psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E37	R:R:K278	6.75	No	No	0	2	2
2	R:R:I40	R:R:V38	3.07	No	No	0	6	5
3	R:R:N279	R:R:V38	4.43	No	No	0	4	5
4	R:R:L282	R:R:V38	4.47	No	No	0	3	5
5	R:R:F45	R:R:I40	3.77	No	No	0	6	6
6	R:R:N281	R:R:S41	4.47	No	No	0	4	5
7	R:R:D42	R:R:G43	3.35	No	No	0	3	5
8	R:R:F45	R:R:L284	7.31	No	No	0	6	4
9	L:L:H3	R:R:F45	9.05	No	No	0	0	6
10	R:R:L46	R:R:L50	4.15	No	No	2	5	5
11	R:R:L46	R:R:V92	2.98	No	No	2	5	6
12	R:R:L46	R:R:T95	2.95	No	No	0	5	5
13	R:R:I288	R:R:L48	7.14	No	No	0	6	6
14	R:R:L50	R:R:V92	4.47	No	No	2	5	6
15	R:R:I292	R:R:V51	3.07	No	No	0	5	5
16	R:R:N56	R:R:S52	5.96	Yes	Yes	2	9	8
17	R:R:S52	R:R:S88	6.52	Yes	Yes	2	8	9
18	R:R:I288	R:R:S52	3.1	No	Yes	0	6	8
19	R:R:A291	R:R:S52	3.42	No	Yes	0	9	8
20	R:R:I292	R:R:S52	4.64	No	Yes	0	5	8
21	R:R:L53	R:R:S88	7.51	No	Yes	2	5	9
22	R:R:G89	R:R:L53	5.13	No	No	2	3	5
23	R:R:L53	R:R:V92	4.47	No	No	2	5	6
24	R:R:L58	R:R:V54	2.98	No	No	0	7	4
25	R:R:D84	R:R:N56	4.04	Yes	Yes	0	9	9
26	R:R:L85	R:R:N56	6.87	No	Yes	0	7	9
27	R:R:N56	R:R:S88	2.98	Yes	Yes	2	9	9
28	R:R:N56	R:R:P295	3.26	Yes	No	0	9	9
29	R:R:A81	R:R:V59	5.09	No	Yes	0	9	9
30	R:R:P295	R:R:V59	3.53	No	Yes	0	9	9
31	R:R:A299	R:R:V59	5.09	No	Yes	0	8	9
32	R:R:F300	R:R:V59	3.93	No	Yes	0	5	9
33	R:R:C78	R:R:V60	5.12	No	No	0	6	7
34	R:R:L305	R:R:T62	2.95	No	No	0	8	8
35	R:R:T308	R:R:T62	3.14	No	No	0	8	8
36	R:R:C78	R:R:I63	9.82	No	No	0	6	8
37	R:R:E311	R:R:K65	4.05	No	No	0	4	5
38	R:R:N66	R:R:T308	8.77	No	No	0	8	8
39	R:R:C75	R:R:H70	2.95	No	No	6	4	8
40	R:R:H70	R:R:L158	3.86	No	Yes	6	8	3
41	R:R:P72	R:R:S71	3.56	No	No	0	7	7
42	R:R:S71	R:R:Y74	3.82	No	No	0	7	8
43	R:R:P72	R:R:V156	3.53	No	No	0	7	7
44	R:R:L158	R:R:P72	4.93	Yes	No	0	3	7
45	R:R:M73	R:R:Y74	11.97	No	No	0	8	8
46	R:R:I77	R:R:M73	4.37	No	No	0	7	8
47	R:R:S302	R:R:Y74	7.63	No	No	0	8	8
48	R:R:C75	R:R:L158	3.17	No	Yes	6	4	3
49	R:R:A137	R:R:F76	4.16	No	Yes	0	7	7
50	R:R:D141	R:R:F76	3.58	No	Yes	0	9	7
51	R:R:A161	R:R:F76	4.16	No	Yes	0	6	7
52	R:R:C79	R:R:F134	9.78	No	Yes	4	9	8
53	R:R:C79	R:R:V165	8.54	No	No	4	9	7
54	R:R:D84	R:R:L80	4.07	Yes	No	0	9	9
55	R:R:L82	R:R:W169	3.42	No	Yes	0	6	9
56	R:R:S130	R:R:S83	6.52	No	No	4	7	8
57	R:R:F134	R:R:S83	3.96	Yes	No	4	8	8
58	R:R:S83	R:R:W169	7.41	No	Yes	4	8	9
59	R:R:D84	R:R:S131	5.89	Yes	No	0	9	9
60	R:R:A291	R:R:D84	6.18	No	Yes	0	9	9
61	R:R:L86	R:R:S127	3	No	No	0	7	7
62	R:R:S127	R:R:V87	4.85	No	No	0	7	8
63	R:R:M128	R:R:V87	4.56	Yes	No	0	5	8
