psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q2	R:R:Q287	12.8	No	No	5	0	2
2	L:L:Q2	R:R:E289	6.37	No	Yes	5	0	3
3	L:L:F4	L:L:F6	5.36	Yes	Yes	4	0	0
4	L:L:F4	R:R:G212	3.01	Yes	No	0	0	5
5	L:L:F4	R:R:Y292	8.25	Yes	Yes	4	0	1
6	L:L:F4	R:R:V305	10.49	Yes	No	0	0	4
7	L:L:F4	R:R:W307	7.02	Yes	Yes	0	0	4
8	L:L:L5	L:L:Q7	6.65	No	No	0	0	0
9	L:L:L5	R:R:L409	4.15	No	No	0	0	4
10	L:L:L5	R:R:Q410	5.32	No	Yes	0	0	1
11	L:L:F6	R:R:L141	7.31	Yes	No	0	0	4
12	L:L:F6	R:R:Y292	6.19	Yes	Yes	4	0	1
13	L:L:F6	R:R:Q410	5.86	Yes	Yes	4	0	1
14	L:L:F6	R:R:I414	8.79	Yes	Yes	4	0	4
15	L:L:Q7	R:R:W307	9.86	No	Yes	0	0	4
16	L:L:P8	R:R:Y417	5.56	No	Yes	0	0	5
17	L:L:?12	L:L:Q9	3.29	Yes	No	1	0	0
18	L:L:Q9	R:R:W213	4.38	No	Yes	1	0	7
19	L:L:Q9	R:R:C220	4.58	No	Yes	1	0	9
20	L:L:F11	L:L:R10	6.41	Yes	Yes	0	0	0
21	L:L:R10	R:R:E310	8.14	Yes	Yes	2	0	5
22	L:L:R10	R:R:Y321	7.2	Yes	No	2	0	8
23	L:L:R10	R:R:T322	6.47	Yes	No	0	0	6
24	L:L:R10	R:R:M396	3.72	Yes	No	0	0	6
25	L:L:?12	L:L:F11	3.01	Yes	Yes	0	0	0
26	L:L:F11	R:R:V231	9.18	Yes	No	0	0	7
27	L:L:F11	R:R:W393	4.01	Yes	Yes	0	0	7
28	L:L:?12	R:R:T204	3.65	Yes	No	1	0	6
29	L:L:?12	R:R:Q227	3.29	Yes	Yes	0	0	7
30	L:L:?12	R:R:H421	9.55	Yes	Yes	1	0	6
31	R:R:I132	R:R:I134	2.94	No	Yes	3	1	3
32	R:R:I132	R:R:K290	2.91	No	Yes	3	1	3
33	R:R:I132	R:R:Y291	7.25	No	No	3	1	2
34	R:R:I134	R:R:Y136	8.46	Yes	No	3	3	4
35	R:R:I134	R:R:K290	4.36	Yes	Yes	3	3	3
36	R:R:I134	R:R:R293	3.76	Yes	Yes	3	3	4
37	R:R:T135	R:R:Y292	9.99	No	Yes	0	4	1
38	R:R:R293	R:R:Y136	3.09	Yes	No	3	4	4
39	R:R:R295	R:R:Y136	6.17	No	No	0	4	4
40	R:R:Y139	R:R:Y140	9.93	No	No	0	4	5
41	R:R:I210	R:R:Y140	3.63	No	No	0	6	5
42	R:R:H142	R:R:L141	3.86	No	No	0	5	4
43	R:R:F150	R:R:H142	6.79	Yes	No	0	5	5
44	R:R:H142	R:R:I414	3.98	No	Yes	0	5	4
45	R:R:P144	R:R:Q143	3.16	No	No	0	3	6
46	R:R:Q143	R:R:V146	2.87	No	No	0	6	6
47	R:R:I149	R:R:V146	3.07	No	No	0	5	6
48	R:R:F150	R:R:I149	5.02	Yes	No	0	5	5
49	R:R:F150	R:R:P418	8.67	Yes	No	0	5	5
50	R:R:I151	R:R:L205	2.85	No	No	7	6	6
51	R:R:I151	R:R:I209	2.94	No	No	7	6	5
52	R:R:S153	R:R:W422	11.12	No	Yes	0	5	6
53	R:R:L205	R:R:Y154	4.69	No	Yes	0	6	7
54	R:R:P418	R:R:Y154	2.78	No	Yes	0	5	7
55	R:R:H421	R:R:Y154	3.27	Yes	Yes	0	6	7
56	R:R:W422	R:R:Y154	4.82	Yes	Yes	0	6	7
57	R:R:I157	R:R:M201	4.37	Yes	Yes	0	7	7
58	R:R:I157	R:R:W422	11.74	Yes	Yes	0	7	6
59	R:R:G426	R:R:I157	5.29	No	Yes	0	6	7
60	R:R:F158	R:R:M162	3.73	No	No	0	6	6
61	R:R:F158	R:R:M201	3.73	No	Yes	0	6	7
62	R:R:F159	R:R:M162	3.73	No	No	8	4	6
63	R:R:F159	R:R:M163	4.98	No	No	8	4	5
64	R:R:L160	R:R:S429	6.01	No	No	0	6	7
65	R:R:C161	R:R:N165	4.72	No	Yes	0	8	9
66	R:R:C161	R:R:S429	5.16	No	No	0	8	7
67	R:R:M162	R:R:M163	2.89	No	No	8	6	5
68	R:R:G164	R:R:P432	4.06	No	No	0	8	9
69	R:R:A190	R:R:N165	3.13	No	Yes	0	9	9
70	R:R:D193	R:R:N165	5.39	Yes	Yes	0	9	9
71	R:R:L194	R:R:N165	6.87	No	Yes	0	8	9
72	R:R:N165	R:R:P432	9.77	Yes	No	0	9	9
73	R:R:A190	R:R:V168	3.39	No	No	0	9	9
74	R:R:C169	R:R:L187	3.17	No	No	0	7	6
75	R:R:C169	R:R:I191	3.27	No	No	0	7	7
76	R:R:I171	R:R:R174	5.01	No	No	0	8	6
77	R:R:F442	R:R:I171	5.02	Yes	No	0	9	8
78	R:R:M173	R:R:V172	3.04	No	No	10	4	8
79	R:R:L187	R:R:V172	5.96	No	No	10	6	8
80	R:R:L187	R:R:M173	2.83	No	No	10	6	4
81	R:R:M178	R:R:N175	16.83	No	No	0	8	7
82	R:R:M178	R:R:N183	5.61	No	No	0	8	9
