psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N281	R:R:S41	5.96	No	No	0	4	5
2	R:R:D42	R:R:G43	5.03	No	No	0	3	5
3	R:R:L44	R:R:L48	5.54	No	No	0	5	6
4	R:R:F45	R:R:N91	13.29	No	Yes	4	6	7
5	R:R:F45	R:R:T95	3.89	No	No	0	6	5
6	R:R:F45	R:R:L284	6.09	No	No	4	6	4
7	R:R:L46	R:R:V92	7.45	No	No	0	5	6
8	R:R:L46	R:R:T95	5.9	No	No	0	5	5
9	R:R:I288	R:R:L48	4.28	No	No	0	6	6
10	R:R:I292	R:R:L48	5.71	No	No	0	5	6
11	R:R:G49	R:R:S52	3.71	No	No	5	6	8
12	R:R:G49	R:R:S88	3.71	No	Yes	5	6	9
13	R:R:L50	R:R:V51	4.47	No	No	0	5	5
14	R:R:I292	R:R:V51	3.07	No	No	0	5	5
15	R:R:S52	R:R:S88	6.52	No	Yes	5	8	9
16	R:R:A291	R:R:S52	3.42	No	No	0	9	8
17	R:R:L53	R:R:L85	4.15	Yes	No	0	5	7
18	R:R:L53	R:R:S88	3	Yes	Yes	0	5	9
19	R:R:E55	R:R:F300	7	No	No	0	8	5
20	R:R:N56	R:R:V60	4.43	No	No	0	9	7
21	R:R:A81	R:R:N56	4.69	No	No	0	9	9
22	R:R:L85	R:R:N56	17.85	No	No	0	7	9
23	R:R:F300	R:R:L58	3.65	No	No	0	5	7
24	R:R:A81	R:R:V59	3.39	No	No	0	9	9
25	R:R:A299	R:R:V59	3.39	No	No	0	8	9
26	R:R:F300	R:R:V59	5.24	No	No	0	5	9
27	R:R:C78	R:R:V60	5.12	No	No	0	6	7
28	R:R:T308	R:R:T62	3.14	No	No	0	8	8
29	R:R:C78	R:R:I63	4.91	No	No	0	6	8
30	R:R:N66	R:R:N68	14.98	No	No	0	8	7
31	R:R:H70	R:R:R67	14.67	No	No	0	8	7
32	R:R:L69	R:R:N68	8.24	No	No	0	8	7
33	R:R:L69	R:R:Y74	14.07	No	Yes	0	8	8
34	R:R:E304	R:R:L69	7.95	No	No	0	7	8
35	R:R:H70	R:R:L158	19.28	No	Yes	1	8	3
36	R:R:H70	R:R:R162	10.16	No	No	1	8	1
37	R:R:P72	R:R:S71	3.56	Yes	No	0	7	7
38	R:R:S71	R:R:Y74	5.09	No	Yes	0	7	8
39	R:R:P72	R:R:Y152	4.17	Yes	Yes	1	7	8
40	R:R:P72	R:R:V156	3.53	Yes	No	1	7	7
41	R:R:L158	R:R:P72	3.28	Yes	Yes	1	3	7
42	R:R:A161	R:R:P72	3.74	No	Yes	0	6	7
43	R:R:D141	R:R:M73	11.09	No	No	1	9	8
44	R:R:M73	R:R:S145	3.07	No	No	0	8	9
45	R:R:M73	R:R:Y152	9.58	No	Yes	1	8	8
46	R:R:S302	R:R:Y74	5.09	No	Yes	6	8	8
47	R:R:L305	R:R:Y74	4.69	No	Yes	6	8	8
48	R:R:C75	R:R:R162	5.57	No	No	0	4	1
49	R:R:A137	R:R:F76	4.16	No	No	0	7	7
50	R:R:C79	R:R:F134	8.38	No	Yes	3	9	8
51	R:R:C79	R:R:V165	8.54	No	No	0	9	7
52	R:R:C79	R:R:W169	5.22	No	Yes	3	9	9
53	R:R:D84	R:R:L80	9.5	Yes	No	0	9	9
54	R:R:F134	R:R:L80	4.87	Yes	No	0	8	9
55	R:R:L82	R:R:W169	3.42	No	Yes	0	6	9
56	R:R:S130	R:R:S83	6.52	No	No	3	7	8
57	R:R:F134	R:R:S83	5.28	Yes	No	3	8	8
58	R:R:S83	R:R:W169	4.94	No	Yes	3	8	9
59	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
60	R:R:A291	R:R:D84	4.63	No	Yes	0	9	9
61	R:R:D84	R:R:P295	3.22	Yes	No	0	9	9
62	R:R:I123	R:R:L86	4.28	Yes	No	7	4	7
63	R:R:L86	R:R:S126	3	No	No	7	7	5
