psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	L:L:S3	4.22	No	No	0	0	0
2	L:L:?4	L:L:E5	4.97	No	No	0	0	0
3	L:L:?4	R:R:D117	8.91	No	No	0	0	6
4	L:L:E5	L:L:K11	13.5	No	No	0	0	0
5	L:L:H6	R:R:D42	7.56	Yes	Yes	3	0	3
6	L:L:H6	R:R:F45	6.79	Yes	Yes	3	0	6
7	L:L:H6	R:R:T95	8.21	Yes	Yes	3	0	5
8	L:L:H6	R:R:I98	5.3	Yes	No	3	0	3
9	L:L:?7	L:L:R8	12.35	Yes	Yes	1	0	0
10	L:L:?7	L:L:W9	6.76	Yes	Yes	1	0	0
11	L:L:?7	R:R:E94	7.86	Yes	No	1	0	4
12	L:L:?7	R:R:D121	14.95	Yes	Yes	1	0	5
13	L:L:?7	R:R:T124	11.24	Yes	No	0	0	5
14	L:L:?7	R:R:C125	6.72	Yes	No	0	0	4
15	L:L:?7	R:R:M128	8.39	Yes	Yes	1	0	5
16	L:L:?7	R:R:F257	6.19	Yes	Yes	0	0	5
17	L:L:?7	R:R:L284	4.69	Yes	No	0	0	4
18	L:L:R8	L:L:W9	6	Yes	Yes	1	0	0
19	L:L:R8	R:R:D117	7.15	Yes	No	1	0	6
20	L:L:R8	R:R:N118	8.44	Yes	Yes	1	0	4
21	L:L:R8	R:R:D121	14.29	Yes	Yes	1	0	5
22	L:L:R8	R:R:I180	8.77	Yes	Yes	1	0	5
23	L:L:R8	R:R:Y183	11.32	Yes	No	1	0	3
24	L:L:W9	R:R:Y183	5.79	Yes	No	1	0	3
25	L:L:W9	R:R:L189	13.67	Yes	No	1	0	4
26	L:L:W9	R:R:L192	4.56	Yes	No	1	0	5
27	L:L:W9	R:R:L261	4.56	Yes	Yes	1	0	5
28	L:L:G10	R:R:F280	10.54	No	Yes	0	0	4
29	L:L:P12	R:R:F277	8.67	No	Yes	0	0	3
30	R:R:E37	R:R:S39	10.06	No	No	0	2	2
31	R:R:E37	R:R:K278	9.45	No	No	0	2	2
32	R:R:L282	R:R:V38	8.94	Yes	No	0	3	5
33	R:R:I40	R:R:L44	8.56	Yes	No	0	6	5
34	R:R:F45	R:R:I40	5.02	Yes	Yes	3	6	6
35	R:R:I40	R:R:N281	4.25	Yes	No	3	6	4
36	R:R:D42	R:R:T95	4.34	Yes	Yes	3	3	5
37	R:R:D42	R:R:I98	4.2	Yes	No	3	3	3
38	R:R:D42	R:R:L99	9.5	Yes	No	0	3	4
39	R:R:L44	R:R:L48	5.54	No	No	0	5	6
40	R:R:F45	R:R:T95	5.19	Yes	Yes	3	6	5
41	R:R:F45	R:R:N281	7.25	Yes	No	3	6	4
42	R:R:L46	R:R:T95	5.9	No	Yes	0	5	5
43	R:R:S52	R:R:S88	6.52	Yes	No	5	8	9
44	R:R:I292	R:R:S52	6.19	No	Yes	0	5	8
45	R:R:E55	R:R:I292	4.1	Yes	No	0	8	5
46	R:R:E55	R:R:P295	7.86	Yes	No	0	8	9
47	R:R:E55	R:R:F300	4.66	Yes	Yes	0	8	5
48	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
49	R:R:D84	R:R:N56	6.73	Yes	Yes	0	9	9
50	R:R:L85	R:R:N56	4.12	No	Yes	0	7	9
51	R:R:N56	R:R:P295	6.52	Yes	No	0	9	9
52	R:R:F300	R:R:V59	3.93	Yes	No	0	5	9
53	R:R:C78	R:R:V60	5.12	No	No	0	6	7
54	R:R:L82	R:R:V60	4.47	No	No	0	6	7
55	R:R:L305	R:R:T62	5.9	No	No	0	8	8
56	R:R:T308	R:R:T62	4.71	Yes	No	0	8	8
57	R:R:L309	R:R:T62	5.9	Yes	No	0	6	8
58	R:R:I63	R:R:L69	5.71	No	Yes	0	8	8
59	R:R:C78	R:R:I63	8.18	No	No	0	6	8
60	R:R:N66	R:R:N68	9.54	Yes	No	7	8	7
61	R:R:L69	R:R:N66	9.61	Yes	Yes	0	8	8
62	R:R:E304	R:R:N66	13.15	No	Yes	7	7	8
63	R:R:N66	R:R:T308	13.16	Yes	Yes	0	8	8
64	R:R:H70	R:R:R67	7.9	No	No	0	8	7
65	R:R:E304	R:R:N68	9.2	No	No	7	7	7
