psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C276	R:R:C35	7.28	No	No	0	4	4
2	L:L:D9	R:R:Q37	6.53	No	No	0	0	3
3	R:R:H280	R:R:V38	12.45	No	No	0	3	2
4	R:R:F45	R:R:I40	5.02	Yes	No	0	7	5
5	R:R:I40	R:R:N282	7.08	No	No	0	5	3
6	R:R:F45	R:R:T95	9.08	Yes	Yes	5	7	5
7	R:R:F45	R:R:L285	3.65	Yes	No	0	7	3
8	R:R:F45	R:R:M289	6.22	Yes	No	0	7	6
9	L:L:H5	R:R:F45	18.1	No	Yes	5	0	7
10	R:R:L46	R:R:T95	4.42	No	Yes	0	5	5
11	R:R:I96	R:R:L46	5.71	No	No	0	5	5
12	R:R:G49	R:R:S88	3.71	No	No	0	6	8
13	R:R:S52	R:R:S88	6.52	No	No	0	7	8
14	R:R:S52	R:R:V293	4.85	No	No	0	7	5
15	R:R:I57	R:R:L53	4.28	No	No	0	4	6
16	R:R:L53	R:R:M85	4.24	No	No	0	6	6
17	R:R:L53	R:R:V89	5.96	No	No	0	6	5
18	R:R:E55	R:R:V293	4.28	No	No	0	7	5
19	R:R:E55	R:R:P296	4.72	No	No	0	7	9
20	R:R:A81	R:R:N56	4.69	No	No	0	9	9
21	R:R:D84	R:R:N56	8.08	No	No	0	9	9
22	R:R:N56	R:R:P296	9.77	No	No	0	9	9
23	R:R:F310	R:R:L58	9.74	No	No	0	7	7
24	R:R:F301	R:R:V59	3.93	No	No	0	6	9
25	R:R:C78	R:R:V63	5.12	No	No	0	7	8
26	R:R:L306	R:R:V63	4.47	No	No	0	8	8
27	R:R:I313	R:R:R65	15.03	No	No	0	6	5
28	R:R:L69	R:R:N66	9.61	Yes	No	0	8	7
29	R:R:N66	R:R:T309	10.24	No	No	0	7	8
30	R:R:G67	R:R:H70	4.77	No	No	0	5	8
31	R:R:L69	R:R:Y74	9.38	Yes	Yes	2	8	8
32	R:R:E305	R:R:L69	5.3	No	Yes	2	6	8
33	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
34	R:R:M73	R:R:S71	6.13	No	No	2	8	7
35	R:R:S71	R:R:Y74	3.82	No	Yes	2	7	8
36	R:R:M156	R:R:P72	5.03	No	Yes	0	8	6
37	R:R:P72	R:R:V158	3.53	Yes	No	0	6	1
38	R:R:A161	R:R:P72	3.74	No	Yes	0	6	6
39	R:R:M73	R:R:Y74	11.97	No	Yes	2	8	8
40	R:R:L77	R:R:Y74	3.52	No	Yes	0	8	8
41	R:R:S303	R:R:Y74	3.82	No	Yes	2	8	8
42	R:R:E305	R:R:Y74	4.49	No	Yes	2	6	8
43	R:R:L306	R:R:Y74	8.21	No	Yes	2	8	8
44	R:R:F75	R:R:V158	3.93	No	No	0	4	1
45	R:R:F75	R:R:L162	7.31	No	No	0	4	2
46	R:R:A137	R:R:F76	5.55	No	No	0	7	7
47	R:R:D141	R:R:F76	5.97	Yes	No	0	9	7
48	R:R:F76	R:R:I165	5.02	No	No	0	7	7
49	R:R:N134	R:R:S79	10.43	No	No	0	8	9
50	R:R:I165	R:R:S79	4.64	No	No	0	7	9
51	R:R:L80	R:R:N134	4.12	No	No	0	9	8
52	R:R:L135	R:R:L80	5.54	No	No	0	8	9
53	R:R:D84	R:R:S292	8.83	No	No	0	9	9
54	R:R:D295	R:R:D84	9.31	No	No	0	9	9
55	R:R:L86	R:R:W169	3.42	No	No	0	6	9
56	R:R:S127	R:R:V87	6.46	No	No	0	7	8
57	R:R:S292	R:R:V87	4.85	No	No	0	9	8
58	R:R:M123	R:R:S90	9.2	No	No	0	4	5
59	R:R:I124	R:R:S90	4.64	Yes	No	0	4	5
60	R:R:I124	R:R:N91	11.33	Yes	No	0	4	6
61	R:R:M289	R:R:N91	8.41	No	No	0	6	6
62	R:R:F120	R:R:L93	4.87	No	No	0	5	6
63	R:R:D117	R:R:E94	6.5	Yes	Yes	1	3	5
