psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F1	L:L:F3	5.36	Yes	Yes	2	0	0
2	L:L:F1	R:R:T135	3.89	Yes	No	2	0	4
3	L:L:F1	R:R:V137	3.93	Yes	No	0	0	2
4	L:L:F1	R:R:Y292	38.17	Yes	Yes	2	0	1
5	L:L:L2	R:R:L141	6.92	No	Yes	0	0	4
6	L:L:L2	R:R:W307	4.56	No	Yes	0	0	4
7	L:L:F3	L:L:Q4	8.2	Yes	Yes	2	0	0
8	L:L:F3	R:R:Y292	4.13	Yes	Yes	2	0	1
9	L:L:F3	R:R:W307	8.02	Yes	Yes	2	0	4
10	L:L:F3	R:R:Q410	3.51	Yes	No	0	0	1
11	L:L:F3	R:R:N413	4.83	Yes	No	0	0	5
12	L:L:Q4	L:L:Q6	3.84	Yes	No	0	0	0
13	L:L:Q4	R:R:W307	8.76	Yes	Yes	2	0	4
14	L:L:Q4	R:R:R309	8.18	Yes	No	2	0	4
15	L:L:P5	R:R:N413	6.52	No	No	0	0	5
16	L:L:P5	R:R:Y417	19.47	No	Yes	0	0	5
17	L:L:Q6	R:R:D207	5.22	No	No	0	0	5
18	L:L:F8	L:L:R7	4.28	Yes	Yes	0	0	0
19	L:L:R7	R:R:R318	13.86	Yes	Yes	0	0	4
20	L:L:R7	R:R:T322	3.88	Yes	No	0	0	6
21	L:L:R7	R:R:M396	7.44	Yes	No	0	0	6
22	L:L:?9	L:L:F8	9.04	No	Yes	0	0	0
23	L:L:F8	R:R:V231	10.49	Yes	No	0	0	7
24	L:L:F8	R:R:M277	3.73	Yes	Yes	0	0	8
25	L:L:F8	R:R:W393	4.01	Yes	Yes	0	0	7
26	L:L:?9	R:R:C200	3.93	No	No	1	0	7
27	L:L:?9	R:R:Q227	16.47	No	Yes	1	0	7
28	R:R:T135	R:R:Y291	12.48	No	No	2	4	2
29	R:R:T135	R:R:Y292	4.99	No	Yes	2	4	1
30	R:R:R293	R:R:Y136	31.9	Yes	No	6	4	4
31	R:R:R295	R:R:Y136	4.12	Yes	No	6	4	4
32	R:R:T302	R:R:Y136	6.24	No	No	6	3	4
33	R:R:N138	R:R:R295	7.23	No	Yes	0	3	4
34	R:R:Y139	R:R:Y140	17.87	No	No	0	4	5
35	R:R:I210	R:R:Y139	10.88	No	No	0	6	4
36	R:R:H142	R:R:L141	3.86	No	Yes	0	5	4
37	R:R:A211	R:R:L141	4.73	No	Yes	0	4	4
38	R:R:H142	R:R:V146	5.54	No	No	0	5	6
39	R:R:Q143	R:R:Q145	10.24	No	No	0	6	3
40	R:R:F150	R:R:P418	5.78	No	No	0	5	5
41	R:R:I151	R:R:L205	4.28	No	No	0	6	6
42	R:R:I151	R:R:I209	4.42	No	No	0	6	5
43	R:R:S153	R:R:Y154	5.09	No	Yes	1	5	7
44	R:R:S153	R:R:W422	8.65	No	Yes	1	5	6
45	R:R:T204	R:R:Y154	3.75	Yes	Yes	1	6	7
46	R:R:L205	R:R:Y154	8.21	No	Yes	0	6	7
47	R:R:W422	R:R:Y154	5.79	Yes	Yes	1	6	7
48	R:R:F425	R:R:Y154	6.19	Yes	Yes	1	7	7
49	R:R:L156	R:R:L160	5.54	No	No	0	4	6
50	R:R:I157	R:R:M201	4.37	Yes	Yes	0	7	7
51	R:R:I157	R:R:W422	11.74	Yes	Yes	0	7	6
52	R:R:G426	R:R:I157	3.53	No	Yes	0	6	7
53	R:R:F158	R:R:M162	12.44	Yes	No	0	6	6
54	R:R:F158	R:R:I198	5.02	Yes	No	0	6	5
55	R:R:F158	R:R:M201	7.46	Yes	Yes	0	6	7
56	R:R:F158	R:R:P202	5.78	Yes	No	0	6	8
57	R:R:F159	R:R:L160	6.09	No	No	0	4	6
58	R:R:F159	R:R:M163	3.73	No	No	0	4	5
59	R:R:C161	R:R:N165	4.72	No	Yes	0	8	9
60	R:R:D193	R:R:N165	6.73	Yes	Yes	4	9	9
61	R:R:L194	R:R:N165	10.98	No	Yes	0	8	9
62	R:R:N165	R:R:P432	9.77	Yes	No	4	9	9
63	R:R:F170	R:R:R174	7.48	No	No	0	4	6
64	R:R:I171	R:R:R174	5.01	No	No	0	8	6
65	R:R:F442	R:R:I171	5.02	Yes	No	0	9	8
66	R:R:L187	R:R:V172	7.45	No	No	0	6	8
67	R:R:N175	R:R:R174	7.23	Yes	No	0	7	6
68	R:R:H177	R:R:N175	17.86	No	Yes	0	5	7
69	R:R:M178	R:R:N175	14.02	No	Yes	0	8	7
70	R:R:N175	R:R:R444	8.44	Yes	No	0	7	5
