psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y2	R:R:R109	8.23	No	No	0	0	3
2	L:L:?4	L:L:E5	4.97	Yes	No	0	0	0
3	L:L:?4	R:R:I98	8.03	Yes	No	0	0	3
4	L:L:?4	R:R:D117	12.73	Yes	No	0	0	6
5	L:L:E5	L:L:K11	5.4	No	No	0	0	0
6	L:L:H6	R:R:D42	5.04	Yes	Yes	1	0	3
7	L:L:H6	R:R:F45	18.1	Yes	No	0	0	6
8	L:L:H6	R:R:E94	7.39	Yes	No	1	0	4
9	L:L:H6	R:R:T95	6.85	Yes	No	1	0	5
10	L:L:H6	R:R:I98	5.3	Yes	No	0	0	3
11	L:L:?7	L:L:R8	11.32	Yes	Yes	1	0	0
12	L:L:?7	L:L:W9	6.76	Yes	Yes	1	0	0
13	L:L:?7	R:R:E94	12.35	Yes	No	1	0	4
14	L:L:?7	R:R:D121	18.4	Yes	Yes	1	0	5
15	L:L:?7	R:R:T124	11.24	Yes	Yes	1	0	5
16	L:L:?7	R:R:M128	4.79	Yes	Yes	1	0	5
17	L:L:?7	R:R:I180	4.84	Yes	Yes	1	0	5
18	L:L:?7	R:R:F257	6.19	Yes	Yes	0	0	5
19	L:L:R8	L:L:W9	7	Yes	Yes	1	0	0
20	L:L:R8	R:R:D117	5.96	Yes	No	1	0	6
21	L:L:R8	R:R:D121	14.29	Yes	Yes	1	0	5
22	L:L:R8	R:R:I180	5.01	Yes	Yes	1	0	5
23	L:L:R8	R:R:Y183	23.66	Yes	No	1	0	3
24	L:L:W9	R:R:Y183	5.79	Yes	No	1	0	3
25	L:L:W9	R:R:L189	10.25	Yes	Yes	1	0	4
26	L:L:W9	R:R:L261	6.83	Yes	No	1	0	5
27	L:L:G10	R:R:F280	10.54	No	Yes	0	0	4
28	L:L:P12	R:R:F277	8.67	No	Yes	0	0	3
29	R:R:E37	R:R:S39	4.31	No	No	0	2	2
30	R:R:L282	R:R:V38	13.41	No	No	0	3	5
31	R:R:I40	R:R:L44	8.56	No	No	0	6	5
32	R:R:D42	R:R:T95	5.78	Yes	No	1	3	5
33	R:R:D42	R:R:L99	6.79	Yes	No	0	3	4
34	R:R:L44	R:R:L48	5.54	No	No	0	5	6
35	R:R:F45	R:R:N91	6.04	No	Yes	0	6	7
36	R:R:F45	R:R:L284	6.09	No	No	0	6	4
37	R:R:L46	R:R:L50	5.54	No	No	1	5	5
38	R:R:L46	R:R:V92	4.47	No	No	1	5	6
39	R:R:L46	R:R:T95	4.42	No	No	1	5	5
40	R:R:L50	R:R:V92	5.96	No	No	1	5	6
41	R:R:S52	R:R:S88	4.89	No	No	0	8	9
42	R:R:I288	R:R:S52	4.64	No	No	0	6	8
43	R:R:I292	R:R:S52	4.64	No	No	0	5	8
44	R:R:L53	R:R:L85	4.15	No	No	0	5	7
45	R:R:L53	R:R:S88	6.01	No	No	0	5	9
46	R:R:A81	R:R:N56	4.69	No	No	0	9	9
47	R:R:D84	R:R:N56	8.08	Yes	No	0	9	9
48	R:R:N56	R:R:P295	6.52	No	No	0	9	9
49	R:R:L309	R:R:L58	4.15	No	No	0	6	7
50	R:R:A299	R:R:V59	5.09	No	No	0	8	9
51	R:R:C78	R:R:V60	5.12	No	No	0	6	7
52	R:R:T308	R:R:T62	6.28	No	No	0	8	8
53	R:R:I63	R:R:L69	7.14	No	Yes	0	8	8
54	R:R:C78	R:R:I63	9.82	No	No	0	6	8
55	R:R:K65	R:R:V312	4.55	No	No	0	5	7
56	R:R:N66	R:R:N68	10.9	No	No	0	8	7
57	R:R:L69	R:R:N66	9.61	Yes	No	0	8	8
58	R:R:N66	R:R:T308	10.24	No	No	0	8	8
59	R:R:H70	R:R:R67	6.77	No	No	0	8	7
60	R:R:L69	R:R:Y74	10.55	Yes	Yes	0	8	8
61	R:R:L305	R:R:L69	6.92	No	Yes	0	8	8
62	R:R:S71	R:R:Y74	6.36	No	Yes	0	7	8
63	R:R:L158	R:R:P72	6.57	No	No	0	3	7
64	R:R:M73	R:R:Y74	13.17	No	Yes	0	8	8
65	R:R:D141	R:R:M73	4.16	No	No	0	9	8
66	R:R:S302	R:R:Y74	7.63	No	Yes	0	8	8
67	R:R:C75	R:R:R162	5.57	No	No	0	4	1
68	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
