psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	I:I:?1	R:R:E94	4.87	No	Yes	1	0	5
2	I:I:?1	R:R:D117	7.49	No	Yes	1	0	3
3	I:I:?1	R:R:D121	9.98	No	Yes	1	0	4
4	L:L:R8	L:L:Y2	3.09	Yes	Yes	1	0	0
5	L:L:Y2	R:R:Q114	12.4	Yes	No	0	0	5
6	L:L:Y2	R:R:D117	10.34	Yes	Yes	1	0	3
7	L:L:M4	R:R:E94	5.41	Yes	Yes	0	0	5
8	L:L:M4	R:R:M97	5.78	Yes	No	0	0	4
9	L:L:M4	R:R:I98	5.83	Yes	No	0	0	4
10	L:L:M4	R:R:I113	4.37	Yes	No	0	0	8
11	L:L:M4	R:R:D117	12.48	Yes	Yes	0	0	3
12	L:L:E5	L:L:K11	4.05	No	No	0	0	0
13	L:L:H6	R:R:F45	11.31	No	Yes	2	0	7
14	L:L:H6	R:R:T95	5.48	No	No	2	0	5
15	L:L:H6	R:R:N282	8.93	No	No	0	0	3
16	L:L:F7	L:L:W9	4.01	Yes	Yes	0	0	0
17	L:L:F7	R:R:D121	4.78	Yes	Yes	0	0	4
18	L:L:F7	R:R:I124	8.79	Yes	No	0	0	4
19	L:L:F7	R:R:F258	5.36	Yes	Yes	0	0	5
20	L:L:F7	R:R:L285	4.87	Yes	No	0	0	3
21	L:L:R8	L:L:W9	4	Yes	Yes	1	0	0
22	L:L:R8	R:R:D117	5.96	Yes	Yes	1	0	3
23	L:L:R8	R:R:N118	8.44	Yes	No	0	0	4
24	L:L:R8	R:R:D121	16.68	Yes	Yes	1	0	4
25	L:L:R8	R:R:I180	6.26	Yes	No	0	0	5
26	L:L:R8	R:R:S183	5.27	Yes	No	1	0	5
27	L:L:W9	R:R:S183	9.88	Yes	No	1	0	5
28	L:L:W9	R:R:I189	5.87	Yes	No	1	0	6
29	L:L:W9	R:R:L192	3.42	Yes	No	0	0	4
30	L:L:W9	R:R:L262	3.42	Yes	Yes	1	0	5
31	L:L:G10	R:R:H261	3.18	No	Yes	3	0	5
32	L:L:G10	R:R:F281	9.03	No	Yes	3	0	3
33	L:L:P12	R:R:P269	3.9	No	No	0	0	2
34	R:R:I40	R:R:V44	3.07	No	No	2	5	4
35	R:R:F45	R:R:I40	5.02	Yes	No	2	7	5
36	R:R:I40	R:R:V286	3.07	No	No	2	5	5
37	R:R:E43	R:R:P42	4.72	No	No	0	3	4
38	R:R:V286	R:R:V44	3.21	No	No	2	5	4
39	R:R:F45	R:R:T95	10.38	Yes	No	2	7	5
40	R:R:F45	R:R:M289	4.98	Yes	Yes	0	7	6
41	R:R:L48	R:R:M289	4.24	No	Yes	0	6	6
42	R:R:C290	R:R:L48	3.17	No	No	0	5	6
43	R:R:G49	R:R:S88	3.71	No	Yes	0	6	8
44	R:R:S52	R:R:S88	6.52	No	Yes	4	7	8
45	R:R:S292	R:R:S52	3.26	No	No	4	9	7
46	R:R:E55	R:R:V293	4.28	Yes	No	0	7	5
47	R:R:E55	R:R:P296	7.86	Yes	No	0	7	9
48	R:R:E55	R:R:L297	3.98	Yes	No	0	7	5
49	R:R:A81	R:R:N56	3.13	No	No	0	9	9
50	R:R:D84	R:R:N56	6.73	Yes	No	0	9	9
51	R:R:N56	R:R:P296	4.89	No	No	0	9	9
52	R:R:I57	R:R:M85	5.83	No	No	0	4	6
53	R:R:F310	R:R:L58	7.31	No	No	0	7	7
54	R:R:A300	R:R:V59	3.39	No	No	0	8	9
55	R:R:A81	R:R:I60	3.25	No	No	0	9	8
56	R:R:A62	R:R:T309	3.36	No	No	0	8	8
57	R:R:C78	R:R:V63	5.12	No	No	0	7	8
58	R:R:H70	R:R:N66	8.93	No	No	0	8	7
59	R:R:N66	R:R:T309	10.24	No	No	0	7	8
60	R:R:G67	R:R:H70	6.35	No	No	0	5	8
61	R:R:L69	R:R:N68	12.36	No	No	0	8	7
62	R:R:H70	R:R:Y74	10.89	No	Yes	0	8	8
63	R:R:P72	R:R:S71	3.56	Yes	No	0	6	7
64	R:R:M156	R:R:P72	5.03	No	Yes	0	8	6
65	R:R:P72	R:R:V158	3.53	Yes	No	0	6	1
66	R:R:A161	R:R:P72	3.74	No	Yes	0	6	6
67	R:R:M73	R:R:Y74	8.38	No	Yes	0	8	8
68	R:R:S303	R:R:Y74	5.09	No	Yes	5	8	8
69	R:R:E305	R:R:Y74	4.49	No	Yes	0	6	8
70	R:R:L306	R:R:Y74	8.21	No	Yes	5	8	8
71	R:R:F75	R:R:V158	6.55	No	No	0	4	1
72	R:R:F75	R:R:L162	6.09	No	No	0	4	2
73	R:R:A137	R:R:F76	4.16	No	No	0	7	7
74	R:R:D141	R:R:F76	7.17	No	No	0	9	7
75	R:R:F76	R:R:I165	5.02	No	No	0	7	7
76	R:R:N134	R:R:S79	5.96	No	No	0	8	9
77	R:R:I165	R:R:S79	9.29	No	No	0	7	9
78	R:R:D84	R:R:L80	8.14	Yes	No	0	9	9
79	R:R:L135	R:R:L80	5.54	No	No	0	8	9