71	R:R:H179	R:R:K176	11.79	No	No	0	8	6
72	R:R:M178	R:R:N183	5.61	No	No	0	8	9
73	R:R:T180	R:R:T182	4.71	No	No	0	8	8
74	R:R:N183	R:R:T180	5.85	No	No	0	9	8
75	R:R:F185	R:R:V181	3.93	Yes	Yes	0	8	7
76	R:R:A262	R:R:V181	5.09	No	Yes	0	8	7
77	R:R:F442	R:R:N183	6.04	Yes	No	0	9	9
78	R:R:A240	R:R:F185	4.16	No	Yes	0	7	8
79	R:R:F185	R:R:I241	5.02	Yes	No	0	8	9
80	R:R:F185	R:R:I265	5.02	Yes	No	0	8	6
81	R:R:F185	R:R:I266	5.02	Yes	No	0	8	8
82	R:R:N188	R:R:T237	10.24	No	No	0	9	8
83	R:R:I266	R:R:N188	14.16	No	No	0	8	9
84	R:R:N188	R:R:W270	6.78	No	No	0	9	9
85	R:R:D193	R:R:L189	8.14	Yes	Yes	4	9	9
86	R:R:L189	R:R:T237	4.42	Yes	No	0	9	8
87	R:R:L189	R:R:L238	4.15	Yes	No	4	9	9
88	R:R:L189	R:R:Y435	4.69	Yes	Yes	4	9	9
89	R:R:D193	R:R:S428	8.83	Yes	No	0	9	9
90	R:R:D193	R:R:N431	8.08	Yes	No	0	9	9
91	R:R:D193	R:R:P432	9.66	Yes	No	4	9	9
92	R:R:L195	R:R:S230	6.01	No	No	0	7	7
93	R:R:G197	R:R:V196	3.68	No	No	0	7	8
94	R:R:S428	R:R:V196	8.08	No	No	0	9	8
95	R:R:G197	R:R:M201	5.24	No	Yes	0	7	7
96	R:R:F199	R:R:I198	7.54	No	No	0	6	5
97	R:R:F199	R:R:V226	11.8	No	No	0	6	5
98	R:R:C200	R:R:Q227	12.21	No	Yes	1	7	7
99	R:R:C200	R:R:F425	5.59	No	Yes	1	7	7
100	R:R:F425	R:R:M201	7.46	Yes	Yes	0	7	7
101	R:R:I203	R:R:S223	7.74	No	No	1	6	5
102	R:R:I203	R:R:Q227	4.12	No	Yes	1	6	7
103	R:R:H421	R:R:T204	5.48	No	Yes	1	6	6
104	R:R:F425	R:R:T204	6.49	Yes	Yes	1	7	6
105	R:R:F215	R:R:L206	4.87	Yes	No	0	7	4
106	R:R:N208	R:R:P418	4.89	No	No	0	5	5
107	R:R:I210	R:R:P214	10.16	No	No	0	6	3
108	R:R:G212	R:R:W307	5.63	No	Yes	0	5	4
109	R:R:P214	R:R:W213	4.05	No	Yes	7	3	7
110	R:R:F215	R:R:W213	17.04	Yes	Yes	7	7	7
111	R:R:C220	R:R:W213	9.14	No	Yes	7	9	7
112	R:R:V286	R:R:W213	3.68	No	Yes	0	5	7
113	R:R:C308	R:R:W213	18.28	No	Yes	7	9	7
114	R:R:F215	R:R:P214	17.34	Yes	No	7	7	3
115	R:R:F215	R:R:M219	8.71	Yes	No	0	7	6
116	R:R:H285	R:R:N217	5.1	No	No	0	5	3
117	R:R:N217	R:R:V286	10.35	No	No	0	3	5
118	R:R:C220	R:R:C308	7.28	No	No	7	9	9
119	R:R:G224	R:R:S223	3.71	No	No	0	4	5
120	R:R:Q227	R:R:S223	7.22	Yes	No	1	7	5
121	R:R:I229	R:R:L225	7.14	No	No	0	7	6
122	R:R:I229	R:R:I274	5.89	No	No	0	7	4
123	R:R:V231	R:R:W389	6.13	No	Yes	0	7	8
124	R:R:A233	R:R:W270	6.48	No	No	0	8	9
125	R:R:P333	R:R:V235	3.53	No	No	0	9	8
126	R:R:F385	R:R:V235	3.93	No	No	0	9	8
127	R:R:F236	R:R:I269	5.02	No	No	0	6	8
128	R:R:L238	R:R:N431	8.24	No	No	0	9	9
129	R:R:L238	R:R:Y435	5.86	No	Yes	4	9	9
130	R:R:I241	R:R:R245	5.01	No	Yes	4	9	9
131	R:R:I241	R:R:Y435	8.46	No	Yes	4	9	9
132	R:R:A242	R:R:Y341	4	No	Yes	0	8	9
133	R:R:M340	R:R:V243	6.09	No	No	0	7	7
134	R:R:R245	R:R:Y341	7.2	Yes	Yes	0	9	9
135	R:R:M377	R:R:R245	3.72	No	Yes	0	8	9
136	R:R:R245	R:R:Y435	6.17	Yes	Yes	4	9	9
137	R:R:F246	R:R:V250	14.42	Yes	Yes	9	8	7
138	R:R:F246	R:R:M340	12.44	Yes	No	0	8	7
139	R:R:F246	R:R:R343	6.41	Yes	No	9	8	6
