psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:E94	4.87	No	Yes	1	0	5
2	I:I:?1	R:R:D117	7.49	No	Yes	1	0	3
3	I:I:?1	R:R:D121	9.98	No	Yes	1	0	4
4	L:L:R8	L:L:Y2	3.09	Yes	Yes	1	0	0
5	L:L:Y2	R:R:Q114	12.4	Yes	No	0	0	5
6	L:L:Y2	R:R:D117	10.34	Yes	Yes	1	0	3
7	L:L:M4	R:R:E94	5.41	Yes	Yes	0	0	5
8	L:L:M4	R:R:M97	5.78	Yes	No	0	0	4
9	L:L:M4	R:R:I98	5.83	Yes	No	0	0	4
10	L:L:M4	R:R:I113	4.37	Yes	No	0	0	8
11	L:L:M4	R:R:D117	12.48	Yes	Yes	0	0	3
12	L:L:E5	L:L:K11	4.05	No	No	0	0	0
13	L:L:H6	R:R:F45	11.31	No	Yes	2	0	7
14	L:L:H6	R:R:T95	5.48	No	No	2	0	5
15	L:L:H6	R:R:N282	8.93	No	No	0	0	3
16	L:L:F7	L:L:W9	4.01	Yes	Yes	0	0	0
17	L:L:F7	R:R:D121	4.78	Yes	Yes	0	0	4
18	L:L:F7	R:R:I124	8.79	Yes	No	0	0	4
19	L:L:F7	R:R:F258	5.36	Yes	Yes	0	0	5
20	L:L:F7	R:R:L285	4.87	Yes	No	0	0	3
21	L:L:R8	L:L:W9	4	Yes	Yes	1	0	0
22	L:L:R8	R:R:D117	5.96	Yes	Yes	1	0	3
23	L:L:R8	R:R:N118	8.44	Yes	No	0	0	4
24	L:L:R8	R:R:D121	16.68	Yes	Yes	1	0	4
25	L:L:R8	R:R:I180	6.26	Yes	No	0	0	5
26	L:L:R8	R:R:S183	5.27	Yes	No	1	0	5
27	L:L:W9	R:R:S183	9.88	Yes	No	1	0	5
28	L:L:W9	R:R:I189	5.87	Yes	No	1	0	6
29	L:L:W9	R:R:L192	3.42	Yes	No	0	0	4
30	L:L:W9	R:R:L262	3.42	Yes	Yes	1	0	5
31	L:L:G10	R:R:H261	3.18	No	Yes	3	0	5
32	L:L:G10	R:R:F281	9.03	No	Yes	3	0	3
33	L:L:P12	R:R:P269	3.9	No	No	0	0	2
34	R:R:I40	R:R:V44	3.07	No	No	2	5	4
35	R:R:F45	R:R:I40	5.02	Yes	No	2	7	5
36	R:R:I40	R:R:V286	3.07	No	No	2	5	5
37	R:R:E43	R:R:P42	4.72	No	No	0	3	4
38	R:R:V286	R:R:V44	3.21	No	No	2	5	4
39	R:R:F45	R:R:T95	10.38	Yes	No	2	7	5
40	R:R:F45	R:R:M289	4.98	Yes	Yes	0	7	6
41	R:R:L48	R:R:M289	4.24	No	Yes	0	6	6
42	R:R:C290	R:R:L48	3.17	No	No	0	5	6
43	R:R:G49	R:R:S88	3.71	No	Yes	0	6	8
44	R:R:S52	R:R:S88	6.52	No	Yes	4	7	8
45	R:R:S292	R:R:S52	3.26	No	No	4	9	7
46	R:R:E55	R:R:V293	4.28	Yes	No	0	7	5
47	R:R:E55	R:R:P296	7.86	Yes	No	0	7	9
48	R:R:E55	R:R:L297	3.98	Yes	No	0	7	5
49	R:R:A81	R:R:N56	3.13	No	No	0	9	9
50	R:R:D84	R:R:N56	6.73	Yes	No	0	9	9
51	R:R:N56	R:R:P296	4.89	No	No	0	9	9
52	R:R:I57	R:R:M85	5.83	No	No	0	4	6
53	R:R:F310	R:R:L58	7.31	No	No	0	7	7
54	R:R:A300	R:R:V59	3.39	No	No	0	8	9
55	R:R:A81	R:R:I60	3.25	No	No	0	9	8
56	R:R:A62	R:R:T309	3.36	No	No	0	8	8
