psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C276	R:R:C35	7.28	No	No	0	4	4
2	R:R:N282	R:R:Q37	9.24	No	No	0	3	3
3	R:R:N282	R:R:V38	5.91	No	No	0	3	2
4	R:R:F45	R:R:I40	5.02	Yes	No	0	7	5
5	R:R:I40	R:R:N282	8.5	No	No	0	5	3
6	R:R:E43	R:R:K41	8.1	No	No	0	3	4
7	R:R:K41	R:R:V44	3.04	No	No	0	4	4
8	R:R:P42	R:R:T95	3.5	No	No	0	4	5
9	R:R:F45	R:R:V44	2.62	Yes	No	0	7	4
10	R:R:F45	R:R:T95	9.08	Yes	No	0	7	5
11	R:R:F45	R:R:M289	4.98	Yes	Yes	0	7	6
12	R:R:L48	R:R:S47	4.5	Yes	No	0	6	3
13	R:R:L48	R:R:M289	5.65	Yes	Yes	0	6	6
14	R:R:E55	R:R:V51	2.85	No	No	0	7	5
15	R:R:V293	R:R:V51	3.21	No	No	0	5	5
16	R:R:S52	R:R:S88	6.52	No	No	6	7	8
17	R:R:L53	R:R:M85	4.24	No	No	0	6	6
18	R:R:L53	R:R:V89	4.47	No	No	0	6	5
19	R:R:L54	R:R:L58	4.15	No	No	0	4	7
20	R:R:E55	R:R:P296	6.29	No	No	0	7	9
21	R:R:E55	R:R:F301	3.5	No	Yes	0	7	6
22	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
23	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
24	R:R:M85	R:R:N56	4.21	No	Yes	0	6	9
25	R:R:N56	R:R:P296	13.03	Yes	No	0	9	9
26	R:R:I57	R:R:M85	5.83	No	No	0	4	6
27	R:R:A300	R:R:V59	3.39	No	No	0	8	9
28	R:R:F301	R:R:V59	3.93	Yes	No	0	6	9
29	R:R:C78	R:R:I60	4.91	No	No	0	7	8
30	R:R:L61	R:R:R65	4.86	No	No	0	5	5
31	R:R:A62	R:R:L306	3.15	No	Yes	0	8	8
32	R:R:A62	R:R:T309	3.36	No	No	0	8	8
33	R:R:V63	R:R:Y74	2.52	Yes	Yes	0	8	8
34	R:R:C78	R:R:V63	5.12	No	Yes	0	7	8
35	R:R:N66	R:R:N68	5.45	No	No	3	7	7
36	R:R:L69	R:R:N66	6.87	Yes	No	3	8	7
37	R:R:N66	R:R:T309	11.7	No	No	0	7	8
38	R:R:G67	R:R:H70	7.94	No	No	0	5	8
39	R:R:L69	R:R:N68	5.49	Yes	No	3	8	7
40	R:R:L69	R:R:Y74	17.58	Yes	Yes	3	8	8
41	R:R:E305	R:R:L69	3.98	No	Yes	3	6	8
42	R:R:L306	R:R:L69	4.15	Yes	Yes	3	8	8
43	R:R:F75	R:R:H70	5.66	Yes	No	0	4	8
44	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
45	R:R:S71	R:R:Y74	2.54	No	Yes	0	7	8
46	R:R:F76	R:R:P72	2.89	Yes	Yes	2	7	6
47	R:R:M156	R:R:P72	6.71	No	Yes	2	8	6
48	R:R:A161	R:R:P72	3.74	No	Yes	2	6	6
49	R:R:M73	R:R:Y74	5.99	No	Yes	0	8	8
50	R:R:D141	R:R:M73	2.77	No	No	0	9	8
51	R:R:L77	R:R:Y74	2.34	No	Yes	0	8	8
52	R:R:S303	R:R:Y74	7.63	No	Yes	3	8	8
53	R:R:E305	R:R:Y74	11.22	No	Yes	3	6	8
54	R:R:L306	R:R:Y74	5.86	Yes	Yes	3	8	8
55	R:R:F75	R:R:V158	3.93	Yes	No	0	4	1
56	R:R:F75	R:R:L162	3.65	Yes	No	0	4	2
57	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
58	R:R:F76	R:R:M156	2.49	Yes	No	2	7	8
59	R:R:A161	R:R:F76	2.77	No	Yes	2	6	7
60	R:R:F76	R:R:L164	3.65	Yes	No	0	7	6
