psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y2	R:R:R109	8.23	No	No	0	0	3
2	L:L:?4	L:L:E5	4.97	Yes	No	0	0	0
3	L:L:?4	R:R:I98	8.03	Yes	No	0	0	3
4	L:L:?4	R:R:D117	12.73	Yes	No	0	0	6
5	L:L:E5	L:L:K11	5.4	No	No	0	0	0
6	L:L:H6	R:R:D42	5.04	Yes	Yes	1	0	3
7	L:L:H6	R:R:F45	18.1	Yes	No	0	0	6
8	L:L:H6	R:R:E94	7.39	Yes	No	1	0	4
9	L:L:H6	R:R:T95	6.85	Yes	No	1	0	5
10	L:L:H6	R:R:I98	5.3	Yes	No	0	0	3
11	L:L:?7	L:L:R8	11.32	Yes	Yes	1	0	0
12	L:L:?7	L:L:W9	6.76	Yes	Yes	1	0	0
13	L:L:?7	R:R:E94	12.35	Yes	No	1	0	4
14	L:L:?7	R:R:D121	18.4	Yes	Yes	1	0	5
15	L:L:?7	R:R:T124	11.24	Yes	Yes	1	0	5
16	L:L:?7	R:R:M128	4.79	Yes	Yes	1	0	5
17	L:L:?7	R:R:I180	4.84	Yes	Yes	1	0	5
18	L:L:?7	R:R:F257	6.19	Yes	Yes	0	0	5
19	L:L:R8	L:L:W9	7	Yes	Yes	1	0	0
20	L:L:R8	R:R:D117	5.96	Yes	No	1	0	6
21	L:L:R8	R:R:D121	14.29	Yes	Yes	1	0	5
22	L:L:R8	R:R:I180	5.01	Yes	Yes	1	0	5
23	L:L:R8	R:R:Y183	23.66	Yes	No	1	0	3
24	L:L:W9	R:R:Y183	5.79	Yes	No	1	0	3
25	L:L:W9	R:R:L189	10.25	Yes	Yes	1	0	4
26	L:L:W9	R:R:L261	6.83	Yes	No	1	0	5
27	L:L:G10	R:R:F280	10.54	No	Yes	0	0	4
28	L:L:P12	R:R:F277	8.67	No	Yes	0	0	3
29	R:R:E37	R:R:S39	4.31	No	No	0	2	2
30	R:R:L282	R:R:V38	13.41	No	No	0	3	5
31	R:R:I40	R:R:L44	8.56	No	No	0	6	5
32	R:R:D42	R:R:T95	5.78	Yes	No	1	3	5
33	R:R:D42	R:R:L99	6.79	Yes	No	0	3	4
34	R:R:L44	R:R:L48	5.54	No	No	0	5	6
35	R:R:F45	R:R:N91	6.04	No	Yes	0	6	7
36	R:R:F45	R:R:L284	6.09	No	No	0	6	4
37	R:R:L46	R:R:L50	5.54	No	No	1	5	5
38	R:R:L46	R:R:V92	4.47	No	No	1	5	6
39	R:R:L46	R:R:T95	4.42	No	No	1	5	5
40	R:R:L50	R:R:V92	5.96	No	No	1	5	6
41	R:R:S52	R:R:S88	4.89	No	No	0	8	9
42	R:R:I288	R:R:S52	4.64	No	No	0	6	8
43	R:R:I292	R:R:S52	4.64	No	No	0	5	8
44	R:R:L53	R:R:L85	4.15	No	No	0	5	7
45	R:R:L53	R:R:S88	6.01	No	No	0	5	9
46	R:R:A81	R:R:N56	4.69	No	No	0	9	9
47	R:R:D84	R:R:N56	8.08	Yes	No	0	9	9
48	R:R:N56	R:R:P295	6.52	No	No	0	9	9
49	R:R:L309	R:R:L58	4.15	No	No	0	6	7
50	R:R:A299	R:R:V59	5.09	No	No	0	8	9
51	R:R:C78	R:R:V60	5.12	No	No	0	6	7
52	R:R:T308	R:R:T62	6.28	No	No	0	8	8
53	R:R:I63	R:R:L69	7.14	No	Yes	0	8	8
54	R:R:C78	R:R:I63	9.82	No	No	0	6	8
55	R:R:K65	R:R:V312	4.55	No	No	0	5	7
56	R:R:N66	R:R:N68	10.9	No	No	0	8	7
57	R:R:L69	R:R:N66	9.61	Yes	No	0	8	8
58	R:R:N66	R:R:T308	10.24	No	No	0	8	8
59	R:R:H70	R:R:R67	6.77	No	No	0	8	7
60	R:R:L69	R:R:Y74	10.55	Yes	Yes	0	8	8
61	R:R:L305	R:R:L69	6.92	No	Yes	0	8	8
62	R:R:S71	R:R:Y74	6.36	No	Yes	0	7	8
63	R:R:L158	R:R:P72	6.57	No	No	0	3	7
64	R:R:M73	R:R:Y74	13.17	No	Yes	0	8	8
65	R:R:D141	R:R:M73	4.16	No	No	0	9	8
66	R:R:S302	R:R:Y74	7.63	No	Yes	0	8	8
67	R:R:C75	R:R:R162	5.57	No	No	0	4	1
68	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
69	R:R:D141	R:R:F76	5.97	No	Yes	0	9	7
70	R:R:A161	R:R:F76	4.16	No	Yes	0	6	7
71	R:R:C79	R:R:F134	11.17	No	Yes	2	9	8
72	R:R:C79	R:R:V165	8.54	No	No	2	9	7
73	R:R:D84	R:R:L80	5.43	Yes	No	0	9	9
74	R:R:L135	R:R:L80	5.54	Yes	No	0	8	9
75	R:R:I138	R:R:L80	4.28	No	No	0	9	9
76	R:R:L82	R:R:W169	6.83	No	Yes	0	6	9
77	R:R:S130	R:R:S83	4.89	No	No	2	7	8
78	R:R:F134	R:R:S83	7.93	Yes	No	2	8	8
79	R:R:S83	R:R:W169	7.41	No	Yes	2	8	9
80	R:R:D84	R:R:S131	7.36	Yes	No	0	9	9