80	R:R:V82	R:R:W169	3.68	No	No	0	7	9
81	R:R:A83	R:R:S131	3.42	No	No	0	8	9
82	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
83	R:R:D84	R:R:S292	8.83	Yes	No	0	9	9
84	R:R:D295	R:R:D84	9.31	No	Yes	0	9	9
85	R:R:L86	R:R:S127	4.5	Yes	No	0	6	7
86	R:R:S127	R:R:V87	6.46	No	No	0	7	8
87	R:R:M289	R:R:S88	3.07	Yes	Yes	0	6	8
88	R:R:S292	R:R:S88	4.89	No	Yes	4	9	8
89	R:R:M123	R:R:S90	7.67	No	No	0	4	5
90	R:R:I124	R:R:N91	7.08	No	No	0	4	6
91	R:R:M289	R:R:N91	4.21	Yes	No	0	6	6
92	R:R:E94	R:R:F120	8.16	Yes	No	0	5	5
93	R:R:D121	R:R:E94	6.5	Yes	Yes	1	4	5
94	R:R:F120	R:R:M97	3.73	No	No	0	5	4
95	R:R:I100	R:R:V101	3.07	No	No	0	3	3
96	R:R:H102	R:R:S103	9.76	No	No	0	5	4
97	R:R:F112	R:R:T107	3.89	No	No	0	1	4
98	R:R:F108	R:R:Q111	3.51	No	No	0	3	2
99	R:R:F108	R:R:F112	3.22	No	No	0	3	1
100	R:R:D110	R:R:E109	14.29	No	No	0	6	3
101	R:R:H115	R:R:Q111	7.42	No	No	0	4	2
102	R:R:F112	R:R:M116	11.2	No	No	0	1	5
103	R:R:D117	R:R:D121	7.98	Yes	Yes	1	3	4
104	R:R:I180	R:R:S122	4.64	No	No	0	5	4
105	R:R:C125	R:R:G176	3.92	No	No	0	4	6
106	R:R:G173	R:R:I126	3.53	No	No	0	4	4
107	R:R:L128	R:R:W255	4.56	No	Yes	0	5	8
108	R:R:C172	R:R:V129	6.83	No	No	0	8	5
109	R:R:A130	R:R:W169	7.78	No	No	0	7	9
110	R:R:A130	R:R:C172	3.61	No	No	0	7	8
111	R:R:S131	R:R:W255	4.94	No	Yes	0	9	8
112	R:R:I132	R:R:M199	5.83	No	No	0	7	7
113	R:R:I132	R:R:W255	10.57	No	Yes	0	7	8
114	R:R:C133	R:R:C172	3.64	No	No	0	5	8
115	R:R:C133	R:R:M199	3.24	No	No	0	5	7
116	R:R:F251	R:R:L135	3.65	Yes	No	0	8	8
117	R:R:L135	R:R:Y299	4.69	No	Yes	0	8	9
118	R:R:L136	R:R:L202	6.92	No	No	0	7	5
119	R:R:I138	R:R:R142	3.76	No	No	8	8	9
120	R:R:I138	R:R:Y299	4.84	No	Yes	8	8	9
121	R:R:A139	R:R:Y207	5.34	No	Yes	0	8	9
122	R:R:D141	R:R:Y152	5.75	No	Yes	6	9	8
123	R:R:D141	R:R:M156	6.93	No	No	6	9	8
124	R:R:R142	R:R:Y207	8.23	No	Yes	0	9	9
125	R:R:R142	R:R:Y299	3.09	No	Yes	8	9	9
126	R:R:F147	R:R:Y143	13.41	Yes	Yes	9	6	8
127	R:R:L206	R:R:Y143	4.69	No	Yes	0	6	8
128	R:R:H209	R:R:Y143	7.62	No	Yes	9	6	8
129	R:R:M210	R:R:Y143	4.79	No	Yes	0	9	8
130	R:R:V144	R:R:Y152	5.05	No	Yes	0	6	8
131	R:R:I155	R:R:V144	3.07	No	No	0	5	6
132	R:R:I146	R:R:T145	3.04	No	No	0	9	8
133	R:R:T145	R:R:Y152	8.74	No	Yes	0	8	8
134	R:R:F147	R:R:I146	5.02	Yes	No	0	6	9
135	R:R:F147	R:R:H209	7.92	Yes	No	9	6	6
136	R:R:F147	R:R:F213	9.65	Yes	No	0	6	5
137	R:R:I155	R:R:R151	5.01	No	No	0	5	6
138	R:R:H153	R:R:Y152	6.53	No	Yes	0	5	8
139	R:R:M156	R:R:Y152	8.38	No	Yes	6	8	8
140	R:R:K160	R:R:T157	4.5	No	No	0	7	8
141	R:R:C175	R:R:F179	4.19	No	Yes	0	4	3
142	R:R:F179	R:R:V188	6.55	Yes	No	0	3	5
143	R:R:F179	R:R:L192	4.87	Yes	No	0	3	4
144	R:R:V181	R:R:Y182	6.31	No	No	0	2	5
145	R:R:K186	R:R:Y182	9.55	No	No	0	4	5
146	R:R:K186	R:R:V188	6.07	No	No	0	4	5
147	R:R:C191	R:R:M187	3.24	No	No	0	5	5
148	R:R:I189	R:R:L262	4.28	No	Yes	1	6	5
149	R:R:I189	R:R:I266	5.89	No	No	0	6	3
150	R:R:I193	R:R:L262	4.28	No	Yes	0	4	5
151	R:R:I193	R:R:V263	6.14	No	No	0	4	5
152	R:R:F196	R:R:F197	6.43	Yes	No	0	7	4
153	R:R:F196	R:R:M200	8.71	Yes	No	7	7	6
154	R:R:F196	R:R:F251	3.22	Yes	Yes	7	7	8
155	R:R:F196	R:R:F259	26.79	Yes	No	0	7	6