61	R:R:F76	R:R:I165	3.77	Yes	No	2	7	7
62	R:R:I138	R:R:L77	2.85	Yes	No	0	8	8
63	R:R:A300	R:R:L77	4.73	No	No	0	8	8
64	R:R:N134	R:R:S79	10.43	No	No	2	8	9
65	R:R:I165	R:R:S79	6.19	No	No	2	7	9
66	R:R:S79	R:R:W169	6.18	No	Yes	2	9	9
67	R:R:D84	R:R:L80	8.14	Yes	Yes	0	9	9
68	R:R:L80	R:R:N134	6.87	Yes	No	2	9	8
69	R:R:L135	R:R:L80	5.54	Yes	Yes	2	8	9
70	R:R:I138	R:R:L80	2.85	Yes	Yes	2	8	9
71	R:R:L80	R:R:Y299	2.34	Yes	Yes	2	9	9
72	R:R:V82	R:R:W169	4.9	No	Yes	0	7	9
73	R:R:A83	R:R:W169	2.59	No	Yes	0	8	9
74	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
75	R:R:D84	R:R:S292	10.31	Yes	No	0	9	9
76	R:R:D295	R:R:D84	7.98	No	Yes	0	9	9
77	R:R:L86	R:R:S127	4.5	No	No	0	6	7
78	R:R:L86	R:R:W169	2.28	No	Yes	0	6	9
79	R:R:S127	R:R:V87	6.46	No	No	0	7	8
80	R:R:M123	R:R:S90	10.73	No	No	0	4	5
81	R:R:I124	R:R:S90	7.74	No	No	0	4	5
82	R:R:I124	R:R:N91	7.08	No	No	0	4	6
83	R:R:L285	R:R:N91	8.24	Yes	No	1	3	6
84	R:R:M289	R:R:N91	5.61	Yes	No	1	6	6
85	R:R:F120	R:R:L93	6.09	Yes	No	0	5	6
86	R:R:E94	R:R:T95	8.47	No	No	0	5	5
87	R:R:E94	R:R:I98	4.1	No	No	0	5	4
88	R:R:E94	R:R:F120	3.5	No	Yes	0	5	5
89	R:R:F120	R:R:M97	3.73	Yes	No	0	5	4
90	R:R:I113	R:R:V101	3.07	No	No	0	8	3
91	R:R:S103	R:R:Y105	13.99	No	No	0	4	3
92	R:R:E109	R:R:Q111	3.82	No	No	7	3	2
93	R:R:E109	R:R:F112	5.83	No	No	7	3	1
94	R:R:F112	R:R:Q111	2.34	No	No	7	1	2
95	R:R:D117	R:R:Q114	2.61	No	No	0	3	5
96	R:R:I119	R:R:M116	2.92	No	No	0	5	5
97	R:R:F120	R:R:M116	7.46	Yes	No	0	5	5
98	R:R:I119	R:R:N118	9.91	No	No	0	5	4
99	R:R:F120	R:R:M123	2.49	Yes	No	0	5	4
100	R:R:D121	R:R:I124	4.2	No	No	0	4	4
101	R:R:D121	R:R:F179	9.55	No	Yes	0	4	3
102	R:R:F179	R:R:S122	5.28	Yes	No	8	3	4
103	R:R:I180	R:R:S122	3.1	No	No	8	5	4
104	R:R:C125	R:R:F179	8.38	No	Yes	0	4	3
105	R:R:G173	R:R:I126	5.29	No	No	0	4	4
106	R:R:G176	R:R:I126	3.53	No	No	0	6	4
107	R:R:L128	R:R:W255	6.83	No	Yes	0	5	8
108	R:R:C172	R:R:V129	6.83	No	No	0	8	5
109	R:R:M195	R:R:V129	3.04	No	No	0	4	5
110	R:R:A130	R:R:W169	5.19	No	Yes	0	7	9
111	R:R:A130	R:R:C172	3.61	No	No	0	7	8
112	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
113	R:R:F196	R:R:I132	3.77	Yes	No	1	7	7
114	R:R:I132	R:R:M199	2.92	No	Yes	0	7	7
115	R:R:I132	R:R:W255	8.22	No	Yes	1	7	8
116	R:R:C133	R:R:I168	3.27	No	No	0	5	6
117	R:R:C133	R:R:C172	3.64	No	No	0	5	8
118	R:R:C133	R:R:M199	3.24	No	Yes	0	5	7
119	R:R:N134	R:R:W169	3.39	No	Yes	2	8	9
120	R:R:L135	R:R:M203	2.83	Yes	Yes	2	8	8
121	R:R:F251	R:R:L135	3.65	No	Yes	2	8	8