69	R:R:D141	R:R:F76	5.97	No	Yes	0	9	7
70	R:R:A161	R:R:F76	4.16	No	Yes	0	6	7
71	R:R:C79	R:R:F134	11.17	No	Yes	2	9	8
72	R:R:C79	R:R:V165	8.54	No	No	2	9	7
73	R:R:D84	R:R:L80	5.43	Yes	No	0	9	9
74	R:R:L135	R:R:L80	5.54	Yes	No	0	8	9
75	R:R:I138	R:R:L80	4.28	No	No	0	9	9
76	R:R:L82	R:R:W169	6.83	No	Yes	0	6	9
77	R:R:S130	R:R:S83	4.89	No	No	2	7	8
78	R:R:F134	R:R:S83	7.93	Yes	No	2	8	8
79	R:R:S83	R:R:W169	7.41	No	Yes	2	8	9
80	R:R:D84	R:R:S131	7.36	Yes	No	0	9	9
81	R:R:A291	R:R:D84	4.63	No	Yes	0	9	9
82	R:R:S127	R:R:V87	6.46	No	No	0	7	8
83	R:R:I123	R:R:S90	6.19	No	No	0	4	5
84	R:R:S90	R:R:T124	6.4	No	Yes	0	5	5
85	R:R:N91	R:R:T124	8.77	Yes	Yes	0	7	5
86	R:R:I288	R:R:N91	5.66	No	Yes	0	6	7
87	R:R:I120	R:R:L93	5.71	No	No	0	5	8
88	R:R:D121	R:R:E94	6.5	Yes	No	1	5	4
89	R:R:E102	R:R:L101	5.3	No	No	0	3	3
90	R:R:L101	R:R:L106	4.15	No	No	0	3	3
91	R:R:A110	R:R:R109	6.91	No	No	0	3	3
92	R:R:Q114	R:R:Q115	7.68	No	No	0	2	1
93	R:R:D117	R:R:D121	9.31	No	Yes	1	6	5
94	R:R:I180	R:R:N118	4.25	Yes	No	0	5	4
95	R:R:I180	R:R:V122	4.61	Yes	No	0	5	5
96	R:R:M128	R:R:T124	4.52	Yes	Yes	1	5	5
97	R:R:C125	R:R:S176	6.89	No	No	0	4	7
98	R:R:C125	R:R:I180	6.55	No	Yes	0	4	5
99	R:R:S126	R:R:S172	4.89	No	No	0	5	7
100	R:R:S126	R:R:V173	4.85	No	No	0	5	3
101	R:R:S126	R:R:S176	4.89	No	No	0	5	7
102	R:R:M128	R:R:W254	5.82	Yes	Yes	1	5	7
103	R:R:I287	R:R:M128	4.37	Yes	Yes	1	7	5
104	R:R:L129	R:R:S172	6.01	No	No	0	5	7
105	R:R:L129	R:R:S176	4.5	No	No	0	5	7
106	R:R:F195	R:R:L129	4.87	No	No	0	4	5
107	R:R:S130	R:R:W169	11.12	No	Yes	2	7	9
108	R:R:S130	R:R:S172	6.52	No	No	0	7	7
109	R:R:S131	R:R:W254	4.94	No	Yes	0	9	7
110	R:R:F195	R:R:L132	6.09	No	No	0	4	7
111	R:R:L132	R:R:W254	15.94	No	Yes	0	7	7
112	R:R:C133	R:R:I168	8.18	No	No	0	4	6
113	R:R:F134	R:R:V165	5.24	Yes	No	2	8	7
114	R:R:F134	R:R:I168	11.3	Yes	No	0	8	6
115	R:R:F134	R:R:W169	12.03	Yes	Yes	2	8	9
116	R:R:F250	R:R:L135	6.09	Yes	Yes	1	8	8
117	R:R:L135	R:R:W254	4.56	Yes	Yes	1	8	7
118	R:R:L135	R:R:Y298	4.69	Yes	Yes	0	8	9
119	R:R:I138	R:R:Y298	4.84	No	Yes	0	9	9
120	R:R:A139	R:R:Y207	5.34	No	Yes	0	9	8
121	R:R:D141	R:R:Y152	10.34	No	Yes	0	9	8
122	R:R:R142	R:R:Y207	10.29	No	Yes	3	9	8
123	R:R:M210	R:R:R142	4.96	No	No	3	9	9
124	R:R:H301	R:R:R142	6.77	No	No	0	7	9
125	R:R:F147	R:R:Y143	16.5	Yes	No	4	6	7
126	R:R:L206	R:R:Y143	12.89	No	No	0	5	7
127	R:R:H209	R:R:Y143	7.62	No	No	4	6	7
128	R:R:I144	R:R:I155	5.89	No	No	0	6	5
129	R:R:I144	R:R:V156	4.61	No	No	0	6	7
130	R:R:S145	R:R:Y152	7.63	No	Yes	0	9	8
131	R:R:F147	R:R:I146	8.79	Yes	No	0	6	8
132	R:R:I146	R:R:M210	5.83	No	No	0	8	9
133	R:R:F147	R:R:H209	22.63	Yes	No	4	6	6
