psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C276	R:R:C35	7.28	No	No	0	4	4
2	L:L:D9	R:R:Q37	6.53	No	No	0	0	3
3	R:R:H280	R:R:V38	12.45	No	No	0	3	2
4	R:R:F45	R:R:I40	5.02	Yes	No	0	7	5
5	R:R:I40	R:R:N282	7.08	No	No	0	5	3
6	R:R:F45	R:R:T95	9.08	Yes	Yes	5	7	5
7	R:R:F45	R:R:L285	3.65	Yes	No	0	7	3
8	R:R:F45	R:R:M289	6.22	Yes	No	0	7	6
9	L:L:H5	R:R:F45	18.1	No	Yes	5	0	7
10	R:R:L46	R:R:T95	4.42	No	Yes	0	5	5
11	R:R:I96	R:R:L46	5.71	No	No	0	5	5
12	R:R:G49	R:R:S88	3.71	No	No	0	6	8
13	R:R:S52	R:R:S88	6.52	No	No	0	7	8
14	R:R:S52	R:R:V293	4.85	No	No	0	7	5
15	R:R:I57	R:R:L53	4.28	No	No	0	4	6
16	R:R:L53	R:R:M85	4.24	No	No	0	6	6
17	R:R:L53	R:R:V89	5.96	No	No	0	6	5
18	R:R:E55	R:R:V293	4.28	No	No	0	7	5
19	R:R:E55	R:R:P296	4.72	No	No	0	7	9
20	R:R:A81	R:R:N56	4.69	No	No	0	9	9
21	R:R:D84	R:R:N56	8.08	No	No	0	9	9
22	R:R:N56	R:R:P296	9.77	No	No	0	9	9
23	R:R:F310	R:R:L58	9.74	No	No	0	7	7
24	R:R:F301	R:R:V59	3.93	No	No	0	6	9
25	R:R:C78	R:R:V63	5.12	No	No	0	7	8
26	R:R:L306	R:R:V63	4.47	No	No	0	8	8
27	R:R:I313	R:R:R65	15.03	No	No	0	6	5
28	R:R:L69	R:R:N66	9.61	Yes	No	0	8	7
29	R:R:N66	R:R:T309	10.24	No	No	0	7	8
30	R:R:G67	R:R:H70	4.77	No	No	0	5	8
31	R:R:L69	R:R:Y74	9.38	Yes	Yes	2	8	8
32	R:R:E305	R:R:L69	5.3	No	Yes	2	6	8
33	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
34	R:R:M73	R:R:S71	6.13	No	No	2	8	7
35	R:R:S71	R:R:Y74	3.82	No	Yes	2	7	8
36	R:R:M156	R:R:P72	5.03	No	Yes	0	8	6
37	R:R:P72	R:R:V158	3.53	Yes	No	0	6	1
38	R:R:A161	R:R:P72	3.74	No	Yes	0	6	6
39	R:R:M73	R:R:Y74	11.97	No	Yes	2	8	8
40	R:R:L77	R:R:Y74	3.52	No	Yes	0	8	8
41	R:R:S303	R:R:Y74	3.82	No	Yes	2	8	8
42	R:R:E305	R:R:Y74	4.49	No	Yes	2	6	8
43	R:R:L306	R:R:Y74	8.21	No	Yes	2	8	8
44	R:R:F75	R:R:V158	3.93	No	No	0	4	1
45	R:R:F75	R:R:L162	7.31	No	No	0	4	2
46	R:R:A137	R:R:F76	5.55	No	No	0	7	7
47	R:R:D141	R:R:F76	5.97	Yes	No	0	9	7
48	R:R:F76	R:R:I165	5.02	No	No	0	7	7
49	R:R:N134	R:R:S79	10.43	No	No	0	8	9
50	R:R:I165	R:R:S79	4.64	No	No	0	7	9
51	R:R:L80	R:R:N134	4.12	No	No	0	9	8
52	R:R:L135	R:R:L80	5.54	No	No	0	8	9
53	R:R:D84	R:R:S292	8.83	No	No	0	9	9
54	R:R:D295	R:R:D84	9.31	No	No	0	9	9
55	R:R:L86	R:R:W169	3.42	No	No	0	6	9
56	R:R:S127	R:R:V87	6.46	No	No	0	7	8
57	R:R:S292	R:R:V87	4.85	No	No	0	9	8
58	R:R:M123	R:R:S90	9.2	No	No	0	4	5
59	R:R:I124	R:R:S90	4.64	Yes	No	0	4	5
60	R:R:I124	R:R:N91	11.33	Yes	No	0	4	6
61	R:R:M289	R:R:N91	8.41	No	No	0	6	6
62	R:R:F120	R:R:L93	4.87	No	No	0	5	6
63	R:R:D117	R:R:E94	6.5	Yes	Yes	1	3	5
64	R:R:D121	R:R:E94	9.09	Yes	Yes	1	4	5
65	R:R:E94	R:R:I124	4.1	Yes	Yes	0	5	4
66	I:I:?1	R:R:E94	7.31	No	Yes	1	0	5
67	L:L:H5	R:R:T95	6.85	No	Yes	5	0	5
68	R:R:M116	R:R:M97	5.78	No	No	0	5	4
69	R:R:F120	R:R:M97	6.22	No	No	0	5	4
70	L:L:M3	R:R:I98	8.75	Yes	No	0	0	4
71	L:L:H5	R:R:I98	5.3	No	No	0	0	4
72	R:R:I100	R:R:Y105	3.63	No	No	0	3	3
73	R:R:L106	R:R:Y105	19.93	No	No	0	5	3
74	R:R:F108	R:R:F112	6.43	No	No	0	3	1
75	R:R:H115	R:R:Q111	12.36	No	No	0	4	2
