R:D284	R:R:L66	6.79	Yes	Yes	2	9	9
66	R:R:L66	R:R:Y289	4.69	Yes	Yes	2	9	7
67	R:R:A67	R:R:Y289	4	No	Yes	0	8	7
68	R:R:F69	R:R:G107	7.53	No	No	0	8	7
69	R:R:F69	R:R:W146	23.05	No	No	4	8	9
70	R:R:C281	R:R:D70	10.89	No	Yes	0	8	9
71	R:R:D284	R:R:D70	5.32	Yes	Yes	0	9	9
72	R:R:L100	R:R:L72	4.15	No	No	0	4	7
73	R:R:L72	R:R:S104	6.01	No	No	0	7	9
74	R:R:L73	R:R:S104	6.01	No	No	0	6	9
75	R:R:L73	R:R:N278	4.12	No	Yes	0	6	6
76	R:R:C281	R:R:L73	4.76	No	No	0	8	6
77	R:R:L100	R:R:S76	4.5	No	No	0	4	7
78	R:R:S76	R:R:Y101	6.36	No	Yes	0	7	5
79	R:R:L77	R:R:Y101	4.69	No	Yes	1	8	5
80	R:R:L77	R:R:N278	4.12	No	Yes	1	8	6
81	R:R:F79	R:R:V97	6.55	No	No	0	6	5
82	R:R:K80	R:R:Y101	15.53	No	Yes	1	7	5
83	R:R:F169	R:R:K80	19.85	Yes	No	1	4	7
84	R:R:C168	R:R:L83	4.76	No	No	0	9	5
85	R:R:Q87	R:R:Y166	12.4	No	No	0	3	5
86	R:R:F90	R:R:L93	4.87	No	No	0	6	5
87	R:R:C94	R:R:E98	6.08	No	No	0	9	6
88	R:R:C168	R:R:C94	7.28	No	No	0	9	9
89	R:R:E98	R:R:H160	9.85	No	Yes	0	6	5
90	R:R:E98	R:R:F169	10.49	No	Yes	0	6	4
91	R:R:C99	R:R:Y157	6.72	No	Yes	0	5	4
92	R:R:F102	R:R:Y101	6.19	No	Yes	1	5	5
93	R:R:F169	R:R:Y101	6.19	Yes	Yes	1	4	5
94	R:R:N278	R:R:Y101	11.63	Yes	Yes	1	6	5
95	R:R:F102	R:R:Y157	11.35	No	Yes	1	5	4
96	L:L:?1	R:R:F102	12.24	Yes	No	1	0	5
97	R:R:V103	R:R:V149	4.81	No	No	0	5	7
98	R:R:V103	R:R:W150	4.9	No	No	0	5	3
99	R:R:M105	R:R:Y106	5.99	No	Yes	0	8	8
100	R:R:L185	R:R:Y106	9.38	No	Yes	1	5	8
101	R:R:H243	R:R:Y106	5.44	No	Yes	0	8	8
102	L:L:?1	R:R:Y106	11.79	Yes	Yes	1	0	8
103	R:R:F239	R:R:V109	5.24	No	No	0	9	8
104	R:R:I112	R:R:M197	4.37	Yes	Yes	0	8	7
105	R:R:D284	R:R:I112	5.6	Yes	Yes	2	9	8
106	R:R:I112	R:R:Y288	8.46	Yes	Yes	2	8	9
107	R:R:C113	R:R:I196	4.91	No	No	0	7	6
108	R:R:F114	R:R:I141	15.07	No	No	0	5	5
109	R:R:I115	R:R:R119	6.26	No	No	0	8	9
110	R:R:M197	R:R:S116	6.13	Yes	No	0	7	9
111	R:R:C200	R:R:S116	5.16	No	No	0	7	9
112	R:R:L121	R:R:M117	4.24	No	No	0	5	5
113	R:R:C200	R:R:M117	4.86	No	No	0	7	5
114	R:R:D118	R:R:R133	11.91	No	No	2	8	7
115	R:R:R119	R:R:Y288	6.17	No	Yes	0	9	9
116	R:R:F120	R:R:R124	5.34	No	No	0	8	6
117	R:R:C200	R:R:F120	6.98	No	No	0	7	8
118	R:R:I123	R:R:S204	4.64	No	No	0	8	7
119	R:R:I123	R:R:I207	4.42	No	No	0	8	6
120	R:R:R124	R:R:Y125	20.58	No	No	0	6	6
121	R:R:K137	R:R:S134	7.65	No	No	0	3	6
122	R:R:K137	R:R:R136	6.19	No	No	0	3	4
123	R:R:I154	R:R:W150	4.7	No	No	0	4	3
124	R:R:S153	R:R:Y157	10.17	No	Yes	0	6	4
125	R:R:I154	R:R:P155	5.08	No	No	0	4	7
126	R:R:I156	R:R:Y157	4.84	No	Yes	0	4	4
127	R:R:H160	R:R:Y157	7.62	Yes	Yes	1	5	4
128	L:L:?1	R:R:Y157	8.84	Yes	Yes	1	0	4
129	R:R:F159	R:R:S158	5.28	No	No	0	4	3
130	R:R:H160	R:R:M172	13.13	Yes	No	1	5	4
131	R:R:H160	R:R:T176	8.21	Yes	No	1	5	2
132	R:R:C168	R:R:F169	4.19	No	Yes	0	9	4
133	R:R:H170	R:R:Q271	4.95	No	No	0	5	5
134	L:L:?1	R:R:H170	8.08	Yes	No	0	0	5
135	H:H:?1	R:R:N171	27.11	No	No	0	0	4
136	R:R:M172	R:R:T176	4.52	No	No	1	4	2
