Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I55 4.7775417
2R:R:N59 5.296519
3R:R:V62 3.728599
4R:R:I66 3.145407
5R:R:T76 3.3575408
6R:R:F79 4.2075408
7R:R:L83 4.544519
8R:R:D87 6.94519
9R:R:V95 3.078557
10R:R:F97 6.255474
11R:R:W107 7.02857777
12R:R:L108 3.4925404
13R:R:W109 9.52575
14R:R:W117 6.806506
15R:R:I129 4.75418
16R:R:L132 3.935418
17R:R:Y140 9.13408
18R:R:W166 4.425409
19R:R:F174 6.02435
20R:R:I177 5.446536
21R:R:M178 3.84434
22R:R:W182 7.08167635
23R:R:Y193 6.485433
24R:R:T203 5.765434
25R:R:Y207 5.466537
26R:R:F216 9.435407
27R:R:L220 4.3275406
28R:R:M223 4.99618
29R:R:E285 2.745407
30R:R:M296 3.7125418
31R:R:F299 6.046509
32R:R:W303 5.83833658
33R:R:L304 5.2175407
34R:R:F306 9.4675457
35R:R:F307 11.2325457
36R:R:F328 4.242505
37R:R:N329 8.095456
38R:R:W330 6.522556
39R:R:Y333 8.994557
40R:R:S336 6.52419
41R:R:N339 5.7925419
42R:R:P340 4.7625409
43R:R:F349 4.082598
44S:S:I55 4.7775427
45S:S:N59 5.296529
46S:S:V62 3.4665119
47S:S:I66 3.145407
48S:S:T76 3.67408
49S:S:F79 4.2075408
50S:S:L83 4.272529
51S:S:D87 6.668529
52S:S:V95 3.078567
53S:S:F97 5.755484
54S:S:W107 7.25286787
55S:S:L108 3.8275404
56S:S:W109 8.892585
57S:S:W117 6.806506
58S:S:I129 4.75428
59S:S:L132 3.63428
60S:S:Y140 9.13408
61S:S:W166 4.425409
62S:S:F174 6.02445
63S:S:I177 5.136546
64S:S:M178 3.84444
65S:S:W182 7.435645
66S:S:Y193 6.485443
67S:S:T203 5.765444
68S:S:Y207 5.466547
69S:S:F216 9.435407
70S:S:L220 4.3275406
71S:S:M223 4.99628
72S:S:E285 2.745407
73S:S:M296 3.7125428
74S:S:F299 6.002509
75S:S:W303 5.86668
76S:S:L304 5.565407
77S:S:F306 8.9675467
78S:S:F307 11.2325467
79S:S:F328 4.242505
80S:S:N329 8.3775466
81S:S:W330 6.716566
82S:S:Y333 9.188567
83S:S:S336 6.52429
84S:S:N339 5.7925429
85S:S:P340 4.7625409
86S:S:F349 3.825118
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:E41 R:R:Q38 22.202317.84NoNo053
2R:R:Q38 S:S:R104 22.207118.69NoNo034
3S:S:L108 S:S:R104 43.3872.43YesNo044
4R:R:Q39 S:S:L108 10.28247.99NoYes024
5R:R:E41 R:R:R104 22.20958.14NoNo054
6R:R:L108 R:R:R104 43.39542.43YesNo044
7R:R:L108 R:R:W109 39.44493.42YesYes045
8R:R:F97 R:R:W109 26.28869.02YesYes745
9R:R:F97 R:R:P96 54.9732.89YesNo049
10R:R:P96 R:R:V95 74.01183.53NoYes097
11R:R:V95 R:R:W330 14.57052.45YesYes576
12R:R:V102 R:R:W330 11.76623.68NoYes056
13R:R:M48 R:R:V102 10.61044.56NoNo065
14R:R:F97 R:R:W117 47.21137.02YesYes046
15R:R:W107 R:R:W109 23.855614.99YesYes775
16R:R:W107 R:R:W117 20.308814.06YesYes076
17S:S:L108 S:S:W109 39.29233.42YesYes045
18S:S:F97 S:S:W109 27.097.02YesYes845
19S:S:F97 S:S:P96 70.01082.89YesNo049
20S:S:P96 S:S:V95 81.45863.53NoYes097
21S:S:V95 S:S:W330 24.50682.45YesYes676
22S:S:V102 S:S:W330 11.6343.68NoYes056