64	R:R:G89	R:R:S88	3.71	No	Yes	2	3	9
65	R:R:I123	R:R:S90	7.74	No	No	0	4	5
66	R:R:S90	R:R:T124	4.8	No	No	0	5	5
67	R:R:N91	R:R:T124	4.39	No	No	0	7	5
68	R:R:I288	R:R:N91	4.25	No	No	0	6	7
69	R:R:E94	R:R:I98	4.1	Yes	Yes	0	4	3
70	R:R:D121	R:R:E94	5.2	Yes	Yes	1	5	4
71	L:L:?4	R:R:E94	10.62	Yes	Yes	1	0	4
72	L:L:H3	R:R:T95	6.85	No	No	0	0	5
73	R:R:L101	R:R:V97	2.98	No	No	0	3	4
74	L:L:?1	R:R:I98	10.71	No	Yes	0	0	3
75	L:L:H3	R:R:I98	7.95	No	Yes	0	0	3
76	R:R:L101	R:R:L113	4.15	No	No	0	3	6
77	R:R:R109	R:R:V112	9.15	No	No	0	3	3
78	L:L:?1	R:R:L113	5.19	No	No	0	0	6
79	R:R:I120	R:R:L116	4.28	No	No	0	5	3
80	R:R:D117	R:R:D121	9.31	No	Yes	0	6	5
81	L:L:?1	R:R:D117	15.27	No	No	0	0	6
82	R:R:I180	R:R:N118	4.25	Yes	No	0	5	4
83	L:L:?4	R:R:D121	8.7	Yes	Yes	1	0	5
84	L:L:R5	R:R:D121	13.1	Yes	Yes	1	0	5
85	R:R:S176	R:R:V122	4.85	No	No	0	7	5
86	R:R:I180	R:R:V122	7.68	Yes	No	0	5	5
87	R:R:C125	R:R:S176	6.89	No	No	0	4	7
88	R:R:C125	R:R:I180	3.27	No	Yes	0	4	5
89	L:L:?4	R:R:C125	7.63	Yes	No	0	0	4
90	R:R:S126	R:R:S172	3.26	No	No	0	5	7
91	R:R:S126	R:R:V173	4.85	No	No	0	5	3
92	R:R:S126	R:R:S176	3.26	No	No	0	5	7
93	R:R:M128	R:R:W254	6.98	Yes	Yes	1	5	7
94	R:R:I287	R:R:M128	7.29	No	Yes	1	7	5
95	L:L:?4	R:R:M128	4.53	Yes	Yes	1	0	5
96	R:R:F195	R:R:L129	3.65	No	No	0	4	5
97	R:R:S130	R:R:W169	14.83	No	Yes	4	7	9
98	R:R:S130	R:R:S172	4.89	No	No	0	7	7
99	R:R:F195	R:R:L132	7.31	No	No	0	4	7
100	R:R:L132	R:R:W254	9.11	No	Yes	0	7	7
101	R:R:C133	R:R:I168	8.18	No	No	0	4	6
102	R:R:F134	R:R:V165	5.24	Yes	No	4	8	7
103	R:R:F134	R:R:I168	12.56	Yes	No	0	8	6
104	R:R:F134	R:R:W169	7.02	Yes	Yes	4	8	9
105	R:R:D294	R:R:L135	4.07	No	No	3	9	8
106	R:R:L135	R:R:Y298	3.52	No	Yes	3	8	9
107	R:R:I138	R:R:R142	5.01	No	No	3	9	9
108	R:R:I138	R:R:Y298	6.04	No	Yes	3	9	9
109	R:R:A139	R:R:Y207	4	No	Yes	0	9	8
110	R:R:D141	R:R:Y152	8.05	No	Yes	0	9	8
111	R:R:R142	R:R:Y207	8.23	No	Yes	0	9	8
112	R:R:R142	R:R:Y298	6.17	No	Yes	3	9	9
113	R:R:F147	R:R:Y143	14.44	Yes	No	7	6	7
114	R:R:L206	R:R:Y143	10.55	No	No	0	5	7
115	R:R:H209	R:R:Y143	9.8	No	No	7	6	7
116	R:R:I144	R:R:I155	4.42	No	No	0	6	5
117	R:R:I144	R:R:V156	3.07	No	No	0	6	7
118	R:R:I146	R:R:S145	3.1	No	No	0	8	9
119	R:R:S145	R:R:Y152	8.9	No	Yes	0	9	8
120	R:R:F147	R:R:I146	3.77	Yes	No	0	6	8
121	R:R:F147	R:R:H209	18.1	Yes	No	7	6	6
122	R:R:I155	R:R:Y148	3.63	No	No	0	5	6
123	R:R:H153	R:R:Y152	8.71	No	Yes	0	5	8
124	R:R:V156	R:R:Y152	5.05	No	Yes	0	7	8
