psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Y2	R:R:A110	5.34	No	No	0	0	3
2	L:L:M4	R:R:E94	4.06	Yes	No	0	0	4
3	L:L:M4	R:R:V97	6.09	Yes	No	0	0	4
4	L:L:M4	R:R:I98	5.83	Yes	No	0	0	3
5	L:L:M4	R:R:D117	6.93	Yes	Yes	0	0	6
6	L:L:E5	L:L:R8	12.79	No	Yes	1	0	0
7	L:L:E5	R:R:D117	5.2	No	Yes	1	0	6
8	L:L:H6	R:R:F45	18.1	Yes	Yes	5	0	6
9	L:L:H6	R:R:N91	3.83	Yes	Yes	5	0	7
10	L:L:H6	R:R:T95	9.58	Yes	Yes	5	0	5
11	L:L:H6	R:R:I98	3.98	Yes	No	0	0	3
12	L:L:F7	R:R:D121	9.55	Yes	Yes	0	0	5
13	L:L:F7	R:R:T124	9.08	Yes	No	0	0	5
14	L:L:F7	R:R:M128	6.22	Yes	No	0	0	5
15	L:L:F7	R:R:F257	4.29	Yes	Yes	0	0	5
16	L:L:F7	R:R:F280	4.29	Yes	No	0	0	4
17	L:L:F7	R:R:L284	3.65	Yes	No	0	0	4
18	L:L:R8	L:L:W9	7	Yes	Yes	1	0	0
19	L:L:R8	R:R:D117	13.1	Yes	Yes	1	0	6
20	L:L:R8	R:R:N118	4.82	Yes	No	1	0	4
21	L:L:R8	R:R:D121	14.29	Yes	Yes	1	0	5
22	L:L:R8	R:R:I180	5.01	Yes	Yes	1	0	5
23	L:L:R8	R:R:Y183	5.14	Yes	No	1	0	3
24	L:L:W9	R:R:Y183	3.86	Yes	No	1	0	3
25	L:L:W9	R:R:L189	15.94	Yes	Yes	1	0	4
26	L:L:W9	R:R:L261	5.69	Yes	Yes	1	0	5
27	L:L:G10	R:R:F280	10.54	No	No	0	0	4
28	L:L:K11	L:L:P12	5.02	No	No	0	0	0
29	L:L:P12	R:R:P268	3.9	No	No	0	0	3
30	L:L:P12	R:R:F277	8.67	No	Yes	0	0	3
31	L:L:V13	R:R:Y183	3.79	No	No	0	0	3
32	R:R:E37	R:R:L36	9.28	No	No	0	2	2
33	R:R:C275	R:R:L36	6.35	No	No	0	3	2
34	R:R:I40	R:R:V38	4.61	No	No	0	6	5
35	R:R:K278	R:R:V38	6.07	No	No	0	2	5
36	R:R:N279	R:R:V38	4.43	No	No	0	4	5
37	R:R:L44	R:R:L48	5.54	No	No	0	5	6
38	R:R:F45	R:R:N91	13.29	Yes	Yes	5	6	7
39	R:R:F45	R:R:T95	5.19	Yes	Yes	5	6	5
40	R:R:F45	R:R:N281	8.46	Yes	No	0	6	4
41	R:R:F45	R:R:L284	7.31	Yes	No	5	6	4
42	R:R:A285	R:R:F45	4.16	No	Yes	0	5	6
43	R:R:L46	R:R:L50	4.15	No	No	0	5	5
44	R:R:I292	R:R:V51	6.14	No	No	0	5	5
45	R:R:S52	R:R:S88	4.89	Yes	Yes	7	8	9
46	R:R:I292	R:R:S52	6.19	No	Yes	0	5	8
47	R:R:L53	R:R:L85	4.15	No	No	0	5	7
48	R:R:L53	R:R:S88	7.51	No	Yes	0	5	9
49	R:R:D84	R:R:N56	8.08	Yes	No	0	9	9
50	R:R:N56	R:R:P295	6.52	No	No	0	9	9
51	R:R:P295	R:R:V59	3.53	No	Yes	0	9	9
52	R:R:A299	R:R:V59	5.09	No	Yes	0	8	9
53	R:R:F300	R:R:V59	5.24	No	Yes	0	5	9
54	R:R:I63	R:R:L69	7.14	No	Yes	0	8	8
55	R:R:C78	R:R:I63	9.82	No	No	0	6	8
56	R:R:N66	R:R:N68	12.26	Yes	No	3	8	7
57	R:R:L69	R:R:N66	6.87	Yes	Yes	3	8	8
58	R:R:N66	R:R:T308	11.7	Yes	No	0	8	8
59	R:R:H70	R:R:R67	5.64	No	No	0	8	7
60	R:R:L69	R:R:N68	4.12	Yes	No	3	8	7
61	R:R:E304	R:R:N68	6.57	No	No	3	7	7
62	R:R:L69	R:R:Y74	8.21	Yes	Yes	3	8	8
63	R:R:E304	R:R:L69	6.63	No	Yes	3	7	8
64	R:R:L305	R:R:L69	4.15	Yes	Yes	3	8	8
65	R:R:P72	R:R:S71	3.56	No	No	0	7	7
66	R:R:M73	R:R:S71	6.13	No	No	3	8	7
67	R:R:S71	R:R:Y74	6.36	No	Yes	3	7	8
68	R:R:P72	R:R:V156	3.53	No	No	0	7	7
69	R:R:M73	R:R:Y74	9.58	No	Yes	3	8	8
70	R:R:D141	R:R:M73	4.16	No	No	0	9	8