57	R:R:C78	R:R:V63	5.12	No	No	0	7	8
58	R:R:H70	R:R:N66	8.93	No	No	0	8	7
59	R:R:N66	R:R:T309	10.24	No	No	0	7	8
60	R:R:G67	R:R:H70	6.35	No	No	0	5	8
61	R:R:L69	R:R:N68	12.36	No	No	0	8	7
62	R:R:H70	R:R:Y74	10.89	No	Yes	0	8	8
63	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
64	R:R:M156	R:R:P72	5.03	No	Yes	0	8	6
65	R:R:P72	R:R:V158	3.53	Yes	No	0	6	1
66	R:R:A161	R:R:P72	3.74	No	Yes	0	6	6
67	R:R:M73	R:R:Y74	8.38	No	Yes	0	8	8
68	R:R:S303	R:R:Y74	5.09	No	Yes	5	8	8
69	R:R:E305	R:R:Y74	4.49	No	Yes	0	6	8
70	R:R:L306	R:R:Y74	8.21	No	Yes	5	8	8
71	R:R:F75	R:R:V158	6.55	No	No	0	4	1
72	R:R:F75	R:R:L162	6.09	No	No	0	4	2
73	R:R:A137	R:R:F76	4.16	No	No	0	7	7
74	R:R:D141	R:R:F76	7.17	No	No	0	9	7
75	R:R:F76	R:R:I165	5.02	No	No	0	7	7
76	R:R:N134	R:R:S79	5.96	No	No	0	8	9
77	R:R:I165	R:R:S79	9.29	No	No	0	7	9
78	R:R:D84	R:R:L80	8.14	Yes	No	0	9	9
79	R:R:L135	R:R:L80	5.54	No	No	0	8	9
80	R:R:V82	R:R:W169	3.68	No	No	0	7	9
81	R:R:A83	R:R:S131	3.42	No	No	0	8	9
82	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
83	R:R:D84	R:R:S292	8.83	Yes	No	0	9	9
84	R:R:D295	R:R:D84	9.31	No	Yes	0	9	9
85	R:R:L86	R:R:S127	4.5	Yes	No	0	6	7
86	R:R:S127	R:R:V87	6.46	No	No	0	7	8
87	R:R:M289	R:R:S88	3.07	Yes	Yes	0	6	8
88	R:R:S292	R:R:S88	4.89	No	Yes	4	9	8
89	R:R:M123	R:R:S90	7.67	No	No	0	4	5
90	R:R:I124	R:R:N91	7.08	No	No	0	4	6
91	R:R:M289	R:R:N91	4.21	Yes	No	0	6	6
92	R:R:E94	R:R:F120	8.16	Yes	No	0	5	5
93	R:R:D121	R:R:E94	6.5	Yes	Yes	1	4	5
94	R:R:F120	R:R:M97	3.73	No	No	0	5	4
95	R:R:I100	R:R:V101	3.07	No	No	0	3	3
96	R:R:H102	R:R:S103	9.76	No	No	0	5	4
97	R:R:F112	R:R:T107	3.89	No	No	0	1	4
98	R:R:F108	R:R:Q111	3.51	No	No	0	3	2
99	R:R:F108	R:R:F112	3.22	No	No	0	3	1
100	R:R:D110	R:R:E109	14.29	No	No	0	6	3
101	R:R:H115	R:R:Q111	7.42	No	No	0	4	2
102	R:R:F112	R:R:M116	11.2	No	No	0	1	5
103	R:R:D117	R:R:D121	7.98	Yes	Yes	1	3	4
104	R:R:I180	R:R:S122	4.64	No	No	0	5	4
105	R:R:C125	R:R:G176	3.92	No	No	0	4	6
106	R:R:G173	R:R:I126	3.53	No	No	0	4	4
107	R:R:L128	R:R:W255	4.56	No	Yes	0	5	8
108	R:R:C172	R:R:V129	6.83	No	No	0	8	5
109	R:R:A130	R:R:W169	7.78	No	No	0	7	9
110	R:R:A130	R:R:C172	3.61	No	No	0	7	8
111	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