64	R:R:D121	R:R:E94	9.09	Yes	Yes	1	4	5
65	R:R:E94	R:R:I124	4.1	Yes	Yes	0	5	4
66	I:I:?1	R:R:E94	7.31	No	Yes	1	0	5
67	L:L:H5	R:R:T95	6.85	No	Yes	5	0	5
68	R:R:M116	R:R:M97	5.78	No	No	0	5	4
69	R:R:F120	R:R:M97	6.22	No	No	0	5	4
70	L:L:M3	R:R:I98	8.75	Yes	No	0	0	4
71	L:L:H5	R:R:I98	5.3	No	No	0	0	4
72	R:R:I100	R:R:Y105	3.63	No	No	0	3	3
73	R:R:L106	R:R:Y105	19.93	No	No	0	5	3
74	R:R:F108	R:R:F112	6.43	No	No	0	3	1
75	R:R:H115	R:R:Q111	12.36	No	No	0	4	2
76	R:R:F112	R:R:M116	12.44	No	No	0	1	5
77	L:L:Y1	R:R:I113	3.63	No	Yes	0	0	8
78	L:L:M3	R:R:I113	7.29	Yes	Yes	0	0	8
79	L:L:Y1	R:R:Q114	11.27	No	No	0	0	5
80	R:R:D117	R:R:D121	5.32	Yes	Yes	1	3	4
81	L:L:M3	R:R:D117	9.7	Yes	Yes	0	0	3
82	I:I:?1	R:R:D117	7.49	No	Yes	1	0	3
83	R:R:I180	R:R:N118	4.25	Yes	No	1	5	4
84	L:L:R7	R:R:N118	6.03	Yes	No	1	0	4
85	R:R:D121	R:R:I180	4.2	Yes	Yes	1	4	5
86	L:L:F6	R:R:D121	3.58	Yes	Yes	0	0	4
87	L:L:R7	R:R:D121	11.91	Yes	Yes	1	0	4
88	I:I:?1	R:R:D121	9.98	No	Yes	1	0	4
89	R:R:I180	R:R:S122	4.64	Yes	No	0	5	4
90	L:L:F6	R:R:I124	12.56	Yes	Yes	0	0	4
91	R:R:C125	R:R:G176	3.92	No	No	0	4	6
92	R:R:C125	R:R:F179	4.19	No	Yes	0	4	3
93	R:R:G173	R:R:I126	7.05	No	No	0	4	4
94	R:R:L128	R:R:W255	6.83	No	Yes	6	5	8
95	R:R:I288	R:R:L128	4.28	No	No	6	6	5
96	R:R:C172	R:R:V129	6.83	No	No	0	8	5
97	R:R:A130	R:R:W169	7.78	No	No	0	7	9
98	R:R:A130	R:R:C172	3.61	No	No	0	7	8
99	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
100	R:R:I132	R:R:M199	5.83	No	No	0	7	7
101	R:R:I132	R:R:W255	8.22	No	Yes	0	7	8
102	R:R:C133	R:R:C172	3.64	No	No	0	5	8
103	R:R:D295	R:R:L135	8.14	No	No	0	9	8
104	R:R:L135	R:R:Y299	4.69	No	Yes	0	8	9
105	R:R:L136	R:R:M199	4.24	No	No	0	7	7
106	R:R:L136	R:R:L202	6.92	No	No	0	7	5
107	R:R:I138	R:R:R142	3.76	No	No	3	8	9
108	R:R:I138	R:R:Y299	3.63	No	Yes	3	8	9
109	R:R:A139	R:R:Y207	4	No	Yes	0	8	9
110	R:R:D141	R:R:T145	4.34	Yes	No	4	9	8
111	R:R:D141	R:R:Y152	5.75	Yes	Yes	4	9	8
112	R:R:D141	R:R:M156	4.16	Yes	No	4	9	8
113	R:R:R142	R:R:Y207	6.17	No	Yes	3	9	9
114	R:R:R142	R:R:Y299	6.17	No	Yes	3	9	9
115	R:R:F147	R:R:Y143	18.57	Yes	No	7	6	8
116	R:R:L206	R:R:Y143	5.86	Yes	No	0	6	8
117	R:R:H209	R:R:Y143	10.89	No	No	7	6	8
118	R:R:T145	R:R:Y152	9.99	No	Yes	4	8	8
119	R:R:F147	R:R:I146	7.54	Yes	No	0	6	9
120	R:R:F147	R:R:H209	14.71	Yes	No	7	6	6
121	R:R:F147	R:R:F213	7.5	Yes	No	0	6	5
122	R:R:H153	R:R:Y152	7.62	No	Yes	0	5	8
123	R:R:M156	R:R:Y152	8.38	No	Yes	4	8	8
124	R:R:K160	R:R:T157	4.5	No	No	0	7	8
125	R:R:F179	R:R:V188	9.18	Yes	No	0	3	5
126	R:R:C191	R:R:F179	5.59	No	Yes	0	5	3