23S:S:M48 S:S:V102 10.49384.56NoNo065
24S:S:F97 S:S:W117 60.91917.02YesYes046
25S:S:G98 S:S:W117 17.22465.63NoYes066
26S:S:G98 S:S:W330 17.5432.81NoYes066
27S:S:W107 S:S:W109 24.124714.99YesYes875
28S:S:W107 S:S:W117 21.459814.06YesYes076
29R:R:L46 S:S:P96 99.80661.64NoNo049
30R:R:L46 S:S:A49 99.78854.73NoNo044
31R:R:P96 S:S:L46 99.79211.64NoNo094
32R:R:A49 S:S:L46 99.78134.73NoNo044
33R:R:A49 S:S:A49 99.78131.79NoNo044
34R:R:A57 R:R:G58 60.67881.95NoNo048
35R:R:G58 R:R:P340 60.72934.06NoYes089
36R:R:N59 R:R:P340 62.65299.77YesYes099
37R:R:I55 R:R:N59 43.27894.25YesYes179
38R:R:G91 R:R:I55 49.30557.05NoYes077
39R:R:G91 R:R:V95 57.45883.68NoYes077
40R:R:A57 R:R:L53 65.48723.15NoNo045
41S:S:G91 S:S:V95 84.82523.68NoYes077
42S:S:G91 S:S:I55 76.69357.05NoYes077
43S:S:I55 S:S:N59 70.84714.25YesYes279
44S:S:N59 S:S:P340 92.13389.77YesYes099
45S:S:G58 S:S:P340 61.42024.06NoYes089
46S:S:A57 S:S:G58 61.25681.95NoNo048
47S:S:A57 S:S:L53 65.63383.15NoNo045
48R:R:L53 S:S:L53 65.556915.22NoNo055
49R:R:D87 R:R:N59 29.46536.73YesYes199
50R:R:D87 R:R:S336 11.65938.83YesYes199
51R:R:P340 R:R:V62 61.89353.53YesYes099
52R:R:F349 R:R:V62 11.29166.55YesYes989
53R:R:I66 R:R:V62 26.25263.07YesYes079
54R:R:V62 R:R:Y343 22.8863.79YesNo999
55R:R:I66 R:R:I80 22.49672.94YesNo077
56R:R:I80 R:R:Y343 23.010916.92NoNo079
57R:R:F349 R:R:L72 11.80942.44YesNo088
58R:R:I135 R:R:I80 43.89882.94NoNo097
59R:R:F79 R:R:I135 41.92845.02YesNo089
60R:R:F79 R:R:M153 48.73362.49YesNo086
61R:R:D138 R:R:M153 43.14436.93NoNo096
62R:R:D138 R:R:T76 41.7412.89NoYes098
63R:R:R139 R:R:T76 34.65826.47NoYes098
64R:R:D87 R:R:L83 24.32065.43YesYes199
65R:R:L83 R:R:T131 29.57475.9YesNo098
66R:R:T131 R:R:V165 18.97033.17NoNo086
67R:R:I161 R:R:V165 16.86771.54NoNo066
68R:R:I161 R:R:V134 14.25091.54NoNo065
69R:R:T118 R:R:W117 57.47573.64NoYes066
70R:R:I177 R:R:T118 61.70013.04YesNo066
71R:R:I177 R:R:S119 13.558812.39YesNo366
72R:R:F174 R:R:S119 12.632510.57YesNo356
73R:R:F174 R:R:L123 22.57962.44YesNo055
74R:R:L123 R:R:S169 20.38093NoNo058
75R:R:A127 R:R:S169 18.30473.42NoNo078
76R:R:A127 R:R:W166 18.2596.48NoYes079
77R:R:I177 R:R:M178 15.75994.37YesYes364
78R:R:F174 R:R:M178 12.98094.98YesYes354
79R:R:V95 R:R:Y333 31.40452.52YesYes577
80R:R:N329 R:R:Y333 39.1776.98YesYes567
81R:R:N329 R:R:W303 28.98715.65YesYes568
82R:R:F299 R:R:W303 31.46943.01YesYes098
83R:R:F299 R:R:S128 12.47033.96YesNo099
84R:R:V94 R:R:W117 28.42723.68NoYes076
85R:R:V94 R:R:Y333 17.01195.05NoYes577
86R:R:D121 R:R:V94 11.97654.38NoNo577
87R:R:D121 R:R:N329 12.03414.04NoYes576
88R:R:F299 R:R:L132 13.53247.31YesYes098
89R:R:R104 S:S:Q38 22.209518.69NoNo043
90R:R:L108 S:S:Q39 10.346.65YesNo042