71	R:R:S302	R:R:Y74	6.36	No	Yes	3	8	8
72	R:R:E304	R:R:Y74	6.73	No	Yes	3	7	8
73	R:R:L305	R:R:Y74	4.69	Yes	Yes	3	8	8
74	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
75	R:R:D141	R:R:F76	5.97	No	Yes	0	9	7
76	R:R:C79	R:R:F134	9.78	No	Yes	4	9	8
77	R:R:C79	R:R:V165	8.54	No	No	4	9	7
78	R:R:D84	R:R:L80	5.43	Yes	Yes	2	9	9
79	R:R:L135	R:R:L80	5.54	No	Yes	2	8	9
80	R:R:I138	R:R:L80	4.28	Yes	Yes	2	9	9
81	R:R:D294	R:R:L80	5.43	No	Yes	2	9	9
82	R:R:L80	R:R:Y298	4.69	Yes	Yes	2	9	9
83	R:R:S130	R:R:S83	4.89	Yes	Yes	4	7	8
84	R:R:S131	R:R:S83	6.52	No	Yes	0	9	8
85	R:R:F134	R:R:S83	5.28	Yes	Yes	4	8	8
86	R:R:S83	R:R:W169	4.94	Yes	Yes	4	8	9
87	R:R:D84	R:R:S131	4.42	Yes	No	0	9	9
88	R:R:A291	R:R:D84	4.63	No	Yes	0	9	9
89	R:R:D294	R:R:D84	10.65	No	Yes	2	9	9
90	R:R:S127	R:R:V87	4.85	No	No	0	7	8
91	R:R:I120	R:R:S90	4.64	Yes	No	0	5	5
92	R:R:I123	R:R:S90	6.19	No	No	0	4	5
93	R:R:S90	R:R:T124	7.99	No	No	0	5	5
94	R:R:N91	R:R:T95	4.39	Yes	Yes	5	7	5
95	R:R:L284	R:R:N91	4.12	No	Yes	5	4	7
96	R:R:I288	R:R:N91	11.33	No	Yes	0	6	7
97	R:R:E94	R:R:I120	9.56	No	Yes	0	4	5
98	R:R:D121	R:R:E94	6.5	Yes	No	0	5	4
99	R:R:L100	R:R:L106	6.92	No	No	0	4	3
100	R:R:L101	R:R:L106	5.54	No	No	0	3	3
101	R:R:L101	R:R:L113	4.15	No	Yes	0	3	6
102	R:R:R109	R:R:V112	7.85	No	No	0	3	3
103	R:R:L113	R:R:Q114	3.99	Yes	No	0	6	2
104	R:R:N118	R:R:Q115	6.6	No	No	0	4	1
105	R:R:I120	R:R:L116	5.71	Yes	No	0	5	3
106	R:R:D117	R:R:D121	9.31	Yes	Yes	1	6	5
107	R:R:I180	R:R:N118	4.25	Yes	No	1	5	4
108	R:R:D121	R:R:I180	4.2	Yes	Yes	1	5	5
109	R:R:I180	R:R:V122	4.61	Yes	No	0	5	5
110	R:R:C125	R:R:S176	6.89	No	No	0	4	7
111	R:R:S126	R:R:S172	6.52	No	No	0	5	7
112	R:R:S126	R:R:V173	4.85	No	No	0	5	3
113	R:R:S126	R:R:S176	4.89	No	No	0	5	7
114	R:R:M128	R:R:W254	5.82	No	Yes	6	5	7
115	R:R:I287	R:R:M128	4.37	No	No	6	7	5
116	R:R:F179	R:R:L129	3.65	Yes	No	0	5	5
117	R:R:F195	R:R:L129	4.87	Yes	No	0	4	5
118	R:R:F134	R:R:S130	5.28	Yes	Yes	4	8	7
119	R:R:S130	R:R:W169	14.83	Yes	Yes	4	7	9
120	R:R:S130	R:R:S172	6.52	Yes	No	4	7	7
121	R:R:F195	R:R:L132	7.31	Yes	No	0	4	7
122	R:R:F196	R:R:L132	3.65	Yes	No	0	7	7
123	R:R:L132	R:R:W254	10.25	No	Yes	0	7	7
124	R:R:C133	R:R:I168	8.18	No	No	0	4	6
125	R:R:C133	R:R:F195	4.19	No	Yes	0	4	4
126	R:R:F134	R:R:V165	5.24	Yes	No	4	8	7
127	R:R:F134	R:R:I168	11.3	Yes	No	0	8	6
128	R:R:F134	R:R:W169	10.02	Yes	Yes	4	8	9
129	R:R:F250	R:R:L135	3.65	Yes	No	0	8	8
130	R:R:L135	R:R:Y298	4.69	No	Yes	2	8	9
131	R:R:I138	R:R:R142	6.26	Yes	Yes	2	9	9
132	R:R:I138	R:R:Y298	6.04	Yes	Yes	2	9	9
133	R:R:A139	R:R:Y207	6.67	No	Yes	0	9	8
134	R:R:D141	R:R:Y152	10.34	No	Yes	0	9	8
135	R:R:R142	R:R:Y207	8.23	Yes	Yes	2	9	8
136	R:R:M210	R:R:R142	3.72	Yes	Yes	2	9	9