140	R:R:L257	R:R:Q247	5.32	No	No	0	6	4
141	R:R:I344	R:R:V249	9.22	Yes	No	0	9	9
142	R:R:V250	R:R:Y251	8.83	Yes	No	0	7	6
143	R:R:R343	R:R:V250	3.92	No	Yes	9	6	7
144	R:R:S347	R:R:V250	4.85	No	Yes	0	5	7
145	R:R:K254	R:R:Y251	9.55	No	No	0	5	6
146	R:R:F253	R:R:P252	10.11	No	No	0	6	8
147	R:R:K260	R:R:T258	6.01	No	No	0	5	8
148	R:R:T258	R:R:T261	7.85	No	No	0	8	6
149	R:R:I276	R:R:M277	4.37	No	Yes	0	5	8
150	R:R:I276	R:R:N328	5.66	No	No	0	5	4
151	R:R:M277	R:R:Y321	4.79	Yes	Yes	0	8	8
152	R:R:S280	R:R:Y321	5.09	No	Yes	0	6	8
153	R:R:E310	R:R:M283	10.83	No	No	3	5	5
154	R:R:M283	R:R:W312	6.98	No	Yes	3	5	5
155	R:R:H285	R:R:Q287	4.95	No	No	0	5	2
156	R:R:Q287	R:R:R309	10.51	No	No	2	2	4
157	R:R:D311	R:R:Q287	10.44	No	No	2	4	2
158	R:R:E288	R:R:Y306	12.35	No	No	0	3	5
159	R:R:E289	R:R:Y292	5.61	No	Yes	0	3	1
160	R:R:Y291	R:R:Y292	5.96	No	Yes	2	2	1
161	R:R:V305	R:R:Y292	10.09	No	Yes	0	4	1
162	R:R:W307	R:R:Y292	9.65	Yes	Yes	2	4	1
163	R:R:R293	R:R:R295	10.66	Yes	Yes	6	4	4
164	R:R:N300	R:R:R293	7.23	No	Yes	6	3	4
165	R:R:R293	R:R:T302	21.99	Yes	No	6	4	3
166	R:R:S303	R:R:V294	6.46	No	No	0	3	3
167	R:R:N300	R:R:R295	7.23	No	Yes	6	3	4
168	R:R:K301	R:R:L296	11.28	No	No	0	1	3
169	R:R:P304	R:R:S303	3.56	No	No	0	4	3
170	R:R:P304	R:R:Y306	4.17	No	No	0	4	5
171	R:R:D311	R:R:R309	5.96	No	No	2	4	4
172	R:R:E310	R:R:W312	21.81	No	Yes	3	5	5
173	R:R:E310	R:R:R318	5.82	No	Yes	3	5	4
174	R:R:P313	R:R:W312	5.4	No	Yes	3	8	5
175	R:R:M317	R:R:W312	16.29	Yes	Yes	3	4	5
176	R:R:R318	R:R:W312	11	Yes	Yes	3	4	5
177	R:R:M317	R:R:P313	8.39	Yes	No	3	4	8
178	R:R:E316	R:R:N314	5.26	No	No	0	1	4
179	R:R:M317	R:R:N314	8.41	Yes	No	0	4	4
180	R:R:D400	R:R:R318	5.96	Yes	Yes	3	5	4
181	R:R:D400	R:R:K319	6.91	Yes	No	3	5	4
182	R:R:K319	R:R:Y401	8.36	No	Yes	3	4	5
183	R:R:L325	R:R:Y321	10.55	No	Yes	0	5	8
184	R:R:D400	R:R:T322	10.12	Yes	No	0	5	6
185	R:R:T323	R:R:Y401	6.24	No	Yes	0	5	5
186	R:R:F326	R:R:Y330	8.25	Yes	No	5	6	8
187	R:R:F326	R:R:L331	7.31	Yes	No	0	6	5
188	R:R:F326	R:R:W393	15.03	Yes	Yes	5	6	7
189	R:R:F326	R:R:M397	11.2	Yes	No	0	6	6
190	R:R:I329	R:R:W393	10.57	No	Yes	0	6	7
191	R:R:L334	R:R:Y330	4.69	No	No	0	7	8
192	R:R:W393	R:R:Y330	8.68	Yes	No	5	7	8
193	R:R:F385	R:R:L334	6.09	No	No	0	9	7
194	R:R:I386	R:R:L334	5.71	No	No	0	6	7
195	R:R:I337	R:R:Y341	4.84	No	Yes	0	9	9
196	R:R:L378	R:R:Y341	16.41	No	Yes	0	8	9
197	R:R:V381	R:R:Y341	3.79	No	Yes	0	8	9
198	R:R:G345	R:R:I344	3.53	No	Yes	0	6	9
199	R:R:I344	R:R:L378	4.28	Yes	No	0	9	8
200	R:R:I346	R:R:R350	5.01	No	No	0	3	5
201	R:R:K371	R:R:L348	12.69	No	Yes	0	7	9
202	R:R:K371	R:R:S368	7.65	No	No	0	7	4
203	R:R:F438	R:R:M377	7.46	No	No	0	7	8
204	R:R:L379	R:R:L383	5.54	No	No	0	5	6
205	R:R:L384	R:R:S388	4.5	No	No	0	7	9
206	R:R:F385	R:R:W389	6.01	No	Yes	0	9	8
207	R:R:S388	R:R:W389	4.94	No	Yes	5	9	8
