psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T135	R:R:Y292	23.72	No	No	0	4	1
2	R:R:R293	R:R:Y136	6.17	No	No	0	4	4
3	R:R:R295	R:R:Y136	11.32	No	No	0	4	4
4	R:R:V137	R:R:V294	3.21	No	Yes	0	2	3
5	R:R:Y139	R:R:Y140	15.89	Yes	No	0	4	5
6	R:R:I210	R:R:Y139	14.51	Yes	Yes	0	6	4
7	R:R:L296	R:R:Y139	4.69	No	Yes	0	3	4
8	R:R:H142	R:R:L141	14.14	No	No	0	5	4
9	R:R:H142	R:R:N208	5.1	No	No	0	5	5
10	R:R:P144	R:R:Q143	3.16	No	No	0	3	6
11	R:R:Q143	R:R:Q145	6.4	No	No	0	6	3
12	R:R:Q143	R:R:V146	8.6	No	No	0	6	6
13	R:R:F150	R:R:Y154	10.32	No	Yes	0	5	7
14	R:R:F150	R:R:N208	15.71	No	No	0	5	5
15	R:R:I151	R:R:L205	2.85	No	No	0	6	6
16	R:R:L205	R:R:Y154	11.72	No	Yes	0	6	7
17	R:R:W422	R:R:Y154	5.79	Yes	Yes	0	6	7
18	R:R:F425	R:R:Y154	4.13	Yes	Yes	0	7	7
19	R:R:I157	R:R:M201	5.83	Yes	No	0	7	7
20	R:R:I157	R:R:W422	10.57	Yes	Yes	0	7	6
21	R:R:G426	R:R:I157	3.53	No	Yes	0	6	7
22	R:R:F158	R:R:M162	8.71	No	No	0	6	6
23	R:R:F158	R:R:M201	3.73	No	No	8	6	7
24	R:R:F158	R:R:P202	4.33	No	No	8	6	8
25	R:R:F159	R:R:L160	3.65	No	Yes	0	4	6
26	R:R:L160	R:R:M163	4.24	Yes	No	0	6	5
27	R:R:L160	R:R:S429	3	Yes	No	0	6	7
28	R:R:C161	R:R:N165	4.72	No	Yes	0	8	9
29	R:R:L194	R:R:M162	2.83	No	No	0	8	6
30	R:R:G164	R:R:M163	5.24	No	No	0	8	5
31	R:R:G164	R:R:P432	4.06	No	No	0	8	9
32	R:R:D193	R:R:N165	8.08	Yes	Yes	0	9	9
33	R:R:L194	R:R:N165	5.49	No	Yes	0	8	9
34	R:R:N165	R:R:P432	3.26	Yes	No	0	9	9
35	R:R:F446	R:R:V167	6.55	No	No	0	8	6
36	R:R:F170	R:R:R174	8.55	No	No	0	4	6
37	R:R:I171	R:R:M178	2.92	No	Yes	0	8	8
38	R:R:F442	R:R:I171	3.77	No	No	0	9	8
39	R:R:G445	R:R:I171	3.53	No	No	0	6	8
40	R:R:M173	R:R:V172	3.04	No	No	0	4	8
41	R:R:N183	R:R:V172	8.87	Yes	No	0	9	8
42	R:R:L187	R:R:V172	5.96	No	No	0	6	8
43	R:R:M178	R:R:N175	11.22	Yes	No	0	8	7
44	R:R:M178	R:R:N183	4.21	Yes	Yes	0	8	9
45	R:R:M178	R:R:N441	9.82	Yes	No	0	8	7
46	R:R:N183	R:R:T180	2.92	Yes	No	0	9	8
47	R:R:D244	R:R:V181	4.38	Yes	Yes	0	9	7
48	R:R:A262	R:R:V181	5.09	No	Yes	0	8	7
49	R:R:I241	R:R:T182	3.04	No	No	0	9	8
50	R:R:D244	R:R:T182	4.34	Yes	No	4	9	8
51	R:R:R245	R:R:T182	7.76	Yes	No	4	9	8
52	R:R:I186	R:R:N183	2.83	No	Yes	0	8	9
53	R:R:F263	R:R:L184	4.87	No	No	0	4	5
54	R:R:I266	R:R:L184	4.28	No	No	0	8	5
55	R:R:F185	R:R:T237	6.49	Yes	Yes	0	8	8
56	R:R:A240	R:R:F185	5.55	No	Yes	0	7	8
57	R:R:F185	R:R:I241	5.02	Yes	No	0	8	9
58	R:R:F185	R:R:I265	3.77	Yes	Yes	0	8	6
