psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C276	R:R:C35	7.28	No	No	0	4	4
2	R:R:N282	R:R:Q37	9.24	No	No	0	3	3
3	R:R:N282	R:R:V38	5.91	No	No	0	3	2
4	R:R:F45	R:R:I40	5.02	Yes	No	0	7	5
5	R:R:I40	R:R:N282	8.5	No	No	0	5	3
6	R:R:E43	R:R:K41	8.1	No	No	0	3	4
7	R:R:K41	R:R:V44	3.04	No	No	0	4	4
8	R:R:P42	R:R:T95	3.5	No	No	0	4	5
9	R:R:F45	R:R:V44	2.62	Yes	No	0	7	4
10	R:R:F45	R:R:T95	9.08	Yes	No	0	7	5
11	R:R:F45	R:R:M289	4.98	Yes	Yes	0	7	6
12	R:R:L48	R:R:S47	4.5	Yes	No	0	6	3
13	R:R:L48	R:R:M289	5.65	Yes	Yes	0	6	6
14	R:R:E55	R:R:V51	2.85	No	No	0	7	5
15	R:R:V293	R:R:V51	3.21	No	No	0	5	5
16	R:R:S52	R:R:S88	6.52	No	No	6	7	8
17	R:R:L53	R:R:M85	4.24	No	No	0	6	6
18	R:R:L53	R:R:V89	4.47	No	No	0	6	5
19	R:R:L54	R:R:L58	4.15	No	No	0	4	7
20	R:R:E55	R:R:P296	6.29	No	No	0	7	9
21	R:R:E55	R:R:F301	3.5	No	Yes	0	7	6
22	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
23	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
24	R:R:M85	R:R:N56	4.21	No	Yes	0	6	9
25	R:R:N56	R:R:P296	13.03	Yes	No	0	9	9
26	R:R:I57	R:R:M85	5.83	No	No	0	4	6
27	R:R:A300	R:R:V59	3.39	No	No	0	8	9
28	R:R:F301	R:R:V59	3.93	Yes	No	0	6	9
29	R:R:C78	R:R:I60	4.91	No	No	0	7	8
30	R:R:L61	R:R:R65	4.86	No	No	0	5	5
31	R:R:A62	R:R:L306	3.15	No	Yes	0	8	8
32	R:R:A62	R:R:T309	3.36	No	No	0	8	8
33	R:R:V63	R:R:Y74	2.52	Yes	Yes	0	8	8
34	R:R:C78	R:R:V63	5.12	No	Yes	0	7	8
35	R:R:N66	R:R:N68	5.45	No	No	3	7	7
36	R:R:L69	R:R:N66	6.87	Yes	No	3	8	7
37	R:R:N66	R:R:T309	11.7	No	No	0	7	8
38	R:R:G67	R:R:H70	7.94	No	No	0	5	8
39	R:R:L69	R:R:N68	5.49	Yes	No	3	8	7
40	R:R:L69	R:R:Y74	17.58	Yes	Yes	3	8	8
41	R:R:E305	R:R:L69	3.98	No	Yes	3	6	8
42	R:R:L306	R:R:L69	4.15	Yes	Yes	3	8	8
43	R:R:F75	R:R:H70	5.66	Yes	No	0	4	8
44	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
45	R:R:S71	R:R:Y74	2.54	No	Yes	0	7	8
46	R:R:F76	R:R:P72	2.89	Yes	Yes	2	7	6
47	R:R:M156	R:R:P72	6.71	No	Yes	2	8	6
48	R:R:A161	R:R:P72	3.74	No	Yes	2	6	6
49	R:R:M73	R:R:Y74	5.99	No	Yes	0	8	8
50	R:R:D141	R:R:M73	2.77	No	No	0	9	8
51	R:R:L77	R:R:Y74	2.34	No	Yes	0	8	8
52	R:R:S303	R:R:Y74	7.63	No	Yes	3	8	8
53	R:R:E305	R:R:Y74	11.22	No	Yes	3	6	8
54	R:R:L306	R:R:Y74	5.86	Yes	Yes	3	8	8
55	R:R:F75	R:R:V158	3.93	Yes	No	0	4	1
56	R:R:F75	R:R:L162	3.65	Yes	No	0	4	2
57	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
58	R:R:F76	R:R:M156	2.49	Yes	No	2	7	8
