psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	R:R:E289	4.72	No	Yes	4	0	3
2	L:L:P2	R:R:R309	4.32	No	No	4	0	4
3	L:L:N3	R:R:D207	12.12	No	No	0	0	5
4	L:L:N3	R:R:W307	15.82	No	Yes	0	0	4
5	L:L:L4	R:R:N413	4.12	No	No	0	0	5
6	L:L:P5	R:R:N413	6.52	No	No	0	0	5
7	L:L:P5	R:R:Y417	12.52	No	Yes	0	0	5
8	L:L:Q6	R:R:D207	11.75	No	No	0	0	5
9	L:L:F8	L:L:R7	6.41	Yes	No	1	0	0
10	L:L:R7	R:R:M396	3.72	No	Yes	1	0	6
11	L:L:R7	R:R:Y417	6.17	No	Yes	1	0	5
12	L:L:F8	R:R:V231	6.55	Yes	No	0	0	7
13	L:L:F8	R:R:M277	7.46	Yes	No	0	0	8
14	L:L:F8	R:R:W393	4.01	Yes	Yes	1	0	7
15	L:L:F8	R:R:M396	3.73	Yes	Yes	1	0	6
16	L:L:?9	R:R:T204	3.65	Yes	Yes	1	0	6
17	L:L:?9	R:R:Q227	9.88	Yes	Yes	1	0	7
18	L:L:?9	R:R:H421	6.36	Yes	Yes	1	0	6
19	L:L:?9	R:R:F425	6.03	Yes	Yes	1	0	7
20	R:R:I134	R:R:Y136	15.71	No	Yes	2	3	4
21	R:R:I134	R:R:R293	18.79	No	Yes	2	3	4
22	R:R:T135	R:R:Y292	24.97	No	No	0	4	1
23	R:R:R293	R:R:Y136	17.49	Yes	Yes	2	4	4
24	R:R:R295	R:R:Y136	9.26	No	Yes	0	4	4
25	R:R:T302	R:R:Y136	4.99	No	Yes	2	3	4
26	R:R:V137	R:R:Y292	5.05	No	No	0	2	1
27	R:R:N138	R:R:N300	4.09	No	No	0	3	3
28	R:R:V294	R:R:Y139	12.62	No	Yes	0	3	4
29	R:R:L296	R:R:Y139	3.52	Yes	Yes	0	3	4
30	R:R:A147	R:R:Y140	4	No	No	0	4	5
31	R:R:I209	R:R:Y140	10.88	No	No	0	5	5
32	R:R:H142	R:R:V146	5.54	No	No	0	5	6
33	R:R:F150	R:R:H142	16.97	No	No	0	5	5
34	R:R:H142	R:R:Y415	4.36	No	No	0	5	3
35	R:R:Q143	R:R:V146	5.73	No	No	0	6	6
36	R:R:P144	R:R:Q145	4.74	No	No	0	3	3
37	R:R:F150	R:R:N208	7.25	No	Yes	1	5	5
38	R:R:F150	R:R:P418	7.22	No	No	1	5	5
39	R:R:S153	R:R:W422	6.18	No	No	0	5	6
40	R:R:T204	R:R:Y154	7.49	Yes	No	1	6	7
41	R:R:F425	R:R:Y154	7.22	Yes	No	1	7	7
42	R:R:F155	R:R:L156	4.87	No	No	0	4	4
43	R:R:I157	R:R:M201	7.29	No	Yes	0	7	7
44	R:R:I157	R:R:W422	7.05	No	No	0	7	6
45	R:R:F158	R:R:M162	6.22	No	No	0	6	6
46	R:R:F158	R:R:M201	4.98	No	Yes	0	6	7
47	R:R:F159	R:R:M163	8.71	No	No	0	4	5
48	R:R:C161	R:R:M201	4.86	No	Yes	0	8	7
49	R:R:C161	R:R:S429	6.89	No	No	0	8	7
50	R:R:I198	R:R:M162	4.37	No	No	0	5	6
51	R:R:G164	R:R:M163	5.24	No	No	0	8	5
52	R:R:D193	R:R:N165	6.73	Yes	No	0	9	9
53	R:R:L194	R:R:N165	4.12	No	No	0	8	9
54	R:R:N165	R:R:P432	11.4	No	No	0	9	9
55	R:R:F170	R:R:R174	5.34	No	No	0	4	6
56	R:R:F442	R:R:I171	6.28	Yes	No	0	9	8
57	R:R:L187	R:R:V172	7.45	No	No	0	6	8
58	R:R:N175	R:R:R174	13.26	No	No	0	7	6
59	R:R:H177	R:R:N175	7.65	No	No	5	5	7
60	R:R:M178	R:R:N175	7.01	No	No	5	8	7
61	R:R:H177	R:R:M178	6.57	No	No	5	5	8
62	R:R:H177	R:R:R444	6.77	No	No	0	5	5
63	R:R:F442	R:R:M178	3.73	Yes	No	0	9	8
64	R:R:N183	R:R:T180	7.31	No	No	0	9	8
65	R:R:L257	R:R:V181	4.47	No	No	0	6	7
66	R:R:I259	R:R:V181	6.14	No	No	0	4	7
67	R:R:D244	R:R:T182	5.78	No	No	0	9	8
68	R:R:I186	R:R:N183	4.25	No	No	0	8	9
69	R:R:F442	R:R:N183	6.04	Yes	No	0	9	9