91R:R:I177 R:R:W182 41.21354.7YesYes365
92R:R:F307 R:R:W303 10.31128.02YesYes578
93R:R:F306 R:R:N329 21.644815.71YesYes576
94R:R:S169 R:R:T126 15.09914.8NoNo086
95R:R:E285 R:R:R139 31.85035.82YesNo079
96R:R:E285 R:R:I143 24.71341.37YesNo079
97R:R:E233 R:R:I143 23.27895.47NoNo069
98R:R:E233 R:R:T144 20.40257.06NoNo067
99R:R:T144 R:R:Y140 14.620916.23NoYes078
100R:R:L141 R:R:Y140 10.25952.34NoYes058
101R:R:W182 R:R:Y207 19.5535.79YesYes357
102R:R:W182 R:R:Y193 11.85038.68YesYes353
103R:R:N204 R:R:Y207 10.55274.65NoYes057
104R:R:F216 R:R:F307 16.132421.43YesYes077
105R:R:F306 R:R:F328 21.02974.29YesYes075
106S:S:E41 S:S:R104 22.20718.14NoNo054
107S:S:E41 S:S:Q38 22.202317.84NoNo053
108S:S:D87 S:S:N59 29.91476.73YesYes299
109S:S:P340 S:S:V62 1003.53YesYes099
110S:S:F349 S:S:V62 12.35615.24YesYes1189
111S:S:I66 S:S:V62 44.833.07YesYes079
112S:S:V62 S:S:Y343 40.96123.79YesNo1199
113S:S:I66 S:S:I80 40.76292.94YesNo077
114S:S:I80 S:S:Y343 40.987616.92NoNo079
115S:S:F349 S:S:L72 12.77062.44YesNo088
116S:S:I135 S:S:I80 79.96282.94NoNo097
117S:S:F79 S:S:I135 76.44965.02YesNo089
118S:S:F79 S:S:M153 65.78762.49YesNo086
119S:S:D138 S:S:M153 58.63156.93NoNo096
120S:S:D138 S:S:T76 56.83652.89NoYes098
121S:S:R139 S:S:T76 47.79296.47NoYes098
122S:S:D87 S:S:L83 19.0584.07YesYes299
123S:S:L83 S:S:T131 16.2855.9YesNo098
124S:S:D87 S:S:S128 11.96562.94YesNo299
125S:S:V95 S:S:Y333 41.76862.52YesYes677
126S:S:N329 S:S:Y333 43.5186.98YesYes667
127S:S:N329 S:S:W303 35.55456.78YesYes668
128S:S:F299 S:S:W303 35.70114.01YesYes098
129S:S:F299 S:S:S128 14.87443.96YesNo099
130S:S:V94 S:S:W117 46.99633.68NoYes076
131S:S:V94 S:S:Y333 31.20035.05NoYes677
132S:S:D121 S:S:V94 16.18174.38NoNo677
133S:S:D121 S:S:N329 16.14564.04NoYes676
134S:S:F299 S:S:L132 13.93256.09YesYes098
135S:S:C114 S:S:W107 12.31415.22NoYes897
136S:S:C114 S:S:S111 10.18745.16NoNo094
137S:S:T118 S:S:W117 97.34473.64NoYes066
138S:S:I177 S:S:T118 99.41613.04YesNo066
139S:S:I177 S:S:M178 25.9394.37YesYes464
140S:S:I177 S:S:W182 48.78774.7YesYes465
141S:S:I177 S:S:S119 22.887210.84YesNo466
142S:S:F174 S:S:S119 21.378110.57YesNo456
143S:S:F174 S:S:M178 21.41184.98YesYes454
144S:S:F174 S:S:L123 36.70672.44YesNo055
145S:S:L123 S:S:S169 27.56223NoNo058
146S:S:F307 S:S:W303 10.54918.02YesYes678
147S:S:F306 S:S:N329 23.389415.71YesYes676
148S:S:S169 S:S:T126 24.50924.8NoNo086
149S:S:S215 S:S:T126 12.27329.59NoNo066
150S:S:L132 S:S:M296 10.61522.83YesYes288
151S:S:E285 S:S:R139 44.2045.82YesNo079
152S:S:E285 S:S:I143 31.45381.37YesNo079
153S:S:E233 S:S:I143 29.62275.47NoNo069
154S:S:E233 S:S:T144 25.95347.06NoNo067
155S:S:T144 S:S:Y140 18.585816.23NoYes078