134	R:R:F147	R:R:R213	5.34	Yes	No	0	6	6
135	R:R:R151	R:R:Y148	9.26	No	No	0	6	6
136	R:R:H153	R:R:Y152	8.71	No	Yes	0	5	8
137	R:R:V156	R:R:Y152	7.57	No	Yes	0	7	8
138	R:R:P159	R:R:T157	6.99	No	No	0	4	8
139	R:R:F175	R:R:F179	4.29	No	Yes	0	4	5
140	R:R:F179	R:R:L178	4.87	Yes	No	0	5	5
141	R:R:F179	R:R:V188	11.8	Yes	No	0	5	4
142	R:R:C191	R:R:F179	5.59	No	Yes	0	4	5
143	R:R:A187	R:R:H185	5.85	No	No	0	4	4
144	R:R:L189	R:R:L261	4.15	Yes	No	1	4	5
145	R:R:I264	R:R:L189	4.28	No	Yes	0	4	4
146	R:R:F258	R:R:L192	6.09	Yes	No	0	5	5
147	R:R:T262	R:R:V193	7.93	No	No	0	4	4
148	R:R:F195	R:R:M199	8.71	No	No	0	4	7
149	R:R:F196	R:R:F250	6.43	Yes	Yes	0	7	8
150	R:R:F196	R:R:G255	4.52	Yes	No	0	7	5
151	R:R:F196	R:R:F258	27.86	Yes	Yes	0	7	5
152	R:R:F250	R:R:L200	4.87	Yes	No	0	8	5
153	R:R:F251	R:R:L200	4.87	No	No	0	6	5
154	R:R:L202	R:R:L206	6.92	No	No	0	5	5
155	R:R:M203	R:R:Y207	5.99	No	Yes	0	8	8
156	R:R:L247	R:R:M203	4.24	No	No	0	7	8
157	R:R:F250	R:R:M203	8.71	Yes	No	0	8	8
158	R:R:M210	R:R:Y207	4.79	No	Yes	3	9	8
159	R:R:L246	R:R:Y207	8.21	No	Yes	0	8	8
160	R:R:L211	R:R:L243	4.15	Yes	No	0	6	8
161	R:R:Q216	R:R:R213	8.18	No	No	0	4	6
162	R:R:H217	R:R:R213	15.8	No	No	0	8	6
163	R:R:L243	R:R:L247	5.54	No	No	0	8	7
164	R:R:L246	R:R:Y298	5.86	No	Yes	0	8	9
165	R:R:I249	R:R:I293	4.42	No	No	0	6	5
166	R:R:I249	R:R:I297	4.42	No	No	0	6	8
167	R:R:F250	R:R:W254	8.02	Yes	Yes	1	8	7
168	R:R:C253	R:R:N290	6.3	No	Yes	0	8	9
169	R:R:F258	R:R:W254	6.01	Yes	Yes	0	5	7
170	R:R:I287	R:R:W254	8.22	Yes	Yes	1	7	7
171	R:R:N290	R:R:W254	16.95	Yes	Yes	1	9	7
172	R:R:F283	R:R:P256	10.11	Yes	No	0	5	9
173	R:R:F257	R:R:F258	10.72	Yes	Yes	0	5	5
174	R:R:F257	R:R:L261	13.4	Yes	No	0	5	5
175	R:R:F257	R:R:F280	6.43	Yes	Yes	0	5	4
176	R:R:F257	R:R:I287	6.28	Yes	Yes	0	5	7
177	R:R:H260	R:R:I264	5.3	Yes	No	0	4	4
178	R:R:F277	R:R:H260	18.1	Yes	Yes	0	3	4
179	R:R:F280	R:R:H260	13.58	Yes	Yes	0	4	4
180	R:R:F283	R:R:H260	6.79	Yes	Yes	0	5	4
181	R:R:C273	R:R:L263	6.35	No	No	0	4	4
182	R:R:I276	R:R:L263	5.71	No	No	0	4	4
183	R:R:C267	R:R:H270	4.42	No	No	0	3	4
184	R:R:C267	R:R:C273	7.28	No	No	0	3	4
185	R:R:H270	R:R:P271	13.73	No	No	0	4	3
186	R:R:H270	R:R:T272	10.95	No	No	0	4	4
187	R:R:C273	R:R:F277	6.98	No	Yes	0	4	3
188	R:R:F277	R:R:G274	6.02	Yes	No	0	3	2
189	R:R:F283	R:R:N279	4.83	Yes	No	0	5	4
190	R:R:F280	R:R:L284	9.74	Yes	No	0	4	4
191	R:R:F283	R:R:L282	4.87	Yes	No	0	5	3
192	R:R:L282	R:R:L286	6.92	No	No	0	3	7
193	R:R:I287	R:R:N290	4.25	Yes	Yes	1	7	9
194	R:R:D294	R:R:N290	6.73	No	Yes	0	9	9
195	R:R:D294	R:R:Y298	4.6	No	Yes	0	9	9
196	R:R:I297	R:R:Y298	12.09	No	Yes	0	8	9