70	R:R:F185	R:R:I241	5.02	Yes	No	0	8	9
71	R:R:D244	R:R:F185	3.58	No	Yes	0	9	8
72	R:R:A262	R:R:F185	4.16	No	Yes	0	8	8
73	R:R:F185	R:R:I265	5.02	Yes	No	0	8	6
74	R:R:N188	R:R:T237	7.31	Yes	No	0	9	8
75	R:R:I266	R:R:N188	8.5	No	Yes	0	8	9
76	R:R:I269	R:R:N188	5.66	No	Yes	0	8	9
77	R:R:N188	R:R:W270	7.91	Yes	No	0	9	9
78	R:R:L189	R:R:S192	4.5	Yes	No	1	9	9
79	R:R:D193	R:R:L189	8.14	Yes	Yes	1	9	9
80	R:R:L189	R:R:T237	5.9	Yes	No	0	9	8
81	R:R:L189	R:R:N431	12.36	Yes	Yes	1	9	9
82	R:R:D193	R:R:S192	5.89	Yes	No	1	9	9
83	R:R:D193	R:R:S428	4.42	Yes	No	0	9	9
84	R:R:D193	R:R:N431	10.77	Yes	Yes	1	9	9
85	R:R:L195	R:R:S230	6.01	No	No	0	7	7
86	R:R:S230	R:R:V196	4.85	No	No	0	7	8
87	R:R:S428	R:R:V196	9.7	No	No	0	9	8
88	R:R:G197	R:R:M201	5.24	No	Yes	0	7	7
89	R:R:F199	R:R:I198	11.3	No	No	0	6	5
90	R:R:F199	R:R:V226	9.18	No	No	0	6	5
91	R:R:C200	R:R:Q227	6.1	No	Yes	0	7	7
92	R:R:C200	R:R:F425	8.38	No	Yes	0	7	7
93	R:R:M201	R:R:P202	5.03	Yes	No	0	7	8
94	R:R:F425	R:R:M201	12.44	Yes	Yes	0	7	7
95	R:R:I203	R:R:W213	8.22	No	Yes	1	6	7
96	R:R:I203	R:R:S223	9.29	No	No	1	6	5
97	R:R:I203	R:R:Q227	16.47	No	Yes	1	6	7
98	R:R:N208	R:R:T204	4.39	Yes	Yes	1	5	6
99	R:R:Q227	R:R:T204	4.25	Yes	Yes	1	7	6
100	R:R:H421	R:R:T204	9.58	Yes	Yes	1	6	6
101	R:R:F425	R:R:T204	7.78	Yes	Yes	1	7	6
102	R:R:I210	R:R:L206	7.14	No	No	0	6	4
103	R:R:L206	R:R:W213	4.56	No	Yes	1	4	7
104	R:R:L206	R:R:P214	6.57	No	No	1	4	3
105	R:R:D207	R:R:N208	4.04	No	Yes	0	5	5
106	R:R:N208	R:R:P418	9.77	Yes	No	1	5	5
107	R:R:I209	R:R:I210	10.3	No	No	0	5	6
108	R:R:G212	R:R:W307	5.63	No	Yes	0	5	4
109	R:R:P214	R:R:W213	4.05	No	Yes	1	3	7
110	R:R:F215	R:R:W213	5.01	No	Yes	0	7	7
111	R:R:C220	R:R:W213	7.84	No	Yes	0	9	7
112	R:R:S223	R:R:W213	7.41	No	Yes	1	5	7
113	R:R:F215	R:R:M219	9.95	No	No	0	7	6
114	R:R:K221	R:R:N217	15.39	No	No	0	7	3
115	R:R:N217	R:R:V286	8.87	No	No	0	3	5
116	R:R:C220	R:R:C308	7.28	No	No	0	9	9
117	R:R:K221	R:R:L284	8.46	No	No	0	7	5
118	R:R:G224	R:R:S223	3.71	No	No	0	4	5
119	R:R:I229	R:R:L225	7.14	No	No	0	7	6
120	R:R:A281	R:R:L225	6.3	No	No	0	5	6
121	R:R:G228	R:R:M277	5.24	No	No	0	6	8
122	R:R:V231	R:R:W389	8.58	No	Yes	0	7	8
123	R:R:A232	R:R:F236	4.16	No	Yes	0	6	6
124	R:R:A233	R:R:W270	3.89	No	No	0	8	9
125	R:R:F236	R:R:V235	3.93	Yes	Yes	0	6	8
126	R:R:I329	R:R:V235	4.61	No	Yes	0	6	8
127	R:R:P333	R:R:V235	3.53	No	Yes	0	9	8
128	R:R:F385	R:R:V235	3.93	Yes	Yes	0	9	8
129	R:R:F236	R:R:I269	3.77	Yes	No	0	6	8
130	R:R:F236	R:R:L272	3.65	Yes	No	0	6	4
131	R:R:F236	R:R:I276	3.77	Yes	No	0	6	5
132	R:R:L238	R:R:N427	4.12	No	Yes	1	9	9
133	R:R:L238	R:R:N431	4.12	No	Yes	1	9	9
134	R:R:L238	R:R:Y435	3.52	No	Yes	0	9	9
135	R:R:P333	R:R:V239	3.53	No	No	0	9	7
136	R:R:I241	R:R:R245	3.76	No	No	0	9	9
137	R:R:I241	R:R:Y435	6.04	No	Yes	0	9	9