125	R:R:P159	R:R:T157	6.99	No	No	0	4	8
126	R:R:R160	R:R:T157	5.17	No	No	0	7	8
127	R:R:L158	R:R:R162	6.07	Yes	No	0	3	1
128	R:R:F175	R:R:F179	3.22	No	Yes	0	4	5
129	R:R:L178	R:R:Y182	4.69	No	No	0	5	4
130	R:R:F179	R:R:V188	7.87	Yes	No	0	5	4
131	R:R:F179	R:R:L192	6.09	Yes	No	0	5	5
132	L:L:R5	R:R:I180	6.26	Yes	Yes	0	0	5
133	R:R:D184	R:R:Y183	4.6	No	No	0	4	3
134	L:L:R5	R:R:Y183	16.46	Yes	No	1	0	3
135	L:L:W6	R:R:Y183	3.86	Yes	No	1	0	3
136	R:R:D184	R:R:H185	5.04	No	No	0	4	4
137	R:R:V186	R:R:V265	4.81	No	No	0	1	4
138	R:R:L189	R:R:V265	4.47	No	No	0	4	4
139	L:L:W6	R:R:L189	15.94	Yes	No	0	0	4
140	R:R:L190	R:R:V194	2.98	No	No	0	4	4
141	L:L:W6	R:R:L192	3.42	Yes	No	0	0	5
142	R:R:L197	R:R:V193	2.98	No	No	0	4	4
143	R:R:T262	R:R:V193	6.35	No	No	0	4	4
144	R:R:F195	R:R:M199	3.73	No	No	0	4	7
145	R:R:F196	R:R:L197	3.65	Yes	No	0	7	4
146	R:R:F196	R:R:F250	6.43	Yes	Yes	1	7	8
147	R:R:F196	R:R:W254	3.01	Yes	Yes	1	7	7
148	R:R:F196	R:R:G255	4.52	Yes	No	0	7	5
149	R:R:F196	R:R:F258	23.58	Yes	No	0	7	5
150	R:R:F250	R:R:L200	4.87	Yes	No	0	8	5
151	R:R:F251	R:R:L200	4.87	No	No	0	6	5
152	R:R:L202	R:R:L206	5.54	No	No	0	5	5
153	R:R:F250	R:R:M203	4.98	Yes	No	0	8	8
154	R:R:M210	R:R:Y207	8.38	No	Yes	0	9	8
155	R:R:L246	R:R:Y207	4.69	No	Yes	0	8	8
156	R:R:C215	R:R:L211	3.17	No	No	0	5	6
157	R:R:L211	R:R:L243	5.54	No	Yes	0	6	8
158	R:R:Q216	R:R:R213	8.18	No	No	0	4	6
159	R:R:H217	R:R:R213	12.41	No	No	0	8	6
160	R:R:G220	R:R:R223	4.5	No	No	0	5	3
161	R:R:I245	R:R:V241	3.07	No	No	0	7	7
162	R:R:L243	R:R:L247	5.54	Yes	No	0	8	7
163	R:R:L246	R:R:Y298	4.69	No	Yes	0	8	9
164	R:R:I249	R:R:I293	5.89	No	No	0	6	5
165	R:R:I249	R:R:I297	4.42	No	No	3	6	8
166	R:R:F250	R:R:W254	4.01	Yes	Yes	1	8	7
167	R:R:C253	R:R:N290	6.3	No	No	0	8	9
168	R:R:I287	R:R:W254	9.4	No	Yes	1	7	7
169	R:R:N290	R:R:W254	11.3	No	Yes	0	9	7
170	R:R:G255	R:R:P256	4.06	No	No	0	5	9
171	R:R:F283	R:R:P256	7.22	No	No	0	5	9
172	R:R:F257	R:R:F258	6.43	Yes	No	0	5	5
173	R:R:F257	R:R:L261	9.74	Yes	No	0	5	5
174	R:R:F257	R:R:F280	5.36	Yes	Yes	0	5	4
175	R:R:F257	R:R:I287	5.02	Yes	No	0	5	7
176	L:L:?4	R:R:F257	10.74	Yes	Yes	0	0	5
177	R:R:L259	R:R:L263	4.15	No	Yes	0	6	4
178	R:R:H260	R:R:I264	5.3	Yes	No	5	4	4
179	R:R:F277	R:R:H260	9.05	Yes	Yes	5	3	4
180	R:R:F280	R:R:H260	11.31	Yes	Yes	0	4	4
181	R:R:F283	R:R:H260	6.79	No	Yes	0	5	4
182	L:L:W6	R:R:L261	5.69	Yes	No	0	0	5
183	R:R:C267	R:R:L263	6.35	Yes	Yes	5	3	4
184	R:R:C273	R:R:L263	6.35	Yes	Yes	5	4	4