66	R:R:L69	R:R:Y74	10.55	Yes	Yes	0	8	8
67	R:R:L305	R:R:L69	4.15	No	Yes	0	8	8
68	R:R:P72	R:R:S71	5.34	Yes	No	0	7	7
69	R:R:L158	R:R:P72	6.57	No	Yes	0	3	7
70	R:R:M73	R:R:Y74	8.38	No	Yes	0	8	8
71	R:R:D141	R:R:M73	5.54	Yes	No	0	9	8
72	R:R:S302	R:R:Y74	7.63	No	Yes	0	8	8
73	R:R:C75	R:R:R162	5.57	No	No	0	4	1
74	R:R:A137	R:R:F76	5.55	No	No	0	7	7
75	R:R:D141	R:R:F76	5.97	Yes	No	0	9	7
76	R:R:C79	R:R:F134	9.78	No	Yes	4	9	8
77	R:R:C79	R:R:V165	8.54	No	No	4	9	7
78	R:R:D84	R:R:L80	9.5	Yes	Yes	1	9	9
79	R:R:L80	R:R:S131	4.5	Yes	No	1	9	9
80	R:R:L135	R:R:L80	5.54	Yes	Yes	1	8	9
81	R:R:I138	R:R:L80	4.28	No	Yes	1	9	9
82	R:R:S130	R:R:S83	4.89	No	No	4	7	8
83	R:R:F134	R:R:S83	6.61	Yes	No	4	8	8
84	R:R:S83	R:R:W169	7.41	No	Yes	4	8	9
85	R:R:D84	R:R:S131	5.89	Yes	No	1	9	9
86	R:R:D294	R:R:D84	6.65	Yes	Yes	1	9	9
87	R:R:S127	R:R:V87	6.46	No	No	0	7	8
88	R:R:I123	R:R:S90	6.19	No	No	0	4	5
89	R:R:S90	R:R:T124	4.8	No	No	0	5	5
90	R:R:I288	R:R:N91	7.08	No	No	0	6	7
91	R:R:I120	R:R:L93	5.71	No	No	0	5	8
92	R:R:E94	R:R:I120	5.47	No	No	0	4	5
93	R:R:D121	R:R:E94	6.5	Yes	No	1	5	4
94	R:R:L116	R:R:V97	4.47	No	No	0	3	4
95	R:R:L101	R:R:L106	5.54	No	No	0	3	3
96	R:R:L101	R:R:L113	8.3	No	No	0	3	6
97	R:R:A108	R:R:L113	4.73	No	No	0	1	6
98	R:R:N118	R:R:Q115	6.6	Yes	No	0	4	1
99	R:R:I120	R:R:L116	7.14	No	No	0	5	3
100	R:R:D117	R:R:D121	10.65	No	Yes	1	6	5
101	R:R:I180	R:R:N118	4.25	Yes	Yes	1	5	4
102	R:R:D121	R:R:I180	4.2	Yes	Yes	1	5	5
103	R:R:I180	R:R:V122	4.61	Yes	No	0	5	5
104	R:R:S126	R:R:S176	4.89	No	No	0	5	7
105	R:R:M128	R:R:W254	5.82	Yes	Yes	1	5	7
106	R:R:I287	R:R:M128	4.37	No	Yes	1	7	5
107	R:R:L129	R:R:S172	4.5	No	No	0	5	7
108	R:R:S130	R:R:W169	16.06	No	Yes	4	7	9
109	R:R:S130	R:R:S172	4.89	No	No	0	7	7
110	R:R:S131	R:R:W254	4.94	No	Yes	1	9	7
111	R:R:F195	R:R:L132	8.53	No	Yes	1	4	7
112	R:R:L132	R:R:M199	5.65	Yes	No	1	7	7
113	R:R:C133	R:R:I168	6.55	No	No	0	4	6
114	R:R:C133	R:R:F195	5.59	No	No	0	4	4
115	R:R:F134	R:R:V165	7.87	Yes	No	4	8	7
116	R:R:F134	R:R:I168	12.56	Yes	No	0	8	6
117	R:R:F134	R:R:W169	7.02	Yes	Yes	4	8	9
118	R:R:F250	R:R:L135	7.31	Yes	Yes	1	8	8
119	R:R:D294	R:R:L135	4.07	Yes	Yes	1	9	8
120	R:R:L135	R:R:Y298	4.69	Yes	Yes	1	8	9
121	R:R:I138	R:R:R142	5.01	No	No	1	9	9
122	R:R:I138	R:R:Y298	7.25	No	Yes	1	9	9
123	R:R:A139	R:R:Y207	5.34	No	Yes	0	9	8
124	R:R:D141	R:R:Y152	10.34	Yes	Yes	8	9	8
125	R:R:D141	R:R:V156	4.38	Yes	Yes	8	9	7
126	R:R:R142	R:R:Y207	8.23	No	Yes	0	9	8
127	R:R:R142	R:R:Y298	7.2	No	Yes	1	9	9
128	R:R:F147	R:R:Y143	15.47	Yes	No	9	6	7