137	R:R:R142	R:R:Y298	6.17	Yes	Yes	2	9	9
138	R:R:F147	R:R:Y143	20.63	Yes	Yes	2	6	7
139	R:R:L206	R:R:Y143	15.24	No	Yes	0	5	7
140	R:R:H209	R:R:Y143	9.8	No	Yes	2	6	7
141	R:R:M210	R:R:Y143	3.59	Yes	Yes	2	9	7
142	R:R:I144	R:R:Y148	4.84	No	No	8	6	6
143	R:R:I144	R:R:I155	4.42	No	No	8	6	5
144	R:R:I144	R:R:V156	4.61	No	No	0	6	7
145	R:R:S145	R:R:Y152	8.9	No	Yes	0	9	8
146	R:R:F147	R:R:I146	3.77	Yes	No	2	6	8
147	R:R:I146	R:R:M210	5.83	No	Yes	2	8	9
148	R:R:F147	R:R:H209	23.76	Yes	No	2	6	6
149	R:R:F147	R:R:M210	3.73	Yes	Yes	2	6	9
150	R:R:F147	R:R:R213	7.48	Yes	No	0	6	6
151	R:R:I155	R:R:Y148	3.63	No	No	8	5	6
152	R:R:I155	R:R:R151	3.76	No	No	0	5	6
153	R:R:H153	R:R:Y152	8.71	No	Yes	0	5	8
154	R:R:V156	R:R:Y152	3.79	No	Yes	0	7	8
155	R:R:P159	R:R:T157	10.49	No	No	0	4	8
156	R:R:R160	R:R:T157	5.17	No	No	0	7	8
157	R:R:L158	R:R:R162	3.64	No	No	0	3	1
158	R:R:S172	R:R:W169	3.71	No	Yes	4	7	9
159	R:R:F179	R:R:V188	6.55	Yes	No	0	5	4
160	R:R:F179	R:R:L192	4.87	Yes	No	0	5	5
161	R:R:L189	R:R:L261	4.15	Yes	Yes	1	4	5
162	R:R:I264	R:R:L189	4.28	No	Yes	1	4	4
163	R:R:L189	R:R:V265	4.47	Yes	No	0	4	4
164	R:R:F258	R:R:L192	3.65	No	No	0	5	5
165	R:R:T262	R:R:V193	7.93	No	No	0	4	4
166	R:R:F195	R:R:M199	7.46	Yes	No	0	4	7
167	R:R:F196	R:R:F250	6.43	Yes	Yes	0	7	8
168	R:R:F196	R:R:F258	31.08	Yes	No	0	7	5
169	R:R:F250	R:R:L200	4.87	Yes	No	0	8	5
170	R:R:F251	R:R:L200	4.87	No	No	0	6	5
171	R:R:L202	R:R:L206	6.92	No	No	0	5	5
172	R:R:M203	R:R:Y207	4.79	No	Yes	0	8	8
173	R:R:F250	R:R:M203	6.22	Yes	No	0	8	8
174	R:R:M210	R:R:Y207	4.79	Yes	Yes	2	9	8
175	R:R:L246	R:R:Y207	4.69	Yes	Yes	0	8	8
176	R:R:L247	R:R:Y207	3.52	No	Yes	0	7	8
177	R:R:Q216	R:R:R213	10.51	No	No	0	4	6
178	R:R:H217	R:R:R213	9.03	No	No	0	8	6
179	R:R:H225	R:R:I221	6.63	No	No	0	4	7
180	R:R:G239	R:R:T242	3.64	No	No	0	8	9
181	R:R:I245	R:R:I297	4.42	No	Yes	0	7	8
182	R:R:L246	R:R:Y298	5.86	Yes	Yes	0	8	9
183	R:R:I249	R:R:I293	7.36	No	No	0	6	5
184	R:R:F250	R:R:W254	5.01	Yes	Yes	0	8	7
185	R:R:C253	R:R:L286	4.76	No	No	0	8	7
186	R:R:C253	R:R:N290	9.45	No	No	0	8	9
187	R:R:I287	R:R:W254	14.09	No	Yes	6	7	7
188	R:R:N290	R:R:W254	20.34	No	Yes	0	9	7
189	R:R:G255	R:R:P256	4.06	No	No	0	5	9
190	R:R:F283	R:R:P256	13	No	No	0	5	9
191	R:R:F257	R:R:F258	11.79	Yes	No	0	5	5
192	R:R:F257	R:R:L261	10.96	Yes	Yes	0	5	5
193	R:R:F257	R:R:I287	5.02	Yes	No	0	5	7
194	R:R:L259	R:R:L263	6.92	No	Yes	0	6	4
195	R:R:H260	R:R:I264	9.28	No	No	1	4	4
196	R:R:F277	R:R:H260	9.05	Yes	No	1	3	4
197	R:R:F280	R:R:H260	13.58	No	No	0	4	4
198	R:R:C267	R:R:L263	6.35	No	Yes	1	3	4
199	R:R:C273	R:R:L263	9.52	Yes	Yes	1	4	4
200	R:R:I276	R:R:L263	4.28	No	Yes	0	4	4
201	R:R:F277	R:R:I264	3.77	Yes	No	1	3	4
202	R:R:C267	R:R:C273	7.28	No	Yes	1	3	4