138	R:R:A242	R:R:Y341	5.34	No	Yes	0	8	9
139	R:R:Q247	R:R:V243	5.73	No	No	0	4	7
140	R:R:R245	R:R:Y341	5.14	No	Yes	0	9	9
141	R:R:M377	R:R:R245	3.72	No	No	0	8	9
142	R:R:F246	R:R:V250	14.42	Yes	No	3	8	7
143	R:R:F246	R:R:Y251	6.19	Yes	Yes	3	8	6
144	R:R:F246	R:R:M340	7.46	Yes	No	0	8	7
145	R:R:F246	R:R:R343	11.76	Yes	No	3	8	6
146	R:R:K254	R:R:Q247	4.07	Yes	No	0	5	4
147	R:R:I344	R:R:V249	6.14	No	No	0	9	9
148	R:R:L348	R:R:V249	4.47	No	No	0	9	9
149	R:R:V250	R:R:Y251	16.4	No	Yes	3	7	6
150	R:R:R343	R:R:V250	3.92	No	No	3	6	7
151	R:R:K254	R:R:Y251	9.55	Yes	Yes	0	5	6
152	R:R:R343	R:R:Y251	5.14	No	Yes	3	6	6
153	R:R:K256	R:R:L257	8.46	No	No	0	5	6
154	R:R:I259	R:R:K260	4.36	No	No	0	4	5
155	R:R:F263	R:R:M267	7.46	No	No	0	4	4
156	R:R:M277	R:R:S280	4.6	No	No	0	8	6
157	R:R:P279	R:R:Y321	6.95	No	No	0	9	8
158	R:R:H285	R:R:M283	5.25	No	Yes	0	5	5
159	R:R:M283	R:R:W312	16.29	Yes	No	0	5	5
160	R:R:M283	R:R:P313	11.74	Yes	No	0	5	8
161	R:R:D311	R:R:H285	7.56	No	No	0	4	5
162	R:R:Q287	R:R:R309	18.69	No	No	0	2	4
163	R:R:E289	R:R:W307	9.81	Yes	Yes	0	3	4
164	R:R:E289	R:R:R309	6.98	Yes	No	4	3	4
165	R:R:R293	R:R:T302	12.94	Yes	No	2	4	3
166	R:R:P304	R:R:R293	7.21	No	Yes	0	4	4
167	R:R:V294	R:R:V305	4.81	No	No	0	3	4
168	R:R:N300	R:R:R295	4.82	No	No	0	3	4
169	R:R:L296	R:R:S298	9.01	Yes	No	0	3	2
170	R:R:K301	R:R:L296	9.87	No	Yes	0	1	3
171	R:R:L296	R:R:S303	6.01	Yes	No	0	3	3
172	R:R:V305	R:R:W307	14.71	No	Yes	0	4	4
173	R:R:E310	R:R:W312	8.72	No	No	6	5	5
174	R:R:E310	R:R:R318	12.79	No	No	6	5	4
175	R:R:R318	R:R:W312	17.99	No	No	6	4	5
176	R:R:N314	R:R:P313	8.15	No	No	0	4	8
177	R:R:E316	R:R:N314	6.57	No	No	7	1	4
178	R:R:M317	R:R:N314	7.01	No	No	7	4	4
179	R:R:E316	R:R:M317	6.77	No	No	7	1	4
180	R:R:R318	R:R:Y321	4.12	No	No	0	4	8
181	R:R:I320	R:R:T323	4.56	No	No	0	5	5
182	R:R:L325	R:R:Y321	16.41	No	No	0	5	8
183	R:R:D400	R:R:T322	11.56	Yes	No	0	5	6
184	R:R:M397	R:R:T323	4.52	No	No	8	6	5
185	R:R:T323	R:R:Y401	4.99	No	No	8	5	5
186	R:R:I329	R:R:L325	5.71	No	No	0	6	5
187	R:R:F326	R:R:L331	9.74	No	No	0	6	5
188	R:R:F326	R:R:W393	7.02	No	Yes	0	6	7
189	R:R:F326	R:R:M397	12.44	No	No	0	6	6
190	R:R:I329	R:R:W393	11.74	No	Yes	0	6	7
191	R:R:F385	R:R:Y330	5.16	Yes	No	0	9	8
192	R:R:W393	R:R:Y330	8.68	Yes	No	0	7	8
193	R:R:F385	R:R:L334	4.87	Yes	No	0	9	7
194	R:R:L336	R:R:M340	8.48	No	No	0	7	7
195	R:R:I337	R:R:Y341	6.04	No	Yes	0	9	9
196	R:R:L378	R:R:Y341	9.38	No	Yes	0	8	9
197	R:R:F349	R:R:I346	3.77	No	No	9	4	3
198	R:R:I346	R:R:R350	5.01	No	No	9	3	5
199	R:R:K371	R:R:L348	8.46	No	No	0	7	9
200	R:R:F349	R:R:R350	11.76	No	No	9	4	5
201	R:R:K370	R:R:Q372	8.14	No	No	0	7	5
202	R:R:I375	R:R:K371	4.36	Yes	No	0	7	7
203	R:R:I375	R:R:Q372	5.49	Yes	No	10	7	5
204	R:R:K376	R:R:Q372	5.42	No	No	10	7	5