81	R:R:A291	R:R:D84	4.63	No	Yes	0	9	9
82	R:R:S127	R:R:V87	6.46	No	No	0	7	8
83	R:R:I123	R:R:S90	6.19	No	No	0	4	5
84	R:R:S90	R:R:T124	6.4	No	Yes	0	5	5
85	R:R:N91	R:R:T124	8.77	Yes	Yes	0	7	5
86	R:R:I288	R:R:N91	5.66	No	Yes	0	6	7
87	R:R:I120	R:R:L93	5.71	No	No	0	5	8
88	R:R:D121	R:R:E94	6.5	Yes	No	1	5	4
89	R:R:E102	R:R:L101	5.3	No	No	0	3	3
90	R:R:L101	R:R:L106	4.15	No	No	0	3	3
91	R:R:A110	R:R:R109	6.91	No	No	0	3	3
92	R:R:Q114	R:R:Q115	7.68	No	No	0	2	1
93	R:R:D117	R:R:D121	9.31	No	Yes	1	6	5
94	R:R:I180	R:R:N118	4.25	Yes	No	0	5	4
95	R:R:I180	R:R:V122	4.61	Yes	No	0	5	5
96	R:R:M128	R:R:T124	4.52	Yes	Yes	1	5	5
97	R:R:C125	R:R:S176	6.89	No	No	0	4	7
98	R:R:C125	R:R:I180	6.55	No	Yes	0	4	5
99	R:R:S126	R:R:S172	4.89	No	No	0	5	7
100	R:R:S126	R:R:V173	4.85	No	No	0	5	3
101	R:R:S126	R:R:S176	4.89	No	No	0	5	7
102	R:R:M128	R:R:W254	5.82	Yes	Yes	1	5	7
103	R:R:I287	R:R:M128	4.37	Yes	Yes	1	7	5
104	R:R:L129	R:R:S172	6.01	No	No	0	5	7
105	R:R:L129	R:R:S176	4.5	No	No	0	5	7
106	R:R:F195	R:R:L129	4.87	No	No	0	4	5
107	R:R:S130	R:R:W169	11.12	No	Yes	2	7	9
108	R:R:S130	R:R:S172	6.52	No	No	0	7	7
109	R:R:S131	R:R:W254	4.94	No	Yes	0	9	7
110	R:R:F195	R:R:L132	6.09	No	No	0	4	7
111	R:R:L132	R:R:W254	15.94	No	Yes	0	7	7
112	R:R:C133	R:R:I168	8.18	No	No	0	4	6
113	R:R:F134	R:R:V165	5.24	Yes	No	2	8	7
114	R:R:F134	R:R:I168	11.3	Yes	No	0	8	6
115	R:R:F134	R:R:W169	12.03	Yes	Yes	2	8	9
116	R:R:F250	R:R:L135	6.09	Yes	Yes	1	8	8
117	R:R:L135	R:R:W254	4.56	Yes	Yes	1	8	7
118	R:R:L135	R:R:Y298	4.69	Yes	Yes	0	8	9
119	R:R:I138	R:R:Y298	4.84	No	Yes	0	9	9
120	R:R:A139	R:R:Y207	5.34	No	Yes	0	9	8
121	R:R:D141	R:R:Y152	10.34	No	Yes	0	9	8
122	R:R:R142	R:R:Y207	10.29	No	Yes	3	9	8
123	R:R:M210	R:R:R142	4.96	No	No	3	9	9
124	R:R:H301	R:R:R142	6.77	No	No	0	7	9
125	R:R:F147	R:R:Y143	16.5	Yes	No	4	6	7
126	R:R:L206	R:R:Y143	12.89	No	No	0	5	7
127	R:R:H209	R:R:Y143	7.62	No	No	4	6	7
128	R:R:I144	R:R:I155	5.89	No	No	0	6	5
129	R:R:I144	R:R:V156	4.61	No	No	0	6	7
130	R:R:S145	R:R:Y152	7.63	No	Yes	0	9	8
131	R:R:F147	R:R:I146	8.79	Yes	No	0	6	8
132	R:R:I146	R:R:M210	5.83	No	No	0	8	9
133	R:R:F147	R:R:H209	22.63	Yes	No	4	6	6
134	R:R:F147	R:R:R213	5.34	Yes	No	0	6	6
135	R:R:R151	R:R:Y148	9.26	No	No	0	6	6
136	R:R:H153	R:R:Y152	8.71	No	Yes	0	5	8
137	R:R:V156	R:R:Y152	7.57	No	Yes	0	7	8
138	R:R:P159	R:R:T157	6.99	No	No	0	4	8
139	R:R:F175	R:R:F179	4.29	No	Yes	0	4	5
140	R:R:F179	R:R:L178	4.87	Yes	No	0	5	5
141	R:R:F179	R:R:V188	11.8	Yes	No	0	5	4
142	R:R:C191	R:R:F179	5.59	No	Yes	0	4	5
143	R:R:A187	R:R:H185	5.85	No	No	0	4	4
144	R:R:L189	R:R:L261	4.15	Yes	No	1	4	5
145	R:R:I264	R:R:L189	4.28	No	Yes	0	4	4
146	R:R:F258	R:R:L192	6.09	Yes	No	0	5	5
147	R:R:T262	R:R:V193	7.93	No	No	0	4	4
148	R:R:F195	R:R:M199	8.71	No	No	0	4	7
149	R:R:F196	R:R:F250	6.43	Yes	Yes	0	7	8
150	R:R:F196	R:R:G255	4.52	Yes	No	0	7	5
151	R:R:F196	R:R:F258	27.86	Yes	Yes	0	7	5
152	R:R:F250	R:R:L200	4.87	Yes	No	0	8	5
153	R:R:F251	R:R:L200	4.87	No	No	0	6	5
154	R:R:L202	R:R:L206	6.92	No	No	0	5	5
155	R:R:M203	R:R:Y207	5.99	No	Yes	0	8	8
156	R:R:L247	R:R:M203	4.24	No	No	0	7	8
157	R:R:F250	R:R:M203	8.71	Yes	No	0	8	8