127	R:R:F179	R:R:L192	8.53	Yes	No	0	3	4
128	L:L:R7	R:R:I180	8.77	Yes	Yes	1	0	5
129	L:L:W8	R:R:I180	4.7	Yes	Yes	1	0	5
130	R:R:S185	R:R:Y182	17.8	No	No	0	4	5
131	L:L:W8	R:R:S183	11.12	Yes	No	0	0	5
132	R:R:I266	R:R:K186	8.72	No	No	1	3	4
133	L:L:F11	R:R:K186	6.2	Yes	No	1	0	4
134	R:R:I189	R:R:L262	7.14	Yes	No	0	6	5
135	R:R:I189	R:R:I266	10.3	Yes	No	1	6	3
136	L:L:W8	R:R:I189	4.7	Yes	Yes	1	0	6
137	L:L:F11	R:R:I189	3.77	Yes	Yes	1	0	6
138	R:R:F259	R:R:I193	3.77	No	No	0	6	4
139	R:R:I193	R:R:L262	4.28	No	No	0	4	5
140	R:R:I193	R:R:V263	6.14	No	No	0	4	5
141	R:R:F196	R:R:F197	6.43	Yes	No	0	7	4
142	R:R:F196	R:R:M200	3.73	Yes	No	0	7	6
143	R:R:F196	R:R:W255	4.01	Yes	Yes	0	7	8
144	R:R:F196	R:R:F259	24.65	Yes	No	0	7	6
145	R:R:M203	R:R:Y207	5.99	No	Yes	0	8	9
146	R:R:F251	R:R:M203	11.2	No	No	0	8	8
147	R:R:G204	R:R:L248	3.42	No	Yes	0	5	7
148	R:R:M210	R:R:Y207	3.59	No	Yes	0	9	9
149	R:R:L247	R:R:Y207	4.69	No	Yes	3	8	9
150	R:R:L248	R:R:Y207	3.52	Yes	Yes	0	7	9
151	R:R:Y207	R:R:Y299	3.97	Yes	Yes	3	9	9
152	R:R:F211	R:R:I244	3.77	No	Yes	0	6	7
153	R:R:F213	R:R:H217	10.18	No	No	0	5	7
154	R:R:K219	R:R:R215	12.38	No	No	0	5	6
155	R:R:C237	R:R:R215	5.57	No	No	0	6	6
156	R:R:S236	R:R:V218	8.08	No	No	0	5	5
157	R:R:L224	R:R:P225	4.93	No	No	0	5	3
158	R:R:P225	R:R:P226	5.84	No	No	0	3	3
159	R:R:M238	R:R:Q234	8.16	No	No	0	4	4
160	R:R:K239	R:R:Q234	4.07	No	No	0	8	4
161	R:R:C237	R:R:H235	5.9	No	No	0	6	4
162	R:R:I298	R:R:L247	4.28	Yes	No	3	9	8
163	R:R:L247	R:R:Y299	7.03	No	Yes	3	8	9
164	R:R:I294	R:R:V250	4.61	No	No	0	6	6
165	R:R:I298	R:R:V250	4.61	Yes	No	0	9	6
166	R:R:F251	R:R:W255	5.01	No	Yes	0	8	8
167	R:R:C254	R:R:N291	6.3	No	No	0	8	9
168	R:R:I288	R:R:W255	8.22	No	Yes	6	6	8
169	R:R:N291	R:R:W255	14.69	No	Yes	0	9	8
170	R:R:P257	R:R:Y284	4.17	No	Yes	0	9	5
171	R:R:F258	R:R:F259	10.72	Yes	No	0	5	6
172	R:R:F258	R:R:L262	6.09	Yes	No	0	5	5
173	R:R:F258	R:R:I288	5.02	Yes	No	0	5	6
174	L:L:F6	R:R:F258	4.29	Yes	Yes	0	0	5
175	R:R:L260	R:R:Y277	11.72	No	No	0	5	1
176	R:R:H261	R:R:I265	9.28	Yes	No	1	5	3
177	R:R:H261	R:R:T278	5.48	Yes	No	1	5	3
178	R:R:F281	R:R:H261	14.71	No	Yes	0	3	5
179	R:R:H261	R:R:Y284	6.53	Yes	Yes	0	5	5
180	R:R:C268	R:R:L264	4.76	Yes	No	8	4	5
181	R:R:C274	R:R:L264	7.94	No	No	8	4	5
182	R:R:L264	R:R:Y277	3.52	No	No	0	5	1
183	R:R:I265	R:R:T278	4.56	No	No	1	3	3
184	L:L:F11	R:R:I265	3.77	Yes	No	1	0	3
185	L:L:F11	R:R:I266	3.77	Yes	No	1	0	3
186	R:R:C268	R:R:C274	7.28	Yes	No	8	4	4