122	R:R:L135	R:R:Y299	10.55	Yes	Yes	2	8	9
123	R:R:L136	R:R:M199	7.07	No	Yes	0	7	7
124	R:R:L136	R:R:L202	6.92	No	No	0	7	5
125	R:R:L136	R:R:M203	4.24	No	Yes	0	7	8
126	R:R:I138	R:R:R142	7.52	Yes	No	0	8	9
127	R:R:I138	R:R:Y299	9.67	Yes	Yes	2	8	9
128	R:R:A139	R:R:M203	3.22	No	Yes	2	8	8
129	R:R:A139	R:R:Y207	2.67	No	Yes	2	8	9
130	R:R:L206	R:R:V140	2.98	No	No	0	6	6
131	R:R:D141	R:R:Y152	5.75	No	Yes	0	9	8
132	R:R:R142	R:R:Y207	7.2	No	Yes	0	9	9
133	R:R:M210	R:R:R142	2.48	No	No	0	9	9
134	R:R:F147	R:R:Y143	27.85	Yes	Yes	4	6	8
135	R:R:L206	R:R:Y143	11.72	No	Yes	0	6	8
136	R:R:H209	R:R:Y143	9.8	No	Yes	4	6	8
137	R:R:M210	R:R:Y143	3.59	No	Yes	4	9	8
138	R:R:V144	R:R:Y148	2.52	No	No	0	6	5
139	R:R:V144	R:R:Y152	5.05	No	Yes	0	6	8
140	R:R:T145	R:R:Y152	8.74	No	Yes	0	8	8
141	R:R:F147	R:R:I146	8.79	Yes	No	4	6	9
142	R:R:F213	R:R:I146	2.51	Yes	No	4	5	9
143	R:R:F147	R:R:H209	9.05	Yes	No	4	6	6
144	R:R:F147	R:R:M210	2.49	Yes	No	4	6	9
145	R:R:F147	R:R:F213	6.43	Yes	Yes	4	6	5
146	R:R:R151	R:R:S154	7.91	No	No	0	6	5
147	R:R:I155	R:R:R151	2.51	No	No	0	5	6
148	R:R:M156	R:R:Y152	16.76	No	Yes	0	8	8
149	R:R:K160	R:R:T157	4.5	No	No	0	7	8
150	R:R:I165	R:R:W169	2.35	No	Yes	2	7	9
151	R:R:F179	R:R:I180	3.77	Yes	No	8	3	5
152	R:R:E184	R:R:F179	15.16	No	Yes	0	4	3
153	R:R:S185	R:R:Y182	7.63	No	No	0	4	5
154	R:R:M187	R:R:Y182	2.39	No	No	0	5	5
155	R:R:E184	R:R:S183	4.31	No	No	0	4	5
156	R:R:E184	R:R:V188	2.85	No	No	0	4	5
157	R:R:K186	R:R:M187	2.88	No	No	0	4	5
158	R:R:I189	R:R:I193	2.94	No	No	1	6	4
159	R:R:I189	R:R:L262	7.14	No	No	1	6	5
160	R:R:I189	R:R:I266	17.66	No	Yes	1	6	3
161	R:R:F259	R:R:L192	7.31	Yes	No	0	6	4
162	R:R:I193	R:R:L262	2.85	No	No	1	4	5
163	R:R:I193	R:R:V263	7.68	No	No	0	4	5
164	R:R:M195	R:R:M199	4.33	No	Yes	0	4	7
165	R:R:F196	R:R:F197	5.36	Yes	No	0	7	4
166	R:R:F196	R:R:W255	11.02	Yes	Yes	1	7	8
167	R:R:F196	R:R:F259	33.22	Yes	Yes	1	7	6
168	R:R:F251	R:R:M200	2.49	No	No	0	8	6
169	R:R:I252	R:R:M200	7.29	No	No	0	5	6
170	R:R:L202	R:R:L206	4.15	No	No	0	5	6
171	R:R:M203	R:R:Y207	2.39	Yes	Yes	2	8	9
172	R:R:F251	R:R:M203	9.95	No	Yes	2	8	8
173	R:R:G204	R:R:L248	5.13	No	No	0	5	7
174	R:R:I244	R:R:Y207	2.42	Yes	Yes	0	7	9
175	R:R:L247	R:R:Y207	4.69	Yes	Yes	2	8	9
176	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
177	R:R:F211	R:R:L212	2.44	Yes	No	5	6	3
178	R:R:F211	R:R:R215	7.48	Yes	No	5	6	6
179	R:R:C237	R:R:F211	2.79	No	Yes	5	6	6