137	R:R:S173	R:R:T176	4.8	No	No	0	4	2
138	R:R:Q249	R:R:W177	5.48	Yes	No	1	5	3
139	R:R:R253	R:R:W177	11	Yes	No	1	4	3
140	L:L:?1	R:R:W177	10.73	Yes	No	1	0	3
141	R:R:A179	R:R:F183	4.16	No	No	0	3	4
142	R:R:E186	R:R:F182	9.33	No	No	0	5	5
143	R:R:F182	R:R:F250	25.72	No	No	0	5	5
144	R:R:F183	R:R:F250	4.29	No	No	0	4	5
145	L:L:?1	R:R:L185	9.57	Yes	No	1	0	5
146	R:R:E186	R:R:H243	11.08	No	No	0	5	8
147	R:R:F188	R:R:V187	3.93	No	No	0	4	4
148	R:R:G189	R:R:P193	4.06	No	No	0	6	9
149	R:R:F190	R:R:L191	4.87	Yes	No	0	9	4
150	R:R:F190	R:R:M194	4.98	Yes	No	0	9	5
151	R:R:F190	R:R:H243	15.84	Yes	No	0	9	8
152	R:R:L192	R:R:P193	4.93	No	No	0	5	9
153	R:R:M194	R:R:V236	4.56	No	No	0	5	5
154	R:R:F235	R:R:M197	8.71	No	Yes	0	9	7
155	R:R:F199	R:R:R203	11.76	No	Yes	0	4	4
156	R:R:C201	R:R:L232	9.52	No	No	0	8	8
157	R:R:H206	R:R:R203	5.64	No	Yes	0	4	4
158	R:R:I207	R:R:R203	6.26	No	Yes	0	6	4
159	R:R:I205	R:R:I225	4.42	No	No	0	4	5
160	R:R:I205	R:R:I228	5.89	No	No	0	4	7
161	R:R:Q221	R:R:R211	4.67	No	No	0	6	5
162	R:R:Q216	R:R:R212	9.35	No	No	0	5	3
163	R:R:R212	R:R:W218	9	No	No	0	3	4
164	R:R:D213	R:R:H214	11.35	No	No	0	3	4
165	R:R:D217	R:R:T215	4.34	No	No	0	5	3
166	R:R:K222	R:R:V219	6.07	No	No	0	5	4
167	R:R:Q220	R:R:Q221	5.12	No	No	0	5	6
168	R:R:C224	R:R:Q221	4.58	No	No	0	7	6
169	R:R:S227	R:R:V291	6.46	No	No	0	7	6
170	R:R:S231	R:R:Y288	8.9	No	Yes	0	7	9
171	R:R:C287	R:R:V234	5.12	No	No	0	7	7
172	R:R:F235	R:R:F239	11.79	No	No	0	9	9
173	R:R:S238	R:R:V237	4.85	No	No	0	7	5
174	R:R:N280	R:R:S238	4.47	No	No	0	9	7
175	R:R:F239	R:R:N280	8.46	No	No	0	9	9
176	R:R:L240	R:R:P241	6.57	No	No	0	5	9
177	R:R:F246	R:R:V242	3.93	No	No	0	6	7
178	R:R:S273	R:R:V242	8.08	No	No	0	7	7
179	R:R:L244	R:R:L248	4.15	No	No	0	5	4
180	R:R:F246	R:R:L270	6.09	No	No	0	6	5
181	R:R:F246	R:R:M274	6.22	No	No	0	6	6
182	R:R:F247	R:R:L251	10.96	No	No	0	5	4
183	R:R:I266	R:R:L248	4.28	No	No	0	5	4
184	R:R:Q249	R:R:V252	4.3	Yes	No	0	5	3
185	R:R:L270	R:R:Q249	7.99	No	Yes	0	5	5
186	L:L:?1	R:R:Q249	4.18	Yes	Yes	1	0	5
187	R:R:F250	R:R:N254	8.46	No	No	0	5	3
188	R:R:F256	R:R:L251	4.87	No	No	0	2	4
189	R:R:I257	R:R:V252	7.68	No	No	0	2	3
190	R:R:K263	R:R:V252	4.55	No	No	0	3	3
191	L:L:?1	R:R:R253	5.34	Yes	Yes	1	0	4
192	R:R:C260	R:R:Q264	6.1	No	No	0	7	4
193	L:L:?1	R:R:S267	4.72	Yes	No	1	0	4
194	R:R:F276	R:R:L272	6.09	No	No	0	6	5
195	L:L:?1	R:R:M274	4.44	Yes	No	0	0	6
196	R:R:D284	R:R:N280	12.12	Yes	No	0	9	9
197	R:R:D284	R:R:Y288	4.6	Yes	Yes	2	9	9
198	R:R:V285	R:R:Y289	6.31	No	Yes	0	9	7
199	R:R:F290	R:R:V285	3.93	No	No	0	8	9
200	R:R:F286	R:R:F290	7.5	No	No	0	5	8
201	R:R:C287	R:R:Y288	6.72	No	Yes	0	7	9
202	R:R:F290	R:R:F295	5.36	No	No	0	8	8
203	R:R:E294	R:R:I292	4.1	No	No	0	7	7
204	R:R:K293	R:R:M297	8.64	No	No	0	6	5
205	R:R:F295	R:R:I299	15.07	No	No	0	8	6
206	R:R:C99	R:R:W150	3.92	No	No	0	5	3
207	R:R:F45	R:R:I292	3.77	Yes	No	0	7	7
208	R:R:I207	R:R:R124	3.76	No	No	0	6	6