156	R:R:F251	R:R:M200	6.22	Yes	No	7	8	6
157	R:R:I252	R:R:M200	8.75	No	No	0	5	6
158	R:R:F251	R:R:M203	11.2	Yes	No	0	8	8
159	R:R:G204	R:R:L248	3.42	No	No	0	5	7
160	R:R:M210	R:R:Y207	4.79	No	Yes	0	9	9
161	R:R:L247	R:R:Y207	5.86	No	Yes	0	8	9
162	R:R:I244	R:R:V208	3.07	Yes	No	0	7	3
163	R:R:F211	R:R:R215	5.34	Yes	No	0	6	6
164	R:R:A241	R:R:F211	4.16	No	Yes	0	7	6
165	R:R:F213	R:R:H217	5.66	No	No	0	5	7
166	R:R:K219	R:R:R215	3.71	No	No	0	5	6
167	R:R:H217	R:R:R220	4.51	No	No	0	7	6
168	R:R:A241	R:R:M238	3.22	No	No	0	7	4
169	R:R:G240	R:R:T243	3.64	No	No	0	8	9
170	R:R:I244	R:R:L248	4.28	Yes	No	0	7	7
171	R:R:L247	R:R:Y299	4.69	No	Yes	0	8	9
172	R:R:F251	R:R:W255	6.01	Yes	Yes	0	8	8
173	R:R:C254	R:R:N291	6.3	No	No	0	8	9
174	R:R:I288	R:R:W255	8.22	No	Yes	0	6	8
175	R:R:N291	R:R:W255	13.56	No	Yes	0	9	8
176	R:R:P257	R:R:Y284	4.17	No	No	0	9	5
177	R:R:F258	R:R:F259	5.36	Yes	No	0	5	6
178	R:R:F258	R:R:L262	6.09	Yes	Yes	0	5	5
179	R:R:F258	R:R:F281	5.36	Yes	Yes	0	5	3
180	R:R:F258	R:R:I288	3.77	Yes	No	0	5	6
181	R:R:L260	R:R:Y277	4.69	No	No	0	5	1
182	R:R:H261	R:R:I265	7.95	Yes	No	3	5	3
183	R:R:H261	R:R:T278	6.85	Yes	No	3	5	3
184	R:R:F281	R:R:H261	11.31	Yes	Yes	3	3	5
185	R:R:T267	R:R:V263	3.17	No	No	0	4	5
186	R:R:L264	R:R:Y277	4.69	No	No	0	5	1
187	R:R:I265	R:R:T278	3.04	No	No	3	3	3
188	R:R:C268	R:R:T267	3.38	Yes	No	0	4	4
189	R:R:C268	R:R:N271	3.15	Yes	Yes	10	4	4
190	R:R:C268	R:R:C274	3.64	Yes	No	10	4	4
191	R:R:C274	R:R:N271	3.15	No	Yes	10	4	4
192	R:R:Y277	R:R:Y284	17.87	No	No	0	1	5
193	R:R:H280	R:R:T283	5.48	No	No	0	3	4
194	R:R:H280	R:R:Y284	6.53	No	No	0	3	5
195	R:R:F281	R:R:L285	8.53	Yes	No	0	3	3
196	R:R:D295	R:R:N291	12.12	No	No	0	9	9
197	R:R:I298	R:R:Y299	6.04	No	Yes	0	9	9
198	R:R:F301	R:R:R307	5.34	No	No	0	6	8
199	R:R:F301	R:R:F310	4.29	No	No	0	6	7
200	R:R:L306	R:R:S303	6.01	No	No	5	8	8
201	R:R:L304	R:R:R307	3.64	No	No	0	5	8
202	R:R:F211	R:R:G240	3.01	Yes	No	0	6	8
203	R:R:F253	R:R:G249	3.01	No	No	0	5	6
204	R:R:L86	R:R:S90	3	Yes	No	0	6	5
205	R:R:L306	R:R:V63	2.98	No	No	0	8	8
206	R:R:L136	R:R:V140	2.98	No	No	0	7	6
207	R:R:L264	R:R:T278	2.95	No	No	0	5	3
208	L:L:S1	R:R:D110	2.94	No	No	0	0	6
209	R:R:M116	R:R:M97	2.89	No	No	0	5	4
210	R:R:E55	R:R:V51	2.85	Yes	No	0	7	5
211	R:R:I57	R:R:L61	2.85	No	No	0	4	5
212	R:R:I126	R:R:L86	2.85	No	Yes	0	4	6
213	R:R:L53	R:R:M85	2.83	No	No	0	6	6
214	R:R:I168	R:R:N134	2.83	No	No	0	6	8
215	R:R:L136	R:R:M199	2.83	No	No	0	7	7
216	R:R:C125	R:R:F179	2.79	No	Yes	0	4	3
217	R:R:C191	R:R:F179	2.79	No	Yes	0	5	3
218	R:R:A256	R:R:F196	2.77	No	Yes	0	5	7
219	R:R:E43	R:R:K41	2.7	No	No	0	3	4
220	R:R:D104	R:R:H102	2.52	No	No	0	4	5
221	R:R:F211	R:R:I244	2.51	Yes	Yes	0	6	7
222	R:R:F179	R:R:M195	2.49	Yes	No	0	3	4
223	R:R:F75	R:R:L69	2.44	No	No	0	4	8
224	R:R:I155	R:R:Y148	2.42	No	No	0	5	5
225	R:R:I244	R:R:Y207	2.42	Yes	Yes	0	7	9
226	R:R:L77	R:R:Y74	2.34	No	Yes	0	8	8
227	R:R:L77	R:R:Y299	2.34	No	Yes	0	8	9
228	R:R:L86	R:R:W169	2.28	Yes	No	0	6	9
229	R:R:R302	R:R:R307	2.13	No	No	0	8	8
230	R:R:C268	R:R:P269	1.88	Yes	No	0	4	2
231	R:R:P296	R:R:V59	1.77	No	No	0	9	9