203	R:R:H270	R:R:P271	9.15	No	No	0	4	3
204	R:R:H270	R:R:T272	5.48	No	No	0	4	4
205	R:R:C273	R:R:H270	5.9	Yes	No	0	4	4
206	R:R:C273	R:R:F277	4.19	Yes	Yes	1	4	3
207	R:R:F277	R:R:G274	6.02	Yes	No	0	3	2
208	R:R:F283	R:R:N279	3.62	No	No	0	5	4
209	R:R:F283	R:R:L282	6.09	No	No	0	5	3
210	R:R:L282	R:R:L286	4.15	No	No	0	3	7
211	R:R:D294	R:R:N290	4.04	No	No	0	9	9
212	R:R:H301	R:R:I297	5.3	No	Yes	0	7	8
213	R:R:L305	R:R:S302	6.01	Yes	No	3	8	8
214	R:R:Q303	R:R:R306	7.01	No	No	0	6	9
215	R:R:A291	R:R:S52	3.42	No	Yes	0	9	8
216	R:R:L86	R:R:W169	3.42	No	Yes	0	7	9
217	R:R:A81	R:R:V59	3.39	No	Yes	0	9	9
218	R:R:H185	R:R:Y182	3.27	No	No	0	4	4
219	R:R:C275	R:R:K278	3.23	No	No	0	3	2
220	R:R:F175	R:R:F179	3.22	No	Yes	0	4	5
221	R:R:V186	R:R:V265	3.21	No	No	0	1	4
222	R:R:C215	R:R:L211	3.17	No	No	0	5	6
223	R:R:C267	R:R:L266	3.17	No	No	0	3	3
224	R:R:A105	R:R:L100	3.15	No	No	0	4	4
225	R:R:A299	R:R:L305	3.15	No	Yes	0	8	8
226	R:R:T308	R:R:T62	3.14	No	No	0	8	8
227	R:R:L44	R:R:S41	3	No	No	0	5	5
228	R:R:L48	R:R:S47	3	No	No	0	6	3
229	R:R:L86	R:R:S127	3	No	No	0	7	7
230	R:R:L46	R:R:V92	2.98	No	No	0	5	6
231	R:R:L101	R:R:V97	2.98	No	No	0	3	4
232	R:R:L206	R:R:V140	2.98	No	No	0	5	6
233	R:R:L190	R:R:V194	2.98	No	No	0	4	4
234	R:R:L261	R:R:V193	2.98	Yes	No	0	5	4
235	R:R:L243	R:R:V208	2.98	No	No	0	8	4
236	R:R:L99	R:R:T95	2.95	No	Yes	0	4	5
237	R:R:L246	R:R:T242	2.95	Yes	No	0	8	9
238	R:R:I138	R:R:I77	2.94	Yes	No	0	9	7
239	R:R:I293	R:R:I297	2.94	No	Yes	0	5	8
240	R:R:I292	R:R:L48	2.85	No	No	0	5	6
241	R:R:I297	R:R:L246	2.85	Yes	Yes	0	8	8
242	R:R:C191	R:R:F179	2.79	No	Yes	0	4	5
243	R:R:A161	R:R:F76	2.77	No	Yes	0	6	7
244	R:R:A164	R:R:F76	2.77	No	Yes	0	6	7
245	R:R:A171	R:R:F175	2.77	No	No	0	3	4
246	R:R:L211	R:R:L243	2.77	No	No	0	6	8
247	R:R:L243	R:R:L247	2.77	No	No	0	8	7
248	R:R:R307	R:R:T308	2.59	No	No	0	6	8
249	R:R:F196	R:R:L197	2.44	Yes	No	0	7	4
250	L:L:Y2	R:R:L113	2.34	No	Yes	0	0	6
251	R:R:L178	R:R:Y182	2.34	No	No	0	5	4
252	R:R:A139	R:R:G136	1.95	No	No	0	9	7
253	R:R:G49	R:R:S52	1.86	No	Yes	7	6	8
254	R:R:G49	R:R:S88	1.86	No	Yes	7	6	9
255	R:R:G89	R:R:S88	1.86	No	Yes	0	3	9
256	R:R:G49	R:R:V92	1.84	No	No	0	6	6
257	R:R:G89	R:R:V92	1.84	No	No	0	3	6
258	R:R:C75	R:R:C79	1.82	No	No	0	4	9
259	R:R:C253	R:R:C289	1.82	No	No	0	8	4
260	R:R:A103	R:R:A105	1.79	No	No	0	5	4
261	R:R:G239	R:R:K238	1.74	No	No	0	8	8
262	R:R:C78	R:R:V60	1.71	No	No	0	6	7
263	R:R:L158	R:R:P159	1.64	No	No	0	3	4
264	R:R:G220	R:R:Q219	1.64	No	No	0	5	4
265	R:R:S39	R:R:S41	1.63	No	No	0	2	5
266	R:R:A61	R:R:K65	1.61	No	No	0	4	5
267	R:R:V201	R:R:V205	1.6	No	No	0	4	4
268	R:R:C75	R:R:L158	1.59	No	No	0	4	3
269	R:R:T177	R:R:V122	1.59	No	No	0	4	5