59	R:R:F185	R:R:I266	5.02	Yes	No	0	8	8
60	R:R:I186	R:R:Y435	18.13	No	Yes	0	8	9
61	R:R:N188	R:R:T237	8.77	No	Yes	0	9	8
62	R:R:I266	R:R:N188	7.08	No	No	0	8	9
63	R:R:N188	R:R:W270	9.04	No	No	0	9	9
64	R:R:L189	R:R:S234	3	No	No	0	9	9
65	R:R:L189	R:R:T237	7.37	No	Yes	0	9	8
66	R:R:D193	R:R:S192	2.94	Yes	No	0	9	9
67	R:R:S192	R:R:S230	6.52	No	No	0	9	7
68	R:R:S192	R:R:S234	4.89	No	No	0	9	9
69	R:R:D193	R:R:S428	10.31	Yes	No	0	9	9
70	R:R:D193	R:R:N431	4.04	Yes	Yes	0	9	9
71	R:R:S230	R:R:V196	4.85	No	No	0	7	8
72	R:R:S428	R:R:V196	4.85	No	No	0	9	8
73	R:R:F199	R:R:I198	3.77	No	No	0	6	5
74	R:R:F199	R:R:V226	10.49	No	No	0	6	5
75	R:R:C200	R:R:V226	3.42	No	No	0	7	5
76	R:R:C200	R:R:Q227	7.63	No	No	0	7	7
77	R:R:C200	R:R:F425	2.79	No	Yes	0	7	7
78	R:R:M201	R:R:P202	3.35	No	No	8	7	8
79	R:R:F215	R:R:I203	5.02	No	No	3	7	6
80	R:R:I203	R:R:M219	5.83	No	No	3	6	6
81	R:R:I203	R:R:S223	4.64	No	No	0	6	5
82	R:R:H421	R:R:T204	4.11	No	No	7	6	6
83	R:R:F425	R:R:T204	7.78	Yes	No	7	7	6
84	R:R:D207	R:R:W213	15.63	No	Yes	0	5	7
85	R:R:N208	R:R:P418	3.26	No	No	0	5	5
86	R:R:I210	R:R:P214	8.47	Yes	No	0	6	3
87	R:R:F215	R:R:W213	3.01	No	Yes	3	7	7
88	R:R:C220	R:R:W213	15.67	No	Yes	3	9	7
89	R:R:C308	R:R:W213	13.06	No	Yes	3	9	7
90	R:R:F215	R:R:M219	12.44	No	No	3	7	6
91	R:R:N217	R:R:T218	5.85	Yes	No	0	3	2
92	R:R:N217	R:R:V286	2.96	Yes	No	0	3	5
93	R:R:C220	R:R:C308	7.28	No	No	3	9	9
94	R:R:G224	R:R:S223	3.71	No	No	0	4	5
95	R:R:G224	R:R:Q227	6.58	No	No	0	4	7
96	R:R:I229	R:R:L225	7.14	Yes	No	0	7	6
97	R:R:A281	R:R:L225	6.3	No	No	0	5	6
98	R:R:G228	R:R:M277	3.49	No	Yes	0	6	8
99	R:R:I229	R:R:I274	4.42	Yes	No	0	7	4
100	R:R:V231	R:R:W389	4.9	No	Yes	0	7	8
101	R:R:A233	R:R:W270	7.78	No	No	0	8	9
102	R:R:F385	R:R:S234	3.96	Yes	No	0	9	9
103	R:R:I329	R:R:V235	3.07	Yes	No	0	6	8
104	R:R:P333	R:R:V235	3.53	No	No	0	9	8
105	R:R:F236	R:R:I269	8.79	No	No	0	6	8
106	R:R:F236	R:R:I329	3.77	No	Yes	0	6	6
107	R:R:I269	R:R:T237	3.04	No	Yes	0	8	8
108	R:R:F385	R:R:L238	3.65	Yes	No	0	9	9
109	R:R:I337	R:R:V239	4.61	No	No	0	9	7
110	R:R:I241	R:R:L378	7.14	No	No	0	9	8
111	R:R:A242	R:R:Y341	5.34	No	Yes	0	8	9
112	R:R:M340	R:R:V243	3.04	No	No	0	7	7
113	R:R:D244	R:R:R245	4.76	Yes	Yes	4	9	9
114	R:R:C248	R:R:R245	5.57	No	Yes	4	8	9
115	R:R:K371	R:R:R245	3.71	No	Yes	4	7	9
116	R:R:I374	R:R:R245	6.26	No	Yes	0	8	9
117	R:R:F246	R:R:V250	11.8	Yes	No	9	8	7
118	R:R:F246	R:R:Y251	3.09	Yes	No	9	8	6
