Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.544164
2A:A:H41 6.01416
3A:A:L45 5.2575418
4A:A:L46 5.125428
5A:A:N50 8.91254136
6A:A:S51 3.8625409
7A:A:I56 3.652517
8A:A:M60 6.3419
9A:A:V217 3.4475415
10A:A:F219 6.412518
11A:A:M221 4.40429718
12A:A:F222 8.34833627
13A:A:Q227 4.814529
14A:A:R232 8.42428
15A:A:K233 6.42333629
16A:A:W234 6.92529
17A:A:F238 8.7175429
18A:A:I244 4.316528
19A:A:I245 3.2475417
20A:A:V247 4.4725417
21A:A:D249 11.94254138
22A:A:R265 6.814139
23A:A:F273 6.91789
24A:A:W277 8.6586
25A:A:W281 7.8565195
26A:A:L282 5.6425429
27A:A:I285 2.642527
28A:A:L289 5.2725489
29A:A:F290 4.65429719
30A:A:L291 4.1375408
31A:A:N292 5.0475419
32A:A:L296 5.32406
33A:A:D310 4.25254203
34A:A:F312 4.67408
35A:A:F315 14.6825146
36A:A:Y318 9.1085146
37A:A:E330 3.535403
38A:A:K338 9.2025485
39A:A:Y339 6.086583
40A:A:F340 8.38754147
41A:A:R342 7.1075484
42A:A:F345 7.57488
43A:A:L346 4.504584
44A:A:S349 4.39487
45A:A:Y358 8.31414
46A:A:C359 4.846585
47A:A:Y360 6.504518
48A:A:F363 9.8175485
49A:A:T364 7.3675419
50A:A:N371 5.53167619
51A:A:R373 5.67415
52A:A:F376 3.66667618
53A:A:R380 4.6825417
54A:A:D381 4.775418
55A:A:R385 9.818515
56A:A:H387 6.10254218
57A:A:L388 4.67408
58A:A:Y391 9.0065214
59A:A:L393 2.9175408
60A:A:L394 3.06408
61B:B:R22 5.9875406
62B:B:I37 5.005402
63B:B:V40 4.2575403
64B:B:H54 10.15539
65B:B:I58 5.82409
66B:B:M61 4.715436
67B:B:W63 7.76167637
68B:B:V71 3.954558
69B:B:D76 8.9054169
70B:B:L79 4.178557
71B:B:I81 3.9575457
72B:B:W82 10.0483639
73B:B:Y85 13.41434
74B:B:N88 5.545407
75B:B:K89 6.798509
76B:B:H91 5.502555
77B:B:I93 4.2225407
78B:B:L95 5.128558
79B:B:W99 9.52333629
80B:B:C103 3.4275458
81B:B:Y105 4.91167606
82B:B:N110 6.50254174
83B:B:Y111 5.81754174
84B:B:C114 5.01458
85B:B:N119 3.044529
86B:B:I123 3.9875406
87B:B:Y124 5.62167656
88B:B:L126 4.4525455
89B:B:H142 7.544599
90B:B:Y145 6.55857728
91B:B:F151 5.06509
92B:B:L152 6.46443
93B:B:N155 7.32754233
94B:B:V158 4.028545
95B:B:T159 5.745499
96B:B:S160 4.7975446
97B:B:D163 6.3575499
98B:B:C166 3.796548
99B:B:L168 3.5525446
100B:B:W169 9.14333698
101B:B:D170 6.564239
102B:B:F180 7.154547
103B:B:H183 6.38833649
104B:B:D186 6.956529
105B:B:V187 4.488549
106B:B:L190 5.0275445
107B:B:F199 6.916549
108B:B:V200 5.93466
109B:B:S201 4.6075449
110B:B:A203 4.34448
111B:B:C204 4.225627
112B:B:K209 7.54546
113B:B:L210 5.9075405
114B:B:W211 9.105648
115B:B:Q220 6.895467
116B:B:F222 6.36468
117B:B:H225 7.835669
118B:B:D228 8.815429
119B:B:I232 7.2475468
120B:B:F235 5.663758156
121B:B:F241 7.34833666
122B:B:T243 6.56468
123B:B:T249 7.6475466
124B:B:R251 10.264568
125B:B:F253 6.8775466
126B:B:D254 3.975409
127B:B:R256 8.785409
128B:B:D258 9.1375467
129B:B:Q259 4.525406
130B:B:Y264 4.8785105
131B:B:H266 2.7425404
132B:B:F278 5.118507
133B:B:L284 3.446505
134B:B:L286 4.7854257
135B:B:Y289 7.2685107
136B:B:N295 6.6454106
137B:B:W297 6.78754108
138B:B:D298 4.005409
139B:B:H311 10.6954119
140B:B:V315 3.71407
141B:B:L318 4.434256
142B:B:M325 5.44435
143B:B:V327 4.73406
144B:B:T329 4.575408
145B:B:W332 11.0356199
146B:B:D333 6.74754119
147B:B:L336 3.3675437
148B:B:K337 8.664116
149B:B:W339 8.0656119
150G:G:L19 3.4775409
151G:G:R27 3.805408
152G:G:D48 6.412509
153G:G:P49 4.7625407
154G:G:L51 4.305606
155G:G:N59 6.6025439
156G:G:P60 5.994539