59	R:R:A161	R:R:F76	2.77	No	Yes	2	6	7
60	R:R:F76	R:R:L164	3.65	Yes	No	0	7	6
61	R:R:F76	R:R:I165	3.77	Yes	No	2	7	7
62	R:R:I138	R:R:L77	2.85	Yes	No	0	8	8
63	R:R:A300	R:R:L77	4.73	No	No	0	8	8
64	R:R:N134	R:R:S79	10.43	No	No	2	8	9
65	R:R:I165	R:R:S79	6.19	No	No	2	7	9
66	R:R:S79	R:R:W169	6.18	No	Yes	2	9	9
67	R:R:D84	R:R:L80	8.14	Yes	Yes	0	9	9
68	R:R:L80	R:R:N134	6.87	Yes	No	2	9	8
69	R:R:L135	R:R:L80	5.54	Yes	Yes	2	8	9
70	R:R:I138	R:R:L80	2.85	Yes	Yes	2	8	9
71	R:R:L80	R:R:Y299	2.34	Yes	Yes	2	9	9
72	R:R:V82	R:R:W169	4.9	No	Yes	0	7	9
73	R:R:A83	R:R:W169	2.59	No	Yes	0	8	9
74	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
75	R:R:D84	R:R:S292	10.31	Yes	No	0	9	9
76	R:R:D295	R:R:D84	7.98	No	Yes	0	9	9
77	R:R:L86	R:R:S127	4.5	No	No	0	6	7
78	R:R:L86	R:R:W169	2.28	No	Yes	0	6	9
79	R:R:S127	R:R:V87	6.46	No	No	0	7	8
80	R:R:M123	R:R:S90	10.73	No	No	0	4	5
81	R:R:I124	R:R:S90	7.74	No	No	0	4	5
82	R:R:I124	R:R:N91	7.08	No	No	0	4	6
83	R:R:L285	R:R:N91	8.24	Yes	No	1	3	6
84	R:R:M289	R:R:N91	5.61	Yes	No	1	6	6
85	R:R:F120	R:R:L93	6.09	Yes	No	0	5	6
86	R:R:E94	R:R:T95	8.47	No	No	0	5	5
87	R:R:E94	R:R:I98	4.1	No	No	0	5	4
88	R:R:E94	R:R:F120	3.5	No	Yes	0	5	5
89	R:R:F120	R:R:M97	3.73	Yes	No	0	5	4
90	R:R:I113	R:R:V101	3.07	No	No	0	8	3
91	R:R:S103	R:R:Y105	13.99	No	No	0	4	3
92	R:R:E109	R:R:Q111	3.82	No	No	7	3	2
93	R:R:E109	R:R:F112	5.83	No	No	7	3	1
94	R:R:F112	R:R:Q111	2.34	No	No	7	1	2
95	R:R:D117	R:R:Q114	2.61	No	No	0	3	5
96	R:R:I119	R:R:M116	2.92	No	No	0	5	5
97	R:R:F120	R:R:M116	7.46	Yes	No	0	5	5
98	R:R:I119	R:R:N118	9.91	No	No	0	5	4
99	R:R:F120	R:R:M123	2.49	Yes	No	0	5	4
100	R:R:D121	R:R:I124	4.2	No	No	0	4	4
101	R:R:D121	R:R:F179	9.55	No	Yes	0	4	3
102	R:R:F179	R:R:S122	5.28	Yes	No	8	3	4
103	R:R:I180	R:R:S122	3.1	No	No	8	5	4
104	R:R:C125	R:R:F179	8.38	No	Yes	0	4	3
105	R:R:G173	R:R:I126	5.29	No	No	0	4	4
106	R:R:G176	R:R:I126	3.53	No	No	0	6	4
107	R:R:L128	R:R:W255	6.83	No	Yes	0	5	8
108	R:R:C172	R:R:V129	6.83	No	No	0	8	5
109	R:R:M195	R:R:V129	3.04	No	No	0	4	5
110	R:R:A130	R:R:W169	5.19	No	Yes	0	7	9
111	R:R:A130	R:R:C172	3.61	No	No	0	7	8
112	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
113	R:R:F196	R:R:I132	3.77	Yes	No	1	7	7
114	R:R:I132	R:R:M199	2.92	No	Yes	0	7	7
115	R:R:I132	R:R:W255	8.22	No	Yes	1	7	8
116	R:R:C133	R:R:I168	3.27	No	No	0	5	6