129	R:R:L206	R:R:Y143	10.55	No	No	0	5	7
130	R:R:H209	R:R:Y143	7.62	No	No	9	6	7
131	R:R:I144	R:R:I155	5.89	No	No	0	6	5
132	R:R:I144	R:R:V156	4.61	No	Yes	0	6	7
133	R:R:S145	R:R:Y152	8.9	No	Yes	0	9	8
134	R:R:F147	R:R:I146	11.3	Yes	No	0	6	8
135	R:R:F147	R:R:H209	24.89	Yes	No	9	6	6
136	R:R:F147	R:R:R213	4.28	Yes	No	0	6	6
137	R:R:H153	R:R:Y152	8.71	No	Yes	0	5	8
138	R:R:V156	R:R:Y152	6.31	Yes	Yes	8	7	8
139	R:R:P159	R:R:T157	8.74	No	No	0	4	8
140	R:R:F179	R:R:V188	9.18	Yes	No	0	5	4
141	R:R:F179	R:R:L192	6.09	Yes	No	0	5	5
142	R:R:A181	R:R:Y182	4	No	No	0	3	4
143	R:R:D184	R:R:H185	11.35	No	No	0	4	4
144	R:R:V186	R:R:V265	4.81	No	Yes	0	1	4
145	R:R:L189	R:R:L261	5.54	No	Yes	1	4	5
146	R:R:L189	R:R:V265	4.47	No	Yes	0	4	4
147	R:R:L190	R:R:V265	8.94	No	Yes	0	4	4
148	R:R:L192	R:R:L261	4.15	No	Yes	1	5	5
149	R:R:T262	R:R:V193	4.76	No	No	0	4	4
150	R:R:F195	R:R:M199	8.71	No	No	1	4	7
151	R:R:F196	R:R:F250	6.43	Yes	Yes	1	7	8
152	R:R:F196	R:R:W254	4.01	Yes	Yes	1	7	7
153	R:R:F196	R:R:G255	4.52	Yes	No	0	7	5
154	R:R:F196	R:R:F258	27.86	Yes	No	0	7	5
155	R:R:L202	R:R:L206	6.92	No	No	0	5	5
156	R:R:M203	R:R:Y207	7.18	No	Yes	0	8	8
157	R:R:F250	R:R:M203	7.46	Yes	No	0	8	8
158	R:R:M210	R:R:Y207	4.79	No	Yes	0	9	8
159	R:R:L243	R:R:Y207	5.86	No	Yes	0	8	8
160	R:R:L246	R:R:Y207	7.03	No	Yes	0	8	8
161	R:R:L247	R:R:Y207	4.69	No	Yes	0	7	8
162	R:R:L211	R:R:L243	6.92	No	No	0	6	8
163	R:R:Q216	R:R:R213	11.68	No	No	0	4	6
164	R:R:H217	R:R:R213	15.8	No	No	0	8	6
165	R:R:L246	R:R:Y298	5.86	No	Yes	0	8	9
166	R:R:I249	R:R:I293	7.36	No	No	0	6	5
167	R:R:I249	R:R:I297	4.42	No	No	0	6	8
168	R:R:F250	R:R:W254	4.01	Yes	Yes	1	8	7
169	R:R:C253	R:R:N290	9.45	No	No	0	8	9
170	R:R:I287	R:R:W254	11.74	No	Yes	1	7	7
171	R:R:N290	R:R:W254	19.21	No	Yes	0	9	7
172	R:R:G255	R:R:P256	4.06	No	No	0	5	9
173	R:R:F283	R:R:P256	8.67	Yes	No	0	5	9
174	R:R:F257	R:R:F258	9.65	Yes	No	0	5	5
175	R:R:F257	R:R:L261	8.53	Yes	Yes	0	5	5
176	R:R:F257	R:R:F280	4.29	Yes	Yes	0	5	4
177	R:R:F257	R:R:I287	5.02	Yes	No	0	5	7
178	R:R:L259	R:R:T262	4.42	No	No	0	6	4
179	R:R:L259	R:R:L263	4.15	No	No	0	6	4
180	R:R:H260	R:R:I264	9.28	Yes	No	2	4	4
181	R:R:F277	R:R:H260	9.05	Yes	Yes	2	3	4
182	R:R:F280	R:R:H260	16.97	Yes	Yes	0	4	4
183	R:R:F283	R:R:H260	6.79	Yes	Yes	2	5	4
184	R:R:C273	R:R:L263	9.52	Yes	No	0	4	4
185	R:R:I276	R:R:L263	5.71	No	No	0	4	4
186	R:R:F277	R:R:I264	11.3	Yes	No	2	3	4
187	R:R:C267	R:R:C273	7.28	No	Yes	2	3	4
188	R:R:H270	R:R:P271	15.25	Yes	No	0	4	3
189	R:R:H270	R:R:T272	12.32	Yes	No	0	4	4
190	R:R:C273	R:R:F277	4.19	Yes	Yes	2	4	3