270	R:R:T177	R:R:V173	1.59	No	No	0	4	3
271	R:R:A57	R:R:L85	1.58	No	No	0	5	7
272	R:R:A108	R:R:L113	1.58	No	Yes	0	1	6
273	R:R:A204	R:R:L247	1.58	No	No	0	4	7
274	R:R:A214	R:R:L211	1.58	No	No	0	8	6
275	R:R:A240	R:R:L237	1.58	No	No	0	7	5
276	R:R:E55	R:R:P295	1.57	No	No	0	8	9
277	R:R:E269	R:R:P268	1.57	No	No	0	1	3
278	R:R:I120	R:R:V119	1.54	Yes	No	0	5	4
279	R:R:G220	R:R:R223	1.5	No	No	0	5	3
280	R:R:L58	R:R:V54	1.49	No	No	0	7	4
281	R:R:L82	R:R:V60	1.49	No	No	0	6	7
282	R:R:L178	R:R:V174	1.49	No	No	0	5	4
283	R:R:L178	R:R:T177	1.47	No	No	0	5	4
284	L:L:V13	R:R:D184	1.46	No	No	0	0	4
285	R:R:A212	R:R:H209	1.46	No	No	0	3	6
286	R:R:I120	R:R:L93	1.43	Yes	No	0	5	8
287	R:R:I297	R:R:L296	1.43	Yes	No	0	8	5
288	R:R:K65	R:R:N66	1.4	No	Yes	0	5	8
289	R:R:D42	R:R:L99	1.36	No	No	0	3	4
290	R:R:A181	R:R:Y182	1.33	No	No	0	3	4
291	R:R:H225	R:R:L224	1.29	No	No	0	4	5
292	R:R:R160	R:R:R163	1.07	No	No	0	7	3
293	R:R:F300	R:R:R306	1.07	No	No	0	5	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:M4	5.7275	4	0	0
2	L:L:H6	8.8725	4	5	0
3	L:L:F7	6.18	6	0	0
4	L:L:R8	8.87857	7	1	0
5	L:L:W9	8.1225	4	1	0
6	R:R:F45	9.41833	6	5	6
7	R:R:S52	4.09	4	7	8
8	R:R:V59	4.3125	4	0	9
9	R:R:N66	8.0575	4	3	8
10	R:R:L69	6.18667	6	3	8
11	R:R:Y74	6.98833	6	3	8
12	R:R:F76	3.9175	4	0	7
13	R:R:L80	5.074	5	2	9
14	R:R:S83	5.4075	4	4	8
15	R:R:D84	6.642	5	2	9
16	R:R:S88	4.03	4	7	9
17	R:R:N91	7.392	5	5	7
18	R:R:T95	5.5275	4	5	5
19	R:R:L113	3.015	4	0	6
20	R:R:D117	8.635	4	1	6
21	R:R:I120	4.576	5	0	5
22	R:R:D121	8.77	5	1	5
23	R:R:S130	7.88	4	4	7
24	R:R:F134	7.81667	6	4	8
25	R:R:I138	4.88	4	2	9
26	R:R:R142	6.095	4	2	9
27	R:R:Y143	12.315	4	2	7
28	R:R:F147	11.874	5	2	6
29	R:R:Y152	7.935	4	0	8
30	R:R:W169	7.384	5	4	9
31	R:R:F179	4.216	5	0	5
32	R:R:I180	4.5175	4	1	5
33	R:R:L189	7.21	4	1	4
34	R:R:F195	5.9575	4	0	4
35	R:R:F196	10.9	4	0	7
36	R:R:Y207	5.44833	6	2	8
37	R:R:M210	4.332	5	2	9
38	R:R:L246	4.0875	4	0	8
39	R:R:F250	5.236	5	0	8
40	R:R:W254	11.102	5	6	7
41	R:R:F257	8.015	4	0	5
42	R:R:L261	5.945	4	1	5
43	R:R:L263	6.7675	4	1	4
44	R:R:C273	6.7225	4	1	4
45	R:R:F277	6.34	5	1	3
46	R:R:I297	3.388	5	0	8
47	R:R:Y298	5.49	5	2	9
48	R:R:L305	4.5	4	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:M4	R:R:V97	41.8343	6.09	Yes	No	0	0	4
2	R:R:L101	R:R:V97	38.2235	2.98	No	No	0	3	4
3	R:R:L101	R:R:L113	19.2048	4.15	No	Yes	0	3	6
4	L:L:M4	R:R:E94	21.651	4.06	Yes	No	0	0	4
5	L:L:M4	R:R:D117	27.5221	6.93	Yes	Yes	0	0	6
6	L:L:F7	R:R:D121	65.7387	9.55	Yes	Yes	0	0	5
7	R:R:D121	R:R:E94	29.7891	6.5	Yes	No	0	5	4
8	R:R:D117	R:R:D121	23.4909	9.31	Yes	Yes	1	6	5
9	L:L:F7	R:R:T124	10.8186	9.08	Yes	No	0	0	5
10	L:L:F7	R:R:M128	100	6.22	Yes	No	0	0	5
11	L:L:F7	R:R:F280	33.0072	4.29	Yes	No	0	0	4