187	R:R:Y277	R:R:Y284	18.86	No	Yes	0	1	5
188	R:R:H280	R:R:T283	5.48	No	No	0	3	4
189	R:R:F281	R:R:L285	6.09	No	No	0	3	3
190	L:L:D9	R:R:F281	17.91	No	No	0	0	3
191	R:R:D295	R:R:N291	12.12	No	No	0	9	9
192	R:R:I298	R:R:Y299	6.04	Yes	Yes	3	9	9
193	R:R:R302	R:R:R307	4.26	No	No	0	8	8
194	R:R:E305	R:R:S303	4.31	No	No	2	6	8
195	R:R:L306	R:R:S303	6.01	No	No	2	8	8
196	L:L:G4	L:L:M3	3.49	No	Yes	0	0	0
197	L:L:F6	L:L:W8	5.01	Yes	Yes	0	0	0
198	L:L:R7	L:L:W8	5	Yes	Yes	1	0	0
199	R:R:A300	R:R:V59	3.39	No	No	0	8	9
200	R:R:L287	R:R:P257	3.28	No	No	0	7	9
201	R:R:C125	R:R:I180	3.27	No	Yes	0	4	5
202	R:R:H280	R:R:Y284	3.27	No	Yes	0	3	5
203	R:R:C133	R:R:M199	3.24	No	No	0	5	7
204	R:R:S122	R:R:V177	3.23	No	No	0	4	4
205	R:R:S185	R:R:V188	3.23	No	No	0	4	5
206	R:R:V286	R:R:V44	3.21	No	No	0	5	4
207	R:R:C290	R:R:L48	3.17	No	No	0	5	6
208	R:R:A300	R:R:L77	3.15	No	No	0	8	8
209	R:R:I126	R:R:S122	3.1	No	No	0	4	4
210	R:R:I155	R:R:V144	3.07	No	No	0	5	6
211	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
212	R:R:M195	R:R:V129	3.04	No	No	0	4	5
213	R:R:M238	R:R:V242	3.04	No	No	0	4	7
214	R:R:I275	R:R:T278	3.04	No	No	0	1	3
215	R:R:F211	R:R:G240	3.01	No	No	0	6	8
216	R:R:L86	R:R:V82	2.98	No	No	0	6	7
217	R:R:L206	R:R:V140	2.98	Yes	No	0	6	6
218	R:R:L212	R:R:V208	2.98	No	No	0	3	3
219	R:R:L206	R:R:T205	2.95	Yes	No	0	6	4
220	R:R:I246	R:R:I298	2.94	No	Yes	0	7	9
221	R:R:I100	R:R:M97	2.92	No	No	0	3	4
222	R:R:I113	R:R:M116	2.92	Yes	No	0	8	5
223	R:R:I252	R:R:M200	2.92	No	No	0	5	6
224	R:R:K186	R:R:M187	2.88	No	No	0	4	5
225	R:R:E184	R:R:S183	2.87	No	No	0	4	5
226	R:R:I244	R:R:L248	2.85	Yes	Yes	0	7	7
227	R:R:L48	R:R:M289	2.83	No	No	0	6	6
228	R:R:I168	R:R:N134	2.83	No	No	0	6	8
229	R:R:C175	R:R:F179	2.79	No	Yes	0	4	3
230	R:R:A256	R:R:F196	2.77	No	Yes	0	5	7
231	R:R:L202	R:R:L206	2.77	No	Yes	0	5	6
232	R:R:A241	R:R:F211	2.77	No	No	0	7	6
233	R:R:L69	R:R:N68	2.75	Yes	No	0	8	7
234	R:R:E312	R:R:I313	2.73	No	No	0	5	6
235	R:R:F45	R:R:V286	2.62	Yes	No	0	7	5
236	R:R:F108	R:R:V101	2.62	No	No	0	3	3
237	R:R:F179	R:R:V178	2.62	Yes	No	0	3	4
238	R:R:Q111	R:R:Q114	2.56	No	No	0	2	5
239	R:R:V144	R:R:Y152	2.52	No	Yes	0	6	8
240	R:R:F301	R:R:L58	2.44	No	No	0	6	7
241	R:R:L216	R:R:R220	2.43	No	No	0	5	6
242	R:R:L304	R:R:R307	2.43	No	No	0	5	8
243	R:R:H217	R:R:R220	2.26	No	No	0	7	6
244	R:R:F147	R:R:Y148	2.06	Yes	No	0	6	5
245	R:R:C268	R:R:P269	1.88	Yes	No	0	4	2
246	R:R:G240	R:R:T243	1.82	No	No	0	8	9
247	R:R:A130	R:R:A83	1.79	No	No	0	7	8
248	R:R:P42	R:R:T95	1.75	No	Yes	0	4	5
