psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q2	R:R:Q287	12.8	No	No	5	0	2
2	L:L:Q2	R:R:E289	6.37	No	Yes	5	0	3
3	L:L:F4	L:L:F6	5.36	Yes	Yes	4	0	0
4	L:L:F4	R:R:G212	3.01	Yes	No	0	0	5
5	L:L:F4	R:R:Y292	8.25	Yes	Yes	4	0	1
6	L:L:F4	R:R:V305	10.49	Yes	No	0	0	4
7	L:L:F4	R:R:W307	7.02	Yes	Yes	0	0	4
8	L:L:L5	L:L:Q7	6.65	No	No	0	0	0
9	L:L:L5	R:R:L409	4.15	No	No	0	0	4
10	L:L:L5	R:R:Q410	5.32	No	Yes	0	0	1
11	L:L:F6	R:R:L141	7.31	Yes	No	0	0	4
12	L:L:F6	R:R:Y292	6.19	Yes	Yes	4	0	1
13	L:L:F6	R:R:Q410	5.86	Yes	Yes	4	0	1
14	L:L:F6	R:R:I414	8.79	Yes	Yes	4	0	4
15	L:L:Q7	R:R:W307	9.86	No	Yes	0	0	4
16	L:L:P8	R:R:Y417	5.56	No	Yes	0	0	5
17	L:L:?12	L:L:Q9	3.29	Yes	No	1	0	0
18	L:L:Q9	R:R:W213	4.38	No	Yes	1	0	7
19	L:L:Q9	R:R:C220	4.58	No	Yes	1	0	9
20	L:L:F11	L:L:R10	6.41	Yes	Yes	0	0	0
21	L:L:R10	R:R:E310	8.14	Yes	Yes	2	0	5
22	L:L:R10	R:R:Y321	7.2	Yes	No	2	0	8
23	L:L:R10	R:R:T322	6.47	Yes	No	0	0	6
24	L:L:R10	R:R:M396	3.72	Yes	No	0	0	6
25	L:L:?12	L:L:F11	3.01	Yes	Yes	0	0	0
26	L:L:F11	R:R:V231	9.18	Yes	No	0	0	7
27	L:L:F11	R:R:W393	4.01	Yes	Yes	0	0	7
28	L:L:?12	R:R:T204	3.65	Yes	No	1	0	6
29	L:L:?12	R:R:Q227	3.29	Yes	Yes	0	0	7
30	L:L:?12	R:R:H421	9.55	Yes	Yes	1	0	6
31	R:R:I132	R:R:I134	2.94	No	Yes	3	1	3
32	R:R:I132	R:R:K290	2.91	No	Yes	3	1	3
33	R:R:I132	R:R:Y291	7.25	No	No	3	1	2
34	R:R:I134	R:R:Y136	8.46	Yes	No	3	3	4
35	R:R:I134	R:R:K290	4.36	Yes	Yes	3	3	3
36	R:R:I134	R:R:R293	3.76	Yes	Yes	3	3	4
37	R:R:T135	R:R:Y292	9.99	No	Yes	0	4	1
38	R:R:R293	R:R:Y136	3.09	Yes	No	3	4	4
39	R:R:R295	R:R:Y136	6.17	No	No	0	4	4
40	R:R:Y139	R:R:Y140	9.93	No	No	0	4	5
41	R:R:I210	R:R:Y140	3.63	No	No	0	6	5
42	R:R:H142	R:R:L141	3.86	No	No	0	5	4
43	R:R:F150	R:R:H142	6.79	Yes	No	0	5	5
44	R:R:H142	R:R:I414	3.98	No	Yes	0	5	4
45	R:R:P144	R:R:Q143	3.16	No	No	0	3	6
46	R:R:Q143	R:R:V146	2.87	No	No	0	6	6
47	R:R:I149	R:R:V146	3.07	No	No	0	5	6
48	R:R:F150	R:R:I149	5.02	Yes	No	0	5	5
49	R:R:F150	R:R:P418	8.67	Yes	No	0	5	5
50	R:R:I151	R:R:L205	2.85	No	No	7	6	6
51	R:R:I151	R:R:I209	2.94	No	No	7	6	5
52	R:R:S153	R:R:W422	11.12	No	Yes	0	5	6
53	R:R:L205	R:R:Y154	4.69	No	Yes	0	6	7
54	R:R:P418	R:R:Y154	2.78	No	Yes	0	5	7
55	R:R:H421	R:R:Y154	3.27	Yes	Yes	0	6	7
56	R:R:W422	R:R:Y154	4.82	Yes	Yes	0	6	7
57	R:R:I157	R:R:M201	4.37	Yes	Yes	0	7	7
58	R:R:I157	R:R:W422	11.74	Yes	Yes	0	7	6
59	R:R:G426	R:R:I157	5.29	No	Yes	0	6	7
60	R:R:F158	R:R:M162	3.73	No	No	0	6	6
61	R:R:F158	R:R:M201	3.73	No	Yes	0	6	7
62	R:R:F159	R:R:M162	3.73	No	No	8	4	6
63	R:R:F159	R:R:M163	4.98	No	No	8	4	5
64	R:R:L160	R:R:S429	6.01	No	No	0	6	7
65	R:R:C161	R:R:N165	4.72	No	Yes	0	8	9
66	R:R:C161	R:R:S429	5.16	No	No	0	8	7
67	R:R:M162	R:R:M163	2.89	No	No	8	6	5
68	R:R:G164	R:R:P432	4.06	No	No	0	8	9
69	R:R:A190	R:R:N165	3.13	No	Yes	0	9	9