83	R:R:N183	R:R:T180	8.77	No	No	0	9	8
84	R:R:A262	R:R:V181	3.39	No	No	0	8	7
85	R:R:D244	R:R:T182	7.23	No	No	0	9	8
86	R:R:I266	R:R:L184	4.28	Yes	No	0	8	5
87	R:R:A240	R:R:F185	5.55	No	Yes	0	7	8
88	R:R:F185	R:R:I241	3.77	Yes	No	0	8	9
89	R:R:F185	R:R:I265	3.77	Yes	No	0	8	6
90	R:R:F442	R:R:I186	3.77	Yes	No	0	9	8
91	R:R:N188	R:R:T237	8.77	No	No	0	9	8
92	R:R:I266	R:R:N188	2.83	Yes	No	0	8	9
93	R:R:N188	R:R:W270	4.52	No	No	0	9	9
94	R:R:D193	R:R:L189	8.14	Yes	Yes	9	9	9
95	R:R:L189	R:R:S234	3	Yes	No	9	9	9
96	R:R:L189	R:R:T237	11.79	Yes	No	0	9	8
97	R:R:L189	R:R:L238	5.54	Yes	No	0	9	9
98	R:R:A233	R:R:S192	3.42	No	No	0	8	9
99	R:R:S192	R:R:S234	4.89	No	No	0	9	9
100	R:R:D193	R:R:S234	5.89	Yes	No	9	9	9
101	R:R:D193	R:R:S428	7.36	Yes	No	0	9	9
102	R:R:D193	R:R:N431	5.39	Yes	No	0	9	9
103	R:R:I198	R:R:L194	4.28	No	No	0	5	8
104	R:R:L195	R:R:S230	4.5	No	No	0	7	7
105	R:R:C200	R:R:V196	3.42	No	No	0	7	8
106	R:R:S230	R:R:V196	3.23	No	No	0	7	8
107	R:R:S428	R:R:V196	3.23	No	No	0	9	8
108	R:R:G197	R:R:M201	5.24	No	Yes	0	7	7
109	R:R:F199	R:R:I198	5.02	No	No	0	6	5
110	R:R:F199	R:R:V226	7.87	No	No	0	6	5
111	R:R:C200	R:R:Q227	6.1	No	Yes	0	7	7
112	R:R:C200	R:R:F425	4.19	No	No	0	7	7
113	R:R:F425	R:R:M201	6.22	No	Yes	0	7	7
114	R:R:N208	R:R:T204	2.92	No	No	0	5	6
115	R:R:H421	R:R:T204	5.48	Yes	No	1	6	6
116	R:R:I209	R:R:L205	5.71	No	No	7	5	6
117	R:R:F215	R:R:L206	4.87	Yes	No	0	7	4
118	R:R:I209	R:R:I210	2.94	No	No	0	5	6
119	R:R:I210	R:R:P214	3.39	No	No	0	6	3
120	R:R:F215	R:R:W213	18.04	Yes	Yes	0	7	7
121	R:R:G216	R:R:W213	2.81	No	Yes	0	8	7
122	R:R:C220	R:R:W213	9.14	Yes	Yes	1	9	7
123	R:R:C308	R:R:W213	7.84	Yes	Yes	1	9	7
124	R:R:F215	R:R:P214	4.33	Yes	No	0	7	3
125	R:R:F215	R:R:M219	8.71	Yes	No	0	7	6
126	R:R:N217	R:R:T218	4.39	No	No	0	3	2
127	R:R:N217	R:R:V286	2.96	No	No	0	3	5
128	R:R:C220	R:R:L284	4.76	Yes	No	1	9	5
129	R:R:C220	R:R:C308	7.28	Yes	Yes	1	9	9
130	R:R:G224	R:R:S223	3.71	No	No	0	4	5
131	R:R:Q227	R:R:S223	4.33	Yes	No	0	7	5
132	R:R:A281	R:R:L225	4.73	No	No	0	5	6
133	R:R:G228	R:R:M277	3.49	No	Yes	0	6	8
134	R:R:I229	R:R:I274	5.89	No	No	0	7	4
135	R:R:I229	R:R:M277	2.92	No	Yes	0	7	8
136	R:R:A232	R:R:F236	4.16	No	No	0	6	6
137	R:R:A232	R:R:M277	3.22	No	Yes	0	6	8
138	R:R:A233	R:R:W270	7.78	No	No	0	8	9
139	R:R:I329	R:R:V235	4.61	No	No	0	6	8
140	R:R:P333	R:R:V235	3.53	No	No	0	9	8
141	R:R:F236	R:R:I269	5.02	No	No	0	6	8
142	R:R:F236	R:R:N328	4.83	No	No	0	6	4
143	R:R:P333	R:R:V239	3.53	No	No	0	9	7
144	R:R:L336	R:R:V239	2.98	No	No	0	7	7
145	R:R:I241	R:R:R245	3.76	No	No	0	9	9
146	R:R:A242	R:R:Y341	4	No	Yes	0	8	9
147	R:R:M340	R:R:V243	4.56	No	No	0	7	7
148	R:R:R245	R:R:Y341	9.26	No	Yes	0	9	9
149	R:R:F246	R:R:V250	11.8	Yes	No	0	8	7
150	R:R:F246	R:R:M340	9.95	Yes	No	0	8	7
151	R:R:F246	R:R:R343	3.21	Yes	No	0	8	6
152	R:R:F246	R:R:I344	3.77	Yes	Yes	0	8	9
153	R:R:I344	R:R:V249	6.14	Yes	No	0	9	9
154	R:R:S347	R:R:V250	4.85	No	No	0	5	7
155	R:R:F253	R:R:P252	8.67	No	No	0	6	8
156	R:R:K254	R:R:P255	3.35	No	No	0	5	5
157	R:R:K256	R:R:T258	3	No	No	0	5	8
158	R:R:K260	R:R:T258	3	No	No	0	5	8
159	R:R:T258	R:R:T261	6.28	No	No	0	8	6
160	R:R:F263	R:R:I266	6.28	No	Yes	0	4	8
161	R:R:F263	R:R:M267	11.2	No	No	0	4	4
162	R:R:I276	R:R:L272	2.85	No	No	0	5	4
163	R:R:I276	R:R:M277	8.75	No	Yes	0	5	8
164	R:R:I276	R:R:N328	8.5	No	No	0	5	4