208	R:R:N427	R:R:S388	10.43	No	No	5	9	9
209	R:R:W389	R:R:W393	5.62	Yes	Yes	5	8	7
210	R:R:A424	R:R:W389	5.19	No	Yes	0	7	8
211	R:R:N427	R:R:W389	11.3	No	Yes	5	9	8
212	R:R:L423	R:R:P391	4.93	No	No	0	8	9
213	R:R:L392	R:R:Y417	4.69	No	Yes	0	6	5
214	R:R:I412	R:R:L395	8.56	No	No	0	4	6
215	R:R:L395	R:R:Y417	5.86	No	Yes	0	6	5
216	R:R:M396	R:R:Y417	3.59	No	Yes	0	6	5
217	R:R:M397	R:R:Y401	8.38	No	Yes	0	6	5
218	R:R:D400	R:R:Y401	11.49	Yes	Yes	3	5	5
219	R:R:E408	R:R:L404	9.28	No	No	0	3	5
220	R:R:L404	R:R:L409	4.15	No	No	0	5	4
221	R:R:P406	R:R:S405	3.56	No	No	0	2	3
222	R:R:E408	R:R:S405	12.94	No	No	0	3	3
223	R:R:I414	R:R:Q410	6.86	No	No	0	4	1
224	R:R:I414	R:R:Y415	7.25	No	No	0	4	3
225	R:R:H421	R:R:Y417	5.44	No	Yes	0	6	5
226	R:R:F419	R:R:L423	8.53	No	No	0	5	8
227	R:R:F425	R:R:H421	9.05	Yes	No	1	7	6
228	R:R:G426	R:R:S429	3.71	No	No	0	6	7
229	R:R:N427	R:R:N431	8.17	No	No	0	9	9
230	R:R:I434	R:R:Y435	6.04	No	Yes	0	9	9
231	R:R:F442	R:R:G436	4.52	Yes	No	0	9	7
232	R:R:F437	R:R:R443	5.34	No	No	0	6	9
233	R:R:N439	R:R:N441	13.62	No	No	8	8	7
234	R:R:F442	R:R:N439	10.87	Yes	No	8	9	8
235	R:R:F442	R:R:N441	4.83	Yes	No	8	9	7
236	R:R:G228	R:R:M277	3.49	No	Yes	0	6	8
237	R:R:A233	R:R:S192	3.42	No	No	0	8	9
238	R:R:L423	R:R:W422	3.42	No	Yes	0	8	6
239	R:R:A190	R:R:V168	3.39	No	No	0	9	9
240	R:R:K254	R:R:P255	3.35	No	No	0	5	5
241	R:R:L390	R:R:P391	3.28	No	No	0	7	9
242	R:R:C169	R:R:M173	3.24	No	No	0	7	4
243	R:R:S230	R:R:V196	3.23	No	No	0	7	8
244	R:R:V294	R:R:V305	3.21	No	No	0	3	4
245	R:R:F438	R:R:R443	3.21	No	No	0	7	9
246	R:R:A281	R:R:L225	3.15	No	No	0	5	6
247	R:R:A420	R:R:L392	3.15	No	No	0	7	6
248	R:R:I337	R:R:V239	3.07	No	No	0	9	7
249	R:R:I268	R:R:V264	3.07	No	No	0	4	3
250	R:R:I433	R:R:V430	3.07	No	No	0	7	6
251	R:R:I186	R:R:T182	3.04	No	No	0	8	8
252	R:R:I269	R:R:T237	3.04	No	No	0	8	8
253	R:R:I274	R:R:T275	3.04	No	No	0	4	4
254	R:R:M283	R:R:V282	3.04	No	No	0	5	5
255	R:R:L189	R:R:S234	3	Yes	No	0	9	9
256	R:R:L257	R:R:V181	2.98	No	Yes	0	6	7
257	R:R:L257	R:R:T261	2.95	No	No	0	6	6
258	R:R:L390	R:R:T394	2.95	No	No	0	7	7
259	R:R:I411	R:R:I414	2.94	No	No	0	2	4
260	R:R:I412	R:R:I416	2.94	No	No	0	4	5
261	R:R:A147	R:R:H142	2.93	No	No	0	4	5
262	R:R:N208	R:R:T204	2.92	No	Yes	0	5	6
263	R:R:I320	R:R:M317	2.92	No	Yes	0	5	4
264	R:R:I374	R:R:K373	2.91	No	No	0	8	7
265	R:R:I380	R:R:K376	2.91	No	No	0	6	7
266	R:R:D244	R:R:T182	2.89	No	No	0	9	8
267	R:R:Q143	R:R:V146	2.87	No	No	0	6	6
268	R:R:I157	R:R:L156	2.85	Yes	No	0	7	4
269	R:R:I191	R:R:L187	2.85	No	No	0	7	6
270	R:R:K221	R:R:L284	2.82	No	No	0	7	5
271	R:R:A232	R:R:F236	2.77	No	No	0	6	6
272	R:R:L409	R:R:N413	2.75	No	No	0	4	5
273	R:R:E289	R:R:K290	2.7	No	No	0	3	3
274	R:R:F246	R:R:I344	2.51	Yes	Yes	0	8	9
275	R:R:F263	R:R:I259	2.51	No	No	0	4	4
276	R:R:F263	R:R:L184	2.44	No	No	0	4	5