70	R:R:D193	R:R:N165	5.39	Yes	Yes	0	9	9
71	R:R:L194	R:R:N165	6.87	No	Yes	0	8	9
72	R:R:N165	R:R:P432	9.77	Yes	No	0	9	9
73	R:R:A190	R:R:V168	3.39	No	No	0	9	9
74	R:R:C169	R:R:L187	3.17	No	No	0	7	6
75	R:R:C169	R:R:I191	3.27	No	No	0	7	7
76	R:R:I171	R:R:R174	5.01	No	No	0	8	6
77	R:R:F442	R:R:I171	5.02	Yes	No	0	9	8
78	R:R:M173	R:R:V172	3.04	No	No	10	4	8
79	R:R:L187	R:R:V172	5.96	No	No	10	6	8
80	R:R:L187	R:R:M173	2.83	No	No	10	6	4
81	R:R:M178	R:R:N175	16.83	No	No	0	8	7
82	R:R:M178	R:R:N183	5.61	No	No	0	8	9
83	R:R:N183	R:R:T180	8.77	No	No	0	9	8
84	R:R:A262	R:R:V181	3.39	No	No	0	8	7
85	R:R:D244	R:R:T182	7.23	No	No	0	9	8
86	R:R:I266	R:R:L184	4.28	Yes	No	0	8	5
87	R:R:A240	R:R:F185	5.55	No	Yes	0	7	8
88	R:R:F185	R:R:I241	3.77	Yes	No	0	8	9
89	R:R:F185	R:R:I265	3.77	Yes	No	0	8	6
90	R:R:F442	R:R:I186	3.77	Yes	No	0	9	8
91	R:R:N188	R:R:T237	8.77	No	No	0	9	8
92	R:R:I266	R:R:N188	2.83	Yes	No	0	8	9
93	R:R:N188	R:R:W270	4.52	No	No	0	9	9
94	R:R:D193	R:R:L189	8.14	Yes	Yes	9	9	9
95	R:R:L189	R:R:S234	3	Yes	No	9	9	9
96	R:R:L189	R:R:T237	11.79	Yes	No	0	9	8
97	R:R:L189	R:R:L238	5.54	Yes	No	0	9	9
98	R:R:A233	R:R:S192	3.42	No	No	0	8	9
99	R:R:S192	R:R:S234	4.89	No	No	0	9	9
100	R:R:D193	R:R:S234	5.89	Yes	No	9	9	9
101	R:R:D193	R:R:S428	7.36	Yes	No	0	9	9
102	R:R:D193	R:R:N431	5.39	Yes	No	0	9	9
103	R:R:I198	R:R:L194	4.28	No	No	0	5	8
104	R:R:L195	R:R:S230	4.5	No	No	0	7	7
105	R:R:C200	R:R:V196	3.42	No	No	0	7	8
106	R:R:S230	R:R:V196	3.23	No	No	0	7	8
107	R:R:S428	R:R:V196	3.23	No	No	0	9	8
108	R:R:G197	R:R:M201	5.24	No	Yes	0	7	7
109	R:R:F199	R:R:I198	5.02	No	No	0	6	5
110	R:R:F199	R:R:V226	7.87	No	No	0	6	5
111	R:R:C200	R:R:Q227	6.1	No	Yes	0	7	7
112	R:R:C200	R:R:F425	4.19	No	No	0	7	7
113	R:R:F425	R:R:M201	6.22	No	Yes	0	7	7
114	R:R:N208	R:R:T204	2.92	No	No	0	5	6
115	R:R:H421	R:R:T204	5.48	Yes	No	1	6	6
116	R:R:I209	R:R:L205	5.71	No	No	7	5	6
117	R:R:F215	R:R:L206	4.87	Yes	No	0	7	4
118	R:R:I209	R:R:I210	2.94	No	No	0	5	6
119	R:R:I210	R:R:P214	3.39	No	No	0	6	3
120	R:R:F215	R:R:W213	18.04	Yes	Yes	0	7	7
121	R:R:G216	R:R:W213	2.81	No	Yes	0	8	7
122	R:R:C220	R:R:W213	9.14	Yes	Yes	1	9	7
123	R:R:C308	R:R:W213	7.84	Yes	Yes	1	9	7
124	R:R:F215	R:R:P214	4.33	Yes	No	0	7	3
125	R:R:F215	R:R:M219	8.71	Yes	No	0	7	6
126	R:R:N217	R:R:T218	4.39	No	No	0	3	2
127	R:R:N217	R:R:V286	2.96	No	No	0	3	5
128	R:R:C220	R:R:L284	4.76	Yes	No	1	9	5
129	R:R:C220	R:R:C308	7.28	Yes	Yes	1	9	9
130	R:R:G224	R:R:S223	3.71	No	No	0	4	5
131	R:R:Q227	R:R:S223	4.33	Yes	No	0	7	5
132	R:R:A281	R:R:L225	4.73	No	No	0	5	6
133	R:R:G228	R:R:M277	3.49	No	Yes	0	6	8
134	R:R:I229	R:R:I274	5.89	No	No	0	7	4
135	R:R:I229	R:R:M277	2.92	No	Yes	0	7	8
136	R:R:A232	R:R:F236	4.16	No	No	0	6	6
137	R:R:A232	R:R:M277	3.22	No	Yes	0	6	8
138	R:R:A233	R:R:W270	7.78	No	No	0	8	9