76	R:R:F112	R:R:M116	12.44	No	No	0	1	5
77	L:L:Y1	R:R:I113	3.63	No	Yes	0	0	8
78	L:L:M3	R:R:I113	7.29	Yes	Yes	0	0	8
79	L:L:Y1	R:R:Q114	11.27	No	No	0	0	5
80	R:R:D117	R:R:D121	5.32	Yes	Yes	1	3	4
81	L:L:M3	R:R:D117	9.7	Yes	Yes	0	0	3
82	I:I:?1	R:R:D117	7.49	No	Yes	1	0	3
83	R:R:I180	R:R:N118	4.25	Yes	No	1	5	4
84	L:L:R7	R:R:N118	6.03	Yes	No	1	0	4
85	R:R:D121	R:R:I180	4.2	Yes	Yes	1	4	5
86	L:L:F6	R:R:D121	3.58	Yes	Yes	0	0	4
87	L:L:R7	R:R:D121	11.91	Yes	Yes	1	0	4
88	I:I:?1	R:R:D121	9.98	No	Yes	1	0	4
89	R:R:I180	R:R:S122	4.64	Yes	No	0	5	4
90	L:L:F6	R:R:I124	12.56	Yes	Yes	0	0	4
91	R:R:C125	R:R:G176	3.92	No	No	0	4	6
92	R:R:C125	R:R:F179	4.19	No	Yes	0	4	3
93	R:R:G173	R:R:I126	7.05	No	No	0	4	4
94	R:R:L128	R:R:W255	6.83	No	Yes	6	5	8
95	R:R:I288	R:R:L128	4.28	No	No	6	6	5
96	R:R:C172	R:R:V129	6.83	No	No	0	8	5
97	R:R:A130	R:R:W169	7.78	No	No	0	7	9
98	R:R:A130	R:R:C172	3.61	No	No	0	7	8
99	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
100	R:R:I132	R:R:M199	5.83	No	No	0	7	7
101	R:R:I132	R:R:W255	8.22	No	Yes	0	7	8
102	R:R:C133	R:R:C172	3.64	No	No	0	5	8
103	R:R:D295	R:R:L135	8.14	No	No	0	9	8
104	R:R:L135	R:R:Y299	4.69	No	Yes	0	8	9
105	R:R:L136	R:R:M199	4.24	No	No	0	7	7
106	R:R:L136	R:R:L202	6.92	No	No	0	7	5
107	R:R:I138	R:R:R142	3.76	No	No	3	8	9
108	R:R:I138	R:R:Y299	3.63	No	Yes	3	8	9
109	R:R:A139	R:R:Y207	4	No	Yes	0	8	9
110	R:R:D141	R:R:T145	4.34	Yes	No	4	9	8
111	R:R:D141	R:R:Y152	5.75	Yes	Yes	4	9	8
112	R:R:D141	R:R:M156	4.16	Yes	No	4	9	8
113	R:R:R142	R:R:Y207	6.17	No	Yes	3	9	9
114	R:R:R142	R:R:Y299	6.17	No	Yes	3	9	9
115	R:R:F147	R:R:Y143	18.57	Yes	No	7	6	8
116	R:R:L206	R:R:Y143	5.86	Yes	No	0	6	8
117	R:R:H209	R:R:Y143	10.89	No	No	7	6	8
118	R:R:T145	R:R:Y152	9.99	No	Yes	4	8	8
119	R:R:F147	R:R:I146	7.54	Yes	No	0	6	9
120	R:R:F147	R:R:H209	14.71	Yes	No	7	6	6
121	R:R:F147	R:R:F213	7.5	Yes	No	0	6	5
122	R:R:H153	R:R:Y152	7.62	No	Yes	0	5	8
123	R:R:M156	R:R:Y152	8.38	No	Yes	4	8	8
124	R:R:K160	R:R:T157	4.5	No	No	0	7	8
125	R:R:F179	R:R:V188	9.18	Yes	No	0	3	5
126	R:R:C191	R:R:F179	5.59	No	Yes	0	5	3
127	R:R:F179	R:R:L192	8.53	Yes	No	0	3	4
128	L:L:R7	R:R:I180	8.77	Yes	Yes	1	0	5
129	L:L:W8	R:R:I180	4.7	Yes	Yes	1	0	5
130	R:R:S185	R:R:Y182	17.8	No	No	0	4	5
131	L:L:W8	R:R:S183	11.12	Yes	No	0	0	5
132	R:R:I266	R:R:K186	8.72	No	No	1	3	4
133	L:L:F11	R:R:K186	6.2	Yes	No	1	0	4
134	R:R:I189	R:R:L262	7.14	Yes	No	0	6	5
135	R:R:I189	R:R:I266	10.3	Yes	No	1	6	3
136	L:L:W8	R:R:I189	4.7	Yes	Yes	1	0	6
137	L:L:F11	R:R:I189	3.77	Yes	Yes	1	0	6
138	R:R:F259	R:R:I193	3.77	No	No	0	6	4
139	R:R:I193	R:R:L262	4.28	No	No	0	4	5
140	R:R:I193	R:R:V263	6.14	No	No	0	4	5
141	R:R:F196	R:R:F197	6.43	Yes	No	0	7	4
142	R:R:F196	R:R:M200	3.73	Yes	No	0	7	6
143	R:R:F196	R:R:W255	4.01	Yes	Yes	0	7	8
144	R:R:F196	R:R:F259	24.65	Yes	No	0	7	6
145	R:R:M203	R:R:Y207	5.99	No	Yes	0	8	9
146	R:R:F251	R:R:M203	11.2	No	No	0	8	8