64	R:R:L86	R:R:S127	4.5	No	No	0	7	7
65	R:R:S127	R:R:V87	8.08	No	No	0	7	8
66	R:R:G89	R:R:S88	3.71	No	Yes	0	3	9
67	R:R:I123	R:R:S90	12.39	Yes	No	0	4	5
68	R:R:S90	R:R:T124	6.4	No	No	0	5	5
69	R:R:N91	R:R:T124	5.85	Yes	No	0	7	5
70	R:R:L284	R:R:N91	12.36	No	Yes	4	4	7
71	R:R:I288	R:R:N91	7.08	No	Yes	0	6	7
72	R:R:E94	R:R:I120	16.4	No	Yes	0	4	5
73	R:R:L99	R:R:T95	4.42	No	No	0	4	5
74	R:R:L116	R:R:V97	5.96	No	No	0	3	4
75	R:R:R109	R:R:V112	6.54	No	No	0	3	3
76	R:R:Q114	R:R:Q115	11.52	No	No	0	2	1
77	R:R:A181	R:R:N118	4.69	No	No	0	3	4
78	R:R:D121	R:R:I180	9.8	No	Yes	0	5	5
79	R:R:I180	R:R:V122	4.61	Yes	No	0	5	5
80	R:R:I123	R:R:S126	3.1	Yes	No	7	4	5
81	R:R:C125	R:R:S176	6.89	No	No	0	4	7
82	R:R:C125	R:R:F179	8.38	No	Yes	8	4	5
83	R:R:C125	R:R:I180	3.27	No	Yes	8	4	5
84	R:R:S126	R:R:S176	3.26	No	No	0	5	7
85	R:R:M128	R:R:W254	3.49	No	Yes	0	5	7
86	R:R:F257	R:R:M128	3.73	No	No	0	5	5
87	R:R:I287	R:R:M128	7.29	No	No	0	7	5
88	R:R:F195	R:R:L129	3.65	No	No	0	4	5
89	R:R:S130	R:R:W169	7.41	No	Yes	3	7	9
90	R:R:S130	R:R:S172	3.26	No	No	0	7	7
91	R:R:S131	R:R:W254	4.94	No	Yes	0	9	7
92	R:R:F195	R:R:L132	7.31	No	No	0	4	7
93	R:R:L132	R:R:M199	14.14	No	No	0	7	7
94	R:R:L132	R:R:W254	3.42	No	Yes	0	7	7
95	R:R:C133	R:R:I168	3.27	No	No	0	4	6
96	R:R:F134	R:R:I168	10.05	Yes	No	0	8	6
97	R:R:F134	R:R:W169	13.03	Yes	Yes	3	8	9
98	R:R:D294	R:R:L135	8.14	No	No	2	9	8
99	R:R:L135	R:R:Y298	4.69	No	Yes	2	8	9
100	R:R:I138	R:R:R142	5.01	No	No	2	9	9
101	R:R:I138	R:R:Y298	4.84	No	Yes	2	9	9
102	R:R:A139	R:R:Y207	5.34	No	Yes	0	9	8
103	R:R:I144	R:R:V140	3.07	No	No	0	6	6
104	R:R:D141	R:R:Y152	10.34	No	Yes	1	9	8
105	R:R:R142	R:R:Y207	7.2	No	Yes	2	9	8
106	R:R:R142	R:R:Y298	6.17	No	Yes	2	9	9
107	R:R:F147	R:R:Y143	20.63	Yes	Yes	10	6	7
108	R:R:L206	R:R:Y143	10.55	No	Yes	0	5	7
109	R:R:H209	R:R:Y143	7.62	No	Yes	10	6	7
110	R:R:M210	R:R:Y143	5.99	No	Yes	0	9	7
111	R:R:I144	R:R:Y148	3.63	No	No	0	6	6
112	R:R:F147	R:R:I146	5.02	Yes	No	0	6	8
113	R:R:I146	R:R:M210	7.29	No	No	0	8	9
114	R:R:F147	R:R:H209	10.18	Yes	No	10	6	6
115	R:R:F147	R:R:R213	3.21	Yes	No	0	6	6
116	R:R:H153	R:R:Y152	4.36	No	Yes	0	5	8
117	R:R:V156	R:R:Y152	10.09	No	Yes	1	7	8
118	R:R:I155	R:R:V156	3.07	No	No	0	5	7
119	R:R:P159	R:R:T157	10.49	No	No	0	4	8
120	R:R:L158	R:R:R162	4.86	Yes	No	1	3	1
121	R:R:A164	R:R:R163	4.15	No	No	0	6	3
122	R:R:S172	R:R:V173	3.23	No	No	0	7	3
123	R:R:F179	R:R:I180	21.35	Yes	Yes	8	5	5
124	R:R:F179	R:R:V188	5.24	Yes	No	0	5	4