139	R:R:I329	R:R:V235	4.61	No	No	0	6	8
140	R:R:P333	R:R:V235	3.53	No	No	0	9	8
141	R:R:F236	R:R:I269	5.02	No	No	0	6	8
142	R:R:F236	R:R:N328	4.83	No	No	0	6	4
143	R:R:P333	R:R:V239	3.53	No	No	0	9	7
144	R:R:L336	R:R:V239	2.98	No	No	0	7	7
145	R:R:I241	R:R:R245	3.76	No	No	0	9	9
146	R:R:A242	R:R:Y341	4	No	Yes	0	8	9
147	R:R:M340	R:R:V243	4.56	No	No	0	7	7
148	R:R:R245	R:R:Y341	9.26	No	Yes	0	9	9
149	R:R:F246	R:R:V250	11.8	Yes	No	0	8	7
150	R:R:F246	R:R:M340	9.95	Yes	No	0	8	7
151	R:R:F246	R:R:R343	3.21	Yes	No	0	8	6
152	R:R:F246	R:R:I344	3.77	Yes	Yes	0	8	9
153	R:R:I344	R:R:V249	6.14	Yes	No	0	9	9
154	R:R:S347	R:R:V250	4.85	No	No	0	5	7
155	R:R:F253	R:R:P252	8.67	No	No	0	6	8
156	R:R:K254	R:R:P255	3.35	No	No	0	5	5
157	R:R:K256	R:R:T258	3	No	No	0	5	8
158	R:R:K260	R:R:T258	3	No	No	0	5	8
159	R:R:T258	R:R:T261	6.28	No	No	0	8	6
160	R:R:F263	R:R:I266	6.28	No	Yes	0	4	8
161	R:R:F263	R:R:M267	11.2	No	No	0	4	4
162	R:R:I276	R:R:L272	2.85	No	No	0	5	4
163	R:R:I276	R:R:M277	8.75	No	Yes	0	5	8
164	R:R:I276	R:R:N328	8.5	No	No	0	5	4
165	R:R:L325	R:R:M277	2.83	No	Yes	0	5	8
166	R:R:M283	R:R:V282	3.04	Yes	No	0	5	5
167	R:R:E310	R:R:M283	6.77	Yes	Yes	2	5	5
168	R:R:M283	R:R:W312	6.98	Yes	Yes	2	5	5
169	R:R:M283	R:R:M317	4.33	Yes	No	2	5	4
170	R:R:C308	R:R:L284	3.17	Yes	No	1	9	5
171	R:R:V286	R:R:Y306	3.79	No	No	0	5	5
172	R:R:C308	R:R:V286	5.12	Yes	No	0	9	5
173	R:R:E289	R:R:Q287	3.82	Yes	No	5	3	2
174	R:R:Q287	R:R:R309	5.84	No	No	0	2	4
175	R:R:E288	R:R:P304	11	No	No	11	3	4
176	R:R:E288	R:R:Y306	12.35	No	No	11	3	5
177	R:R:E289	R:R:V305	2.85	Yes	No	0	3	4
178	R:R:E289	R:R:W307	4.36	Yes	Yes	0	3	4
179	R:R:K290	R:R:Y291	3.58	Yes	No	3	3	2
180	R:R:K290	R:R:R293	9.9	Yes	Yes	3	3	4
181	R:R:Q410	R:R:Y292	3.38	Yes	Yes	4	1	1
182	R:R:K301	R:R:L296	9.87	No	No	0	1	3
183	R:R:N297	R:R:S298	4.47	No	No	0	2	2
184	R:R:N300	R:R:T302	4.39	No	No	0	3	3
185	R:R:P304	R:R:S303	5.34	No	No	0	4	3
186	R:R:P304	R:R:Y306	2.78	No	No	11	4	5
187	R:R:R309	R:R:W307	20.99	No	Yes	0	4	4
188	R:R:D311	R:R:R309	3.57	No	No	0	4	4
189	R:R:E310	R:R:W312	15.27	Yes	Yes	2	5	5
190	R:R:E310	R:R:Y321	6.73	Yes	No	2	5	8
191	R:R:M317	R:R:W312	9.31	No	Yes	2	4	5
192	R:R:R318	R:R:W312	15.99	Yes	Yes	0	4	5
193	R:R:E316	R:R:N314	15.77	No	No	0	1	4
194	R:R:Q315	R:R:R318	14.02	No	Yes	0	2	4
195	R:R:K319	R:R:R318	6.19	No	Yes	0	4	4
196	R:R:D400	R:R:R318	8.34	No	Yes	0	5	4
197	R:R:L325	R:R:Y321	12.89	No	No	0	5	8
198	R:R:D400	R:R:T322	8.67	No	No	0	5	6
199	R:R:M397	R:R:T323	3.01	No	No	0	6	5
200	R:R:F326	R:R:Y330	7.22	No	No	6	6	8
201	R:R:F326	R:R:W393	9.02	No	Yes	6	6	7
202	R:R:I329	R:R:W393	8.22	No	Yes	0	6	7
203	R:R:L390	R:R:Y330	5.86	No	No	0	7	8
204	R:R:W393	R:R:Y330	9.65	Yes	No	6	7	8
205	R:R:I386	R:R:L334	7.14	No	No	0	6	7
206	R:R:I337	R:R:Y341	4.84	No	Yes	0	9	9