117	R:R:C133	R:R:C172	3.64	No	No	0	5	8
118	R:R:C133	R:R:M199	3.24	No	Yes	0	5	7
119	R:R:N134	R:R:W169	3.39	No	Yes	2	8	9
120	R:R:L135	R:R:M203	2.83	Yes	Yes	2	8	8
121	R:R:F251	R:R:L135	3.65	No	Yes	2	8	8
122	R:R:L135	R:R:Y299	10.55	Yes	Yes	2	8	9
123	R:R:L136	R:R:M199	7.07	No	Yes	0	7	7
124	R:R:L136	R:R:L202	6.92	No	No	0	7	5
125	R:R:L136	R:R:M203	4.24	No	Yes	0	7	8
126	R:R:I138	R:R:R142	7.52	Yes	No	0	8	9
127	R:R:I138	R:R:Y299	9.67	Yes	Yes	2	8	9
128	R:R:A139	R:R:M203	3.22	No	Yes	2	8	8
129	R:R:A139	R:R:Y207	2.67	No	Yes	2	8	9
130	R:R:L206	R:R:V140	2.98	No	No	0	6	6
131	R:R:D141	R:R:Y152	5.75	No	Yes	0	9	8
132	R:R:R142	R:R:Y207	7.2	No	Yes	0	9	9
133	R:R:M210	R:R:R142	2.48	No	No	0	9	9
134	R:R:F147	R:R:Y143	27.85	Yes	Yes	4	6	8
135	R:R:L206	R:R:Y143	11.72	No	Yes	0	6	8
136	R:R:H209	R:R:Y143	9.8	No	Yes	4	6	8
137	R:R:M210	R:R:Y143	3.59	No	Yes	4	9	8
138	R:R:V144	R:R:Y148	2.52	No	No	0	6	5
139	R:R:V144	R:R:Y152	5.05	No	Yes	0	6	8
140	R:R:T145	R:R:Y152	8.74	No	Yes	0	8	8
141	R:R:F147	R:R:I146	8.79	Yes	No	4	6	9
142	R:R:F213	R:R:I146	2.51	Yes	No	4	5	9
143	R:R:F147	R:R:H209	9.05	Yes	No	4	6	6
144	R:R:F147	R:R:M210	2.49	Yes	No	4	6	9
145	R:R:F147	R:R:F213	6.43	Yes	Yes	4	6	5
146	R:R:R151	R:R:S154	7.91	No	No	0	6	5
147	R:R:I155	R:R:R151	2.51	No	No	0	5	6
148	R:R:M156	R:R:Y152	16.76	No	Yes	0	8	8
149	R:R:K160	R:R:T157	4.5	No	No	0	7	8
150	R:R:I165	R:R:W169	2.35	No	Yes	2	7	9
151	R:R:F179	R:R:I180	3.77	Yes	No	8	3	5
152	R:R:E184	R:R:F179	15.16	No	Yes	0	4	3
153	R:R:S185	R:R:Y182	7.63	No	No	0	4	5
154	R:R:M187	R:R:Y182	2.39	No	No	0	5	5
155	R:R:E184	R:R:S183	4.31	No	No	0	4	5
156	R:R:E184	R:R:V188	2.85	No	No	0	4	5
157	R:R:K186	R:R:M187	2.88	No	No	0	4	5
158	R:R:I189	R:R:I193	2.94	No	No	1	6	4
159	R:R:I189	R:R:L262	7.14	No	No	1	6	5
160	R:R:I189	R:R:I266	17.66	No	Yes	1	6	3
161	R:R:F259	R:R:L192	7.31	Yes	No	0	6	4
162	R:R:I193	R:R:L262	2.85	No	No	1	4	5
163	R:R:I193	R:R:V263	7.68	No	No	0	4	5
164	R:R:M195	R:R:M199	4.33	No	Yes	0	4	7
165	R:R:F196	R:R:F197	5.36	Yes	No	0	7	4
166	R:R:F196	R:R:W255	11.02	Yes	Yes	1	7	8
167	R:R:F196	R:R:F259	33.22	Yes	Yes	1	7	6
168	R:R:F251	R:R:M200	2.49	No	No	0	8	6
169	R:R:I252	R:R:M200	7.29	No	No	0	5	6
170	R:R:L202	R:R:L206	4.15	No	No	0	5	6
171	R:R:M203	R:R:Y207	2.39	Yes	Yes	2	8	9
172	R:R:F251	R:R:M203	9.95	No	Yes	2	8	8
173	R:R:G204	R:R:L248	5.13	No	No	0	5	7