156S:S:L141 S:S:Y140 13.0352.34NoYes058
157S:S:L141 S:S:L152 11.17991.38NoNo055
158S:S:W182 S:S:Y207 23.10345.79YesYes457
159S:S:W182 S:S:Y193 13.98058.68YesYes453
160S:S:N204 S:S:Y207 12.44624.65NoYes057
161S:S:F216 S:S:F307 16.987921.43YesYes077
162S:S:F306 S:S:F328 21.18114.29YesYes075
163R:R:L132 R:R:L83 13.6852.77YesYes189
164R:R:V165 R:R:W166 13.48792.45NoYes069
165S:S:L132 S:S:L83 12.47992.77YesYes289
166R:R:F79 R:R:V134 13.33776.55YesNo085
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 4GPO_poly
Class A
SubFamily Amine
Type Adrenergic
SubType Beta1
Species Meleagris gallopavo
Ligand -
Other Ligand(s) -
Protein Partners -
PDB Resolution 3.5
Date 2013-02-27
D.O.I. 10.1038/nsmb.2504
Net Summary
Imin 2.43
Number of Linked Nodes 514
Number of Links 602
Number of Hubs 86
Number of Links mediated by Hubs 300
Number of Communities 12
Number of Nodes involved in Communities 94
Number of Links involved in Communities 128
Path Summary
Number Of Nodes in MetaPath 167
Number Of Links MetaPath 166
Number of Shortest Paths 340691
Length Of Smallest Path 3
Average Path Length 18.2072
Length of Longest Path 46
Minimum Path Strength 1.235
Average Path Strength 5.19217
Maximum Path Strength 18.265
Minimum Path Correlation 0.7
Average Path Correlation 0.966391
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 57.5915
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.7058
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtP07700
Sequence
>4GPO_poly_Chain_R
LSQQWEAGM SLLMALVVL LIVAGNVLV IAAIGSTQR LQTLTNLFI 
TSLACADLV VGLLVVPFG ATLVVRGTW LWGSFLCEL WTSLDVLCV 
TASIETLCV IAIDRYLAI TSPFRYQSL MTRARAKVI ICTVWAISA 
LVSFLPIMM HWWRDEDPQ ALKCYQDPG CCDFVTNRA YAIASSIIS 
FYIPLLIMI FVALRVYRE AKEQVMLMR EHKALKTLG IIMGVFTLC 
WLPFFLVNI VNVFNRDLV PDWLFVAFN WLGYANSAM NPIIYCRSP 
DFRKAFKRL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
2VT4AAmineAdrenergicβ1Meleagris gallopavoCyanopindolol--2.72008-06-2410.1038/nature07101
2Y00AAmineAdrenergicβ1Meleagris gallopavoDobutamine--2.52011-01-1210.1038/nature09746
2Y01AAmineAdrenergicβ1Meleagris gallopavoDobutamine--2.62011-03-3010.1038/nature09746
2Y02AAmineAdrenergicβ1Meleagris gallopavoCarmoterol--2.62011-01-1210.1038/nature09746
2Y03AAmineAdrenergicβ1Meleagris gallopavoIsoprenaline--2.852011-01-1210.1038/nature09746
2Y04AAmineAdrenergicβ1Meleagris gallopavoSalbutamol--3.052011-01-1210.1038/nature09746
2YCWAAmineAdrenergicβ1Meleagris gallopavo(S)-Carazolol--32011-06-0110.1073/pnas.1100185108
2YCXAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol--3.252011-06-0110.1073/pnas.1100185108
2YCYAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol--3.152011-06-0810.1073/pnas.1100185108