207	R:R:L378	R:R:Y341	15.24	No	Yes	0	8	9
208	R:R:R343	R:R:S347	3.95	No	No	0	6	5
209	R:R:G345	R:R:I344	3.53	No	Yes	0	6	9
210	R:R:I344	R:R:L378	2.85	Yes	No	0	9	8
211	R:R:K371	R:R:L348	4.23	No	No	0	7	9
212	R:R:K371	R:R:V367	9.11	No	No	0	7	4
213	R:R:R369	R:R:S368	7.91	No	No	0	5	4
214	R:R:K370	R:R:S368	4.59	No	No	0	7	4
215	R:R:I374	R:R:L378	2.85	No	No	0	8	8
216	R:R:F438	R:R:M377	4.98	No	No	0	7	8
217	R:R:L384	R:R:S388	3	No	No	0	7	9
218	R:R:F385	R:R:W389	6.01	No	Yes	0	9	8
219	R:R:N427	R:R:S388	8.94	No	No	0	9	9
220	R:R:W389	R:R:W393	6.56	Yes	Yes	0	8	7
221	R:R:N427	R:R:W389	14.69	No	Yes	0	9	8
222	R:R:L390	R:R:T394	4.42	No	No	0	7	7
223	R:R:L392	R:R:M396	4.24	No	No	0	6	6
224	R:R:M396	R:R:W393	4.65	No	Yes	0	6	7
225	R:R:I416	R:R:L395	7.14	No	No	0	5	6
226	R:R:L395	R:R:Y417	8.21	No	Yes	0	6	5
227	R:R:L398	R:R:L404	4.15	No	Yes	12	5	5
228	R:R:E408	R:R:L404	14.58	No	Yes	0	3	5
229	R:R:P406	R:R:S405	5.34	No	No	0	2	3
230	R:R:N407	R:R:S405	4.47	No	No	0	1	3
231	R:R:E408	R:R:S405	4.31	No	No	0	3	3
232	R:R:I414	R:R:Q410	4.12	Yes	Yes	4	4	1
233	R:R:I411	R:R:Y415	4.84	No	No	0	2	3
234	R:R:I412	R:R:N413	2.83	No	No	0	4	5
235	R:R:I412	R:R:I416	8.83	No	No	0	4	5
236	R:R:N413	R:R:Y417	4.65	No	Yes	0	5	5
237	R:R:I414	R:R:Y415	9.67	Yes	No	0	4	3
238	R:R:H421	R:R:Y417	3.27	Yes	Yes	0	6	5
239	R:R:F425	R:R:H421	7.92	No	Yes	0	7	6
240	R:R:L423	R:R:W422	4.56	No	Yes	0	8	6
241	R:R:F442	R:R:G436	4.52	Yes	No	0	9	7
242	R:R:F437	R:R:F438	4.29	No	No	0	6	7
243	R:R:E440	R:R:N439	5.26	No	No	13	5	8
244	R:R:N439	R:R:N441	6.81	No	No	13	8	7
245	R:R:F442	R:R:N439	4.83	Yes	No	0	9	8
246	R:R:E440	R:R:N441	6.57	No	No	13	5	7
247	R:R:A262	R:R:F185	2.77	No	Yes	0	8	8
248	R:R:L383	R:R:L387	2.77	No	No	0	6	6
249	R:R:L404	R:R:L409	2.77	Yes	No	0	5	4
250	R:R:I203	R:R:Q227	2.74	No	Yes	0	6	7
251	R:R:E316	R:R:M317	2.71	No	No	0	1	4
252	R:R:K376	R:R:Q372	2.71	No	No	0	7	5
253	R:R:P313	R:R:W312	2.7	No	Yes	0	8	5
254	R:R:H179	R:R:I259	2.65	No	No	0	8	4
255	R:R:F442	R:R:V172	2.62	Yes	No	0	9	8
256	R:R:R293	R:R:T302	2.59	Yes	No	0	4	3
257	R:R:A424	R:R:W389	2.59	No	Yes	0	7	8
258	R:R:S399	R:R:Y417	2.54	No	Yes	0	4	5
259	R:R:V137	R:R:Y292	2.52	No	Yes	0	2	1
260	R:R:V250	R:R:Y251	2.52	No	No	0	7	6
261	R:R:F185	R:R:I266	2.51	Yes	Yes	0	8	8
262	R:R:I346	R:R:R343	2.51	No	No	0	3	6
263	R:R:F442	R:R:M178	2.49	Yes	No	0	9	8
264	R:R:F326	R:R:L331	2.44	No	No	0	6	5
265	R:R:F385	R:R:L334	2.44	No	No	0	9	7
266	R:R:I241	R:R:Y435	2.42	No	No	0	9	9
267	R:R:I434	R:R:Y435	2.42	No	No	0	9	9
268	R:R:M397	R:R:Y401	2.39	No	No	0	6	5
269	R:R:Q247	R:R:Y251	2.25	No	No	0	4	6
270	R:R:F150	R:R:F419	2.14	Yes	No	0	5	5
271	R:R:F155	R:R:F158	2.14	No	No	0	4	6
272	R:R:A211	R:R:G212	1.95	No	No	0	4	5
273	R:R:A332	R:R:P333	1.87	No	No	0	6	9
274	R:R:A420	R:R:P391	1.87	No	No	0	7	9