191	R:R:F277	R:R:G274	6.02	Yes	No	0	3	2
192	R:R:L282	R:R:N279	4.12	Yes	No	2	3	4
193	R:R:F283	R:R:N279	4.83	Yes	No	2	5	4
194	R:R:F280	R:R:L284	10.96	Yes	No	0	4	4
195	R:R:F283	R:R:L282	6.09	Yes	Yes	2	5	3
196	R:R:L282	R:R:L286	4.15	Yes	No	0	3	7
197	R:R:D294	R:R:N290	8.08	Yes	No	0	9	9
198	R:R:D294	R:R:Y298	4.6	Yes	Yes	1	9	9
199	R:R:I297	R:R:Y298	10.88	No	Yes	0	8	9
200	R:R:F300	R:R:L305	6.09	Yes	No	0	5	8
201	R:R:F300	R:R:L309	8.53	Yes	Yes	0	5	6
202	R:R:Q303	R:R:R306	10.51	No	No	0	6	9
203	R:R:E304	R:R:R307	11.63	No	No	0	7	6
204	R:R:E311	R:R:R307	4.65	No	No	0	4	6
205	R:R:E311	R:R:T308	8.47	No	Yes	0	4	8
206	R:R:L309	R:R:L313	6.92	Yes	No	6	6	6
207	R:R:R109	R:R:V112	3.92	No	No	0	3	3
208	R:R:R160	R:R:T157	3.88	No	No	0	7	8
209	R:R:A161	R:R:P72	3.74	No	Yes	0	6	7
210	R:R:G89	R:R:V92	3.68	No	No	0	3	6
211	R:R:F179	R:R:L129	3.65	Yes	No	0	5	5
212	R:R:F196	R:R:L132	3.65	Yes	Yes	1	7	7
213	R:R:F250	R:R:L132	3.65	Yes	Yes	1	8	7
214	R:R:F251	R:R:L200	3.65	No	No	0	6	5
215	R:R:I77	R:R:Y74	3.63	No	Yes	0	7	8
216	R:R:I155	R:R:Y148	3.63	No	No	0	5	6
217	R:R:P72	R:R:V156	3.53	Yes	Yes	0	7	7
218	R:R:L178	R:R:Y182	3.52	No	No	0	5	4
219	R:R:C125	R:R:S176	3.44	No	No	0	4	7
220	R:R:A291	R:R:S52	3.42	No	Yes	0	9	8
221	R:R:L86	R:R:W169	3.42	No	Yes	0	7	9
222	R:R:G248	R:R:L252	3.42	No	No	0	6	4
223	R:R:A299	R:R:V59	3.39	No	No	0	8	9
224	R:R:H185	R:R:Y182	3.27	No	No	0	4	4
225	R:R:A285	R:R:I40	3.25	No	Yes	0	5	6
226	R:R:F196	R:R:F251	3.22	Yes	No	0	7	6
227	R:R:T177	R:R:V122	3.17	No	No	0	4	5
228	R:R:C289	R:R:L286	3.17	No	No	0	4	7
229	R:R:I288	R:R:S88	3.1	No	No	0	6	9
230	R:R:I146	R:R:S145	3.1	No	No	0	8	9
231	R:R:I40	R:R:V38	3.07	Yes	No	0	6	5
232	R:R:I292	R:R:V51	3.07	No	No	0	5	5
233	R:R:I144	R:R:V140	3.07	No	No	0	6	6
234	R:R:K65	R:R:V312	3.04	No	No	0	5	7
235	R:R:M128	R:R:V87	3.04	Yes	No	0	5	8
236	R:R:K65	R:R:T308	3	No	Yes	0	5	8
237	R:R:G220	R:R:R223	3	No	No	0	5	3
238	R:R:L46	R:R:V92	2.98	No	No	0	5	6
239	R:R:L50	R:R:V92	2.98	No	No	0	5	6
240	R:R:L101	R:R:V97	2.98	No	No	0	3	4
241	R:R:L246	R:R:T242	2.95	No	No	0	8	9
242	R:R:C267	R:R:H270	2.95	No	Yes	2	3	4
243	R:R:C273	R:R:H270	2.95	Yes	Yes	2	4	4
244	R:R:I245	R:R:I297	2.94	No	No	0	7	8
245	R:R:C191	R:R:F179	2.79	No	Yes	0	4	5
246	R:R:L53	R:R:L85	2.77	No	No	0	5	7
247	R:R:L309	R:R:L58	2.77	Yes	No	6	6	7
248	R:R:L313	R:R:L58	2.77	No	No	6	6	7
249	R:R:A164	R:R:F76	2.77	No	No	0	6	7
250	R:R:A171	R:R:F175	2.77	No	No	0	3	4
251	R:R:E55	R:R:L296	2.65	Yes	No	0	8	5
252	R:R:I155	R:R:R151	2.51	No	No	0	5	6
253	R:R:F196	R:R:L197	2.44	Yes	No	0	7	4
