psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	L:L:G4	3.14	No	No	0	0	0
2	I:I:?1	R:R:D117	7.49	No	Yes	0	0	3
3	I:I:?1	R:R:D121	7.49	No	Yes	0	0	4
4	L:L:Y1	R:R:D110	4.6	No	No	0	0	6
5	L:L:Y1	R:R:D117	8.05	No	Yes	0	0	3
6	L:L:M3	R:R:M97	5.78	No	No	0	0	4
7	L:L:M3	R:R:I98	8.75	No	No	0	0	4
8	L:L:M3	R:R:I113	2.92	No	No	0	0	8
9	L:L:H5	R:R:F45	16.97	No	Yes	5	0	7
10	L:L:H5	R:R:T95	9.58	No	Yes	5	0	5
11	L:L:F6	R:R:D121	5.97	Yes	Yes	0	0	4
12	L:L:F6	R:R:I124	8.79	Yes	Yes	0	0	4
13	L:L:F6	R:R:F258	5.36	Yes	No	6	0	5
14	L:L:F6	R:R:F281	3.22	Yes	Yes	6	0	3
15	L:L:F6	R:R:L285	3.65	Yes	No	0	0	3
16	L:L:R7	L:L:W8	6	Yes	Yes	2	0	0
17	L:L:R7	R:R:D117	3.57	Yes	Yes	2	0	3
18	L:L:R7	R:R:N118	4.82	Yes	No	2	0	4
19	L:L:R7	R:R:D121	11.91	Yes	Yes	0	0	4
20	L:L:R7	R:R:I180	8.77	Yes	No	0	0	5
21	L:L:R7	R:R:E184	19.77	Yes	No	2	0	4
22	L:L:W8	R:R:E184	3.27	Yes	No	2	0	4
23	L:L:W8	R:R:I189	9.4	Yes	No	0	0	6
24	L:L:W8	R:R:L192	3.42	Yes	No	0	0	4
25	L:L:D9	L:L:R10	3.57	No	No	0	0	0
26	L:L:D9	R:R:F281	16.72	No	Yes	0	0	3
27	R:R:I40	R:R:V44	3.07	No	No	0	5	4
28	R:R:F45	R:R:I40	5.02	Yes	No	0	7	5
29	R:R:E43	R:R:K41	9.45	No	No	0	3	4
30	R:R:E43	R:R:P42	3.14	No	No	0	3	4
31	R:R:F45	R:R:T95	10.38	Yes	Yes	5	7	5
32	R:R:F45	R:R:M289	3.73	Yes	No	0	7	6
33	R:R:I96	R:R:L46	4.28	No	No	0	5	5
34	R:R:L48	R:R:M289	7.07	No	No	0	6	6
35	R:R:C290	R:R:L48	3.17	No	No	0	5	6
36	R:R:G49	R:R:S88	3.71	No	No	0	6	8
37	R:R:S52	R:R:S88	6.52	No	No	0	7	8
38	R:R:S52	R:R:V293	3.23	No	No	0	7	5
39	R:R:E55	R:R:P296	4.72	No	No	0	7	9
40	R:R:E55	R:R:L297	6.63	No	No	7	7	5
41	R:R:E55	R:R:F301	8.16	No	Yes	7	7	6
42	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
43	R:R:D84	R:R:N56	4.04	Yes	Yes	0	9	9
44	R:R:N56	R:R:P296	4.89	Yes	No	0	9	9
45	R:R:I57	R:R:I60	2.94	No	No	0	4	8
46	R:R:A300	R:R:V59	3.39	No	No	0	8	9
47	R:R:F301	R:R:V59	3.93	Yes	No	0	6	9
48	R:R:A81	R:R:I60	3.25	No	No	0	9	8
49	R:R:A62	R:R:L306	3.15	No	Yes	0	8	8
50	R:R:C78	R:R:V63	5.12	No	No	0	7	8
51	R:R:L306	R:R:V63	2.98	Yes	No	0	8	8
52	R:R:N66	R:R:R65	3.62	Yes	No	1	7	5
53	R:R:R65	R:R:T309	3.88	No	No	1	5	8
54	R:R:G67	R:R:N66	5.09	No	Yes	0	5	7
55	R:R:N66	R:R:N68	8.17	Yes	Yes	1	7	7
56	R:R:N66	R:R:T309	5.85	Yes	No	1	7	8
57	R:R:N68	R:R:Y74	8.14	Yes	Yes	1	7	8
58	R:R:E305	R:R:N68	13.15	No	Yes	1	6	7
59	R:R:L306	R:R:N68	4.12	Yes	Yes	0	8	7
60	R:R:H70	R:R:L69	7.71	No	No	0	8	8
61	R:R:P72	R:R:S71	3.56	No	No	0	6	7