275	R:R:G224	R:R:S280	1.86	No	No	0	4	6
276	R:R:G164	R:R:V167	1.84	No	No	0	8	6
277	R:R:A190	R:R:C169	1.81	No	No	0	9	7
278	R:R:A232	R:R:A273	1.79	No	No	0	6	8
279	R:R:P279	R:R:S278	1.78	No	No	0	9	5
280	R:R:G345	R:R:I375	1.76	No	No	0	6	7
281	R:R:G345	R:R:L348	1.71	No	No	0	6	9
282	R:R:A211	R:R:V294	1.7	No	No	0	4	3
283	R:R:M201	R:R:P202	1.68	Yes	No	0	7	8
284	R:R:M283	R:R:P279	1.68	Yes	No	0	5	9
285	R:R:K256	R:R:P255	1.67	No	No	0	5	5
286	R:R:L390	R:R:P391	1.64	No	No	0	7	9
287	R:R:L423	R:R:P391	1.64	No	No	0	8	9
288	L:L:P8	R:R:D207	1.61	No	No	0	0	5
289	R:R:T182	R:R:V181	1.59	No	No	0	8	7
290	R:R:T275	R:R:V271	1.59	No	No	0	4	5
291	R:R:A402	R:R:L398	1.58	No	No	12	3	5
292	R:R:A402	R:R:L404	1.58	No	Yes	12	3	5
293	R:R:I259	R:R:V181	1.54	No	No	0	4	7
294	R:R:I222	R:R:V226	1.54	No	No	0	6	5
295	R:R:I320	R:R:V324	1.54	No	No	0	5	5
296	R:R:I339	R:R:V338	1.54	No	No	0	5	5
297	R:R:I434	R:R:V381	1.54	No	No	0	9	8
298	R:R:I433	R:R:V430	1.54	No	No	0	7	6
299	R:R:I265	R:R:T261	1.52	No	No	0	6	6
300	R:R:M377	R:R:V381	1.52	No	No	0	8	8
301	R:R:L296	R:R:S303	1.5	No	No	0	3	3
302	R:R:L334	R:R:V338	1.49	No	No	0	7	5
303	R:R:L384	R:R:V430	1.49	No	No	0	7	6
304	R:R:L194	R:R:T166	1.47	No	No	0	8	4
305	R:R:L257	R:R:T261	1.47	No	No	0	6	6
306	R:R:I268	R:R:I269	1.47	No	No	0	4	8
307	R:R:N133	R:R:T135	1.46	No	No	0	6	4
308	R:R:Q299	R:R:S298	1.44	No	No	0	1	2
309	R:R:K370	R:R:K371	1.44	No	No	0	7	7
310	R:R:K370	R:R:K373	1.44	No	No	0	7	7
311	R:R:I157	R:R:L156	1.43	Yes	No	0	7	4
312	R:R:I229	R:R:L225	1.43	No	No	0	7	6
313	R:R:Q372	R:R:V367	1.43	No	No	0	5	4
314	R:R:I386	R:R:L387	1.43	No	No	0	6	6
315	R:R:K221	R:R:L284	1.41	No	No	0	7	5
316	R:R:P252	R:R:Y251	1.39	No	No	0	8	6
317	R:R:L379	R:R:L383	1.38	No	No	0	5	6
318	R:R:N138	R:R:N297	1.36	No	No	0	3	2
319	R:R:F349	R:R:V367	1.31	No	No	0	4	4
320	R:R:H177	R:R:N175	1.28	No	No	0	5	7
321	R:R:N138	R:R:Y139	1.16	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F4	6.826	5	4	0
2	L:L:F6	6.702	5	4	0
3	L:L:R10	6.388	5	2	0
4	L:L:F11	5.6525	4	0	0
5	L:L:?12	4.558	5	1	0
6	R:R:I134	4.88	4	3	3
7	R:R:F150	5.655	4	0	5
8	R:R:Y154	3.89	4	0	7
9	R:R:I157	5.7075	4	0	7
10	R:R:N165	5.976	5	0	9
11	R:R:F185	3.674	5	0	8
12	R:R:L189	7.1175	4	9	9
13	R:R:D193	6.434	5	9	9
14	R:R:M201	4.248	5	0	7
15	R:R:W213	8.442	5	1	7
16	R:R:F215	8.9875	4	0	7
17	R:R:C220	6.44	4	1	9
18	R:R:Q227	4.115	4	0	7
19	R:R:F246	7.1825	4	0	8
20	R:R:I266	3.975	4	0	8
21	R:R:M277	4.242	5	0	8
22	R:R:M283	4.56	5	2	5
23	R:R:E289	4.35	4	5	3
24	R:R:K290	5.1875	4	3	3
25	R:R:Y292	6.066	5	4	1
26	R:R:R293	4.835	4	3	4
27	R:R:W307	10.5575	4	0	4
28	R:R:C308	5.8525	4	1	9
29	R:R:E310	9.2275	4	2	5
30	R:R:W312	10.05	5	2	5
31	R:R:R318	11.135	4	0	4
32	R:R:Y341	8.335	4	0	9
33	R:R:I344	4.0725	4	0	9
34	R:R:W389	7.4625	4	0	8