197	R:R:F300	R:R:L309	7.31	No	No	0	5	6
198	R:R:L305	R:R:S302	4.5	No	No	0	8	8
199	R:R:Q303	R:R:R306	17.52	No	No	5	6	9
200	R:R:Q303	R:R:R307	5.84	No	No	5	6	6
201	R:R:R306	R:R:R307	4.26	No	No	5	9	6
202	R:R:N118	R:R:Q114	3.96	No	No	0	4	2
203	R:R:R160	R:R:T157	3.88	No	No	0	7	8
204	R:R:A161	R:R:P72	3.74	No	No	0	6	7
205	R:R:G89	R:R:S88	3.71	No	No	0	3	9
206	R:R:F179	R:R:L192	3.65	Yes	No	0	5	5
207	R:R:G239	R:R:T242	3.64	No	No	0	8	9
208	R:R:I155	R:R:Y148	3.63	No	No	0	5	6
209	R:R:G49	R:R:I288	3.53	No	No	0	6	6
210	R:R:P295	R:R:V59	3.53	No	No	0	9	9
211	R:R:E304	R:R:Y74	3.37	No	Yes	0	7	8
212	R:R:A285	R:R:I40	3.25	No	No	0	5	6
213	R:R:V186	R:R:V265	3.21	No	No	0	1	4
214	R:R:T177	R:R:V122	3.17	No	No	0	4	5
215	R:R:C215	R:R:L211	3.17	No	Yes	0	5	6
216	R:R:A105	R:R:L100	3.15	No	No	0	4	4
217	R:R:A108	R:R:L113	3.15	No	Yes	0	1	6
218	R:R:A204	R:R:L247	3.15	No	No	0	4	7
219	R:R:A299	R:R:L305	3.15	No	No	0	8	8
220	R:R:I292	R:R:V51	3.07	No	No	0	5	5
221	R:R:I144	R:R:V140	3.07	No	No	0	6	6
222	R:R:L86	R:R:S127	3	No	No	0	7	7
223	R:R:G220	R:R:R223	3	No	No	0	5	3
224	R:R:L58	R:R:V54	2.98	No	No	0	7	4
225	R:R:L116	R:R:V97	2.98	No	No	0	3	4
226	R:R:L189	R:R:V265	2.98	Yes	No	0	4	4
227	R:R:L197	R:R:V193	2.98	No	No	0	4	4
228	R:R:L243	R:R:V208	2.98	No	No	0	8	4
229	R:R:N91	R:R:V87	2.96	Yes	No	0	7	8
230	R:R:L266	R:R:T262	2.95	No	No	0	3	4
231	R:R:I63	R:R:I77	2.94	No	No	0	8	7
232	R:R:I138	R:R:I77	2.94	No	No	0	9	7
233	R:R:I245	R:R:I297	2.94	No	No	0	7	8
234	R:R:D121	R:R:I120	2.8	Yes	No	0	5	5
235	L:L:?4	R:R:V97	2.79	Yes	No	0	0	4
236	R:R:L101	R:R:L113	2.77	No	Yes	0	3	6
237	R:R:A171	R:R:F175	2.77	No	No	0	3	4
238	R:R:L259	R:R:L263	2.77	No	No	0	6	4
239	R:R:F300	R:R:V59	2.62	No	No	0	5	9
240	R:R:F196	R:R:L197	2.44	Yes	No	0	7	4
241	R:R:L178	R:R:Y182	2.34	No	No	0	5	4
242	R:R:F300	R:R:R306	2.14	No	No	0	5	9
243	R:R:A139	R:R:G136	1.95	No	No	0	9	7
244	R:R:C267	R:R:P268	1.88	No	No	0	3	3
245	R:R:C75	R:R:C79	1.82	No	No	0	4	9
246	R:R:C253	R:R:C289	1.82	No	No	0	8	4
247	L:L:P12	L:L:V13	1.77	No	No	0	0	0
248	L:L:V13	R:R:P268	1.77	No	No	0	0	3
249	R:R:G239	R:R:K238	1.74	No	No	0	8	8
250	R:R:G274	R:R:K278	1.74	No	No	0	2	2
251	R:R:G49	R:R:L48	1.71	No	No	0	6	6
252	R:R:G239	R:R:L211	1.71	No	Yes	0	8	6
253	R:R:G248	R:R:L252	1.71	No	No	0	6	4
254	R:R:A108	R:R:V112	1.7	No	No	0	1	3
255	R:R:D42	R:R:G43	1.68	Yes	No	0	3	5
256	R:R:L158	R:R:P159	1.64	No	No	0	3	4
257	R:R:V170	R:R:V174	1.6	No	No	0	4	4
258	R:R:V201	R:R:V205	1.6	No	No	0	4	4
259	R:R:A57	R:R:L85	1.58	No	No	0	5	7
260	R:R:A214	R:R:L211	1.58	No	Yes	0	8	6
261	R:R:A240	R:R:L211	1.58	No	Yes	0	7	6
262	R:R:A240	R:R:L237	1.58	No	No	0	7	5