62	R:R:M156	R:R:P72	3.35	No	No	0	8	6
63	R:R:A161	R:R:P72	3.74	No	No	0	6	6
64	R:R:M73	R:R:Y74	14.37	No	Yes	0	8	8
65	R:R:S303	R:R:Y74	3.82	No	Yes	0	8	8
66	R:R:E305	R:R:Y74	4.49	No	Yes	1	6	8
67	R:R:F75	R:R:V158	3.93	No	No	0	4	1
68	R:R:F75	R:R:L162	4.87	No	No	0	4	2
69	R:R:D141	R:R:F76	7.17	No	Yes	0	9	7
70	R:R:F76	R:R:L164	3.65	Yes	No	0	7	6
71	R:R:F76	R:R:I165	6.28	Yes	No	0	7	7
72	R:R:N134	R:R:S79	5.96	No	No	9	8	9
73	R:R:I165	R:R:S79	6.19	No	No	0	7	9
74	R:R:S79	R:R:W169	3.71	No	Yes	9	9	9
75	R:R:D84	R:R:L80	6.79	Yes	No	0	9	9
76	R:R:L135	R:R:L80	4.15	No	No	0	8	9
77	R:R:V82	R:R:W169	3.68	No	Yes	0	7	9
78	R:R:D84	R:R:S131	5.89	Yes	No	0	9	9
79	R:R:D84	R:R:S292	8.83	Yes	No	0	9	9
80	R:R:D295	R:R:D84	6.65	No	Yes	0	9	9
81	R:R:L86	R:R:V89	2.98	No	No	0	6	5
82	R:R:N91	R:R:V87	2.96	No	No	0	6	8
83	R:R:S127	R:R:V87	6.46	No	No	0	7	8
84	R:R:S292	R:R:S88	3.26	No	No	0	9	8
85	R:R:M123	R:R:S90	6.13	No	No	0	4	5
86	R:R:I124	R:R:N91	7.08	Yes	No	0	4	6
87	R:R:M289	R:R:N91	8.41	No	No	0	6	6
88	R:R:E94	R:R:F120	5.83	No	Yes	0	5	5
89	R:R:D121	R:R:E94	9.09	Yes	No	0	4	5
90	R:R:E94	R:R:I124	4.1	No	Yes	0	5	4
91	R:R:F120	R:R:M97	3.73	Yes	No	0	5	4
92	R:R:I100	R:R:V101	3.07	No	No	0	3	3
93	R:R:H102	R:R:S103	4.18	No	No	0	5	4
94	R:R:F112	R:R:T107	5.19	No	No	0	1	4
95	R:R:F108	R:R:Q111	8.2	No	No	0	3	2
96	R:R:F108	R:R:F112	3.22	No	No	0	3	1
97	R:R:D110	R:R:E109	15.59	No	No	0	6	3
98	R:R:H115	R:R:Q111	6.18	No	No	0	4	2
99	R:R:F112	R:R:M116	11.2	No	No	0	1	5
100	R:R:N118	R:R:Q114	3.96	No	No	0	4	5
101	R:R:I119	R:R:M116	2.92	No	No	0	5	5
102	R:R:F120	R:R:M116	3.73	Yes	No	0	5	5
103	R:R:D117	R:R:N118	5.39	Yes	No	2	3	4
104	R:R:I180	R:R:S122	7.74	No	No	0	5	4
105	R:R:C125	R:R:G176	3.92	Yes	No	0	4	6
106	R:R:C125	R:R:I180	3.27	Yes	No	0	4	5
107	R:R:G173	R:R:I126	7.05	No	No	0	4	4
108	R:R:L128	R:R:W255	3.42	No	Yes	0	5	8
109	R:R:C172	R:R:V129	6.83	No	No	0	8	5
110	R:R:A130	R:R:W169	7.78	No	Yes	0	7	9
111	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
112	R:R:I132	R:R:M199	5.83	No	No	0	7	7
113	R:R:I132	R:R:W255	7.05	No	Yes	0	7	8
114	R:R:C133	R:R:I168	3.27	No	No	0	5	6
115	R:R:C133	R:R:C172	3.64	No	No	0	5	8
116	R:R:N134	R:R:W169	4.52	No	Yes	9	8	9
117	R:R:L135	R:R:Y299	4.69	No	Yes	0	8	9
118	R:R:L136	R:R:L202	4.15	No	No	0	7	5
119	R:R:I138	R:R:R142	3.76	No	Yes	3	8	9
120	R:R:I138	R:R:Y299	4.84	No	Yes	3	8	9
121	R:R:A139	R:R:Y207	5.34	No	Yes	0	8	9