125	R:R:F179	R:R:L189	3.65	Yes	Yes	0	5	4
126	R:R:H185	R:R:Y182	4.36	Yes	No	0	4	4
127	R:R:D184	R:R:Y183	6.9	No	No	0	4	3
128	R:R:D184	R:R:L189	5.43	No	Yes	0	4	4
129	R:R:H185	R:R:V186	5.54	Yes	No	0	4	1
130	R:R:L189	R:R:L261	4.15	Yes	No	0	4	5
131	R:R:L189	R:R:V265	4.47	Yes	No	0	4	4
132	R:R:F196	R:R:F250	3.22	No	Yes	9	7	8
133	R:R:F196	R:R:W254	9.02	No	Yes	9	7	7
134	R:R:F196	R:R:F258	21.43	No	Yes	0	7	5
135	R:R:F258	R:R:L197	3.65	Yes	No	0	5	4
136	R:R:F250	R:R:M199	6.22	Yes	No	0	8	7
137	R:R:F250	R:R:L200	9.74	Yes	No	0	8	5
138	R:R:M203	R:R:Y207	4.79	No	Yes	2	8	8
139	R:R:M203	R:R:Y298	3.59	No	Yes	2	8	9
140	R:R:A204	R:R:L247	3.15	No	Yes	0	4	7
141	R:R:L246	R:R:Y207	5.86	No	Yes	2	8	8
142	R:R:L247	R:R:Y207	3.52	Yes	Yes	0	7	8
143	R:R:Y207	R:R:Y298	4.96	Yes	Yes	2	8	9
144	R:R:L243	R:R:V208	5.96	No	No	0	8	4
145	R:R:C215	R:R:L211	3.17	No	Yes	0	5	6
146	R:R:L211	R:R:L243	4.15	Yes	No	0	6	8
147	R:R:Q216	R:R:R213	4.67	No	No	0	4	6
148	R:R:H217	R:R:R213	7.9	No	No	0	8	6
149	R:R:K238	R:R:V241	6.07	No	No	0	8	7
150	R:R:K238	R:R:T242	3	No	No	0	8	9
151	R:R:G239	R:R:T242	3.64	No	No	0	8	9
152	R:R:I245	R:R:V241	3.07	No	No	0	7	7
153	R:R:L243	R:R:L247	4.15	No	Yes	0	8	7
154	R:R:L246	R:R:Y298	7.03	No	Yes	2	8	9
155	R:R:I249	R:R:I293	4.42	No	No	0	6	5
156	R:R:F250	R:R:W254	18.04	Yes	Yes	9	8	7
157	R:R:C253	R:R:N290	9.45	No	No	0	8	9
158	R:R:N290	R:R:W254	18.08	No	Yes	0	9	7
159	R:R:G255	R:R:P256	4.06	No	No	0	5	9
160	R:R:F283	R:R:P256	10.11	No	No	0	5	9
161	R:R:L286	R:R:P256	3.28	No	No	0	7	9
162	R:R:F257	R:R:L261	10.96	No	No	0	5	5
163	R:R:F257	R:R:F280	5.36	No	No	0	5	4
164	R:R:F258	R:R:T262	3.89	Yes	No	0	5	4
165	R:R:H260	R:R:L261	5.14	Yes	No	0	4	5
166	R:R:F277	R:R:H260	24.89	Yes	Yes	0	3	4
167	R:R:F280	R:R:H260	19.23	No	Yes	0	4	4
168	R:R:F283	R:R:H260	6.79	No	Yes	0	5	4
169	R:R:C273	R:R:L263	6.35	No	No	0	4	4
170	R:R:F277	R:R:L263	4.87	Yes	No	0	3	4
171	R:R:F277	R:R:I264	6.28	Yes	No	0	3	4
172	R:R:C267	R:R:H270	4.42	No	No	11	3	4
173	R:R:C267	R:R:C273	5.46	No	No	11	3	4
174	R:R:E269	R:R:P268	6.29	No	No	0	1	3
175	R:R:H270	R:R:P271	3.05	No	No	0	4	3
176	R:R:C273	R:R:H270	5.9	No	No	11	4	4
177	R:R:F277	R:R:G274	4.52	Yes	No	0	3	2
178	R:R:C289	R:R:I292	3.27	No	No	0	4	5
179	R:R:D294	R:R:N290	6.73	No	No	0	9	9
180	R:R:D294	R:R:Y298	3.45	No	Yes	2	9	9
181	R:R:I297	R:R:Y298	6.04	No	Yes	0	8	9
182	R:R:H301	R:R:R306	3.39	No	No	0	7	9
183	R:R:E304	R:R:S302	7.19	No	No	0	7	8
184	R:R:L305	R:R:S302	4.5	No	No	6	8	8
185	R:R:L93	R:R:V97	2.98	No	No	0	8	4