180	R:R:F211	R:R:G240	3.01	Yes	No	0	6	8
181	R:R:A241	R:R:F211	2.77	No	Yes	0	7	6
182	R:R:L212	R:R:R215	2.43	No	No	5	3	6
183	R:R:F213	R:R:H217	9.05	Yes	No	0	5	7
184	R:R:C237	R:R:R215	11.14	No	No	5	6	6
185	R:R:H217	R:R:R220	3.39	No	No	0	7	6
186	R:R:I246	R:R:V242	3.07	No	No	0	7	7
187	R:R:L247	R:R:T243	2.95	Yes	No	0	8	9
188	R:R:I244	R:R:L248	2.85	Yes	No	0	7	7
189	R:R:I246	R:R:I298	2.94	No	Yes	0	7	9
190	R:R:I298	R:R:L247	5.71	Yes	Yes	2	9	8
191	R:R:L247	R:R:Y299	2.34	Yes	Yes	2	8	9
192	R:R:I294	R:R:V250	4.61	No	No	2	6	6
193	R:R:I298	R:R:V250	4.61	Yes	No	2	9	6
194	R:R:C254	R:R:N291	4.72	No	No	0	8	9
195	R:R:F259	R:R:W255	3.01	Yes	Yes	1	6	8
196	R:R:I288	R:R:W255	4.7	No	Yes	0	6	8
197	R:R:N291	R:R:W255	13.56	No	Yes	0	9	8
198	R:R:P257	R:R:Y284	2.78	No	Yes	0	9	5
199	R:R:L287	R:R:P257	3.28	No	No	0	7	9
200	R:R:F258	R:R:F281	3.22	No	No	1	5	3
201	R:R:F258	R:R:L285	2.44	No	Yes	1	5	3
202	R:R:L260	R:R:L264	6.92	No	No	1	5	5
203	R:R:L260	R:R:Y277	10.55	No	No	1	5	1
204	R:R:H261	R:R:I265	14.58	Yes	No	1	5	3
205	R:R:H261	R:R:T278	8.21	Yes	No	1	5	3
206	R:R:F281	R:R:H261	9.05	No	Yes	1	3	5
207	R:R:H261	R:R:Y284	6.53	Yes	Yes	1	5	5
208	R:R:I266	R:R:L262	2.85	Yes	No	1	3	5
209	R:R:C268	R:R:L264	4.76	No	No	0	4	5
210	R:R:L264	R:R:Y277	8.21	No	No	1	5	1
211	R:R:I265	R:R:I266	4.42	No	Yes	1	3	3
212	R:R:I265	R:R:T278	4.56	No	No	1	3	3
213	R:R:C268	R:R:C274	7.28	No	No	0	4	4
214	R:R:N271	R:R:P272	6.52	No	No	0	4	1
215	R:R:N271	R:R:Y273	9.3	No	No	0	4	3
216	R:R:C274	R:R:N271	6.3	No	No	0	4	4
217	R:R:I275	R:R:T278	3.04	No	No	0	1	3
218	R:R:Y277	R:R:Y284	11.91	No	Yes	1	1	5
219	R:R:A279	R:R:H280	2.93	No	No	0	3	3
220	R:R:H280	R:R:T283	6.85	No	No	1	3	4
221	R:R:H280	R:R:Y284	3.27	No	Yes	1	3	5
222	R:R:F281	R:R:L285	9.74	No	Yes	1	3	3
223	R:R:T283	R:R:Y284	3.75	No	Yes	1	4	5
224	R:R:L285	R:R:M289	2.83	Yes	Yes	1	3	6
225	R:R:D295	R:R:N291	14.81	No	No	0	9	9
226	R:R:I294	R:R:I298	4.42	No	Yes	2	6	9
227	R:R:D295	R:R:P296	3.22	No	No	0	9	9
228	R:R:F301	R:R:L297	2.44	Yes	No	0	6	5
229	R:R:I298	R:R:Y299	2.42	Yes	Yes	2	9	9
230	R:R:A300	R:R:L306	3.15	No	Yes	0	8	8
231	R:R:F301	R:R:L306	2.44	Yes	Yes	0	6	8
232	R:R:F301	R:R:F310	4.29	Yes	No	0	6	7
233	R:R:R302	R:R:R307	4.26	No	No	0	8	8
234	R:R:E305	R:R:S303	5.75	No	No	3	6	8
235	R:R:L306	R:R:S303	3	Yes	No	3	8	8
236	R:R:L304	R:R:R307	2.43	No	No	0	5	8
237	R:R:L304	R:R:N308	2.75	No	No	0	5	4
238	R:R:F310	R:R:R307	3.21	No	No	0	7	8
239	R:R:F112	R:R:H115	2.26	No	No	0	1	4