185	R:R:I276	R:R:L263	4.28	No	Yes	0	4	4
186	R:R:F277	R:R:I264	8.79	Yes	No	5	3	4
187	R:R:L266	R:R:V265	2.98	No	No	0	3	4
188	R:R:C267	R:R:H270	4.42	Yes	No	0	3	4
189	R:R:C267	R:R:C273	7.28	Yes	Yes	5	3	4
190	R:R:E269	R:R:H270	3.69	No	No	0	1	4
191	R:R:C273	R:R:F277	4.19	Yes	Yes	5	4	3
192	R:R:F280	R:R:N281	4.83	Yes	No	0	4	4
193	R:R:F280	R:R:L284	7.31	Yes	No	0	4	4
194	L:L:K7	R:R:F280	8.69	No	Yes	0	0	4
195	R:R:L282	R:R:L286	5.54	No	No	0	3	7
196	L:L:?4	R:R:L284	4.44	Yes	No	0	0	4
197	R:R:D294	R:R:N290	12.12	No	No	0	9	9
198	R:R:D294	R:R:Y298	5.75	No	Yes	3	9	9
199	R:R:I297	R:R:Y298	8.46	No	Yes	3	8	9
200	R:R:F300	R:R:L309	3.65	No	No	0	5	6
201	R:R:L305	R:R:S302	7.51	No	No	0	8	8
202	R:R:Q303	R:R:R306	18.69	No	No	0	6	9
203	R:R:Q303	R:R:R307	7.01	No	No	0	6	6
204	L:L:D2	L:L:K7	8.3	No	No	0	0	0
205	L:L:?4	L:L:R5	10.71	Yes	Yes	1	0	0
206	L:L:?4	L:L:W6	3.65	Yes	Yes	1	0	0
207	L:L:R5	L:L:W6	5	Yes	Yes	1	0	0
208	R:R:I138	R:R:I77	2.94	No	No	0	9	7
209	R:R:E304	R:R:S302	2.87	No	No	0	7	8
210	R:R:I63	R:R:L69	2.85	No	No	0	8	8
211	R:R:L247	R:R:M203	2.83	No	No	0	7	8
212	R:R:L305	R:R:L69	2.77	No	No	0	8	8
213	R:R:L100	R:R:L99	2.77	No	No	0	4	4
214	R:R:L101	R:R:L106	2.77	No	No	0	3	3
215	R:R:A171	R:R:F175	2.77	No	No	0	3	4
216	R:R:E94	R:R:I120	2.73	Yes	No	0	4	5
217	R:R:E102	R:R:I98	2.73	No	Yes	0	3	3
218	R:R:A181	R:R:Y182	2.67	No	No	0	3	4
219	R:R:E37	R:R:N279	2.63	No	No	0	2	4
220	R:R:I155	R:R:R151	2.51	No	No	0	5	6
221	R:R:F179	R:R:L178	2.44	Yes	No	0	5	5
222	R:R:Q219	R:R:R223	2.34	No	No	0	4	3
223	R:R:E55	R:R:F300	2.33	No	No	0	8	5
224	R:R:F147	R:R:R213	2.14	Yes	No	0	6	6
225	R:R:A105	R:R:G104	1.95	No	No	0	4	5
226	R:R:A139	R:R:G136	1.95	No	No	0	9	7
227	R:R:C267	R:R:P268	1.88	Yes	No	0	3	3
228	R:R:G49	R:R:S52	1.86	No	Yes	2	6	8
229	R:R:G49	R:R:S88	1.86	No	Yes	2	6	9
230	R:R:G239	R:R:T242	1.82	No	No	0	8	9
231	R:R:G239	R:R:L211	1.71	No	No	0	8	6
232	R:R:C273	R:R:T272	1.69	Yes	No	0	4	4
233	R:R:L158	R:R:P159	1.64	Yes	No	0	3	4
234	R:R:C289	R:R:I293	1.64	No	No	0	4	5
235	R:R:A285	R:R:I40	1.62	No	No	0	5	6
236	R:R:A222	R:R:K226	1.61	No	No	0	5	4
237	R:R:V170	R:R:V174	1.6	No	No	0	4	4
238	R:R:V201	R:R:V205	1.6	No	No	0	4	4
239	R:R:T177	R:R:V122	1.59	No	No	0	4	5
240	R:R:T177	R:R:V173	1.59	No	No	0	4	3
241	R:R:C253	R:R:L252	1.59	No	No	0	8	4
242	R:R:A57	R:R:L85	1.58	No	No	0	5	7
243	R:R:A204	R:R:L247	1.58	No	No	0	4	7
244	R:R:I144	R:R:V140	1.54	No	No	0	6	6
245	R:R:H270	R:R:P271	1.53	No	No	0	4	3