165	R:R:L325	R:R:M277	2.83	No	Yes	0	5	8
166	R:R:M283	R:R:V282	3.04	Yes	No	0	5	5
167	R:R:E310	R:R:M283	6.77	Yes	Yes	2	5	5
168	R:R:M283	R:R:W312	6.98	Yes	Yes	2	5	5
169	R:R:M283	R:R:M317	4.33	Yes	No	2	5	4
170	R:R:C308	R:R:L284	3.17	Yes	No	1	9	5
171	R:R:V286	R:R:Y306	3.79	No	No	0	5	5
172	R:R:C308	R:R:V286	5.12	Yes	No	0	9	5
173	R:R:E289	R:R:Q287	3.82	Yes	No	5	3	2
174	R:R:Q287	R:R:R309	5.84	No	No	0	2	4
175	R:R:E288	R:R:P304	11	No	No	11	3	4
176	R:R:E288	R:R:Y306	12.35	No	No	11	3	5
177	R:R:E289	R:R:V305	2.85	Yes	No	0	3	4
178	R:R:E289	R:R:W307	4.36	Yes	Yes	0	3	4
179	R:R:K290	R:R:Y291	3.58	Yes	No	3	3	2
180	R:R:K290	R:R:R293	9.9	Yes	Yes	3	3	4
181	R:R:Q410	R:R:Y292	3.38	Yes	Yes	4	1	1
182	R:R:K301	R:R:L296	9.87	No	No	0	1	3
183	R:R:N297	R:R:S298	4.47	No	No	0	2	2
184	R:R:N300	R:R:T302	4.39	No	No	0	3	3
185	R:R:P304	R:R:S303	5.34	No	No	0	4	3
186	R:R:P304	R:R:Y306	2.78	No	No	11	4	5
187	R:R:R309	R:R:W307	20.99	No	Yes	0	4	4
188	R:R:D311	R:R:R309	3.57	No	No	0	4	4
189	R:R:E310	R:R:W312	15.27	Yes	Yes	2	5	5
190	R:R:E310	R:R:Y321	6.73	Yes	No	2	5	8
191	R:R:M317	R:R:W312	9.31	No	Yes	2	4	5
192	R:R:R318	R:R:W312	15.99	Yes	Yes	0	4	5
193	R:R:E316	R:R:N314	15.77	No	No	0	1	4
194	R:R:Q315	R:R:R318	14.02	No	Yes	0	2	4
195	R:R:K319	R:R:R318	6.19	No	Yes	0	4	4
196	R:R:D400	R:R:R318	8.34	No	Yes	0	5	4
197	R:R:L325	R:R:Y321	12.89	No	No	0	5	8
198	R:R:D400	R:R:T322	8.67	No	No	0	5	6
199	R:R:M397	R:R:T323	3.01	No	No	0	6	5
200	R:R:F326	R:R:Y330	7.22	No	No	6	6	8
201	R:R:F326	R:R:W393	9.02	No	Yes	6	6	7
202	R:R:I329	R:R:W393	8.22	No	Yes	0	6	7
203	R:R:L390	R:R:Y330	5.86	No	No	0	7	8
204	R:R:W393	R:R:Y330	9.65	Yes	No	6	7	8
205	R:R:I386	R:R:L334	7.14	No	No	0	6	7
206	R:R:I337	R:R:Y341	4.84	No	Yes	0	9	9
207	R:R:L378	R:R:Y341	15.24	No	Yes	0	8	9
208	R:R:R343	R:R:S347	3.95	No	No	0	6	5
209	R:R:G345	R:R:I344	3.53	No	Yes	0	6	9
210	R:R:I344	R:R:L378	2.85	Yes	No	0	9	8
211	R:R:K371	R:R:L348	4.23	No	No	0	7	9
212	R:R:K371	R:R:V367	9.11	No	No	0	7	4
213	R:R:R369	R:R:S368	7.91	No	No	0	5	4
214	R:R:K370	R:R:S368	4.59	No	No	0	7	4
215	R:R:I374	R:R:L378	2.85	No	No	0	8	8
216	R:R:F438	R:R:M377	4.98	No	No	0	7	8
217	R:R:L384	R:R:S388	3	No	No	0	7	9
218	R:R:F385	R:R:W389	6.01	No	Yes	0	9	8
219	R:R:N427	R:R:S388	8.94	No	No	0	9	9
220	R:R:W389	R:R:W393	6.56	Yes	Yes	0	8	7
221	R:R:N427	R:R:W389	14.69	No	Yes	0	9	8
222	R:R:L390	R:R:T394	4.42	No	No	0	7	7
223	R:R:L392	R:R:M396	4.24	No	No	0	6	6
224	R:R:M396	R:R:W393	4.65	No	Yes	0	6	7
225	R:R:I416	R:R:L395	7.14	No	No	0	5	6
226	R:R:L395	R:R:Y417	8.21	No	Yes	0	6	5
227	R:R:L398	R:R:L404	4.15	No	Yes	12	5	5
228	R:R:E408	R:R:L404	14.58	No	Yes	0	3	5
229	R:R:P406	R:R:S405	5.34	No	No	0	2	3
230	R:R:N407	R:R:S405	4.47	No	No	0	1	3
231	R:R:E408	R:R:S405	4.31	No	No	0	3	3
232	R:R:I414	R:R:Q410	4.12	Yes	Yes	4	4	1
233	R:R:I411	R:R:Y415	4.84	No	No	0	2	3
234	R:R:I412	R:R:N413	2.83	No	No	0	4	5
235	R:R:I412	R:R:I416	8.83	No	No	0	4	5
236	R:R:N413	R:R:Y417	4.65	No	Yes	0	5	5
237	R:R:I414	R:R:Y415	9.67	Yes	No	0	4	3
238	R:R:H421	R:R:Y417	3.27	Yes	Yes	0	6	5
239	R:R:F425	R:R:H421	7.92	No	Yes	0	7	6
240	R:R:L423	R:R:W422	4.56	No	Yes	0	8	6
241	R:R:F442	R:R:G436	4.52	Yes	No	0	9	7
242	R:R:F437	R:R:F438	4.29	No	No	0	6	7
243	R:R:E440	R:R:N439	5.26	No	No	13	5	8
244	R:R:N439	R:R:N441	6.81	No	No	13	8	7