277	R:R:F236	R:R:L272	2.44	No	No	0	6	4
278	R:R:D244	R:R:F185	2.39	No	Yes	0	9	8
279	R:R:I229	R:R:W270	2.35	No	No	0	7	9
280	R:R:Q315	R:R:R318	2.34	No	Yes	0	2	4
281	R:R:A332	R:R:P333	1.87	No	No	0	6	9
282	R:R:G164	R:R:V167	1.84	No	No	0	8	6
283	R:R:G436	R:R:V168	1.84	No	No	0	7	9
284	R:R:A190	R:R:C169	1.81	No	No	0	9	7
285	R:R:A232	R:R:A273	1.79	No	No	0	6	8
286	R:R:A233	R:R:A273	1.79	No	No	0	8	8
287	R:R:P279	R:R:S278	1.78	No	No	0	9	5
288	R:R:G164	R:R:I433	1.76	No	No	0	8	7
289	R:R:G345	R:R:I375	1.76	No	No	0	6	7
290	R:R:G164	R:R:M163	1.75	No	No	0	8	5
291	R:R:G345	R:R:L348	1.71	No	Yes	0	6	9
292	R:R:C169	R:R:I191	1.64	No	No	0	7	7
293	R:R:C220	R:R:L284	1.59	No	No	0	9	5
294	R:R:T275	R:R:V271	1.59	No	No	0	4	5
295	R:R:P144	R:R:Q143	1.58	No	No	0	3	6
296	R:R:A327	R:R:L331	1.58	No	No	0	5	5
297	R:R:A402	R:R:L404	1.58	No	No	0	3	5
298	R:R:C248	R:R:D244	1.56	No	No	0	8	9
299	R:R:I259	R:R:V181	1.54	No	Yes	0	4	7
300	R:R:I222	R:R:V226	1.54	No	No	0	6	5
301	R:R:I339	R:R:V338	1.54	No	No	0	5	5
302	R:R:F215	R:R:G216	1.51	Yes	No	0	7	8
303	R:R:L296	R:R:S298	1.5	No	No	0	3	2
304	R:R:L409	R:R:S399	1.5	No	No	0	4	4
305	R:R:N407	R:R:S405	1.49	No	No	0	1	3
306	R:R:I265	R:R:I268	1.47	No	No	0	6	4
307	R:R:L398	R:R:T394	1.47	No	No	0	5	7
308	R:R:K370	R:R:K373	1.44	No	No	10	7	7
309	R:R:I374	R:R:L348	1.43	No	Yes	0	8	9
310	R:R:I386	R:R:L383	1.43	No	No	0	6	6
311	R:R:I386	R:R:L387	1.43	No	No	0	6	6
312	R:R:P252	R:R:Y251	1.39	No	No	0	8	6
313	R:R:L141	R:R:N138	1.37	Yes	No	0	4	3
314	R:R:E440	R:R:K370	1.35	No	No	10	5	7
315	R:R:E440	R:R:K373	1.35	No	No	10	5	7
316	R:R:A382	R:R:Y341	1.33	No	Yes	0	8	9
317	R:R:H179	R:R:L184	1.29	No	No	0	8	5
318	R:R:F150	R:R:I149	1.26	No	No	0	5	5
319	R:R:V324	R:R:Y321	1.26	No	Yes	0	5	8
320	R:R:I339	R:R:R343	1.25	No	No	0	5	6
321	R:R:K370	R:R:R369	1.24	No	No	0	7	5
322	R:R:F349	R:R:L348	1.22	No	Yes	0	4	9
323	R:R:Q372	R:R:R369	1.17	No	No	0	5	5
324	R:R:N297	R:R:Y139	1.16	No	No	0	2	4
325	R:R:F155	R:R:F159	1.07	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F1	12.8375	4	2	0
2	L:L:F3	5.675	6	2	0
3	L:L:Q4	7.245	4	2	0
4	L:L:R7	7.365	4	0	0
5	L:L:F8	6.31	5	0	0
6	R:R:L141	4.22	4	0	4
7	R:R:Y154	5.806	5	1	7
8	R:R:I157	5.6225	4	0	7
9	R:R:F158	7.675	4	0	6
10	R:R:N165	8.05	4	4	9
11	R:R:N175	11.8875	4	0	7
12	R:R:V181	3.385	4	0	7
13	R:R:F185	4.25667	6	0	8
14	R:R:L189	4.88	5	4	9
15	R:R:D193	8.288	5	4	9
16	R:R:M201	6.1325	4	0	7
17	R:R:T204	4.66	4	1	6
18	R:R:W213	10.438	5	7	7
19	R:R:F215	9.894	5	7	7
20	R:R:Q227	10.005	4	1	7
21	R:R:R245	5.525	4	4	9
22	R:R:F246	8.945	4	9	8
23	R:R:V250	8.005	4	9	7
24	R:R:M277	4.095	4	0	8
25	R:R:Y292	11.2286	7	2	1
26	R:R:R293	17.945	4	6	4
27	R:R:R295	7.31	4	6	4
28	R:R:W307	7.324	5	2	4
29	R:R:W312	12.296	5	3	5
30	R:R:M317	9.0025	4	3	4
31	R:R:R318	7.796	5	3	4