35	R:R:W393	7.01833	6	6	7
36	R:R:L404	5.77	4	12	5
37	R:R:Q410	4.67	4	4	1
38	R:R:I414	6.64	4	4	4
39	R:R:Y417	4.846	5	0	5
40	R:R:H421	5.898	5	1	6
41	R:R:W422	8.06	4	0	6
42	R:R:F442	3.875	6	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F4	R:R:W307	16.8766	7.02	Yes	Yes	0	0	4
2	L:L:F4	L:L:F6	35.2245	5.36	Yes	Yes	4	0	0
3	L:L:L5	R:R:L409	10.4779	4.15	No	No	0	0	4
4	L:L:L5	R:R:Q410	12.4496	5.32	No	Yes	0	0	1
5	L:L:F6	R:R:L141	23.2159	7.31	Yes	No	0	0	4
6	L:L:F6	R:R:I414	23.3855	8.79	Yes	Yes	4	0	4
7	R:R:H421	R:R:Y417	10.6857	3.27	Yes	Yes	0	6	5
8	R:R:H421	R:R:Y154	80.9524	3.27	Yes	Yes	0	6	7
9	R:R:P418	R:R:Y154	75.3212	2.78	No	Yes	0	5	7
10	R:R:F150	R:R:P418	74.4731	8.67	Yes	No	0	5	5
11	R:R:F150	R:R:H142	69.2066	6.79	Yes	No	0	5	5
12	R:R:H142	R:R:L141	24.259	3.86	No	No	0	5	4
13	R:R:H142	R:R:I414	44.036	3.98	No	Yes	0	5	4
14	L:L:?12	R:R:H421	45.007	9.55	Yes	Yes	1	0	6
15	L:L:?12	L:L:Q9	38.2224	3.29	Yes	No	1	0	0
16	L:L:Q9	R:R:W213	21.3332	4.38	No	Yes	1	0	7
17	L:L:Q9	R:R:C220	15.808	4.58	No	Yes	1	0	9
18	L:L:?12	L:L:F11	76.8053	3.01	Yes	Yes	0	0	0
19	L:L:F11	L:L:R10	48.8487	6.41	Yes	Yes	0	0	0
20	L:L:R10	R:R:E310	21.8971	8.14	Yes	Yes	2	0	5
21	L:L:R10	R:R:Y321	22.0455	7.2	Yes	No	2	0	8
22	L:L:F11	R:R:W393	36.0429	4.01	Yes	Yes	0	0	7
23	L:L:?12	R:R:Q227	51.8721	3.29	Yes	Yes	0	0	7
24	R:R:L205	R:R:Y154	13.7938	4.69	No	Yes	0	6	7
25	R:R:I209	R:R:L205	11.309	5.71	No	No	7	5	6
26	R:R:I209	R:R:I210	10.3125	2.94	No	No	0	5	6
27	R:R:W422	R:R:Y154	11.9196	4.82	Yes	Yes	0	6	7
28	R:R:F425	R:R:H421	51.5244	7.92	No	Yes	0	7	6
29	R:R:F425	R:R:M201	15.4391	6.22	No	Yes	0	7	7
30	R:R:C200	R:R:F425	50.9138	4.19	No	No	0	7	7
31	R:R:C200	R:R:V196	100	3.42	No	No	0	7	8
32	R:R:S428	R:R:V196	98.5116	3.23	No	No	0	9	8
33	R:R:D193	R:R:S428	97.9986	7.36	Yes	No	0	9	9
34	R:R:D193	R:R:N165	41.2755	5.39	Yes	Yes	0	9	9
35	R:R:A190	R:R:N165	26.1163	3.13	No	Yes	0	9	9
36	R:R:A190	R:R:C169	23.6569	1.81	No	No	0	9	7
37	R:R:C169	R:R:L187	21.1635	3.17	No	No	0	7	6
38	R:R:L187	R:R:V172	18.5769	5.96	No	No	10	6	8
39	R:R:F442	R:R:V172	17.36	2.62	Yes	No	0	9	8
40	R:R:D193	R:R:L189	70.2879	8.14	Yes	Yes	9	9	9
41	R:R:L189	R:R:T237	68.8717	11.79	Yes	No	0	9	8
42	R:R:N188	R:R:T237	68.0151	8.77	No	No	0	9	8
43	R:R:I266	R:R:N188	66.7769	2.83	Yes	No	0	8	9
44	R:R:F185	R:R:I266	63.1641	2.51	Yes	Yes	0	8	8
45	R:R:F185	R:R:I241	47.3349	3.77	Yes	No	0	8	9
46	R:R:F185	R:R:I265	10.7238	3.77	Yes	No	0	8	6
47	R:R:C308	R:R:W213	13.0136	7.84	Yes	Yes	1	9	7
48	R:R:C220	R:R:C308	12.2503	7.28	Yes	Yes	1	9	9
49	R:R:C308	R:R:V286	22.741	5.12	Yes	No	0	9	5
50	R:R:L325	R:R:Y321	21.7487	12.89	No	No	0	5	8
51	R:R:L325	R:R:M277	20.3579	2.83	No	Yes	0	5	8
52	R:R:I241	R:R:R245	39.838	3.76	No	No	0	9	9
53	R:R:R245	R:R:Y341	38.7695	9.26	No	Yes	0	9	9