122	R:R:L206	R:R:V140	2.98	No	No	0	6	6
123	R:R:D141	R:R:T145	4.34	No	No	8	9	8
124	R:R:D141	R:R:Y152	5.75	No	Yes	8	9	8
125	R:R:R142	R:R:Y207	7.2	Yes	Yes	3	9	9
126	R:R:R142	R:R:Y299	6.17	Yes	Yes	3	9	9
127	R:R:F147	R:R:Y143	16.5	Yes	No	10	6	8
128	R:R:L206	R:R:Y143	5.86	No	No	0	6	8
129	R:R:H209	R:R:Y143	9.8	No	No	10	6	8
130	R:R:I155	R:R:V144	3.07	No	No	0	5	6
131	R:R:T145	R:R:Y152	7.49	No	Yes	8	8	8
132	R:R:F147	R:R:I146	5.02	Yes	No	0	6	9
133	R:R:I146	R:R:M210	2.92	No	No	0	9	9
134	R:R:F147	R:R:H209	11.31	Yes	No	10	6	6
135	R:R:F147	R:R:F213	9.65	Yes	No	0	6	5
136	R:R:H153	R:R:Y152	9.8	No	Yes	0	5	8
137	R:R:M156	R:R:Y152	8.38	No	Yes	0	8	8
138	R:R:F179	R:R:V188	3.93	Yes	No	0	3	5
139	R:R:S183	R:R:Y182	5.09	No	No	0	5	5
140	R:R:K186	R:R:S183	4.59	No	No	0	4	5
141	R:R:M187	R:R:V190	4.56	No	No	0	5	4
142	R:R:I189	R:R:I266	2.94	No	No	0	6	3
143	R:R:F196	R:R:F197	5.36	Yes	No	0	7	4
144	R:R:F196	R:R:M200	6.22	Yes	No	4	7	6
145	R:R:F196	R:R:F251	3.22	Yes	Yes	4	7	8
146	R:R:F196	R:R:W255	4.01	Yes	Yes	4	7	8
147	R:R:F196	R:R:F259	30.01	Yes	No	0	7	6
148	R:R:F251	R:R:M200	3.73	Yes	No	4	8	6
149	R:R:I252	R:R:M200	4.37	No	No	0	5	6
150	R:R:M203	R:R:Y207	3.59	No	Yes	0	8	9
151	R:R:F251	R:R:M203	8.71	Yes	No	0	8	8
152	R:R:G204	R:R:L248	3.42	No	No	0	5	7
153	R:R:I244	R:R:Y207	3.63	No	Yes	0	7	9
154	R:R:L247	R:R:Y207	4.69	No	Yes	3	8	9
155	R:R:L248	R:R:Y207	4.69	No	Yes	0	7	9
156	R:R:Y207	R:R:Y299	4.96	Yes	Yes	3	9	9
157	R:R:F211	R:R:R215	9.62	Yes	No	0	6	6
158	R:R:F211	R:R:G240	3.01	Yes	No	0	6	8
159	R:R:F211	R:R:I244	5.02	Yes	No	0	6	7
160	R:R:F213	R:R:H217	9.05	No	No	0	5	7
161	R:R:K219	R:R:R215	4.95	No	No	0	5	6
162	R:R:H217	R:R:R220	15.8	No	No	0	7	6
163	R:R:G240	R:R:T243	3.64	No	No	0	8	9
164	R:R:L247	R:R:Y299	4.69	No	Yes	3	8	9
165	R:R:F253	R:R:G249	3.01	No	No	0	5	6
166	R:R:F251	R:R:W255	8.02	Yes	Yes	4	8	8
167	R:R:C254	R:R:N291	6.3	No	No	0	8	9
168	R:R:I288	R:R:W255	4.7	No	Yes	0	6	8
169	R:R:N291	R:R:W255	12.43	No	Yes	0	9	8
170	R:R:P257	R:R:Y284	4.17	No	Yes	0	9	5
171	R:R:L287	R:R:P257	4.93	No	No	0	7	9
172	R:R:F258	R:R:F259	4.29	No	No	0	5	6
173	R:R:F258	R:R:F281	5.36	No	Yes	6	5	3
174	R:R:L260	R:R:Y277	9.38	No	No	0	5	1
175	R:R:H261	R:R:I265	6.63	Yes	No	0	5	3
176	R:R:H261	R:R:T278	4.11	Yes	No	0	5	3
177	R:R:F281	R:R:H261	12.44	Yes	Yes	0	3	5
178	R:R:H261	R:R:Y284	3.27	Yes	Yes	0	5	5
179	R:R:I275	R:R:L264	5.71	No	No	11	1	5