205	R:R:E440	R:R:K373	10.8	No	No	0	5	7
206	R:R:I374	R:R:I375	4.42	No	Yes	0	8	7
207	R:R:I375	R:R:K376	5.82	Yes	No	10	7	7
208	R:R:L378	R:R:M377	4.24	No	No	0	8	8
209	R:R:F438	R:R:M377	17.42	No	No	0	7	8
210	R:R:L379	R:R:L383	6.92	No	No	0	5	6
211	R:R:V381	R:R:Y435	6.31	No	Yes	0	8	9
212	R:R:L384	R:R:S388	6.01	No	No	0	7	9
213	R:R:F385	R:R:W389	6.01	Yes	Yes	1	9	8
214	R:R:F385	R:R:N427	4.83	Yes	Yes	1	9	9
215	R:R:L392	R:R:W389	6.83	No	Yes	1	6	8
216	R:R:W389	R:R:W393	6.56	Yes	Yes	1	8	7
217	R:R:A424	R:R:W389	5.19	No	Yes	1	7	8
218	R:R:N427	R:R:W389	6.78	Yes	Yes	1	9	8
219	R:R:A424	R:R:L392	4.73	No	No	1	7	6
220	R:R:M396	R:R:W393	9.31	Yes	Yes	1	6	7
221	R:R:L395	R:R:Y417	8.21	No	Yes	0	6	5
222	R:R:M396	R:R:Y417	3.59	Yes	Yes	1	6	5
223	R:R:M397	R:R:Y401	16.76	No	No	8	6	5
224	R:R:D400	R:R:S399	4.42	Yes	No	0	5	4
225	R:R:E408	R:R:L404	5.3	No	No	0	3	5
226	R:R:L404	R:R:L409	4.15	No	No	0	5	4
227	R:R:P406	R:R:S405	5.34	No	No	0	2	3
228	R:R:L409	R:R:N413	6.87	No	No	0	4	5
229	R:R:I411	R:R:Q410	4.12	No	No	0	2	1
230	R:R:I411	R:R:Y415	3.63	No	No	0	2	3
231	R:R:I412	R:R:I416	7.36	No	No	0	4	5
232	R:R:I414	R:R:Y415	13.3	No	No	0	4	3
233	R:R:H421	R:R:Y417	15.24	Yes	Yes	1	6	5
234	R:R:F419	R:R:L423	3.65	No	No	0	5	8
235	R:R:F425	R:R:H421	9.05	Yes	Yes	1	7	6
236	R:R:G426	R:R:S429	3.71	No	No	0	6	7
237	R:R:N427	R:R:N431	6.81	Yes	Yes	1	9	9
238	R:R:F437	R:R:I433	5.02	No	No	0	6	7
239	R:R:I434	R:R:Y435	4.84	No	Yes	0	9	9
240	R:R:F438	R:R:I434	8.79	No	No	0	7	9
241	R:R:N439	R:R:N441	12.26	No	No	0	8	7
242	R:R:F442	R:R:N439	12.08	Yes	No	0	9	8
243	R:R:E440	R:R:R443	12.79	No	No	0	5	9
244	R:R:D400	R:R:Y401	3.45	Yes	No	0	5	5
245	R:R:A190	R:R:V168	3.39	No	No	0	9	9
246	R:R:E289	R:R:Y292	3.37	Yes	No	0	3	1
247	R:R:K254	R:R:P255	3.35	Yes	No	0	5	5
248	R:R:L390	R:R:P391	3.28	No	No	0	7	9
249	R:R:L392	R:R:P391	3.28	No	No	0	6	9
250	R:R:L423	R:R:P391	3.28	No	No	0	8	9
251	R:R:N407	R:R:P406	3.26	No	No	0	1	2
252	R:R:A240	R:R:I269	3.25	No	No	0	7	8
253	R:R:C169	R:R:M173	3.24	No	No	0	7	4
254	R:R:C248	R:R:K256	3.23	No	No	0	8	5
255	R:R:A242	R:R:M340	3.22	No	No	0	8	7
256	R:R:P144	R:R:Q143	3.16	No	No	0	3	6
257	R:R:T258	R:R:T261	3.14	No	No	0	8	6
258	R:R:I149	R:R:V146	3.07	No	No	0	5	6
259	R:R:I171	R:R:V172	3.07	No	No	0	8	8
260	R:R:I268	R:R:V264	3.07	No	No	0	4	3
261	R:R:I434	R:R:V430	3.07	No	No	0	9	6
262	R:R:I186	R:R:T182	3.04	No	No	0	8	8
263	R:R:I259	R:R:T258	3.04	No	No	0	4	8
264	R:R:M283	R:R:V282	3.04	Yes	No	0	5	5
265	R:R:L160	R:R:S429	3	No	No	0	6	7
266	R:R:L189	R:R:S234	3	Yes	No	0	9	9
267	R:R:K221	R:R:T218	3	No	No	0	7	2
268	R:R:L384	R:R:V430	2.98	No	No	0	7	6
269	R:R:N328	R:R:V324	2.96	No	No	0	4	5
270	R:R:I151	R:R:I152	2.94	No	No	0	6	5
271	R:R:I374	R:R:K373	2.91	No	No	0	8	7