209	R:R:K293	R:R:R296	3.71	No	No	0	6	8
210	R:R:F31	R:R:L77	3.65	Yes	No	0	7	8
211	R:R:F190	R:R:L240	3.65	Yes	No	0	9	5
212	R:R:P89	R:R:S88	3.56	No	No	0	4	8
213	R:R:P135	R:R:S134	3.56	No	No	0	4	6
214	R:R:P193	R:R:V109	3.53	No	No	0	9	8
215	R:R:G198	R:R:L232	3.42	No	No	0	4	8
216	R:R:L209	R:R:W218	3.42	No	No	0	3	4
217	R:R:G245	R:R:L248	3.42	No	No	0	5	4
218	R:R:G245	R:R:L270	3.42	No	No	0	5	5
219	R:R:I28	R:R:P29	3.39	No	No	0	4	4
220	R:R:C201	R:R:I228	3.27	No	No	0	8	7
221	R:R:A67	R:R:I42	3.25	No	No	0	8	7
222	R:R:S277	R:R:V242	3.23	No	No	0	8	7
223	R:R:I156	R:R:V181	3.07	No	No	0	4	5
224	R:R:K20	R:R:T21	3	No	No	0	5	3
225	R:R:L49	R:R:S60	3	No	No	0	5	7
226	R:R:L191	R:R:V187	2.98	No	No	0	4	4
227	R:R:D70	R:R:S108	2.94	Yes	No	0	9	9
228	R:R:F90	R:R:P91	2.89	No	No	0	6	6
229	R:R:I123	R:R:L208	2.85	No	No	0	8	8
230	R:R:I196	R:R:L192	2.85	No	No	0	6	5
231	R:R:I225	R:R:L209	2.85	No	No	0	5	3
232	R:R:L272	R:R:M19	2.83	No	Yes	0	5	5
233	R:R:K50	R:R:L49	2.82	No	No	0	5	5
234	R:R:H131	R:R:S130	2.79	No	No	0	4	4
235	R:R:C143	R:R:F139	2.79	No	No	0	4	4
236	R:R:L35	R:R:L75	2.77	Yes	No	0	5	4
237	R:R:L71	R:R:L75	2.77	No	No	0	7	4
238	R:R:F31	R:R:V32	2.62	Yes	No	0	7	5
239	R:R:F169	R:R:V97	2.62	Yes	No	0	4	5
240	R:R:F110	R:R:V109	2.62	No	No	0	5	8
241	R:R:F110	R:R:V149	2.62	No	No	0	5	7
242	R:R:F139	R:R:I61	2.51	No	No	0	4	6
243	R:R:F114	R:R:I145	2.51	No	No	0	5	6
244	R:R:F24	R:R:K20	2.48	No	No	0	5	5
245	R:R:V68	R:R:W146	2.45	No	No	0	5	9
246	R:R:K222	R:R:Y226	2.39	No	No	0	5	5
247	R:R:R211	R:R:W218	2	No	No	0	5	4
248	R:R:C282	R:R:G34	1.96	No	No	0	7	9
249	R:R:C143	R:R:G140	1.96	No	No	0	4	1
250	R:R:G34	R:R:V74	1.84	No	No	0	9	5
251	R:R:A230	R:R:C287	1.81	No	No	0	5	7
252	R:R:G44	R:R:I299	1.76	No	No	0	7	6
253	R:R:G195	R:R:M194	1.75	No	No	0	3	5
254	R:R:G198	R:R:M197	1.75	No	Yes	0	4	7
255	R:R:G34	R:R:L33	1.71	No	No	0	9	5
256	R:R:A262	R:R:S265	1.71	No	No	0	1	3
257	R:R:A25	R:R:V26	1.7	No	No	0	4	5
258	R:R:A122	R:R:V129	1.7	No	No	0	8	6
259	R:R:C282	R:R:T30	1.69	No	No	0	7	7
260	R:R:D213	R:R:G210	1.68	No	No	0	3	5
261	R:R:E17	R:R:G14	1.64	No	No	0	3	3
262	R:R:G161	R:R:H160	1.59	No	Yes	0	4	5
263	R:R:C10	R:R:D9	1.56	Yes	No	0	8	6
264	R:R:I266	R:R:S265	1.55	No	No	0	5	3
265	R:R:I28	R:R:V32	1.54	No	No	0	4	5
266	R:R:K180	R:R:S178	1.53	No	No	0	3	4
267	R:R:K263	R:R:V258	1.52	No	No	0	3	2
268	R:R:C260	R:R:E259	1.52	No	No	0	7	5
269	R:R:L83	R:R:S88	1.5	No	No	0	5	8
270	R:R:L283	R:R:S238	1.5	No	No	0	7	7
271	R:R:L83	R:R:V82	1.49	No	No	0	5	4
272	R:R:L18	R:R:T21	1.47	No	No	0	4	3
273	R:R:L148	R:R:T151	1.47	No	No	0	4	3
274	R:R:D175	R:R:S173	1.47	No	No	0	2	4
275	R:R:F183	R:R:P184	1.44	No	No	0	4	4
276	R:R:F188	R:R:P184	1.44	No	No	0	4	4
277	R:R:F269	R:R:P241	1.44	No	No	0	5	9
278	R:R:I64	R:R:L49	1.43	No	No	0	5	5
279	R:R:Q85	R:R:V86	1.43	No	No	0	4	4
280	R:R:I257	R:R:L251	1.43	No	No	0	2	4
281	R:R:P126	R:R:Y125	1.39	No	No	0	8	6