157G:G:F61 6.02625838
158R:R:F45 5.425407
159R:R:L48 3.3625406
160R:R:N56 7.165409
161R:R:N66 7.0154127
162R:R:L69 7.6145128
163R:R:P72 4.2254286
164R:R:Y74 8.466676128
165R:R:F76 3.4485287
166R:R:L80 5.85409
167R:R:D84 7.516509
168R:R:F120 5.195405
169R:R:L135 5.64254308
170R:R:I138 5.7225408
171R:R:Y143 13.24418
172R:R:F147 13.03416
173R:R:L150 5.495417
174R:R:Y152 9.075408
175R:R:W169 4.088336299
176R:R:F179 8.4285313
177R:R:F196 13.34254187
178R:R:M199 4.39407
179R:R:M203 5.064308
180R:R:Y207 4.245409
181R:R:F211 3.6985326
182R:R:F213 6.225415
183R:R:H217 6.736517
184R:R:I244 2.465407
185R:R:W255 7.468577188
186R:R:F259 11.424186
187R:R:H261 9.5925475
188R:R:I266 6.595473
189R:R:Y284 5.648575
190R:R:M289 4.76754266
191R:R:I298 4.424339
192R:R:F301 3.54406
193R:R:L306 3.8625128
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D66 B:B:L69 28.17555.43NoNo085
2B:B:D66 B:B:R68 28.27862.38NoNo085
3R:R:F147 R:R:F213 50.8986.43YesYes165
4R:R:F147 R:R:I146 46.51018.79YesNo069
5A:A:Y391 R:R:I146 89.69593.63YesNo049
6A:A:Q390 A:A:Y391 88.38057.89NoYes044
7A:A:Q390 R:R:M73 88.38774.08NoNo048
8R:R:M73 R:R:Y74 89.06415.99NoYes088
9R:R:L69 R:R:Y74 88.969817.58YesYes1288
10R:R:L69 R:R:N66 99.84776.87YesYes1287
11B:B:D312 R:R:N66 99.97254.04NoYes057
12B:B:D312 B:B:D333 1002.66NoYes059
13B:B:D333 B:B:H311 99.762910.08YesYes1199
14B:B:H311 B:B:T329 99.07045.48YesYes098
15B:B:L318 B:B:T329 98.68324.42YesYes068
16B:B:L286 B:B:L318 98.69215.54YesYes2576
17B:B:L286 B:B:V296 99.3844.47YesNo075
18B:B:L284 B:B:V296 99.29114.47YesNo055
19B:B:L284 B:B:S279 47.54293YesNo059
20B:B:S279 G:G:D48 47.51737.36NoYes099
21G:G:D48 G:G:P49 95.66894.83YesYes097
22B:B:M325 G:G:P49 95.2218.39YesYes057
23B:B:M325 G:G:P60 61.12535.03YesYes359
24B:B:Y85 G:G:P60 37.117912.52YesYes349
25B:B:R68 B:B:Y85 28.893229.84NoYes054
26B:B:L284 G:G:L51 51.67342.77YesYes056
27G:G:D48 G:G:L51 48.49786.79YesYes096
28A:A:W281 B:B:W332 32.57533.75YesYes1959
29B:B:S316 B:B:W332 53.14613.71NoYes099
30B:B:I58 B:B:S316 17.67743.1YesNo099
31B:B:I58 B:B:L336 18.03044.28YesYes097
32A:A:F290 A:A:V247 14.30653.93YesYes197
33A:A:F290 A:A:I288 20.3343.77YesNo099
34A:A:D378 A:A:I288 20.57711.2NoNo079
35A:A:D378 A:A:Y360 42.626713.79NoYes078
36A:A:Y358 A:A:Y360 21.52943.97YesYes148
37A:A:Y358 R:R:I221 21.6298.46YesNo147
38A:A:L394 R:R:I221 43.23892.85YesNo087
39A:A:L388 A:A:L394 43.35412.77YesYes088
40A:A:L388 R:R:I146 43.23069.99YesNo089
41A:A:F290 A:A:H362 20.33443.39YesNo099
42A:A:D378 A:A:H362 21.80895.04NoNo079
43A:A:R385 A:A:Y360 44.93594.12YesYes158
44A:A:R385 R:R:I221 21.571911.27YesNo157
45A:A:D381 A:A:Y360 23.43974.6YesYes188
46A:A:D381 R:R:H217 23.48163.78YesYes187
47R:R:F213 R:R:H217 46.80659.05YesYes157
48A:A:R385 R:R:H217 23.511.28YesYes157
49A:A:D249 A:A:N50 18.513316.16YesYes1386
50A:A:D249 A:A:K293 23.13915.21YesNo089
51A:A:K293 A:A:N292 32.3924.2NoYes099
52A:A:I56 A:A:N292 12.24514.25YesYes179
53A:A:F290 A:A:I56 11.44693.77YesYes197
54A:A:N292 A:A:V247 10.84624.43YesYes197
55A:A:N292 A:A:T364 10.84547.31YesYes199
56A:A:F290 A:A:T364 11.82799.08YesYes199
57A:A:N50 A:A:R265 15.42976.03YesYes1369
58A:A:K233 B:B:Y145 12.58843.58YesYes298
59A:A:K233 A:A:Q236 22.635.42YesNo098
60A:A:Q236 A:A:W281 23.25713.14NoYes085
61B:B:Q75 B:B:W99 12.8128.76NoYes099