246	R:R:F277	R:R:G274	1.51	Yes	No	0	3	2
247	R:R:K238	R:R:T242	1.5	No	No	0	8	9
248	R:R:L243	R:R:V208	1.49	Yes	No	0	8	4
249	R:R:L237	R:R:V241	1.49	No	No	0	5	7
250	R:R:L243	R:R:T244	1.47	Yes	No	0	8	6
251	R:R:I245	R:R:I249	1.47	No	No	3	7	6
252	R:R:I245	R:R:I297	1.47	No	No	3	7	8
253	R:R:C191	R:R:F179	1.4	No	Yes	0	4	5
254	R:R:A164	R:R:F76	1.39	No	Yes	0	6	7
255	R:R:A111	R:R:R109	1.38	No	No	0	2	3
256	R:R:D42	R:R:L99	1.36	No	No	0	3	4
257	R:R:N66	R:R:N68	1.36	No	No	0	8	7
258	R:R:E55	R:R:L58	1.33	No	No	0	8	7
259	R:R:R151	R:R:S154	1.32	No	No	0	6	5
260	R:R:Q114	R:R:Q115	1.28	No	No	0	2	1

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S52	4.25	6	2	8
2	R:R:N56	4.622	5	2	9
3	R:R:V59	4.41	4	0	9
4	R:R:F76	3.3225	4	0	7
5	R:R:D84	5.045	4	0	9
6	R:R:S88	4.516	5	2	9
7	R:R:E94	5.6625	4	1	4
8	R:R:I98	6.3725	4	0	3
9	R:R:D121	9.0775	4	1	5
10	R:R:M128	5.84	4	1	5
11	R:R:F134	7.712	5	4	8
12	R:R:F147	9.6125	4	7	6
13	R:R:Y152	7.6775	4	0	8
14	R:R:L158	3.934	5	6	3
15	R:R:W169	8.17	4	4	9
16	R:R:F179	4.204	5	0	5
17	R:R:I180	5.365	4	0	5
18	R:R:F196	8.238	5	1	7
19	R:R:Y207	6.325	4	0	8
20	R:R:L243	3.51	4	0	8
21	R:R:F250	5.0725	4	1	8
22	R:R:W254	7.30167	6	1	7
23	R:R:F257	7.458	5	0	5
24	R:R:H260	8.1125	4	5	4
25	R:R:L263	5.2825	4	5	4
26	R:R:C267	4.9825	4	5	3
27	R:R:C273	4.8775	4	5	4
28	R:R:F277	5.885	4	5	3
29	R:R:F280	7.5	5	0	4
30	R:R:Y298	5.77167	6	3	9
31	L:L:?4	7.6275	8	1	0
32	L:L:R5	10.306	5	1	0
33	L:L:W6	6.26	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F45	R:R:I40	13.1011	3.77	No	No	0	6	6
2	R:R:F45	R:R:L284	57.464	7.31	No	No	0	6	4
3	R:R:F280	R:R:L284	20.4224	7.31	Yes	No	0	4	4
4	L:L:H3	R:R:F45	48.207	9.05	No	No	0	0	6
5	L:L:H3	R:R:T95	86.0568	6.85	No	No	0	0	5
6	R:R:L46	R:R:T95	83.6661	2.95	No	No	0	5	5
7	R:R:L46	R:R:V92	78.6403	2.98	No	No	2	5	6
8	R:R:L53	R:R:V92	76.4127	4.47	No	No	2	5	6
9	R:R:L53	R:R:S88	71.3257	7.51	No	Yes	2	5	9
10	R:R:S52	R:R:S88	26.5485	6.52	Yes	Yes	2	8	9
11	R:R:I288	R:R:S52	16.8636	3.1	No	Yes	0	6	8
12	R:R:N56	R:R:S88	39.928	2.98	Yes	Yes	2	9	9
13	R:R:N56	R:R:P295	25.0543	3.26	Yes	No	0	9	9
14	R:R:P295	R:R:V59	22.3241	3.53	No	Yes	0	9	9
15	R:R:F300	R:R:V59	14.0519	3.93	No	Yes	0	5	9
16	R:R:L305	R:R:S302	15.7023	7.51	No	No	0	8	8
17	R:R:S302	R:R:Y74	19.0437	7.63	No	No	0	8	8
18	R:R:M73	R:R:Y74	67.0198	11.97	No	No	0	8	8
19	R:R:I77	R:R:M73	68.2084	4.37	No	No	0	7	8
20	R:R:I138	R:R:I77	69.3833	2.94	No	No	0	9	7
21	R:R:I138	R:R:Y298	68.9419	6.04	No	Yes	3	9	9