12	L:L:F7	R:R:L284	25.696	3.65	Yes	No	0	0	4
13	R:R:F45	R:R:L284	12.8997	7.31	Yes	No	5	6	4
14	R:R:L284	R:R:N91	11.1907	4.12	No	Yes	5	4	7
15	R:R:D121	R:R:I180	22.8018	4.2	Yes	Yes	1	5	5
16	R:R:F277	R:R:H260	26.6607	9.05	Yes	No	1	3	4
17	R:R:F280	R:R:H260	29.7133	13.58	No	No	0	4	4
18	R:R:M128	R:R:W254	99.8966	5.82	No	Yes	6	5	7
19	R:R:N290	R:R:W254	69.4184	20.34	No	Yes	0	9	7
20	R:R:C253	R:R:N290	28.4523	9.45	No	No	0	8	9
21	R:R:C253	R:R:L286	24.5521	4.76	No	No	0	8	7
22	R:R:L282	R:R:L286	22.5813	4.15	No	No	0	3	7
23	R:R:F283	R:R:L282	20.5967	6.09	No	No	0	5	3
24	R:R:F283	R:R:N279	14.5604	3.62	No	No	0	5	4
25	R:R:N279	R:R:V38	12.5207	4.43	No	No	0	4	5
26	R:R:D294	R:R:N290	66.731	4.04	No	No	0	9	9
27	R:R:D294	R:R:D84	59.5232	10.65	No	Yes	2	9	9
28	R:R:A291	R:R:D84	37.4518	4.63	No	Yes	0	9	9
29	R:R:A291	R:R:S52	35.4879	3.42	No	Yes	0	9	8
30	R:R:I292	R:R:S52	15.091	6.19	No	Yes	0	5	8
31	R:R:I292	R:R:L48	10.8462	2.85	No	No	0	5	6
32	R:R:S52	R:R:S88	10.7084	4.89	Yes	Yes	7	8	9
33	R:R:D84	R:R:N56	80.1406	8.08	Yes	No	0	9	9
34	R:R:N56	R:R:P295	78.5074	6.52	No	No	0	9	9
35	R:R:P295	R:R:V59	75.1998	3.53	No	Yes	0	9	9
36	R:R:A299	R:R:V59	66.6896	5.09	No	Yes	0	8	9
37	R:R:A299	R:R:L305	64.9463	3.15	No	Yes	0	8	8
38	R:R:L305	R:R:L69	25.8751	4.15	Yes	Yes	3	8	8
39	R:R:L69	R:R:N66	12.9341	6.87	Yes	Yes	3	8	8
40	R:R:L305	R:R:Y74	35.4052	4.69	Yes	Yes	3	8	8
41	R:R:S71	R:R:Y74	14.4983	6.36	No	Yes	3	7	8
42	R:R:P72	R:R:S71	12.5413	3.56	No	No	0	7	7
43	R:R:M73	R:R:Y74	18.6949	9.58	No	Yes	3	8	8
44	R:R:P72	R:R:V156	10.481	3.53	No	No	0	7	7
45	R:R:D141	R:R:M73	16.7792	4.16	No	No	0	9	8
46	R:R:L132	R:R:W254	20.0248	10.25	No	Yes	0	7	7
47	R:R:F195	R:R:L132	21.7475	7.31	Yes	No	0	4	7
48	R:R:C133	R:R:F195	14.6362	4.19	No	Yes	0	4	4
49	R:R:C133	R:R:I168	13.575	8.18	No	No	0	4	6
50	R:R:F134	R:R:I168	13.2511	11.3	Yes	No	0	8	6
51	R:R:C79	R:R:F134	23.1464	9.78	No	Yes	4	9	8
52	R:R:I180	R:R:V122	27.5565	4.61	Yes	No	0	5	5
53	R:R:T177	R:R:V122	26.7985	1.59	No	No	0	4	5
54	R:R:T177	R:R:V173	26.5091	1.59	No	No	0	4	3
55	R:R:S126	R:R:V173	27.8115	4.85	No	No	0	5	3
56	R:R:S126	R:R:S172	32.7729	6.52	No	No	0	5	7
57	R:R:S130	R:R:S172	15.9385	6.52	Yes	No	4	7	7
58	R:R:S172	R:R:W169	18.5571	3.71	No	Yes	4	7	9
59	R:R:F250	R:R:W254	48.105	5.01	Yes	Yes	0	8	7
60	R:R:F250	R:R:L135	23.8492	3.65	Yes	No	0	8	8
61	R:R:I138	R:R:L80	22.2368	4.28	Yes	Yes	2	9	9
62	R:R:L135	R:R:Y298	13.9195	4.69	No	Yes	2	8	9
63	R:R:D84	R:R:S131	40.3597	4.42	Yes	No	0	9	9
64	R:R:S131	R:R:S83	38.9333	6.52	No	Yes	0	9	8
65	R:R:S130	R:R:S83	10.984	4.89	Yes	Yes	4	7	8
66	R:R:S83	R:R:W169	15.1392	4.94	Yes	Yes	4	8	9
67	R:R:L101	R:R:L106	15.5113	5.54	No	No	0	3	3
68	R:R:L100	R:R:L106	11.6524	6.92	No	No	0	4	3