240	R:R:F258	R:R:F259	2.14	No	Yes	1	5	6
241	R:R:C125	R:R:G176	1.96	No	No	0	4	6
242	R:R:P225	R:R:P226	1.95	No	No	0	3	3
243	R:R:C268	R:R:P269	1.88	No	No	0	4	2
244	R:R:A256	R:R:P257	1.87	No	No	0	5	9
245	R:R:G49	R:R:S52	1.86	No	No	6	6	7
246	R:R:G49	R:R:S88	1.86	No	No	6	6	8
247	R:R:G249	R:R:I252	1.76	No	No	0	6	5
248	R:R:P269	R:R:T270	1.75	No	No	0	2	1
249	R:R:G49	R:R:L48	1.71	No	Yes	0	6	6
250	R:R:C175	R:R:V174	1.71	No	No	0	4	3
251	R:R:C290	R:R:V286	1.71	No	No	0	5	5
252	R:R:L224	R:R:P225	1.64	No	No	0	5	3
253	R:R:V63	R:R:V64	1.6	Yes	No	0	8	4
254	R:R:V166	R:R:V170	1.6	No	No	0	5	4
255	R:R:V170	R:R:V174	1.6	No	No	0	4	3
256	R:R:V177	R:R:V181	1.6	No	No	0	4	2
257	R:R:C290	R:R:L48	1.59	No	Yes	0	5	6
258	R:R:T194	R:R:V190	1.59	No	No	0	4	4
259	R:R:T267	R:R:V263	1.59	No	No	0	4	5
260	R:R:I180	R:R:V181	1.54	No	No	0	5	2
261	R:R:M97	R:R:V101	1.52	No	No	0	4	3
262	R:R:M238	R:R:V242	1.52	No	No	0	4	7
263	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
264	R:R:L61	R:R:V64	1.49	No	No	0	5	4
265	R:R:L212	R:R:V208	1.49	No	No	0	3	3
266	R:R:I100	R:R:I96	1.47	No	No	0	3	5
267	R:R:I155	R:R:K160	1.45	No	No	0	5	7
268	R:R:I266	R:R:K186	1.45	Yes	No	0	3	4
269	R:R:I96	R:R:L46	1.43	No	No	0	5	5
270	R:R:L201	R:R:M200	1.41	No	No	0	4	6
271	R:R:D110	R:R:I113	1.4	No	No	0	6	8
272	R:R:D117	R:R:M97	1.39	No	No	0	3	4
273	R:R:F75	R:R:V63	1.31	Yes	Yes	0	4	8
274	R:R:R159	R:R:T157	1.29	No	No	0	4	8
275	R:R:H115	R:R:N118	1.28	No	No	0	4	4
276	R:R:V178	R:R:Y182	1.26	No	No	0	4	5
277	R:R:F253	R:R:I252	1.26	No	No	0	5	5
278	R:R:F213	R:R:L216	1.22	Yes	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F45	5.425	4	0	7
2	R:R:L48	3.3625	4	0	6
3	R:R:N56	7.165	4	0	9
4	R:R:V63	2.6375	4	0	8
5	R:R:L69	7.614	5	3	8
6	R:R:P72	4.225	4	2	6
7	R:R:Y74	6.96	8	3	8
8	R:R:F75	3.6375	4	0	4
9	R:R:F76	3.28833	6	2	7
10	R:R:L80	5.148	5	2	9
11	R:R:D84	7.516	5	0	9
12	R:R:F120	4.654	5	0	5
13	R:R:L135	5.6425	4	2	8
14	R:R:I138	5.7225	4	2	8
15	R:R:Y143	13.24	4	4	8
16	R:R:F147	10.922	5	4	6
17	R:R:Y152	9.075	4	0	8
18	R:R:W169	3.84	7	2	9
19	R:R:F179	8.428	5	8	3
20	R:R:F196	13.3425	4	1	7
21	R:R:M199	4.39	4	0	7
22	R:R:M203	4.526	5	2	8
23	R:R:Y207	3.874	5	2	9
24	R:R:F211	3.698	5	5	6
25	R:R:F213	4.8025	4	4	5
26	R:R:I244	2.465	4	0	7
27	R:R:L247	3.9225	4	2	8
28	R:R:W255	7.46857	7	1	8
29	R:R:F259	11.42	4	1	6
30	R:R:H261	9.5925	4	1	5
31	R:R:I266	6.595	4	1	3
32	R:R:Y284	5.648	5	1	5
33	R:R:L285	5.8125	4	1	3