180	R:R:L264	R:R:Y277	3.52	No	No	0	5	1
181	R:R:L264	R:R:T278	4.42	No	No	11	5	3
182	R:R:C268	R:R:T267	3.38	Yes	No	0	4	4
183	R:R:C268	R:R:N271	3.15	Yes	No	0	4	4
184	R:R:C268	R:R:I275	4.91	Yes	No	0	4	1
185	R:R:N271	R:R:P272	6.52	No	No	0	4	1
186	R:R:N271	R:R:Y273	4.65	No	No	0	4	3
187	R:R:I275	R:R:T278	3.04	No	No	11	1	3
188	R:R:Y277	R:R:Y284	18.86	No	Yes	0	1	5
189	R:R:H280	R:R:T283	4.11	No	No	0	3	4
190	R:R:H280	R:R:Y284	3.27	No	Yes	0	3	5
191	R:R:F281	R:R:N282	3.62	Yes	No	0	3	3
192	R:R:T283	R:R:V286	4.76	No	No	0	4	5
193	R:R:D295	R:R:N291	13.46	No	No	0	9	9
194	R:R:I294	R:R:I298	5.89	No	No	0	6	9
195	R:R:D295	R:R:Y299	3.45	No	Yes	0	9	9
196	R:R:F301	R:R:L297	3.65	Yes	No	7	6	5
197	R:R:I298	R:R:Y299	4.84	No	Yes	0	9	9
198	R:R:F301	R:R:F310	9.65	Yes	No	0	6	7
199	R:R:R302	R:R:R307	5.33	No	No	0	8	8
200	R:R:L306	R:R:S303	6.01	Yes	No	0	8	8
201	R:R:M195	R:R:M199	2.89	No	No	0	4	7
202	R:R:I193	R:R:L262	2.85	No	No	0	4	5
203	R:R:I265	R:R:L262	2.85	No	No	0	3	5
204	R:R:M85	R:R:N56	2.8	No	Yes	0	6	9
205	R:R:C125	R:R:F179	2.79	Yes	Yes	0	4	3
206	R:R:C175	R:R:F179	2.79	No	Yes	0	4	3
207	R:R:A62	R:R:F310	2.77	No	No	0	8	7
208	R:R:A137	R:R:F76	2.77	No	Yes	0	7	7
209	R:R:A241	R:R:F211	2.77	No	Yes	0	7	6
210	R:R:L80	R:R:N134	2.75	No	No	0	9	8
211	R:R:R151	R:R:S154	2.64	No	No	0	6	5
212	R:R:A83	R:R:W169	2.59	No	Yes	0	8	9
213	R:R:V144	R:R:Y152	2.52	No	Yes	0	6	8
214	L:L:F11	R:R:I265	2.51	No	No	0	0	3
215	R:R:M210	R:R:R142	2.48	No	Yes	0	9	9
216	R:R:M238	R:R:R215	2.48	No	No	0	4	6
217	R:R:F120	R:R:L93	2.44	Yes	No	0	5	6
218	R:R:F211	R:R:L212	2.44	Yes	No	0	6	3
219	R:R:L77	R:R:Y74	2.34	No	Yes	0	8	8
220	R:R:L77	R:R:Y299	2.34	No	Yes	0	8	9
221	R:R:C268	R:R:P269	1.88	Yes	No	0	4	2
222	R:R:A256	R:R:P257	1.87	No	No	0	5	9
223	R:R:G176	R:R:I126	1.76	No	No	0	6	4
224	R:R:P42	R:R:T95	1.75	No	Yes	0	4	5
225	R:R:P269	R:R:T270	1.75	No	No	0	2	1
226	R:R:G240	R:R:K239	1.74	No	No	0	8	8
227	R:R:C125	R:R:V129	1.71	Yes	No	0	4	5
228	R:R:G249	R:R:L248	1.71	No	No	0	6	7
229	R:R:C254	R:R:V250	1.71	No	No	0	8	6
230	R:R:A279	R:R:V38	1.7	No	No	0	3	2
231	R:R:C191	R:R:T194	1.69	No	No	0	5	4
232	R:R:S90	R:R:V89	1.62	No	No	0	5	5
233	R:R:S122	R:R:V177	1.62	No	No	0	4	4
234	R:R:S122	R:R:V181	1.62	No	No	0	4	2
235	R:R:V293	R:R:V51	1.6	No	No	0	5	5
236	R:R:V166	R:R:V170	1.6	No	No	0	5	4
237	R:R:V174	R:R:V178	1.6	No	No	0	3	4
238	R:R:T194	R:R:V190	1.59	No	No	0	4	4