69	R:R:F257	R:R:I287	14.0711	5.02	Yes	No	0	5	7
70	R:R:F257	R:R:F258	14.5535	11.79	Yes	No	0	5	5
71	R:R:F258	R:R:L192	11.2252	3.65	No	No	0	5	5
72	R:R:F196	R:R:F258	13.9471	31.08	Yes	No	0	7	5
73	R:R:R142	R:R:Y298	18.4537	6.17	Yes	Yes	2	9	9
74	R:R:F250	R:R:M203	38.8093	6.22	Yes	No	0	8	8
75	R:R:M203	R:R:Y207	37.2037	4.79	No	Yes	0	8	8
76	R:R:R142	R:R:Y207	13.6646	8.23	Yes	Yes	2	9	8
77	R:R:M210	R:R:Y207	17.0824	4.79	Yes	Yes	2	9	8
78	R:R:F147	R:R:M210	16.2142	3.73	Yes	Yes	2	6	9
79	R:R:M210	R:R:Y143	16.4967	3.59	Yes	Yes	2	9	7
80	R:R:C75	R:R:C79	20.3487	1.82	No	No	0	4	9
81	R:R:C75	R:R:L158	17.4821	1.59	No	No	0	4	3
82	R:R:L158	R:R:P159	11.7076	1.64	No	No	0	3	4
83	R:R:L246	R:R:Y298	24.6486	5.86	Yes	Yes	0	8	9
84	R:R:L246	R:R:Y207	17.9851	4.69	Yes	Yes	0	8	8
85	R:R:L247	R:R:Y207	22.5193	3.52	No	Yes	0	7	8
86	R:R:I297	R:R:L246	18.1436	2.85	Yes	Yes	0	8	8
87	R:R:C273	R:R:F277	20.0248	4.19	Yes	Yes	1	4	3
88	R:R:L178	R:R:T177	14.0504	1.47	No	No	0	5	4
89	R:R:L243	R:R:L247	16.1521	2.77	No	No	0	8	7
90	R:R:F257	R:R:L261	20.6312	10.96	Yes	Yes	0	5	5
91	R:R:F196	R:R:F250	14.9531	6.43	Yes	Yes	0	7	8
92	R:R:I287	R:R:W254	14.2434	14.09	No	Yes	6	7	7
93	R:R:F134	R:R:S83	12.2313	5.28	Yes	Yes	4	8	8
94	R:R:L80	R:R:Y298	32.3319	4.69	Yes	Yes	2	9	9
95	R:R:I138	R:R:R142	17.5648	6.26	Yes	Yes	2	9	9
96	R:R:M210	R:R:R142	20.8655	3.72	Yes	Yes	2	9	9
97	R:R:D84	R:R:L80	53.2387	5.43	Yes	Yes	2	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Y2	R:R:A110	5.34	0	No	No	0	3	0	1
L:L:M4	R:R:E94	4.06	0	Yes	No	0	4	0	1
L:L:M4	R:R:V97	6.09	0	Yes	No	0	4	0	1
L:L:M4	R:R:I98	5.83	0	Yes	No	0	3	0	1
L:L:M4	R:R:D117	6.93	0	Yes	Yes	0	6	0	1
L:L:E5	R:R:D117	5.2	1	No	Yes	0	6	0	1
L:L:H6	R:R:F45	18.1	5	Yes	Yes	0	6	0	1
L:L:H6	R:R:N91	3.83	5	Yes	Yes	0	7	0	1
L:L:H6	R:R:T95	9.58	5	Yes	Yes	0	5	0	1
L:L:H6	R:R:I98	3.98	5	Yes	No	0	3	0	1
L:L:F7	R:R:D121	9.55	0	Yes	Yes	0	5	0	1
L:L:F7	R:R:T124	9.08	0	Yes	No	0	5	0	1
L:L:F7	R:R:M128	6.22	0	Yes	No	0	5	0	1
L:L:F7	R:R:F257	4.29	0	Yes	Yes	0	5	0	1
L:L:F7	R:R:F280	4.29	0	Yes	No	0	4	0	1
L:L:F7	R:R:L284	3.65	0	Yes	No	0	4	0	1
L:L:R8	R:R:D117	13.1	1	Yes	Yes	0	6	0	1
L:L:R8	R:R:N118	4.82	1	Yes	No	0	4	0	1
L:L:R8	R:R:D121	14.29	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:I180	5.01	1	Yes	Yes	0	5	0	1
L:L:R8	R:R:Y183	5.14	1	Yes	No	0	3	0	1
L:L:W9	R:R:Y183	3.86	1	Yes	No	0	3	0	1
L:L:W9	R:R:L189	15.94	1	Yes	Yes	0	4	0	1
L:L:W9	R:R:L261	5.69	1	Yes	Yes	0	5	0	1
L:L:G10	R:R:F280	10.54	0	No	No	0	4	0	1
L:L:P12	R:R:P268	3.9	0	No	No	0	3	0	1
L:L:P12	R:R:F277	8.67	0	No	Yes	0	3	0	1
L:L:V13	R:R:Y183	3.79	0	No	No	0	3	0	1
R:R:F45	R:R:N91	13.29	5	Yes	Yes	6	7	1	1
R:R:F45	R:R:T95	5.19	5	Yes	Yes	6	5	1	1
R:R:F45	R:R:N281	8.46	5	Yes	No	6	4	1	2