245	R:R:F442	R:R:N439	4.83	Yes	No	0	9	8
246	R:R:E440	R:R:N441	6.57	No	No	13	5	7
247	R:R:A262	R:R:F185	2.77	No	Yes	0	8	8
248	R:R:L383	R:R:L387	2.77	No	No	0	6	6
249	R:R:L404	R:R:L409	2.77	Yes	No	0	5	4
250	R:R:I203	R:R:Q227	2.74	No	Yes	0	6	7
251	R:R:E316	R:R:M317	2.71	No	No	0	1	4
252	R:R:K376	R:R:Q372	2.71	No	No	0	7	5
253	R:R:P313	R:R:W312	2.7	No	Yes	0	8	5
254	R:R:H179	R:R:I259	2.65	No	No	0	8	4
255	R:R:F442	R:R:V172	2.62	Yes	No	0	9	8
256	R:R:R293	R:R:T302	2.59	Yes	No	0	4	3
257	R:R:A424	R:R:W389	2.59	No	Yes	0	7	8
258	R:R:S399	R:R:Y417	2.54	No	Yes	0	4	5
259	R:R:V137	R:R:Y292	2.52	No	Yes	0	2	1
260	R:R:V250	R:R:Y251	2.52	No	No	0	7	6
261	R:R:F185	R:R:I266	2.51	Yes	Yes	0	8	8
262	R:R:I346	R:R:R343	2.51	No	No	0	3	6
263	R:R:F442	R:R:M178	2.49	Yes	No	0	9	8
264	R:R:F326	R:R:L331	2.44	No	No	0	6	5
265	R:R:F385	R:R:L334	2.44	No	No	0	9	7
266	R:R:I241	R:R:Y435	2.42	No	No	0	9	9
267	R:R:I434	R:R:Y435	2.42	No	No	0	9	9
268	R:R:M397	R:R:Y401	2.39	No	No	0	6	5
269	R:R:Q247	R:R:Y251	2.25	No	No	0	4	6
270	R:R:F150	R:R:F419	2.14	Yes	No	0	5	5
271	R:R:F155	R:R:F158	2.14	No	No	0	4	6
272	R:R:A211	R:R:G212	1.95	No	No	0	4	5
273	R:R:A332	R:R:P333	1.87	No	No	0	6	9
274	R:R:A420	R:R:P391	1.87	No	No	0	7	9
275	R:R:G224	R:R:S280	1.86	No	No	0	4	6
276	R:R:G164	R:R:V167	1.84	No	No	0	8	6
277	R:R:A190	R:R:C169	1.81	No	No	0	9	7
278	R:R:A232	R:R:A273	1.79	No	No	0	6	8
279	R:R:P279	R:R:S278	1.78	No	No	0	9	5
280	R:R:G345	R:R:I375	1.76	No	No	0	6	7
281	R:R:G345	R:R:L348	1.71	No	No	0	6	9
282	R:R:A211	R:R:V294	1.7	No	No	0	4	3
283	R:R:M201	R:R:P202	1.68	Yes	No	0	7	8
284	R:R:M283	R:R:P279	1.68	Yes	No	0	5	9
285	R:R:K256	R:R:P255	1.67	No	No	0	5	5
286	R:R:L390	R:R:P391	1.64	No	No	0	7	9
287	R:R:L423	R:R:P391	1.64	No	No	0	8	9
288	L:L:P8	R:R:D207	1.61	No	No	0	0	5
289	R:R:T182	R:R:V181	1.59	No	No	0	8	7
290	R:R:T275	R:R:V271	1.59	No	No	0	4	5
291	R:R:A402	R:R:L398	1.58	No	No	12	3	5
292	R:R:A402	R:R:L404	1.58	No	Yes	12	3	5
293	R:R:I259	R:R:V181	1.54	No	No	0	4	7
294	R:R:I222	R:R:V226	1.54	No	No	0	6	5
295	R:R:I320	R:R:V324	1.54	No	No	0	5	5
296	R:R:I339	R:R:V338	1.54	No	No	0	5	5
297	R:R:I434	R:R:V381	1.54	No	No	0	9	8
298	R:R:I433	R:R:V430	1.54	No	No	0	7	6
299	R:R:I265	R:R:T261	1.52	No	No	0	6	6
300	R:R:M377	R:R:V381	1.52	No	No	0	8	8
301	R:R:L296	R:R:S303	1.5	No	No	0	3	3
302	R:R:L334	R:R:V338	1.49	No	No	0	7	5
303	R:R:L384	R:R:V430	1.49	No	No	0	7	6
304	R:R:L194	R:R:T166	1.47	No	No	0	8	4
305	R:R:L257	R:R:T261	1.47	No	No	0	6	6
306	R:R:I268	R:R:I269	1.47	No	No	0	4	8
307	R:R:N133	R:R:T135	1.46	No	No	0	6	4
308	R:R:Q299	R:R:S298	1.44	No	No	0	1	2
309	R:R:K370	R:R:K371	1.44	No	No	0	7	7
310	R:R:K370	R:R:K373	1.44	No	No	0	7	7
311	R:R:I157	R:R:L156	1.43	Yes	No	0	7	4
312	R:R:I229	R:R:L225	1.43	No	No	0	7	6
313	R:R:Q372	R:R:V367	1.43	No	No	0	5	4
314	R:R:I386	R:R:L387	1.43	No	No	0	6	6
315	R:R:K221	R:R:L284	1.41	No	No	0	7	5
316	R:R:P252	R:R:Y251	1.39	No	No	0	8	6
317	R:R:L379	R:R:L383	1.38	No	No	0	5	6
318	R:R:N138	R:R:N297	1.36	No	No	0	3	2
319	R:R:F349	R:R:V367	1.31	No	No	0	4	4
320	R:R:H177	R:R:N175	1.28	No	No	0	5	7
321	R:R:N138	R:R:Y139	1.16	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F4	6.826	5	4	0
2	L:L:F6	6.702	5	4	0
3	L:L:R10	6.388	5	2	0
4	L:L:F11	5.6525	4	0	0
5	L:L:?12	4.558	5	1	0
6	R:R:I134	4.88	4	3	3