119	R:R:F246	R:R:M340	6.22	Yes	No	0	8	7
120	R:R:F246	R:R:I344	5.02	Yes	Yes	0	8	9
121	R:R:C248	R:R:K371	4.85	No	No	4	8	7
122	R:R:I344	R:R:V249	4.61	Yes	No	0	9	9
123	R:R:S347	R:R:V249	3.23	No	No	0	5	9
124	R:R:K371	R:R:V249	3.04	No	No	0	7	9
125	R:R:V250	R:R:Y251	10.09	No	No	9	7	6
126	R:R:S347	R:R:V250	8.08	No	No	0	5	7
127	R:R:F253	R:R:Y251	7.22	No	No	0	6	6
128	R:R:K254	R:R:P255	6.69	No	No	0	5	5
129	R:R:T258	R:R:T261	6.28	No	No	0	8	6
130	R:R:F263	R:R:M267	3.73	No	No	0	4	4
131	R:R:I265	R:R:I269	2.94	Yes	No	0	6	8
132	R:R:I276	R:R:M277	4.37	No	Yes	2	5	8
133	R:R:I276	R:R:L325	2.85	No	Yes	2	5	5
134	R:R:M277	R:R:Y321	3.59	Yes	Yes	2	8	8
135	R:R:L325	R:R:M277	2.83	Yes	Yes	2	5	8
136	R:R:M283	R:R:W312	15.12	No	Yes	0	5	5
137	R:R:Q287	R:R:W307	14.24	No	No	0	2	4
138	R:R:D311	R:R:Q287	11.75	No	No	0	4	2
139	R:R:E289	R:R:Y292	11.22	Yes	No	0	3	1
140	R:R:E289	R:R:V305	2.85	Yes	No	0	3	4
141	R:R:E289	R:R:W307	3.27	Yes	No	0	3	4
142	R:R:K290	R:R:R293	6.19	No	No	0	3	4
143	R:R:R293	R:R:T302	3.88	No	No	0	4	3
144	R:R:V294	R:R:V305	4.81	Yes	No	0	3	4
145	R:R:R295	R:R:T302	5.17	No	No	0	4	3
146	R:R:R309	R:R:W307	9	No	No	0	4	4
147	R:R:E310	R:R:W312	6.54	No	Yes	2	5	5
148	R:R:E310	R:R:R318	5.82	No	Yes	2	5	4
149	R:R:P313	R:R:W312	4.05	No	Yes	0	8	5
150	R:R:R318	R:R:W312	14.99	Yes	Yes	2	4	5
151	R:R:W312	R:R:Y321	7.72	Yes	Yes	2	5	8
152	R:R:M317	R:R:P313	6.71	No	No	0	4	8
153	R:R:M317	R:R:N314	4.21	No	No	0	4	4
154	R:R:R318	R:R:T322	14.23	Yes	No	0	4	6
155	R:R:D400	R:R:R318	3.57	No	Yes	0	5	4
156	R:R:D400	R:R:K319	13.83	No	No	0	5	4
157	R:R:I320	R:R:T323	3.04	No	No	0	5	5
158	R:R:L325	R:R:Y321	8.21	Yes	Yes	2	5	8
159	R:R:I329	R:R:L325	2.85	Yes	Yes	0	6	5
160	R:R:F326	R:R:Y330	8.25	No	Yes	1	6	8
161	R:R:F326	R:R:L331	3.65	No	No	0	6	5
162	R:R:F326	R:R:W393	11.02	No	No	1	6	7
163	R:R:I329	R:R:N328	5.66	Yes	No	0	6	4
164	R:R:I386	R:R:Y330	6.04	No	Yes	0	6	8
165	R:R:L390	R:R:Y330	7.03	No	Yes	0	7	8
166	R:R:W393	R:R:Y330	11.58	No	Yes	1	7	8
167	R:R:I386	R:R:L334	7.14	No	No	0	6	7
168	R:R:I337	R:R:Y341	4.84	No	Yes	0	9	9
169	R:R:L378	R:R:Y341	4.69	No	Yes	0	8	9
170	R:R:L379	R:R:Y341	8.21	No	Yes	0	5	9
171	R:R:I346	R:R:R343	11.27	No	No	0	3	6
172	R:R:I344	R:R:I375	4.42	Yes	No	0	9	7
173	R:R:I374	R:R:L378	2.85	No	No	0	8	8
174	R:R:F438	R:R:K376	7.44	No	No	0	7	7
175	R:R:M377	R:R:Y435	3.59	No	Yes	0	8	9
176	R:R:F438	R:R:M377	9.95	No	No	0	7	8