282	R:R:L35	R:R:L36	1.38	Yes	No	0	5	4
283	R:R:H214	R:R:T215	1.37	No	No	0	4	3
284	R:R:F90	R:R:S88	1.32	No	No	0	6	8
285	R:R:R203	R:R:S202	1.32	Yes	No	0	4	3
286	R:R:H170	R:R:M167	1.31	No	No	0	5	3
287	R:R:D217	R:R:Q220	1.31	No	No	0	5	5
288	R:R:H131	R:R:L132	1.29	No	No	0	4	4
289	R:R:N171	R:R:R253	1.21	No	Yes	0	4	4
290	R:R:D174	R:R:R253	1.19	No	Yes	0	2	4
291	R:R:L128	R:R:Y125	1.17	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C10	4.9075	4	0	8
2	R:R:M19	7.304	5	3	5
3	R:R:F31	6.34	4	0	7
4	R:R:L35	3.6775	4	0	5
5	R:R:F45	5.644	5	2	7
6	R:R:Y62	7.08857	7	2	8
7	R:R:M63	5.3525	4	2	8
8	R:R:N65	8.4525	4	4	9
9	R:R:L66	6.14	4	2	9
10	R:R:D70	7.1425	4	0	9
11	R:R:Y101	8.43167	6	1	5
12	R:R:Y106	8.15	4	1	8
13	R:R:I112	6.035	4	2	8
14	R:R:Y157	8.25667	6	1	4
15	R:R:H160	8.08	5	1	5
16	R:R:F169	8.668	5	1	4
17	R:R:F190	7.335	4	0	9
18	R:R:M197	5.24	4	0	7
19	R:R:R203	6.245	4	0	4
20	R:R:Q249	5.4875	4	1	5
21	R:R:R253	4.685	4	1	4
22	R:R:N278	8.155	4	1	6
23	R:R:D284	6.886	5	2	9
24	R:R:Y288	6.97	5	2	9
25	R:R:Y289	4.65333	6	2	7
26	L:L:?1	8.31167	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F12	11.045	13.77	Yes	No	1	0	5
2	L:L:?1	R:R:H170	25.7772	8.08	Yes	No	0	0	5
3	R:R:H170	R:R:Q271	23.3302	4.95	No	No	0	5	5
4	R:R:M19	R:R:Q271	19.5206	20.39	Yes	No	3	5	5
5	R:R:F268	R:R:M19	14.3763	4.98	No	Yes	0	2	5
6	R:R:F268	R:R:L18	11.6011	6.09	No	No	0	2	4
7	R:R:L18	R:R:T21	10.1941	1.47	No	No	0	4	3
8	L:L:?1	R:R:F102	69.4066	12.24	Yes	No	1	0	5
9	R:R:F102	R:R:Y101	81.1301	6.19	No	Yes	1	5	5
10	R:R:N278	R:R:Y101	80.5684	11.63	Yes	Yes	1	6	5
11	R:R:L77	R:R:Y101	11.907	4.69	No	Yes	1	8	5
12	R:R:F31	R:R:L77	16.4785	3.65	Yes	No	0	7	8
13	R:R:F31	R:R:L35	12.541	6.09	Yes	Yes	0	7	5
14	R:R:L73	R:R:N278	86.5135	4.12	No	Yes	0	6	6
15	R:R:C281	R:R:L73	87.8928	4.76	No	No	0	8	6
16	R:R:C281	R:R:D70	87.9206	10.89	No	Yes	0	8	9
17	R:R:D284	R:R:D70	100	5.32	Yes	Yes	0	9	9
18	R:R:D284	R:R:L66	52.8947	6.79	Yes	Yes	2	9	9
19	R:R:L66	R:R:Y289	58.5563	4.69	Yes	Yes	2	9	7
20	R:R:D70	R:R:N38	14.0092	9.42	Yes	No	0	9	9
21	R:R:L35	R:R:L75	12.5855	2.77	Yes	No	0	5	4
22	R:R:L71	R:R:L75	12.5744	2.77	No	No	0	7	4
23	R:R:F45	R:R:Y289	32.8013	4.13	Yes	Yes	2	7	7
24	R:R:F45	R:R:F48	14.8268	4.29	Yes	No	0	7	6
25	R:R:M63	R:R:Y289	17.2627	4.79	Yes	Yes	2	8	7
26	R:R:F48	R:R:N298	11.907	7.25	No	No	0	6	5
27	R:R:N298	R:R:T47	10.6112	7.31	No	No	0	5	3
28	R:R:F45	R:R:I292	16.2282	3.77	Yes	No	0	7	7
29	R:R:E294	R:R:I292	14.8379	4.1	No	No	0	7	7
30	R:R:E294	R:R:Y56	13.3808	14.59	No	No	0	7	4
31	R:R:D55	R:R:Y56	11.9237	5.75	No	No	0	6	4
32	R:R:D55	R:R:P54	10.4499	4.83	No	No	0	6	6
33	R:R:M63	R:R:Y62	17.9189	4.79	Yes	Yes	2	8	8
34	R:R:I115	R:R:Y62	15.3329	6.04	No	Yes	2	8	8
35	R:R:I115	R:R:R119	17.2126	6.26	No	No	0	8	9
36	R:R:R119	R:R:Y288	18.1191	6.17	No	Yes	0	9	9
37	R:R:D284	R:R:Y288	19.5762	4.6	Yes	Yes	2	9	9
38	R:R:I138	R:R:Y62	13.175	4.84	No	Yes	0	8	8