254	R:R:F175	R:R:F179	2.14	No	Yes	0	4	5
255	L:L:P12	R:R:P268	1.95	No	No	0	0	3
256	R:R:A139	R:R:G136	1.95	No	No	0	9	7
257	R:R:G43	R:R:S41	1.86	No	No	0	5	5
258	R:R:G49	R:R:S52	1.86	No	Yes	5	6	8
259	R:R:G49	R:R:S88	1.86	No	No	5	6	9
260	R:R:C75	R:R:C79	1.82	No	No	0	4	9
261	R:R:G239	R:R:T242	1.82	No	No	0	8	9
262	R:R:A103	R:R:A105	1.79	No	No	0	5	4
263	R:R:G43	R:R:L46	1.71	No	No	0	5	5
264	R:R:A108	R:R:V112	1.7	No	No	0	1	3
265	R:R:L158	R:R:P159	1.64	No	No	0	3	4
266	R:R:G220	R:R:Q219	1.64	No	No	0	5	4
267	R:R:S126	R:R:V173	1.62	No	No	0	5	3
268	R:R:A57	R:R:L85	1.58	No	No	0	5	7
269	R:R:A105	R:R:L100	1.58	No	No	0	4	4
270	R:R:A214	R:R:L211	1.58	No	No	0	8	6
271	R:R:I123	R:R:V119	1.54	No	No	0	4	4
272	R:R:K238	R:R:T242	1.5	No	No	0	8	9
273	R:R:L53	R:R:V54	1.49	No	No	0	5	4
274	R:R:L58	R:R:V54	1.49	No	No	0	7	4
275	R:R:L178	R:R:V174	1.49	No	No	0	5	4
276	R:R:L266	R:R:V265	1.49	No	Yes	0	3	4
277	R:R:L178	R:R:T177	1.47	No	No	0	5	4
278	R:R:P159	R:R:R163	1.44	No	No	0	4	3
279	R:R:L100	R:R:L106	1.38	No	No	0	4	3
280	L:L:Y2	R:R:A110	1.33	No	No	0	0	3
281	R:R:H217	R:R:I221	1.33	No	No	0	8	7
282	R:R:N118	R:R:Q114	1.32	Yes	No	0	4	2
283	L:L:S3	L:L:Y2	1.27	No	No	0	0	0
284	R:R:F251	R:R:L252	1.22	No	No	0	6	4
285	R:R:F300	R:R:R306	1.07	Yes	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:H6	6.965	4	3	0
2	L:L:?7	8.79445	9	1	0
3	L:L:R8	9.76	7	1	0
4	L:L:W9	6.89	6	1	0
5	R:R:I40	4.83	5	3	6
6	R:R:D42	6.4	4	3	3
7	R:R:F45	6.0625	4	3	6
8	R:R:S52	4.4975	4	5	8
9	R:R:E55	4.8175	4	0	8
10	R:R:N56	5.515	4	0	9
11	R:R:N66	11.365	4	7	8
12	R:R:L69	7.505	4	0	8
13	R:R:P72	4.795	4	0	7
14	R:R:Y74	7.5475	4	0	8
15	R:R:L80	5.955	4	1	9
16	R:R:D84	7.1925	4	1	9
17	R:R:T95	5.91	4	3	5
18	R:R:N118	5.1525	4	1	4
19	R:R:D121	10.118	5	1	5
20	R:R:M128	5.405	4	1	5
21	R:R:L132	5.37	4	1	7
22	R:R:F134	8.768	5	4	8
23	R:R:L135	5.4025	4	1	8
24	R:R:D141	6.5575	4	8	9
25	R:R:F147	13.985	4	9	6
26	R:R:Y152	8.565	4	8	8
27	R:R:V156	4.7075	4	8	7
28	R:R:W169	8.4775	4	4	9
29	R:R:F179	4.77	5	0	5
30	R:R:I180	5.4575	4	1	5
31	R:R:F196	7.44714	7	1	7
32	R:R:Y207	6.16	7	0	8
33	R:R:F250	5.772	5	1	8
34	R:R:W254	8.28833	6	1	7
35	R:R:F257	6.736	5	0	5
36	R:R:H260	10.5225	4	2	4
37	R:R:L261	5.695	4	1	5
38	R:R:V265	4.9275	4	0	4
39	R:R:H270	8.3675	4	2	4
40	R:R:C273	5.985	4	2	4
41	R:R:F277	7.846	5	2	3
42	R:R:F280	10.69	4	0	4
43	R:R:L282	5.825	4	2	3
44	R:R:F283	6.595	4	2	5
45	R:R:D294	5.85	4	1	9
46	R:R:Y298	6.74667	6	1	9
47	R:R:F300	4.856	5	0	5
48	R:R:T308	7.335	4	0	8