158	R:R:M210	R:R:Y207	4.79	No	Yes	3	9	8
159	R:R:L246	R:R:Y207	8.21	No	Yes	0	8	8
160	R:R:L211	R:R:L243	4.15	Yes	No	0	6	8
161	R:R:Q216	R:R:R213	8.18	No	No	0	4	6
162	R:R:H217	R:R:R213	15.8	No	No	0	8	6
163	R:R:L243	R:R:L247	5.54	No	No	0	8	7
164	R:R:L246	R:R:Y298	5.86	No	Yes	0	8	9
165	R:R:I249	R:R:I293	4.42	No	No	0	6	5
166	R:R:I249	R:R:I297	4.42	No	No	0	6	8
167	R:R:F250	R:R:W254	8.02	Yes	Yes	1	8	7
168	R:R:C253	R:R:N290	6.3	No	Yes	0	8	9
169	R:R:F258	R:R:W254	6.01	Yes	Yes	0	5	7
170	R:R:I287	R:R:W254	8.22	Yes	Yes	1	7	7
171	R:R:N290	R:R:W254	16.95	Yes	Yes	1	9	7
172	R:R:F283	R:R:P256	10.11	Yes	No	0	5	9
173	R:R:F257	R:R:F258	10.72	Yes	Yes	0	5	5
174	R:R:F257	R:R:L261	13.4	Yes	No	0	5	5
175	R:R:F257	R:R:F280	6.43	Yes	Yes	0	5	4
176	R:R:F257	R:R:I287	6.28	Yes	Yes	0	5	7
177	R:R:H260	R:R:I264	5.3	Yes	No	0	4	4
178	R:R:F277	R:R:H260	18.1	Yes	Yes	0	3	4
179	R:R:F280	R:R:H260	13.58	Yes	Yes	0	4	4
180	R:R:F283	R:R:H260	6.79	Yes	Yes	0	5	4
181	R:R:C273	R:R:L263	6.35	No	No	0	4	4
182	R:R:I276	R:R:L263	5.71	No	No	0	4	4
183	R:R:C267	R:R:H270	4.42	No	No	0	3	4
184	R:R:C267	R:R:C273	7.28	No	No	0	3	4
185	R:R:H270	R:R:P271	13.73	No	No	0	4	3
186	R:R:H270	R:R:T272	10.95	No	No	0	4	4
187	R:R:C273	R:R:F277	6.98	No	Yes	0	4	3
188	R:R:F277	R:R:G274	6.02	Yes	No	0	3	2
189	R:R:F283	R:R:N279	4.83	Yes	No	0	5	4
190	R:R:F280	R:R:L284	9.74	Yes	No	0	4	4
191	R:R:F283	R:R:L282	4.87	Yes	No	0	5	3
192	R:R:L282	R:R:L286	6.92	No	No	0	3	7
193	R:R:I287	R:R:N290	4.25	Yes	Yes	1	7	9
194	R:R:D294	R:R:N290	6.73	No	Yes	0	9	9
195	R:R:D294	R:R:Y298	4.6	No	Yes	0	9	9
196	R:R:I297	R:R:Y298	12.09	No	Yes	0	8	9
197	R:R:F300	R:R:L309	7.31	No	No	0	5	6
198	R:R:L305	R:R:S302	4.5	No	No	0	8	8
199	R:R:Q303	R:R:R306	17.52	No	No	5	6	9
200	R:R:Q303	R:R:R307	5.84	No	No	5	6	6
201	R:R:R306	R:R:R307	4.26	No	No	5	9	6
202	R:R:N118	R:R:Q114	3.96	No	No	0	4	2
203	R:R:R160	R:R:T157	3.88	No	No	0	7	8
204	R:R:A161	R:R:P72	3.74	No	No	0	6	7
205	R:R:G89	R:R:S88	3.71	No	No	0	3	9
206	R:R:F179	R:R:L192	3.65	Yes	No	0	5	5
207	R:R:G239	R:R:T242	3.64	No	No	0	8	9
208	R:R:I155	R:R:Y148	3.63	No	No	0	5	6
209	R:R:G49	R:R:I288	3.53	No	No	0	6	6
210	R:R:P295	R:R:V59	3.53	No	No	0	9	9
211	R:R:E304	R:R:Y74	3.37	No	Yes	0	7	8
212	R:R:A285	R:R:I40	3.25	No	No	0	5	6
213	R:R:V186	R:R:V265	3.21	No	No	0	1	4
214	R:R:T177	R:R:V122	3.17	No	No	0	4	5
215	R:R:C215	R:R:L211	3.17	No	Yes	0	5	6
216	R:R:A105	R:R:L100	3.15	No	No	0	4	4
217	R:R:A108	R:R:L113	3.15	No	Yes	0	1	6
218	R:R:A204	R:R:L247	3.15	No	No	0	4	7
219	R:R:A299	R:R:L305	3.15	No	No	0	8	8
220	R:R:I292	R:R:V51	3.07	No	No	0	5	5
221	R:R:I144	R:R:V140	3.07	No	No	0	6	6
222	R:R:L86	R:R:S127	3	No	No	0	7	7
223	R:R:G220	R:R:R223	3	No	No	0	5	3
224	R:R:L58	R:R:V54	2.98	No	No	0	7	4
225	R:R:L116	R:R:V97	2.98	No	No	0	3	4
226	R:R:L189	R:R:V265	2.98	Yes	No	0	4	4
227	R:R:L197	R:R:V193	2.98	No	No	0	4	4
228	R:R:L243	R:R:V208	2.98	No	No	0	8	4
229	R:R:N91	R:R:V87	2.96	Yes	No	0	7	8
230	R:R:L266	R:R:T262	2.95	No	No	0	3	4
231	R:R:I63	R:R:I77	2.94	No	No	0	8	7
232	R:R:I138	R:R:I77	2.94	No	No	0	9	7
233	R:R:I245	R:R:I297	2.94	No	No	0	7	8
234	R:R:D121	R:R:I120	2.8	Yes	No	0	5	5