112	R:R:I132	R:R:M199	5.83	No	No	0	7	7
113	R:R:I132	R:R:W255	10.57	No	Yes	0	7	8
114	R:R:C133	R:R:C172	3.64	No	No	0	5	8
115	R:R:C133	R:R:M199	3.24	No	No	0	5	7
116	R:R:F251	R:R:L135	3.65	Yes	No	0	8	8
117	R:R:L135	R:R:Y299	4.69	No	Yes	0	8	9
118	R:R:L136	R:R:L202	6.92	No	No	0	7	5
119	R:R:I138	R:R:R142	3.76	No	No	8	8	9
120	R:R:I138	R:R:Y299	4.84	No	Yes	8	8	9
121	R:R:A139	R:R:Y207	5.34	No	Yes	0	8	9
122	R:R:D141	R:R:Y152	5.75	No	Yes	6	9	8
123	R:R:D141	R:R:M156	6.93	No	No	6	9	8
124	R:R:R142	R:R:Y207	8.23	No	Yes	0	9	9
125	R:R:R142	R:R:Y299	3.09	No	Yes	8	9	9
126	R:R:F147	R:R:Y143	13.41	Yes	Yes	9	6	8
127	R:R:L206	R:R:Y143	4.69	No	Yes	0	6	8
128	R:R:H209	R:R:Y143	7.62	No	Yes	9	6	8
129	R:R:M210	R:R:Y143	4.79	No	Yes	0	9	8
130	R:R:V144	R:R:Y152	5.05	No	Yes	0	6	8
131	R:R:I155	R:R:V144	3.07	No	No	0	5	6
132	R:R:I146	R:R:T145	3.04	No	No	0	9	8
133	R:R:T145	R:R:Y152	8.74	No	Yes	0	8	8
134	R:R:F147	R:R:I146	5.02	Yes	No	0	6	9
135	R:R:F147	R:R:H209	7.92	Yes	No	9	6	6
136	R:R:F147	R:R:F213	9.65	Yes	No	0	6	5
137	R:R:I155	R:R:R151	5.01	No	No	0	5	6
138	R:R:H153	R:R:Y152	6.53	No	Yes	0	5	8
139	R:R:M156	R:R:Y152	8.38	No	Yes	6	8	8
140	R:R:K160	R:R:T157	4.5	No	No	0	7	8
141	R:R:C175	R:R:F179	4.19	No	Yes	0	4	3
142	R:R:F179	R:R:V188	6.55	Yes	No	0	3	5
143	R:R:F179	R:R:L192	4.87	Yes	No	0	3	4
144	R:R:V181	R:R:Y182	6.31	No	No	0	2	5
145	R:R:K186	R:R:Y182	9.55	No	No	0	4	5
146	R:R:K186	R:R:V188	6.07	No	No	0	4	5
147	R:R:C191	R:R:M187	3.24	No	No	0	5	5
148	R:R:I189	R:R:L262	4.28	No	Yes	1	6	5
149	R:R:I189	R:R:I266	5.89	No	No	0	6	3
150	R:R:I193	R:R:L262	4.28	No	Yes	0	4	5
151	R:R:I193	R:R:V263	6.14	No	No	0	4	5
152	R:R:F196	R:R:F197	6.43	Yes	No	0	7	4
153	R:R:F196	R:R:M200	8.71	Yes	No	7	7	6
154	R:R:F196	R:R:F251	3.22	Yes	Yes	7	7	8
155	R:R:F196	R:R:F259	26.79	Yes	No	0	7	6
156	R:R:F251	R:R:M200	6.22	Yes	No	7	8	6
157	R:R:I252	R:R:M200	8.75	No	No	0	5	6
158	R:R:F251	R:R:M203	11.2	Yes	No	0	8	8
159	R:R:G204	R:R:L248	3.42	No	No	0	5	7
160	R:R:M210	R:R:Y207	4.79	No	Yes	0	9	9
161	R:R:L247	R:R:Y207	5.86	No	Yes	0	8	9
162	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
163	R:R:F211	R:R:R215	5.34	Yes	No	0	6	6