39	R:R:I138	R:R:I61	10.5611	4.42	No	No	0	8	6
40	R:R:L66	R:R:T111	10.4666	7.37	Yes	No	0	9	8
41	R:R:D284	R:R:I112	32.4175	5.6	Yes	Yes	2	9	8
42	R:R:F169	R:R:Y101	22.9576	6.19	Yes	Yes	1	4	5
43	R:R:C168	R:R:F169	13.5198	4.19	No	Yes	0	9	4
44	R:R:C168	R:R:L83	12.0627	4.76	No	No	0	9	5
45	L:L:?1	R:R:Y157	11.4621	8.84	Yes	Yes	1	0	4
46	R:R:H160	R:R:Y157	12.5466	7.62	Yes	Yes	1	5	4
47	R:R:C99	R:R:Y157	13.6422	6.72	No	Yes	0	5	4
48	R:R:C99	R:R:W150	13.0972	3.92	No	No	0	5	3
49	R:R:V103	R:R:W150	12.7468	4.9	No	No	0	5	3
50	R:R:V103	R:R:V149	12.6522	4.81	No	No	0	5	7
51	L:L:?1	R:R:Y106	28.5301	11.79	Yes	Yes	1	0	8
52	R:R:H243	R:R:Y106	26.1776	5.44	No	Yes	0	8	8
53	R:R:F110	R:R:V149	12.5744	2.62	No	No	0	5	7
54	R:R:F110	R:R:V109	12.6244	2.62	No	No	0	5	8
55	R:R:F239	R:R:V109	14.0593	5.24	No	No	0	9	8
56	R:R:I112	R:R:M197	47.7004	4.37	Yes	Yes	0	8	7
57	R:R:M197	R:R:S116	26.2221	6.13	Yes	No	0	7	9
58	R:R:C200	R:R:S116	24.7595	5.16	No	No	0	7	9
59	R:R:C200	R:R:F120	20.3048	6.98	No	No	0	7	8
60	R:R:F120	R:R:R124	18.7976	5.34	No	No	0	8	6
61	R:R:I207	R:R:R124	12.6522	3.76	No	No	0	6	6
62	L:L:?1	R:R:Q249	20.0156	4.18	Yes	Yes	1	0	5
63	R:R:Q249	R:R:V252	10.1107	4.3	Yes	No	0	5	3
64	R:R:E186	R:R:H243	10.0384	11.08	No	No	0	5	8
65	R:R:F190	R:R:H243	15.4886	15.84	Yes	No	0	9	8
66	R:R:G198	R:R:M197	28.975	1.75	No	Yes	0	4	7
67	R:R:G198	R:R:L232	27.5346	3.42	No	No	0	4	8
68	R:R:C201	R:R:L232	26.0831	9.52	No	No	0	8	8
69	R:R:C201	R:R:I228	24.6204	3.27	No	No	0	8	7
70	R:R:I205	R:R:I228	23.1355	5.89	No	No	0	4	7
71	R:R:I205	R:R:I225	21.6451	4.42	No	No	0	4	5
72	R:R:I225	R:R:L209	20.2992	2.85	No	No	0	5	3
73	R:R:L209	R:R:W218	18.7976	3.42	No	No	0	3	4
74	R:R:R211	R:R:W218	14.3596	2	No	No	0	5	4
75	R:R:Q221	R:R:R211	12.808	4.67	No	No	0	6	5
76	R:R:D284	R:R:N280	14.4986	12.12	Yes	No	0	9	9
77	R:R:L270	R:R:Q249	10.4722	7.99	No	Yes	0	5	5
78	R:R:L71	R:R:N38	12.6522	4.12	No	No	0	7	9
79	R:R:F102	R:R:Y157	11.2674	11.35	No	Yes	1	5	4
80	R:R:F239	R:R:N280	10.0273	8.46	No	No	0	9	9
81	R:R:I112	R:R:L66	13.2473	5.71	Yes	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C10	R:R:F12	5.59	0	Yes	No	8	5	2	1
R:R:F12	R:R:S267	3.96	1	No	No	5	4	1	1
L:L:?1	R:R:F12	13.77	1	Yes	No	0	5	0	1
L:L:?1	R:R:N16	6.04	1	Yes	No	0	5	0	1
R:R:C99	R:R:Y157	6.72	0	No	Yes	5	4	2	1
R:R:F102	R:R:Y101	6.19	1	No	Yes	5	5	1	2
R:R:F102	R:R:Y157	11.35	1	No	Yes	5	4	1	1
L:L:?1	R:R:F102	12.24	1	Yes	No	0	5	0	1
R:R:M105	R:R:Y106	5.99	0	No	Yes	8	8	2	1
R:R:L185	R:R:Y106	9.38	1	No	Yes	5	8	1	1
R:R:H243	R:R:Y106	5.44	0	No	Yes	8	8	2	1
L:L:?1	R:R:Y106	11.79	1	Yes	Yes	0	8	0	1
R:R:S153	R:R:Y157	10.17	0	No	Yes	6	4	2	1
R:R:I156	R:R:Y157	4.84	0	No	Yes	4	4	2	1
R:R:H160	R:R:Y157	7.62	1	Yes	Yes	5	4	2	1
L:L:?1	R:R:Y157	8.84	1	Yes	Yes	0	4	0	1
R:R:H170	R:R:Q271	4.95	0	No	No	5	5	1	2
L:L:?1	R:R:H170	8.08	1	Yes	No	0	5	0	1
R:R:Q249	R:R:W177	5.48	1	Yes	No	5	3	1	1
R:R:R253	R:R:W177	11	1	Yes	No	4	3	1	1
