Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 8.0825404
2A:A:H41 6.3125406
3A:A:S51 3.055409
4A:A:F219 6.8675408
5A:A:H220 7.732517
6A:A:F222 11.376517
7A:A:Q227 4.944519
8A:A:R228 7.348519
9A:A:K233 6.75857719
10A:A:F246 4.132529
11A:A:R265 10.334179
12A:A:F273 6.34143729
13A:A:W277 6.97857726
14A:A:W281 10.846515
15A:A:L282 74169
16A:A:L289 6.2725429
17A:A:F290 8.3545129
18A:A:N292 4.7175409
19A:A:I308 5.685407
20A:A:F312 5.5785198
21A:A:P321 4.49525
22A:A:E330 5.468503
23A:A:D331 7.3925404
24A:A:V334 2.6625404
25A:A:K338 6.6825425
26A:A:Y339 7.385623
27A:A:R342 6.314524
28A:A:E344 8.27754195
29A:A:F345 8.452528
30A:A:L346 4.986524
31A:A:S349 4.52427
32A:A:Y358 8.2475444
33A:A:C359 4.182525
34A:A:Y360 7.135648
35A:A:R374 9.4954124
36A:A:I383 4.55754158
37A:A:R385 9.1875445
38A:A:L388 4.2554208
39A:A:Y391 8.374504
40B:B:L7 2.765408
41B:B:R48 3.04457
42B:B:L51 6.765409
43B:B:H54 10.0865229
44B:B:K57 11.442519
45B:B:M61 4.715406
46B:B:W63 10.02407
47B:B:Q75 9.7975419
48B:B:L79 4.7665237
49B:B:I81 6.305497
50B:B:W82 10.255409
51B:B:N88 6.1385147
52B:B:K89 12.64409
53B:B:H91 7.7475495
54B:B:I93 5.5407
55B:B:W99 8.425619
56B:B:M101 5.68409
57B:B:Y105 5.726596
58B:B:Y111 6.04504
59B:B:L117 6.725419
60B:B:C121 3.7375418
61B:B:L126 4.85495
62B:B:H142 8.9475419
63B:B:Y145 6.14714718
64B:B:F151 6.125409
65B:B:T159 7.22419
66B:B:D163 8.084519
67B:B:W169 10.0486718
68B:B:T173 4.75405
69B:B:F180 9.83437
70B:B:H183 8.508539
71B:B:D186 6.5825419
72B:B:V187 5.0225439
73B:B:M188 4.515418
74B:B:L190 6.5025435
75B:B:F199 7.008539
76B:B:V200 10.19416
77B:B:S201 4.2975439
78B:B:C204 4.745417
79B:B:K209 13.1025436
80B:B:L210 6.24405
81B:B:W211 8.71143738
82B:B:Q220 8.2625417
83B:B:F222 9.255418
84B:B:H225 9.86667619
85B:B:D228 7.534519
86B:B:F234 6.126505
87B:B:F235 7.118577106
88B:B:F241 10.354516
89B:B:D247 7.218519
90B:B:T249 6.955416
91B:B:R251 12.775418
92B:B:F253 7.526516
93B:B:R256 9.0775409
94B:B:D258 11.96417
95B:B:Q259 5.62406
96B:B:Y264 4.60333605
97B:B:R283 8.74409
98B:B:L285 4.8375406
99B:B:Y289 8.365607
100B:B:N295 7.7754136
101B:B:D298 10.364219
102B:B:V307 4.0845133
103B:B:H311 8.054569
104B:B:R314 15.0225418
105B:B:M325 5.3875455
106B:B:V327 4.33406
107B:B:W332 8.48167619
108B:B:K337 5.394566
109B:B:W339 10.944569
110G:G:L19 3.8575409
111G:G:Y40 7.99754106
112G:G:D48 6.6075459
113G:G:P49 4.38457
114G:G:V54 4.0125456
115G:G:N59 4.14459
116G:G:F61 5.44571758
117R:R:L53 2.555405
118R:R:P72 3.656577
119R:R:Y74 7.2354278
120R:R:D84 5.4425409
121R:R:S88 4.2354269
122R:R:N91 9.6454257
123R:R:I120 5.88405
124R:R:I123 5.31404
125R:R:F134 8.3225118
126R:R:R142 9.74489
127R:R:Y143 11.1975447
128R:R:I146 6.0725408
129R:R:F147 9.76446
130R:R:Y152 7.708578
131R:R:L158 7.265473
132R:R:W169 6.8045119
133R:R:F179 9.6554285
134R:R:I180 9.75754285
135R:R:H185 3.5325404
136R:R:L189 4.425404
137R:R:Y207 5.27833688
138R:R:L211 2.62406
139R:R:R213 6.5725446
140R:R:H217 7.28448
141R:R:T242 5.62409
142R:R:L247 3.1325407
143R:R:F250 9.3054298
144R:R:W254 9.498336297
145R:R:F258 7.8975405
146R:R:H260 14.0125404
147R:R:F277 10.14403
148R:R:Y298 5.09625889
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:I81 B:B:L126 14.1674.28YesYes975