49	R:R:L309	6.03	4	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	R:R:D117	16.4212	8.91	No	No	0	0	6
2	L:L:?7	L:L:R8	25.5673	12.35	Yes	Yes	1	0	0
3	L:L:?7	R:R:F257	18.6533	6.19	Yes	Yes	0	0	5
4	R:R:F257	R:R:F280	32.3192	4.29	Yes	Yes	0	5	4
5	R:R:F280	R:R:H260	43.1972	16.97	Yes	Yes	0	4	4
6	R:R:F283	R:R:H260	23.7844	6.79	Yes	Yes	2	5	4
7	R:R:F283	R:R:L282	33.8103	6.09	Yes	Yes	2	5	3
8	R:R:L282	R:R:V38	29.7212	8.94	Yes	No	0	3	5
9	R:R:I40	R:R:V38	28.3042	3.07	Yes	No	0	6	5
10	R:R:F45	R:R:I40	21.0151	5.02	Yes	Yes	3	6	6
11	L:L:?7	R:R:D121	20.8484	14.95	Yes	Yes	1	0	5
12	L:L:?7	R:R:L284	14.4346	4.69	Yes	No	0	0	4
13	R:R:F280	R:R:L284	13.5547	10.96	Yes	No	0	4	4
14	R:R:F45	R:R:T95	13.8325	5.19	Yes	Yes	3	6	5
15	L:L:?7	R:R:M128	54.7235	8.39	Yes	Yes	1	0	5
16	L:L:R8	R:R:I180	12.4711	8.77	Yes	Yes	1	0	5
17	R:R:D121	R:R:I180	12.1237	4.2	Yes	Yes	1	5	5
18	L:L:W9	R:R:L192	10.5677	4.56	Yes	No	1	0	5
19	R:R:F277	R:R:H260	25.9933	9.05	Yes	Yes	2	3	4
20	R:R:M128	R:R:W254	54.756	5.82	Yes	Yes	1	5	7
21	R:R:S131	R:R:W254	73.7612	4.94	No	Yes	1	9	7
22	R:R:D84	R:R:S131	71.3809	5.89	Yes	No	1	9	9
23	R:R:D84	R:R:N56	100	6.73	Yes	Yes	0	9	9
24	R:R:N56	R:R:P295	91.6366	6.52	Yes	No	0	9	9
25	R:R:E55	R:R:P295	90.7474	7.86	Yes	No	0	8	9
26	R:R:E55	R:R:I292	12.4062	4.1	Yes	No	0	8	5
27	R:R:E55	R:R:F300	81.4254	4.66	Yes	Yes	0	8	5
28	R:R:F300	R:R:L305	66.9167	6.09	Yes	No	0	5	8
29	R:R:L305	R:R:L69	59.1553	4.15	No	Yes	0	8	8
30	R:R:F300	R:R:L309	11.4476	8.53	Yes	Yes	0	5	6
31	R:R:T308	R:R:T62	13.2352	4.71	Yes	No	0	8	8
32	R:R:L69	R:R:Y74	49.2637	10.55	Yes	Yes	0	8	8
33	R:R:M73	R:R:Y74	45.4432	8.38	No	Yes	0	8	8
34	R:R:D141	R:R:M73	44.1558	5.54	Yes	No	0	9	8
35	R:R:D141	R:R:V156	20.3482	4.38	Yes	Yes	8	9	7
36	R:R:P72	R:R:V156	12.3136	3.53	Yes	Yes	0	7	7
37	R:R:F179	R:R:L192	18.1161	6.09	Yes	No	0	5	5
38	R:R:F250	R:R:W254	23.0434	4.01	Yes	Yes	1	8	7
39	R:R:F250	R:R:L135	25.1042	7.31	Yes	Yes	1	8	8
40	R:R:E94	R:R:I120	20.3899	5.47	No	No	0	4	5
41	R:R:I120	R:R:L116	17.4586	7.14	No	No	0	5	3
42	R:R:L116	R:R:V97	15.9118	4.47	No	No	0	3	4
43	R:R:L101	R:R:V97	14.3697	2.98	No	No	0	3	4
44	R:R:I180	R:R:V122	21.9274	4.61	Yes	No	0	5	5
45	R:R:F257	R:R:I287	21.1401	5.02	Yes	No	0	5	7
46	R:R:F196	R:R:W254	25.5719	4.01	Yes	Yes	1	7	7
47	R:R:F196	R:R:L132	14.5411	3.65	Yes	Yes	1	7	7
48	R:R:F195	R:R:L132	30.8743	8.53	No	Yes	1	4	7
49	R:R:F257	R:R:F258	11.3735	9.65	Yes	No	0	5	5
50	R:R:F196	R:R:F258	11.5449	27.86	Yes	No	0	7	5
51	R:R:F250	R:R:L132	22.3673	3.65	Yes	Yes	1	8	7
52	R:R:C133	R:R:F195	28.0078	5.59	No	No	0	4	4
53	R:R:C133	R:R:I168	25.0903	6.55	No	No	0	4	6