34	R:R:M289	4.7675	4	1	6
35	R:R:I298	4.02	5	2	9
36	R:R:Y299	5.464	5	2	9
37	R:R:F301	3.32	5	0	6
38	R:R:L306	3.625	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F45	R:R:T95	22.9439	9.08	Yes	No	0	7	5
2	R:R:F45	R:R:M289	32.1573	4.98	Yes	Yes	0	7	6
3	R:R:E55	R:R:P296	16.3872	6.29	No	No	0	7	9
4	R:R:D295	R:R:P296	13.9378	3.22	No	No	0	9	9
5	R:R:D295	R:R:N291	12.9392	14.81	No	No	0	9	9
6	R:R:N291	R:R:W255	12.553	13.56	No	Yes	0	9	8
7	R:R:F259	R:R:W255	79.3453	3.01	Yes	Yes	1	6	8
8	R:R:F258	R:R:F259	100	2.14	No	Yes	1	5	6
9	R:R:F258	R:R:L285	65.073	2.44	No	Yes	1	5	3
10	R:R:L285	R:R:M289	39.4677	2.83	Yes	Yes	1	3	6
11	R:R:D84	R:R:S131	48.926	4.42	Yes	No	0	9	9
12	R:R:S131	R:R:W255	48.6905	4.94	No	Yes	0	9	8
13	R:R:E55	R:R:F301	13.773	3.5	No	Yes	0	7	6
14	R:R:I138	R:R:L77	38.3891	2.85	Yes	No	0	8	8
15	R:R:I138	R:R:L80	31.5827	2.85	Yes	Yes	2	8	9
16	R:R:D84	R:R:L80	55.935	8.14	Yes	Yes	0	9	9
17	R:R:V63	R:R:Y74	14.1922	2.52	Yes	Yes	0	8	8
18	R:R:L77	R:R:Y74	29.6185	2.34	No	Yes	0	8	8
19	R:R:F301	R:R:L306	13.17	2.44	Yes	Yes	0	6	8
20	R:R:L80	R:R:N134	28.5634	6.87	Yes	No	2	9	8
21	R:R:F76	R:R:I165	17.6825	3.77	Yes	No	2	7	7
22	R:R:N134	R:R:W169	17.772	3.39	No	Yes	2	8	9
23	R:R:I165	R:R:W169	10.9374	2.35	No	Yes	2	7	9
24	R:R:L135	R:R:L80	12.8686	5.54	Yes	Yes	2	8	9
25	R:R:F120	R:R:M123	18.3184	2.49	Yes	No	0	5	4
26	R:R:E94	R:R:F120	18.4362	3.5	No	Yes	0	5	5
27	R:R:E94	R:R:T95	20.6171	8.47	No	No	0	5	5
28	R:R:I124	R:R:N91	36.5191	7.08	No	No	0	4	6
29	R:R:I124	R:R:S90	20.6265	7.74	No	No	0	4	5
30	R:R:F120	R:R:M97	14.6491	3.73	Yes	No	0	5	4
31	R:R:I119	R:R:N118	12.4541	9.91	No	No	0	5	4
32	R:R:I119	R:R:M116	14.9176	2.92	No	No	0	5	5
33	R:R:F120	R:R:M116	17.3716	7.46	Yes	No	0	5	5
34	R:R:D121	R:R:I124	17.1408	4.2	No	No	0	4	4
35	R:R:D121	R:R:F179	15.8785	9.55	No	Yes	0	4	3
36	R:R:I132	R:R:M199	42.6849	2.92	No	Yes	0	7	7
37	R:R:F196	R:R:I132	21.1493	3.77	Yes	No	1	7	7
38	R:R:F196	R:R:F259	21.5544	33.22	Yes	Yes	1	7	6
39	R:R:I132	R:R:W255	22.5012	8.22	No	Yes	1	7	8
40	R:R:L136	R:R:M203	28.0122	4.24	No	Yes	0	7	8
41	R:R:L136	R:R:M199	37.9275	7.07	No	Yes	0	7	7
42	R:R:L136	R:R:L202	14.0697	6.92	No	No	0	7	5
43	R:R:I138	R:R:R142	19.8493	7.52	Yes	No	0	8	9
44	R:R:M203	R:R:Y207	19.3311	2.39	Yes	Yes	2	8	9
45	R:R:L202	R:R:L206	11.8935	4.15	No	No	0	5	6
46	R:R:M210	R:R:R142	12.162	2.48	No	No	0	9	9
47	R:R:L206	R:R:Y143	10.2449	11.72	No	Yes	0	6	8
48	R:R:F281	R:R:L285	11.3754	9.74	No	Yes	1	3	3