174	R:R:I244	R:R:Y207	2.42	Yes	Yes	0	7	9
175	R:R:L247	R:R:Y207	4.69	Yes	Yes	2	8	9
176	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
177	R:R:F211	R:R:L212	2.44	Yes	No	5	6	3
178	R:R:F211	R:R:R215	7.48	Yes	No	5	6	6
179	R:R:C237	R:R:F211	2.79	No	Yes	5	6	6
180	R:R:F211	R:R:G240	3.01	Yes	No	0	6	8
181	R:R:A241	R:R:F211	2.77	No	Yes	0	7	6
182	R:R:L212	R:R:R215	2.43	No	No	5	3	6
183	R:R:F213	R:R:H217	9.05	Yes	No	0	5	7
184	R:R:C237	R:R:R215	11.14	No	No	5	6	6
185	R:R:H217	R:R:R220	3.39	No	No	0	7	6
186	R:R:I246	R:R:V242	3.07	No	No	0	7	7
187	R:R:L247	R:R:T243	2.95	Yes	No	0	8	9
188	R:R:I244	R:R:L248	2.85	Yes	No	0	7	7
189	R:R:I246	R:R:I298	2.94	No	Yes	0	7	9
190	R:R:I298	R:R:L247	5.71	Yes	Yes	2	9	8
191	R:R:L247	R:R:Y299	2.34	Yes	Yes	2	8	9
192	R:R:I294	R:R:V250	4.61	No	No	2	6	6
193	R:R:I298	R:R:V250	4.61	Yes	No	2	9	6
194	R:R:C254	R:R:N291	4.72	No	No	0	8	9
195	R:R:F259	R:R:W255	3.01	Yes	Yes	1	6	8
196	R:R:I288	R:R:W255	4.7	No	Yes	0	6	8
197	R:R:N291	R:R:W255	13.56	No	Yes	0	9	8
198	R:R:P257	R:R:Y284	2.78	No	Yes	0	9	5
199	R:R:L287	R:R:P257	3.28	No	No	0	7	9
200	R:R:F258	R:R:F281	3.22	No	No	1	5	3
201	R:R:F258	R:R:L285	2.44	No	Yes	1	5	3
202	R:R:L260	R:R:L264	6.92	No	No	1	5	5
203	R:R:L260	R:R:Y277	10.55	No	No	1	5	1
204	R:R:H261	R:R:I265	14.58	Yes	No	1	5	3
205	R:R:H261	R:R:T278	8.21	Yes	No	1	5	3
206	R:R:F281	R:R:H261	9.05	No	Yes	1	3	5
207	R:R:H261	R:R:Y284	6.53	Yes	Yes	1	5	5
208	R:R:I266	R:R:L262	2.85	Yes	No	1	3	5
209	R:R:C268	R:R:L264	4.76	No	No	0	4	5
210	R:R:L264	R:R:Y277	8.21	No	No	1	5	1
211	R:R:I265	R:R:I266	4.42	No	Yes	1	3	3
212	R:R:I265	R:R:T278	4.56	No	No	1	3	3
213	R:R:C268	R:R:C274	7.28	No	No	0	4	4
214	R:R:N271	R:R:P272	6.52	No	No	0	4	1
215	R:R:N271	R:R:Y273	9.3	No	No	0	4	3
216	R:R:C274	R:R:N271	6.3	No	No	0	4	4
217	R:R:I275	R:R:T278	3.04	No	No	0	1	3
218	R:R:Y277	R:R:Y284	11.91	No	Yes	1	1	5
219	R:R:A279	R:R:H280	2.93	No	No	0	3	3
220	R:R:H280	R:R:T283	6.85	No	No	1	3	4
221	R:R:H280	R:R:Y284	3.27	No	Yes	1	3	5
222	R:R:F281	R:R:L285	9.74	No	Yes	1	3	3
223	R:R:T283	R:R:Y284	3.75	No	Yes	1	4	5
224	R:R:L285	R:R:M289	2.83	Yes	Yes	1	3	6
225	R:R:D295	R:R:N291	14.81	No	No	0	9	9
226	R:R:I294	R:R:I298	4.42	No	Yes	2	6	9
227	R:R:D295	R:R:P296	3.22	No	No	0	9	9
228	R:R:F301	R:R:L297	2.44	Yes	No	0	6	5
229	R:R:I298	R:R:Y299	2.42	Yes	Yes	2	9	9