147	R:R:G204	R:R:L248	3.42	No	Yes	0	5	7
148	R:R:M210	R:R:Y207	3.59	No	Yes	0	9	9
149	R:R:L247	R:R:Y207	4.69	No	Yes	3	8	9
150	R:R:L248	R:R:Y207	3.52	Yes	Yes	0	7	9
151	R:R:Y207	R:R:Y299	3.97	Yes	Yes	3	9	9
152	R:R:F211	R:R:I244	3.77	No	Yes	0	6	7
153	R:R:F213	R:R:H217	10.18	No	No	0	5	7
154	R:R:K219	R:R:R215	12.38	No	No	0	5	6
155	R:R:C237	R:R:R215	5.57	No	No	0	6	6
156	R:R:S236	R:R:V218	8.08	No	No	0	5	5
157	R:R:L224	R:R:P225	4.93	No	No	0	5	3
158	R:R:P225	R:R:P226	5.84	No	No	0	3	3
159	R:R:M238	R:R:Q234	8.16	No	No	0	4	4
160	R:R:K239	R:R:Q234	4.07	No	No	0	8	4
161	R:R:C237	R:R:H235	5.9	No	No	0	6	4
162	R:R:I298	R:R:L247	4.28	Yes	No	3	9	8
163	R:R:L247	R:R:Y299	7.03	No	Yes	3	8	9
164	R:R:I294	R:R:V250	4.61	No	No	0	6	6
165	R:R:I298	R:R:V250	4.61	Yes	No	0	9	6
166	R:R:F251	R:R:W255	5.01	No	Yes	0	8	8
167	R:R:C254	R:R:N291	6.3	No	No	0	8	9
168	R:R:I288	R:R:W255	8.22	No	Yes	6	6	8
169	R:R:N291	R:R:W255	14.69	No	Yes	0	9	8
170	R:R:P257	R:R:Y284	4.17	No	Yes	0	9	5
171	R:R:F258	R:R:F259	10.72	Yes	No	0	5	6
172	R:R:F258	R:R:L262	6.09	Yes	No	0	5	5
173	R:R:F258	R:R:I288	5.02	Yes	No	0	5	6
174	L:L:F6	R:R:F258	4.29	Yes	Yes	0	0	5
175	R:R:L260	R:R:Y277	11.72	No	No	0	5	1
176	R:R:H261	R:R:I265	9.28	Yes	No	1	5	3
177	R:R:H261	R:R:T278	5.48	Yes	No	1	5	3
178	R:R:F281	R:R:H261	14.71	No	Yes	0	3	5
179	R:R:H261	R:R:Y284	6.53	Yes	Yes	0	5	5
180	R:R:C268	R:R:L264	4.76	Yes	No	8	4	5
181	R:R:C274	R:R:L264	7.94	No	No	8	4	5
182	R:R:L264	R:R:Y277	3.52	No	No	0	5	1
183	R:R:I265	R:R:T278	4.56	No	No	1	3	3
184	L:L:F11	R:R:I265	3.77	Yes	No	1	0	3
185	L:L:F11	R:R:I266	3.77	Yes	No	1	0	3
186	R:R:C268	R:R:C274	7.28	Yes	No	8	4	4
187	R:R:Y277	R:R:Y284	18.86	No	Yes	0	1	5
188	R:R:H280	R:R:T283	5.48	No	No	0	3	4
189	R:R:F281	R:R:L285	6.09	No	No	0	3	3
190	L:L:D9	R:R:F281	17.91	No	No	0	0	3
191	R:R:D295	R:R:N291	12.12	No	No	0	9	9
192	R:R:I298	R:R:Y299	6.04	Yes	Yes	3	9	9
193	R:R:R302	R:R:R307	4.26	No	No	0	8	8
194	R:R:E305	R:R:S303	4.31	No	No	2	6	8
195	R:R:L306	R:R:S303	6.01	No	No	2	8	8
196	L:L:G4	L:L:M3	3.49	No	Yes	0	0	0
197	L:L:F6	L:L:W8	5.01	Yes	Yes	0	0	0
198	L:L:R7	L:L:W8	5	Yes	Yes	1	0	0
199	R:R:A300	R:R:V59	3.39	No	No	0	8	9
200	R:R:L287	R:R:P257	3.28	No	No	0	7	9
201	R:R:C125	R:R:I180	3.27	No	Yes	0	4	5
202	R:R:H280	R:R:Y284	3.27	No	Yes	0	3	5
203	R:R:C133	R:R:M199	3.24	No	No	0	5	7
204	R:R:S122	R:R:V177	3.23	No	No	0	4	4
205	R:R:S185	R:R:V188	3.23	No	No	0	4	5
206	R:R:V286	R:R:V44	3.21	No	No	0	5	4
207	R:R:C290	R:R:L48	3.17	No	No	0	5	6
208	R:R:A300	R:R:L77	3.15	No	No	0	8	8
209	R:R:I126	R:R:S122	3.1	No	No	0	4	4
210	R:R:I155	R:R:V144	3.07	No	No	0	5	6
211	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
212	R:R:M195	R:R:V129	3.04	No	No	0	4	5
213	R:R:M238	R:R:V242	3.04	No	No	0	4	7
214	R:R:I275	R:R:T278	3.04	No	No	0	1	3
215	R:R:F211	R:R:G240	3.01	No	No	0	6	8
216	R:R:L86	R:R:V82	2.98	No	No	0	6	7
217	R:R:L206	R:R:V140	2.98	Yes	No	0	6	6
218	R:R:L212	R:R:V208	2.98	No	No	0	3	3