232	R:R:P42	R:R:T95	1.75	No	No	0	4	5
233	L:L:G10	L:L:K11	1.74	No	No	0	0	0
234	R:R:G240	R:R:K239	1.74	No	No	0	8	8
235	R:R:G249	R:R:L248	1.71	No	No	0	6	7
236	R:R:C254	R:R:V250	1.71	No	No	0	8	6
237	R:R:L287	R:R:P257	1.64	No	No	0	7	9
238	L:L:S1	L:L:S3	1.63	No	No	0	0	0
239	R:R:N271	R:R:P272	1.63	Yes	No	0	4	1
240	R:R:V166	R:R:V170	1.6	No	No	0	5	4
241	R:R:V174	R:R:V178	1.6	No	No	0	3	4
242	R:R:V177	R:R:V181	1.6	No	No	0	4	2
243	R:R:T107	R:R:V101	1.59	No	No	0	4	3
244	R:R:I50	R:R:V51	1.54	No	No	0	5	5
245	R:R:I60	R:R:V64	1.54	No	No	0	8	4
246	R:R:I266	R:R:V190	1.54	No	No	0	3	4
247	R:R:I246	R:R:V242	1.54	No	No	0	7	7
248	R:R:I294	R:R:V250	1.54	No	No	0	6	6
249	R:R:I193	R:R:T194	1.52	No	No	0	4	4
250	R:R:I244	R:R:T245	1.52	Yes	No	0	7	6
251	R:R:K160	R:R:T163	1.5	No	No	0	7	3
252	R:R:L53	R:R:V89	1.49	No	No	0	6	5
253	R:R:L93	R:R:V89	1.49	No	No	0	6	5
254	R:R:I246	R:R:I298	1.47	No	No	0	7	9
255	R:R:I60	R:R:M85	1.46	No	No	0	8	6
256	R:R:I119	R:R:M123	1.46	No	No	0	5	4
257	R:R:N271	R:R:T270	1.46	Yes	No	0	4	1
258	R:R:F39	R:R:P42	1.44	No	No	0	4	4
259	R:R:E184	R:R:S185	1.44	No	No	0	4	4
260	R:R:I96	R:R:L46	1.43	No	No	0	5	5
261	R:R:A62	R:R:F310	1.39	No	No	0	8	7
262	R:R:H153	R:R:S154	1.39	No	No	0	5	5
263	R:R:R65	R:R:T309	1.29	No	No	0	5	8
264	R:R:R159	R:R:T157	1.29	No	No	0	4	8
265	R:R:V178	R:R:Y182	1.26	No	No	0	4	5
266	R:R:F211	R:R:L212	1.22	Yes	No	0	6	3
267	L:L:Y2	R:R:D110	1.15	Yes	No	0	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:Y2	6.745	4	1	0
2	L:L:M4	6.774	5	0	0
3	L:L:F7	5.562	5	0	0
4	L:L:R8	7.1	7	1	0
5	L:L:W9	5.1	6	1	0
6	R:R:F45	7.9225	4	2	7
7	R:R:E55	4.7425	4	0	7
8	R:R:P72	3.965	4	0	6
9	R:R:Y74	6.56667	6	5	8
10	R:R:D84	7.486	5	0	9
11	R:R:L86	3.1575	4	0	6
12	R:R:S88	4.5475	4	4	8
13	R:R:E94	6.235	4	1	5
14	R:R:D117	8.85	5	1	3
15	R:R:D121	9.184	5	1	4
16	R:R:Y143	7.6275	4	9	8
17	R:R:F147	9	4	9	6
18	R:R:Y152	6.89	5	6	8
19	R:R:F179	3.94667	6	0	3
20	R:R:F196	9.584	5	7	7
21	R:R:Y207	5.328	5	0	9
22	R:R:F211	3.248	5	0	6
23	R:R:I244	2.76	5	0	7
24	R:R:F251	6.06	5	7	8
25	R:R:W255	7.97667	6	0	8
26	R:R:F258	5.188	5	0	5
27	R:R:H261	7.3225	4	3	5
28	R:R:L262	4.5175	4	1	5
29	R:R:C268	3.0125	4	10	4
30	R:R:N271	2.3475	4	10	4
31	R:R:F281	8.5575	4	3	3
32	R:R:M289	4.125	4	0	6
33	R:R:Y299	4.28167	6	8	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M4	R:R:M97	15.3024	5.78	Yes	No	0	0	4
2	L:L:M4	R:R:D117	10.6322	12.48	Yes	Yes	0	0	3
3	L:L:F7	R:R:D121	43.0065	4.78	Yes	Yes	0	0	4
4	L:L:F7	R:R:F258	61.3659	5.36	Yes	Yes	0	0	5
5	R:R:F258	R:R:F281	15.5659	5.36	Yes	Yes	0	5	3
6	L:L:R8	L:L:W9	16.8041	4	Yes	Yes	1	0	0
7	L:L:F7	L:L:W9	22.3655	4.01	Yes	Yes	0	0	0
8	L:L:W9	R:R:L192	24.3793	3.42	Yes	No	0	0	4
9	L:L:W9	R:R:L262	21.1744	3.42	Yes	Yes	1	0	5
10	R:R:F258	R:R:L262	30.9304	6.09	Yes	Yes	0	5	5
11	R:R:F281	R:R:H261	13.43	11.31	Yes	Yes	3	3	5
12	R:R:I193	R:R:L262	10.343	4.28	No	Yes	0	4	5
13	R:R:F258	R:R:I288	55.6439	3.77	Yes	No	0	5	6
14	R:R:I288	R:R:W255	55.7038	8.22	No	Yes	0	6	8
15	R:R:D84	R:R:N56	13.1087	6.73	Yes	No	0	9	9
16	R:R:F258	R:R:F259	42.4838	5.36	Yes	No	0	5	6