L:L:?1	R:R:W177	10.73	1	Yes	No	0	3	0	1
L:L:?1	R:R:L185	9.57	1	Yes	No	0	5	0	1
R:R:F246	R:R:L270	6.09	0	No	No	6	5	2	2
R:R:F246	R:R:M274	6.22	0	No	No	6	6	2	1
R:R:Q249	R:R:V252	4.3	1	Yes	No	5	3	1	2
R:R:L270	R:R:Q249	7.99	0	No	Yes	5	5	2	1
L:L:?1	R:R:Q249	4.18	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R253	5.34	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S267	4.72	1	Yes	No	0	4	0	1
L:L:?1	R:R:M274	4.44	1	Yes	No	0	6	0	1
R:R:H170	R:R:M167	1.31	0	No	No	5	3	1	2
R:R:N171	R:R:R253	1.21	0	No	Yes	4	4	2	1
R:R:D174	R:R:R253	1.19	0	No	Yes	2	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9GE3_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	276
Number of Links	291
Number of Hubs	26
Number of Links mediated by Hubs	107
Number of Communities	4
Number of Nodes involved in Communities	35
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	82
Number Of Links MetaPath	81
Number of Shortest Paths	37855
Length Of Smallest Path	3
Average Path Length	13.2384
Length of Longest Path	36
Minimum Path Strength	1.28
Average Path Strength	6.33626
Maximum Path Strength	17.525
Minimum Path Correlation	0.7
Average Path Correlation	0.928299
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	53.3805
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1547
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • positive regulation of cell communication • small GTPase-mediated signal transduction • positive regulation of signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • Rho protein signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of Rho protein signal transduction • positive regulation of Rho protein signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of small GTPase mediated signal transduction • positive regulation of signaling • myeloid leukocyte differentiation • regulation of leukocyte differentiation • multicellular organismal process • cellular developmental process • regulation of developmental process • negative regulation of biological process • cell development • regulation of cell differentiation • regulation of cell development • regulation of osteoclast differentiation • multicellular organism development • cell differentiation • osteoclast differentiation • anatomical structure development • negative regulation of cellular process • regulation of immune system process • regulation of multicellular organismal process • negative regulation of cell differentiation • negative regulation of hemopoiesis • developmental process • regulation of multicellular organismal development • negative regulation of leukocyte differentiation • hemopoiesis • regulation of myeloid cell differentiation • negative regulation of developmental process • regulation of myeloid leukocyte differentiation • negative regulation of myeloid cell