R:R:F45	R:R:L284	7.31	5	Yes	No	6	4	1	1
R:R:A285	R:R:F45	4.16	0	No	Yes	5	6	2	1
R:R:I120	R:R:S90	4.64	0	Yes	No	5	5	2	2
R:R:S90	R:R:T124	7.99	0	No	No	5	5	2	1
R:R:N91	R:R:T95	4.39	5	Yes	Yes	7	5	1	1
R:R:L284	R:R:N91	4.12	5	No	Yes	4	7	1	1
R:R:I288	R:R:N91	11.33	0	No	Yes	6	7	2	1
R:R:E94	R:R:I120	9.56	0	No	Yes	4	5	1	2
R:R:D121	R:R:E94	6.5	1	Yes	No	5	4	1	1
R:R:L101	R:R:L113	4.15	0	No	Yes	3	6	2	1
R:R:L113	R:R:Q114	3.99	0	Yes	No	6	2	1	2
R:R:N118	R:R:Q115	6.6	1	No	No	4	1	1	2
R:R:D117	R:R:D121	9.31	1	Yes	Yes	6	5	1	1
R:R:I180	R:R:N118	4.25	1	Yes	No	5	4	1	1
R:R:D121	R:R:I180	4.2	1	Yes	Yes	5	5	1	1
R:R:I180	R:R:V122	4.61	1	Yes	No	5	5	1	2
R:R:M128	R:R:W254	5.82	6	No	Yes	5	7	1	2
R:R:I287	R:R:M128	4.37	6	No	No	7	5	2	1
R:R:L189	R:R:L261	4.15	1	Yes	Yes	4	5	1	1
R:R:I264	R:R:L189	4.28	1	No	Yes	4	4	2	1
R:R:L189	R:R:V265	4.47	1	Yes	No	4	4	1	2
R:R:I287	R:R:W254	14.09	6	No	Yes	7	7	2	2
R:R:F257	R:R:F258	11.79	0	Yes	No	5	5	1	2
R:R:F257	R:R:L261	10.96	0	Yes	Yes	5	5	1	1
R:R:F257	R:R:I287	5.02	0	Yes	No	5	7	1	2
R:R:H260	R:R:I264	9.28	1	No	No	4	4	2	2
R:R:F277	R:R:H260	9.05	1	Yes	No	3	4	1	2
R:R:F280	R:R:H260	13.58	0	No	No	4	4	1	2
R:R:F277	R:R:I264	3.77	1	Yes	No	3	4	1	2
R:R:C273	R:R:F277	4.19	1	Yes	Yes	4	3	2	1
R:R:F277	R:R:G274	6.02	1	Yes	No	3	2	1	2
R:R:L101	R:R:V97	2.98	0	No	No	3	4	2	1
R:R:L261	R:R:V193	2.98	1	Yes	No	5	4	1	2
R:R:L99	R:R:T95	2.95	0	No	Yes	4	5	2	1
L:L:Y2	R:R:L113	2.34	0	No	Yes	0	6	0	1
R:R:A108	R:R:L113	1.58	0	No	Yes	1	6	2	1
R:R:E269	R:R:P268	1.57	0	No	No	1	3	2	1
L:L:V13	R:R:D184	1.46	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F4D_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	252
Number of Links	293
Number of Hubs	48
Number of Links mediated by Hubs	172
Number of Communities	8
Number of Nodes involved in Communities	59
Number of Links involved in Communities	85

Path Summary
Number Of Nodes in MetaPath	98
Number Of Links MetaPath	97
Number of Shortest Paths	44675
Length Of Smallest Path	3
Average Path Length	12.1695
Length of Longest Path	27
Minimum Path Strength	1.48
Average Path Strength	6.10193
Maximum Path Strength	21.435
Minimum Path Correlation	0.7
Average Path Correlation	0.928207
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	54.8577
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.3533
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>7F4D_nogp_Chain_R L E V S I S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	9K3P	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3P (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-		2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004

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