263	R:R:E55	R:R:P295	1.57	No	No	0	8	9
264	R:R:C275	R:R:N279	1.57	No	No	0	3	4
265	R:R:I245	R:R:V241	1.54	No	No	0	7	7
266	R:R:L116	R:R:V119	1.49	No	No	0	3	4
267	R:R:L190	R:R:V194	1.49	No	No	0	4	4
268	R:R:A212	R:R:H209	1.46	No	No	0	3	6
269	R:R:I40	R:R:N281	1.42	No	No	0	6	4
270	L:L:?4	L:L:S3	1.41	Yes	No	0	0	0
271	R:R:E311	R:R:T308	1.41	No	No	0	4	8
272	R:R:A164	R:R:F76	1.39	No	Yes	0	6	7
273	R:R:L113	R:R:L116	1.38	Yes	No	0	6	3
274	R:R:H185	R:R:V188	1.38	No	No	0	4	4
275	R:R:E37	R:R:K278	1.35	No	No	0	2	2
276	R:R:A181	R:R:Y182	1.33	No	No	0	3	4
277	R:R:D184	R:R:H185	1.26	No	No	0	4	4
278	R:R:F251	R:R:L252	1.22	No	No	0	6	4
279	L:L:Y2	R:R:L113	1.17	No	Yes	0	0	6
280	R:R:Q219	R:R:R223	1.17	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?4	5.986	5	0	0
2	L:L:H6	8.536	5	1	0
3	L:L:?7	9.48625	8	1	0
4	L:L:R8	11.2067	6	1	0
5	L:L:W9	7.326	5	1	0
6	R:R:D42	4.8225	4	1	3
7	R:R:L69	8.555	4	0	8
8	R:R:Y74	8.216	5	0	8
9	R:R:F76	3.92	4	0	7
10	R:R:D84	6.375	4	0	9
11	R:R:N91	5.8575	4	0	7
12	R:R:L113	2.1175	4	0	6
13	R:R:D121	10.26	5	1	5
14	R:R:T124	7.7325	4	1	5
15	R:R:M128	4.875	4	1	5
16	R:R:F134	9.534	5	2	8
17	R:R:L135	5.22	4	1	8
18	R:R:F147	13.315	4	4	6
19	R:R:Y152	8.5625	4	0	8
20	R:R:W169	9.3475	4	2	9
21	R:R:F179	6.04	5	0	5
22	R:R:I180	5.052	5	1	5
23	R:R:L189	5.415	4	1	4
24	R:R:F196	10.3125	4	0	7
25	R:R:Y207	6.924	5	3	8
26	R:R:L211	2.438	5	0	6
27	R:R:F250	6.824	5	1	8
28	R:R:W254	8.8075	8	1	7
29	R:R:F257	8.604	5	0	5
30	R:R:F258	12.67	4	0	5
31	R:R:H260	10.9425	4	0	4
32	R:R:F277	9.9425	4	0	3
33	R:R:F280	10.0725	4	0	4
34	R:R:F283	6.65	4	0	5
35	R:R:I287	5.78	4	1	7
36	R:R:N290	8.5575	4	1	9
37	R:R:Y298	6.416	5	0	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?4	R:R:V97	35.0649	2.79	Yes	No	0	0	4
2	R:R:L116	R:R:V97	32.3261	2.98	No	No	0	3	4
3	R:R:L113	R:R:L116	26.571	1.38	Yes	No	0	6	3
4	L:L:?4	R:R:D117	41.9041	12.73	Yes	No	0	0	6
5	L:L:H6	R:R:E94	11.6202	7.39	Yes	No	1	0	4
6	R:R:D117	R:R:D121	18.5693	9.31	No	Yes	1	6	5
7	L:L:?7	L:L:R8	20.3917	11.32	Yes	Yes	1	0	0
8	L:L:R8	R:R:D117	25.9007	5.96	Yes	No	1	0	6
9	L:L:?7	R:R:D121	22.5597	18.4	Yes	Yes	1	0	5
10	L:L:?7	R:R:T124	11.2694	11.24	Yes	Yes	1	0	5
11	L:L:?7	R:R:M128	48.5075	4.79	Yes	Yes	1	0	5
12	L:L:?7	R:R:F257	24.2616	6.19	Yes	Yes	0	0	5
13	R:R:F257	R:R:F280	77.566	6.43	Yes	Yes	0	5	4
14	R:R:F277	R:R:H260	53.142	18.1	Yes	Yes	0	3	4
15	R:R:F280	R:R:H260	76.0578	13.58	Yes	Yes	0	4	4
16	R:R:F277	R:R:G274	12.7723	6.02	Yes	No	0	3	2
17	R:R:F283	R:R:H260	22.2455	6.79	Yes	Yes	0	5	4
18	R:R:I288	R:R:N91	26.9376	5.66	No	Yes	0	6	7
19	R:R:G49	R:R:I288	11.0547	3.53	No	No	0	6	6