239	R:R:T267	R:R:V263	1.59	No	No	0	4	5
240	R:R:A92	R:R:L46	1.58	No	No	0	6	5
241	R:R:I124	R:R:S90	1.55	Yes	No	0	4	5
242	R:R:I60	R:R:V64	1.54	No	No	0	8	4
243	R:R:I266	R:R:V190	1.54	No	No	0	3	4
244	R:R:I246	R:R:V242	1.54	No	No	0	7	7
245	R:R:K160	R:R:T157	1.5	No	No	0	7	8
246	R:R:L53	R:R:V89	1.49	No	No	0	6	5
247	R:R:L106	R:R:V101	1.49	No	No	0	5	3
248	R:R:L136	R:R:V140	1.49	No	No	0	7	6
249	R:R:L212	R:R:V208	1.49	No	No	0	3	3
250	R:R:L46	R:R:T95	1.47	No	Yes	0	5	5
251	R:R:L206	R:R:T205	1.47	No	No	0	6	4
252	R:R:F39	R:R:P42	1.44	No	No	0	4	4
253	R:R:K160	R:R:M156	1.44	No	No	0	7	8
254	R:R:I50	R:R:L54	1.43	No	No	0	5	4
255	R:R:I57	R:R:L54	1.43	No	No	0	4	4
256	R:R:I113	R:R:L106	1.43	No	No	0	8	5
257	R:R:K219	R:R:L216	1.41	No	No	0	5	5
258	R:R:H70	R:R:V158	1.38	No	No	0	8	1
259	R:R:H102	R:R:I98	1.33	No	No	0	5	4
260	R:R:F179	R:R:V178	1.31	Yes	No	0	3	4
261	R:R:R159	R:R:T157	1.29	No	No	0	4	8
262	R:R:F75	R:R:I165	1.26	No	No	0	4	7
263	R:R:V144	R:R:Y148	1.26	No	No	0	6	5
264	R:R:V178	R:R:Y182	1.26	No	No	0	4	5
265	R:R:I155	R:R:R151	1.25	No	No	0	5	6
266	R:R:I100	R:R:Y105	1.21	No	No	0	3	3
267	R:R:L304	R:R:R307	1.21	No	No	0	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:F6	5.398	5	6	0
2	L:L:R7	9.14	6	2	0
3	L:L:W8	5.5225	4	2	0
4	R:R:F45	9.025	4	5	7
5	R:R:N56	4.105	4	0	9
6	R:R:N66	5.6825	4	1	7
7	R:R:N68	8.395	4	1	7
8	R:R:Y74	6.632	5	1	8
9	R:R:F76	4.9675	4	0	7
10	R:R:D84	6.44	5	0	9
11	R:R:T95	5.795	4	5	5
12	R:R:D117	6.125	4	2	3
13	R:R:F120	3.9325	4	0	5
14	R:R:D121	8.615	4	0	4
15	R:R:I124	5.38	4	0	4
16	R:R:C125	2.9225	4	0	4
17	R:R:R142	4.9025	4	3	9
18	R:R:F147	10.62	4	10	6
19	R:R:Y152	6.788	5	8	8
20	R:R:W169	4.456	5	9	9
21	R:R:F179	2.705	4	0	3
22	R:R:F196	9.764	5	4	7
23	R:R:Y207	4.87143	7	3	9
24	R:R:F211	4.572	5	0	6
25	R:R:F251	5.92	4	4	8
26	R:R:W255	6.36714	7	4	8
27	R:R:H261	6.6125	4	0	5
28	R:R:C268	3.33	4	0	4
29	R:R:F281	8.272	5	6	3
30	R:R:Y284	7.3925	4	0	5
31	R:R:Y299	4.4975	8	3	9
32	R:R:F301	6.3475	4	7	6
33	R:R:L306	4.065	4	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D121	R:R:E94	25.978	9.09	Yes	No	0	4	5
2	R:R:E94	R:R:F120	38.756	5.83	No	Yes	0	5	5
3	R:R:F120	R:R:M97	20.7712	3.73	Yes	No	0	5	4
4	L:L:M3	R:R:M97	18.7072	5.78	No	No	0	0	4
5	L:L:M3	R:R:I113	10.4888	2.92	No	No	0	0	8
6	L:L:F6	R:R:D121	59.363	5.97	Yes	Yes	0	0	4
7	L:L:F6	R:R:I124	42.9449	8.79	Yes	Yes	0	0	4
8	R:R:I124	R:R:N91	25.0962	7.08	Yes	No	0	4	6