219	R:R:L206	R:R:T205	2.95	Yes	No	0	6	4
220	R:R:I246	R:R:I298	2.94	No	Yes	0	7	9
221	R:R:I100	R:R:M97	2.92	No	No	0	3	4
222	R:R:I113	R:R:M116	2.92	Yes	No	0	8	5
223	R:R:I252	R:R:M200	2.92	No	No	0	5	6
224	R:R:K186	R:R:M187	2.88	No	No	0	4	5
225	R:R:E184	R:R:S183	2.87	No	No	0	4	5
226	R:R:I244	R:R:L248	2.85	Yes	Yes	0	7	7
227	R:R:L48	R:R:M289	2.83	No	No	0	6	6
228	R:R:I168	R:R:N134	2.83	No	No	0	6	8
229	R:R:C175	R:R:F179	2.79	No	Yes	0	4	3
230	R:R:A256	R:R:F196	2.77	No	Yes	0	5	7
231	R:R:L202	R:R:L206	2.77	No	Yes	0	5	6
232	R:R:A241	R:R:F211	2.77	No	No	0	7	6
233	R:R:L69	R:R:N68	2.75	Yes	No	0	8	7
234	R:R:E312	R:R:I313	2.73	No	No	0	5	6
235	R:R:F45	R:R:V286	2.62	Yes	No	0	7	5
236	R:R:F108	R:R:V101	2.62	No	No	0	3	3
237	R:R:F179	R:R:V178	2.62	Yes	No	0	3	4
238	R:R:Q111	R:R:Q114	2.56	No	No	0	2	5
239	R:R:V144	R:R:Y152	2.52	No	Yes	0	6	8
240	R:R:F301	R:R:L58	2.44	No	No	0	6	7
241	R:R:L216	R:R:R220	2.43	No	No	0	5	6
242	R:R:L304	R:R:R307	2.43	No	No	0	5	8
243	R:R:H217	R:R:R220	2.26	No	No	0	7	6
244	R:R:F147	R:R:Y148	2.06	Yes	No	0	6	5
245	R:R:C268	R:R:P269	1.88	Yes	No	0	4	2
246	R:R:G240	R:R:T243	1.82	No	No	0	8	9
247	R:R:A130	R:R:A83	1.79	No	No	0	7	8
248	R:R:P42	R:R:T95	1.75	No	Yes	0	4	5
249	R:R:G240	R:R:K239	1.74	No	No	0	8	8
250	R:R:C175	R:R:V174	1.71	No	No	0	4	3
251	R:R:G249	R:R:L248	1.71	No	Yes	0	6	7
252	R:R:A279	R:R:V38	1.7	No	No	0	3	2
253	R:R:G67	R:R:N66	1.7	No	No	0	5	7
254	R:R:C268	R:R:T267	1.69	Yes	No	0	4	4
255	R:R:A62	R:R:T309	1.68	No	No	0	8	8
256	R:R:K41	R:R:P42	1.67	No	No	0	4	4
257	R:R:C78	R:R:I60	1.64	No	No	0	7	8
258	R:R:N271	R:R:P272	1.63	No	No	0	4	1
259	R:R:S90	R:R:V89	1.62	No	No	0	5	5
260	R:R:V293	R:R:V51	1.6	No	No	0	5	5
261	R:R:V166	R:R:V170	1.6	No	No	0	5	4
262	R:R:T194	R:R:V190	1.59	No	No	0	4	4
263	R:R:A92	R:R:L46	1.58	No	No	0	6	5
264	R:R:C268	R:R:N271	1.57	Yes	No	0	4	4
265	R:R:M187	R:R:V190	1.52	No	No	0	5	4
266	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
267	R:R:I313	R:R:T309	1.52	No	No	0	6	8
268	R:R:F39	R:R:P42	1.44	No	No	0	4	4
269	R:R:I57	R:R:L61	1.43	No	No	0	4	5
270	R:R:I60	R:R:L61	1.43	No	No	0	8	5
271	R:R:I298	R:R:L297	1.43	Yes	No	0	9	5
272	R:R:D110	R:R:I113	1.4	No	Yes	0	6	8
273	R:R:H235	R:R:S236	1.39	No	No	0	4	5
274	R:R:E43	R:R:K41	1.35	No	No	0	3	4
275	R:R:C274	R:R:Y273	1.34	No	No	0	4	3
276	R:R:H235	R:R:M238	1.31	No	No	0	4	4
277	R:R:R159	R:R:T157	1.29	No	No	0	4	8
278	R:R:F120	R:R:I119	1.26	No	No	0	5	5
279	R:R:N308	R:R:R307	1.21	No	No	0	4	8
280	L:L:D9	L:L:R10	1.19	No	No	0	0	0
281	R:R:E109	R:R:F112	1.17	No	No	0	3	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F45	7.44833	6	5	7
2	R:R:L69	6.76	4	2	8
3	R:R:P72	3.965	4	0	6
4	R:R:Y74	6.45857	7	2	8
5	R:R:E94	6.75	4	1	5
6	R:R:T95	5.525	4	5	5
7	R:R:I113	3.81	4	0	8
8	R:R:D117	7.2525	4	1	3
9	R:R:D121	7.34667	6	1	4
10	R:R:I124	8.1575	4	0	4
11	R:R:D141	5.055	4	4	9
12	R:R:F147	10.076	5	7	6
13	R:R:Y152	6.852	5	4	8
14	R:R:F179	5.48333	6	0	3