20	R:R:I288	R:R:S52	14.6575	4.64	No	No	0	6	8
21	R:R:M128	R:R:W254	70.0356	5.82	Yes	Yes	1	5	7
22	R:R:S131	R:R:W254	22.9891	4.94	No	Yes	0	9	7
23	R:R:D84	R:R:S131	21.9103	7.36	Yes	No	0	9	9
24	R:R:D84	R:R:N56	25.1623	8.08	Yes	No	0	9	9
25	R:R:N56	R:R:P295	22.1984	6.52	No	No	0	9	9
26	R:R:P295	R:R:V59	19.2553	3.53	No	No	0	9	9
27	R:R:F300	R:R:V59	14.9508	2.62	No	No	0	5	9
28	R:R:L135	R:R:W254	86.7773	4.56	Yes	Yes	1	8	7
29	R:R:L135	R:R:L80	49.7801	5.54	Yes	No	0	8	9
30	R:R:I138	R:R:L80	46.2086	4.28	No	No	0	9	9
31	R:R:I138	R:R:I77	100	2.94	No	No	0	9	7
32	R:R:I63	R:R:I77	97.4288	2.94	No	No	0	8	7
33	R:R:L135	R:R:Y298	53.7966	4.69	Yes	Yes	0	8	9
34	R:R:I138	R:R:Y298	60.2011	4.84	No	Yes	0	9	9
35	R:R:I63	R:R:L69	89.7151	7.14	No	Yes	0	8	8
36	R:R:L69	R:R:N66	15.0503	9.61	Yes	No	0	8	8
37	R:R:L69	R:R:Y74	69.4229	10.55	Yes	Yes	0	8	8
38	R:R:M73	R:R:Y74	59.7612	13.17	No	Yes	0	8	8
39	R:R:D141	R:R:M73	56.8601	4.16	No	No	0	9	8
40	R:R:D141	R:R:F76	27.2675	5.97	No	Yes	0	9	7
41	R:R:A161	R:R:F76	18.4384	4.16	No	Yes	0	6	7
42	R:R:A161	R:R:P72	15.3907	3.74	No	No	0	6	7
43	R:R:L158	R:R:P72	12.3324	6.57	No	No	0	3	7
44	R:R:C125	R:R:I180	26.0369	6.55	No	Yes	0	4	5
45	R:R:C125	R:R:S176	24.8115	6.89	No	No	0	4	7
46	R:R:S126	R:R:S176	14.2124	4.89	No	No	0	5	7
47	R:R:S126	R:R:S172	13.0184	4.89	No	No	0	5	7
48	R:R:S130	R:R:S172	45.1456	6.52	No	No	0	7	7
49	R:R:S130	R:R:S83	20.1037	4.89	No	No	2	7	8
50	R:R:F134	R:R:S83	17.6267	7.93	Yes	No	2	8	8
51	R:R:C79	R:R:F134	15.1707	11.17	No	Yes	2	9	8
52	R:R:C75	R:R:C79	10.133	1.82	No	No	0	4	9
53	R:R:L129	R:R:S176	14.5633	4.5	No	No	0	5	7
54	R:R:L129	R:R:S172	38.0917	6.01	No	No	0	5	7
55	R:R:S130	R:R:W169	22.6173	11.12	No	Yes	2	7	9
56	R:R:F134	R:R:W169	17.6634	12.03	Yes	Yes	2	8	9
57	R:R:F257	R:R:I287	39.4533	6.28	Yes	Yes	0	5	7
58	R:R:L132	R:R:W254	35.5205	15.94	No	Yes	0	7	7
59	R:R:F195	R:R:L132	33.9809	6.09	No	No	0	4	7
60	R:R:F195	R:R:L129	31.195	4.87	No	No	0	4	5
61	R:R:F134	R:R:I168	10.133	11.3	Yes	No	0	8	6
62	R:R:F250	R:R:W254	40.9615	8.02	Yes	Yes	1	8	7
63	R:R:F250	R:R:M203	49.9057	8.71	Yes	No	0	8	8
64	R:R:M203	R:R:Y207	28.3934	5.99	No	Yes	0	8	8
65	R:R:D141	R:R:Y152	27.5189	10.34	No	Yes	0	9	8
66	R:R:M210	R:R:Y207	22.2769	4.79	No	Yes	3	9	8
67	R:R:I146	R:R:M210	20.3812	5.83	No	No	0	8	9
68	R:R:F147	R:R:I146	18.5065	8.79	Yes	No	0	6	8
69	R:R:V156	R:R:Y152	18.4384	7.57	No	Yes	0	7	8
70	R:R:I144	R:R:V156	15.3907	4.61	No	No	0	6	7
71	R:R:F257	R:R:F258	46.9418	10.72	Yes	Yes	0	5	5
72	R:R:F258	R:R:L192	22.2246	6.09	Yes	No	0	5	5
73	R:R:F179	R:R:L192	20.4179	3.65	Yes	No	0	5	5
74	R:R:F196	R:R:F258	15.0765	27.86	Yes	Yes	0	7	5