49	R:R:F281	R:R:H261	44.7292	9.05	No	Yes	1	3	5
50	R:R:H261	R:R:I265	20.3862	14.58	Yes	No	1	5	3
51	R:R:I265	R:R:I266	19.1992	4.42	No	Yes	1	3	3
52	R:R:F251	R:R:M200	13.2077	2.49	No	No	0	8	6
53	R:R:I244	R:R:Y207	25.3038	2.42	Yes	Yes	0	7	9
54	R:R:I244	R:R:V208	16.976	3.07	Yes	No	0	7	3
55	R:R:L212	R:R:V208	14.8705	1.49	No	No	0	3	3
56	R:R:H261	R:R:Y284	23.1795	6.53	Yes	Yes	1	5	5
57	R:R:Y277	R:R:Y284	13.9237	11.91	No	Yes	1	1	5
58	R:R:L264	R:R:Y277	11.2529	8.21	No	No	1	5	1
59	R:R:F301	R:R:F310	10.6171	4.29	Yes	No	0	6	7
60	R:R:M123	R:R:S90	19.4395	10.73	No	No	0	4	5
61	R:R:L285	R:R:N91	36.1564	8.24	Yes	No	1	3	6
62	R:R:R142	R:R:Y207	10.1366	7.2	No	Yes	0	9	9
63	R:R:F258	R:R:F281	34.4512	3.22	No	No	1	5	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K3F_nogp

PDB Summary
PDB	9K3F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.28
Number of Linked Nodes	240
Number of Links	278
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	68
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	40238
Length Of Smallest Path	3
Average Path Length	12.6366
Length of Longest Path	26
Minimum Path Strength	1.45
Average Path Strength	5.37193
Maximum Path Strength	20.265
Minimum Path Correlation	0.7
Average Path Correlation	0.939086
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	58.167
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9705
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • metabolic process • regulation of metabolic process • regulation of blood pressure • phospholipase C-activating G protein-coupled receptor signaling pathway • behavior • rhythmic process • circadian behavior • locomotory behavior • rhythmic behavior • circadian rhythm • locomotor rhythm • multicellular organismal-level homeostasis • homoiothermy • homeostatic process • temperature homeostasis • sodium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • regulation of biosynthetic process • circadian regulation of gene expression • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of cellular process • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • G-protein beta-subunit binding • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>9K3F_nogp_Chain_R C E Q V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L P P S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3F_nogp.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.