2YCZAAmineAdrenergicβ1Meleagris gallopavoIodocyanopindolol--3.652011-06-0110.1073/pnas.1100185108
3ZPQAAmineAdrenergicβ1Meleagris gallopavo4-(piperazin-1- yl)-1H-indoleNa-2.82013-04-0310.1021/jm400140q
3ZPRAAmineAdrenergicβ1Meleagris gallopavo4-methyl-2-(piperazin-1-yl)Na-2.72013-04-0310.1021/jm400140q
4AMIAAmineAdrenergicβ1Meleagris gallopavoBucindolol--3.22012-05-2310.1016/j.str.2012.03.014
4AMJAAmineAdrenergicβ1Meleagris gallopavo(S)-Carvedilol--2.32012-05-2310.1016/j.str.2012.03.014
4BVNAAmineAdrenergicβ1Meleagris gallopavoCyanopindololNa-2.12014-04-0210.1371/journal.pone.0092727
4GPOAAmineAdrenergicβ1Meleagris gallopavo---3.52013-02-2710.1038/nsmb.2504
5A8EAAmineAdrenergicβ1Meleagris gallopavo7-MethylcyanopindololNa-2.42015-09-3010.1124/mol.115.101030
5F8UAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol--3.352015-12-2310.1038/nsmb.3130
6H7JAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline--2.82018-10-1710.1126/science.aau5595
6H7LAAmineAdrenergicβ1Meleagris gallopavoDobutamine--2.72018-10-1710.1126/science.aau5595
6H7MAAmineAdrenergicβ1Meleagris gallopavoSalbutamol--2.762018-10-1710.1126/science.aau5595
6H7NAAmineAdrenergicβ1Meleagris gallopavo(S)-Xamoterol--2.52018-10-1710.1101/436212
6H7OAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol--2.82018-10-1710.1126/science.aau5595
6IBLAAmineAdrenergicβ1Meleagris gallopavoArformoterol--2.72019-01-0910.1038/s41586-020-2419-1
6TKOAAmineAdrenergicβ1Meleagris gallopavoArformoterol-Arrestin23.32020-06-1710.1038/s41586-020-2419-1
7BTSAAmineAdrenergicβ1Homo sapiensL-Epinephrine--3.132020-12-0210.1038/s41422-020-00424-2
7BU6AAmineAdrenergicβ1Homo sapiensL-Norepinephrine--2.72020-12-0210.1038/s41422-020-00424-2
7BU7AAmineAdrenergicβ1Homo sapiensBI167107--2.62020-12-0210.1038/s41422-020-00424-2
7BVQAAmineAdrenergicβ1Homo sapiens(S)-Carazolol--2.52020-12-0210.1038/s41422-020-00424-2
7JJOAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-Gs/&β;1/&γ;22.62020-09-0210.1016/j.molcel.2020.08.001
7S0FAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-Gi1/&β;1/&γ;22.962021-11-1710.1038/s41594-021-00679-2
7S0GAAmineAdrenergicβ1Meleagris gallopavoIsoprenaline-chim(Gi1-CtGs)/&β;1/&γ;23.862021-11-1710.1038/s41594-021-00679-2
8DCRAAmineAdrenergicβ1Meleagris gallopavoDobutamine-Gs/&β;1/&γ;22.62022-07-2710.1038/s41467-022-31823-1
8DCSAAmineAdrenergicβ1Meleagris gallopavoCyanopindolol-Gs/&β;1/&γ;22.52022-07-2710.1038/s41467-022-31823-1
4GPO (Dimer)AAmineAdrenergicβ1Meleagris gallopavo---3.52013-02-2710.1038/nsmb.2504




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 4GPO_poly.zip



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