62A:A:H357 A:A:W277 47.660921.16NoYes076
63A:A:H357 A:A:S286 48.87532.79NoNo078
64A:A:I382 A:A:S286 49.118110.84NoNo068
65A:A:I382 A:A:Y360 49.36076.04NoYes068
66A:A:S349 A:A:W277 15.64763.71YesYes876
67A:A:C359 A:A:W277 28.06615.22YesYes856
68A:A:L289 A:A:L291 10.69724.15YesYes098
69A:A:C359 A:A:L289 12.42434.76YesYes859
70A:A:R342 A:A:Y339 12.92489.26YesYes843
71A:A:L346 A:A:R342 22.86584.86YesYes844
72A:A:L346 A:A:S349 12.91943YesYes847
73A:A:F363 A:A:K338 13.428419.85YesYes855
74A:A:C359 A:A:L346 12.92343.17YesYes854
75A:A:N264 A:A:R265 12.34444.82NoYes099
76A:A:N264 A:A:Y311 10.80153.49NoNo096
77A:A:E330 A:A:K338 14.92025.4YesYes035
78R:R:L306 R:R:L69 10.81834.15YesYes1288
79R:R:A300 R:R:L306 10.77643.15NoYes088
80B:B:L69 B:B:Y105 24.55955.86NoYes056
81B:B:H62 B:B:Y105 20.06023.27NoYes066
82B:B:H62 B:B:R150 19.953718.05NoNo066
83B:B:C148 B:B:R150 19.8474.18NoNo066
84B:B:C148 B:B:L190 14.93624.76NoYes065
85B:B:I338 B:B:L51 27.92164.28NoNo359
86B:B:S84 B:B:Y85 10.56685.09NoYes354
87B:B:S84 B:B:W63 29.24354.94NoYes357
88B:B:M61 B:B:W63 36.92964.65YesYes367
89B:B:C317 B:B:S316 36.10543.44NoNo079
90G:G:F61 G:G:N59 23.84144.83YesYes389
91B:B:I338 G:G:F61 28.12335.02NoYes358
92B:B:C317 B:B:M61 36.52196.48NoYes076
93B:B:L336 B:B:L51 18.40562.77YesNo379
94B:B:M325 G:G:N59 24.34782.8YesYes359
95G:G:F61 G:G:P60 23.84214.33YesYes389
96B:B:S84 G:G:F61 18.99285.28NoYes358
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3F
Class A
SubFamily Peptide
Type Melanocortin
SubType MC3
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.75
Date 2025-08-06
D.O.I. doi.org/10.1016/j.str.2025.03.004
Net Summary
Imin 2.66
Number of Linked Nodes 847
Number of Links 1050
Number of Hubs 193
Number of Links mediated by Hubs 673
Number of Communities 33
Number of Nodes involved in Communities 263
Number of Links involved in Communities 374
Path Summary
Number Of Nodes in MetaPath 97
Number Of Links MetaPath 96
Number of Shortest Paths 4365396
Length Of Smallest Path 3
Average Path Length 39.663
Length of Longest Path 63
Minimum Path Strength 1.38
Average Path Strength 6.46827
Maximum Path Strength 25.01
Minimum Path Correlation 0.7
Average Path Correlation 0.986803
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.38095
Average % Of Corr. Nodes 30.3778
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 62.6174
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • heart process   • multicellular organismal process   • system process   • regulation of heart contraction   • regulation of system process   • circulatory system process   • regulation of blood circulation   • regulation of multicellular organismal process   • regulation of biological quality   • heart contraction   • blood circulation   • regulation of heart rate   • metabolic process   • regulation of metabolic process   • regulation of blood pressure   • phospholipase C-activating G protein-coupled receptor signaling pathway   • behavior   • rhythmic process   • circadian behavior   • locomotory behavior   • rhythmic behavior   • circadian rhythm   • locomotor rhythm   • multicellular organismal-level homeostasis   • homoiothermy   • homeostatic process   • temperature homeostasis   • sodium ion homeostasis   • inorganic ion homeostasis   • chemical homeostasis   • monoatomic