235	L:L:?4	R:R:V97	2.79	Yes	No	0	0	4
236	R:R:L101	R:R:L113	2.77	No	Yes	0	3	6
237	R:R:A171	R:R:F175	2.77	No	No	0	3	4
238	R:R:L259	R:R:L263	2.77	No	No	0	6	4
239	R:R:F300	R:R:V59	2.62	No	No	0	5	9
240	R:R:F196	R:R:L197	2.44	Yes	No	0	7	4
241	R:R:L178	R:R:Y182	2.34	No	No	0	5	4
242	R:R:F300	R:R:R306	2.14	No	No	0	5	9
243	R:R:A139	R:R:G136	1.95	No	No	0	9	7
244	R:R:C267	R:R:P268	1.88	No	No	0	3	3
245	R:R:C75	R:R:C79	1.82	No	No	0	4	9
246	R:R:C253	R:R:C289	1.82	No	No	0	8	4
247	L:L:P12	L:L:V13	1.77	No	No	0	0	0
248	L:L:V13	R:R:P268	1.77	No	No	0	0	3
249	R:R:G239	R:R:K238	1.74	No	No	0	8	8
250	R:R:G274	R:R:K278	1.74	No	No	0	2	2
251	R:R:G49	R:R:L48	1.71	No	No	0	6	6
252	R:R:G239	R:R:L211	1.71	No	Yes	0	8	6
253	R:R:G248	R:R:L252	1.71	No	No	0	6	4
254	R:R:A108	R:R:V112	1.7	No	No	0	1	3
255	R:R:D42	R:R:G43	1.68	Yes	No	0	3	5
256	R:R:L158	R:R:P159	1.64	No	No	0	3	4
257	R:R:V170	R:R:V174	1.6	No	No	0	4	4
258	R:R:V201	R:R:V205	1.6	No	No	0	4	4
259	R:R:A57	R:R:L85	1.58	No	No	0	5	7
260	R:R:A214	R:R:L211	1.58	No	Yes	0	8	6
261	R:R:A240	R:R:L211	1.58	No	Yes	0	7	6
262	R:R:A240	R:R:L237	1.58	No	No	0	7	5
263	R:R:E55	R:R:P295	1.57	No	No	0	8	9
264	R:R:C275	R:R:N279	1.57	No	No	0	3	4
265	R:R:I245	R:R:V241	1.54	No	No	0	7	7
266	R:R:L116	R:R:V119	1.49	No	No	0	3	4
267	R:R:L190	R:R:V194	1.49	No	No	0	4	4
268	R:R:A212	R:R:H209	1.46	No	No	0	3	6
269	R:R:I40	R:R:N281	1.42	No	No	0	6	4
270	L:L:?4	L:L:S3	1.41	Yes	No	0	0	0
271	R:R:E311	R:R:T308	1.41	No	No	0	4	8
272	R:R:A164	R:R:F76	1.39	No	Yes	0	6	7
273	R:R:L113	R:R:L116	1.38	Yes	No	0	6	3
274	R:R:H185	R:R:V188	1.38	No	No	0	4	4
275	R:R:E37	R:R:K278	1.35	No	No	0	2	2
276	R:R:A181	R:R:Y182	1.33	No	No	0	3	4
277	R:R:D184	R:R:H185	1.26	No	No	0	4	4
278	R:R:F251	R:R:L252	1.22	No	No	0	6	4
279	L:L:Y2	R:R:L113	1.17	No	Yes	0	0	6
280	R:R:Q219	R:R:R223	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?4	5.986	5	0	0
2	L:L:H6	8.536	5	1	0
3	L:L:?7	9.48625	8	1	0
4	L:L:R8	11.2067	6	1	0
5	L:L:W9	7.326	5	1	0
6	R:R:D42	4.8225	4	1	3
7	R:R:L69	8.555	4	0	8
8	R:R:Y74	8.216	5	0	8
9	R:R:F76	3.92	4	0	7
10	R:R:D84	6.375	4	0	9
11	R:R:N91	5.8575	4	0	7
12	R:R:L113	2.1175	4	0	6
13	R:R:D121	10.26	5	1	5
14	R:R:T124	7.7325	4	1	5
15	R:R:M128	4.875	4	1	5
16	R:R:F134	9.534	5	2	8
17	R:R:L135	5.22	4	1	8
18	R:R:F147	13.315	4	4	6
19	R:R:Y152	8.5625	4	0	8
20	R:R:W169	9.3475	4	2	9
21	R:R:F179	6.04	5	0	5
22	R:R:I180	5.052	5	1	5
23	R:R:L189	5.415	4	1	4
24	R:R:F196	10.3125	4	0	7
25	R:R:Y207	6.924	5	3	8
26	R:R:L211	2.438	5	0	6
27	R:R:F250	6.824	5	1	8
28	R:R:W254	8.8075	8	1	7
29	R:R:F257	8.604	5	0	5
30	R:R:F258	12.67	4	0	5
31	R:R:H260	10.9425	4	0	4
32	R:R:F277	9.9425	4	0	3
33	R:R:F280	10.0725	4	0	4
34	R:R:F283	6.65	4	0	5
35	R:R:I287	5.78	4	1	7
36	R:R:N290	8.5575	4	1	9
37	R:R:Y298	6.416	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	R:R:V97	35.0649	2.79	Yes	No	0	0	4
2	R:R:L116	R:R:V97	32.3261	2.98	No	No	0	3	4
3	R:R:L113	R:R:L116	26.571	1.38	Yes	No	0	6	3
4	L:L:?4	R:R:D117	41.9041	12.73	Yes	No	0	0	6
5	L:L:H6	R:R:E94	11.6202	7.39	Yes	No	1	0	4
6	R:R:D117	R:R:D121	18.5693	9.31	No	Yes	1	6	5