186	R:R:L206	R:R:V140	2.98	No	No	0	5	6
187	R:R:N118	R:R:V122	2.96	No	No	0	4	5
188	R:R:L58	R:R:T62	2.95	No	No	0	7	8
189	R:R:L305	R:R:T62	2.95	No	No	0	8	8
190	R:R:I293	R:R:I297	2.94	No	No	0	5	8
191	R:R:I120	R:R:L116	2.85	Yes	No	0	5	3
192	R:R:I245	R:R:L246	2.85	No	No	0	7	8
193	R:R:I276	R:R:L263	2.85	No	No	0	4	4
194	R:R:D117	R:R:I120	2.8	No	Yes	0	6	5
195	R:R:A164	R:R:F76	2.77	No	No	0	6	7
196	R:R:H185	R:R:V188	2.77	Yes	No	0	4	4
197	R:R:H225	R:R:I221	2.65	No	No	0	4	7
198	R:R:F76	R:R:V165	2.62	No	No	0	7	7
199	R:R:F258	R:R:V193	2.62	Yes	No	0	5	4
200	R:R:F175	R:R:L129	2.44	No	No	0	4	5
201	R:R:F195	R:R:L192	2.44	No	No	0	4	5
202	R:R:F251	R:R:L200	2.44	No	No	0	6	5
203	R:R:F283	R:R:L259	2.44	No	No	0	5	6
204	R:R:M210	R:R:Y207	2.39	No	Yes	0	9	8
205	R:R:A139	R:R:G136	1.95	No	No	0	9	7
206	R:R:G104	R:R:L101	1.71	No	No	0	5	3
207	R:R:G248	R:R:L247	1.71	No	Yes	0	6	7
208	R:R:L158	R:R:P159	1.64	Yes	No	0	3	4
209	R:R:A299	R:R:I77	1.62	No	No	0	8	7
210	R:R:V170	R:R:V174	1.6	No	No	0	4	4
211	R:R:V173	R:R:V174	1.6	No	No	0	3	4
212	R:R:V201	R:R:V205	1.6	No	No	0	4	4
213	R:R:T177	R:R:V122	1.59	No	No	0	4	5
214	R:R:C267	R:R:L266	1.59	No	No	0	3	3
215	R:R:A57	R:R:L53	1.58	No	Yes	0	5	5
216	R:R:A103	R:R:L100	1.58	No	No	0	5	4
217	R:R:A214	R:R:L211	1.58	No	Yes	0	8	6
218	R:R:A240	R:R:L211	1.58	No	Yes	0	7	6
219	R:R:A111	R:R:Q114	1.52	No	No	0	2	2
220	R:R:I276	R:R:T272	1.52	No	No	0	4	4
221	R:R:L44	R:R:S47	1.5	No	No	0	5	3
222	R:R:L53	R:R:V54	1.49	Yes	No	0	5	4
223	R:R:L202	R:R:V201	1.49	No	No	0	5	4
224	R:R:L206	R:R:V205	1.49	No	No	0	5	4
225	R:R:D42	R:R:S41	1.47	No	No	0	3	5
226	R:R:I120	R:R:I123	1.47	Yes	Yes	0	5	4
227	R:R:A187	R:R:H185	1.46	No	Yes	0	4	4
228	R:R:I297	R:R:L296	1.43	No	No	0	8	5
229	R:R:I276	R:R:N279	1.42	No	No	0	4	4
230	R:R:A171	R:R:F175	1.39	No	No	0	3	4
231	R:R:L101	R:R:L113	1.38	No	No	0	3	6
232	R:R:A167	R:R:R163	1.38	No	No	0	3	3
233	R:R:L282	R:R:N279	1.37	No	No	0	3	4
234	R:R:R160	R:R:T157	1.29	No	No	0	7	8
235	R:R:I155	R:R:R151	1.25	No	No	0	5	6
236	R:R:L178	R:R:Y182	1.17	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L53	2.555	4	0	5
2	R:R:P72	3.656	5	1	7
3	R:R:Y74	7.235	4	6	8
4	R:R:D84	5.4425	4	0	9
5	R:R:S88	4.235	4	5	9
6	R:R:N91	9.645	4	4	7
7	R:R:I120	5.88	4	0	5
8	R:R:I123	5.31	4	7	4
9	R:R:F134	8.322	5	3	8
10	R:R:Y143	11.1975	4	10	7
11	R:R:F147	9.76	4	10	6
12	R:R:Y152	7.708	5	1	8
13	R:R:L158	7.265	4	1	3
14	R:R:W169	6.804	5	3	9
15	R:R:F179	9.655	4	8	5
16	R:R:I180	9.7575	4	8	5