230	R:R:A300	R:R:L306	3.15	No	Yes	0	8	8
231	R:R:F301	R:R:L306	2.44	Yes	Yes	0	6	8
232	R:R:F301	R:R:F310	4.29	Yes	No	0	6	7
233	R:R:R302	R:R:R307	4.26	No	No	0	8	8
234	R:R:E305	R:R:S303	5.75	No	No	3	6	8
235	R:R:L306	R:R:S303	3	Yes	No	3	8	8
236	R:R:L304	R:R:R307	2.43	No	No	0	5	8
237	R:R:L304	R:R:N308	2.75	No	No	0	5	4
238	R:R:F310	R:R:R307	3.21	No	No	0	7	8
239	R:R:F112	R:R:H115	2.26	No	No	0	1	4
240	R:R:F258	R:R:F259	2.14	No	Yes	1	5	6
241	R:R:C125	R:R:G176	1.96	No	No	0	4	6
242	R:R:P225	R:R:P226	1.95	No	No	0	3	3
243	R:R:C268	R:R:P269	1.88	No	No	0	4	2
244	R:R:A256	R:R:P257	1.87	No	No	0	5	9
245	R:R:G49	R:R:S52	1.86	No	No	6	6	7
246	R:R:G49	R:R:S88	1.86	No	No	6	6	8
247	R:R:G249	R:R:I252	1.76	No	No	0	6	5
248	R:R:P269	R:R:T270	1.75	No	No	0	2	1
249	R:R:G49	R:R:L48	1.71	No	Yes	0	6	6
250	R:R:C175	R:R:V174	1.71	No	No	0	4	3
251	R:R:C290	R:R:V286	1.71	No	No	0	5	5
252	R:R:L224	R:R:P225	1.64	No	No	0	5	3
253	R:R:V63	R:R:V64	1.6	Yes	No	0	8	4
254	R:R:V166	R:R:V170	1.6	No	No	0	5	4
255	R:R:V170	R:R:V174	1.6	No	No	0	4	3
256	R:R:V177	R:R:V181	1.6	No	No	0	4	2
257	R:R:C290	R:R:L48	1.59	No	Yes	0	5	6
258	R:R:T194	R:R:V190	1.59	No	No	0	4	4
259	R:R:T267	R:R:V263	1.59	No	No	0	4	5
260	R:R:I180	R:R:V181	1.54	No	No	0	5	2
261	R:R:M97	R:R:V101	1.52	No	No	0	4	3
262	R:R:M238	R:R:V242	1.52	No	No	0	4	7
263	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
264	R:R:L61	R:R:V64	1.49	No	No	0	5	4
265	R:R:L212	R:R:V208	1.49	No	No	0	3	3
266	R:R:I100	R:R:I96	1.47	No	No	0	3	5
267	R:R:I155	R:R:K160	1.45	No	No	0	5	7
268	R:R:I266	R:R:K186	1.45	Yes	No	0	3	4
269	R:R:I96	R:R:L46	1.43	No	No	0	5	5
270	R:R:L201	R:R:M200	1.41	No	No	0	4	6
271	R:R:D110	R:R:I113	1.4	No	No	0	6	8
272	R:R:D117	R:R:M97	1.39	No	No	0	3	4
273	R:R:F75	R:R:V63	1.31	Yes	Yes	0	4	8
274	R:R:R159	R:R:T157	1.29	No	No	0	4	8
275	R:R:H115	R:R:N118	1.28	No	No	0	4	4
276	R:R:V178	R:R:Y182	1.26	No	No	0	4	5
277	R:R:F253	R:R:I252	1.26	No	No	0	5	5
278	R:R:F213	R:R:L216	1.22	Yes	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F45	5.425	4	0	7
2	R:R:L48	3.3625	4	0	6
3	R:R:N56	7.165	4	0	9
4	R:R:V63	2.6375	4	0	8
5	R:R:L69	7.614	5	3	8
6	R:R:P72	4.225	4	2	6
7	R:R:Y74	6.96	8	3	8
8	R:R:F75	3.6375	4	0	4
9	R:R:F76	3.28833	6	2	7
10	R:R:L80	5.148	5	2	9
11	R:R:D84	7.516	5	0	9
12	R:R:F120	4.654	5	0	5
13	R:R:L135	5.6425	4	2	8
14	R:R:I138	5.7225	4	2	8