7	L:L:?7	L:L:R8	20.3917	11.32	Yes	Yes	1	0	0
8	L:L:R8	R:R:D117	25.9007	5.96	Yes	No	1	0	6
9	L:L:?7	R:R:D121	22.5597	18.4	Yes	Yes	1	0	5
10	L:L:?7	R:R:T124	11.2694	11.24	Yes	Yes	1	0	5
11	L:L:?7	R:R:M128	48.5075	4.79	Yes	Yes	1	0	5
12	L:L:?7	R:R:F257	24.2616	6.19	Yes	Yes	0	0	5
13	R:R:F257	R:R:F280	77.566	6.43	Yes	Yes	0	5	4
14	R:R:F277	R:R:H260	53.142	18.1	Yes	Yes	0	3	4
15	R:R:F280	R:R:H260	76.0578	13.58	Yes	Yes	0	4	4
16	R:R:F277	R:R:G274	12.7723	6.02	Yes	No	0	3	2
17	R:R:F283	R:R:H260	22.2455	6.79	Yes	Yes	0	5	4
18	R:R:I288	R:R:N91	26.9376	5.66	No	Yes	0	6	7
19	R:R:G49	R:R:I288	11.0547	3.53	No	No	0	6	6
20	R:R:I288	R:R:S52	14.6575	4.64	No	No	0	6	8
21	R:R:M128	R:R:W254	70.0356	5.82	Yes	Yes	1	5	7
22	R:R:S131	R:R:W254	22.9891	4.94	No	Yes	0	9	7
23	R:R:D84	R:R:S131	21.9103	7.36	Yes	No	0	9	9
24	R:R:D84	R:R:N56	25.1623	8.08	Yes	No	0	9	9
25	R:R:N56	R:R:P295	22.1984	6.52	No	No	0	9	9
26	R:R:P295	R:R:V59	19.2553	3.53	No	No	0	9	9
27	R:R:F300	R:R:V59	14.9508	2.62	No	No	0	5	9
28	R:R:L135	R:R:W254	86.7773	4.56	Yes	Yes	1	8	7
29	R:R:L135	R:R:L80	49.7801	5.54	Yes	No	0	8	9
30	R:R:I138	R:R:L80	46.2086	4.28	No	No	0	9	9
31	R:R:I138	R:R:I77	100	2.94	No	No	0	9	7
32	R:R:I63	R:R:I77	97.4288	2.94	No	No	0	8	7
33	R:R:L135	R:R:Y298	53.7966	4.69	Yes	Yes	0	8	9
34	R:R:I138	R:R:Y298	60.2011	4.84	No	Yes	0	9	9
35	R:R:I63	R:R:L69	89.7151	7.14	No	Yes	0	8	8
36	R:R:L69	R:R:N66	15.0503	9.61	Yes	No	0	8	8
37	R:R:L69	R:R:Y74	69.4229	10.55	Yes	Yes	0	8	8
38	R:R:M73	R:R:Y74	59.7612	13.17	No	Yes	0	8	8
39	R:R:D141	R:R:M73	56.8601	4.16	No	No	0	9	8
40	R:R:D141	R:R:F76	27.2675	5.97	No	Yes	0	9	7
41	R:R:A161	R:R:F76	18.4384	4.16	No	Yes	0	6	7
42	R:R:A161	R:R:P72	15.3907	3.74	No	No	0	6	7
43	R:R:L158	R:R:P72	12.3324	6.57	No	No	0	3	7
44	R:R:C125	R:R:I180	26.0369	6.55	No	Yes	0	4	5
45	R:R:C125	R:R:S176	24.8115	6.89	No	No	0	4	7
46	R:R:S126	R:R:S176	14.2124	4.89	No	No	0	5	7
47	R:R:S126	R:R:S172	13.0184	4.89	No	No	0	5	7
48	R:R:S130	R:R:S172	45.1456	6.52	No	No	0	7	7
49	R:R:S130	R:R:S83	20.1037	4.89	No	No	2	7	8
50	R:R:F134	R:R:S83	17.6267	7.93	Yes	No	2	8	8
51	R:R:C79	R:R:F134	15.1707	11.17	No	Yes	2	9	8
52	R:R:C75	R:R:C79	10.133	1.82	No	No	0	4	9
53	R:R:L129	R:R:S176	14.5633	4.5	No	No	0	5	7
54	R:R:L129	R:R:S172	38.0917	6.01	No	No	0	5	7
55	R:R:S130	R:R:W169	22.6173	11.12	No	Yes	2	7	9
56	R:R:F134	R:R:W169	17.6634	12.03	Yes	Yes	2	8	9
57	R:R:F257	R:R:I287	39.4533	6.28	Yes	Yes	0	5	7
58	R:R:L132	R:R:W254	35.5205	15.94	No	Yes	0	7	7
59	R:R:F195	R:R:L132	33.9809	6.09	No	No	0	4	7
60	R:R:F195	R:R:L129	31.195	4.87	No	No	0	4	5
61	R:R:F134	R:R:I168	10.133	11.3	Yes	No	0	8	6
62	R:R:F250	R:R:W254	40.9615	8.02	Yes	Yes	1	8	7
63	R:R:F250	R:R:M203	49.9057	8.71	Yes	No	0	8	8
64	R:R:M203	R:R:Y207	28.3934	5.99	No	Yes	0	8	8
65	R:R:D141	R:R:Y152	27.5189	10.34	No	Yes	0	9	8
66	R:R:M210	R:R:Y207	22.2769	4.79	No	Yes	3	9	8
67	R:R:I146	R:R:M210	20.3812	5.83	No	No	0	8	9
68	R:R:F147	R:R:I146	18.5065	8.79	Yes	No	0	6	8
69	R:R:V156	R:R:Y152	18.4384	7.57	No	Yes	0	7	8
70	R:R:I144	R:R:V156	15.3907	4.61	No	No	0	6	7
71	R:R:F257	R:R:F258	46.9418	10.72	Yes	Yes	0	5	5
72	R:R:F258	R:R:L192	22.2246	6.09	Yes	No	0	5	5