17	R:R:F196	R:R:F259	42.4773	26.79	Yes	No	0	7	6
18	R:R:F196	R:R:F251	42.1046	3.22	Yes	Yes	7	7	8
19	R:R:F251	R:R:L135	90.0512	3.65	Yes	No	0	8	8
20	R:R:L135	R:R:Y299	100	4.69	No	Yes	0	8	9
21	R:R:L77	R:R:Y299	20.3068	2.34	No	Yes	0	8	9
22	R:R:L77	R:R:Y74	19.332	2.34	No	Yes	0	8	8
23	R:R:H70	R:R:Y74	12.3889	10.89	No	Yes	0	8	8
24	R:R:H70	R:R:N66	10.3665	8.93	No	No	0	8	7
25	R:R:F251	R:R:W255	49.1999	6.01	Yes	Yes	0	8	8
26	R:R:R142	R:R:Y299	42.9915	3.09	No	Yes	8	9	9
27	R:R:R142	R:R:Y207	42.4838	8.23	No	Yes	0	9	9
28	R:R:M210	R:R:Y207	56.128	4.79	No	Yes	0	9	9
29	R:R:M210	R:R:Y143	54.4742	4.79	No	Yes	0	9	8
30	R:R:F147	R:R:Y143	49.5662	13.41	Yes	Yes	9	6	8
31	R:R:F147	R:R:I146	42.9615	5.02	Yes	No	0	6	9
32	R:R:I146	R:R:T145	41.2841	3.04	No	No	0	9	8
33	R:R:T145	R:R:Y152	39.6024	8.74	No	Yes	0	8	8
34	R:R:M156	R:R:Y152	15.4973	8.38	No	Yes	6	8	8
35	R:R:M156	R:R:P72	13.8842	5.03	No	Yes	0	8	6
36	R:R:L247	R:R:Y299	42.9894	4.69	No	Yes	0	8	9
37	R:R:L247	R:R:Y207	42.2653	5.86	No	Yes	0	8	9
38	R:R:D141	R:R:Y152	12.2111	5.75	No	Yes	6	9	8
39	R:R:D141	R:R:F76	10.5893	7.17	No	No	0	9	7
40	R:R:L135	R:R:L80	12.8387	5.54	No	No	0	8	9
41	R:R:D84	R:R:L80	12.3375	8.14	Yes	No	0	9	9
42	R:R:I132	R:R:W255	13.5114	10.57	No	Yes	0	7	8
43	R:R:I132	R:R:M199	12.8387	5.83	No	No	0	7	7
44	R:R:C133	R:R:M199	10.1052	3.24	No	No	0	5	7
45	R:R:M116	R:R:M97	20.0797	2.89	No	No	0	5	4
46	R:R:F112	R:R:M116	17.6782	11.2	No	No	0	1	5
47	L:L:Y2	R:R:D110	13.0401	1.15	Yes	No	0	0	6
48	R:R:F179	R:R:L192	22.8218	4.87	Yes	No	0	3	4
49	R:R:F179	R:R:V188	11.5148	6.55	Yes	No	0	3	5
50	R:R:I244	R:R:Y207	27.9676	2.42	Yes	Yes	0	7	9
51	R:R:F211	R:R:I244	15.8615	2.51	Yes	Yes	0	6	7
52	R:R:H261	R:R:T278	11.0649	6.85	Yes	No	3	5	3
53	R:R:D121	R:R:E94	18.5651	6.5	Yes	Yes	1	4	5
54	R:R:D117	R:R:D121	15.041	7.98	Yes	Yes	1	3	4
55	L:L:R8	L:L:Y2	14.2998	3.09	Yes	Yes	1	0	0

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
I:I:?1	R:R:E94	4.87	1	No	Yes	0	5	2	1
I:I:?1	R:R:D117	7.49	1	No	Yes	0	3	2	1
I:I:?1	R:R:D121	9.98	1	No	Yes	0	4	2	1
L:L:Y2	R:R:Q114	12.4	1	Yes	No	0	5	0	1
L:L:Y2	R:R:D117	10.34	1	Yes	Yes	0	3	0	1
L:L:M4	R:R:E94	5.41	0	Yes	Yes	0	5	0	1
L:L:M4	R:R:M97	5.78	0	Yes	No	0	4	0	1
L:L:M4	R:R:I98	5.83	0	Yes	No	0	4	0	1
L:L:M4	R:R:I113	4.37	0	Yes	No	0	8	0	1
L:L:M4	R:R:D117	12.48	0	Yes	Yes	0	3	0	1
L:L:H6	R:R:F45	11.31	2	No	Yes	0	7	0	1
L:L:H6	R:R:T95	5.48	2	No	No	0	5	0	1
L:L:H6	R:R:N282	8.93	2	No	No	0	3	0	1
L:L:F7	R:R:D121	4.78	0	Yes	Yes	0	4	0	1
L:L:F7	R:R:I124	8.79	0	Yes	No	0	4	0	1
L:L:F7	R:R:F258	5.36	0	Yes	Yes	0	5	0	1
L:L:F7	R:R:L285	4.87	0	Yes	No	0	3	0	1
L:L:R8	R:R:D117	5.96	1	Yes	Yes	0	3	0	1
L:L:R8	R:R:N118	8.44	1	Yes	No	0	4	0	1
L:L:R8	R:R:D121	16.68	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:I180	6.26	1	Yes	No	0	5	0	1
L:L:R8	R:R:S183	5.27	1	Yes	No	0	5	0	1
L:L:W9	R:R:S183	9.88	1	Yes	No	0	5	0	1
L:L:W9	R:R:I189	5.87	1	Yes	No	0	6	0	1
L:L:W9	R:R:L192	3.42	1	Yes	No	0	4	0	1
L:L:W9	R:R:L262	3.42	1	Yes	Yes	0	5	0	1
L:L:G10	R:R:H261	3.18	3	No	Yes	0	5	0	1
L:L:G10	R:R:F281	9.03	3	No	Yes	0	3	0	1
L:L:P12	R:R:P269	3.9	0	No	No	0	2	0	1