15	R:R:I180	4.97167	6	1	5
16	R:R:I189	6.4775	4	1	6
17	R:R:F196	8.318	5	0	7
18	R:R:L206	3.64	4	0	6
19	R:R:Y207	4.56143	7	3	9
20	R:R:I244	2.8025	4	0	7
21	R:R:L248	2.875	4	0	7
22	R:R:W255	7.41714	7	6	8
23	R:R:F258	6.53	4	0	5
24	R:R:H261	9	4	1	5
25	R:R:C268	3.436	5	8	4
26	R:R:Y284	8.2075	4	0	5
27	R:R:I298	3.86	5	3	9
28	R:R:Y299	5.255	6	3	9
29	L:L:M3	7.3075	4	0	0
30	L:L:F6	6.36	4	0	0
31	L:L:R7	7.9275	4	1	0
32	L:L:W8	6.106	5	1	0
33	L:L:F11	4.3775	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F281	R:R:H261	16.4909	14.71	No	Yes	0	3	5
2	R:R:H261	R:R:Y284	34.476	6.53	Yes	Yes	0	5	5
3	R:R:F281	R:R:L285	14.0568	6.09	No	No	0	3	3
4	R:R:F45	R:R:L285	15.5375	3.65	Yes	No	0	7	3
5	R:R:F45	R:R:T95	11.4064	9.08	Yes	Yes	5	7	5
6	R:R:F45	R:R:M289	27.2143	6.22	Yes	No	0	7	6
7	R:R:H261	R:R:I265	31.3523	9.28	Yes	No	1	5	3
8	L:L:F11	R:R:I265	35.6254	3.77	Yes	No	1	0	3
9	L:L:F11	R:R:I189	43.0291	3.77	Yes	Yes	1	0	6
10	R:R:I189	R:R:L262	31.6903	7.14	Yes	No	0	6	5
11	R:R:F258	R:R:L262	31.5078	6.09	Yes	No	0	5	5
12	R:R:F258	R:R:I288	100	5.02	Yes	No	0	5	6
13	R:R:I288	R:R:W255	98.5869	8.22	No	Yes	6	6	8
14	R:R:N291	R:R:W255	51.4064	14.69	No	Yes	0	9	8
15	R:R:D295	R:R:N291	49.9053	12.12	No	No	0	9	9
16	R:R:D295	R:R:D84	22.407	9.31	No	No	0	9	9
17	R:R:D84	R:R:N56	15.7539	8.08	No	No	0	9	9
18	R:R:N56	R:R:P296	12.3462	9.77	No	No	0	9	9
19	R:R:E55	R:R:P296	10.622	4.72	No	No	0	7	9
20	R:R:M289	R:R:N91	30.764	8.41	No	No	0	6	6
21	R:R:I124	R:R:N91	32.2312	11.33	Yes	No	0	4	6
22	R:R:I124	R:R:S90	51.5416	4.64	Yes	No	0	4	5
23	R:R:S90	R:R:V89	48.4314	1.62	No	No	0	5	5
24	R:R:L53	R:R:V89	46.883	5.96	No	No	0	6	5
25	R:R:I57	R:R:L53	43.7728	4.28	No	No	0	4	6
26	R:R:I57	R:R:L61	42.211	1.43	No	No	0	4	5
27	R:R:I60	R:R:L61	40.6626	1.43	No	No	0	8	5
28	R:R:C78	R:R:I60	39.1143	1.64	No	No	0	7	8
29	R:R:C78	R:R:V63	37.762	5.12	No	No	0	7	8
30	R:R:L306	R:R:V63	36.9236	4.47	No	No	0	8	8
31	R:R:L306	R:R:Y74	33.4077	8.21	No	Yes	2	8	8
32	R:R:L77	R:R:Y74	12.4476	3.52	No	Yes	0	8	8
33	R:R:A300	R:R:L77	10.4057	3.15	No	No	0	8	8
34	R:R:L69	R:R:Y74	20.4124	9.38	Yes	Yes	2	8	8
35	R:R:L69	R:R:N66	16.545	9.61	Yes	No	0	8	7
36	R:R:N66	R:R:T309	10.4395	10.24	No	No	0	7	8
37	R:R:S71	R:R:Y74	23.259	3.82	No	Yes	2	7	8
38	R:R:P72	R:R:S71	23.3874	3.56	Yes	No	0	6	7
39	R:R:D295	R:R:L135	40.4395	8.14	No	No	0	9	8
40	R:R:L135	R:R:L80	37.6065	5.54	No	No	0	8	9
41	R:R:L80	R:R:N134	36.3827	4.12	No	No	0	9	8
42	R:R:N134	R:R:S79	33.9216	10.43	No	No	0	8	9
43	R:R:I165	R:R:S79	32.6842	4.64	No	No	0	7	9
44	R:R:F76	R:R:I165	31.4604	5.02	No	No	0	7	7
45	R:R:D141	R:R:F76	28.9993	5.97	Yes	No	0	9	7
46	R:R:D141	R:R:M156	20.5409	4.16	Yes	No	4	9	8
47	R:R:M156	R:R:P72	21.5619	5.03	No	Yes	0	8	6
48	R:R:I132	R:R:W255	43.1711	8.22	No	Yes	0	7	8
49	R:R:I132	R:R:M199	41.6024	5.83	No	No	0	7	7
50	R:R:C133	R:R:M199	16.545	3.24	No	No	0	5	7
51	R:R:C133	R:R:C172	14.76	3.64	No	No	0	5	8