249	R:R:G240	R:R:K239	1.74	No	No	0	8	8
250	R:R:C175	R:R:V174	1.71	No	No	0	4	3
251	R:R:G249	R:R:L248	1.71	No	Yes	0	6	7
252	R:R:A279	R:R:V38	1.7	No	No	0	3	2
253	R:R:G67	R:R:N66	1.7	No	No	0	5	7
254	R:R:C268	R:R:T267	1.69	Yes	No	0	4	4
255	R:R:A62	R:R:T309	1.68	No	No	0	8	8
256	R:R:K41	R:R:P42	1.67	No	No	0	4	4
257	R:R:C78	R:R:I60	1.64	No	No	0	7	8
258	R:R:N271	R:R:P272	1.63	No	No	0	4	1
259	R:R:S90	R:R:V89	1.62	No	No	0	5	5
260	R:R:V293	R:R:V51	1.6	No	No	0	5	5
261	R:R:V166	R:R:V170	1.6	No	No	0	5	4
262	R:R:T194	R:R:V190	1.59	No	No	0	4	4
263	R:R:A92	R:R:L46	1.58	No	No	0	6	5
264	R:R:C268	R:R:N271	1.57	Yes	No	0	4	4
265	R:R:M187	R:R:V190	1.52	No	No	0	5	4
266	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
267	R:R:I313	R:R:T309	1.52	No	No	0	6	8
268	R:R:F39	R:R:P42	1.44	No	No	0	4	4
269	R:R:I57	R:R:L61	1.43	No	No	0	4	5
270	R:R:I60	R:R:L61	1.43	No	No	0	8	5
271	R:R:I298	R:R:L297	1.43	Yes	No	0	9	5
272	R:R:D110	R:R:I113	1.4	No	Yes	0	6	8
273	R:R:H235	R:R:S236	1.39	No	No	0	4	5
274	R:R:E43	R:R:K41	1.35	No	No	0	3	4
275	R:R:C274	R:R:Y273	1.34	No	No	0	4	3
276	R:R:H235	R:R:M238	1.31	No	No	0	4	4
277	R:R:R159	R:R:T157	1.29	No	No	0	4	8
278	R:R:F120	R:R:I119	1.26	No	No	0	5	5
279	R:R:N308	R:R:R307	1.21	No	No	0	4	8
280	L:L:D9	L:L:R10	1.19	No	No	0	0	0
281	R:R:E109	R:R:F112	1.17	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F45	7.44833	6	5	7
2	R:R:L69	6.76	4	2	8
3	R:R:P72	3.965	4	0	6
4	R:R:Y74	6.45857	7	2	8
5	R:R:E94	6.75	4	1	5
6	R:R:T95	5.525	4	5	5
7	R:R:I113	3.81	4	0	8
8	R:R:D117	7.2525	4	1	3
9	R:R:D121	7.34667	6	1	4
10	R:R:I124	8.1575	4	0	4
11	R:R:D141	5.055	4	4	9
12	R:R:F147	10.076	5	7	6
13	R:R:Y152	6.852	5	4	8
14	R:R:F179	5.48333	6	0	3
15	R:R:I180	4.97167	6	1	5
16	R:R:I189	6.4775	4	1	6
17	R:R:F196	8.318	5	0	7
18	R:R:L206	3.64	4	0	6
19	R:R:Y207	4.56143	7	3	9
20	R:R:I244	2.8025	4	0	7
21	R:R:L248	2.875	4	0	7
22	R:R:W255	7.41714	7	6	8
23	R:R:F258	6.53	4	0	5
24	R:R:H261	9	4	1	5
25	R:R:C268	3.436	5	8	4
26	R:R:Y284	8.2075	4	0	5
27	R:R:I298	3.86	5	3	9
28	R:R:Y299	5.255	6	3	9
29	L:L:M3	7.3075	4	0	0
30	L:L:F6	6.36	4	0	0
31	L:L:R7	7.9275	4	1	0
32	L:L:W8	6.106	5	1	0
33	L:L:F11	4.3775	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F281	R:R:H261	16.4909	14.71	No	Yes	0	3	5
2	R:R:H261	R:R:Y284	34.476	6.53	Yes	Yes	0	5	5
3	R:R:F281	R:R:L285	14.0568	6.09	No	No	0	3	3
4	R:R:F45	R:R:L285	15.5375	3.65	Yes	No	0	7	3
5	R:R:F45	R:R:T95	11.4064	9.08	Yes	Yes	5	7	5
6	R:R:F45	R:R:M289	27.2143	6.22	Yes	No	0	7	6