17	R:R:H185	3.5325	4	0	4
18	R:R:L189	4.425	4	0	4
19	R:R:Y207	4.86571	7	2	8
20	R:R:L211	2.62	4	0	6
21	R:R:L247	3.1325	4	0	7
22	R:R:F250	9.305	4	9	8
23	R:R:W254	9.49833	6	9	7
24	R:R:F258	7.8975	4	0	5
25	R:R:H260	14.0125	4	0	4
26	R:R:F277	10.14	4	0	3
27	R:R:Y298	5.09625	8	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I288	R:R:N91	12.9945	7.08	No	Yes	0	6	7
2	R:R:I288	R:R:L48	11.4247	4.28	No	No	0	6	6
3	R:R:A291	R:R:S52	68.4294	3.42	No	No	0	9	8
4	R:R:A291	R:R:D84	69.5077	4.63	No	Yes	0	9	9
5	R:R:D84	R:R:S131	91.9765	4.42	Yes	No	0	9	9
6	R:R:S131	R:R:W254	92.6267	4.94	No	Yes	0	9	7
7	R:R:M128	R:R:W254	100	3.49	No	Yes	0	5	7
8	R:R:F257	R:R:M128	99.1279	3.73	No	No	0	5	5
9	R:R:F257	R:R:L261	76.2229	10.96	No	No	0	5	5
10	R:R:L189	R:R:L261	61.0323	4.15	Yes	No	0	4	5
11	R:R:F179	R:R:L189	57.0602	3.65	Yes	Yes	0	5	4
12	R:R:C125	R:R:F179	41.4969	8.38	No	Yes	8	4	5
13	R:R:C125	R:R:S176	41.6871	6.89	No	No	0	4	7
14	R:R:S126	R:R:S176	40.4503	3.26	No	No	0	5	7
15	R:R:I123	R:R:S126	34.7736	3.1	Yes	No	7	4	5
16	R:R:I123	R:R:S90	26.219	12.39	Yes	No	0	4	5
17	R:R:S90	R:R:T124	24.7919	6.4	No	No	0	5	5
18	R:R:N91	R:R:T124	23.3489	5.85	Yes	No	0	7	5
19	R:R:S52	R:R:S88	65.8686	6.52	No	Yes	5	8	9
20	R:R:L53	R:R:S88	63.9578	3	Yes	Yes	0	5	9
21	R:R:L53	R:R:L85	60.4376	4.15	Yes	No	0	5	7
22	R:R:F300	R:R:V59	49.0209	5.24	No	No	0	5	9
23	R:R:A81	R:R:V59	52.9692	3.39	No	No	0	9	9
24	R:R:A81	R:R:N56	54.2535	4.69	No	No	0	9	9
25	R:R:L85	R:R:N56	59.2325	17.85	No	No	0	7	9
26	R:R:F300	R:R:L58	46.3094	3.65	No	No	0	5	7
27	R:R:L58	R:R:T62	44.9298	2.95	No	No	0	7	8
28	R:R:L305	R:R:T62	42.1232	2.95	No	No	0	8	8
29	R:R:L305	R:R:Y74	37.4296	4.69	No	Yes	6	8	8
30	R:R:L158	R:R:P72	14.1996	3.28	Yes	Yes	1	3	7
31	R:R:P72	R:R:S71	30.4051	3.56	Yes	No	0	7	7
32	R:R:S71	R:R:Y74	31.9512	5.09	No	Yes	0	7	8
33	R:R:C79	R:R:V165	10.505	8.54	No	No	0	9	7
34	R:R:C79	R:R:F134	11.7577	8.38	No	Yes	3	9	8
35	R:R:F134	R:R:L80	37.9212	4.87	Yes	No	0	8	9
36	R:R:D84	R:R:L80	39.38	9.5	Yes	No	0	9	9
37	R:R:F134	R:R:W169	11.7022	13.03	Yes	Yes	3	8	9
38	R:R:F134	R:R:S83	10.0848	5.28	Yes	No	3	8	8
39	R:R:L132	R:R:W254	12.3048	3.42	No	Yes	0	7	7
40	R:R:S130	R:R:S172	13.7239	3.26	No	No	0	7	7
41	R:R:D294	R:R:N290	67.9854	6.73	No	No	0	9	9
42	R:R:N290	R:R:W254	70.1261	18.08	No	Yes	0	9	7
43	R:R:D294	R:R:Y298	65.4246	3.45	No	Yes	2	9	9
44	R:R:Y207	R:R:Y298	46.8802	4.96	Yes	Yes	2	8	9
45	R:R:L206	R:R:Y143	12.3127	10.55	No	Yes	0	5	7