177	R:R:M377	R:R:N439	5.61	No	No	0	8	8
178	R:R:I380	R:R:L384	2.85	No	No	1	6	7
179	R:R:I380	R:R:I434	4.42	No	Yes	1	6	9
180	R:R:N431	R:R:V381	5.91	Yes	No	1	9	8
181	R:R:I434	R:R:V381	3.07	Yes	No	1	9	8
182	R:R:V381	R:R:Y435	5.05	No	Yes	1	8	9
183	R:R:I434	R:R:L384	4.28	Yes	No	1	9	7
184	R:R:F385	R:R:W389	15.03	Yes	Yes	1	9	8
185	R:R:F385	R:R:N427	8.46	Yes	Yes	1	9	9
186	R:R:N427	R:R:S388	7.45	Yes	No	0	9	9
187	R:R:L392	R:R:W389	3.42	Yes	Yes	1	6	8
188	R:R:A424	R:R:W389	7.78	No	Yes	1	7	8
189	R:R:N427	R:R:W389	3.39	Yes	Yes	1	9	8
190	R:R:L390	R:R:P391	3.28	No	No	0	7	9
191	R:R:A420	R:R:L392	3.15	No	Yes	0	7	6
192	R:R:A424	R:R:L392	3.15	No	Yes	1	7	6
193	R:R:I412	R:R:L395	5.71	No	No	10	4	6
194	R:R:I416	R:R:L395	8.56	No	No	10	5	6
195	R:R:D400	R:R:S399	2.94	No	No	0	5	4
196	R:R:E408	R:R:L404	13.25	No	No	0	3	5
197	R:R:P406	R:R:S405	5.34	No	No	0	2	3
198	R:R:E408	R:R:S405	10.06	No	No	0	3	3
199	R:R:I411	R:R:N407	5.66	No	No	0	2	1
200	R:R:I414	R:R:Q410	5.49	No	No	0	4	1
201	R:R:I412	R:R:I416	2.94	No	No	10	4	5
202	R:R:N413	R:R:Y417	4.65	No	No	0	5	5
203	R:R:I414	R:R:Y415	6.04	No	No	0	4	3
204	R:R:F419	R:R:W422	4.01	No	Yes	6	5	6
205	R:R:F419	R:R:L423	4.87	No	No	6	5	8
206	R:R:F425	R:R:H421	11.31	Yes	No	7	7	6
207	R:R:L423	R:R:W422	3.42	No	Yes	6	8	6
208	R:R:N427	R:R:N431	4.09	Yes	Yes	1	9	9
209	R:R:N431	R:R:V430	2.96	Yes	No	0	9	6
210	R:R:I434	R:R:V430	3.07	Yes	No	0	9	6
211	R:R:N431	R:R:Y435	3.49	Yes	Yes	1	9	9
212	R:R:F446	R:R:G436	3.01	No	No	0	8	7
213	R:R:F442	R:R:N439	9.67	No	No	0	9	8
214	R:R:E448	R:R:G445	3.27	No	No	0	5	6
215	R:R:P304	R:R:Y306	2.78	No	No	0	4	5
216	R:R:A449	R:R:F170	2.77	No	No	0	5	4
217	R:R:K254	R:R:Q247	2.71	No	No	0	5	4
218	R:R:P214	R:R:W213	2.7	No	Yes	0	3	7
219	R:R:E440	R:R:K373	2.7	No	No	0	5	7
220	R:R:E310	R:R:L284	2.65	No	No	0	5	5
221	R:R:H179	R:R:M173	2.63	No	No	0	8	4
222	R:R:H179	R:R:K176	2.62	No	No	0	8	6
223	R:R:D244	R:R:Q247	2.61	Yes	No	0	9	4
224	R:R:H177	R:R:N175	2.55	No	No	0	5	7
225	R:R:V286	R:R:Y306	2.52	No	No	0	5	5
226	R:R:F199	R:R:I222	2.51	No	No	0	6	6
227	R:R:S153	R:R:W422	2.47	No	Yes	0	5	6
228	R:R:F170	R:R:L452	2.44	No	No	0	4	3
229	R:R:F236	R:R:L272	2.44	No	No	0	6	4
230	R:R:K290	R:R:Y291	2.39	No	No	0	3	2
231	R:R:I229	R:R:W270	2.35	Yes	No	0	7	9
232	R:R:L392	R:R:Y417	2.34	Yes	No	0	6	5
233	R:R:M396	R:R:W393	2.33	No	No	0	6	7
234	R:R:E288	R:R:Y306	2.24	No	No	0	3	5