52	L:L:M3	R:R:I98	10.6153	8.75	Yes	No	0	0	4
53	L:L:M3	R:R:I113	33.4483	7.29	Yes	Yes	0	0	8
54	R:R:I113	R:R:M116	22.7721	2.92	Yes	No	0	8	5
55	R:R:M116	R:R:M97	13.4686	5.78	No	No	0	5	4
56	L:L:M3	R:R:D117	35.6254	9.7	Yes	Yes	0	0	3
57	R:R:E94	R:R:I124	14.6586	4.1	Yes	Yes	0	5	4
58	L:L:W8	R:R:I189	23.0291	4.7	Yes	Yes	1	0	6
59	L:L:W8	R:R:I180	26.8492	4.7	Yes	Yes	1	0	5
60	R:R:D121	R:R:I180	32.2042	4.2	Yes	Yes	1	4	5
61	L:L:F6	L:L:W8	36.8965	5.01	Yes	Yes	0	0	0
62	L:L:F6	R:R:D121	45.5781	3.58	Yes	Yes	0	0	4
63	L:L:F6	R:R:I124	49.6349	12.56	Yes	Yes	0	0	4
64	R:R:D117	R:R:D121	30.6018	5.32	Yes	Yes	1	3	4
65	R:R:I180	R:R:S122	12.8668	4.64	Yes	No	0	5	4
66	R:R:C125	R:R:I180	34.7735	3.27	No	Yes	0	4	5
67	R:R:C125	R:R:F179	28.5531	4.19	No	Yes	0	4	3
68	R:R:F251	R:R:W255	48.4246	5.01	No	Yes	0	8	8
69	R:R:F251	R:R:M203	47.3969	11.2	No	No	0	8	8
70	R:R:M203	R:R:Y207	46.7478	5.99	No	Yes	0	8	9
71	R:R:Y207	R:R:Y299	19.5673	3.97	Yes	Yes	3	9	9
72	R:R:L135	R:R:Y299	21.9946	4.69	No	Yes	0	8	9
73	R:R:L136	R:R:M199	25.1724	4.24	No	No	0	7	7
74	R:R:L136	R:R:L202	23.455	6.92	No	No	0	7	5
75	R:R:L202	R:R:L206	21.7241	2.77	No	Yes	0	5	6
76	R:R:L206	R:R:Y143	16.4503	5.86	Yes	No	0	6	8
77	R:R:F147	R:R:Y143	12.8195	18.57	Yes	No	7	6	8
78	R:R:L248	R:R:Y207	35.835	3.52	Yes	Yes	0	7	9
79	R:R:I244	R:R:L248	31.0615	2.85	Yes	Yes	0	7	7
80	R:R:F211	R:R:I244	24.4692	3.77	No	Yes	0	6	7
81	R:R:F211	R:R:G240	21.0886	3.01	No	No	0	6	8
82	R:R:G240	R:R:K239	17.789	1.74	No	No	0	8	8
83	R:R:K239	R:R:Q234	16.0581	4.07	No	No	0	8	4
84	R:R:M238	R:R:Q234	14.3137	8.16	No	No	0	4	4
85	R:R:H235	R:R:M238	10.7843	1.31	No	No	0	4	4
86	R:R:I298	R:R:Y299	14.618	6.04	Yes	Yes	3	9	9
87	R:R:Y277	R:R:Y284	20.7505	18.86	No	Yes	0	1	5
88	R:R:L264	R:R:Y277	16.7072	3.52	No	No	0	5	1
89	R:R:C268	R:R:L264	10.4733	4.76	Yes	No	8	4	5
90	R:R:K186	R:R:M187	11.9811	2.88	No	No	0	4	5
91	L:L:F6	R:R:F258	79.3847	4.29	Yes	Yes	0	0	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:D9	R:R:Q37	6.53	0	No	No	0	3	0	1
R:R:F45	R:R:I40	5.02	5	Yes	No	7	5	1	2
R:R:F45	R:R:T95	9.08	5	Yes	Yes	7	5	1	1
R:R:F45	R:R:L285	3.65	5	Yes	No	7	3	1	2
R:R:F45	R:R:M289	6.22	5	Yes	No	7	6	1	2
L:L:H5	R:R:F45	18.1	5	No	Yes	0	7	0	1
R:R:L46	R:R:T95	4.42	0	No	Yes	5	5	2	1
R:R:I124	R:R:S90	4.64	0	Yes	No	4	5	1	2
R:R:I124	R:R:N91	11.33	0	Yes	No	4	6	1	2
R:R:M289	R:R:N91	8.41	0	No	No	6	6	2	2
R:R:D117	R:R:E94	6.5	1	Yes	Yes	3	5	1	2
R:R:D121	R:R:E94	9.09	1	Yes	Yes	4	5	1	2
R:R:E94	R:R:I124	4.1	1	Yes	Yes	5	4	2	1
I:I:?1	R:R:E94	7.31	1	No	Yes	0	5	2	2
L:L:H5	R:R:T95	6.85	5	No	Yes	0	5	0	1
L:L:M3	R:R:I98	8.75	0	Yes	No	0	4	0	1
L:L:H5	R:R:I98	5.3	5	No	No	0	4	0	1
L:L:Y1	R:R:I113	3.63	0	No	Yes	0	8	0	1
L:L:M3	R:R:I113	7.29	0	Yes	Yes	0	8	0	1
L:L:Y1	R:R:Q114	11.27	0	No	No	0	5	0	1
R:R:D117	R:R:D121	5.32	1	Yes	Yes	3	4	1	1
L:L:M3	R:R:D117	9.7	0	Yes	Yes	0	3	0	1
I:I:?1	R:R:D117	7.49	1	No	Yes	0	3	2	1
R:R:I180	R:R:N118	4.25	1	Yes	No	5	4	1	1
L:L:R7	R:R:N118	6.03	1	Yes	No	0	4	0	1