272	R:R:K254	R:R:K256	2.87	Yes	No	0	5	5
273	R:R:E408	R:R:S405	2.87	No	No	0	3	3
274	R:R:I152	R:R:L156	2.85	No	No	0	5	4
275	R:R:I191	R:R:L194	2.85	No	No	0	7	8
276	R:R:I191	R:R:L195	2.85	No	No	0	7	7
277	R:R:I268	R:R:L272	2.85	No	No	0	4	4
278	R:R:I386	R:R:L334	2.85	No	No	0	6	7
279	R:R:I344	R:R:L378	2.85	No	No	0	9	8
280	R:R:I386	R:R:L387	2.85	No	No	0	6	6
281	R:R:I412	R:R:L395	2.85	No	No	0	4	6
282	R:R:A273	R:R:F236	2.77	No	Yes	0	8	6
283	R:R:D400	R:R:K319	2.77	Yes	No	0	5	4
284	R:R:L383	R:R:L387	2.77	No	No	0	6	6
285	R:R:K319	R:R:Q315	2.71	No	No	0	4	2
286	R:R:E288	R:R:K290	2.7	No	No	0	3	3
287	R:R:A211	R:R:Y139	2.67	No	Yes	0	4	4
288	R:R:A420	R:R:Y417	2.67	No	Yes	0	7	5
289	R:R:H179	R:R:K176	2.62	No	No	0	8	6
290	R:R:H285	R:R:L284	2.57	No	No	0	5	5
291	R:R:F438	R:R:I380	2.51	No	No	0	7	6
292	R:R:I229	R:R:W270	2.35	No	No	0	7	9
293	R:R:L205	R:R:Y154	2.34	No	No	0	6	7
294	R:R:N297	R:R:Y139	2.33	No	Yes	0	2	4
295	R:R:L141	R:R:W307	2.28	No	Yes	0	4	4
296	R:R:E288	R:R:Y306	2.24	No	No	0	3	5
297	R:R:A332	R:R:P333	1.87	No	No	0	6	9
298	R:R:G164	R:R:V167	1.84	No	No	0	8	6
299	R:R:A190	R:R:C169	1.81	No	No	0	9	7
300	R:R:P279	R:R:S278	1.78	No	No	0	9	5
301	R:R:P304	R:R:S303	1.78	No	No	0	4	3
302	R:R:P432	R:R:V168	1.77	No	No	0	9	9
303	R:R:G345	R:R:I344	1.76	No	No	0	6	9
304	R:R:I433	R:R:P432	1.69	No	No	0	7	9
305	R:R:A147	R:R:I151	1.62	No	No	0	4	6
306	R:R:A148	R:R:I152	1.62	No	No	0	5	5
307	R:R:S347	R:R:V249	1.62	No	No	0	5	9
308	R:R:A382	R:R:I386	1.62	No	No	0	8	6
309	R:R:T275	R:R:V271	1.59	No	No	0	4	5
310	R:R:A262	R:R:L184	1.58	No	No	0	8	5
311	R:R:A402	R:R:L398	1.58	No	No	0	3	5
312	R:R:A327	R:R:N328	1.56	No	No	0	5	4
313	R:R:I274	R:R:S278	1.55	No	No	0	4	5
314	R:R:I339	R:R:S335	1.55	No	No	0	5	4
315	R:R:I171	R:R:V167	1.54	No	No	0	8	6
316	R:R:I222	R:R:V226	1.54	No	No	0	6	5
317	R:R:I320	R:R:V324	1.54	No	No	0	5	5
318	R:R:M162	R:R:T166	1.51	No	No	0	6	4
319	R:R:F442	R:R:G436	1.51	Yes	No	0	9	7
320	R:R:L331	R:R:S335	1.5	No	No	0	5	4
321	R:R:L334	R:R:V338	1.49	No	No	0	7	5
322	R:R:L390	R:R:T394	1.47	No	No	0	7	7
323	R:R:L398	R:R:T394	1.47	No	No	0	5	7
324	R:R:Q299	R:R:S298	1.44	No	No	0	1	2
325	R:R:P252	R:R:Y251	1.39	No	Yes	0	8	6
326	R:R:V286	R:R:Y306	1.26	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F8	5.632	5	1	0
2	L:L:?9	6.48	4	1	0
3	R:R:Y136	11.8625	4	2	4
4	R:R:Y139	5.285	4	0	4
5	R:R:F185	4.445	4	0	8
6	R:R:N188	7.345	4	0	9
7	R:R:L189	6.78	5	1	9
8	R:R:D193	7.19	5	1	9
9	R:R:M201	6.64	6	0	7
10	R:R:T204	6.19	6	1	6
11	R:R:N208	6.3625	4	1	5
12	R:R:W213	6.18167	6	1	7
13	R:R:Q227	9.175	4	1	7
14	R:R:V235	4	4	0	8
15	R:R:F236	3.675	6	0	6
16	R:R:F246	9.9575	4	3	8
17	R:R:Y251	7.734	5	3	6
18	R:R:K254	4.96	4	0	5
19	R:R:M283	9.08	4	0	5
20	R:R:E289	6.22	4	4	3
21	R:R:R293	14.1075	4	2	4