235	R:R:E289	R:R:Y291	2.24	Yes	No	0	3	2
236	R:R:W389	R:R:Y330	1.93	Yes	Yes	1	8	8
237	R:R:A332	R:R:P333	1.87	No	No	0	6	9
238	R:R:G164	R:R:V167	1.84	No	No	0	8	6
239	R:R:G197	R:R:V196	1.84	No	No	0	7	8
240	R:R:G212	R:R:V305	1.84	No	No	0	5	4
241	R:R:A190	R:R:C169	1.81	No	No	0	9	7
242	R:R:A232	R:R:A273	1.79	No	No	0	6	8
243	R:R:P279	R:R:S278	1.78	No	No	0	9	5
244	R:R:P304	R:R:S303	1.78	No	No	0	4	3
245	R:R:P432	R:R:V168	1.77	No	No	0	9	9
246	R:R:G345	R:R:I344	1.76	No	Yes	0	6	9
247	R:R:C308	R:R:V286	1.71	No	No	0	9	5
248	R:R:A190	R:R:V168	1.7	No	No	0	9	9
249	R:R:A211	R:R:V294	1.7	No	Yes	0	4	3
250	R:R:G216	R:R:N217	1.7	No	Yes	0	8	3
251	R:R:C169	R:R:I191	1.64	No	No	0	7	7
252	R:R:A147	R:R:I209	1.62	No	No	0	4	5
253	R:R:A273	R:R:I229	1.62	No	Yes	0	8	7
254	R:R:A232	R:R:I276	1.62	No	No	0	6	5
255	R:R:A232	R:R:I329	1.62	No	Yes	0	6	6
256	R:R:S278	R:R:V282	1.62	No	No	0	5	5
257	R:R:S303	R:R:V294	1.62	No	Yes	0	3	3
258	R:R:A382	R:R:I337	1.62	No	No	0	8	9
259	R:R:A281	R:R:K221	1.61	No	No	0	5	7
260	R:R:A402	R:R:L398	1.58	No	No	0	3	5
261	R:R:A402	R:R:L404	1.58	No	No	0	3	5
262	R:R:I274	R:R:S278	1.55	No	No	0	4	5
263	R:R:I259	R:R:V181	1.54	No	Yes	0	4	7
264	R:R:I265	R:R:T261	1.52	Yes	No	0	6	6
265	R:R:M397	R:R:T322	1.51	No	No	0	6	6
266	R:R:M397	R:R:T323	1.51	No	No	0	6	5
267	R:R:K260	R:R:T258	1.5	No	No	0	5	8
268	R:R:L409	R:R:S399	1.5	No	No	0	4	4
269	R:R:G445	R:R:R444	1.5	No	No	0	6	5
270	R:R:L257	R:R:V181	1.49	No	Yes	0	6	7
271	R:R:L195	R:R:V226	1.49	No	No	0	7	5
272	R:R:L334	R:R:V338	1.49	No	No	0	7	5
273	R:R:N407	R:R:S405	1.49	No	No	0	1	3
274	R:R:I209	R:R:I210	1.47	No	Yes	5	5	6
275	R:R:I265	R:R:I268	1.47	Yes	No	0	6	4
276	R:R:L395	R:R:T394	1.47	No	No	0	6	7
277	R:R:I411	R:R:I416	1.47	No	No	0	2	5
278	R:R:F253	R:R:P252	1.44	No	No	0	6	8
279	R:R:I157	R:R:L156	1.43	Yes	No	0	7	4
280	R:R:I433	R:R:L160	1.43	No	Yes	0	7	6
281	R:R:I209	R:R:L206	1.43	No	No	5	5	4
282	R:R:I210	R:R:L206	1.43	Yes	No	5	6	4
283	R:R:I386	R:R:L387	1.43	No	No	0	6	6
284	R:R:K373	R:R:N439	1.4	No	No	0	7	8
285	R:R:A449	R:R:F450	1.39	No	No	0	5	5
286	R:R:H142	R:R:V146	1.38	No	No	0	5	6
287	R:R:E316	R:R:I320	1.37	No	No	0	1	5
288	R:R:I375	R:R:Q372	1.37	No	No	0	7	5
289	R:R:N407	R:R:Q410	1.32	No	No	0	1	1
290	R:R:F450	R:R:V167	1.31	No	No	0	5	6
291	R:R:H285	R:R:N217	1.28	No	Yes	0	5	3
292	R:R:S280	R:R:Y321	1.27	No	Yes	0	6	8
293	R:R:K319	R:R:Y401	1.19	No	No	0	4	5