54	R:R:L378	R:R:Y341	35.4153	15.24	No	Yes	0	8	9
55	R:R:I344	R:R:L378	33.1595	2.85	Yes	No	0	9	8
56	R:R:F246	R:R:I344	16.0243	3.77	Yes	Yes	0	8	9
57	R:R:E310	R:R:M283	10.1175	6.77	Yes	Yes	2	5	5
58	R:R:E310	R:R:W312	11.5549	15.27	Yes	Yes	2	5	5
59	R:R:V286	R:R:Y306	15.2356	3.79	No	No	0	5	5
60	R:R:P304	R:R:Y306	10.1726	2.78	No	No	11	4	5
61	R:R:W389	R:R:W393	22.7028	6.56	Yes	Yes	0	8	7
62	R:R:F385	R:R:W389	12.3436	6.01	No	Yes	0	9	8
63	R:R:F385	R:R:L334	10.8298	2.44	No	No	0	9	7
64	R:R:G345	R:R:I344	16.0073	3.53	No	Yes	0	6	9
65	R:R:G345	R:R:L348	13.4207	1.71	No	No	0	6	9
66	R:R:K371	R:R:L348	12.1104	4.23	No	No	0	7	9
67	R:R:I414	R:R:Q410	17.6059	4.12	Yes	Yes	4	4	1
68	R:R:C200	R:R:Q227	50.07	6.1	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q2	R:R:Q287	12.8	5	No	No	0	2	0	1
L:L:Q2	R:R:E289	6.37	5	No	Yes	0	3	0	1
L:L:F4	R:R:G212	3.01	4	Yes	No	0	5	0	1
L:L:F4	R:R:Y292	8.25	4	Yes	Yes	0	1	0	1
L:L:F4	R:R:V305	10.49	4	Yes	No	0	4	0	1
L:L:F4	R:R:W307	7.02	4	Yes	Yes	0	4	0	1
L:L:L5	R:R:L409	4.15	0	No	No	0	4	0	1
L:L:L5	R:R:Q410	5.32	0	No	Yes	0	1	0	1
L:L:F6	R:R:L141	7.31	4	Yes	No	0	4	0	1
L:L:F6	R:R:Y292	6.19	4	Yes	Yes	0	1	0	1
L:L:F6	R:R:Q410	5.86	4	Yes	Yes	0	1	0	1
L:L:F6	R:R:I414	8.79	4	Yes	Yes	0	4	0	1
L:L:Q7	R:R:W307	9.86	0	No	Yes	0	4	0	1
L:L:P8	R:R:Y417	5.56	0	No	Yes	0	5	0	1
L:L:Q9	R:R:W213	4.38	1	No	Yes	0	7	0	1
L:L:Q9	R:R:C220	4.58	1	No	Yes	0	9	0	1
L:L:R10	R:R:E310	8.14	2	Yes	Yes	0	5	0	1
L:L:R10	R:R:Y321	7.2	2	Yes	No	0	8	0	1
L:L:R10	R:R:T322	6.47	2	Yes	No	0	6	0	1
L:L:R10	R:R:M396	3.72	2	Yes	No	0	6	0	1
L:L:F11	R:R:V231	9.18	0	Yes	No	0	7	0	1
L:L:F11	R:R:W393	4.01	0	Yes	Yes	0	7	0	1
L:L:?12	R:R:T204	3.65	1	Yes	No	0	6	0	1
L:L:?12	R:R:Q227	3.29	1	Yes	Yes	0	7	0	1
L:L:?12	R:R:H421	9.55	1	Yes	Yes	0	6	0	1
R:R:T135	R:R:Y292	9.99	0	No	Yes	4	1	2	1
R:R:H142	R:R:L141	3.86	0	No	No	5	4	2	1
R:R:H142	R:R:I414	3.98	0	No	Yes	5	4	2	1
R:R:H421	R:R:Y154	3.27	1	Yes	Yes	6	7	1	2
R:R:C200	R:R:Q227	6.1	0	No	Yes	7	7	2	1
R:R:C200	R:R:F425	4.19	0	No	No	7	7	2	2
R:R:N208	R:R:T204	2.92	0	No	No	5	6	2	1
R:R:H421	R:R:T204	5.48	1	Yes	No	6	6	1	1
R:R:F215	R:R:W213	18.04	0	Yes	Yes	7	7	2	1
R:R:G216	R:R:W213	2.81	0	No	Yes	8	7	2	1
R:R:C220	R:R:W213	9.14	1	Yes	Yes	9	7	1	1
R:R:C308	R:R:W213	7.84	1	Yes	Yes	9	7	2	1
R:R:C220	R:R:L284	4.76	1	Yes	No	9	5	1	2
R:R:C220	R:R:C308	7.28	1	Yes	Yes	9	9	1	2
R:R:Q227	R:R:S223	4.33	0	Yes	No	7	5	1	2
R:R:E310	R:R:M283	6.77	2	Yes	Yes	5	5	1	2
R:R:M283	R:R:W312	6.98	2	Yes	Yes	5	5	2	2
R:R:C308	R:R:L284	3.17	1	Yes	No	9	5	2	2
R:R:E289	R:R:Q287	3.82	5	Yes	No	3	2	1	1
R:R:Q287	R:R:R309	5.84	5	No	No	2	4	1	2
R:R:E289	R:R:V305	2.85	5	Yes	No	3	4	1	1
R:R:E289	R:R:W307	4.36	5	Yes	Yes	3	4	1	1
R:R:Q410	R:R:Y292	3.38	4	Yes	Yes	1	1	1	1
R:R:R309	R:R:W307	20.99	0	No	Yes	4	4	2	1
R:R:E310	R:R:W312	15.27	2	Yes	Yes	5	5	1	2