7	R:R:F150	5.655	4	0	5
8	R:R:Y154	3.89	4	0	7
9	R:R:I157	5.7075	4	0	7
10	R:R:N165	5.976	5	0	9
11	R:R:F185	3.674	5	0	8
12	R:R:L189	7.1175	4	9	9
13	R:R:D193	6.434	5	9	9
14	R:R:M201	4.248	5	0	7
15	R:R:W213	8.442	5	1	7
16	R:R:F215	8.9875	4	0	7
17	R:R:C220	6.44	4	1	9
18	R:R:Q227	4.115	4	0	7
19	R:R:F246	7.1825	4	0	8
20	R:R:I266	3.975	4	0	8
21	R:R:M277	4.242	5	0	8
22	R:R:M283	4.56	5	2	5
23	R:R:E289	4.35	4	5	3
24	R:R:K290	5.1875	4	3	3
25	R:R:Y292	6.066	5	4	1
26	R:R:R293	4.835	4	3	4
27	R:R:W307	10.5575	4	0	4
28	R:R:C308	5.8525	4	1	9
29	R:R:E310	9.2275	4	2	5
30	R:R:W312	10.05	5	2	5
31	R:R:R318	11.135	4	0	4
32	R:R:Y341	8.335	4	0	9
33	R:R:I344	4.0725	4	0	9
34	R:R:W389	7.4625	4	0	8
35	R:R:W393	7.01833	6	6	7
36	R:R:L404	5.77	4	12	5
37	R:R:Q410	4.67	4	4	1
38	R:R:I414	6.64	4	4	4
39	R:R:Y417	4.846	5	0	5
40	R:R:H421	5.898	5	1	6
41	R:R:W422	8.06	4	0	6
42	R:R:F442	3.875	6	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F4	R:R:W307	16.8766	7.02	Yes	Yes	0	0	4
2	L:L:F4	L:L:F6	35.2245	5.36	Yes	Yes	4	0	0
3	L:L:L5	R:R:L409	10.4779	4.15	No	No	0	0	4
4	L:L:L5	R:R:Q410	12.4496	5.32	No	Yes	0	0	1
5	L:L:F6	R:R:L141	23.2159	7.31	Yes	No	0	0	4
6	L:L:F6	R:R:I414	23.3855	8.79	Yes	Yes	4	0	4
7	R:R:H421	R:R:Y417	10.6857	3.27	Yes	Yes	0	6	5
8	R:R:H421	R:R:Y154	80.9524	3.27	Yes	Yes	0	6	7
9	R:R:P418	R:R:Y154	75.3212	2.78	No	Yes	0	5	7
10	R:R:F150	R:R:P418	74.4731	8.67	Yes	No	0	5	5
11	R:R:F150	R:R:H142	69.2066	6.79	Yes	No	0	5	5
12	R:R:H142	R:R:L141	24.259	3.86	No	No	0	5	4
13	R:R:H142	R:R:I414	44.036	3.98	No	Yes	0	5	4
14	L:L:?12	R:R:H421	45.007	9.55	Yes	Yes	1	0	6
15	L:L:?12	L:L:Q9	38.2224	3.29	Yes	No	1	0	0
16	L:L:Q9	R:R:W213	21.3332	4.38	No	Yes	1	0	7
17	L:L:Q9	R:R:C220	15.808	4.58	No	Yes	1	0	9
18	L:L:?12	L:L:F11	76.8053	3.01	Yes	Yes	0	0	0
19	L:L:F11	L:L:R10	48.8487	6.41	Yes	Yes	0	0	0
20	L:L:R10	R:R:E310	21.8971	8.14	Yes	Yes	2	0	5
21	L:L:R10	R:R:Y321	22.0455	7.2	Yes	No	2	0	8
22	L:L:F11	R:R:W393	36.0429	4.01	Yes	Yes	0	0	7
23	L:L:?12	R:R:Q227	51.8721	3.29	Yes	Yes	0	0	7
24	R:R:L205	R:R:Y154	13.7938	4.69	No	Yes	0	6	7
25	R:R:I209	R:R:L205	11.309	5.71	No	No	7	5	6
26	R:R:I209	R:R:I210	10.3125	2.94	No	No	0	5	6
27	R:R:W422	R:R:Y154	11.9196	4.82	Yes	Yes	0	6	7
28	R:R:F425	R:R:H421	51.5244	7.92	No	Yes	0	7	6
29	R:R:F425	R:R:M201	15.4391	6.22	No	Yes	0	7	7
30	R:R:C200	R:R:F425	50.9138	4.19	No	No	0	7	7
31	R:R:C200	R:R:V196	100	3.42	No	No	0	7	8
32	R:R:S428	R:R:V196	98.5116	3.23	No	No	0	9	8
33	R:R:D193	R:R:S428	97.9986	7.36	Yes	No	0	9	9
34	R:R:D193	R:R:N165	41.2755	5.39	Yes	Yes	0	9	9
35	R:R:A190	R:R:N165	26.1163	3.13	No	Yes	0	9	9
36	R:R:A190	R:R:C169	23.6569	1.81	No	No	0	9	7
37	R:R:C169	R:R:L187	21.1635	3.17	No	No	0	7	6
38	R:R:L187	R:R:V172	18.5769	5.96	No	No	10	6	8
39	R:R:F442	R:R:V172	17.36	2.62	Yes	No	0	9	8
40	R:R:D193	R:R:L189	70.2879	8.14	Yes	Yes	9	9	9
41	R:R:L189	R:R:T237	68.8717	11.79	Yes	No	0	9	8
42	R:R:N188	R:R:T237	68.0151	8.77	No	No	0	9	8
43	R:R:I266	R:R:N188	66.7769	2.83	Yes	No	0	8	9
44	R:R:F185	R:R:I266	63.1641	2.51	Yes	Yes	0	8	8
45	R:R:F185	R:R:I241	47.3349	3.77	Yes	No	0	8	9
46	R:R:F185	R:R:I265	10.7238	3.77	Yes	No	0	8	6
47	R:R:C308	R:R:W213	13.0136	7.84	Yes	Yes	1	9	7
48	R:R:C220	R:R:C308	12.2503	7.28	Yes	Yes	1	9	9
49	R:R:C308	R:R:V286	22.741	5.12	Yes	No	0	9	5
50	R:R:L325	R:R:Y321	21.7487	12.89	No	No	0	5	8