164	R:R:A241	R:R:F211	4.16	No	Yes	0	7	6
165	R:R:F213	R:R:H217	5.66	No	No	0	5	7
166	R:R:K219	R:R:R215	3.71	No	No	0	5	6
167	R:R:H217	R:R:R220	4.51	No	No	0	7	6
168	R:R:A241	R:R:M238	3.22	No	No	0	7	4
169	R:R:G240	R:R:T243	3.64	No	No	0	8	9
170	R:R:I244	R:R:L248	4.28	Yes	No	0	7	7
171	R:R:L247	R:R:Y299	4.69	No	Yes	0	8	9
172	R:R:F251	R:R:W255	6.01	Yes	Yes	0	8	8
173	R:R:C254	R:R:N291	6.3	No	No	0	8	9
174	R:R:I288	R:R:W255	8.22	No	Yes	0	6	8
175	R:R:N291	R:R:W255	13.56	No	Yes	0	9	8
176	R:R:P257	R:R:Y284	4.17	No	No	0	9	5
177	R:R:F258	R:R:F259	5.36	Yes	No	0	5	6
178	R:R:F258	R:R:L262	6.09	Yes	Yes	0	5	5
179	R:R:F258	R:R:F281	5.36	Yes	Yes	0	5	3
180	R:R:F258	R:R:I288	3.77	Yes	No	0	5	6
181	R:R:L260	R:R:Y277	4.69	No	No	0	5	1
182	R:R:H261	R:R:I265	7.95	Yes	No	3	5	3
183	R:R:H261	R:R:T278	6.85	Yes	No	3	5	3
184	R:R:F281	R:R:H261	11.31	Yes	Yes	3	3	5
185	R:R:T267	R:R:V263	3.17	No	No	0	4	5
186	R:R:L264	R:R:Y277	4.69	No	No	0	5	1
187	R:R:I265	R:R:T278	3.04	No	No	3	3	3
188	R:R:C268	R:R:T267	3.38	Yes	No	0	4	4
189	R:R:C268	R:R:N271	3.15	Yes	Yes	10	4	4
190	R:R:C268	R:R:C274	3.64	Yes	No	10	4	4
191	R:R:C274	R:R:N271	3.15	No	Yes	10	4	4
192	R:R:Y277	R:R:Y284	17.87	No	No	0	1	5
193	R:R:H280	R:R:T283	5.48	No	No	0	3	4
194	R:R:H280	R:R:Y284	6.53	No	No	0	3	5
195	R:R:F281	R:R:L285	8.53	Yes	No	0	3	3
196	R:R:D295	R:R:N291	12.12	No	No	0	9	9
197	R:R:I298	R:R:Y299	6.04	No	Yes	0	9	9
198	R:R:F301	R:R:R307	5.34	No	No	0	6	8
199	R:R:F301	R:R:F310	4.29	No	No	0	6	7
200	R:R:L306	R:R:S303	6.01	No	No	5	8	8
201	R:R:L304	R:R:R307	3.64	No	No	0	5	8
202	R:R:F211	R:R:G240	3.01	Yes	No	0	6	8
203	R:R:F253	R:R:G249	3.01	No	No	0	5	6
204	R:R:L86	R:R:S90	3	Yes	No	0	6	5
205	R:R:L306	R:R:V63	2.98	No	No	0	8	8
206	R:R:L136	R:R:V140	2.98	No	No	0	7	6
207	R:R:L264	R:R:T278	2.95	No	No	0	5	3
208	L:L:S1	R:R:D110	2.94	No	No	0	0	6
209	R:R:M116	R:R:M97	2.89	No	No	0	5	4
210	R:R:E55	R:R:V51	2.85	Yes	No	0	7	5
211	R:R:I57	R:R:L61	2.85	No	No	0	4	5
212	R:R:I126	R:R:L86	2.85	No	Yes	0	4	6
213	R:R:L53	R:R:M85	2.83	No	No	0	6	6
214	R:R:I168	R:R:N134	2.83	No	No	0	6	8
215	R:R:L136	R:R:M199	2.83	No	No	0	7	7
216	R:R:C125	R:R:F179	2.79	No	Yes	0	4	3
217	R:R:C191	R:R:F179	2.79	No	Yes	0	5	3