7	R:R:H261	R:R:I265	31.3523	9.28	Yes	No	1	5	3
8	L:L:F11	R:R:I265	35.6254	3.77	Yes	No	1	0	3
9	L:L:F11	R:R:I189	43.0291	3.77	Yes	Yes	1	0	6
10	R:R:I189	R:R:L262	31.6903	7.14	Yes	No	0	6	5
11	R:R:F258	R:R:L262	31.5078	6.09	Yes	No	0	5	5
12	R:R:F258	R:R:I288	100	5.02	Yes	No	0	5	6
13	R:R:I288	R:R:W255	98.5869	8.22	No	Yes	6	6	8
14	R:R:N291	R:R:W255	51.4064	14.69	No	Yes	0	9	8
15	R:R:D295	R:R:N291	49.9053	12.12	No	No	0	9	9
16	R:R:D295	R:R:D84	22.407	9.31	No	No	0	9	9
17	R:R:D84	R:R:N56	15.7539	8.08	No	No	0	9	9
18	R:R:N56	R:R:P296	12.3462	9.77	No	No	0	9	9
19	R:R:E55	R:R:P296	10.622	4.72	No	No	0	7	9
20	R:R:M289	R:R:N91	30.764	8.41	No	No	0	6	6
21	R:R:I124	R:R:N91	32.2312	11.33	Yes	No	0	4	6
22	R:R:I124	R:R:S90	51.5416	4.64	Yes	No	0	4	5
23	R:R:S90	R:R:V89	48.4314	1.62	No	No	0	5	5
24	R:R:L53	R:R:V89	46.883	5.96	No	No	0	6	5
25	R:R:I57	R:R:L53	43.7728	4.28	No	No	0	4	6
26	R:R:I57	R:R:L61	42.211	1.43	No	No	0	4	5
27	R:R:I60	R:R:L61	40.6626	1.43	No	No	0	8	5
28	R:R:C78	R:R:I60	39.1143	1.64	No	No	0	7	8
29	R:R:C78	R:R:V63	37.762	5.12	No	No	0	7	8
30	R:R:L306	R:R:V63	36.9236	4.47	No	No	0	8	8
31	R:R:L306	R:R:Y74	33.4077	8.21	No	Yes	2	8	8
32	R:R:L77	R:R:Y74	12.4476	3.52	No	Yes	0	8	8
33	R:R:A300	R:R:L77	10.4057	3.15	No	No	0	8	8
34	R:R:L69	R:R:Y74	20.4124	9.38	Yes	Yes	2	8	8
35	R:R:L69	R:R:N66	16.545	9.61	Yes	No	0	8	7
36	R:R:N66	R:R:T309	10.4395	10.24	No	No	0	7	8
37	R:R:S71	R:R:Y74	23.259	3.82	No	Yes	2	7	8
38	R:R:P72	R:R:S71	23.3874	3.56	Yes	No	0	6	7
39	R:R:D295	R:R:L135	40.4395	8.14	No	No	0	9	8
40	R:R:L135	R:R:L80	37.6065	5.54	No	No	0	8	9
41	R:R:L80	R:R:N134	36.3827	4.12	No	No	0	9	8
42	R:R:N134	R:R:S79	33.9216	10.43	No	No	0	8	9
43	R:R:I165	R:R:S79	32.6842	4.64	No	No	0	7	9
44	R:R:F76	R:R:I165	31.4604	5.02	No	No	0	7	7
45	R:R:D141	R:R:F76	28.9993	5.97	Yes	No	0	9	7
46	R:R:D141	R:R:M156	20.5409	4.16	Yes	No	4	9	8
47	R:R:M156	R:R:P72	21.5619	5.03	No	Yes	0	8	6
48	R:R:I132	R:R:W255	43.1711	8.22	No	Yes	0	7	8
49	R:R:I132	R:R:M199	41.6024	5.83	No	No	0	7	7
50	R:R:C133	R:R:M199	16.545	3.24	No	No	0	5	7
51	R:R:C133	R:R:C172	14.76	3.64	No	No	0	5	8
52	L:L:M3	R:R:I98	10.6153	8.75	Yes	No	0	0	4
53	L:L:M3	R:R:I113	33.4483	7.29	Yes	Yes	0	0	8
54	R:R:I113	R:R:M116	22.7721	2.92	Yes	No	0	8	5
55	R:R:M116	R:R:M97	13.4686	5.78	No	No	0	5	4
56	L:L:M3	R:R:D117	35.6254	9.7	Yes	Yes	0	0	3
57	R:R:E94	R:R:I124	14.6586	4.1	Yes	Yes	0	5	4
58	L:L:W8	R:R:I189	23.0291	4.7	Yes	Yes	1	0	6
59	L:L:W8	R:R:I180	26.8492	4.7	Yes	Yes	1	0	5
60	R:R:D121	R:R:I180	32.2042	4.2	Yes	Yes	1	4	5