R:R:E310	R:R:Y321	6.73	2	Yes	No	5	8	1	1
R:R:L325	R:R:Y321	12.89	0	No	No	5	8	2	1
R:R:D400	R:R:T322	8.67	0	No	No	5	6	2	1
R:R:F326	R:R:Y330	7.22	6	No	No	6	8	2	2
R:R:F326	R:R:W393	9.02	6	No	Yes	6	7	2	1
R:R:I329	R:R:W393	8.22	0	No	Yes	6	7	2	1
R:R:W393	R:R:Y330	9.65	6	Yes	No	7	8	1	2
R:R:W389	R:R:W393	6.56	0	Yes	Yes	8	7	2	1
R:R:L392	R:R:M396	4.24	0	No	No	6	6	2	1
R:R:M396	R:R:W393	4.65	0	No	Yes	6	7	1	1
R:R:L395	R:R:Y417	8.21	0	No	Yes	6	5	2	1
R:R:I414	R:R:Q410	4.12	4	Yes	Yes	4	1	1	1
R:R:N413	R:R:Y417	4.65	0	No	Yes	5	5	2	1
R:R:I414	R:R:Y415	9.67	4	Yes	No	4	3	1	2
R:R:H421	R:R:Y417	3.27	1	Yes	Yes	6	5	1	1
R:R:F425	R:R:H421	7.92	0	No	Yes	7	6	2	1
R:R:L404	R:R:L409	2.77	12	Yes	No	5	4	2	1
R:R:I203	R:R:Q227	2.74	0	No	Yes	6	7	2	1
R:R:S399	R:R:Y417	2.54	0	No	Yes	4	5	2	1
R:R:V137	R:R:Y292	2.52	0	No	Yes	2	1	2	1
R:R:A211	R:R:G212	1.95	0	No	No	4	5	2	1
L:L:P8	R:R:D207	1.61	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JFY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.78
Number of Linked Nodes	289
Number of Links	321
Number of Hubs	42
Number of Links mediated by Hubs	151
Number of Communities	13
Number of Nodes involved in Communities	52
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	53220
Length Of Smallest Path	3
Average Path Length	14.7208
Length of Longest Path	34
Minimum Path Strength	1.26
Average Path Strength	5.48912
Maximum Path Strength	15.63
Minimum Path Correlation	0.7
Average Path Correlation	0.939797
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	55.2439
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6199
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Neuropeptide-SF
UniProt	O15130
Sequence	>9JFY_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	Q9Y5X5
Sequence	>9JFY_nogp_Chain_R I N I T Y V N Y Y L H Q P Q V A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N K H M H T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G W P F G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y P F K P K L T I K T A F V I I M I I W V L A I T I M S P S A V M L H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A D L S P N E L Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JFY	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-SF	-	Gi1/β1/γ2	3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JFY (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-SF	-		3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JG0	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	-	-	-	2.91	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-FF	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide-VF	-		3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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