218	R:R:A256	R:R:F196	2.77	No	Yes	0	5	7
219	R:R:E43	R:R:K41	2.7	No	No	0	3	4
220	R:R:D104	R:R:H102	2.52	No	No	0	4	5
221	R:R:F211	R:R:I244	2.51	Yes	Yes	0	6	7
222	R:R:F179	R:R:M195	2.49	Yes	No	0	3	4
223	R:R:F75	R:R:L69	2.44	No	No	0	4	8
224	R:R:I155	R:R:Y148	2.42	No	No	0	5	5
225	R:R:I244	R:R:Y207	2.42	Yes	Yes	0	7	9
226	R:R:L77	R:R:Y74	2.34	No	Yes	0	8	8
227	R:R:L77	R:R:Y299	2.34	No	Yes	0	8	9
228	R:R:L86	R:R:W169	2.28	Yes	No	0	6	9
229	R:R:R302	R:R:R307	2.13	No	No	0	8	8
230	R:R:C268	R:R:P269	1.88	Yes	No	0	4	2
231	R:R:P296	R:R:V59	1.77	No	No	0	9	9
232	R:R:P42	R:R:T95	1.75	No	No	0	4	5
233	L:L:G10	L:L:K11	1.74	No	No	0	0	0
234	R:R:G240	R:R:K239	1.74	No	No	0	8	8
235	R:R:G249	R:R:L248	1.71	No	No	0	6	7
236	R:R:C254	R:R:V250	1.71	No	No	0	8	6
237	R:R:L287	R:R:P257	1.64	No	No	0	7	9
238	L:L:S1	L:L:S3	1.63	No	No	0	0	0
239	R:R:N271	R:R:P272	1.63	Yes	No	0	4	1
240	R:R:V166	R:R:V170	1.6	No	No	0	5	4
241	R:R:V174	R:R:V178	1.6	No	No	0	3	4
242	R:R:V177	R:R:V181	1.6	No	No	0	4	2
243	R:R:T107	R:R:V101	1.59	No	No	0	4	3
244	R:R:I50	R:R:V51	1.54	No	No	0	5	5
245	R:R:I60	R:R:V64	1.54	No	No	0	8	4
246	R:R:I266	R:R:V190	1.54	No	No	0	3	4
247	R:R:I246	R:R:V242	1.54	No	No	0	7	7
248	R:R:I294	R:R:V250	1.54	No	No	0	6	6
249	R:R:I193	R:R:T194	1.52	No	No	0	4	4
250	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
251	R:R:K160	R:R:T163	1.5	No	No	0	7	3
252	R:R:L53	R:R:V89	1.49	No	No	0	6	5
253	R:R:L93	R:R:V89	1.49	No	No	0	6	5
254	R:R:I246	R:R:I298	1.47	No	No	0	7	9
255	R:R:I60	R:R:M85	1.46	No	No	0	8	6
256	R:R:I119	R:R:M123	1.46	No	No	0	5	4
257	R:R:N271	R:R:T270	1.46	Yes	No	0	4	1
258	R:R:F39	R:R:P42	1.44	No	No	0	4	4
259	R:R:E184	R:R:S185	1.44	No	No	0	4	4
260	R:R:I96	R:R:L46	1.43	No	No	0	5	5
261	R:R:A62	R:R:F310	1.39	No	No	0	8	7
262	R:R:H153	R:R:S154	1.39	No	No	0	5	5
263	R:R:R65	R:R:T309	1.29	No	No	0	5	8
264	R:R:R159	R:R:T157	1.29	No	No	0	4	8
265	R:R:V178	R:R:Y182	1.26	No	No	0	4	5
266	R:R:F211	R:R:L212	1.22	Yes	No	0	6	3
267	L:L:Y2	R:R:D110	1.15	Yes	No	0	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	6.745	4	1	0
2	L:L:M4	6.774	5	0	0
3	L:L:F7	5.562	5	0	0
4	L:L:R8	7.1	7	1	0
5	L:L:W9	5.1	6	1	0