61	L:L:F6	L:L:W8	36.8965	5.01	Yes	Yes	0	0	0
62	L:L:F6	R:R:D121	45.5781	3.58	Yes	Yes	0	0	4
63	L:L:F6	R:R:I124	49.6349	12.56	Yes	Yes	0	0	4
64	R:R:D117	R:R:D121	30.6018	5.32	Yes	Yes	1	3	4
65	R:R:I180	R:R:S122	12.8668	4.64	Yes	No	0	5	4
66	R:R:C125	R:R:I180	34.7735	3.27	No	Yes	0	4	5
67	R:R:C125	R:R:F179	28.5531	4.19	No	Yes	0	4	3
68	R:R:F251	R:R:W255	48.4246	5.01	No	Yes	0	8	8
69	R:R:F251	R:R:M203	47.3969	11.2	No	No	0	8	8
70	R:R:M203	R:R:Y207	46.7478	5.99	No	Yes	0	8	9
71	R:R:Y207	R:R:Y299	19.5673	3.97	Yes	Yes	3	9	9
72	R:R:L135	R:R:Y299	21.9946	4.69	No	Yes	0	8	9
73	R:R:L136	R:R:M199	25.1724	4.24	No	No	0	7	7
74	R:R:L136	R:R:L202	23.455	6.92	No	No	0	7	5
75	R:R:L202	R:R:L206	21.7241	2.77	No	Yes	0	5	6
76	R:R:L206	R:R:Y143	16.4503	5.86	Yes	No	0	6	8
77	R:R:F147	R:R:Y143	12.8195	18.57	Yes	No	7	6	8
78	R:R:L248	R:R:Y207	35.835	3.52	Yes	Yes	0	7	9
79	R:R:I244	R:R:L248	31.0615	2.85	Yes	Yes	0	7	7
80	R:R:F211	R:R:I244	24.4692	3.77	No	Yes	0	6	7
81	R:R:F211	R:R:G240	21.0886	3.01	No	No	0	6	8
82	R:R:G240	R:R:K239	17.789	1.74	No	No	0	8	8
83	R:R:K239	R:R:Q234	16.0581	4.07	No	No	0	8	4
84	R:R:M238	R:R:Q234	14.3137	8.16	No	No	0	4	4
85	R:R:H235	R:R:M238	10.7843	1.31	No	No	0	4	4
86	R:R:I298	R:R:Y299	14.618	6.04	Yes	Yes	3	9	9
87	R:R:Y277	R:R:Y284	20.7505	18.86	No	Yes	0	1	5
88	R:R:L264	R:R:Y277	16.7072	3.52	No	No	0	5	1
89	R:R:C268	R:R:L264	10.4733	4.76	Yes	No	8	4	5
90	R:R:K186	R:R:M187	11.9811	2.88	No	No	0	4	5
91	L:L:F6	R:R:F258	79.3847	4.29	Yes	Yes	0	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D9	R:R:Q37	6.53	0	No	No	0	3	0	1
R:R:F45	R:R:I40	5.02	5	Yes	No	7	5	1	2
R:R:F45	R:R:T95	9.08	5	Yes	Yes	7	5	1	1
R:R:F45	R:R:L285	3.65	5	Yes	No	7	3	1	2
R:R:F45	R:R:M289	6.22	5	Yes	No	7	6	1	2
L:L:H5	R:R:F45	18.1	5	No	Yes	0	7	0	1
R:R:L46	R:R:T95	4.42	0	No	Yes	5	5	2	1
R:R:I124	R:R:S90	4.64	0	Yes	No	4	5	1	2
R:R:I124	R:R:N91	11.33	0	Yes	No	4	6	1	2
R:R:M289	R:R:N91	8.41	0	No	No	6	6	2	2
R:R:D117	R:R:E94	6.5	1	Yes	Yes	3	5	1	2
R:R:D121	R:R:E94	9.09	1	Yes	Yes	4	5	1	2
R:R:E94	R:R:I124	4.1	1	Yes	Yes	5	4	2	1
I:I:?1	R:R:E94	7.31	1	No	Yes	0	5	2	2
L:L:H5	R:R:T95	6.85	5	No	Yes	0	5	0	1
L:L:M3	R:R:I98	8.75	0	Yes	No	0	4	0	1
L:L:H5	R:R:I98	5.3	5	No	No	0	4	0	1
L:L:Y1	R:R:I113	3.63	0	No	Yes	0	8	0	1
L:L:M3	R:R:I113	7.29	0	Yes	Yes	0	8	0	1
L:L:Y1	R:R:Q114	11.27	0	No	No	0	5	0	1
R:R:D117	R:R:D121	5.32	1	Yes	Yes	3	4	1	1
L:L:M3	R:R:D117	9.7	0	Yes	Yes	0	3	0	1
I:I:?1	R:R:D117	7.49	1	No	Yes	0	3	2	1
R:R:I180	R:R:N118	4.25	1	Yes	No	5	4	1	1