differentiation • negative regulation of osteoclast differentiation • negative regulation of myeloid leukocyte differentiation • negative regulation of cell development • myeloid cell differentiation • negative regulation of immune system process • immune system process • regulation of hemopoiesis • negative regulation of multicellular organismal process • leukocyte differentiation • positive regulation of ERK1 and ERK2 cascade • positive regulation of MAPK cascade • regulation of MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal-level homeostasis • homeostatic process • tissue remodeling • bone remodeling • anatomical structure homeostasis • tissue homeostasis • bone resorption • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • system development • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • signaling receptor binding • G protein-coupled receptor binding • D5 dopamine receptor binding • dopamine receptor binding • GTPase regulator activity • enzyme regulator activity • guanyl-nucleotide exchange factor activity • nucleoside-triphosphatase regulator activity • molecular function regulator activity • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • circulatory system process • regulation of blood pressure • regulation of biological quality • blood circulation • regulation of cell motility • regulation of fibroblast migration • fibroblast migration • regulation of locomotion • ameboidal-type cell migration • regulation of cell migration • cell migration • cell motility • locomotion • embryo development ending in birth or egg hatching • chordate embryonic development • embryo development • in utero embryonic development • regulation of cell shape • cell morphogenesis • regulation of cell morphogenesis • anatomical structure morphogenesis • regulation of anatomical structure morphogenesis • regulation of body fluid levels • wound healing • cell activation • hemostasis • blood coagulation • response to stress • coagulation • response to wounding • platelet activation • branching morphogenesis of an epithelial tube • angiogenesis • tube morphogenesis • epithelial tube morphogenesis • blood vessel development • epithelium development • blood vessel morphogenesis • tube development • morphogenesis of an epithelium • tissue development • vasculature development • circulatory system development • branching involved in blood vessel morphogenesis • tissue morphogenesis • morphogenesis of a branching structure • anatomical structure formation involved in morphogenesis • morphogenesis of a branching epithelium • regulation of cellular component organization • cellular component organization • cellular component biogenesis • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • Rho-activating G protein-coupled receptor signaling pathway • anchoring junction • focal adhesion • cell-substrate junction • pigment granule • intracellular vesicle • melanosome • cytoplasmic vesicle • brush border membrane • cluster of actin-based cell projections • brush border • apical part of cell • plasma membrane region • apical plasma membrane • cell projection membrane • postsynapse • nucleus