51	R:R:L325	R:R:M277	20.3579	2.83	No	Yes	0	5	8
52	R:R:I241	R:R:R245	39.838	3.76	No	No	0	9	9
53	R:R:R245	R:R:Y341	38.7695	9.26	No	Yes	0	9	9
54	R:R:L378	R:R:Y341	35.4153	15.24	No	Yes	0	8	9
55	R:R:I344	R:R:L378	33.1595	2.85	Yes	No	0	9	8
56	R:R:F246	R:R:I344	16.0243	3.77	Yes	Yes	0	8	9
57	R:R:E310	R:R:M283	10.1175	6.77	Yes	Yes	2	5	5
58	R:R:E310	R:R:W312	11.5549	15.27	Yes	Yes	2	5	5
59	R:R:V286	R:R:Y306	15.2356	3.79	No	No	0	5	5
60	R:R:P304	R:R:Y306	10.1726	2.78	No	No	11	4	5
61	R:R:W389	R:R:W393	22.7028	6.56	Yes	Yes	0	8	7
62	R:R:F385	R:R:W389	12.3436	6.01	No	Yes	0	9	8
63	R:R:F385	R:R:L334	10.8298	2.44	No	No	0	9	7
64	R:R:G345	R:R:I344	16.0073	3.53	No	Yes	0	6	9
65	R:R:G345	R:R:L348	13.4207	1.71	No	No	0	6	9
66	R:R:K371	R:R:L348	12.1104	4.23	No	No	0	7	9
67	R:R:I414	R:R:Q410	17.6059	4.12	Yes	Yes	4	4	1
68	R:R:C200	R:R:Q227	50.07	6.1	No	Yes	0	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q2	R:R:Q287	12.8	5	No	No	0	2	0	1
L:L:Q2	R:R:E289	6.37	5	No	Yes	0	3	0	1
L:L:F4	R:R:G212	3.01	4	Yes	No	0	5	0	1
L:L:F4	R:R:Y292	8.25	4	Yes	Yes	0	1	0	1
L:L:F4	R:R:V305	10.49	4	Yes	No	0	4	0	1
L:L:F4	R:R:W307	7.02	4	Yes	Yes	0	4	0	1
L:L:L5	R:R:L409	4.15	0	No	No	0	4	0	1
L:L:L5	R:R:Q410	5.32	0	No	Yes	0	1	0	1
L:L:F6	R:R:L141	7.31	4	Yes	No	0	4	0	1
L:L:F6	R:R:Y292	6.19	4	Yes	Yes	0	1	0	1
L:L:F6	R:R:Q410	5.86	4	Yes	Yes	0	1	0	1
L:L:F6	R:R:I414	8.79	4	Yes	Yes	0	4	0	1
L:L:Q7	R:R:W307	9.86	0	No	Yes	0	4	0	1
L:L:P8	R:R:Y417	5.56	0	No	Yes	0	5	0	1
L:L:Q9	R:R:W213	4.38	1	No	Yes	0	7	0	1
L:L:Q9	R:R:C220	4.58	1	No	Yes	0	9	0	1
L:L:R10	R:R:E310	8.14	2	Yes	Yes	0	5	0	1
L:L:R10	R:R:Y321	7.2	2	Yes	No	0	8	0	1
L:L:R10	R:R:T322	6.47	2	Yes	No	0	6	0	1
L:L:R10	R:R:M396	3.72	2	Yes	No	0	6	0	1
L:L:F11	R:R:V231	9.18	0	Yes	No	0	7	0	1
L:L:F11	R:R:W393	4.01	0	Yes	Yes	0	7	0	1
L:L:?12	R:R:T204	3.65	1	Yes	No	0	6	0	1
L:L:?12	R:R:Q227	3.29	1	Yes	Yes	0	7	0	1
L:L:?12	R:R:H421	9.55	1	Yes	Yes	0	6	0	1
R:R:T135	R:R:Y292	9.99	0	No	Yes	4	1	2	1
R:R:H142	R:R:L141	3.86	0	No	No	5	4	2	1
R:R:H142	R:R:I414	3.98	0	No	Yes	5	4	2	1
R:R:H421	R:R:Y154	3.27	1	Yes	Yes	6	7	1	2
R:R:C200	R:R:Q227	6.1	0	No	Yes	7	7	2	1
R:R:C200	R:R:F425	4.19	0	No	No	7	7	2	2
R:R:N208	R:R:T204	2.92	0	No	No	5	6	2	1
R:R:H421	R:R:T204	5.48	1	Yes	No	6	6	1	1
R:R:F215	R:R:W213	18.04	0	Yes	Yes	7	7	2	1
R:R:G216	R:R:W213	2.81	0	No	Yes	8	7	2	1
R:R:C220	R:R:W213	9.14	1	Yes	Yes	9	7	1	1
R:R:C308	R:R:W213	7.84	1	Yes	Yes	9	7	2	1
R:R:C220	R:R:L284	4.76	1	Yes	No	9	5	1	2
R:R:C220	R:R:C308	7.28	1	Yes	Yes	9	9	1	2
R:R:Q227	R:R:S223	4.33	0	Yes	No	7	5	1	2
R:R:E310	R:R:M283	6.77	2	Yes	Yes	5	5	1	2
R:R:M283	R:R:W312	6.98	2	Yes	Yes	5	5	2	2
R:R:C308	R:R:L284	3.17	1	Yes	No	9	5	2	2
R:R:E289	R:R:Q287	3.82	5	Yes	No	3	2	1	1
R:R:Q287	R:R:R309	5.84	5	No	No	2	4	1	2
R:R:E289	R:R:V305	2.85	5	Yes	No	3	4	1	1
R:R:E289	R:R:W307	4.36	5	Yes	Yes	3	4	1	1
R:R:Q410	R:R:Y292	3.38	4	Yes	Yes	1	1	1	1
R:R:R309	R:R:W307	20.99	0	No	Yes	4	4	2	1
R:R:E310	R:R:W312	15.27	2	Yes	Yes	5	5	1	2
R:R:E310	R:R:Y321	6.73	2	Yes	No	5	8	1	1
R:R:L325	R:R:Y321	12.89	0	No	No	5	8	2	1
R:R:D400	R:R:T322	8.67	0	No	No	5	6	2	1
R:R:F326	R:R:Y330	7.22	6	No	No	6	8	2	2
R:R:F326	R:R:W393	9.02	6	No	Yes	6	7	2	1
R:R:I329	R:R:W393	8.22	0	No	Yes	6	7	2	1
R:R:W393	R:R:Y330	9.65	6	Yes	No	7	8	1	2
R:R:W389	R:R:W393	6.56	0	Yes	Yes	8	7	2	1