22	R:R:D294	R:R:Y298	90.1793	5.75	No	Yes	3	9	9
23	R:R:D294	R:R:N290	92.4749	12.12	No	No	0	9	9
24	R:R:N290	R:R:W254	95.144	11.3	No	Yes	0	9	7
25	R:R:M128	R:R:W254	96.6042	6.98	Yes	Yes	1	5	7
26	L:L:?4	R:R:M128	100	4.53	Yes	Yes	1	0	5
27	L:L:?4	R:R:L284	58.3809	4.44	Yes	No	0	0	4
28	R:R:L158	R:R:P72	12.3064	4.93	Yes	No	0	3	7
29	R:R:P72	R:R:S71	50.3328	3.56	No	No	0	7	7
30	R:R:S71	R:R:Y74	51.6979	3.82	No	No	0	7	8
31	R:R:P72	R:R:V156	38.8957	3.53	No	No	0	7	7
32	R:R:V156	R:R:Y152	28.3279	5.05	No	Yes	0	7	8
33	R:R:S130	R:R:S83	11.8514	6.52	No	No	4	7	8
34	R:R:S130	R:R:S172	27.5672	4.89	No	No	0	7	7
35	R:R:S126	R:R:S172	29.4349	3.26	No	No	0	5	7
36	R:R:S126	R:R:S176	32.8783	3.26	No	No	0	5	7
37	R:R:C125	R:R:S176	37.1095	6.89	No	No	0	4	7
38	L:L:?4	R:R:C125	44.4241	7.63	Yes	No	0	0	4
39	R:R:S130	R:R:W169	13.8278	14.83	No	Yes	4	7	9
40	R:R:I288	R:R:N91	11.2945	4.25	No	No	0	6	7
41	L:L:?4	R:R:E94	50.3939	10.62	Yes	Yes	1	0	4
42	L:L:H3	R:R:I98	43.3306	7.95	No	Yes	0	0	3
43	R:R:E94	R:R:I98	49.3616	4.1	Yes	Yes	0	4	3
44	L:L:?1	R:R:L113	12.6392	5.19	No	No	0	0	6
45	L:L:?4	L:L:R5	12.8362	10.71	Yes	Yes	1	0	0
46	R:R:F257	R:R:F280	30.1684	5.36	Yes	Yes	0	5	4
47	R:R:F257	R:R:I287	14.9212	5.02	Yes	No	0	5	7
48	L:L:?4	R:R:F257	19.2611	10.74	Yes	Yes	0	0	5
49	R:R:S145	R:R:Y152	17.0606	8.9	No	Yes	0	9	8
50	R:R:I146	R:R:S145	15.383	3.1	No	No	0	8	9
51	R:R:F147	R:R:I146	13.6919	3.77	Yes	No	0	6	8
52	R:R:I144	R:R:V156	10.5882	3.07	No	No	0	6	7
53	L:L:?4	L:L:W6	31.0242	3.65	Yes	Yes	1	0	0
54	L:L:W6	R:R:L192	19.1932	3.42	Yes	No	0	0	5
55	R:R:F179	R:R:L192	17.1964	6.09	Yes	No	0	5	5
56	R:R:F257	R:R:F258	11.8446	6.43	Yes	No	0	5	5
57	R:R:F196	R:R:F258	10.9142	23.58	Yes	No	0	7	5
58	R:R:F250	R:R:W254	23.5738	4.01	Yes	Yes	1	8	7
59	R:R:F280	R:R:H260	34.9497	11.31	Yes	Yes	0	4	4
60	R:R:F250	R:R:M203	21.9573	4.98	Yes	No	0	8	8
61	R:R:L211	R:R:L243	10.1807	5.54	No	Yes	0	6	8
62	R:R:L243	R:R:L247	16.1301	5.54	Yes	No	0	8	7
63	R:R:L247	R:R:M203	20.0285	2.83	No	No	0	7	8
64	R:R:I297	R:R:Y298	12.3404	8.46	No	Yes	3	8	9
65	R:R:F277	R:R:H260	28.9256	9.05	Yes	Yes	5	3	4
66	R:R:C273	R:R:F277	24.3073	4.19	Yes	Yes	5	4	3
67	R:R:C267	R:R:C273	12.2181	7.28	Yes	Yes	5	3	4
68	R:R:I287	R:R:W254	13.3863	9.4	No	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F45	R:R:I40	3.77	0	No	No	6	6	1	2
R:R:F45	R:R:L284	7.31	0	No	No	6	4	1	1
L:L:H3	R:R:F45	9.05	0	No	No	0	6	0	1
R:R:L46	R:R:T95	2.95	2	No	No	5	5	2	1