75	R:R:L247	R:R:M203	27.5817	4.24	No	No	0	7	8
76	R:R:L246	R:R:Y298	11.3008	5.86	No	Yes	0	8	9
77	R:R:L243	R:R:L247	23.0886	5.54	No	No	0	8	7
78	R:R:L211	R:R:L243	18.5536	4.15	Yes	No	0	6	8
79	R:R:I287	R:R:N290	12.0706	4.25	Yes	Yes	1	7	9
80	R:R:C273	R:R:F277	28.43	6.98	No	Yes	0	4	3
81	R:R:C267	R:R:C273	15.9039	7.28	No	No	0	3	4
82	R:R:D294	R:R:N290	11.0756	6.73	No	Yes	0	9	9
83	R:R:N91	R:R:T124	29.514	8.77	Yes	Yes	0	7	5
84	L:L:?7	R:R:E94	12.5681	12.35	Yes	No	1	0	4
85	R:R:F257	R:R:L261	11.1332	13.4	Yes	No	0	5	5
86	L:L:?7	R:R:I180	25.4137	4.84	Yes	Yes	1	0	5
87	R:R:M128	R:R:T124	23.2352	4.52	Yes	Yes	1	5	5
88	R:R:F258	R:R:W254	43.9254	6.01	Yes	Yes	0	5	7
89	R:R:F196	R:R:F250	15.0136	6.43	Yes	Yes	0	7	8
90	R:R:I287	R:R:W254	29.5769	8.22	Yes	Yes	1	7	7
91	R:R:F250	R:R:L135	13.7097	6.09	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y2	R:R:R109	8.23	0	No	No	0	3	0	1
L:L:?4	R:R:I98	8.03	0	Yes	No	0	3	0	1
L:L:?4	R:R:D117	12.73	0	Yes	No	0	6	0	1
L:L:H6	R:R:D42	5.04	1	Yes	Yes	0	3	0	1
L:L:H6	R:R:F45	18.1	1	Yes	No	0	6	0	1
L:L:H6	R:R:E94	7.39	1	Yes	No	0	4	0	1
L:L:H6	R:R:T95	6.85	1	Yes	No	0	5	0	1
L:L:H6	R:R:I98	5.3	1	Yes	No	0	3	0	1
L:L:?7	R:R:E94	12.35	1	Yes	No	0	4	0	1
L:L:?7	R:R:D121	18.4	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:T124	11.24	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:M128	4.79	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:I180	4.84	1	Yes	Yes	0	5	0	1
L:L:?7	R:R:F257	6.19	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:D117	5.96	1	Yes	No	0	6	0	1
L:L:R8	R:R:D121	14.29	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:I180	5.01	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:Y183	23.66	1	Yes	No	0	3	0	1
L:L:W9	R:R:Y183	5.79	1	Yes	No	0	3	0	1
L:L:W9	R:R:L189	10.25	1	Yes	Yes	0	4	0	1
L:L:W9	R:R:L261	6.83	1	Yes	No	0	5	0	1
L:L:G10	R:R:F280	10.54	0	No	Yes	0	4	0	1
L:L:P12	R:R:F277	8.67	0	No	Yes	0	3	0	1
R:R:D42	R:R:T95	5.78	1	Yes	No	3	5	1	1
R:R:D42	R:R:L99	6.79	1	Yes	No	3	4	1	2
R:R:F45	R:R:N91	6.04	0	No	Yes	6	7	1	2
R:R:F45	R:R:L284	6.09	0	No	No	6	4	1	2
R:R:L46	R:R:T95	4.42	1	No	No	5	5	2	1
R:R:S90	R:R:T124	6.4	0	No	Yes	5	5	2	1
R:R:N91	R:R:T124	8.77	0	Yes	Yes	7	5	2	1
R:R:D121	R:R:E94	6.5	1	Yes	No	5	4	1	1
R:R:A110	R:R:R109	6.91	0	No	No	3	3	2	1
R:R:D117	R:R:D121	9.31	1	No	Yes	6	5	1	1
R:R:I180	R:R:N118	4.25	1	Yes	No	5	4	1	2
R:R:I180	R:R:V122	4.61	1	Yes	No	5	5	1	2
R:R:M128	R:R:T124	4.52	1	Yes	Yes	5	5	1	1
R:R:C125	R:R:I180	6.55	0	No	Yes	4	5	2	1
R:R:M128	R:R:W254	5.82	1	Yes	Yes	5	7	1	2
R:R:I287	R:R:M128	4.37	1	Yes	Yes	7	5	2	1
R:R:L189	R:R:L261	4.15	1	Yes	No	4	5	1	1
R:R:I264	R:R:L189	4.28	0	No	Yes	4	4	2	1