9	R:R:M289	R:R:N91	21.1136	8.41	No	No	0	6	6
10	R:R:F45	R:R:M289	17.0466	3.73	Yes	No	0	7	6
11	R:R:E94	R:R:I124	24.2237	4.1	No	Yes	0	5	4
12	R:R:F45	R:R:T95	11.5161	10.38	Yes	Yes	5	7	5
13	L:L:F6	R:R:F258	78.7175	5.36	Yes	No	6	0	5
14	L:L:F6	R:R:F281	14.7387	3.22	Yes	Yes	6	0	3
15	L:L:R7	L:L:W8	10.6061	6	Yes	Yes	2	0	0
16	L:L:R7	R:R:D121	43.0247	11.91	Yes	Yes	0	0	4
17	L:L:R7	R:R:I180	25.7623	8.77	Yes	No	0	0	5
18	R:R:F258	R:R:F259	99.9343	4.29	No	No	0	5	6
19	R:R:F196	R:R:F259	100	30.01	Yes	No	0	7	6
20	R:R:F196	R:R:W255	60.3997	4.01	Yes	Yes	4	7	8
21	R:R:S131	R:R:W255	40.9841	4.94	No	Yes	0	9	8
22	R:R:D84	R:R:S131	40.6792	5.89	Yes	No	0	9	9
23	R:R:D84	R:R:N56	17.7737	4.04	Yes	Yes	0	9	9
24	R:R:F196	R:R:F251	38.9765	3.22	Yes	Yes	4	7	8
25	R:R:F251	R:R:M203	40.2852	8.71	Yes	No	0	8	8
26	R:R:M203	R:R:Y207	39.9897	3.59	No	Yes	0	8	9
27	R:R:Y207	R:R:Y299	22.8915	4.96	Yes	Yes	3	9	9
28	R:R:L77	R:R:Y299	32.4374	2.34	No	Yes	0	8	9
29	R:R:L77	R:R:Y74	30.7487	2.34	No	Yes	0	8	8
30	R:R:N68	R:R:Y74	16.4321	8.14	Yes	Yes	1	7	8
31	R:R:N291	R:R:W255	19.2044	12.43	No	Yes	0	9	8
32	R:R:D295	R:R:N291	18.5852	13.46	No	No	0	9	9
33	R:R:D295	R:R:Y299	22.2816	3.45	No	Yes	0	9	9
34	R:R:D84	R:R:L80	27.8919	6.79	Yes	No	0	9	9
35	R:R:L80	R:R:N134	34.6515	2.75	No	No	0	9	8
36	R:R:N134	R:R:S79	29.1678	5.96	No	No	9	8	9
37	R:R:I165	R:R:S79	28.6284	6.19	No	No	0	7	9
38	R:R:F76	R:R:I165	22.2676	6.28	Yes	No	0	7	7
39	R:R:D141	R:R:F76	18.9511	7.17	No	Yes	0	9	7
40	R:R:D141	R:R:Y152	16.737	5.75	No	Yes	8	9	8
41	R:R:L135	R:R:Y299	10.0103	4.69	No	Yes	0	8	9
42	R:R:F120	R:R:M116	14.6871	3.73	Yes	No	0	5	5
43	R:R:F112	R:R:M116	10.6436	11.2	No	No	0	1	5
44	R:R:C125	R:R:I180	20.9354	3.27	Yes	No	0	4	5
45	R:R:R142	R:R:Y207	11.8069	7.2	Yes	Yes	3	9	9
46	R:R:M210	R:R:R142	15.8551	2.48	No	Yes	0	9	9
47	R:R:I146	R:R:M210	14.6871	2.92	No	No	0	9	9
48	R:R:F147	R:R:I146	13.5097	5.02	Yes	No	0	6	9
49	R:R:C125	R:R:F179	10.7656	2.79	Yes	Yes	0	4	3
50	R:R:I244	R:R:Y207	14.415	3.63	No	Yes	0	7	9
51	R:R:F211	R:R:I244	13.2376	5.02	Yes	No	0	6	7
52	R:R:F281	R:R:H261	31.4242	12.44	Yes	Yes	0	3	5
53	R:R:H261	R:R:Y284	11.8491	3.27	Yes	Yes	0	5	5
54	R:R:H261	R:R:T278	14.4104	4.11	Yes	No	0	5	3
55	R:R:I275	R:R:T278	11.8585	3.04	No	No	11	1	3
56	R:R:C268	R:R:I275	10.9532	4.91	Yes	No	0	4	1
57	R:R:F258	R:R:F281	21.0526	5.36	No	Yes	6	5	3