32	R:R:Y321	5.4225	4	0	8
33	R:R:F326	10.4475	4	5	6
34	R:R:Y341	6.26167	6	0	9
35	R:R:I344	4.885	4	0	9
36	R:R:L348	4.2625	4	0	9
37	R:R:W389	6.53167	6	5	8
38	R:R:W393	8.782	5	5	7
39	R:R:D400	8.62	4	3	5
40	R:R:Y401	8.6175	4	3	5
41	R:R:Y417	7.81	5	0	5
42	R:R:W422	7.4	4	1	6
43	R:R:F425	6.956	5	1	7
44	R:R:Y435	6.244	5	4	9
45	R:R:F442	6.256	5	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F3	R:R:W307	26.7577	8.02	Yes	Yes	2	0	4
2	L:L:L2	R:R:W307	25.9646	4.56	No	Yes	0	0	4
3	L:L:L2	R:R:L141	24.3957	6.92	No	Yes	0	0	4
4	L:L:F3	L:L:Q4	34.9057	8.2	Yes	Yes	2	0	0
5	L:L:F3	R:R:N413	87.6384	4.83	Yes	No	0	0	5
6	L:L:Q4	R:R:R309	32.6023	8.18	Yes	No	2	0	4
7	L:L:P5	R:R:N413	98.7931	6.52	No	No	0	0	5
8	L:L:P5	R:R:Y417	100	19.47	No	Yes	0	0	5
9	R:R:M396	R:R:Y417	67.1598	3.59	No	Yes	0	6	5
10	L:L:R7	R:R:M396	67.839	7.44	Yes	No	0	0	6
11	L:L:F8	L:L:R7	78.0214	4.28	Yes	Yes	0	0	0
12	L:L:R7	R:R:R318	25.075	13.86	Yes	Yes	0	0	4
13	L:L:?9	L:L:F8	15.3477	9.04	No	Yes	0	0	0
14	R:R:C200	R:R:F425	11.7444	5.59	No	Yes	1	7	7
15	R:R:F425	R:R:H421	43.5675	9.05	Yes	No	1	7	6
16	R:R:H421	R:R:Y417	49.2397	5.44	No	Yes	0	6	5
17	L:L:F8	R:R:V231	42.4158	10.49	Yes	No	0	0	7
18	L:L:F8	R:R:M277	12.3306	3.73	Yes	Yes	0	0	8
19	L:L:F8	R:R:W393	48.3811	4.01	Yes	Yes	0	0	7
20	R:R:L141	R:R:N138	11.6548	1.37	Yes	No	0	4	3
21	R:R:N138	R:R:R295	10.01	7.23	No	Yes	0	3	4
22	R:R:Q287	R:R:R309	29.5197	10.51	No	No	2	2	4
23	R:R:H285	R:R:Q287	27.9783	4.95	No	No	0	5	2
24	R:R:H285	R:R:N217	26.3681	5.1	No	No	0	5	3
25	R:R:N217	R:R:V286	24.7509	10.35	No	No	0	3	5
26	R:R:V286	R:R:W213	23.1268	3.68	No	Yes	0	5	7
27	R:R:H142	R:R:L141	10.01	3.86	No	Yes	0	5	4
28	R:R:F425	R:R:M201	48.3707	7.46	Yes	Yes	0	7	7
29	R:R:I157	R:R:M201	16.1167	4.37	Yes	Yes	0	7	7
30	R:R:I157	R:R:L156	10.0824	2.85	Yes	No	0	7	4
31	R:R:G197	R:R:M201	47.719	5.24	No	Yes	0	7	7
32	R:R:G197	R:R:V196	47.5053	3.68	No	No	0	7	8
33	R:R:S428	R:R:V196	47.1742	8.08	No	No	0	9	8
34	R:R:D193	R:R:S428	47.3949	8.83	Yes	No	0	9	9
35	R:R:V231	R:R:W389	42.3985	6.13	No	Yes	0	7	8
36	R:R:N427	R:R:W389	86.5246	11.3	No	Yes	5	9	8
37	R:R:N427	R:R:N431	87.2142	8.17	No	No	0	9	9
38	R:R:L238	R:R:N431	78.349	8.24	No	No	0	9	9
39	R:R:L238	R:R:Y435	71.3251	5.86	No	Yes	4	9	9
40	R:R:I241	R:R:Y435	56.836	8.46	No	Yes	4	9	9
41	R:R:F185	R:R:I241	63.022	5.02	Yes	No	0	8	9
42	R:R:D244	R:R:F185	40.1952	2.39	No	Yes	0	9	8
43	R:R:D244	R:R:T182	37.3918	2.89	No	No	0	9	8
44	R:R:T180	R:R:T182	34.4161	4.71	No	No	0	8	8
45	R:R:N183	R:R:T180	32.9161	5.85	No	No	0	9	8
46	R:R:W389	R:R:W393	47.4673	5.62	Yes	Yes	5	8	7
47	R:R:D193	R:R:L189	52.2085	8.14	Yes	Yes	4	9	9
48	R:R:L189	R:R:Y435	39.7021	4.69	Yes	Yes	4	9	9
49	R:R:F442	R:R:N183	22.0889	6.04	Yes	No	0	9	9
50	R:R:F442	R:R:G436	12.9892	4.52	Yes	No	0	9	7
51	R:R:G436	R:R:V168	11.3893	1.84	No	No	0	7	9