54	R:R:L135	R:R:Y298	10.3686	4.69	Yes	Yes	1	8	9
55	R:R:D294	R:R:Y298	15.6942	4.6	Yes	Yes	1	9	9
56	R:R:F250	R:R:M203	15.2728	7.46	Yes	No	0	8	8
57	R:R:M203	R:R:Y207	13.1657	7.18	No	Yes	0	8	8
58	R:R:D141	R:R:Y152	18.6441	10.34	Yes	Yes	8	9	8
59	R:R:S145	R:R:Y152	16.537	8.9	No	Yes	0	9	8
60	R:R:I146	R:R:S145	15.0551	3.1	No	No	0	8	9
61	R:R:F147	R:R:I146	13.564	11.3	Yes	No	0	6	8
62	R:R:T177	R:R:V122	19.2183	3.17	No	No	0	4	5
63	R:R:L178	R:R:T177	16.5	1.47	No	No	0	5	4
64	R:R:L178	R:R:Y182	11.0355	3.52	No	No	0	5	4
65	R:R:C273	R:R:F277	18.7969	4.19	Yes	Yes	2	4	3
66	R:R:F196	R:R:G255	22.4183	4.52	Yes	No	0	7	5
67	R:R:L246	R:R:Y298	11.443	5.86	No	Yes	0	8	9
68	R:R:G255	R:R:P256	21.2605	4.06	No	No	0	5	9
69	R:R:F283	R:R:P256	20.7789	8.67	Yes	No	0	5	9
70	L:L:?7	L:L:W9	13.9622	6.76	Yes	Yes	1	0	0
71	R:R:F257	R:R:L261	15.2867	8.53	Yes	Yes	0	5	5
72	R:R:F134	R:R:I168	22.1914	12.56	Yes	No	0	8	6
73	R:R:F196	R:R:F250	10.5724	6.43	Yes	Yes	1	7	8
74	L:L:?7	R:R:E94	20.1815	7.86	Yes	No	1	0	4
75	R:R:I287	R:R:W254	20.6493	11.74	No	Yes	1	7	7
76	R:R:D84	R:R:L80	11.2531	9.5	Yes	Yes	1	9	9
77	R:R:D294	R:R:D84	18.2967	6.65	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?4	R:R:D117	8.91	0	No	No	0	6	0	1
L:L:H6	R:R:D42	7.56	3	Yes	Yes	0	3	0	1
L:L:H6	R:R:F45	6.79	3	Yes	Yes	0	6	0	1
L:L:H6	R:R:T95	8.21	3	Yes	Yes	0	5	0	1
L:L:H6	R:R:I98	5.3	3	Yes	No	0	3	0	1
L:L:?7	R:R:E94	7.86	1	Yes	No	0	4	0	1
L:L:?7	R:R:D121	14.95	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:T124	11.24	1	Yes	No	0	5	0	1
L:L:?7	R:R:C125	6.72	1	Yes	No	0	4	0	1
L:L:?7	R:R:M128	8.39	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:F257	6.19	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:L284	4.69	1	Yes	No	0	4	0	1
L:L:R8	R:R:D117	7.15	1	Yes	No	0	6	0	1
L:L:R8	R:R:N118	8.44	1	Yes	Yes	0	4	0	1
L:L:R8	R:R:D121	14.29	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:I180	8.77	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:Y183	11.32	1	Yes	No	0	3	0	1
L:L:W9	R:R:Y183	5.79	1	Yes	No	0	3	0	1
L:L:W9	R:R:L189	13.67	1	Yes	No	0	4	0	1
L:L:W9	R:R:L192	4.56	1	Yes	No	0	5	0	1
L:L:W9	R:R:L261	4.56	1	Yes	Yes	0	5	0	1
L:L:G10	R:R:F280	10.54	0	No	Yes	0	4	0	1
L:L:P12	R:R:F277	8.67	0	No	Yes	0	3	0	1
R:R:F45	R:R:I40	5.02	3	Yes	Yes	6	6	1	2
R:R:I40	R:R:N281	4.25	3	Yes	No	6	4	2	2
R:R:D42	R:R:T95	4.34	3	Yes	Yes	3	5	1	1
R:R:D42	R:R:I98	4.2	3	Yes	No	3	3	1	1
R:R:D42	R:R:L99	9.5	3	Yes	No	3	4	1	2
R:R:F45	R:R:T95	5.19	3	Yes	Yes	6	5	1	1
R:R:F45	R:R:N281	7.25	3	Yes	No	6	4	1	2