2B:B:L126 B:B:Y105 28.28684.69YesYes956
3B:B:L69 B:B:Y105 30.17075.86NoYes056
4B:B:D66 B:B:L69 30.63479.5NoNo085
5B:B:D66 B:B:R68 31.09793.57NoNo085
6B:B:L126 B:B:V133 13.67864.47YesNo054
7B:B:I58 B:B:S316 10.34453.1NoNo099
8B:B:S316 B:B:W332 77.66546.18NoYes099
9A:A:D240 A:A:Y37 17.02523.45NoYes064
10A:A:Y37 B:B:D76 28.01515.75YesNo049
11B:B:D76 B:B:L55 27.68866.79NoNo096
12B:B:K57 B:B:W332 24.976212.76YesYes199
13A:A:D240 B:B:K57 11.851212.44NoYes169
14A:A:K34 B:B:L55 26.37998.46NoNo046
15A:A:K34 A:A:R38 25.725514.85NoNo044
16A:A:R42 A:A:Y37 12.379616.46NoYes094
17B:B:K57 B:B:W99 25.47724.64YesYes199
18A:A:F222 A:A:R42 11.72417.48YesNo179
19A:A:R38 R:R:H153 25.398411.28NoNo045
20A:A:Y391 R:R:I146 69.96464.84YesYes048
21A:A:L388 R:R:I146 67.65067.14YesYes088
22A:A:L388 A:A:L394 72.83114.15YesNo088
23A:A:L394 A:A:R389 98.97312.43NoNo084
24A:A:R356 A:A:R389 99.14084.26NoNo024
25A:A:R356 A:A:T284 99.48281.29NoNo024
26A:A:R283 A:A:T284 99.65481.29NoNo034
27A:A:R280 A:A:R283 99.82726.4NoNo053
28A:A:R280 A:A:W281 10019.99NoYes055
29A:A:W281 B:B:R314 34.583512YesYes158
30B:B:R314 B:B:W332 40.033315.99YesYes189
31A:A:L394 R:R:H217 38.83613.86NoYes088
32A:A:R385 R:R:H217 38.723812.41YesYes458
33A:A:R385 A:A:Y360 36.86088.23YesYes458
34A:A:D378 A:A:Y360 35.172714.94NoYes078
35A:A:F238 B:B:W99 17.97835.01NoYes199
36A:A:F238 A:A:L44 24.02218.27NoNo099
37A:A:L44 A:A:L46 23.757811.07NoNo098
38A:A:L282 A:A:N279 38.127813.73YesNo098
39A:A:N279 A:A:W281 38.39524.52NoYes085
40A:A:D378 A:A:H362 33.47746.3NoNo079
41A:A:F290 A:A:H362 21.72424.53YesNo1299
42A:A:F290 A:A:V247 11.48843.93YesNo097
43A:A:I276 A:A:L46 60.11764.28NoNo088
44A:A:D249 A:A:N50 14.90459.42NoNo086
45A:A:D249 A:A:K293 17.86758.3NoNo089
46A:A:K293 A:A:N292 23.80712.8NoYes099
47A:A:N292 A:A:T364 16.7295.85YesNo099
48A:A:H362 A:A:R374 11.287522.57NoYes1294
49A:A:N50 A:A:R265 11.92644.82NoYes1769
50B:B:L117 B:B:W99 14.35527.97YesYes199
51B:B:W332 B:B:Y59 19.10315.79YesNo098
52B:B:M101 B:B:Y59 18.84049.58YesNo098
53B:B:M101 B:B:Y145 19.04624.79YesYes098
54A:A:Q227 B:B:Y145 25.9989.02YesYes198
55B:B:G162 B:B:Y145 39.36275.79NoYes198
56B:B:G162 B:B:S161 44.3913.71NoNo199
57B:B:C114 B:B:L79 10.8526.35NoYes2387
58A:A:Q227 A:A:V224 25.68454.3YesNo199
59A:A:V224 A:A:W234 25.825614.71NoNo099
60A:A:K233 B:B:Y145 53.75363.58YesYes198
61A:A:K233 B:B:D228 68.24346.91YesYes199
62A:A:Q236 A:A:W281 53.29477.67NoYes085
63A:A:K233 A:A:Q236 53.05218.14YesNo098
64A:A:R231 A:A:W234 25.37967NoNo099
65A:A:D272 A:A:R231 24.93699.53NoNo089
66A:A:D272 A:A:F246 24.96613.58NoYes089
67A:A:F246 A:A:I276 59.81636.28YesNo098
68A:A:F246 A:A:V248 11.34293.93YesNo097
69A:A:F246 A:A:F273 38.29593.22YesYes299
70A:A:F246 A:A:L289 34.53063.65YesYes299
71A:A:F345 A:A:V248 10.68799.18YesNo087
72A:A:F273 A:A:F345 10.8077.5YesYes298
73A:A:F345 A:A:L289 10.70598.53YesYes289
74A:A:C359 A:A:F273 23.8014.19YesYes259
75A:A:C359 A:A:L346 44.95613.17YesYes254
76A:A:L346 A:A:R342 43.20643.64YesYes244
77A:A:R342 A:A:Y339 25.85198.23YesYes243
78A:A:K338 A:A:Y339 11.25695.97YesYes253
79A:A:C359 A:A:L289 23.73153.17YesYes259
80A:A:F363 A:A:R342 11.88285.34NoYes254
81A:A:F363 A:A:K338 11.19259.93NoYes255