R:R:F45	R:R:I40	5.02	2	Yes	No	7	5	1	2
R:R:F45	R:R:T95	10.38	2	Yes	No	7	5	1	1
R:R:F45	R:R:M289	4.98	2	Yes	Yes	7	6	1	2
R:R:I124	R:R:N91	7.08	0	No	No	4	6	1	2
R:R:M289	R:R:N91	4.21	0	Yes	No	6	6	2	2
R:R:E94	R:R:F120	8.16	1	Yes	No	5	5	1	2
R:R:D121	R:R:E94	6.5	1	Yes	Yes	4	5	1	1
R:R:F120	R:R:M97	3.73	0	No	No	5	4	2	1
R:R:D110	R:R:E109	14.29	0	No	No	6	3	1	2
R:R:D117	R:R:D121	7.98	1	Yes	Yes	3	4	1	1
R:R:I180	R:R:S122	4.64	0	No	No	5	4	1	2
R:R:F179	R:R:L192	4.87	0	Yes	No	3	4	2	1
R:R:I189	R:R:L262	4.28	1	No	Yes	6	5	1	1
R:R:I189	R:R:I266	5.89	1	No	No	6	3	1	2
R:R:I193	R:R:L262	4.28	0	No	Yes	4	5	2	1
R:R:F258	R:R:F259	5.36	0	Yes	No	5	6	1	2
R:R:F258	R:R:L262	6.09	0	Yes	Yes	5	5	1	1
R:R:F258	R:R:F281	5.36	0	Yes	Yes	5	3	1	1
R:R:F258	R:R:I288	3.77	0	Yes	No	5	6	1	2
R:R:H261	R:R:I265	7.95	3	Yes	No	5	3	1	2
R:R:H261	R:R:T278	6.85	3	Yes	No	5	3	1	2
R:R:F281	R:R:H261	11.31	3	Yes	Yes	3	5	1	1
R:R:I265	R:R:T278	3.04	3	No	No	3	3	2	2
R:R:F281	R:R:L285	8.53	3	Yes	No	3	3	1	1
L:L:S1	R:R:D110	2.94	0	No	No	0	6	0	1
R:R:M116	R:R:M97	2.89	0	No	No	5	4	2	1
R:R:C268	R:R:P269	1.88	10	Yes	No	4	2	2	1
R:R:P42	R:R:T95	1.75	0	No	No	4	5	2	1
L:L:Y2	R:R:D110	1.15	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8W8W_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.04
Number of Linked Nodes	246
Number of Links	267
Number of Hubs	33
Number of Links mediated by Hubs	133
Number of Communities	10
Number of Nodes involved in Communities	42
Number of Links involved in Communities	49

Path Summary
Number Of Nodes in MetaPath	56
Number Of Links MetaPath	55
Number of Shortest Paths	71137
Length Of Smallest Path	3
Average Path Length	15.3629
Length of Longest Path	30
Minimum Path Strength	1.43
Average Path Strength	5.83912
Maximum Path Strength	17.75
Minimum Path Correlation	0.7
Average Path Correlation	0.926558
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	40.4015
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	48.4698
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • heart process • multicellular organismal process • system process • regulation of heart contraction • regulation of system process • circulatory system process • regulation of blood circulation • regulation of multicellular organismal process • regulation of biological quality • heart contraction • blood circulation • regulation of heart rate • regulation of blood pressure • phospholipase C-activating G protein-coupled receptor signaling pathway • behavior • rhythmic process • circadian behavior • locomotory behavior • rhythmic behavior • circadian rhythm • locomotor rhythm • multicellular organismal-level homeostasis • homoiothermy • homeostatic process • temperature homeostasis • sodium ion homeostasis • inorganic ion homeostasis • chemical homeostasis • monoatomic ion homeostasis • monoatomic cation homeostasis • regulation of behavior • feeding behavior • regulation of feeding behavior • regulation of biosynthetic process • circadian regulation of gene expression • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • regulation of gene expression • biosynthetic process • regulation of macromolecule biosynthetic process • metabolic process • macromolecule metabolic process • regulation of metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cell population proliferation • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to monoamine stimulus • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • signaling receptor binding • melanocortin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 1 melanocortin receptor binding • type 3 melanocortin receptor binding • type 4 melanocortin receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide signaling pathway • regulation of tumor necrosis factor production • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • tumor necrosis factor production • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • negative regulation of multicellular organismal process • regulation of localization • corticosterone secretion • regulation of glucocorticoid secretion • localization • regulation of steroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • lipid export from cell • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of corticosterone secretion • regulation of hormone secretion • transport • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • hormone secretion • secretion by cell • regulation of secretion by cell • signal release • regulation of signaling • secretion • regulation of transport • lipid localization • export from cell • cell-cell signaling • endocrine process • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • carbohydrate metabolic process • energy derivation by oxidation of organic compounds • glycogen metabolic process • primary metabolic process • regulation of generation of precursor metabolites and energy • generation of precursor metabolites and energy • regulation of polysaccharide metabolic process • regulation of primary metabolic process • glucan metabolic process • polysaccharide metabolic process • energy reserve metabolic process • regulation of glycogen metabolic process • regulation of carbohydrate metabolic process • intracellular signal transduction • calcium-mediated signaling • intracellular signaling cassette • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • regulation of G protein-coupled receptor signaling pathway • positive regulation of cellular process • positive regulation of G protein-coupled receptor signaling pathway • regulation of response to stimulus • regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway • positive regulation of signaling • pigmentation • cellular pigmentation • response to nutrient levels • regulation of appetite • response to peptide hormone • response to melanocyte-stimulating hormone • oxytocin production • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of oxytocin production • positive regulation of gene expression • positive regulation of oxytocin production • positive