R:R:L46	R:R:T95	5.9	0	No	Yes	5	5	2	1
R:R:S90	R:R:T124	4.8	0	No	No	5	5	2	1
R:R:E94	R:R:I120	5.47	1	No	No	4	5	1	2
R:R:D121	R:R:E94	6.5	1	Yes	No	5	4	1	1
R:R:N118	R:R:Q115	6.6	1	Yes	No	4	1	1	2
R:R:D117	R:R:D121	10.65	1	No	Yes	6	5	1	1
R:R:I180	R:R:N118	4.25	1	Yes	Yes	5	4	1	1
R:R:D121	R:R:I180	4.2	1	Yes	Yes	5	5	1	1
R:R:I180	R:R:V122	4.61	1	Yes	No	5	5	1	2
R:R:M128	R:R:W254	5.82	1	Yes	Yes	5	7	1	2
R:R:I287	R:R:M128	4.37	1	No	Yes	7	5	2	1
R:R:F179	R:R:L192	6.09	0	Yes	No	5	5	2	1
R:R:L189	R:R:L261	5.54	1	No	Yes	4	5	1	1
R:R:L189	R:R:V265	4.47	1	No	Yes	4	4	1	2
R:R:L192	R:R:L261	4.15	1	No	Yes	5	5	1	1
R:R:I287	R:R:W254	11.74	1	No	Yes	7	7	2	2
R:R:F257	R:R:F258	9.65	0	Yes	No	5	5	1	2
R:R:F257	R:R:L261	8.53	0	Yes	Yes	5	5	1	1
R:R:F257	R:R:F280	4.29	0	Yes	Yes	5	4	1	1
R:R:F257	R:R:I287	5.02	0	Yes	No	5	7	1	2
R:R:H260	R:R:I264	9.28	2	Yes	No	4	4	2	2
R:R:F277	R:R:H260	9.05	2	Yes	Yes	3	4	1	2
R:R:F280	R:R:H260	16.97	0	Yes	Yes	4	4	1	2
R:R:F277	R:R:I264	11.3	2	Yes	No	3	4	1	2
R:R:C273	R:R:F277	4.19	2	Yes	Yes	4	3	2	1
R:R:F277	R:R:G274	6.02	2	Yes	No	3	2	1	2
R:R:F280	R:R:L284	10.96	0	Yes	No	4	4	1	1
R:R:C125	R:R:S176	3.44	0	No	No	4	7	1	2
R:R:M128	R:R:V87	3.04	1	Yes	No	5	8	1	2
L:L:P12	R:R:P268	1.95	0	No	No	0	3	0	1
L:L:Y2	R:R:A110	1.33	0	No	No	0	3	0	1
R:R:N118	R:R:Q114	1.32	1	Yes	No	4	2	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F4F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.93
Number of Linked Nodes	242
Number of Links	285
Number of Hubs	49
Number of Links mediated by Hubs	174
Number of Communities	9
Number of Nodes involved in Communities	65
Number of Links involved in Communities	90

Path Summary
Number Of Nodes in MetaPath	78
Number Of Links MetaPath	77
Number of Shortest Paths	48966
Length Of Smallest Path	3
Average Path Length	13.3032
Length of Longest Path	31
Minimum Path Strength	1.3
Average Path Strength	6.68089
Maximum Path Strength	18.755
Minimum Path Correlation	0.7
Average Path Correlation	0.929707
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	51.7401
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	55.16
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>7F4F_nogp_Chain_R L E V S I S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T L K E V L T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	9K3P	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3P (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-		2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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