82A:A:F345 A:A:L270 29.96347.31YesNo086
83A:A:E344 A:A:L270 26.88383.98YesNo056
84A:A:E344 A:A:F312 21.71848.16YesYes1958
85A:A:F312 A:A:I308 15.55893.77YesYes087
86A:A:E330 A:A:V334 14.77284.28YesYes034
87A:A:E330 A:A:K338 16.81254.05YesYes035
88A:A:D331 A:A:V334 12.53111.46YesYes044
89A:A:Y391 R:R:R142 64.270520.58YesYes049
90R:R:H153 R:R:Y152 25.07154.36NoYes058
91B:B:D228 B:B:S227 73.23615.89YesNo196
92B:B:S227 B:B:S245 34.6083.26NoNo169
93B:B:H225 B:B:S245 34.123513.95YesNo199
94B:B:H225 B:B:T243 61.183310.95YesNo198
95B:B:F253 B:B:T243 60.22737.78YesNo168
96B:B:F222 B:B:F253 37.872211.79YesYes186
97B:B:D258 B:B:F222 26.74568.36YesYes178
98B:B:D258 B:B:R22 23.907914.29YesNo076
99B:B:I18 B:B:R22 18.74286.26NoNo076
100B:B:I18 G:G:L19 16.67184.28NoYes079
101B:B:L14 G:G:L19 13.55984.15NoYes089
102B:B:L14 G:G:V16 11.48152.98NoNo087
103B:B:D247 B:B:S227 38.17064.42YesNo196
104B:B:D247 B:B:H225 34.15093.78YesYes199
105B:B:C271 B:B:D290 29.72736.22NoNo056
106B:B:C271 B:B:D291 28.55466.22NoNo058
107B:B:D291 B:B:Y289 20.20523.45NoYes087
108B:B:W297 B:B:Y289 16.645910.61NoYes087
109B:B:W297 B:B:Y264 16.22086.75NoYes085
110B:B:L285 B:B:Y264 13.69044.69YesYes065
111B:B:F278 B:B:L285 11.96288.53NoYes076
112B:B:F235 B:B:F278 11.09468.57YesNo067
113B:B:R68 B:B:Y85 31.645417.49NoNo054
114B:B:Y85 G:G:F61 32.69136.19NoYes048
115B:B:G319 B:B:M61 14.10293.49NoYes056
116B:B:G319 B:B:S277 13.65413.71NoNo055
117B:B:S277 B:B:V320 11.94123.23NoNo057
118B:B:V320 B:B:V327 11.49273.21NoYes076
119B:B:V327 B:B:W339 14.91033.68YesYes069
120G:G:F61 G:G:N59 13.66093.62YesYes589
121B:B:S84 G:G:F61 50.11185.28NoYes058
122B:B:S84 B:B:W63 51.08724.94NoYes057
123B:B:C317 B:B:M61 66.80986.48NoYes076
124B:B:H142 B:B:S161 41.836215.34YesNo199
125B:B:H142 B:B:T159 18.45885.48YesYes199
126B:B:C121 B:B:T159 18.16513.38YesYes189
127B:B:C121 B:B:C149 18.33473.64YesNo088
128B:B:C149 B:B:T102 17.83798.45NoNo088
129B:B:C148 B:B:T102 15.81043.38NoNo368
130B:B:H142 B:B:W169 23.1927.41YesYes198
131B:B:I157 B:B:W169 21.62124.7NoYes078
132B:B:I157 B:B:I171 21.13354.42NoNo076
133B:B:I123 B:B:I171 15.22484.42NoNo066
134B:B:C148 B:B:L190 15.34363.17NoYes365
135B:B:F241 B:B:F253 20.465511.79YesYes166
136B:B:F241 B:B:V200 17.495319.66YesYes166
137B:B:F222 B:B:Q220 10.24169.37YesYes187
138B:B:L198 B:B:L210 10.32792.77NoYes035
139R:R:P72 R:R:Y152 23.49254.17YesYes778
140R:R:P72 R:R:S71 15.47533.56YesNo077
141R:R:S71 R:R:Y74 14.85195.09NoYes078
142G:G:N59 G:G:V54 11.87314.43YesYes596
143R:R:R142 R:R:Y298 61.29276.17YesYes899
144R:R:D294 R:R:Y298 59.15733.45NoYes899
145R:R:D294 R:R:N290 58.85816.73NoNo099
146R:R:N290 R:R:W254 58.149118.08NoYes097
147R:R:M128 R:R:W254 39.06363.49NoYes057
148R:R:F257 R:R:M128 38.26133.73NoNo055
149R:R:F257 R:R:L261 29.172610.96NoNo055
150R:R:L189 R:R:L261 20.82434.15YesNo045
151R:R:F179 R:R:L189 19.11393.65YesYes054
152R:R:C125 R:R:F179 13.41088.38NoYes2845
153R:R:C125 R:R:S176 13.03686.89NoNo047
154R:R:S126 R:R:S176 12.59733.26NoNo057
155R:R:I123 R:R:S126 12.15713.1YesNo045
156R:R:S131 R:R:W254 16.1344.94NoYes097
157R:R:D84 R:R:S131 15.70614.42YesNo099
158R:R:D84 R:R:L80 11.0059.5YesNo099
159R:R:F134 R:R:L80 10.55474.87YesNo089