R:R:M128	R:R:V87	4.56	1	Yes	No	5	8	1	2
R:R:E94	R:R:I98	4.1	1	Yes	Yes	4	3	1	1
R:R:D121	R:R:E94	5.2	1	Yes	Yes	5	4	1	1
L:L:?4	R:R:E94	10.62	1	Yes	Yes	0	4	0	1
L:L:H3	R:R:T95	6.85	0	No	No	0	5	0	1
L:L:?1	R:R:I98	10.71	0	No	Yes	0	3	0	1
L:L:H3	R:R:I98	7.95	0	No	Yes	0	3	0	1
R:R:L101	R:R:L113	4.15	0	No	No	3	6	2	1
L:L:?1	R:R:L113	5.19	0	No	No	0	6	0	1
R:R:D117	R:R:D121	9.31	0	No	Yes	6	5	1	1
L:L:?1	R:R:D117	15.27	0	No	No	0	6	0	1
R:R:I180	R:R:N118	4.25	0	Yes	No	5	4	1	2
L:L:?4	R:R:D121	8.7	1	Yes	Yes	0	5	0	1
L:L:R5	R:R:D121	13.1	1	Yes	Yes	0	5	0	1
R:R:S176	R:R:V122	4.85	0	No	No	7	5	2	2
R:R:I180	R:R:V122	7.68	0	Yes	No	5	5	1	2
R:R:C125	R:R:S176	6.89	0	No	No	4	7	1	2
R:R:C125	R:R:I180	3.27	0	No	Yes	4	5	1	1
L:L:?4	R:R:C125	7.63	1	Yes	No	0	4	0	1
R:R:M128	R:R:W254	6.98	1	Yes	Yes	5	7	1	2
R:R:I287	R:R:M128	7.29	1	No	Yes	7	5	2	1
L:L:?4	R:R:M128	4.53	1	Yes	Yes	0	5	0	1
R:R:F179	R:R:L192	6.09	0	Yes	No	5	5	2	1
L:L:R5	R:R:I180	6.26	1	Yes	Yes	0	5	0	1
R:R:D184	R:R:Y183	4.6	0	No	No	4	3	2	1
L:L:R5	R:R:Y183	16.46	1	Yes	No	0	3	0	1
L:L:W6	R:R:Y183	3.86	1	Yes	No	0	3	0	1
R:R:L189	R:R:V265	4.47	0	No	No	4	4	1	2
L:L:W6	R:R:L189	15.94	1	Yes	No	0	4	0	1
L:L:W6	R:R:L192	3.42	1	Yes	No	0	5	0	1
R:R:I287	R:R:W254	9.4	1	No	Yes	7	7	2	2
R:R:F257	R:R:F258	6.43	0	Yes	No	5	5	1	2
R:R:F257	R:R:L261	9.74	0	Yes	No	5	5	1	1
R:R:F257	R:R:F280	5.36	0	Yes	Yes	5	4	1	1
R:R:F257	R:R:I287	5.02	0	Yes	No	5	7	1	2
L:L:?4	R:R:F257	10.74	1	Yes	Yes	0	5	0	1
R:R:F280	R:R:H260	11.31	0	Yes	Yes	4	4	1	2
L:L:W6	R:R:L261	5.69	1	Yes	No	0	5	0	1
R:R:F280	R:R:N281	4.83	0	Yes	No	4	4	1	2
R:R:F280	R:R:L284	7.31	0	Yes	No	4	4	1	1
L:L:K7	R:R:F280	8.69	0	No	Yes	0	4	0	1
L:L:?4	R:R:L284	4.44	1	Yes	No	0	4	0	1
R:R:E94	R:R:I120	2.73	1	Yes	No	4	5	1	2
R:R:E102	R:R:I98	2.73	0	No	Yes	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7F4I_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.95
Number of Linked Nodes	240
Number of Links	260
Number of Hubs	33
Number of Links mediated by Hubs	126
Number of Communities	7
Number of Nodes involved in Communities	46
Number of Links involved in Communities	59

Path Summary
Number Of Nodes in MetaPath	69
Number Of Links MetaPath	68
Number of Shortest Paths	36467
Length Of Smallest Path	3
Average Path Length	13.9047
Length of Longest Path	35
Minimum Path Strength	1.48
Average Path Strength	6.14861
Maximum Path Strength	15.005
Minimum Path Correlation	0.7
Average Path Correlation	0.927491