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
I:I:?1	L:L:G4	3.14	0	No	No	0	0	1	0
I:I:?1	R:R:D117	7.49	0	No	Yes	0	3	1	1
I:I:?1	R:R:D121	7.49	0	No	Yes	0	4	1	1
L:L:Y1	R:R:D110	4.6	0	No	No	0	6	0	1
L:L:Y1	R:R:D117	8.05	0	No	Yes	0	3	0	1
L:L:M3	R:R:M97	5.78	0	No	No	0	4	0	1
L:L:M3	R:R:I98	8.75	0	No	No	0	4	0	1
L:L:M3	R:R:I113	2.92	0	No	No	0	8	0	1
L:L:H5	R:R:F45	16.97	5	No	Yes	0	7	0	1
L:L:H5	R:R:T95	9.58	5	No	Yes	0	5	0	1
L:L:F6	R:R:D121	5.97	6	Yes	Yes	0	4	0	1
L:L:F6	R:R:I124	8.79	6	Yes	Yes	0	4	0	1
L:L:F6	R:R:F258	5.36	6	Yes	No	0	5	0	1
L:L:F6	R:R:F281	3.22	6	Yes	Yes	0	3	0	1
L:L:F6	R:R:L285	3.65	6	Yes	No	0	3	0	1
L:L:R7	R:R:D117	3.57	2	Yes	Yes	0	3	0	1
L:L:R7	R:R:N118	4.82	2	Yes	No	0	4	0	1
L:L:R7	R:R:D121	11.91	2	Yes	Yes	0	4	0	1
L:L:R7	R:R:I180	8.77	2	Yes	No	0	5	0	1
L:L:R7	R:R:E184	19.77	2	Yes	No	0	4	0	1
L:L:W8	R:R:E184	3.27	2	Yes	No	0	4	0	1
L:L:W8	R:R:I189	9.4	2	Yes	No	0	6	0	1
L:L:W8	R:R:L192	3.42	2	Yes	No	0	4	0	1
L:L:D9	R:R:F281	16.72	0	No	Yes	0	3	0	1
R:R:F45	R:R:I40	5.02	5	Yes	No	7	5	1	2
R:R:F45	R:R:T95	10.38	5	Yes	Yes	7	5	1	1
R:R:F45	R:R:M289	3.73	5	Yes	No	7	6	1	2
R:R:I124	R:R:N91	7.08	0	Yes	No	4	6	1	2
R:R:M289	R:R:N91	8.41	0	No	No	6	6	2	2
R:R:E94	R:R:F120	5.83	0	No	Yes	5	5	2	2
R:R:D121	R:R:E94	9.09	0	Yes	No	4	5	1	2
R:R:E94	R:R:I124	4.1	0	No	Yes	5	4	2	1
R:R:F120	R:R:M97	3.73	0	Yes	No	5	4	2	1
R:R:D110	R:R:E109	15.59	0	No	No	6	3	1	2
R:R:N118	R:R:Q114	3.96	2	No	No	4	5	1	2
R:R:D117	R:R:N118	5.39	2	Yes	No	3	4	1	1
R:R:I180	R:R:S122	7.74	0	No	No	5	4	1	2
R:R:C125	R:R:I180	3.27	0	Yes	No	4	5	2	1
R:R:I189	R:R:I266	2.94	0	No	No	6	3	1	2
R:R:F258	R:R:F259	4.29	6	No	No	5	6	1	2
R:R:F258	R:R:F281	5.36	6	No	Yes	5	3	1	1
R:R:H261	R:R:I265	6.63	0	Yes	No	5	3	2	1
R:R:F281	R:R:H261	12.44	6	Yes	Yes	3	5	1	2
R:R:F281	R:R:N282	3.62	6	Yes	No	3	3	1	2
R:R:I265	R:R:L262	2.85	0	No	No	3	5	1	2
L:L:F11	R:R:I265	2.51	0	No	No	0	3	0	1
R:R:P42	R:R:T95	1.75	0	No	Yes	4	5	2	1
R:R:I124	R:R:S90	1.55	0	Yes	No	4	5	1	2
R:R:L46	R:R:T95	1.47	0	No	Yes	5	5	2	1
R:R:I113	R:R:L106	1.43	0	No	No	8	5	1	2
R:R:H102	R:R:I98	1.33	0	No	No	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8Y_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.92
Number of Linked Nodes	248
Number of Links	267
Number of Hubs	33
Number of Links mediated by Hubs	132
Number of Communities	11
Number of Nodes involved in Communities	41
Number of Links involved in Communities	46