73	R:R:F179	R:R:L192	20.4179	3.65	Yes	No	0	5	5
74	R:R:F196	R:R:F258	15.0765	27.86	Yes	Yes	0	7	5
75	R:R:L247	R:R:M203	27.5817	4.24	No	No	0	7	8
76	R:R:L246	R:R:Y298	11.3008	5.86	No	Yes	0	8	9
77	R:R:L243	R:R:L247	23.0886	5.54	No	No	0	8	7
78	R:R:L211	R:R:L243	18.5536	4.15	Yes	No	0	6	8
79	R:R:I287	R:R:N290	12.0706	4.25	Yes	Yes	1	7	9
80	R:R:C273	R:R:F277	28.43	6.98	No	Yes	0	4	3
81	R:R:C267	R:R:C273	15.9039	7.28	No	No	0	3	4
82	R:R:D294	R:R:N290	11.0756	6.73	No	Yes	0	9	9
83	R:R:N91	R:R:T124	29.514	8.77	Yes	Yes	0	7	5
84	L:L:?7	R:R:E94	12.5681	12.35	Yes	No	1	0	4
85	R:R:F257	R:R:L261	11.1332	13.4	Yes	No	0	5	5
86	L:L:?7	R:R:I180	25.4137	4.84	Yes	Yes	1	0	5
87	R:R:M128	R:R:T124	23.2352	4.52	Yes	Yes	1	5	5
88	R:R:F258	R:R:W254	43.9254	6.01	Yes	Yes	0	5	7
89	R:R:F196	R:R:F250	15.0136	6.43	Yes	Yes	0	7	8
90	R:R:I287	R:R:W254	29.5769	8.22	Yes	Yes	1	7	7
91	R:R:F250	R:R:L135	13.7097	6.09	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y2	R:R:R109	8.23	0	No	No	0	3	0	1
L:L:?4	R:R:I98	8.03	0	Yes	No	0	3	0	1
L:L:?4	R:R:D117	12.73	0	Yes	No	0	6	0	1
L:L:H6	R:R:D42	5.04	1	Yes	Yes	0	3	0	1
L:L:H6	R:R:F45	18.1	1	Yes	No	0	6	0	1
L:L:H6	R:R:E94	7.39	1	Yes	No	0	4	0	1
L:L:H6	R:R:T95	6.85	1	Yes	No	0	5	0	1
L:L:H6	R:R:I98	5.3	1	Yes	No	0	3	0	1
L:L:?7	R:R:E94	12.35	1	Yes	No	0	4	0	1
L:L:?7	R:R:D121	18.4	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:T124	11.24	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:M128	4.79	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:I180	4.84	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:F257	6.19	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:D117	5.96	1	Yes	No	0	6	0	1
L:L:R8	R:R:D121	14.29	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:I180	5.01	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:Y183	23.66	1	Yes	No	0	3	0	1
L:L:W9	R:R:Y183	5.79	1	Yes	No	0	3	0	1
L:L:W9	R:R:L189	10.25	1	Yes	Yes	0	4	0	1
L:L:W9	R:R:L261	6.83	1	Yes	No	0	5	0	1
L:L:G10	R:R:F280	10.54	0	No	Yes	0	4	0	1
L:L:P12	R:R:F277	8.67	0	No	Yes	0	3	0	1
R:R:D42	R:R:T95	5.78	1	Yes	No	3	5	1	1
R:R:D42	R:R:L99	6.79	1	Yes	No	3	4	1	2
R:R:F45	R:R:N91	6.04	0	No	Yes	6	7	1	2
R:R:F45	R:R:L284	6.09	0	No	No	6	4	1	2
R:R:L46	R:R:T95	4.42	1	No	No	5	5	2	1
R:R:S90	R:R:T124	6.4	0	No	Yes	5	5	2	1
R:R:N91	R:R:T124	8.77	0	Yes	Yes	7	5	2	1
R:R:D121	R:R:E94	6.5	1	Yes	No	5	4	1	1
R:R:A110	R:R:R109	6.91	0	No	No	3	3	2	1
R:R:D117	R:R:D121	9.31	1	No	Yes	6	5	1	1
R:R:I180	R:R:N118	4.25	1	Yes	No	5	4	1	2
R:R:I180	R:R:V122	4.61	1	Yes	No	5	5	1	2
R:R:M128	R:R:T124	4.52	1	Yes	Yes	5	5	1	1
R:R:C125	R:R:I180	6.55	0	No	Yes	4	5	2	1
R:R:M128	R:R:W254	5.82	1	Yes	Yes	5	7	1	2
R:R:I287	R:R:M128	4.37	1	Yes	Yes	7	5	2	1
R:R:L189	R:R:L261	4.15	1	Yes	No	4	5	1	1
R:R:I264	R:R:L189	4.28	0	No	Yes	4	4	2	1
R:R:F258	R:R:W254	6.01	0	Yes	Yes	5	7	2	2
R:R:I287	R:R:W254	8.22	1	Yes	Yes	7	7	2	2
R:R:F257	R:R:F258	10.72	0	Yes	Yes	5	5	1	2
R:R:F257	R:R:L261	13.4	0	Yes	No	5	5	1	1
R:R:F257	R:R:F280	6.43	0	Yes	Yes	5	4	1	1
R:R:F257	R:R:I287	6.28	0	Yes	Yes	5	7	1	2
R:R:H260	R:R:I264	5.3	0	Yes	No	4	4	2	2
R:R:F277	R:R:H260	18.1	0	Yes	Yes	3	4	1	2