regulation of DNA-templated transcription • RNA metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • glucose homeostasis • carbohydrate homeostasis • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • secretory granule • secretory vesicle • vesicle • extracellular region • vesicle lumen • membrane-enclosed lumen • cytoplasmic vesicle lumen • secretory granule lumen • intracellular organelle lumen • organelle lumen • extracellular space • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • sensory perception of smell • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of peptide secretion • regulation of peptide transport • regulation of establishment of protein localization • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • regulation of insulin secretion involved in cellular response to glucose stimulus • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CA
PDB Residues	I:I:?1
Environment Details	Open EMBL-EBI Page
Code	CA
Name	CALCIUM ION
Synonyms
Identifier
Formula	Ca
Molecular Weight	40.078
SMILES
PubChem
Formal Charge	2
Total Atoms	1
Total Chiral Atoms	0
Total Bonds	0
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	L
Protein	Alpha-MSH
UniProt	P01189
Sequence	>8W8W_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	R
Protein	Receptor
UniProt	P41968
Sequence	>8W8W_nogp_Chain_R V F I K P E V F L S L G I V S L L E N I L V I L A V V R N G N L H S P M Y F F L C S L A V A D M L V S V S N A L E T I M I A I V H S D Y L T F E D Q F I Q H M D N I F D S M I C I S L V A S I C N L L A I A V D R Y V T I F Y A L R Y H S I M T V R K A L T L I V A I W V C C G V C G V V F I V Y S E S K M V I V C L I T M F F A M M L L M G T L Y V H M F L F A R L H V K R I A A L M K G A V T I T I L L G V F I F C W A P F F L H L V L I I T C P T N P Y C I C Y T A H F N T Y L V L I M C N S V I D P L I Y A F R S L E L R N T F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IOC	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	chim(NtGi1-Gs)/β1/γ2	2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8IOC (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.86	2023-09-20	doi.org/10.1038/s41421-023-00586-4
	8KIG	A	Peptide	Melanocortin	MC₃	Homo sapiens	SHU9119	Ca	-	3.1	2025-02-26	doi.org/10.2210/pdb8KIG/pdb
	8W8W	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8W (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	α-MSH	Ca		2.9	2025-03-19	To be published
	8W8X	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8X (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	β-MSH	Ca		2.9	2025-03-19	To be published
	8W8Y	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca	Gs/β1/γ2	2.9	2025-03-19	To be published
	8W8Y (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	γ-MSH	Ca		2.9	2025-03-19	To be published
	9K3F	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3F (No Gprot)	A	Peptide	Melanocortin	MC₃	Homo sapiens	-	-		2.75	2025-08-06	doi.org/10.1016/j.str.2025.03.004

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.