46	R:R:M210	R:R:Y143	21.9773	5.99	No	Yes	0	9	7
47	R:R:M210	R:R:Y207	31.856	2.39	No	Yes	0	9	8
48	R:R:F147	R:R:R213	10.4099	3.21	Yes	No	0	6	6
49	R:R:S172	R:R:V173	10.3148	3.23	No	No	0	7	3
50	R:R:L247	R:R:Y207	15.9042	3.52	Yes	Yes	0	7	8
51	R:R:L243	R:R:L247	10.7429	4.15	No	Yes	0	8	7
52	R:R:F283	R:R:H260	13.8032	6.79	No	Yes	0	5	4
53	R:R:H260	R:R:L261	28.9939	5.14	Yes	No	0	4	5
54	R:R:F257	R:R:F280	23.0635	5.36	No	No	0	5	4
55	R:R:F280	R:R:H260	22.1121	19.23	No	Yes	0	4	4
56	R:R:F277	R:R:H260	35.1701	24.89	Yes	Yes	0	3	4
57	R:R:C273	R:R:L263	13.8904	6.35	No	No	0	4	4
58	R:R:F277	R:R:L263	27.3924	4.87	Yes	No	0	3	4
59	R:R:I276	R:R:L263	11.1393	2.85	No	No	0	4	4

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K3P_nogp

PDB Summary
PDB	9K3P_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	222
Number of Links	236
Number of Hubs	27
Number of Links mediated by Hubs	109
Number of Communities	11
Number of Nodes involved in Communities	45
Number of Links involved in Communities	53

Path Summary
Number Of Nodes in MetaPath	60
Number Of Links MetaPath	59
Number of Shortest Paths	24691
Length Of Smallest Path	3
Average Path Length	15.5464
Length of Longest Path	39
Minimum Path Strength	1.395
Average Path Strength	6.26289
Maximum Path Strength	18.06
Minimum Path Correlation	0.7
Average Path Correlation	0.936476
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	52.5381
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	33.8838
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multicellular organismal process • regulation of tumor necrosis factor production • regulation of cellular process • negative regulation of biological process • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • regulation of multicellular organismal process • negative regulation of macromolecule metabolic process • regulation of biosynthetic process • regulation of biological process • negative regulation of metabolic process • biological regulation • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • biosynthetic process • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • metabolic process • cellular process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • regulation of metabolic process • pigment metabolic process • pigment biosynthetic process • melanin metabolic process • secondary metabolic process • secondary metabolite biosynthetic process • phenol-containing compound metabolic process • phenol-containing compound biosynthetic process • melanin biosynthetic process • response to light stimulus • response to stimulus • response to radiation • response to abiotic stimulus • response to UV • UV protection • cellular response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • pigmentation • positive regulation of feeding behavior • positive regulation of biological process • feeding behavior • regulation of behavior • behavior • positive regulation of behavior • positive regulation of multicellular organismal process • regulation of feeding behavior • cellular response to environmental stimulus • nucleobase-containing compound metabolic process • cellular response to stress • response to stress • cellular response to light stimulus • DNA repair • primary metabolic process • DNA metabolic process • cellular response to radiation • nucleic acid metabolic process • UV-damage excision repair • DNA damage response • cellular response to abiotic stimulus • cellular response to UV • system process • sensory perception • nervous system process • sensory perception of pain • intracellular signal transduction • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • regulation of response to stimulus • regulation of cell communication • positive regulation of signaling • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cell periphery • cellular anatomical structure • plasma membrane • membrane • intracellular anatomical structure • cytoplasm • binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of chemical stimulus • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of small molecule metabolic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • negative regulation of peptide hormone secretion • negative regulation of establishment of protein localization • negative regulation of protein secretion • negative regulation of signaling • negative regulation of cell communication • negative regulation of peptide secretion • negative regulation of protein localization • negative regulation of insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>9K3P_nogp_Chain_R S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	9K3P	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3P (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-		2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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