6	R:R:F45	7.9225	4	2	7
7	R:R:E55	4.7425	4	0	7
8	R:R:P72	3.965	4	0	6
9	R:R:Y74	6.56667	6	5	8
10	R:R:D84	7.486	5	0	9
11	R:R:L86	3.1575	4	0	6
12	R:R:S88	4.5475	4	4	8
13	R:R:E94	6.235	4	1	5
14	R:R:D117	8.85	5	1	3
15	R:R:D121	9.184	5	1	4
16	R:R:Y143	7.6275	4	9	8
17	R:R:F147	9	4	9	6
18	R:R:Y152	6.89	5	6	8
19	R:R:F179	3.94667	6	0	3
20	R:R:F196	9.584	5	7	7
21	R:R:Y207	5.328	5	0	9
22	R:R:F211	3.248	5	0	6
23	R:R:I244	2.76	5	0	7
24	R:R:F251	6.06	5	7	8
25	R:R:W255	7.97667	6	0	8
26	R:R:F258	5.188	5	0	5
27	R:R:H261	7.3225	4	3	5
28	R:R:L262	4.5175	4	1	5
29	R:R:C268	3.0125	4	10	4
30	R:R:N271	2.3475	4	10	4
31	R:R:F281	8.5575	4	3	3
32	R:R:M289	4.125	4	0	6
33	R:R:Y299	4.28167	6	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M4	R:R:M97	15.3024	5.78	Yes	No	0	0	4
2	L:L:M4	R:R:D117	10.6322	12.48	Yes	Yes	0	0	3
3	L:L:F7	R:R:D121	43.0065	4.78	Yes	Yes	0	0	4
4	L:L:F7	R:R:F258	61.3659	5.36	Yes	Yes	0	0	5
5	R:R:F258	R:R:F281	15.5659	5.36	Yes	Yes	0	5	3
6	L:L:R8	L:L:W9	16.8041	4	Yes	Yes	1	0	0
7	L:L:F7	L:L:W9	22.3655	4.01	Yes	Yes	0	0	0
8	L:L:W9	R:R:L192	24.3793	3.42	Yes	No	0	0	4
9	L:L:W9	R:R:L262	21.1744	3.42	Yes	Yes	1	0	5
10	R:R:F258	R:R:L262	30.9304	6.09	Yes	Yes	0	5	5
11	R:R:F281	R:R:H261	13.43	11.31	Yes	Yes	3	3	5
12	R:R:I193	R:R:L262	10.343	4.28	No	Yes	0	4	5
13	R:R:F258	R:R:I288	55.6439	3.77	Yes	No	0	5	6
14	R:R:I288	R:R:W255	55.7038	8.22	No	Yes	0	6	8
15	R:R:D84	R:R:N56	13.1087	6.73	Yes	No	0	9	9
16	R:R:F258	R:R:F259	42.4838	5.36	Yes	No	0	5	6
17	R:R:F196	R:R:F259	42.4773	26.79	Yes	No	0	7	6
18	R:R:F196	R:R:F251	42.1046	3.22	Yes	Yes	7	7	8
19	R:R:F251	R:R:L135	90.0512	3.65	Yes	No	0	8	8
20	R:R:L135	R:R:Y299	100	4.69	No	Yes	0	8	9
21	R:R:L77	R:R:Y299	20.3068	2.34	No	Yes	0	8	9
22	R:R:L77	R:R:Y74	19.332	2.34	No	Yes	0	8	8
23	R:R:H70	R:R:Y74	12.3889	10.89	No	Yes	0	8	8
24	R:R:H70	R:R:N66	10.3665	8.93	No	No	0	8	7
25	R:R:F251	R:R:W255	49.1999	6.01	Yes	Yes	0	8	8
26	R:R:R142	R:R:Y299	42.9915	3.09	No	Yes	8	9	9
27	R:R:R142	R:R:Y207	42.4838	8.23	No	Yes	0	9	9
28	R:R:M210	R:R:Y207	56.128	4.79	No	Yes	0	9	9
29	R:R:M210	R:R:Y143	54.4742	4.79	No	Yes	0	9	8
30	R:R:F147	R:R:Y143	49.5662	13.41	Yes	Yes	9	6	8
31	R:R:F147	R:R:I146	42.9615	5.02	Yes	No	0	6	9