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	37992
Length Of Smallest Path	3
Average Path Length	13.0708
Length of Longest Path	28
Minimum Path Strength	1.285
Average Path Strength	6.5385
Maximum Path Strength	18.115
Minimum Path Correlation	0.7
Average Path Correlation	0.926838
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	46.676
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	43.8341
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of blood pressure • phospholipase C-activating G protein-coupled receptor signaling pathway • behavior • rhythmic process • circadian behavior • locomotory behavior • rhythmic behavior • circadian rhythm • locomotor rhythm • multicellular organismal-level homeostasis • homoiothermy • homeostatic process • temperature homeostasis • sodium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • regulation of biosynthetic process • circadian regulation of gene expression • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • skeletal system development • bone development • response to pH • cellular response to pH • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • positive regulation of biological process • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • G-protein beta-subunit binding • melanocortin receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • hormone activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide signaling pathway • regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • tumor necrosis factor production • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • negative regulation of multicellular organismal process • corticosterone secretion • regulation of glucocorticoid secretion • regulation of steroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • lipid localization • endocrine process • regulation of lipid localization • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of signal transduction • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of G protein-coupled receptor signaling pathway • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Gamma-MSH
UniProt	P01189
Sequence	>8W8Y_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>8W8Y_nogp_Chain_R V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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