294	R:R:Q447	R:R:R443	1.17	No	No	0	5	9
295	R:R:N138	R:R:Y139	1.16	No	Yes	0	3	4
296	R:R:F246	R:R:R343	1.07	Yes	No	0	8	6
297	R:R:F437	R:R:F438	1.07	No	No	0	6	7
298	R:R:F437	R:R:R443	1.07	No	No	0	6	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y139	9.0625	4	0	4
2	R:R:Y154	7.99	4	0	7
3	R:R:I157	5.34	4	0	7
4	R:R:L160	3.08	4	0	6
5	R:R:N165	5.3875	4	0	9
6	R:R:M178	7.0425	4	0	8
7	R:R:V181	3.125	4	0	7
8	R:R:N183	4.7075	4	0	9
9	R:R:F185	5.17	5	0	8
10	R:R:D193	6.3425	4	0	9
11	R:R:I210	6.47	4	5	6
12	R:R:W213	10.014	5	3	7
13	R:R:N217	2.9475	4	0	3
14	R:R:I229	3.8825	4	0	7
15	R:R:T237	6.4175	4	0	8
16	R:R:D244	4.0225	4	4	9
17	R:R:R245	5.612	5	4	9
18	R:R:F246	5.44	5	9	8
19	R:R:I265	2.425	4	0	6
20	R:R:M277	3.57	4	2	8
21	R:R:E289	4.895	4	0	3
22	R:R:V294	2.835	4	0	3
23	R:R:W312	9.684	5	2	5
24	R:R:R318	9.6525	4	2	4
25	R:R:Y321	5.1975	4	2	8
26	R:R:L325	4.185	4	2	5
27	R:R:I329	3.394	5	0	6
28	R:R:Y330	6.966	5	1	8
29	R:R:Y341	5.77	4	0	9
30	R:R:I344	3.9525	4	0	9
31	R:R:F385	7.775	4	1	9
32	R:R:W389	6.075	6	1	8
33	R:R:L392	3.015	4	1	6
34	R:R:W422	5.252	5	6	6
35	R:R:F425	6.5025	4	7	7
36	R:R:N427	5.8475	4	1	9
37	R:R:N431	4.098	5	1	9
38	R:R:I434	3.71	4	1	9
39	R:R:Y435	7.565	4	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E289	R:R:V305	16.5995	2.85	Yes	No	0	3	4
2	R:R:V294	R:R:V305	18.8289	4.81	Yes	No	0	3	4
3	R:R:S303	R:R:V294	22.1058	1.62	No	Yes	0	3	3
4	R:R:P304	R:R:S303	23.1802	1.78	No	No	0	4	3
5	R:R:P304	R:R:Y306	24.1606	2.78	No	No	0	4	5
6	R:R:V286	R:R:Y306	26.2691	2.52	No	No	0	5	5
7	R:R:C308	R:R:V286	31.3726	1.71	No	No	0	9	5
8	R:R:C308	R:R:W213	32.2365	13.06	No	Yes	3	9	7
9	R:R:P214	R:R:W213	10.7977	2.7	No	Yes	0	3	7
10	R:R:F150	R:R:Y154	10.7709	10.32	No	Yes	0	5	7
11	R:R:F425	R:R:Y154	55.6854	4.13	Yes	Yes	0	7	7
12	R:R:C200	R:R:F425	53.4023	2.79	No	Yes	0	7	7
13	R:R:C200	R:R:Q227	48.5943	7.63	No	No	0	7	7
14	R:R:G224	R:R:Q227	47.7617	6.58	No	No	0	4	7
15	R:R:G224	R:R:S223	46.92	3.71	No	No	0	4	5
16	R:R:I203	R:R:S223	46.0695	4.64	No	No	0	6	5
17	R:R:F215	R:R:I203	44.1445	5.02	No	No	3	7	6
18	R:R:F215	R:R:W213	43.5312	3.01	No	Yes	3	7	7
19	R:R:W422	R:R:Y154	63.9628	5.79	Yes	Yes	0	6	7
20	R:R:I157	R:R:W422	66.4518	10.57	Yes	Yes	0	7	6
21	R:R:I157	R:R:M201	68.2245	5.83	Yes	No	0	7	7
22	R:R:F158	R:R:M201	68.4573	3.73	No	No	8	6	7
23	R:R:F158	R:R:M162	69.9167	8.71	No	No	0	6	6
24	R:R:G164	R:R:P432	16.3981	4.06	No	No	0	8	9