R:R:L392	R:R:M396	4.24	0	No	No	6	6	2	1
R:R:M396	R:R:W393	4.65	0	No	Yes	6	7	1	1
R:R:L395	R:R:Y417	8.21	0	No	Yes	6	5	2	1
R:R:I414	R:R:Q410	4.12	4	Yes	Yes	4	1	1	1
R:R:N413	R:R:Y417	4.65	0	No	Yes	5	5	2	1
R:R:I414	R:R:Y415	9.67	4	Yes	No	4	3	1	2
R:R:H421	R:R:Y417	3.27	1	Yes	Yes	6	5	1	1
R:R:F425	R:R:H421	7.92	0	No	Yes	7	6	2	1
R:R:L404	R:R:L409	2.77	12	Yes	No	5	4	2	1
R:R:I203	R:R:Q227	2.74	0	No	Yes	6	7	2	1
R:R:S399	R:R:Y417	2.54	0	No	Yes	4	5	2	1
R:R:V137	R:R:Y292	2.52	0	No	Yes	2	1	2	1
R:R:A211	R:R:G212	1.95	0	No	No	4	5	2	1
L:L:P8	R:R:D207	1.61	0	No	No	0	5	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JFY_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.78
Number of Linked Nodes	289
Number of Links	321
Number of Hubs	42
Number of Links mediated by Hubs	151
Number of Communities	13
Number of Nodes involved in Communities	52
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	53220
Length Of Smallest Path	3
Average Path Length	14.7208
Length of Longest Path	34
Minimum Path Strength	1.26
Average Path Strength	5.48912
Maximum Path Strength	15.63
Minimum Path Correlation	0.7
Average Path Correlation	0.939797
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	55.2439
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.6199
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • detection of stimulus • response to abiotic stimulus • detection of abiotic stimulus • regulation of signaling • regulation of signal transduction • regulation of MAPK cascade • intracellular signal transduction • regulation of intracellular signal transduction • regulation of response to stimulus • intracellular signaling cassette • MAPK cascade • regulation of cell communication • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to endogenous stimulus • response to chemical • cellular response to hormone stimulus • intracellular organelle • cellular anatomical structure • intracellular anatomical structure • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • actin cytoskeleton • cell periphery • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • nucleolus • intracellular organelle lumen • organelle lumen • nuclear lumen • cell cortex • centrosome • microtubule organizing center • microtubule cytoskeleton • centriolar satellite • nucleoplasm • Golgi apparatus • endomembrane system • ciliary basal body • molecular function activator activity • neuropeptide activity • signaling receptor activator activity • hormone activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • response to xenobiotic stimulus • positive regulation of cytosolic calcium ion concentration • spinal cord development • central nervous system development • nervous system development • response to nutrient levels • regulation of response to nutrient levels • negative regulation of response to food • negative regulation of response to nutrient levels • negative regulation of response to stimulus • negative regulation of appetite • regulation of response to food • response to food • regulation of appetite • defense response • immune response • response to stress • inflammatory response • acute inflammatory response to antigenic stimulus • acute inflammatory response • inflammatory response to antigenic stimulus • multi-multicellular organism process • maternal process involved in female pregnancy • reproductive process • multicellular organismal reproductive process • female pregnancy • multi-organism reproductive process • circulatory system process • regulation of blood pressure • positive regulation of blood pressure • blood circulation • regulation of membrane depolarization • membrane depolarization • regulation of membrane potential • regulation of postsynaptic membrane potential • chemical synaptic transmission, postsynaptic • trans-synaptic signaling • cell surface receptor signaling pathway • chemical synaptic transmission • anterograde trans-synaptic signaling • excitatory postsynaptic potential • somatostatin secretion • heart process • negative regulation of heart rate • regulation of heart contraction • regulation of system process • negative regulation of blood circulation • negative regulation of heart contraction • regulation of blood circulation • regulation of multicellular organismal process • heart contraction • negative regulation of multicellular organismal process • regulation of heart rate • vasopressin secretion • somatodendritic compartment • cell body • perikaryon • neuronal cell body • dense core granule • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal dense core vesicle • dendrite • dendritic tree • axon • axon terminus • presynapse • distal axon • neuron projection terminus • postsynapse
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?12
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y5X5
Sequence	>9JFY_nogp_Chain_R I N I T Y V N Y Y L H Q P Q V A A I F I I S Y F L I F F L C M M G N T V V C F I V M R N K H M H T V T N L F I L N L A I S D L L V G I F C M P I T L L D N I I A G W P F G N T M C K I S G L V Q G I S V A A S V F T L V A I A V D R F Q C V V Y P F K P K L T I K T A F V I I M I I W V L A I T I M S P S A V M L H V Q E E K Y Y R V R L N S Q N K T S P V Y W C R E D W P N Q E M R K I Y T T V L F A N I Y L A P L S L I V I M Y G R I G I S L F R V V S R K K Q K I I K M L L I V A L L F I L S W L P L W T L M M L S D Y A D L S P N E L Q I I N I Y I Y P F A H W L A F G N S S V N P I I Y G F F N E N F R R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9JFY	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-	Gi1/β1/γ2	3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JFY (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	hNPSF	-		3.21	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9JG0	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	-	-	-	2.91	2025-04-09	doi.org/10.1038/s44319-025-00428-2
	9M1O	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-	Gi1/β1/γ2	2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M1O (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Morphine-Modulating Neuropeptide B	-		2.49	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-	Gi1/β1/γ2	3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M54 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF2	Homo sapiens	Neuropeptide VF	-		3.24	2025-07-23	doi.org/10.1016/j.celrep.2025.116160

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