22	R:R:L296	7.1025	4	0	3
23	R:R:W307	9.65	5	0	4
24	R:R:Y341	6.475	4	0	9
25	R:R:I375	5.0225	4	10	7
26	R:R:F385	4.96	5	1	9
27	R:R:W389	6.65833	6	1	8
28	R:R:W393	7.88667	6	1	7
29	R:R:M396	5.0875	4	1	6
30	R:R:D400	5.55	4	0	5
31	R:R:Y417	8.06667	6	1	5
32	R:R:H421	10.0575	4	1	6
33	R:R:F425	8.48333	6	1	7
34	R:R:N427	5.635	4	1	9
35	R:R:N431	8.515	4	1	9
36	R:R:Y435	5.1775	4	0	9
37	R:R:F442	5.928	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:N3	R:R:W307	30.3284	15.82	No	Yes	0	0	4
2	L:L:N3	R:R:D207	31.2288	12.12	No	No	0	0	5
3	L:L:P5	R:R:Y417	11.0909	12.52	No	Yes	0	0	5
4	R:R:H421	R:R:Y417	95.355	15.24	Yes	Yes	1	6	5
5	R:R:H421	R:R:T204	58.2556	9.58	Yes	Yes	1	6	6
6	R:R:N208	R:R:T204	45.1817	4.39	Yes	Yes	1	5	6
7	R:R:D207	R:R:N208	33.1976	4.04	No	Yes	0	5	5
8	R:R:M396	R:R:Y417	98.6244	3.59	Yes	Yes	1	6	5
9	R:R:M396	R:R:W393	97.5417	9.31	Yes	Yes	1	6	7
10	R:R:Q227	R:R:T204	22.1389	4.25	Yes	Yes	1	7	6
11	R:R:V305	R:R:W307	20.2558	14.71	No	Yes	0	4	4
12	R:R:V294	R:R:V305	19.1911	4.81	No	No	0	3	4
13	R:R:V294	R:R:Y139	18.1191	12.62	No	Yes	0	3	4
14	R:R:L296	R:R:Y139	14.8605	3.52	Yes	Yes	0	3	4
15	R:R:L296	R:R:S303	10.4156	6.01	Yes	No	0	3	3
16	R:R:I203	R:R:Q227	40.0007	16.47	No	Yes	1	6	7
17	R:R:I203	R:R:W213	33.6871	8.22	No	Yes	1	6	7
18	R:R:L206	R:R:W213	21.3313	4.56	No	Yes	1	4	7
19	R:R:I210	R:R:L206	19.2482	7.14	No	No	0	6	4
20	R:R:I209	R:R:I210	17.2902	10.3	No	No	0	5	6
21	R:R:I209	R:R:Y140	15.1499	10.88	No	No	0	5	5
22	R:R:A147	R:R:Y140	13.006	4	No	No	0	4	5
23	R:R:F150	R:R:N208	12.613	7.25	No	Yes	1	5	5
24	R:R:F150	R:R:H142	11.5339	16.97	No	No	0	5	5
25	R:R:F425	R:R:M201	21.56	12.44	Yes	Yes	0	7	7
26	R:R:A147	R:R:I151	10.8586	1.62	No	No	0	4	6
27	R:R:W389	R:R:W393	89.6059	6.56	Yes	Yes	1	8	7
28	R:R:N427	R:R:W389	86.6545	6.78	Yes	Yes	1	9	8
29	R:R:L238	R:R:N427	88.9056	4.12	No	Yes	1	9	9
30	R:R:L238	R:R:Y435	100	3.52	No	Yes	0	9	9
31	R:R:I241	R:R:Y435	78.5758	6.04	No	Yes	0	9	9
32	R:R:F185	R:R:I241	30.6178	5.02	Yes	No	0	8	9
33	R:R:D244	R:R:F185	26.4408	3.58	No	Yes	0	9	8
34	R:R:D244	R:R:T182	25.3796	5.78	No	No	0	9	8
35	R:R:I186	R:R:T182	24.2434	3.04	No	No	0	8	8
36	R:R:I186	R:R:N183	23.0964	4.25	No	No	0	8	9
37	R:R:F442	R:R:N183	20.7811	6.04	Yes	No	0	9	9
38	R:R:N427	R:R:N431	18.4514	6.81	Yes	Yes	1	9	9
39	R:R:D193	R:R:N431	20.7453	10.77	Yes	Yes	1	9	9
40	R:R:D193	R:R:N165	14.3602	6.73	Yes	No	0	9	9
41	R:R:I241	R:R:R245	57.3909	3.76	No	No	0	9	9
42	R:R:R245	R:R:Y341	39.9936	5.14	No	Yes	0	9	9
43	R:R:A242	R:R:Y341	23.611	5.34	No	Yes	0	8	9
44	R:R:A242	R:R:M340	22.4854	3.22	No	No	0	8	7
45	R:R:F246	R:R:M340	20.213	7.46	Yes	No	0	8	7
46	R:R:F246	R:R:Y251	16.6506	6.19	Yes	Yes	3	8	6
47	R:R:K254	R:R:Y251	14.396	9.55	Yes	Yes	0	5	6
48	R:R:I329	R:R:W393	36.1739	11.74	No	Yes	0	6	7