52	R:R:F185	R:R:V181	18.9304	3.93	Yes	Yes	0	8	7
53	R:R:L189	R:R:T237	22.0303	4.42	Yes	No	0	9	8
54	R:R:N188	R:R:T237	15.5167	10.24	No	No	0	9	8
55	R:R:N188	R:R:W270	15.5064	6.78	No	No	0	9	9
56	R:R:R245	R:R:Y435	52.0637	6.17	Yes	Yes	4	9	9
57	R:R:R245	R:R:Y341	52.5947	7.2	Yes	Yes	0	9	9
58	R:R:L378	R:R:Y341	44.1674	16.41	No	Yes	0	8	9
59	R:R:I344	R:R:L378	42.664	4.28	Yes	No	0	9	8
60	R:R:F246	R:R:I344	21.3337	2.51	Yes	Yes	0	8	9
61	R:R:F246	R:R:V250	11.5582	14.42	Yes	Yes	9	8	7
62	R:R:R318	R:R:W312	13.5409	11	Yes	Yes	3	4	5
63	R:R:V305	R:R:Y292	10.4445	10.09	No	Yes	0	4	1
64	R:R:G345	R:R:I344	19.389	3.53	No	Yes	0	6	9
65	R:R:G345	R:R:L348	16.1684	1.71	No	Yes	0	6	9
66	R:R:L409	R:R:N413	13.1789	2.75	No	No	0	4	5
67	L:L:F3	R:R:Y292	17.258	4.13	Yes	Yes	2	0	1

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:F1	R:R:T135	3.89	2	Yes	No	0	4	0	1
L:L:F1	R:R:V137	3.93	2	Yes	No	0	2	0	1
L:L:F1	R:R:Y292	38.17	2	Yes	Yes	0	1	0	1
L:L:L2	R:R:L141	6.92	0	No	Yes	0	4	0	1
L:L:L2	R:R:W307	4.56	0	No	Yes	0	4	0	1
L:L:F3	R:R:Y292	4.13	2	Yes	Yes	0	1	0	1
L:L:F3	R:R:W307	8.02	2	Yes	Yes	0	4	0	1
L:L:F3	R:R:Q410	3.51	2	Yes	No	0	1	0	1
L:L:F3	R:R:N413	4.83	2	Yes	No	0	5	0	1
L:L:Q4	R:R:W307	8.76	2	Yes	Yes	0	4	0	1
L:L:Q4	R:R:R309	8.18	2	Yes	No	0	4	0	1
L:L:P5	R:R:N413	6.52	0	No	No	0	5	0	1
L:L:P5	R:R:Y417	19.47	0	No	Yes	0	5	0	1
L:L:Q6	R:R:D207	5.22	0	No	No	0	5	0	1
L:L:R7	R:R:R318	13.86	0	Yes	Yes	0	4	0	1
L:L:R7	R:R:T322	3.88	0	Yes	No	0	6	0	1
L:L:R7	R:R:M396	7.44	0	Yes	No	0	6	0	1
L:L:F8	R:R:V231	10.49	0	Yes	No	0	7	0	1
L:L:F8	R:R:M277	3.73	0	Yes	Yes	0	8	0	1
L:L:F8	R:R:W393	4.01	0	Yes	Yes	0	7	0	1
L:L:?9	R:R:C200	3.93	1	No	No	0	7	0	1
L:L:?9	R:R:Q227	16.47	1	No	Yes	0	7	0	1
R:R:T135	R:R:Y291	12.48	2	No	No	4	2	1	2
R:R:T135	R:R:Y292	4.99	2	No	Yes	4	1	1	1
R:R:H142	R:R:L141	3.86	0	No	Yes	5	4	2	1
R:R:A211	R:R:L141	4.73	0	No	Yes	4	4	2	1
R:R:C200	R:R:Q227	12.21	1	No	Yes	7	7	1	1
R:R:C200	R:R:F425	5.59	1	No	Yes	7	7	1	2
R:R:I203	R:R:S223	7.74	1	No	No	6	5	2	2
R:R:I203	R:R:Q227	4.12	1	No	Yes	6	7	2	1
R:R:G212	R:R:W307	5.63	0	No	Yes	5	4	2	1
R:R:Q227	R:R:S223	7.22	1	Yes	No	7	5	1	2
R:R:V231	R:R:W389	6.13	0	No	Yes	7	8	1	2
R:R:I276	R:R:M277	4.37	0	No	Yes	5	8	2	1
R:R:M277	R:R:Y321	4.79	0	Yes	Yes	8	8	1	2
R:R:Q287	R:R:R309	10.51	2	No	No	2	4	2	1
R:R:D311	R:R:Q287	10.44	2	No	No	4	2	2	2
R:R:E289	R:R:Y292	5.61	0	No	Yes	3	1	2	1
R:R:Y291	R:R:Y292	5.96	2	No	Yes	2	1	2	1
R:R:V305	R:R:Y292	10.09	0	No	Yes	4	1	2	1
R:R:W307	R:R:Y292	9.65	2	Yes	Yes	4	1	1	1
R:R:D311	R:R:R309	5.96	2	No	No	4	4	2	1
R:R:E310	R:R:W312	21.81	3	No	Yes	5	5	2	2
R:R:E310	R:R:R318	5.82	3	No	Yes	5	4	2	1
R:R:R318	R:R:W312	11	3	Yes	Yes	4	5	1	2
R:R:D400	R:R:R318	5.96	3	Yes	Yes	5	4	2	1
R:R:D400	R:R:T322	10.12	3	Yes	No	5	6	2	1
R:R:F326	R:R:Y330	8.25	5	Yes	No	6	8	2	2
R:R:F326	R:R:W393	15.03	5	Yes	Yes	6	7	2	1