ion homeostasis   • monoatomic cation homeostasis   • regulation of behavior   • feeding behavior   • regulation of feeding behavior   • regulation of biosynthetic process   • circadian regulation of gene expression   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • regulation of gene expression   • biosynthetic process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • developmental process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • cell-cell signaling   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of primary metabolic process   • regulation of small molecule metabolic process   • positive regulation of biosynthetic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • primary metabolic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of cellular process   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • cilium   • plasma membrane bounded cell projection   • ciliary basal body   • cell projection   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • cell population proliferation   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • synapse   • cell junction   • G-protein beta-subunit binding
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K3F_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRITSGIF 
ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII FVVSSYNRL 
QEALNFKSI WNNRWLRTI SVILFLNKQ DLLAEKVLA GKSKIEDYF 
PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCV DTENRRFND CRDIIQRMH LRQYELLLS ADAVRSMDN 
ADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K3F_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9K3F_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLTP 
VPASENPFR E


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41968
Sequence
>9K3F_Chain_R
CEQVFIKPE VFLSLGIVS LLENILVIL AVVRNGNLH SPMYFFLCS 
LAVADMLVS VSNALETIM IAIVHSDYL TFEDQFIQH MDNIFDSMI 
CISLVASIC NLLAIAVDR YVTIFYALR YHSIMTVRK ALTLIVAIW 
VCCGVCGVV FIVYSESKM VIVCLITMF FAMMLLMGT LYVHMFLFA 
RLHVKRIAA LPPSCMKGA VTITILLGV FIFCWAPFF LHLVLIITC 
PTNPYCICY TAHFNTYLV LIMCNSVID PLIYAFRSL ELRNTF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IOCAPeptideMelanocortinMC3Homo sapiensγ-MSHCachim(NtGi1-Gs)/β1/γ22.862023-09-20doi.org/10.1038/s41421-023-00586-4
8IOC (No Gprot) APeptideMelanocortinMC3Homo sapiensγ-MSHCa2.862023-09-20doi.org/10.1038/s41421-023-00586-4
8KIGAPeptideMelanocortinMC3Homo sapiensSHU9119Ca-3.12025-02-26doi.org/10.2210/pdb8KIG/pdb
8W8WAPeptideMelanocortinMC3Homo sapiensα-MSHCaGs/β1/γ22.92025-03-19To be published
8W8W (No Gprot) APeptideMelanocortinMC3Homo sapiensα-MSHCa2.92025-03-19To be published
8W8XAPeptideMelanocortinMC3Homo sapiensβ-MSHCaGs/β1/γ22.92025-03-19To be published
8W8X (No Gprot) APeptideMelanocortinMC3Homo sapiensβ-MSHCa2.92025-03-19To be published
8W8YAPeptideMelanocortinMC3Homo sapiensγ-MSHCaGs/β1/γ22.92025-03-19To be published
8W8Y (No Gprot) APeptideMelanocortinMC3Homo sapiensγ-MSHCa2.92025-03-19To be published
9K3F (No Gprot) APeptideMelanocortinMC3Homo sapiens--2.752025-08-06doi.org/10.1016/j.str.2025.03.004




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3F.zip



You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.



You can also  read or  download a guide explaining the meaning of all files and numerical data.