49	R:R:I329	R:R:V235	24.3685	4.61	No	Yes	0	6	8
50	R:R:F236	R:R:V235	15.1678	3.93	Yes	Yes	0	6	8
51	R:R:I329	R:R:L325	37.9426	5.71	No	No	0	6	5
52	R:R:L325	R:R:Y321	36.4276	16.41	No	No	0	5	8
53	R:R:R318	R:R:Y321	30.3534	4.12	No	No	0	4	8
54	R:R:R318	R:R:W312	27.3484	17.99	No	No	6	4	5
55	R:R:M283	R:R:W312	26.0085	16.29	Yes	No	0	5	5
56	R:R:H285	R:R:M283	16.4684	5.25	No	Yes	0	5	5
57	R:R:H285	R:R:L284	13.2311	2.57	No	No	0	5	5
58	R:R:K221	R:R:L284	11.6018	8.46	No	No	0	7	5
59	R:R:M377	R:R:R245	17.6332	3.72	No	No	0	8	9
60	R:R:I434	R:R:Y435	21.9673	4.84	No	Yes	0	9	9
61	R:R:F438	R:R:I434	18.2799	8.79	No	No	0	7	9
62	R:R:F438	R:R:M377	16.7649	17.42	No	No	0	7	8
63	R:R:L378	R:R:Y341	17.626	9.38	No	Yes	0	8	9
64	R:R:I344	R:R:L378	44.635	2.85	No	No	0	9	8
65	R:R:L378	R:R:M377	31.2467	4.24	No	No	0	8	8
66	R:R:I344	R:R:V249	38.3571	6.14	No	No	0	9	9
67	R:R:L348	R:R:V249	31.9791	4.47	No	No	0	9	9
68	R:R:F326	R:R:W393	19.1482	7.02	No	Yes	0	6	7
69	R:R:F326	R:R:M397	14.5317	12.44	No	No	0	6	6
70	R:R:F385	R:R:L334	12.2021	4.87	Yes	No	0	9	7
71	R:R:K371	R:R:L348	28.7848	8.46	No	No	0	7	9
72	R:R:I375	R:R:K371	25.8013	4.36	Yes	No	0	7	7
73	R:R:I374	R:R:I375	12.9239	4.42	No	Yes	0	8	7
74	L:L:?9	R:R:H421	18.2299	6.36	Yes	Yes	1	0	6
75	L:L:?9	R:R:Q227	18.7158	9.88	Yes	Yes	1	0	7
76	R:R:F425	R:R:H421	18.38	9.05	Yes	Yes	1	7	6
77	R:R:F385	R:R:V235	19.0588	3.93	Yes	Yes	0	9	8
78	R:R:L238	R:R:N431	11.7376	4.12	No	Yes	1	9	9
79	R:R:F385	R:R:N427	21.0634	4.83	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:E289	4.72	4	No	Yes	0	3	0	1
L:L:P2	R:R:R309	4.32	4	No	No	0	4	0	1
L:L:N3	R:R:D207	12.12	0	No	No	0	5	0	1
L:L:N3	R:R:W307	15.82	0	No	Yes	0	4	0	1
L:L:L4	R:R:N413	4.12	0	No	No	0	5	0	1
L:L:P5	R:R:N413	6.52	0	No	No	0	5	0	1
L:L:P5	R:R:Y417	12.52	0	No	Yes	0	5	0	1
L:L:Q6	R:R:D207	11.75	0	No	No	0	5	0	1
L:L:R7	R:R:M396	3.72	1	No	Yes	0	6	0	1
L:L:R7	R:R:Y417	6.17	1	No	Yes	0	5	0	1
L:L:F8	R:R:V231	6.55	1	Yes	No	0	7	0	1
L:L:F8	R:R:M277	7.46	1	Yes	No	0	8	0	1
L:L:F8	R:R:W393	4.01	1	Yes	Yes	0	7	0	1
L:L:F8	R:R:M396	3.73	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:T204	3.65	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:Q227	9.88	1	Yes	Yes	0	7	0	1
L:L:?9	R:R:H421	6.36	1	Yes	Yes	0	6	0	1
L:L:?9	R:R:F425	6.03	1	Yes	Yes	0	7	0	1
R:R:T204	R:R:Y154	7.49	1	Yes	No	6	7	1	2
R:R:F425	R:R:Y154	7.22	1	Yes	No	7	7	1	2
R:R:C200	R:R:Q227	6.1	0	No	Yes	7	7	2	1
R:R:C200	R:R:F425	8.38	0	No	Yes	7	7	2	1
R:R:F425	R:R:M201	12.44	1	Yes	Yes	7	7	1	2
R:R:I203	R:R:Q227	16.47	1	No	Yes	6	7	2	1
R:R:N208	R:R:T204	4.39	1	Yes	Yes	5	6	2	1
R:R:Q227	R:R:T204	4.25	1	Yes	Yes	7	6	1	1
R:R:H421	R:R:T204	9.58	1	Yes	Yes	6	6	1	1
R:R:F425	R:R:T204	7.78	1	Yes	Yes	7	6	1	1
R:R:D207	R:R:N208	4.04	0	No	Yes	5	5	1	2