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	_L_
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds


Code	NAG
PDB Residues	H:H:?1
Environment Details	Open EMBL-EBI Page
Code	NAG
Name	N-Acetylglucosamine
Synonyms	N-Acetylchitosamine
Identifier
Formula	C8 H15 N O6
Molecular Weight	221.208
SMILES
PubChem	24139
Formal Charge	0
Total Atoms	30
Total Chiral Atoms	5
Total Bonds	30
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T6
Sequence	>9GE3_nogp_Chain_R D C L F D G V N E L M K T L Q F A V H I P T F V L G L L L N L L A I H G F S T F L K N R W P D Y A A T S I Y M I N L A V F D L L L V L S L P F K M V L S Q V Q S P F P S L C T L V E C L Y F V S M Y G S V F T I C F I S M D R F L A I R Y P L L V S H L R S P R K I F G I C C T I W V L V W T G S I P I Y S F H G Y M C F H N M S D D T W S A K V F F P L E V F G F L L P M G I M G F C C S R S I H I L L G R R D H T Q D W V Q Q K A C I Y S I A A S L A V F V V S F L P V H L G F F L Q F L V R N S F I V E C R A K Q S I S F F L Q L S M C F S N V N C C L D V F C Y Y F V I K E F R M N I R A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZX4	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(NtGi1-G13)/β1/γ2	3.03	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX4 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-		3.03	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-	chim(NtGi1-G13)/β1/γ2	2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	8ZX5 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	AM251	-		2.85	2024-11-13	doi.org/10.1038/s41422-024-01044-w
	9IYA	A	Lipid	GPR55	GPR55	Homo sapiens	ONO-9710531	-	-	3.04	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IY8	A	Lipid	GPR55	GPR55	Homo sapiens	-	-	chim(NtGi1-G13)/β1/γ2	3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9IY8 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	-	-		3.01	2025-01-01	doi.org/10.1038/s41422-024-01046-8
	9GE2	A	Lipid	GPR55	GPR55	Homo sapiens	ML184	-	chim(NtGi1-G13)/β1/γ2	2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE2 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	ML184	-		2.51	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE3	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-	chim(NtGi1-G13)/β1/γ2	2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y
	9GE3 (No Gprot)	A	Lipid	GPR55	GPR55	Homo sapiens	Lysophosphatidylinositol	-		2.87	2025-03-05	doi.org/10.1038/s41467-025-57204-y

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