25	R:R:N165	R:R:P432	21.9044	3.26	Yes	No	0	9	9
26	R:R:L194	R:R:N165	71.0001	5.49	No	Yes	0	8	9
27	R:R:L194	R:R:M162	70.4629	2.83	No	No	0	8	6
28	R:R:D193	R:R:N165	80.0877	8.08	Yes	Yes	0	9	9
29	R:R:M178	R:R:N183	13.1077	4.21	Yes	Yes	0	8	9
30	R:R:I186	R:R:N183	23.9413	2.83	No	Yes	0	8	9
31	R:R:I186	R:R:Y435	25.4812	18.13	No	Yes	0	8	9
32	R:R:N431	R:R:Y435	47.7885	3.49	Yes	Yes	1	9	9
33	R:R:D193	R:R:N431	48.6033	4.04	Yes	Yes	0	9	9
34	R:R:M377	R:R:N439	13.0227	5.61	No	No	0	8	8
35	R:R:M377	R:R:Y435	22.352	3.59	No	Yes	0	8	9
36	R:R:D244	R:R:T182	11.5901	4.34	Yes	No	4	9	8
37	R:R:I241	R:R:T182	42.5956	3.04	No	No	0	9	8
38	R:R:F185	R:R:I241	54.5707	5.02	Yes	No	0	8	9
39	R:R:F185	R:R:T237	56.3166	6.49	Yes	Yes	0	8	8
40	R:R:L189	R:R:T237	99.5344	7.37	No	Yes	0	9	8
41	R:R:L189	R:R:S234	100	3	No	No	0	9	9
42	R:R:S192	R:R:S234	71.9491	4.89	No	No	0	9	9
43	R:R:D193	R:R:S192	70.9329	2.94	Yes	No	0	9	9
44	R:R:R245	R:R:T182	29.7923	7.76	Yes	No	4	9	8
45	R:R:N188	R:R:T237	18.5513	8.77	No	Yes	0	9	8
46	R:R:F185	R:R:I265	12.8436	3.77	Yes	Yes	0	8	6
47	R:R:I265	R:R:I269	12.4586	2.94	Yes	No	0	6	8
48	R:R:I269	R:R:T237	44.4982	3.04	No	Yes	0	8	8
49	R:R:N188	R:R:W270	15.543	9.04	No	No	0	9	9
50	R:R:I229	R:R:W270	13.4211	2.35	Yes	No	0	7	9
51	R:R:I329	R:R:L325	35.03	2.85	Yes	Yes	0	6	5
52	R:R:F236	R:R:I329	43.2268	3.77	No	Yes	0	6	6
53	R:R:F236	R:R:I269	45.689	8.79	No	No	0	6	8
54	R:R:N427	R:R:N431	33.4363	4.09	Yes	Yes	1	9	9
55	R:R:N427	R:R:W389	11.7916	3.39	Yes	Yes	1	9	8
56	R:R:F385	R:R:S234	31.0995	3.96	Yes	No	0	9	9
57	R:R:F385	R:R:N427	21.488	8.46	Yes	Yes	1	9	9
58	R:R:I241	R:R:L378	11.3797	7.14	No	No	0	9	8
59	R:R:F246	R:R:I344	12.2258	5.02	Yes	Yes	0	8	9
60	R:R:I344	R:R:V249	18.1171	4.61	Yes	No	0	9	9
61	R:R:K371	R:R:V249	27.0705	3.04	No	No	0	7	9
62	R:R:K371	R:R:R245	28.4045	3.71	No	Yes	4	7	9
63	R:R:L325	R:R:Y321	30.6384	8.21	Yes	Yes	2	5	8
64	R:R:W312	R:R:Y321	29.0044	7.72	Yes	Yes	2	5	8
65	R:R:R318	R:R:W312	17.8754	14.99	Yes	Yes	2	4	5
66	R:R:W389	R:R:Y330	13.1928	1.93	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9JG0

PDB Summary
PDB	9JG0
Class	A
SubFamily	Peptide
Type	Neuropeptide FF
SubType	NPFF2
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.91
Date	2025-04-09
D.O.I.	doi.org/10.1038/s44319-025-00428-2

Net Summary
I_min	2.79
Number of Linked Nodes	271
Number of Links	298