R:R:F258	R:R:W254	6.01	0	Yes	Yes	5	7	2	2
R:R:I287	R:R:W254	8.22	1	Yes	Yes	7	7	2	2
R:R:F257	R:R:F258	10.72	0	Yes	Yes	5	5	1	2
R:R:F257	R:R:L261	13.4	0	Yes	No	5	5	1	1
R:R:F257	R:R:F280	6.43	0	Yes	Yes	5	4	1	1
R:R:F257	R:R:I287	6.28	0	Yes	Yes	5	7	1	2
R:R:H260	R:R:I264	5.3	0	Yes	No	4	4	2	2
R:R:F277	R:R:H260	18.1	0	Yes	Yes	3	4	1	2
R:R:F280	R:R:H260	13.58	0	Yes	Yes	4	4	1	2
R:R:C267	R:R:C273	7.28	0	No	No	3	4	2	2
R:R:C273	R:R:F277	6.98	0	No	Yes	4	3	2	1
R:R:F277	R:R:G274	6.02	0	Yes	No	3	2	1	2
R:R:F280	R:R:L284	9.74	0	Yes	No	4	4	1	2
R:R:A108	R:R:L113	3.15	0	No	Yes	1	6	2	1
R:R:L116	R:R:V97	2.98	0	No	No	3	4	2	1
R:R:L189	R:R:V265	2.98	1	Yes	No	4	4	1	2
R:R:D121	R:R:I120	2.8	1	Yes	No	5	5	1	2
L:L:?4	R:R:V97	2.79	0	Yes	No	0	4	0	1
R:R:L101	R:R:L113	2.77	0	No	Yes	3	6	2	1
R:R:C267	R:R:P268	1.88	0	No	No	3	3	2	1
L:L:V13	R:R:P268	1.77	0	No	No	0	3	0	1
R:R:D42	R:R:G43	1.68	1	Yes	No	3	5	1	2
R:R:L113	R:R:L116	1.38	0	Yes	No	6	3	1	2
L:L:Y2	R:R:L113	1.17	0	No	Yes	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F4H_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.14
Number of Linked Nodes	252
Number of Links	280
Number of Hubs	37
Number of Links mediated by Hubs	137
Number of Communities	5
Number of Nodes involved in Communities	38
Number of Links involved in Communities	52

Path Summary
Number Of Nodes in MetaPath	92
Number Of Links MetaPath	91
Number of Shortest Paths	57593
Length Of Smallest Path	3
Average Path Length	12.8081
Length of Longest Path	28
Minimum Path Strength	1.275
Average Path Strength	6.85369
Maximum Path Strength	19.29
Minimum Path Correlation	0.7
Average Path Correlation	0.930363
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	52.9036
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.9863
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	21236
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	DPN
PDB Residues	L:L:?7
Environment Details	Open EMBL-EBI Page
Code	DPN
Name	D-Phenylalanine
Synonyms	D-Phenylalanine
Identifier
Formula	C9 H11 N O2
Molecular Weight	165.189
SMILES
PubChem	71567
Formal Charge	0
Total Atoms	23
Total Chiral Atoms	1
Total Bonds	23
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>7F4H_nogp_Chain_R L E V S I S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T L K E V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	9K3P	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3P (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-		2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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