160R:R:F147 R:R:I146 10.71415.02YesYes068
161R:R:F147 R:R:R213 10.08393.21YesYes466
162R:R:F277 R:R:H260 11.571124.89YesYes034
163A:A:I235 A:A:L282 36.96342.85NoYes099
164B:B:M61 B:B:W63 53.5884.65YesYes067
165B:B:C317 B:B:S316 67.19673.44NoNo079
166B:B:L117 B:B:Y145 12.74993.52YesYes198
167A:A:I235 A:A:L46 36.8052.85NoNo098
168A:A:W281 B:B:D290 24.133210.05YesNo156
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K3P
Class A
SubFamily Peptide
Type Melanocortin
SubType MC1
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 2.98
Date 2025-08-06
D.O.I. doi.org/10.1016/j.str.2025.03.004
Net Summary
Imin 3.07
Number of Linked Nodes 816
Number of Links 962
Number of Hubs 148
Number of Links mediated by Hubs 549
Number of Communities 30
Number of Nodes involved in Communities 212
Number of Links involved in Communities 286
Path Summary
Number Of Nodes in MetaPath 169
Number Of Links MetaPath 168
Number of Shortest Paths 781859
Length Of Smallest Path 3
Average Path Length 24.2213
Length of Longest Path 57
Minimum Path Strength 1.185
Average Path Strength 6.87318
Maximum Path Strength 22.06
Minimum Path Correlation 0.7
Average Path Correlation 0.976275
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 3.57143
Average % Of Corr. Nodes 50.3998
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.4189
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• multicellular organismal process   • regulation of tumor necrosis factor production   • regulation of cellular process   • negative regulation of biological process   • negative regulation of tumor necrosis factor production   • cytokine production   • regulation of cytokine production   • negative regulation of cellular process   • regulation of multicellular organismal process   • negative regulation of macromolecule metabolic process   • regulation of biosynthetic process   • regulation of biological process   • negative regulation of metabolic process   • biological regulation   • tumor necrosis factor superfamily cytokine production   • negative regulation of cytokine production   • regulation of macromolecule metabolic process   • gene expression   • macromolecule biosynthetic process   • tumor necrosis factor production   • regulation of gene expression   • negative regulation of gene expression   • regulation of tumor necrosis factor superfamily cytokine production   • biosynthetic process   • negative regulation of biosynthetic process   • negative regulation of macromolecule biosynthetic process   • negative regulation of tumor necrosis factor superfamily cytokine production   • metabolic process   • cellular process   • regulation of macromolecule biosynthetic process   • macromolecule metabolic process   • negative regulation of multicellular organismal process   • regulation of metabolic process   • pigment metabolic process   • pigment biosynthetic process   • melanin metabolic process   • secondary metabolic process   • secondary metabolite biosynthetic process   • phenol-containing compound metabolic process   • phenol-containing compound biosynthetic process   • melanin biosynthetic process   • response to light stimulus   • response to stimulus   • response to radiation   • response to abiotic stimulus   • response to UV   • UV protection   • cellular response to stimulus   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • phospholipase C-activating G protein-coupled receptor signaling pathway   • pigmentation   • positive regulation of feeding behavior   • positive regulation of biological process   • feeding behavior   • regulation of behavior   • behavior   • positive regulation of behavior   • positive regulation of multicellular organismal process   • regulation of feeding behavior   • cellular response to environmental stimulus   • nucleobase-containing compound metabolic process   • cellular response to stress   • response to stress   • cellular response to light stimulus   • DNA repair   • primary metabolic process   • DNA metabolic process   • cellular response to radiation   • nucleic acid metabolic process   • UV-damage excision repair   • DNA damage response   • cellular response to abiotic stimulus   • cellular response to UV   • system process   • sensory perception   • nervous system process   • sensory perception of pain   • intracellular signal transduction   • positive regulation of cell communication   • positive regulation of signal transduction   • regulation of signal transduction   • positive regulation of cAMP/PKA signal transduction   • positive regulation of response to stimulus   • cAMP/PKA signal transduction   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of cellular process   • regulation of signaling   • positive regulation of intracellular signal transduction   • regulation of cAMP/PKA signal transduction   • regulation of response to stimulus   • regulation of cell communication   • positive regulation of signaling   • positive regulation of DNA-templated transcription   • RNA metabolic process   • positive regulation of macromolecule biosynthetic process   • regulation of primary metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • positive regulation of metabolic process   • DNA-templated transcription   • regulation of RNA metabolic process   • transcription by RNA polymerase II   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of transcription by RNA polymerase II   • positive regulation of transcription by RNA polymerase II   • nucleobase-containing compound biosynthetic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • regulation of DNA-templated transcription   • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • intracellular anatomical structure   • cytoplasm   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of chemical stimulus   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • D2 dopamine receptor binding   • adenylate cyclase inhibitor activity   • molecular function inhibitor activity   • cyclase inhibitor activity   • enzyme inhibitor activity   • magnesium ion binding   • GDP binding   • G protein-coupled serotonin receptor binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • adenylate cyclase-inhibiting serotonin receptor signaling pathway   • G protein-coupled serotonin receptor signaling pathway   • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway   • cell division   • leukocyte migration   • mononuclear cell migration   • lymphocyte migration   • cell migration   • T cell migration   • cell motility   • regulation of steroid biosynthetic process   • regulation of cholesterol biosynthetic process   • regulation of cholesterol metabolic process   • steroid metabolic process   • regulation of lipid metabolic process   • sterol metabolic process   • cholesterol metabolic process   • lipid biosynthetic process   • alcohol metabolic process   • regulation of small molecule metabolic process   • positive regulation of lipid metabolic process   • small molecule metabolic process   • steroid biosynthetic process   • secondary alcohol biosynthetic process   • regulation of alcohol biosynthetic process   • small molecule biosynthetic process   • regulation of steroid metabolic process   • cholesterol biosynthetic process   • positive regulation of cholesterol biosynthetic process   • secondary alcohol metabolic process   • positive regulation of steroid biosynthetic process   • sterol biosynthetic process   • positive regulation of lipid biosynthetic process   • regulation of sterol biosynthetic process   • alcohol biosynthetic process   • positive regulation of cholesterol metabolic process   • positive regulation of steroid metabolic process   • regulation of lipid biosynthetic process   • positive regulation of small molecule metabolic process   • positive regulation of alcohol biosynthetic process   • positive regulation of sterol biosynthetic process   • lipid metabolic process   • negative regulation of protein transport   • negative regulation of transport   • negative regulation of secretion   • negative regulation of hormone secretion   • negative regulation of secretion by cell   • negative regulation of peptide hormone secretion   • negative regulation of establishment of protein localization   • negative regulation of protein secretion   • negative regulation of signaling   • negative regulation of cell communication   • negative regulation of peptide secretion   • negative regulation of protein localization   • negative regulation of insulin secretion   • regulation of cytoskeleton organization   • regulation of cellular component organization   • microtubule cytoskeleton organization   • regulation of mitotic spindle organization   • mitotic cell cycle   • cellular component organization   • cell cycle   • cellular component organization or biogenesis   • regulation of cell cycle   • microtubule cytoskeleton organization involved in mitosis   • spindle organization   • cell cycle process   • regulation of cell cycle process   • regulation of microtubule-based process   • regulation of spindle organization   • regulation of organelle organization   • mitotic spindle organization   • organelle organization   • mitotic cell cycle process   • microtubule-based process   • cytoskeleton organization   • regulation of microtubule cytoskeleton organization   • positive regulation of protein localization to cell periphery   • protein localization to cell periphery   • positive regulation of protein localization to cell cortex   • regulation of protein localization to cell periphery   • regulation of protein localization to cell cortex   • positive regulation of protein localization   • protein localization to cell cortex   • cellular response to forskolin   • response to forskolin   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network   • midbody   • nucleus   • membrane-enclosed lumen   • intracellular membraneless organelle   • nucleolus   • intracellular organelle lumen   • organelle lumen   • membraneless organelle   • nuclear lumen   • cell cortex   • centrosome   • microtubule organizing center   • cytoskeleton   • microtubule cytoskeleton   • centriolar satellite   • nucleoplasm   • ciliary basal body
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K3P_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRITSGIF 
ETKFQVDKV NFHMFDVGQ RDERRKWIQ CFNDVTAII FVVSSYNRL 
QEALNFKSI WNNRWLRTI SVILFLNKQ DLLAEKVLA GKSKIEDYF 
PEFARYTTP EDATPEPGE DPRVTRAKY FIRDEFLRI STASGDGRH 
YCYPHFTCV DTENRRFND CRDIIQRMH LRQYELLLS ADAVRSMDN 
YADDDSAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K3P_Chain_B
LDQLRQEAE QLKNQIRDA RKACADIDP VGRIQMRTR RTLRGHLAK 
IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI PLRSSWVMT 
CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE LAGHTGYLS 
CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH TGDVMSLSL 
APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD INAICFFPN 
GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI TSVSFSKSG 
RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL GVTDDGMAV 
ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>9K3P_Chain_G
AQARKLVEQ LKMEANIDR IKVSKAAAD LMAYCEAHA KEDPLLTPV 
PASENPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ01726
Sequence
>9K3P_Chain_R
SDGLFLSLG LVSLVENAL VVATIAKNR NLHSPMYCF ICCLALSDL 
LVSGSNVLE TAVILLLEA GALVARAAV LQQLDNVID VITCSSMLS 
SLCFLGAIA VDRYISIFY ALRYHSIVT LPRARRAVA AIWVASVVF 
STLFIAYYD HVAVLLCLV VFFLAMLVL MAVLYVHML ARACQHAQG 
IARLHLKGA VTLTILLGI FFLCWGPFF LHLTLIVLC PEHPTCGCI 
FKNFNLFLA LIICNAIID PLIYAFHSQ ELRRT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7F4DAPeptideMelanocortinMC1Homo sapiensα-MSH-chim(NtGi1-Gs)/β1/γ232021-09-08doi.org/10.1038/s41422-021-00557-y
7F4D (No Gprot) APeptideMelanocortinMC1Homo sapiensα-MSH-32021-09-08doi.org/10.1038/s41422-021-00557-y
7F4FAPeptideMelanocortinMC1Homo sapiensAfamelanotide-chim(NtGi1-Gs)/β1/γ22.92021-09-08doi.org/10.1038/s41422-021-00557-y
7F4F (No Gprot) APeptideMelanocortinMC1Homo sapiensAfamelanotide-2.92021-09-08doi.org/10.1038/s41422-021-00557-y
7F4HAPeptideMelanocortinMC1Homo sapiensAfamelanotide-chim(NtGi1-Gs)/β1/γ22.72021-09-08doi.org/10.1038/s41422-021-00557-y
7F4H (No Gprot) APeptideMelanocortinMC1Homo sapiensAfamelanotide-2.72021-09-08doi.org/10.1038/s41422-021-00557-y
7F4IAPeptideMelanocortinMC1Homo sapiensSHU9119-chim(NtGi1-Gs)/β1/γ23.12021-09-08doi.org/10.1038/s41422-021-00557-y
7F4I (No Gprot) APeptideMelanocortinMC1Homo sapiensSHU9119-3.12021-09-08doi.org/10.1038/s41422-021-00557-y
9K3P (No Gprot) APeptideMelanocortinMC1Homo sapiens--2.982025-08-06doi.org/10.1016/j.str.2025.03.004




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