R:R:F280	R:R:H260	13.58	0	Yes	Yes	4	4	1	2
R:R:C267	R:R:C273	7.28	0	No	No	3	4	2	2
R:R:C273	R:R:F277	6.98	0	No	Yes	4	3	2	1
R:R:F277	R:R:G274	6.02	0	Yes	No	3	2	1	2
R:R:F280	R:R:L284	9.74	0	Yes	No	4	4	1	2
R:R:A108	R:R:L113	3.15	0	No	Yes	1	6	2	1
R:R:L116	R:R:V97	2.98	0	No	No	3	4	2	1
R:R:L189	R:R:V265	2.98	1	Yes	No	4	4	1	2
R:R:D121	R:R:I120	2.8	1	Yes	No	5	5	1	2
L:L:?4	R:R:V97	2.79	0	Yes	No	0	4	0	1
R:R:L101	R:R:L113	2.77	0	No	Yes	3	6	2	1
R:R:C267	R:R:P268	1.88	0	No	No	3	3	2	1
L:L:V13	R:R:P268	1.77	0	No	No	0	3	0	1
R:R:D42	R:R:G43	1.68	1	Yes	No	3	5	1	2
R:R:L113	R:R:L116	1.38	0	Yes	No	6	3	1	2
L:L:Y2	R:R:L113	1.17	0	No	Yes	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F4H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	252
Number of Links	280
Number of Hubs	37
Number of Links mediated by Hubs	137
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	57593
Length Of Smallest Path	3
Average Path Length	12.8081
Length of Longest Path	28
Minimum Path Strength	1.275
Average Path Strength	6.85369
Maximum Path Strength	19.29
Minimum Path Correlation	0.7
Average Path Correlation	0.930352
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	52.9022
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9863
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • phosphorus-oxygen lyase activity • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • D1 dopamine receptor binding • molecular function activator activity • enzyme activator activity • cyclase activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • protein localization • positive regulation of protein localization to cell periphery • regulation of localization • protein localization to cell periphery • cellular localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • localization • regulation of cellular localization • regulation of protein localization to cell cortex • cellular macromolecule localization • macromolecule localization • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to nitrogen compound • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • adenylate cyclase-activating G protein-coupled receptor signaling pathway • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of multicellular organismal process • establishment of protein localization • nitrogen compound transport • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • regulation of hormone secretion • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • midbody • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • Golgi apparatus subcompartment • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • tetrapyrrole binding • heme binding • electron transfer activity • transition metal ion binding • iron ion binding • melanocyte-stimulating hormone receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • melanocortin receptor activity • hormone binding • ubiquitin protein ligase binding • ubiquitin-like protein ligase binding • electron transport chain • generation of precursor metabolites and energy • regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • cytokine production • regulation of cytokine production • negative regulation of cellular process • negative regulation of macromolecule metabolic process • negative regulation of metabolic process • tumor necrosis factor superfamily cytokine production • negative regulation of cytokine production • regulation of macromolecule metabolic process • gene expression • macromolecule biosynthetic process • tumor necrosis factor production • regulation of gene expression • negative regulation of gene expression • regulation of tumor necrosis factor superfamily cytokine production • negative regulation of biosynthetic process • negative regulation of macromolecule biosynthetic process • negative regulation of tumor necrosis factor superfamily cytokine production • regulation of macromolecule biosynthetic process • macromolecule metabolic process • negative regulation of multicellular organismal process • pigment metabolic process • pigment biosynthetic process • melanin metabolic process • secondary metabolic process • secondary metabolite biosynthetic process • phenol-containing compound metabolic process • phenol-containing compound biosynthetic process • melanin biosynthetic process • response to light stimulus • response to radiation • response to abiotic stimulus • response to UV • UV protection • pigmentation • positive regulation of feeding behavior • feeding behavior • regulation of behavior • behavior • positive regulation of behavior • regulation of feeding behavior • cellular response to environmental stimulus • nucleobase-containing compound metabolic process • cellular response to light stimulus • DNA repair • DNA metabolic process • cellular response to radiation • nucleic acid metabolic process • UV-damage excision repair • DNA damage response • cellular response to abiotic stimulus • cellular response to UV • sensory perception of pain • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • positive regulation of cAMP/PKA signal transduction • positive regulation of response to stimulus • cAMP/PKA signal transduction • regulation of intracellular signal transduction • positive regulation of intracellular signal transduction • regulation of cAMP/PKA signal transduction • positive regulation of signaling • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of transcription by RNA polymerase II • positive regulation of nucleobase-containing compound metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • regulation of DNA-templated transcription • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	6991974
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	6919011
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>7F4H_nogp_Chain_R L E V S I S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T L K E V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	10.1038/s41422-021-00557-y
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	10.1038/s41422-021-00557-y

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