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	49.5351
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	37.8929
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NLE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	NLE
Name	Norleucine
Synonyms	L-NORLEUCINE Norleucine
Identifier
Formula	C6 H13 N O2
Molecular Weight	131.173
SMILES
PubChem	6991974
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


Code	4J2
PDB Residues	L:L:?4
Environment Details	Open EMBL-EBI Page
Code	4J2
Name	(2R)-2-amino-3-(naphthalen-2-yl)propanoic acid
Synonyms
Identifier
Formula	C13 H13 N O2
Molecular Weight	215.248
SMILES
PubChem	2733661
Formal Charge	0
Total Atoms	29
Total Chiral Atoms	1
Total Bonds	30
Total Aromatic Bonds	11


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q01726
Sequence	>7F4I_nogp_Chain_R L E V S I S D G L F L S L G L V S L V E N A L V V A T I A K N R N L H S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G A L V A R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y A L R Y H S I V T L P R A R R A V A A I W V A S V V F S T L F I A Y Y D H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C P E H P T C G C I F K N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T L K E Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7F4D	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-	chim(NtGi1-Gs)/β1/γ2	3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4D (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	α-MSH	-		3	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4F (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.9	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-	chim(NtGi1-Gs)/β1/γ2	2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4H (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	Afamelanotide	-		2.7	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-	chim(NtGi1-Gs)/β1/γ2	3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	7F4I (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	SHU9119	-		3.1	2021-09-08	doi.org/10.1038/s41422-021-00557-y
	9K3P	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004
	9K3P (No Gprot)	A	Peptide	Melanocortin	MC₁	Homo sapiens	-	-		2.98	2025-08-06	doi.org/10.1016/j.str.2025.03.004

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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We apologize for the inconvenience.