32	R:R:I146	R:R:T145	41.2841	3.04	No	No	0	9	8
33	R:R:T145	R:R:Y152	39.6024	8.74	No	Yes	0	8	8
34	R:R:M156	R:R:Y152	15.4973	8.38	No	Yes	6	8	8
35	R:R:M156	R:R:P72	13.8842	5.03	No	Yes	0	8	6
36	R:R:L247	R:R:Y299	42.9894	4.69	No	Yes	0	8	9
37	R:R:L247	R:R:Y207	42.2653	5.86	No	Yes	0	8	9
38	R:R:D141	R:R:Y152	12.2111	5.75	No	Yes	6	9	8
39	R:R:D141	R:R:F76	10.5893	7.17	No	No	0	9	7
40	R:R:L135	R:R:L80	12.8387	5.54	No	No	0	8	9
41	R:R:D84	R:R:L80	12.3375	8.14	Yes	No	0	9	9
42	R:R:I132	R:R:W255	13.5114	10.57	No	Yes	0	7	8
43	R:R:I132	R:R:M199	12.8387	5.83	No	No	0	7	7
44	R:R:C133	R:R:M199	10.1052	3.24	No	No	0	5	7
45	R:R:M116	R:R:M97	20.0797	2.89	No	No	0	5	4
46	R:R:F112	R:R:M116	17.6782	11.2	No	No	0	1	5
47	L:L:Y2	R:R:D110	13.0401	1.15	Yes	No	0	0	6
48	R:R:F179	R:R:L192	22.8218	4.87	Yes	No	0	3	4
49	R:R:F179	R:R:V188	11.5148	6.55	Yes	No	0	3	5
50	R:R:I244	R:R:Y207	27.9676	2.42	Yes	Yes	0	7	9
51	R:R:F211	R:R:I244	15.8615	2.51	Yes	Yes	0	6	7
52	R:R:H261	R:R:T278	11.0649	6.85	Yes	No	3	5	3
53	R:R:D121	R:R:E94	18.5651	6.5	Yes	Yes	1	4	5
54	R:R:D117	R:R:D121	15.041	7.98	Yes	Yes	1	3	4
55	L:L:R8	L:L:Y2	14.2998	3.09	Yes	Yes	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
I:I:?1	R:R:E94	4.87	1	No	Yes	0	5	2	1
I:I:?1	R:R:D117	7.49	1	No	Yes	0	3	2	1
I:I:?1	R:R:D121	9.98	1	No	Yes	0	4	2	1
L:L:Y2	R:R:Q114	12.4	1	Yes	No	0	5	0	1
L:L:Y2	R:R:D117	10.34	1	Yes	Yes	0	3	0	1
L:L:M4	R:R:E94	5.41	0	Yes	Yes	0	5	0	1
L:L:M4	R:R:M97	5.78	0	Yes	No	0	4	0	1
L:L:M4	R:R:I98	5.83	0	Yes	No	0	4	0	1
L:L:M4	R:R:I113	4.37	0	Yes	No	0	8	0	1
L:L:M4	R:R:D117	12.48	0	Yes	Yes	0	3	0	1
L:L:H6	R:R:F45	11.31	2	No	Yes	0	7	0	1
L:L:H6	R:R:T95	5.48	2	No	No	0	5	0	1
L:L:H6	R:R:N282	8.93	2	No	No	0	3	0	1
L:L:F7	R:R:D121	4.78	0	Yes	Yes	0	4	0	1
L:L:F7	R:R:I124	8.79	0	Yes	No	0	4	0	1
L:L:F7	R:R:F258	5.36	0	Yes	Yes	0	5	0	1
L:L:F7	R:R:L285	4.87	0	Yes	No	0	3	0	1
L:L:R8	R:R:D117	5.96	1	Yes	Yes	0	3	0	1
L:L:R8	R:R:N118	8.44	1	Yes	No	0	4	0	1
L:L:R8	R:R:D121	16.68	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:I180	6.26	1	Yes	No	0	5	0	1
L:L:R8	R:R:S183	5.27	1	Yes	No	0	5	0	1
L:L:W9	R:R:S183	9.88	1	Yes	No	0	5	0	1
L:L:W9	R:R:I189	5.87	1	Yes	No	0	6	0	1