15	R:R:Y143	13.24	4	4	8
16	R:R:F147	10.922	5	4	6
17	R:R:Y152	9.075	4	0	8
18	R:R:W169	3.84	7	2	9
19	R:R:F179	8.428	5	8	3
20	R:R:F196	13.3425	4	1	7
21	R:R:M199	4.39	4	0	7
22	R:R:M203	4.526	5	2	8
23	R:R:Y207	3.874	5	2	9
24	R:R:F211	3.698	5	5	6
25	R:R:F213	4.8025	4	4	5
26	R:R:I244	2.465	4	0	7
27	R:R:L247	3.9225	4	2	8
28	R:R:W255	7.46857	7	1	8
29	R:R:F259	11.42	4	1	6
30	R:R:H261	9.5925	4	1	5
31	R:R:I266	6.595	4	1	3
32	R:R:Y284	5.648	5	1	5
33	R:R:L285	5.8125	4	1	3
34	R:R:M289	4.7675	4	1	6
35	R:R:I298	4.02	5	2	9
36	R:R:Y299	5.464	5	2	9
37	R:R:F301	3.32	5	0	6
38	R:R:L306	3.625	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F45	R:R:T95	22.9439	9.08	Yes	No	0	7	5
2	R:R:F45	R:R:M289	32.1573	4.98	Yes	Yes	0	7	6
3	R:R:E55	R:R:P296	16.3872	6.29	No	No	0	7	9
4	R:R:D295	R:R:P296	13.9378	3.22	No	No	0	9	9
5	R:R:D295	R:R:N291	12.9392	14.81	No	No	0	9	9
6	R:R:N291	R:R:W255	12.553	13.56	No	Yes	0	9	8
7	R:R:F259	R:R:W255	79.3453	3.01	Yes	Yes	1	6	8
8	R:R:F258	R:R:F259	100	2.14	No	Yes	1	5	6
9	R:R:F258	R:R:L285	65.073	2.44	No	Yes	1	5	3
10	R:R:L285	R:R:M289	39.4677	2.83	Yes	Yes	1	3	6
11	R:R:D84	R:R:S131	48.926	4.42	Yes	No	0	9	9
12	R:R:S131	R:R:W255	48.6905	4.94	No	Yes	0	9	8
13	R:R:E55	R:R:F301	13.773	3.5	No	Yes	0	7	6
14	R:R:I138	R:R:L77	38.3891	2.85	Yes	No	0	8	8
15	R:R:I138	R:R:L80	31.5827	2.85	Yes	Yes	2	8	9
16	R:R:D84	R:R:L80	55.935	8.14	Yes	Yes	0	9	9
17	R:R:V63	R:R:Y74	14.1922	2.52	Yes	Yes	0	8	8
18	R:R:L77	R:R:Y74	29.6185	2.34	No	Yes	0	8	8
19	R:R:F301	R:R:L306	13.17	2.44	Yes	Yes	0	6	8
20	R:R:L80	R:R:N134	28.5634	6.87	Yes	No	2	9	8
21	R:R:F76	R:R:I165	17.6825	3.77	Yes	No	2	7	7
22	R:R:N134	R:R:W169	17.772	3.39	No	Yes	2	8	9
23	R:R:I165	R:R:W169	10.9374	2.35	No	Yes	2	7	9
24	R:R:L135	R:R:L80	12.8686	5.54	Yes	Yes	2	8	9
25	R:R:F120	R:R:M123	18.3184	2.49	Yes	No	0	5	4
26	R:R:E94	R:R:F120	18.4362	3.5	No	Yes	0	5	5
27	R:R:E94	R:R:T95	20.6171	8.47	No	No	0	5	5
28	R:R:I124	R:R:N91	36.5191	7.08	No	No	0	4	6
29	R:R:I124	R:R:S90	20.6265	7.74	No	No	0	4	5
30	R:R:F120	R:R:M97	14.6491	3.73	Yes	No	0	5	4
31	R:R:I119	R:R:N118	12.4541	9.91	No	No	0	5	4
32	R:R:I119	R:R:M116	14.9176	2.92	No	No	0	5	5
33	R:R:F120	R:R:M116	17.3716	7.46	Yes	No	0	5	5
34	R:R:D121	R:R:I124	17.1408	4.2	No	No	0	4	4
35	R:R:D121	R:R:F179	15.8785	9.55	No	Yes	0	4	3
36	R:R:I132	R:R:M199	42.6849	2.92	No	Yes	0	7	7