Number of Hubs	39
Number of Links mediated by Hubs	142
Number of Communities	10
Number of Nodes involved in Communities	50
Number of Links involved in Communities	58

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	43978
Length Of Smallest Path	3
Average Path Length	16.7876
Length of Longest Path	46
Minimum Path Strength	1.07
Average Path Strength	5.26149
Maximum Path Strength	17.47
Minimum Path Correlation	0.7
Average Path Correlation	0.93084
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.5641
Average % Of Corr. Nodes	48.7856
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.3024
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway
Gene Ontology	Biological Process	• electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway • detection of stimulus • response to abiotic stimulus • detection of abiotic stimulus • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • cellular anatomical structure • periplasmic space • intracellular organelle • intracellular anatomical structure • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • actin cytoskeleton • cell periphery • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Cytochromes
SCOP2	Family Identifier	• Cytochromes
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5X5
Sequence	>9JG0_Chain_R I T Y V N Y Y L H Q P Q V A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N K H M H T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G W P F G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y P F K P K L T I K T A F V I I M I I W V L A I T I M S P S A V M L H V Q E E K Y Y R V R L N K T S P V Y W C R E D W P N Q E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A D L S P N E L Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F R R G F Q E A F Q L Q L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JFY	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-SF	-	Gi1/β1/γ2	3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JFY (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-SF	-		3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JG0	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	-	-	-	2.91	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-VF	-		3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JG0.zip

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