L:L:R7	R:R:N118	6.03	1	Yes	No	0	4	0	1
R:R:D121	R:R:I180	4.2	1	Yes	Yes	4	5	1	1
L:L:F6	R:R:D121	3.58	0	Yes	Yes	0	4	0	1
L:L:R7	R:R:D121	11.91	1	Yes	Yes	0	4	0	1
I:I:?1	R:R:D121	9.98	1	No	Yes	0	4	2	1
R:R:I180	R:R:S122	4.64	1	Yes	No	5	4	1	2
L:L:F6	R:R:I124	12.56	0	Yes	Yes	0	4	0	1
L:L:R7	R:R:I180	8.77	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:I180	4.7	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:S183	11.12	1	Yes	No	0	5	0	1
R:R:I266	R:R:K186	8.72	1	No	No	3	4	1	1
L:L:F11	R:R:K186	6.2	1	Yes	No	0	4	0	1
R:R:I189	R:R:L262	7.14	1	Yes	No	6	5	1	2
R:R:I189	R:R:I266	10.3	1	Yes	No	6	3	1	1
L:L:W8	R:R:I189	4.7	1	Yes	Yes	0	6	0	1
L:L:F11	R:R:I189	3.77	1	Yes	Yes	0	6	0	1
R:R:F258	R:R:F259	10.72	0	Yes	No	5	6	1	2
R:R:F258	R:R:L262	6.09	0	Yes	No	5	5	1	2
R:R:F258	R:R:I288	5.02	0	Yes	No	5	6	1	2
L:L:F6	R:R:F258	4.29	0	Yes	Yes	0	5	0	1
R:R:H261	R:R:I265	9.28	1	Yes	No	5	3	2	1
R:R:H261	R:R:T278	5.48	1	Yes	No	5	3	2	2
R:R:F281	R:R:H261	14.71	0	No	Yes	3	5	1	2
R:R:I265	R:R:T278	4.56	1	No	No	3	3	1	2
L:L:F11	R:R:I265	3.77	1	Yes	No	0	3	0	1
L:L:F11	R:R:I266	3.77	1	Yes	No	0	3	0	1
R:R:F281	R:R:L285	6.09	0	No	No	3	3	1	2
L:L:D9	R:R:F281	17.91	0	No	No	0	3	0	1
R:R:C125	R:R:I180	3.27	0	No	Yes	4	5	2	1
R:R:I113	R:R:M116	2.92	0	Yes	No	8	5	1	2
R:R:K186	R:R:M187	2.88	1	No	No	4	5	1	2
R:R:E184	R:R:S183	2.87	0	No	No	4	5	2	1
R:R:F45	R:R:V286	2.62	5	Yes	No	7	5	1	2
R:R:Q111	R:R:Q114	2.56	0	No	No	2	5	2	1
R:R:P42	R:R:T95	1.75	0	No	Yes	4	5	2	1
R:R:D110	R:R:I113	1.4	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IOC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	255
Number of Links	281
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	38958
Length Of Smallest Path	3
Average Path Length	13.6851
Length of Longest Path	31
Minimum Path Strength	1.35
Average Path Strength	6.12258
Maximum Path Strength	17.685
Minimum Path Correlation	0.7
Average Path Correlation	0.936224
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.9891
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1202
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>8IOC_nogp_Chain_R C E Q V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L P P Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F R E I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Gamma-MSH
UniProt	P01189
Sequence	>8IOC_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8IOC_nogp.zip

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