R:R:I329	R:R:W393	10.57	0	No	Yes	6	7	2	1
R:R:W393	R:R:Y330	8.68	5	Yes	No	7	8	1	2
R:R:W389	R:R:W393	5.62	5	Yes	Yes	8	7	2	1
R:R:L392	R:R:Y417	4.69	0	No	Yes	6	5	2	1
R:R:L395	R:R:Y417	5.86	0	No	Yes	6	5	2	1
R:R:M396	R:R:Y417	3.59	0	No	Yes	6	5	1	1
R:R:I414	R:R:Q410	6.86	0	No	No	4	1	2	1
R:R:H421	R:R:Y417	5.44	1	No	Yes	6	5	2	1
R:R:F425	R:R:H421	9.05	1	Yes	No	7	6	2	2
R:R:G228	R:R:M277	3.49	0	No	Yes	6	8	2	1
R:R:L409	R:R:N413	2.75	0	No	No	4	5	2	1
R:R:Q315	R:R:R318	2.34	0	No	Yes	2	4	2	1
R:R:L141	R:R:N138	1.37	0	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M1O_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.51
Number of Linked Nodes	291
Number of Links	325
Number of Hubs	45
Number of Links mediated by Hubs	169
Number of Communities	10
Number of Nodes involved in Communities	63
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	65057
Length Of Smallest Path	3
Average Path Length	15.8499
Length of Longest Path	38
Minimum Path Strength	1.205
Average Path Strength	6.75406
Maximum Path Strength	24.13
Minimum Path Correlation	0.7
Average Path Correlation	0.928811
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	46.3484
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.4031
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • dendrite • dendritic tree • neuron projection • non-motile cilium • 9+0 non-motile cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • peptide receptor activity • G protein-coupled peptide receptor activity • neuropeptide receptor activity • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • detection of stimulus • detection of abiotic stimulus • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • actin cytoskeleton
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5X5
Sequence	>9M1O_nogp_Chain_R T Y V N Y Y L H Q P Q V A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N K H M H T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G W P F G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y P F K P K L T I K T A F V I I M I I W V L A I T I M S P S A V M L H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A D L S P N E L Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JFY	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-	Gi1/β1/γ2	3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JFY (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-		3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JG0	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	-	-	-	2.91	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-	Gi1/β1/γ2	3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-		3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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