R:R:G212	R:R:W307	5.63	0	No	Yes	5	4	2	1
R:R:G228	R:R:M277	5.24	0	No	No	6	8	2	1
R:R:V231	R:R:W389	8.58	0	No	Yes	7	8	1	2
R:R:M277	R:R:S280	4.6	0	No	No	8	6	1	2
R:R:Q287	R:R:R309	18.69	0	No	No	2	4	2	1
R:R:E289	R:R:W307	9.81	4	Yes	Yes	3	4	1	1
R:R:E289	R:R:R309	6.98	4	Yes	No	3	4	1	1
R:R:V305	R:R:W307	14.71	0	No	Yes	4	4	2	1
R:R:F326	R:R:W393	7.02	0	No	Yes	6	7	2	1
R:R:I329	R:R:W393	11.74	0	No	Yes	6	7	2	1
R:R:W393	R:R:Y330	8.68	1	Yes	No	7	8	1	2
R:R:W389	R:R:W393	6.56	1	Yes	Yes	8	7	2	1
R:R:M396	R:R:W393	9.31	1	Yes	Yes	6	7	1	1
R:R:L395	R:R:Y417	8.21	0	No	Yes	6	5	2	1
R:R:M396	R:R:Y417	3.59	1	Yes	Yes	6	5	1	1
R:R:L409	R:R:N413	6.87	0	No	No	4	5	2	1
R:R:H421	R:R:Y417	15.24	1	Yes	Yes	6	5	1	1
R:R:F425	R:R:H421	9.05	1	Yes	Yes	7	6	1	1
R:R:E289	R:R:Y292	3.37	4	Yes	No	3	1	1	2
R:R:A420	R:R:Y417	2.67	0	No	Yes	7	5	2	1
R:R:L141	R:R:W307	2.28	0	No	Yes	4	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9M54_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	295
Number of Links	326
Number of Hubs	37
Number of Links mediated by Hubs	141
Number of Communities	10
Number of Nodes involved in Communities	58
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	80
Number Of Links MetaPath	79
Number of Shortest Paths	60228
Length Of Smallest Path	3
Average Path Length	15.5001
Length of Longest Path	38
Minimum Path Strength	1.47
Average Path Strength	7.00869
Maximum Path Strength	17.14
Minimum Path Correlation	0.7
Average Path Correlation	0.932094
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	48.7618
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.7136
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?9
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5X5
Sequence	>9M54_nogp_Chain_R N I T Y V N Y Y L H Q P Q V A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N K H M H T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G W P F G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y P F K P K L T I K T A F V I I M I I W V L A I T I M S P S A V M L H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A D L S P N E L Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JFY	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-	Gi1/β1/γ2	3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JFY (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-		3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JG0	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	-	-	-	2.91	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-	Gi1/β1/γ2	3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-		3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9M54_nogp.zip

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