L:L:W9	R:R:L192	3.42	1	Yes	No	0	4	0	1
L:L:W9	R:R:L262	3.42	1	Yes	Yes	0	5	0	1
L:L:G10	R:R:H261	3.18	3	No	Yes	0	5	0	1
L:L:G10	R:R:F281	9.03	3	No	Yes	0	3	0	1
L:L:P12	R:R:P269	3.9	0	No	No	0	2	0	1
R:R:F45	R:R:I40	5.02	2	Yes	No	7	5	1	2
R:R:F45	R:R:T95	10.38	2	Yes	No	7	5	1	1
R:R:F45	R:R:M289	4.98	2	Yes	Yes	7	6	1	2
R:R:I124	R:R:N91	7.08	0	No	No	4	6	1	2
R:R:M289	R:R:N91	4.21	0	Yes	No	6	6	2	2
R:R:E94	R:R:F120	8.16	1	Yes	No	5	5	1	2
R:R:D121	R:R:E94	6.5	1	Yes	Yes	4	5	1	1
R:R:F120	R:R:M97	3.73	0	No	No	5	4	2	1
R:R:D110	R:R:E109	14.29	0	No	No	6	3	1	2
R:R:D117	R:R:D121	7.98	1	Yes	Yes	3	4	1	1
R:R:I180	R:R:S122	4.64	0	No	No	5	4	1	2
R:R:F179	R:R:L192	4.87	0	Yes	No	3	4	2	1
R:R:I189	R:R:L262	4.28	1	No	Yes	6	5	1	1
R:R:I189	R:R:I266	5.89	1	No	No	6	3	1	2
R:R:I193	R:R:L262	4.28	0	No	Yes	4	5	2	1
R:R:F258	R:R:F259	5.36	0	Yes	No	5	6	1	2
R:R:F258	R:R:L262	6.09	0	Yes	Yes	5	5	1	1
R:R:F258	R:R:F281	5.36	0	Yes	Yes	5	3	1	1
R:R:F258	R:R:I288	3.77	0	Yes	No	5	6	1	2
R:R:H261	R:R:I265	7.95	3	Yes	No	5	3	1	2
R:R:H261	R:R:T278	6.85	3	Yes	No	5	3	1	2
R:R:F281	R:R:H261	11.31	3	Yes	Yes	3	5	1	1
R:R:I265	R:R:T278	3.04	3	No	No	3	3	2	2
R:R:F281	R:R:L285	8.53	3	Yes	No	3	3	1	1
L:L:S1	R:R:D110	2.94	0	No	No	0	6	0	1
R:R:M116	R:R:M97	2.89	0	No	No	5	4	2	1
R:R:C268	R:R:P269	1.88	10	Yes	No	4	2	2	1
R:R:P42	R:R:T95	1.75	0	No	No	4	5	2	1
L:L:Y2	R:R:D110	1.15	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	246
Number of Links	267
Number of Hubs	33
Number of Links mediated by Hubs	133
Number of Communities	10
Number of Nodes involved in Communities	42
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	71137
Length Of Smallest Path	3
Average Path Length	15.3629
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	5.83912
Maximum Path Strength	17.75
Minimum Path Correlation	0.7
Average Path Correlation	0.926558
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	40.4015
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.4698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>8W8W_nogp_Chain_R V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8W8W_nogp.zip

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