37	R:R:F196	R:R:I132	21.1493	3.77	Yes	No	1	7	7
38	R:R:F196	R:R:F259	21.5544	33.22	Yes	Yes	1	7	6
39	R:R:I132	R:R:W255	22.5012	8.22	No	Yes	1	7	8
40	R:R:L136	R:R:M203	28.0122	4.24	No	Yes	0	7	8
41	R:R:L136	R:R:M199	37.9275	7.07	No	Yes	0	7	7
42	R:R:L136	R:R:L202	14.0697	6.92	No	No	0	7	5
43	R:R:I138	R:R:R142	19.8493	7.52	Yes	No	0	8	9
44	R:R:M203	R:R:Y207	19.3311	2.39	Yes	Yes	2	8	9
45	R:R:L202	R:R:L206	11.8935	4.15	No	No	0	5	6
46	R:R:M210	R:R:R142	12.162	2.48	No	No	0	9	9
47	R:R:L206	R:R:Y143	10.2449	11.72	No	Yes	0	6	8
48	R:R:F281	R:R:L285	11.3754	9.74	No	Yes	1	3	3
49	R:R:F281	R:R:H261	44.7292	9.05	No	Yes	1	3	5
50	R:R:H261	R:R:I265	20.3862	14.58	Yes	No	1	5	3
51	R:R:I265	R:R:I266	19.1992	4.42	No	Yes	1	3	3
52	R:R:F251	R:R:M200	13.2077	2.49	No	No	0	8	6
53	R:R:I244	R:R:Y207	25.3038	2.42	Yes	Yes	0	7	9
54	R:R:I244	R:R:V208	16.976	3.07	Yes	No	0	7	3
55	R:R:L212	R:R:V208	14.8705	1.49	No	No	0	3	3
56	R:R:H261	R:R:Y284	23.1795	6.53	Yes	Yes	1	5	5
57	R:R:Y277	R:R:Y284	13.9237	11.91	No	Yes	1	1	5
58	R:R:L264	R:R:Y277	11.2529	8.21	No	No	1	5	1
59	R:R:F301	R:R:F310	10.6171	4.29	Yes	No	0	6	7
60	R:R:M123	R:R:S90	19.4395	10.73	No	No	0	4	5
61	R:R:L285	R:R:N91	36.1564	8.24	Yes	No	1	3	6
62	R:R:R142	R:R:Y207	10.1366	7.2	No	Yes	0	9	9
63	R:R:F258	R:R:F281	34.4512	3.22	No	No	1	5	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K3F_nogp

PDB Summary
PDB	9K3F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.28
Number of Linked Nodes	240
Number of Links	278
Number of Hubs	38
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	68
Number of Links involved in Communities	93

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	40238
Length Of Smallest Path	3
Average Path Length	12.6366
Length of Longest Path	26
Minimum Path Strength	1.45
Average Path Strength	5.37193
Maximum Path Strength	20.265
Minimum Path Correlation	0.7
Average Path Correlation	0.939086
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.7619
Average % Of Corr. Nodes	58.167
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9705
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>9K3F_nogp_Chain_R C E Q V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L P P S C M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K3F_nogp.zip

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