R:R:D121	R:R:I180	4.2	1	Yes	Yes	4	5	1	1
L:L:F6	R:R:D121	3.58	0	Yes	Yes	0	4	0	1
L:L:R7	R:R:D121	11.91	1	Yes	Yes	0	4	0	1
I:I:?1	R:R:D121	9.98	1	No	Yes	0	4	2	1
R:R:I180	R:R:S122	4.64	1	Yes	No	5	4	1	2
L:L:F6	R:R:I124	12.56	0	Yes	Yes	0	4	0	1
L:L:R7	R:R:I180	8.77	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:I180	4.7	1	Yes	Yes	0	5	0	1
L:L:W8	R:R:S183	11.12	1	Yes	No	0	5	0	1
R:R:I266	R:R:K186	8.72	1	No	No	3	4	1	1
L:L:F11	R:R:K186	6.2	1	Yes	No	0	4	0	1
R:R:I189	R:R:L262	7.14	1	Yes	No	6	5	1	2
R:R:I189	R:R:I266	10.3	1	Yes	No	6	3	1	1
L:L:W8	R:R:I189	4.7	1	Yes	Yes	0	6	0	1
L:L:F11	R:R:I189	3.77	1	Yes	Yes	0	6	0	1
R:R:F258	R:R:F259	10.72	0	Yes	No	5	6	1	2
R:R:F258	R:R:L262	6.09	0	Yes	No	5	5	1	2
R:R:F258	R:R:I288	5.02	0	Yes	No	5	6	1	2
L:L:F6	R:R:F258	4.29	0	Yes	Yes	0	5	0	1
R:R:H261	R:R:I265	9.28	1	Yes	No	5	3	2	1
R:R:H261	R:R:T278	5.48	1	Yes	No	5	3	2	2
R:R:F281	R:R:H261	14.71	0	No	Yes	3	5	1	2
R:R:I265	R:R:T278	4.56	1	No	No	3	3	1	2
L:L:F11	R:R:I265	3.77	1	Yes	No	0	3	0	1
L:L:F11	R:R:I266	3.77	1	Yes	No	0	3	0	1
R:R:F281	R:R:L285	6.09	0	No	No	3	3	1	2
L:L:D9	R:R:F281	17.91	0	No	No	0	3	0	1
R:R:C125	R:R:I180	3.27	0	No	Yes	4	5	2	1
R:R:I113	R:R:M116	2.92	0	Yes	No	8	5	1	2
R:R:K186	R:R:M187	2.88	1	No	No	4	5	1	2
R:R:E184	R:R:S183	2.87	0	No	No	4	5	2	1
R:R:F45	R:R:V286	2.62	5	Yes	No	7	5	1	2
R:R:Q111	R:R:Q114	2.56	0	No	No	2	5	2	1
R:R:P42	R:R:T95	1.75	0	No	Yes	4	5	2	1
R:R:D110	R:R:I113	1.4	0	No	Yes	6	8	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IOC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.42
Number of Linked Nodes	255
Number of Links	281
Number of Hubs	33
Number of Links mediated by Hubs	131
Number of Communities	8
Number of Nodes involved in Communities	44
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	38958
Length Of Smallest Path	3
Average Path Length	13.6851
Length of Longest Path	31
Minimum Path Strength	1.35
Average Path Strength	6.12258
Maximum Path Strength	17.685
Minimum Path Correlation	0.7
Average Path Correlation	0.936258
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.8441
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1202
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • identical protein binding • host cell surface binding • host cell surface receptor binding • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • melanocyte-stimulating hormone receptor activity • viral process • fusion of virus membrane with host endosome membrane • membrane fusion involved in viral entry into host cell • membrane organization • cellular component organization • membrane fusion • fusion of virus membrane with host plasma membrane • cellular component organization or biogenesis • virion attachment to host cell • biological process involved in interspecies interaction between organisms • adhesion of symbiont to host cell • viral life cycle • adhesion of symbiont to host • biological process involved in interaction with host • biological process involved in symbiotic interaction • non-lytic viral release • viral budding • virion assembly • exit from host cell • viral budding from plasma membrane • viral release from host cell • import into cell • receptor-mediated endocytosis of virus by host cell • transport • establishment of localization • vesicle-mediated transport • localization • symbiont entry into host cell • clathrin-dependent endocytosis • symbiont entry into host • clathrin-dependent endocytosis of virus by host cell • receptor-mediated endocytosis • endocytosis • endocytosis involved in viral entry into host cell • heart process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • metabolic process • regulation of metabolic process • regulation of blood pressure • behavior • rhythmic process • circadian behavior • locomotory behavior • rhythmic behavior • circadian rhythm • locomotor rhythm • multicellular organismal-level homeostasis • homoiothermy • homeostatic process • temperature homeostasis • sodium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • regulation of biosynthetic process • circadian regulation of gene expression • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • virion component • virion membrane • viral membrane • viral envelope • host cell plasma membrane • host cellular component • host cell part • host cell membrane • G-protein beta-subunit binding • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • molecular function activator activity • signaling receptor activator activity • hormone activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • neuropeptide signaling pathway • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • tumor necrosis factor production • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • negative regulation of multicellular organismal process • regulation of localization • corticosterone secretion • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • endocrine process • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • calcium-mediated signaling • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to peptide hormone • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • glucose homeostasis • carbohydrate homeostasis • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle lumen • cytoplasmic vesicle lumen • secretory granule lumen
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>8IOC_nogp_Chain_R C E Q V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L P P Q H S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F R E I Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	10.2210/pdb8KIG/pdb

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Download 8IOC_nogp.zip

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